-- dump date 20140619_231310 -- class Genbank::misc_feature -- table misc_feature_note -- id note 765952000001 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 765952000002 Isochorismatase family; Region: Isochorismatase; pfam00857 765952000003 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 765952000004 catalytic triad [active] 765952000005 dimer interface [polypeptide binding]; other site 765952000006 conserved cis-peptide bond; other site 765952000007 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 765952000008 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 765952000009 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765952000010 substrate binding pocket [chemical binding]; other site 765952000011 chain length determination region; other site 765952000012 substrate-Mg2+ binding site; other site 765952000013 catalytic residues [active] 765952000014 aspartate-rich region 1; other site 765952000015 active site lid residues [active] 765952000016 aspartate-rich region 2; other site 765952000017 recombinase A; Provisional; Region: recA; PRK09354 765952000018 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 765952000019 hexamer interface [polypeptide binding]; other site 765952000020 Walker A motif; other site 765952000021 ATP binding site [chemical binding]; other site 765952000022 Walker B motif; other site 765952000023 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 765952000024 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 765952000025 active site 765952000026 dimerization interface [polypeptide binding]; other site 765952000027 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 765952000028 ATP cone domain; Region: ATP-cone; pfam03477 765952000029 ATP cone domain; Region: ATP-cone; pfam03477 765952000030 Class I ribonucleotide reductase; Region: RNR_I; cd01679 765952000031 active site 765952000032 dimer interface [polypeptide binding]; other site 765952000033 catalytic residues [active] 765952000034 effector binding site; other site 765952000035 R2 peptide binding site; other site 765952000036 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 765952000037 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 765952000038 dimer interface [polypeptide binding]; other site 765952000039 putative radical transfer pathway; other site 765952000040 diiron center [ion binding]; other site 765952000041 tyrosyl radical; other site 765952000042 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 765952000043 active site 765952000044 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 765952000045 homodimer interface [polypeptide binding]; other site 765952000046 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 765952000047 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 765952000048 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 765952000049 putative trimer interface [polypeptide binding]; other site 765952000050 putative active site [active] 765952000051 putative substrate binding site [chemical binding]; other site 765952000052 putative CoA binding site [chemical binding]; other site 765952000053 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 765952000054 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 765952000055 inhibitor-cofactor binding pocket; inhibition site 765952000056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000057 catalytic residue [active] 765952000058 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 765952000059 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 765952000060 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 765952000061 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 765952000062 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 765952000063 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 765952000064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952000065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952000066 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 765952000067 Methyltransferase domain; Region: Methyltransf_24; pfam13578 765952000068 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952000069 active site 765952000070 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 765952000071 active site 765952000072 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952000073 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952000074 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 765952000075 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 765952000076 active site 765952000077 Zn binding site [ion binding]; other site 765952000078 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 765952000079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952000080 FeS/SAM binding site; other site 765952000081 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 765952000082 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 765952000083 Phosphagen (guanidino) kinases; Region: phosphagen_kinases; cl02823 765952000084 ADP binding site [chemical binding]; other site 765952000085 phosphagen binding site; other site 765952000086 substrate specificity loop; other site 765952000087 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 765952000088 UvrB/uvrC motif; Region: UVR; pfam02151 765952000089 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 765952000090 ribosome recycling factor; Reviewed; Region: frr; PRK00083 765952000091 hinge region; other site 765952000092 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 765952000093 putative nucleotide binding site [chemical binding]; other site 765952000094 uridine monophosphate binding site [chemical binding]; other site 765952000095 homohexameric interface [polypeptide binding]; other site 765952000096 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 765952000097 ligand binding site [chemical binding]; other site 765952000098 active site 765952000099 UGI interface [polypeptide binding]; other site 765952000100 catalytic site [active] 765952000101 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 765952000102 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 765952000103 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 765952000104 transmembrane helices; other site 765952000105 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 765952000106 Protein of unknown function DUF58; Region: DUF58; pfam01882 765952000107 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 765952000108 metal ion-dependent adhesion site (MIDAS); other site 765952000109 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 765952000110 U-box domain; Region: U-box; cl17544 765952000111 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 765952000112 Iron-sulfur protein interface; other site 765952000113 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 765952000114 proximal heme binding site [chemical binding]; other site 765952000115 Iron-sulfur protein interface; other site 765952000116 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 765952000117 L-aspartate oxidase; Provisional; Region: PRK06175 765952000118 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 765952000119 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 765952000120 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 765952000121 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 765952000122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952000123 Coenzyme A binding pocket [chemical binding]; other site 765952000124 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 765952000125 UbiA prenyltransferase family; Region: UbiA; pfam01040 765952000126 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 765952000127 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 765952000128 Subunit I/III interface [polypeptide binding]; other site 765952000129 Subunit III/IV interface [polypeptide binding]; other site 765952000130 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 765952000131 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 765952000132 D-pathway; other site 765952000133 Putative ubiquinol binding site [chemical binding]; other site 765952000134 Low-spin heme (heme b) binding site [chemical binding]; other site 765952000135 Putative water exit pathway; other site 765952000136 Binuclear center (heme o3/CuB) [ion binding]; other site 765952000137 K-pathway; other site 765952000138 Putative proton exit pathway; other site 765952000139 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 765952000140 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 765952000141 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 765952000142 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 765952000143 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 765952000144 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 765952000145 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 765952000146 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 765952000147 excinuclease ABC subunit B; Provisional; Region: PRK05298 765952000148 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 765952000149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000150 ATP-binding site [chemical binding]; other site 765952000151 ATP binding site [chemical binding]; other site 765952000152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000153 nucleotide binding region [chemical binding]; other site 765952000154 ATP-binding site [chemical binding]; other site 765952000155 Ultra-violet resistance protein B; Region: UvrB; pfam12344 765952000156 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 765952000157 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 765952000158 active site 765952000159 HIGH motif; other site 765952000160 dimer interface [polypeptide binding]; other site 765952000161 KMSKS motif; other site 765952000162 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765952000163 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952000164 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765952000165 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952000166 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952000167 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000168 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000169 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000170 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000171 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000172 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952000173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952000174 dimer interface [polypeptide binding]; other site 765952000175 putative CheW interface [polypeptide binding]; other site 765952000176 TspO/MBR family; Region: TspO_MBR; pfam03073 765952000177 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 765952000178 active site 765952000179 conformational flexibility of ligand binding pocket; other site 765952000180 ADP-ribosylating toxin turn-turn motif; other site 765952000181 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 765952000182 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 765952000183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 765952000184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952000185 active site 765952000186 phosphorylation site [posttranslational modification] 765952000187 intermolecular recognition site; other site 765952000188 dimerization interface [polypeptide binding]; other site 765952000189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 765952000190 DNA binding site [nucleotide binding] 765952000191 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 765952000192 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 765952000193 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 765952000194 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952000195 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 765952000196 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 765952000197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000198 putative substrate translocation pore; other site 765952000199 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952000200 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952000201 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 765952000202 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952000203 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952000204 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952000205 U-box domain; Region: U-box; cl17544 765952000206 AAA domain; Region: AAA_30; pfam13604 765952000207 Family description; Region: UvrD_C_2; pfam13538 765952000208 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 765952000209 Part of AAA domain; Region: AAA_19; pfam13245 765952000210 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 765952000211 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 765952000212 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 765952000213 BON domain; Region: BON; pfam04972 765952000214 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 765952000215 dimerization interface [polypeptide binding]; other site 765952000216 metal binding site [ion binding]; metal-binding site 765952000217 CsbD-like; Region: CsbD; cl17424 765952000218 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 765952000219 Domain of unknown function DUF20; Region: UPF0118; pfam01594 765952000220 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 765952000221 YtxH-like protein; Region: YtxH; pfam12732 765952000222 YtxH-like protein; Region: YtxH; pfam12732 765952000223 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 765952000224 Uncharacterized conserved protein [Function unknown]; Region: COG3287 765952000225 FIST N domain; Region: FIST; pfam08495 765952000226 FIST C domain; Region: FIST_C; pfam10442 765952000227 FIST N domain; Region: FIST; pfam08495 765952000228 Uncharacterized conserved protein [Function unknown]; Region: COG3287 765952000229 FIST C domain; Region: FIST_C; pfam10442 765952000230 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 765952000231 competence damage-inducible protein A; Provisional; Region: PRK00549 765952000232 putative MPT binding site; other site 765952000233 Competence-damaged protein; Region: CinA; pfam02464 765952000234 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 765952000235 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 765952000236 ligand binding site [chemical binding]; other site 765952000237 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 765952000238 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 765952000239 glutamate racemase; Provisional; Region: PRK00865 765952000240 RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570 765952000241 catalytic residue [active] 765952000242 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 765952000243 isocitrate dehydrogenase; Validated; Region: PRK09222 765952000244 KpsF/GutQ family protein; Region: kpsF; TIGR00393 765952000245 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 765952000246 putative active site [active] 765952000247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 765952000248 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 765952000249 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 765952000250 ATP binding site [chemical binding]; other site 765952000251 putative Mg++ binding site [ion binding]; other site 765952000252 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 765952000253 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000254 nucleotide binding region [chemical binding]; other site 765952000255 ATP-binding site [chemical binding]; other site 765952000256 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 765952000257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765952000258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000259 homodimer interface [polypeptide binding]; other site 765952000260 catalytic residue [active] 765952000261 rod shape-determining protein MreC; Region: MreC; pfam04085 765952000262 rod shape-determining protein MreC; Region: MreC; pfam04085 765952000263 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 765952000264 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 765952000265 active site 765952000266 NTP binding site [chemical binding]; other site 765952000267 metal binding triad [ion binding]; metal-binding site 765952000268 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 765952000269 16S rRNA methyltransferase B; Provisional; Region: PRK14902 765952000270 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 765952000271 putative RNA binding site [nucleotide binding]; other site 765952000272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000273 S-adenosylmethionine binding site [chemical binding]; other site 765952000274 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; cl01262 765952000275 hypothetical protein; Provisional; Region: PRK05409 765952000276 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 765952000277 peptide chain release factor 2; Validated; Region: prfB; PRK00578 765952000278 This domain is found in peptide chain release factors; Region: PCRF; smart00937 765952000279 RF-1 domain; Region: RF-1; pfam00472 765952000280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952000281 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765952000282 Coenzyme A binding pocket [chemical binding]; other site 765952000283 SprT-like family; Region: SprT-like; pfam10263 765952000284 hypothetical protein; Validated; Region: PRK00110 765952000285 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 765952000286 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 765952000287 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 765952000288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952000289 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 765952000290 putative NAD(P) binding site [chemical binding]; other site 765952000291 active site 765952000292 putative substrate binding site [chemical binding]; other site 765952000293 YGGT family; Region: YGGT; pfam02325 765952000294 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 765952000295 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 765952000296 FMN binding site [chemical binding]; other site 765952000297 active site 765952000298 catalytic residues [active] 765952000299 substrate binding site [chemical binding]; other site 765952000300 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 765952000301 type III secretion system protein; Validated; Region: PRK06328 765952000302 Flagellar assembly protein FliH; Region: FliH; pfam02108 765952000303 type III secretion system protein; Reviewed; Region: PRK09617 765952000304 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 765952000305 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 765952000306 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 765952000307 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 765952000308 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 765952000309 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 765952000310 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 765952000311 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 765952000312 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 765952000313 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 765952000314 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765952000315 Clp protease; Region: CLP_protease; pfam00574 765952000316 oligomer interface [polypeptide binding]; other site 765952000317 active site residues [active] 765952000318 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 765952000319 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 765952000320 hinge; other site 765952000321 active site 765952000322 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 765952000323 homotrimer interaction site [polypeptide binding]; other site 765952000324 zinc binding site [ion binding]; other site 765952000325 CDP-binding sites; other site 765952000326 FAD binding domain; Region: FAD_binding_1; pfam00667 765952000327 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 765952000328 FAD binding pocket [chemical binding]; other site 765952000329 FAD binding motif [chemical binding]; other site 765952000330 catalytic residues [active] 765952000331 NAD binding pocket [chemical binding]; other site 765952000332 phosphate binding motif [ion binding]; other site 765952000333 beta-alpha-beta structure motif; other site 765952000334 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 765952000335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952000336 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952000337 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765952000338 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765952000339 Walker A/P-loop; other site 765952000340 ATP binding site [chemical binding]; other site 765952000341 Q-loop/lid; other site 765952000342 ABC transporter signature motif; other site 765952000343 Walker B; other site 765952000344 D-loop; other site 765952000345 H-loop/switch region; other site 765952000346 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 765952000347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765952000348 Walker A/P-loop; other site 765952000349 ATP binding site [chemical binding]; other site 765952000350 Q-loop/lid; other site 765952000351 ABC transporter signature motif; other site 765952000352 Walker B; other site 765952000353 D-loop; other site 765952000354 H-loop/switch region; other site 765952000355 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 765952000356 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 765952000357 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 765952000358 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 765952000359 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952000360 aconitate hydratase; Validated; Region: PRK09277 765952000361 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 765952000362 substrate binding site [chemical binding]; other site 765952000363 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 765952000364 ligand binding site [chemical binding]; other site 765952000365 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 765952000366 substrate binding site [chemical binding]; other site 765952000367 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 765952000368 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 765952000369 active site 765952000370 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952000371 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952000372 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 765952000373 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952000374 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 765952000375 active site 765952000376 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 765952000377 RNAase interaction site [polypeptide binding]; other site 765952000378 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 765952000379 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 765952000380 DDE superfamily endonuclease; Region: DDE_3; pfam13358 765952000381 Winged helix-turn helix; Region: HTH_33; pfam13592 765952000382 Homeodomain-like domain; Region: HTH_23; pfam13384 765952000383 Winged helix-turn helix; Region: HTH_29; pfam13551 765952000384 Winged helix-turn helix; Region: HTH_33; pfam13592 765952000385 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952000386 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 765952000387 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 765952000388 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952000389 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952000390 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952000391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952000392 active site 765952000393 SWIB/MDM2 domain; Region: SWIB; pfam02201 765952000394 phosphodiesterase YaeI; Provisional; Region: PRK11340 765952000395 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 765952000396 putative active site [active] 765952000397 putative metal binding site [ion binding]; other site 765952000398 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 765952000399 substrate binding site; other site 765952000400 dimer interface; other site 765952000401 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 765952000402 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 765952000403 dimerization interface 3.5A [polypeptide binding]; other site 765952000404 active site 765952000405 Thymidylate synthase complementing protein; Region: Thy1; cl03630 765952000406 Thymidylate synthase complementing protein; Region: Thy1; cl03630 765952000407 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 765952000408 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765952000409 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765952000410 ring oligomerisation interface [polypeptide binding]; other site 765952000411 ATP/Mg binding site [chemical binding]; other site 765952000412 stacking interactions; other site 765952000413 hinge regions; other site 765952000414 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 765952000415 oligomerisation interface [polypeptide binding]; other site 765952000416 mobile loop; other site 765952000417 roof hairpin; other site 765952000418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952000419 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 765952000420 nucleophilic elbow; other site 765952000421 catalytic triad; other site 765952000422 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765952000423 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952000424 ABC-ATPase subunit interface; other site 765952000425 dimer interface [polypeptide binding]; other site 765952000426 putative PBP binding regions; other site 765952000427 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765952000428 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952000429 ABC-ATPase subunit interface; other site 765952000430 dimer interface [polypeptide binding]; other site 765952000431 putative PBP binding regions; other site 765952000432 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 765952000433 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 765952000434 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 765952000435 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 765952000436 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765952000437 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765952000438 intersubunit interface [polypeptide binding]; other site 765952000439 Protein of unknown function (DUF971); Region: DUF971; pfam06155 765952000440 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 765952000441 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 765952000442 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952000443 S-adenosylmethionine synthetase; Validated; Region: PRK05250 765952000444 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 765952000445 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 765952000446 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 765952000447 Domain of unknown function (DUF814); Region: DUF814; pfam05670 765952000448 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 765952000449 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 765952000450 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 765952000451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952000452 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 765952000453 Methyltransferase domain; Region: Methyltransf_23; pfam13489 765952000454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000455 S-adenosylmethionine binding site [chemical binding]; other site 765952000456 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 765952000457 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765952000458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000459 homodimer interface [polypeptide binding]; other site 765952000460 catalytic residue [active] 765952000461 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 765952000462 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 765952000463 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 765952000464 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 765952000465 dihydrodipicolinate synthase; Region: dapA; TIGR00674 765952000466 dimer interface [polypeptide binding]; other site 765952000467 active site 765952000468 catalytic residue [active] 765952000469 dihydrodipicolinate reductase; Provisional; Region: PRK00048 765952000470 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 765952000471 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 765952000472 polysaccharide export protein Wza; Provisional; Region: PRK15078 765952000473 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 765952000474 Ras GTPase Activating Domain; Region: RasGAP; cd04519 765952000475 RAS interface [polypeptide binding]; other site 765952000476 Chlamydial GcvH-like protein upstream region protein; Region: near_not_gcvH; TIGR03076 765952000477 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 765952000478 putative ligand binding site [chemical binding]; other site 765952000479 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 765952000480 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 765952000481 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 765952000482 lipoyl attachment site [posttranslational modification]; other site 765952000483 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 765952000484 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 765952000485 tetramer interface [polypeptide binding]; other site 765952000486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952000487 catalytic residue [active] 765952000488 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 765952000489 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952000490 catalytic residue [active] 765952000491 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 765952000492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000493 ATP binding site [chemical binding]; other site 765952000494 putative Mg++ binding site [ion binding]; other site 765952000495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000496 nucleotide binding region [chemical binding]; other site 765952000497 ATP-binding site [chemical binding]; other site 765952000498 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 765952000499 GTP cyclohydrolase I; Provisional; Region: PLN03044 765952000500 active site 765952000501 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 765952000502 active site 765952000503 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025 765952000504 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 765952000505 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952000506 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952000507 Ubiquitin carboxyl-terminal hydrolase; Region: UCH; pfam00443 765952000508 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 765952000509 active site 765952000510 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000511 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000512 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000513 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000514 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000515 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000516 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 765952000517 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765952000518 E3 interaction surface; other site 765952000519 lipoyl attachment site [posttranslational modification]; other site 765952000520 e3 binding domain; Region: E3_binding; pfam02817 765952000521 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 765952000522 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 765952000523 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 765952000524 alpha subunit interface [polypeptide binding]; other site 765952000525 TPP binding site [chemical binding]; other site 765952000526 heterodimer interface [polypeptide binding]; other site 765952000527 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952000528 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 765952000529 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 765952000530 tetramer interface [polypeptide binding]; other site 765952000531 TPP-binding site [chemical binding]; other site 765952000532 heterodimer interface [polypeptide binding]; other site 765952000533 phosphorylation loop region [posttranslational modification] 765952000534 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 765952000535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000536 putative substrate translocation pore; other site 765952000537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000538 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 765952000539 active site 765952000540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 765952000541 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 765952000542 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952000543 substrate binding site [chemical binding]; other site 765952000544 oxyanion hole (OAH) forming residues; other site 765952000545 trimer interface [polypeptide binding]; other site 765952000546 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 765952000547 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952000548 putative catalytic site [active] 765952000549 putative metal binding site [ion binding]; other site 765952000550 putative phosphate binding site [ion binding]; other site 765952000551 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952000552 putative catalytic site [active] 765952000553 putative metal binding site [ion binding]; other site 765952000554 putative phosphate binding site [ion binding]; other site 765952000555 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 765952000556 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 765952000557 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 765952000558 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 765952000559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 765952000560 active site 765952000561 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 765952000562 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 765952000563 aminopeptidase N; Provisional; Region: pepN; PRK14015 765952000564 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 765952000565 active site 765952000566 Zn binding site [ion binding]; other site 765952000567 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 765952000568 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 765952000569 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 765952000570 hypothetical protein; Reviewed; Region: PRK09588 765952000571 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952000572 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 765952000573 putative NAD(P) binding site [chemical binding]; other site 765952000574 putative substrate binding site [chemical binding]; other site 765952000575 catalytic Zn binding site [ion binding]; other site 765952000576 structural Zn binding site [ion binding]; other site 765952000577 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000578 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000579 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000580 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952000582 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765952000583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765952000584 active site residue [active] 765952000585 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 765952000586 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 765952000587 active site 765952000588 DNA binding site [nucleotide binding] 765952000589 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 765952000590 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 765952000591 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 765952000592 Catalytic site [active] 765952000593 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 765952000594 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 765952000595 hypothetical protein; Reviewed; Region: PRK09588 765952000596 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 765952000597 Predicted ATPase involved in replication control, Cdc46/Mcm family [DNA replication, recombination, and repair]; Region: MCM2; COG1241 765952000598 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 765952000599 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 765952000600 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 765952000601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000602 ATP binding site [chemical binding]; other site 765952000603 putative Mg++ binding site [ion binding]; other site 765952000604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000605 nucleotide binding region [chemical binding]; other site 765952000606 ATP-binding site [chemical binding]; other site 765952000607 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 765952000608 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 765952000609 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 765952000610 motif 1; other site 765952000611 active site 765952000612 motif 2; other site 765952000613 motif 3; other site 765952000614 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 765952000615 DHHA1 domain; Region: DHHA1; pfam02272 765952000616 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 765952000617 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 765952000618 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952000619 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952000620 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952000621 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952000622 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 765952000623 Glycoprotease family; Region: Peptidase_M22; pfam00814 765952000624 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 765952000625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765952000626 Zn2+ binding site [ion binding]; other site 765952000627 Mg2+ binding site [ion binding]; other site 765952000628 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 765952000629 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 765952000630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952000631 Walker A motif; other site 765952000632 ATP binding site [chemical binding]; other site 765952000633 Walker B motif; other site 765952000634 arginine finger; other site 765952000635 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 765952000636 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952000637 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 765952000638 active site 765952000639 nucleotide binding site [chemical binding]; other site 765952000640 HIGH motif; other site 765952000641 KMSKS motif; other site 765952000642 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 765952000643 Rhomboid family; Region: Rhomboid; pfam01694 765952000644 ribonuclease Z; Region: RNase_Z; TIGR02651 765952000645 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 765952000646 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952000647 active site 765952000648 DNA binding site [nucleotide binding] 765952000649 Int/Topo IB signature motif; other site 765952000650 F-box-like; Region: F-box-like; cl02535 765952000651 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000652 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952000653 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 765952000654 active site 765952000655 nucleophile elbow; other site 765952000656 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765952000657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952000658 Walker A/P-loop; other site 765952000659 ATP binding site [chemical binding]; other site 765952000660 Q-loop/lid; other site 765952000661 ABC transporter signature motif; other site 765952000662 Walker B; other site 765952000663 D-loop; other site 765952000664 H-loop/switch region; other site 765952000665 ABC transporter; Region: ABC_tran_2; pfam12848 765952000666 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765952000667 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765952000668 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 765952000669 GTP cyclohydrolase I; Provisional; Region: PLN03044 765952000670 active site 765952000671 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 765952000672 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 765952000673 Predicted membrane protein [Function unknown]; Region: COG1289 765952000674 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 765952000675 flavoprotein, HI0933 family; Region: TIGR00275 765952000676 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 765952000677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000678 S-adenosylmethionine binding site [chemical binding]; other site 765952000679 Pleckstrin homology-like domain; Region: PH-like; cl17171 765952000680 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 765952000681 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 765952000682 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 765952000683 Protein export membrane protein; Region: SecD_SecF; pfam02355 765952000684 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000685 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000686 BTB/POZ domain; Region: BTB; cl02518 765952000687 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952000688 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952000689 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 765952000690 DHH family; Region: DHH; pfam01368 765952000691 DHHA1 domain; Region: DHHA1; pfam02272 765952000692 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 765952000693 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 765952000694 Autotransporter beta-domain; Region: Autotransporter; pfam03797 765952000695 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 765952000696 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 765952000697 putative transporter; Provisional; Region: PRK11660 765952000698 Sulfate transporter family; Region: Sulfate_transp; pfam00916 765952000699 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 765952000700 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952000701 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 765952000702 Walker A/P-loop; other site 765952000703 ATP binding site [chemical binding]; other site 765952000704 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 765952000705 ABC transporter signature motif; other site 765952000706 Walker B; other site 765952000707 D-loop; other site 765952000708 H-loop/switch region; other site 765952000709 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952000710 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952000711 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952000712 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 765952000713 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 765952000714 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 765952000715 active site 765952000716 zinc binding site [ion binding]; other site 765952000717 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 765952000718 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 765952000719 SpaB C-terminal domain; Region: SpaB_C; pfam14028 765952000720 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 765952000721 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 765952000722 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 765952000723 hexamer interface [polypeptide binding]; other site 765952000724 ligand binding site [chemical binding]; other site 765952000725 putative active site [active] 765952000726 NAD(P) binding site [chemical binding]; other site 765952000727 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 765952000728 nucleotide binding site [chemical binding]; other site 765952000729 putative NEF/HSP70 interaction site [polypeptide binding]; other site 765952000730 SBD interface [polypeptide binding]; other site 765952000731 DNA-K related protein; Region: DUF3731; pfam12531 765952000732 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 765952000733 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 765952000734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952000735 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765952000736 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 765952000737 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 765952000738 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 765952000739 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765952000740 HIGH motif; other site 765952000741 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 765952000742 active site 765952000743 KMSKS motif; other site 765952000744 C-terminal peptidase (prc); Region: prc; TIGR00225 765952000745 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 765952000746 protein binding site [polypeptide binding]; other site 765952000747 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 765952000748 Catalytic dyad [active] 765952000749 Helix-turn-helix domain; Region: HTH_17; cl17695 765952000750 Helix-turn-helix domain; Region: HTH_17; pfam12728 765952000751 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 765952000752 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 765952000753 Competence protein; Region: Competence; pfam03772 765952000754 HAMP domain; Region: HAMP; pfam00672 765952000755 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 765952000756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 765952000757 putative active site [active] 765952000758 heme pocket [chemical binding]; other site 765952000759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765952000760 dimer interface [polypeptide binding]; other site 765952000761 phosphorylation site [posttranslational modification] 765952000762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952000763 ATP binding site [chemical binding]; other site 765952000764 Mg2+ binding site [ion binding]; other site 765952000765 G-X-G motif; other site 765952000766 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 765952000767 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 765952000768 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 765952000769 active site 765952000770 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 765952000771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952000772 ATP binding site [chemical binding]; other site 765952000773 Mg2+ binding site [ion binding]; other site 765952000774 G-X-G motif; other site 765952000775 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 765952000776 ATP binding site [chemical binding]; other site 765952000777 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 765952000778 lysophospholipid transporter LplT; Provisional; Region: PRK11195 765952000779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952000780 putative substrate translocation pore; other site 765952000781 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 765952000782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765952000783 putative acyl-acceptor binding pocket; other site 765952000784 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 765952000785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000786 S-adenosylmethionine binding site [chemical binding]; other site 765952000787 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 765952000788 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 765952000789 transcript cleavage factor/unknown domain fusion protein; Validated; Region: PRK06330 765952000790 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 765952000791 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 765952000792 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 765952000793 active site 765952000794 dimerization interface [polypeptide binding]; other site 765952000795 YacP-like NYN domain; Region: NYN_YacP; cl01491 765952000796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000797 NAD(P) binding site [chemical binding]; other site 765952000798 active site 765952000799 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 765952000800 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 765952000801 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 765952000802 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 765952000803 putative acyl-acceptor binding pocket; other site 765952000804 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 765952000805 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 765952000806 homodimer interface [polypeptide binding]; other site 765952000807 oligonucleotide binding site [chemical binding]; other site 765952000808 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 765952000809 putative phosphate acyltransferase; Provisional; Region: PRK05331 765952000810 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 765952000811 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 765952000812 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 765952000813 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 765952000814 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 765952000815 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 765952000816 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 765952000817 active site 765952000818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952000819 Coenzyme A binding pocket [chemical binding]; other site 765952000820 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 765952000821 putative acyl-acceptor binding pocket; other site 765952000822 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 765952000823 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 765952000824 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 765952000825 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 765952000826 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 765952000827 Ligand binding site; other site 765952000828 Putative Catalytic site; other site 765952000829 DXD motif; other site 765952000830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952000831 poly(A) polymerase; Region: pcnB; TIGR01942 765952000832 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 765952000833 active site 765952000834 NTP binding site [chemical binding]; other site 765952000835 metal binding triad [ion binding]; metal-binding site 765952000836 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 765952000837 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765952000838 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952000839 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 765952000840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952000841 ATP binding site [chemical binding]; other site 765952000842 putative Mg++ binding site [ion binding]; other site 765952000843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952000844 nucleotide binding region [chemical binding]; other site 765952000845 ATP-binding site [chemical binding]; other site 765952000846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952000848 active site 765952000849 GTP-binding protein Der; Reviewed; Region: PRK00093 765952000850 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 765952000851 G1 box; other site 765952000852 GTP/Mg2+ binding site [chemical binding]; other site 765952000853 Switch I region; other site 765952000854 G2 box; other site 765952000855 Switch II region; other site 765952000856 G3 box; other site 765952000857 G4 box; other site 765952000858 G5 box; other site 765952000859 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 765952000860 G1 box; other site 765952000861 GTP/Mg2+ binding site [chemical binding]; other site 765952000862 Switch I region; other site 765952000863 G2 box; other site 765952000864 G3 box; other site 765952000865 Switch II region; other site 765952000866 G4 box; other site 765952000867 G5 box; other site 765952000868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765952000869 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 765952000870 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 765952000871 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952000872 structural tetrad; other site 765952000873 FOG: WD40 repeat [General function prediction only]; Region: COG2319 765952000874 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 765952000875 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 765952000876 Sulfate transporter family; Region: Sulfate_transp; pfam00916 765952000877 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 765952000878 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 765952000879 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 765952000880 anti sigma factor interaction site; other site 765952000881 regulatory phosphorylation site [posttranslational modification]; other site 765952000882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952000883 TPR motif; other site 765952000884 binding surface 765952000885 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 765952000886 rRNA interaction site [nucleotide binding]; other site 765952000887 S8 interaction site; other site 765952000888 putative laminin-1 binding site; other site 765952000889 elongation factor Ts; Provisional; Region: tsf; PRK09377 765952000890 UBA/TS-N domain; Region: UBA; pfam00627 765952000891 Elongation factor TS; Region: EF_TS; pfam00889 765952000892 Elongation factor TS; Region: EF_TS; pfam00889 765952000893 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 765952000894 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765952000895 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 765952000896 AAA domain; Region: AAA_14; pfam13173 765952000897 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 765952000898 Bax inhibitor 1 like; Region: BaxI_1; cl17691 765952000899 Deoxyhypusine synthase; Region: DS; cl00826 765952000900 deoxyhypusine synthase; Region: dhys; TIGR00321 765952000901 agmatinase; Region: agmatinase; TIGR01230 765952000902 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 765952000903 putative active site [active] 765952000904 Mn binding site [ion binding]; other site 765952000905 arginine decarboxylase; Provisional; Region: PRK05354 765952000906 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 765952000907 dimer interface [polypeptide binding]; other site 765952000908 active site 765952000909 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765952000910 catalytic residues [active] 765952000911 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 765952000912 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765952000913 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 765952000914 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 765952000915 NAD synthetase; Provisional; Region: PRK13981 765952000916 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 765952000917 multimer interface [polypeptide binding]; other site 765952000918 active site 765952000919 catalytic triad [active] 765952000920 protein interface 1 [polypeptide binding]; other site 765952000921 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 765952000922 homodimer interface [polypeptide binding]; other site 765952000923 NAD binding pocket [chemical binding]; other site 765952000924 ATP binding pocket [chemical binding]; other site 765952000925 Mg binding site [ion binding]; other site 765952000926 active-site loop [active] 765952000927 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 765952000928 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765952000929 catalytic loop [active] 765952000930 iron binding site [ion binding]; other site 765952000931 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 765952000932 FAD binding pocket [chemical binding]; other site 765952000933 FAD binding motif [chemical binding]; other site 765952000934 phosphate binding motif [ion binding]; other site 765952000935 beta-alpha-beta structure motif; other site 765952000936 NAD binding pocket [chemical binding]; other site 765952000937 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 765952000938 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 765952000939 FMN binding site [chemical binding]; other site 765952000940 active site 765952000941 catalytic residues [active] 765952000942 substrate binding site [chemical binding]; other site 765952000943 Methyltransferase domain; Region: Methyltransf_24; pfam13578 765952000944 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 765952000945 TrkA-N domain; Region: TrkA_N; pfam02254 765952000946 TrkA-C domain; Region: TrkA_C; pfam02080 765952000947 TrkA-N domain; Region: TrkA_N; pfam02254 765952000948 TrkA-C domain; Region: TrkA_C; pfam02080 765952000949 Cation transport protein; Region: TrkH; cl17365 765952000950 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 765952000951 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952000952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952000953 S-adenosylmethionine binding site [chemical binding]; other site 765952000954 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 765952000955 Putative Ig domain; Region: He_PIG; pfam05345 765952000956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 765952000957 Phosphotransferase enzyme family; Region: APH; pfam01636 765952000958 active site 765952000959 substrate binding site [chemical binding]; other site 765952000960 ATP binding site [chemical binding]; other site 765952000961 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 765952000962 putative rRNA binding site [nucleotide binding]; other site 765952000963 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952000964 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 765952000965 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 765952000966 NAD binding site [chemical binding]; other site 765952000967 substrate binding site [chemical binding]; other site 765952000968 homodimer interface [polypeptide binding]; other site 765952000969 active site 765952000970 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 765952000971 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 765952000972 substrate binding site; other site 765952000973 tetramer interface; other site 765952000974 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 765952000975 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 765952000976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 765952000977 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 765952000978 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 765952000979 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 765952000980 dimerization interface [polypeptide binding]; other site 765952000981 active site 765952000982 metal binding site [ion binding]; metal-binding site 765952000983 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 765952000984 DNA repair protein RadA; Provisional; Region: PRK11823 765952000985 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 765952000986 Walker A motif/ATP binding site; other site 765952000987 ATP binding site [chemical binding]; other site 765952000988 Walker B motif; other site 765952000989 porphobilinogen deaminase; Provisional; Region: PRK01066 765952000990 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 765952000991 domain interfaces; other site 765952000992 active site 765952000993 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 765952000994 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 765952000995 active site 765952000996 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 765952000997 Protein phosphatase 2C; Region: PP2C; pfam00481 765952000998 active site 765952000999 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 765952001000 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 765952001001 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 765952001002 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 765952001003 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 765952001004 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765952001005 trimer interface [polypeptide binding]; other site 765952001006 active site 765952001007 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765952001008 active site 765952001009 phosphorylation site [posttranslational modification] 765952001010 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 765952001011 DNA binding residues [nucleotide binding] 765952001012 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 765952001013 active site 765952001014 phosphorylation site [posttranslational modification] 765952001015 F-box-like; Region: F-box-like; pfam12937 765952001016 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 765952001017 Clp amino terminal domain; Region: Clp_N; pfam02861 765952001018 Clp amino terminal domain; Region: Clp_N; pfam02861 765952001019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952001020 Walker A motif; other site 765952001021 ATP binding site [chemical binding]; other site 765952001022 Walker B motif; other site 765952001023 arginine finger; other site 765952001024 UvrB/uvrC motif; Region: UVR; pfam02151 765952001025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952001026 Walker A motif; other site 765952001027 ATP binding site [chemical binding]; other site 765952001028 Walker B motif; other site 765952001029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 765952001030 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 765952001031 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 765952001032 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 765952001033 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 765952001034 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952001035 catalytic residue [active] 765952001036 FeS assembly protein SufD; Region: sufD; TIGR01981 765952001037 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 765952001038 FeS assembly ATPase SufC; Region: sufC; TIGR01978 765952001039 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 765952001040 Walker A/P-loop; other site 765952001041 ATP binding site [chemical binding]; other site 765952001042 Q-loop/lid; other site 765952001043 ABC transporter signature motif; other site 765952001044 Walker B; other site 765952001045 D-loop; other site 765952001046 H-loop/switch region; other site 765952001047 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 765952001048 putative ABC transporter; Region: ycf24; CHL00085 765952001049 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765952001050 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952001051 RNA binding surface [nucleotide binding]; other site 765952001052 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 765952001053 active site 765952001054 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 765952001055 active site 765952001056 catalytic residues [active] 765952001057 F-box-like; Region: F-box-like; pfam12937 765952001058 Homeodomain-like domain; Region: HTH_23; cl17451 765952001059 Winged helix-turn helix; Region: HTH_33; pfam13592 765952001060 DDE superfamily endonuclease; Region: DDE_3; pfam13358 765952001061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 765952001062 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001063 PemK-like protein; Region: PemK; pfam02452 765952001064 MULE transposase domain; Region: MULE; pfam10551 765952001065 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952001066 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 765952001067 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952001068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001069 binding surface 765952001070 TPR motif; other site 765952001071 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952001072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001073 binding surface 765952001074 TPR motif; other site 765952001075 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 765952001076 DDE superfamily endonuclease; Region: DDE_4; cl17710 765952001077 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 765952001078 PX-associated; Region: PXB; pfam12828 765952001079 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 765952001080 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952001081 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952001082 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 765952001083 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 765952001084 PX-associated; Region: PXB; pfam12828 765952001085 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 765952001086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952001087 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952001088 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 765952001089 G1 box; other site 765952001090 GTP/Mg2+ binding site [chemical binding]; other site 765952001091 G2 box; other site 765952001092 Switch I region; other site 765952001093 AAA domain; Region: AAA_13; pfam13166 765952001094 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001095 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001096 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001097 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001098 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001099 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001100 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001101 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001102 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001103 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 765952001104 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 765952001105 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 765952001106 catalytic triad [active] 765952001107 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 765952001108 active site 765952001109 Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329 765952001110 aromatic arch; other site 765952001111 DCoH dimer interaction site [polypeptide binding]; other site 765952001112 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 765952001113 DCoH tetramer interaction site [polypeptide binding]; other site 765952001114 substrate binding site [chemical binding]; other site 765952001115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952001116 Q-loop/lid; other site 765952001117 ABC transporter signature motif; other site 765952001118 Walker B; other site 765952001119 D-loop; other site 765952001120 H-loop/switch region; other site 765952001121 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 765952001122 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 765952001123 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 765952001124 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 765952001125 hydroxyglutarate oxidase; Provisional; Region: PRK11728 765952001126 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765952001127 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 765952001128 phosphopeptide binding site; other site 765952001129 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 765952001130 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 765952001131 phosphopeptide binding site; other site 765952001132 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 765952001133 type III secretion system ATPase; Provisional; Region: PRK06315 765952001134 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765952001135 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 765952001136 Walker A motif/ATP binding site; other site 765952001137 Walker B motif; other site 765952001138 type III secretion system protein; Validated; Region: PRK05933 765952001139 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 765952001140 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 765952001141 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 765952001142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952001143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952001144 active site 765952001145 ATP binding site [chemical binding]; other site 765952001146 substrate binding site [chemical binding]; other site 765952001147 activation loop (A-loop); other site 765952001148 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 765952001149 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001150 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001151 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 765952001152 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 765952001153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001154 binding surface 765952001155 TPR motif; other site 765952001156 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001157 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 765952001158 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 765952001159 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 765952001160 Haemolytic domain; Region: Haemolytic; cl00506 765952001161 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 765952001162 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 765952001163 putative carbohydrate kinase; Provisional; Region: PRK10565 765952001164 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 765952001165 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 765952001166 putative substrate binding site [chemical binding]; other site 765952001167 putative ATP binding site [chemical binding]; other site 765952001168 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 765952001169 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 765952001170 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 765952001171 serine hydroxymethyltransferase; Provisional; Region: PRK13580 765952001172 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 765952001173 dimer interface [polypeptide binding]; other site 765952001174 active site 765952001175 glycine-pyridoxal phosphate binding site [chemical binding]; other site 765952001176 folate binding site [chemical binding]; other site 765952001177 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 765952001178 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 765952001179 Putative zinc ribbon domain; Region: DUF164; pfam02591 765952001180 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 765952001181 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 765952001182 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 765952001183 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 765952001184 putative catalytic cysteine [active] 765952001185 gamma-glutamyl kinase; Provisional; Region: PRK05429 765952001186 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 765952001187 nucleotide binding site [chemical binding]; other site 765952001188 homotetrameric interface [polypeptide binding]; other site 765952001189 putative phosphate binding site [ion binding]; other site 765952001190 putative allosteric binding site; other site 765952001191 PUA domain; Region: PUA; pfam01472 765952001192 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 765952001193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952001194 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 765952001195 substrate binding site [chemical binding]; other site 765952001196 active site 765952001197 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 765952001198 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 765952001199 TPP-binding site [chemical binding]; other site 765952001200 dimer interface [polypeptide binding]; other site 765952001201 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765952001202 PYR/PP interface [polypeptide binding]; other site 765952001203 dimer interface [polypeptide binding]; other site 765952001204 TPP binding site [chemical binding]; other site 765952001205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952001206 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 765952001207 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952001208 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 765952001209 NodB motif; other site 765952001210 putative active site [active] 765952001211 putative catalytic site [active] 765952001212 putative Zn binding site [ion binding]; other site 765952001213 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 765952001214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952001215 CCC1-related family of proteins; Region: CCC1_like; cl00278 765952001216 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 765952001217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952001218 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765952001219 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 765952001220 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 765952001221 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 765952001222 GrpE; Region: GrpE; pfam01025 765952001223 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 765952001224 dimer interface [polypeptide binding]; other site 765952001225 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 765952001226 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 765952001227 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 765952001228 nucleotide binding site [chemical binding]; other site 765952001229 NEF interaction site [polypeptide binding]; other site 765952001230 SBD interface [polypeptide binding]; other site 765952001231 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 765952001232 active site clefts [active] 765952001233 zinc binding site [ion binding]; other site 765952001234 dimer interface [polypeptide binding]; other site 765952001235 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 765952001236 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 765952001237 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 765952001238 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 765952001239 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 765952001240 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952001241 Peptidase M16C associated; Region: M16C_assoc; pfam08367 765952001242 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 765952001243 integrase; Provisional; Region: int; PHA02601 765952001244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952001245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952001246 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765952001247 Coenzyme A binding pocket [chemical binding]; other site 765952001248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765952001249 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952001250 nudix motif; other site 765952001251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765952001252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 765952001253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 765952001254 dimerization interface [polypeptide binding]; other site 765952001255 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 765952001256 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 765952001257 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 765952001258 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765952001259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952001260 Walker A/P-loop; other site 765952001261 ATP binding site [chemical binding]; other site 765952001262 Q-loop/lid; other site 765952001263 ABC transporter signature motif; other site 765952001264 Walker B; other site 765952001265 D-loop; other site 765952001266 H-loop/switch region; other site 765952001267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952001268 dimer interface [polypeptide binding]; other site 765952001269 conserved gate region; other site 765952001270 putative PBP binding loops; other site 765952001271 ABC-ATPase subunit interface; other site 765952001272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952001273 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952001274 substrate binding pocket [chemical binding]; other site 765952001275 membrane-bound complex binding site; other site 765952001276 hinge residues; other site 765952001277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765952001278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 765952001279 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 765952001280 dimerization interface [polypeptide binding]; other site 765952001281 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 765952001282 putative homodimer interface [polypeptide binding]; other site 765952001283 putative homotetramer interface [polypeptide binding]; other site 765952001284 putative allosteric switch controlling residues; other site 765952001285 putative metal binding site [ion binding]; other site 765952001286 putative homodimer-homodimer interface [polypeptide binding]; other site 765952001287 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765952001288 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765952001289 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952001290 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952001291 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 765952001292 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 765952001293 active site 765952001294 dimerization interface [polypeptide binding]; other site 765952001295 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 765952001296 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 765952001297 active site 765952001298 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 765952001299 glycyl-tRNA synthetase; Provisional; Region: PRK04173 765952001300 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765952001301 motif 1; other site 765952001302 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 765952001303 active site 765952001304 motif 2; other site 765952001305 motif 3; other site 765952001306 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 765952001307 anticodon binding site; other site 765952001308 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765952001309 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 765952001310 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 765952001311 oligomer interface [polypeptide binding]; other site 765952001312 metal binding site [ion binding]; metal-binding site 765952001313 metal binding site [ion binding]; metal-binding site 765952001314 Cl binding site [ion binding]; other site 765952001315 aspartate ring; other site 765952001316 basic sphincter; other site 765952001317 putative hydrophobic gate; other site 765952001318 periplasmic entrance; other site 765952001319 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 765952001320 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 765952001321 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 765952001322 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001323 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 765952001324 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 765952001325 S17 interaction site [polypeptide binding]; other site 765952001326 S8 interaction site; other site 765952001327 16S rRNA interaction site [nucleotide binding]; other site 765952001328 streptomycin interaction site [chemical binding]; other site 765952001329 23S rRNA interaction site [nucleotide binding]; other site 765952001330 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 765952001331 30S ribosomal protein S7; Validated; Region: PRK05302 765952001332 elongation factor G; Reviewed; Region: PRK12739 765952001333 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 765952001334 G1 box; other site 765952001335 putative GEF interaction site [polypeptide binding]; other site 765952001336 GTP/Mg2+ binding site [chemical binding]; other site 765952001337 Switch I region; other site 765952001338 G2 box; other site 765952001339 G3 box; other site 765952001340 Switch II region; other site 765952001341 G4 box; other site 765952001342 G5 box; other site 765952001343 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 765952001344 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 765952001345 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 765952001346 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 765952001347 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 765952001348 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 765952001349 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 765952001350 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 765952001351 pyruvate phosphate dikinase; Provisional; Region: PRK09279 765952001352 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765952001353 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 765952001354 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 765952001355 AAA domain; Region: AAA_14; pfam13173 765952001356 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 765952001357 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 765952001358 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952001359 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 765952001360 active site 765952001361 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 765952001362 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 765952001363 tandem repeat interface [polypeptide binding]; other site 765952001364 oligomer interface [polypeptide binding]; other site 765952001365 active site residues [active] 765952001366 DNA polymerase I; Provisional; Region: PRK05755 765952001367 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 765952001368 active site 765952001369 metal binding site 1 [ion binding]; metal-binding site 765952001370 putative 5' ssDNA interaction site; other site 765952001371 metal binding site 3; metal-binding site 765952001372 metal binding site 2 [ion binding]; metal-binding site 765952001373 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 765952001374 putative DNA binding site [nucleotide binding]; other site 765952001375 putative metal binding site [ion binding]; other site 765952001376 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 765952001377 active site 765952001378 catalytic site [active] 765952001379 substrate binding site [chemical binding]; other site 765952001380 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 765952001381 active site 765952001382 DNA binding site [nucleotide binding] 765952001383 catalytic site [active] 765952001384 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 765952001385 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 765952001386 CoA-binding site [chemical binding]; other site 765952001387 ATP-binding [chemical binding]; other site 765952001388 transcription termination factor Rho; Provisional; Region: rho; PRK09376 765952001389 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 765952001390 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 765952001391 RNA binding site [nucleotide binding]; other site 765952001392 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 765952001393 multimer interface [polypeptide binding]; other site 765952001394 Walker A motif; other site 765952001395 ATP binding site [chemical binding]; other site 765952001396 Walker B motif; other site 765952001397 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 765952001398 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 765952001399 active site 765952001400 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765952001401 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765952001402 catalytic residues [active] 765952001403 Protein-tyrosine phosphatase; Region: Y_phosphatase; pfam00102 765952001404 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 765952001405 active site 765952001406 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765952001407 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765952001408 catalytic residues [active] 765952001409 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 765952001410 GTP1/OBG; Region: GTP1_OBG; pfam01018 765952001411 Obg GTPase; Region: Obg; cd01898 765952001412 G1 box; other site 765952001413 GTP/Mg2+ binding site [chemical binding]; other site 765952001414 Switch I region; other site 765952001415 G2 box; other site 765952001416 G3 box; other site 765952001417 Switch II region; other site 765952001418 G4 box; other site 765952001419 G5 box; other site 765952001420 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 765952001421 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 765952001422 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 765952001423 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 765952001424 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 765952001425 NAD binding site [chemical binding]; other site 765952001426 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765952001427 C-terminal peptidase (prc); Region: prc; TIGR00225 765952001428 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 765952001429 protein binding site [polypeptide binding]; other site 765952001430 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 765952001431 Catalytic dyad [active] 765952001432 ScpA/B protein; Region: ScpA_ScpB; cl00598 765952001433 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 765952001434 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 765952001435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765952001436 Walker A/P-loop; other site 765952001437 ATP binding site [chemical binding]; other site 765952001438 Q-loop/lid; other site 765952001439 ABC transporter signature motif; other site 765952001440 Walker B; other site 765952001441 D-loop; other site 765952001442 H-loop/switch region; other site 765952001443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 765952001444 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 765952001445 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 765952001446 Walker A/P-loop; other site 765952001447 ATP binding site [chemical binding]; other site 765952001448 Q-loop/lid; other site 765952001449 ABC transporter signature motif; other site 765952001450 Walker B; other site 765952001451 D-loop; other site 765952001452 H-loop/switch region; other site 765952001453 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 765952001454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952001455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952001457 S-adenosylmethionine binding site [chemical binding]; other site 765952001458 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 765952001459 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 765952001460 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952001461 RNA binding surface [nucleotide binding]; other site 765952001462 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 765952001463 active site 765952001464 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 765952001465 putative tRNA-binding site [nucleotide binding]; other site 765952001466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765952001467 catalytic core [active] 765952001468 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 765952001469 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 765952001470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952001471 catalytic residue [active] 765952001472 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 765952001473 NifU-like domain; Region: NifU; cl00484 765952001474 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 765952001475 ADP-ribose binding site [chemical binding]; other site 765952001476 vacuolar-type H(+)-translocating pyrophosphatase; Region: V_PPase; TIGR01104 765952001477 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 765952001478 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765952001479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952001480 Walker A/P-loop; other site 765952001481 ATP binding site [chemical binding]; other site 765952001482 Q-loop/lid; other site 765952001483 ABC transporter signature motif; other site 765952001484 Walker B; other site 765952001485 D-loop; other site 765952001486 H-loop/switch region; other site 765952001487 ABC transporter; Region: ABC_tran_2; pfam12848 765952001488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765952001489 F-box-like; Region: F-box-like; pfam12937 765952001490 F-box-like; Region: F-box-like; pfam12937 765952001491 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952001492 ABC-2 type transporter; Region: ABC2_membrane; cl17235 765952001493 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 765952001494 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 765952001495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952001496 Walker A/P-loop; other site 765952001497 ATP binding site [chemical binding]; other site 765952001498 Q-loop/lid; other site 765952001499 ABC transporter signature motif; other site 765952001500 Walker B; other site 765952001501 D-loop; other site 765952001502 H-loop/switch region; other site 765952001503 oxidoreductase; Region: PLN02485 765952001504 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 765952001505 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 765952001506 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 765952001507 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 765952001508 Recombination protein O N terminal; Region: RecO_N; pfam11967 765952001509 Recombination protein O C terminal; Region: RecO_C; pfam02565 765952001510 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952001511 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765952001512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952001513 RNA binding surface [nucleotide binding]; other site 765952001514 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 765952001515 active site 765952001516 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 765952001517 putative active site [active] 765952001518 dimerization interface [polypeptide binding]; other site 765952001519 putative tRNAtyr binding site [nucleotide binding]; other site 765952001520 hypothetical protein; Provisional; Region: PRK01064 765952001521 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 765952001522 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 765952001523 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 765952001524 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 765952001525 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 765952001526 dimer interface [polypeptide binding]; other site 765952001527 PYR/PP interface [polypeptide binding]; other site 765952001528 TPP binding site [chemical binding]; other site 765952001529 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 765952001530 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 765952001531 TPP-binding site [chemical binding]; other site 765952001532 dimer interface [polypeptide binding]; other site 765952001533 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952001534 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 765952001535 active site 765952001536 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 765952001537 Domain present in PSD-95, Dlg, and ZO-1/2; Region: PDZ; smart00228 765952001538 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 765952001539 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 765952001540 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 765952001541 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 765952001542 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 765952001543 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 765952001544 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 765952001545 active site 765952001546 substrate binding site [chemical binding]; other site 765952001547 Mg2+ binding site [ion binding]; other site 765952001548 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 765952001549 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 765952001550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001551 binding surface 765952001552 TPR motif; other site 765952001553 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 765952001554 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 765952001555 Active site serine [active] 765952001556 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 765952001557 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 765952001558 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 765952001559 active site 765952001560 Zn binding site [ion binding]; other site 765952001561 Uncharacterized conserved protein [Function unknown]; Region: COG2968 765952001562 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 765952001563 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 765952001564 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 765952001565 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 765952001566 ATP-binding site [chemical binding]; other site 765952001567 Sugar specificity; other site 765952001568 Pyrimidine base specificity; other site 765952001569 primosome assembly protein PriA; Validated; Region: PRK05580 765952001570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952001571 ATP binding site [chemical binding]; other site 765952001572 putative Mg++ binding site [ion binding]; other site 765952001573 helicase superfamily c-terminal domain; Region: HELICc; smart00490 765952001574 ATP-binding site [chemical binding]; other site 765952001575 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001576 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001577 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001578 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001579 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765952001580 HSP70 interaction site [polypeptide binding]; other site 765952001581 Beta-lactamase; Region: Beta-lactamase; cl17358 765952001582 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 765952001583 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765952001584 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765952001585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952001586 Walker A/P-loop; other site 765952001587 ATP binding site [chemical binding]; other site 765952001588 Q-loop/lid; other site 765952001589 ABC transporter signature motif; other site 765952001590 Walker B; other site 765952001591 D-loop; other site 765952001592 H-loop/switch region; other site 765952001593 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 765952001594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 765952001595 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 765952001596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952001597 dimer interface [polypeptide binding]; other site 765952001598 conserved gate region; other site 765952001599 putative PBP binding loops; other site 765952001600 ABC-ATPase subunit interface; other site 765952001601 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 765952001602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952001603 dimer interface [polypeptide binding]; other site 765952001604 conserved gate region; other site 765952001605 putative PBP binding loops; other site 765952001606 ABC-ATPase subunit interface; other site 765952001607 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 765952001608 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 765952001609 Walker A/P-loop; other site 765952001610 ATP binding site [chemical binding]; other site 765952001611 Q-loop/lid; other site 765952001612 ABC transporter signature motif; other site 765952001613 Walker B; other site 765952001614 D-loop; other site 765952001615 H-loop/switch region; other site 765952001616 TOBE domain; Region: TOBE_2; pfam08402 765952001617 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 765952001618 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 765952001619 acyl-activating enzyme (AAE) consensus motif; other site 765952001620 putative AMP binding site [chemical binding]; other site 765952001621 putative active site [active] 765952001622 putative CoA binding site [chemical binding]; other site 765952001623 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 765952001624 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 765952001625 dimer interface [polypeptide binding]; other site 765952001626 active site 765952001627 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 765952001628 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952001629 substrate binding site [chemical binding]; other site 765952001630 oxyanion hole (OAH) forming residues; other site 765952001631 trimer interface [polypeptide binding]; other site 765952001632 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 765952001633 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 765952001634 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 765952001635 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 765952001636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952001637 Walker A motif; other site 765952001638 ATP binding site [chemical binding]; other site 765952001639 Walker B motif; other site 765952001640 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 765952001641 HSP70 interaction site [polypeptide binding]; other site 765952001642 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 765952001643 Peptidase family M28; Region: Peptidase_M28; pfam04389 765952001644 metal binding site [ion binding]; metal-binding site 765952001645 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 765952001646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001647 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 765952001648 NAD(P) binding site [chemical binding]; other site 765952001649 active site 765952001650 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 765952001651 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765952001652 acyl-activating enzyme (AAE) consensus motif; other site 765952001653 AMP binding site [chemical binding]; other site 765952001654 active site 765952001655 CoA binding site [chemical binding]; other site 765952001656 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 765952001657 HrpJ-like domain; Region: HrpJ; cl15454 765952001658 Type III secretory pathway, component EscV [Intracellular trafficking and secretion]; Region: EscV; COG4789 765952001659 FHIPEP family; Region: FHIPEP; pfam00771 765952001660 type III secretion system protein; Validated; Region: PRK06298 765952001661 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 765952001662 GTP-binding protein YchF; Reviewed; Region: PRK09601 765952001663 YchF GTPase; Region: YchF; cd01900 765952001664 G1 box; other site 765952001665 GTP/Mg2+ binding site [chemical binding]; other site 765952001666 Switch I region; other site 765952001667 G2 box; other site 765952001668 Switch II region; other site 765952001669 G3 box; other site 765952001670 G4 box; other site 765952001671 G5 box; other site 765952001672 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 765952001673 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 765952001674 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 765952001675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 765952001676 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 765952001677 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 765952001678 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 765952001679 ParB-like nuclease domain; Region: ParB; smart00470 765952001680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765952001681 non-specific DNA binding site [nucleotide binding]; other site 765952001682 salt bridge; other site 765952001683 sequence-specific DNA binding site [nucleotide binding]; other site 765952001684 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952001685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952001686 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952001687 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 765952001688 metal ion-dependent adhesion site (MIDAS); other site 765952001689 von Willebrand factor type A domain; Region: VWA_2; pfam13519 765952001690 metal ion-dependent adhesion site (MIDAS); other site 765952001691 Oxygen tolerance; Region: BatD; pfam13584 765952001692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001693 TPR motif; other site 765952001694 TPR repeat; Region: TPR_11; pfam13414 765952001695 binding surface 765952001696 Bacterial SH3 domain; Region: SH3_3; cl17532 765952001697 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 765952001698 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 765952001699 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 765952001700 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765952001701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952001702 FeS/SAM binding site; other site 765952001703 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 765952001704 23S rRNA interface [nucleotide binding]; other site 765952001705 L3 interface [polypeptide binding]; other site 765952001706 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 765952001707 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952001708 putative catalytic site [active] 765952001709 putative metal binding site [ion binding]; other site 765952001710 putative phosphate binding site [ion binding]; other site 765952001711 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 765952001712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952001713 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 765952001714 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765952001715 hypothetical protein; Validated; Region: PRK00228 765952001716 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 765952001717 mce related protein; Region: MCE; pfam02470 765952001718 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 765952001719 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 765952001720 Walker A/P-loop; other site 765952001721 ATP binding site [chemical binding]; other site 765952001722 Q-loop/lid; other site 765952001723 ABC transporter signature motif; other site 765952001724 Walker B; other site 765952001725 D-loop; other site 765952001726 H-loop/switch region; other site 765952001727 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 765952001728 Permease; Region: Permease; pfam02405 765952001729 Family of unknown function (DUF490); Region: DUF490; pfam04357 765952001730 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 765952001731 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 765952001732 Surface antigen; Region: Bac_surface_Ag; pfam01103 765952001733 Acylphosphatase; Region: Acylphosphatase; pfam00708 765952001734 putative cation:proton antiport protein; Provisional; Region: PRK10669 765952001735 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 765952001736 TrkA-N domain; Region: TrkA_N; pfam02254 765952001737 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 765952001738 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 765952001739 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 765952001740 DEAD-like helicases superfamily; Region: DEXDc; smart00487 765952001741 ATP binding site [chemical binding]; other site 765952001742 Mg++ binding site [ion binding]; other site 765952001743 motif III; other site 765952001744 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952001745 nucleotide binding region [chemical binding]; other site 765952001746 ATP-binding site [chemical binding]; other site 765952001747 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765952001748 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952001749 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952001750 Transporter associated domain; Region: CorC_HlyC; smart01091 765952001751 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 765952001752 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952001753 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952001754 Transporter associated domain; Region: CorC_HlyC; smart01091 765952001755 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 765952001756 trimer interface [polypeptide binding]; other site 765952001757 active site 765952001758 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 765952001759 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952001760 nudix motif; other site 765952001761 Predicted flavoprotein [General function prediction only]; Region: COG0431 765952001762 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 765952001763 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765952001764 HSP70 interaction site [polypeptide binding]; other site 765952001765 Membrane protein of unknown function; Region: DUF360; pfam04020 765952001766 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952001767 Sel1-like repeats; Region: SEL1; smart00671 765952001768 Sel1-like repeats; Region: SEL1; smart00671 765952001769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001770 binding surface 765952001771 TPR motif; other site 765952001772 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952001773 Sel1-like repeats; Region: SEL1; smart00671 765952001774 Sel1-like repeats; Region: SEL1; smart00671 765952001775 Sel1-like repeats; Region: SEL1; smart00671 765952001776 Sel1-like repeats; Region: SEL1; smart00671 765952001777 Sel1-like repeats; Region: SEL1; smart00671 765952001778 Sel1-like repeats; Region: SEL1; smart00671 765952001779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001780 binding surface 765952001781 TPR motif; other site 765952001782 Tetratricopeptide repeat; Region: TPR_16; pfam13432 765952001783 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 765952001784 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 765952001785 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 765952001786 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 765952001787 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 765952001788 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 765952001789 putative active site [active] 765952001790 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 765952001791 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 765952001792 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 765952001793 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 765952001794 active site 765952001795 substrate binding site [chemical binding]; other site 765952001796 metal binding site [ion binding]; metal-binding site 765952001797 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 765952001798 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 765952001799 Flagellin N-methylase; Region: FliB; pfam03692 765952001800 F-box-like; Region: F-box-like; cl02535 765952001801 F-box-like; Region: F-box-like; pfam12937 765952001802 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 765952001803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952001804 Walker A/P-loop; other site 765952001805 ATP binding site [chemical binding]; other site 765952001806 Q-loop/lid; other site 765952001807 ABC transporter signature motif; other site 765952001808 Walker B; other site 765952001809 D-loop; other site 765952001810 H-loop/switch region; other site 765952001811 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 765952001812 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952001813 ABC-ATPase subunit interface; other site 765952001814 dimer interface [polypeptide binding]; other site 765952001815 putative PBP binding regions; other site 765952001816 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 765952001817 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 765952001818 intersubunit interface [polypeptide binding]; other site 765952001819 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765952001820 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765952001821 ring oligomerisation interface [polypeptide binding]; other site 765952001822 ATP/Mg binding site [chemical binding]; other site 765952001823 stacking interactions; other site 765952001824 hinge regions; other site 765952001825 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 765952001826 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 765952001827 dimerization interface [polypeptide binding]; other site 765952001828 active site 765952001829 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 765952001830 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 765952001831 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 765952001832 ligand binding site; other site 765952001833 oligomer interface; other site 765952001834 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 765952001835 N-terminal domain interface [polypeptide binding]; other site 765952001836 sulfate 1 binding site; other site 765952001837 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952001838 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 765952001839 putative active site [active] 765952001840 putative metal binding site [ion binding]; other site 765952001841 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 765952001842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001843 NAD(P) binding site [chemical binding]; other site 765952001844 active site 765952001845 DNA protecting protein DprA; Region: dprA; TIGR00732 765952001846 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 765952001847 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 765952001848 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 765952001849 active site 765952001850 interdomain interaction site; other site 765952001851 putative metal-binding site [ion binding]; other site 765952001852 nucleotide binding site [chemical binding]; other site 765952001853 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 765952001854 domain I; other site 765952001855 DNA binding groove [nucleotide binding] 765952001856 phosphate binding site [ion binding]; other site 765952001857 domain II; other site 765952001858 domain III; other site 765952001859 nucleotide binding site [chemical binding]; other site 765952001860 catalytic site [active] 765952001861 domain IV; other site 765952001862 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 765952001863 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 765952001864 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 765952001865 SWIB/MDM2 domain; Region: SWIB; pfam02201 765952001866 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 765952001867 TIGR02452 family protein; Region: TIGR02452 765952001868 cytidine deaminase, homodimeric; Region: cyt_deam_dimer; TIGR01355 765952001869 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 765952001870 active site 765952001871 catalytic motif [active] 765952001872 Zn binding site [ion binding]; other site 765952001873 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 765952001874 active site 765952001875 catalytic motif [active] 765952001876 Zn binding site [ion binding]; other site 765952001877 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952001878 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 765952001879 cell division protein FtsW; Region: ftsW; TIGR02614 765952001880 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 765952001881 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 765952001882 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 765952001883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952001884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765952001885 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 765952001886 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 765952001887 Mg++ binding site [ion binding]; other site 765952001888 putative catalytic motif [active] 765952001889 putative substrate binding site [chemical binding]; other site 765952001890 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952001891 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 765952001892 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952001893 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 765952001894 Fatty acid desaturase; Region: FA_desaturase; pfam00487 765952001895 Di-iron ligands [ion binding]; other site 765952001896 Predicted methyltransferases [General function prediction only]; Region: COG0313 765952001897 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 765952001898 putative SAM binding site [chemical binding]; other site 765952001899 putative homodimer interface [polypeptide binding]; other site 765952001900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952001901 S-adenosylmethionine binding site [chemical binding]; other site 765952001902 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14095 765952001903 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 765952001904 active site 765952001905 dimer interface [polypeptide binding]; other site 765952001906 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 765952001907 dimer interface [polypeptide binding]; other site 765952001908 active site 765952001909 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 765952001910 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 765952001911 active site 765952001912 Int/Topo IB signature motif; other site 765952001913 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952001914 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952001915 binding surface 765952001916 TPR motif; other site 765952001917 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 765952001918 ApbE family; Region: ApbE; pfam02424 765952001919 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 765952001920 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 765952001921 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 765952001922 homodimer interface [polypeptide binding]; other site 765952001923 NADP binding site [chemical binding]; other site 765952001924 substrate binding site [chemical binding]; other site 765952001925 K+ potassium transporter; Region: K_trans; cl15781 765952001926 Amino acid permease; Region: AA_permease_2; pfam13520 765952001927 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 765952001928 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 765952001929 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 765952001930 RNase E interface [polypeptide binding]; other site 765952001931 trimer interface [polypeptide binding]; other site 765952001932 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 765952001933 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 765952001934 RNase E interface [polypeptide binding]; other site 765952001935 trimer interface [polypeptide binding]; other site 765952001936 active site 765952001937 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 765952001938 putative nucleic acid binding region [nucleotide binding]; other site 765952001939 G-X-X-G motif; other site 765952001940 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 765952001941 RNA binding site [nucleotide binding]; other site 765952001942 domain interface; other site 765952001943 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 765952001944 16S/18S rRNA binding site [nucleotide binding]; other site 765952001945 S13e-L30e interaction site [polypeptide binding]; other site 765952001946 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952001947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952001948 S-adenosylmethionine binding site [chemical binding]; other site 765952001949 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 765952001950 active sites [active] 765952001951 tetramer interface [polypeptide binding]; other site 765952001952 urocanate hydratase; Provisional; Region: PRK05414 765952001953 imidazolonepropionase; Validated; Region: PRK09356 765952001954 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 765952001955 active site 765952001956 formimidoylglutamase; Provisional; Region: PRK13775 765952001957 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 765952001958 putative active site [active] 765952001959 putative metal binding site [ion binding]; other site 765952001960 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 765952001961 Uncharacterized conserved protein [Function unknown]; Region: COG2928 765952001962 Uncharacterized conserved protein [Function unknown]; Region: COG2928 765952001963 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 765952001964 active site 765952001965 DNA binding site [nucleotide binding] 765952001966 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 765952001967 triosephosphate isomerase; Provisional; Region: PRK14565 765952001968 substrate binding site [chemical binding]; other site 765952001969 dimer interface [polypeptide binding]; other site 765952001970 catalytic triad [active] 765952001971 Preprotein translocase SecG subunit; Region: SecG; pfam03840 765952001972 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 765952001973 active site 765952001974 catalytic residues [active] 765952001975 metal binding site [ion binding]; metal-binding site 765952001976 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 765952001977 Heavy-metal-associated domain; Region: HMA; pfam00403 765952001978 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952001979 metal-binding site [ion binding] 765952001980 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952001981 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765952001982 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952001983 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952001984 Domain of unknown function (DUF386); Region: DUF386; cl01047 765952001985 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 765952001986 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 765952001987 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 765952001988 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 765952001989 DNA binding residues [nucleotide binding] 765952001990 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 765952001991 catalytic nucleophile [active] 765952001992 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 765952001993 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 765952001994 catalytic residues [active] 765952001995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952001996 short chain dehydrogenase; Validated; Region: PRK07069 765952001997 NAD(P) binding site [chemical binding]; other site 765952001998 active site 765952001999 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952002000 nudix motif; other site 765952002001 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 765952002002 nucleotide binding site/active site [active] 765952002003 HIT family signature motif; other site 765952002004 catalytic residue [active] 765952002005 hypothetical protein; Provisional; Region: PRK04233 765952002006 SEC-C motif; Region: SEC-C; pfam02810 765952002007 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952002008 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 765952002009 Resolvase, N terminal domain; Region: Resolvase; pfam00239 765952002010 Recombinase; Region: Recombinase; pfam07508 765952002011 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 765952002012 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002013 MULE transposase domain; Region: MULE; pfam10551 765952002014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002015 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952002016 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 765952002017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 765952002018 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 765952002019 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 765952002020 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 765952002021 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 765952002022 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002023 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 765952002024 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 765952002025 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 765952002026 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 765952002027 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002028 MULE transposase domain; Region: MULE; pfam10551 765952002029 Zeta toxin; Region: Zeta_toxin; pfam06414 765952002030 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 765952002031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952002032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765952002033 active site 765952002034 catalytic tetrad [active] 765952002035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002036 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 765952002037 NAD(P) binding site [chemical binding]; other site 765952002038 active site 765952002039 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 765952002040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952002041 NmrA-like family; Region: NmrA; pfam05368 765952002042 NAD(P) binding site [chemical binding]; other site 765952002043 active site 765952002044 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 765952002045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952002046 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 765952002047 putative substrate translocation pore; other site 765952002048 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952002049 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 765952002050 putative active site [active] 765952002051 putative metal binding site [ion binding]; other site 765952002052 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952002053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952002054 F-box-like; Region: F-box-like; cl02535 765952002055 Small integral membrane protein [Function unknown]; Region: COG5487; cl17674 765952002056 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 765952002057 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 765952002058 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 765952002059 putative NAD(P) binding site [chemical binding]; other site 765952002060 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 765952002061 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 765952002062 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765952002063 active site 765952002064 catalytic site [active] 765952002065 substrate binding site [chemical binding]; other site 765952002066 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 765952002067 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 765952002068 acyl carrier protein; Provisional; Region: acpP; PRK00982 765952002069 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 765952002070 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 765952002071 NAD(P) binding site [chemical binding]; other site 765952002072 homotetramer interface [polypeptide binding]; other site 765952002073 homodimer interface [polypeptide binding]; other site 765952002074 active site 765952002075 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 765952002076 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 765952002077 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 765952002078 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 765952002079 dimer interface [polypeptide binding]; other site 765952002080 active site 765952002081 CoA binding pocket [chemical binding]; other site 765952002082 recombination protein RecR; Reviewed; Region: recR; PRK00076 765952002083 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 765952002084 putative active site [active] 765952002085 putative metal-binding site [ion binding]; other site 765952002086 tetramer interface [polypeptide binding]; other site 765952002087 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 765952002088 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 765952002089 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 765952002090 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 765952002091 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 765952002092 Surface antigen; Region: Bac_surface_Ag; pfam01103 765952002093 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 765952002094 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 765952002095 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 765952002096 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 765952002097 trimer interface [polypeptide binding]; other site 765952002098 active site 765952002099 UDP-GlcNAc binding site [chemical binding]; other site 765952002100 lipid binding site [chemical binding]; lipid-binding site 765952002101 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 765952002102 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 765952002103 active site 765952002104 homotetramer interface [polypeptide binding]; other site 765952002105 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 765952002106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952002107 active site 765952002108 motif I; other site 765952002109 motif II; other site 765952002110 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952002111 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 765952002112 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 765952002113 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 765952002114 Autotransporter beta-domain; Region: Autotransporter; smart00869 765952002115 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002116 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 765952002117 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 765952002118 DNA binding site [nucleotide binding] 765952002119 catalytic residue [active] 765952002120 H2TH interface [polypeptide binding]; other site 765952002121 putative catalytic residues [active] 765952002122 turnover-facilitating residue; other site 765952002123 intercalation triad [nucleotide binding]; other site 765952002124 8OG recognition residue [nucleotide binding]; other site 765952002125 putative reading head residues; other site 765952002126 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 765952002127 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 765952002128 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 765952002129 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 765952002130 HIGH motif; other site 765952002131 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 765952002132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952002133 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952002134 active site 765952002135 KMSKS motif; other site 765952002136 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 765952002137 tRNA binding surface [nucleotide binding]; other site 765952002138 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 765952002139 Ligand Binding Site [chemical binding]; other site 765952002140 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 765952002141 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765952002142 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952002143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002144 S-adenosylmethionine binding site [chemical binding]; other site 765952002145 ribonuclease R; Region: RNase_R; TIGR02063 765952002146 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 765952002147 RNB domain; Region: RNB; pfam00773 765952002148 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 765952002149 RNA binding site [nucleotide binding]; other site 765952002150 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 765952002151 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 765952002152 generic binding surface II; other site 765952002153 generic binding surface I; other site 765952002154 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 765952002155 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 765952002156 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 765952002157 TPP-binding site; other site 765952002158 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 765952002159 PYR/PP interface [polypeptide binding]; other site 765952002160 dimer interface [polypeptide binding]; other site 765952002161 TPP binding site [chemical binding]; other site 765952002162 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952002163 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 765952002164 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 765952002165 Chlamydia cysteine-rich outer membrane protein 6; Region: Chlam_OMP6; pfam03504 765952002166 Domain of unknown function DUF11; Region: DUF11; pfam01345 765952002167 Transglutaminase family, C-terminal ig like domain; Region: Transglut_C; pfam00927 765952002168 Domain of unknown function DUF11; Region: DUF11; cl17728 765952002169 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 765952002170 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 765952002171 catalytic Zn binding site [ion binding]; other site 765952002172 structural Zn binding site [ion binding]; other site 765952002173 NAD(P) binding site [chemical binding]; other site 765952002174 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 765952002175 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 765952002176 FAD binding domain; Region: FAD_binding_4; pfam01565 765952002177 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 765952002178 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 765952002179 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 765952002180 active site 765952002181 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 765952002182 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 765952002183 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952002184 Fatty acid desaturase; Region: FA_desaturase; pfam00487 765952002185 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 765952002186 putative di-iron ligands [ion binding]; other site 765952002187 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 765952002188 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 765952002189 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 765952002190 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 765952002191 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 765952002192 dihydropteroate synthase; Region: DHPS; TIGR01496 765952002193 substrate binding pocket [chemical binding]; other site 765952002194 dimer interface [polypeptide binding]; other site 765952002195 inhibitor binding site; inhibition site 765952002196 Uncharacterized conserved protein [Function unknown]; Region: COG1624 765952002197 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 765952002198 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 765952002199 RNA methyltransferase, RsmE family; Region: TIGR00046 765952002200 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 765952002201 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 765952002202 domain interfaces; other site 765952002203 active site 765952002204 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765952002205 acyl-activating enzyme (AAE) consensus motif; other site 765952002206 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 765952002207 AMP binding site [chemical binding]; other site 765952002208 active site 765952002209 CoA binding site [chemical binding]; other site 765952002210 C-terminal putative kinase domain of FAM20 (family with sequence similarity 20), Drosophila Four-jointed (Fj), and related proteins; Region: FAM20_C_like; cl05973 765952002211 putative catalytic residues [active] 765952002212 putative catalytic loop [active] 765952002213 putative metal binding site [ion binding]; other site 765952002214 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 765952002215 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002216 S-adenosylmethionine binding site [chemical binding]; other site 765952002217 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 765952002218 ribonuclease Y; Region: RNase_Y; TIGR03319 765952002219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765952002220 Zn2+ binding site [ion binding]; other site 765952002221 Mg2+ binding site [ion binding]; other site 765952002222 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952002223 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 765952002224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952002225 Transporter associated domain; Region: CorC_HlyC; smart01091 765952002226 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 765952002227 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 765952002228 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952002229 Sel1-like repeats; Region: SEL1; smart00671 765952002230 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952002231 Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731 765952002232 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 765952002233 nucleoside/Zn binding site; other site 765952002234 dimer interface [polypeptide binding]; other site 765952002235 catalytic motif [active] 765952002236 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 765952002237 adenylate kinase; Reviewed; Region: adk; PRK00279 765952002238 AMP-binding site [chemical binding]; other site 765952002239 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 765952002240 F-box-like; Region: F-box-like; pfam12937 765952002241 inositol phosphate phosphatase SopB; Provisional; Region: PRK15378 765952002242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952002243 binding surface 765952002244 TPR motif; other site 765952002245 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 765952002246 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 765952002247 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 765952002248 active site 765952002249 substrate-binding site [chemical binding]; other site 765952002250 metal-binding site [ion binding] 765952002251 GTP binding site [chemical binding]; other site 765952002252 rod shape-determining protein MreB; Provisional; Region: PRK13927 765952002253 MreB and similar proteins; Region: MreB_like; cd10225 765952002254 nucleotide binding site [chemical binding]; other site 765952002255 Mg binding site [ion binding]; other site 765952002256 putative protofilament interaction site [polypeptide binding]; other site 765952002257 RodZ interaction site [polypeptide binding]; other site 765952002258 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 765952002259 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 765952002260 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 765952002261 ATP binding site [chemical binding]; other site 765952002262 putative Mg++ binding site [ion binding]; other site 765952002263 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952002264 nucleotide binding region [chemical binding]; other site 765952002265 ATP-binding site [chemical binding]; other site 765952002266 trigger factor; Provisional; Region: tig; PRK01490 765952002267 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 765952002268 Clp protease; Region: CLP_protease; pfam00574 765952002269 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 765952002270 oligomer interface [polypeptide binding]; other site 765952002271 active site residues [active] 765952002272 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 765952002273 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 765952002274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002275 Walker A motif; other site 765952002276 ATP binding site [chemical binding]; other site 765952002277 Walker B motif; other site 765952002278 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 765952002279 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 765952002280 catalytic core [active] 765952002281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952002282 Coenzyme A binding pocket [chemical binding]; other site 765952002283 intracellular protease, PfpI family; Region: PfpI; TIGR01382 765952002284 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 765952002285 proposed catalytic triad [active] 765952002286 conserved cys residue [active] 765952002287 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 765952002288 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 765952002289 putative DNA binding site [nucleotide binding]; other site 765952002290 putative homodimer interface [polypeptide binding]; other site 765952002291 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 765952002292 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 765952002293 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 765952002294 active site 765952002295 DNA binding site [nucleotide binding] 765952002296 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 765952002297 DNA binding site [nucleotide binding] 765952002298 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 765952002299 nucleotide binding site [chemical binding]; other site 765952002300 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 765952002301 catalytic center binding site [active] 765952002302 ATP binding site [chemical binding]; other site 765952002303 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 765952002304 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 765952002305 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 765952002306 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 765952002307 Walker A/P-loop; other site 765952002308 ATP binding site [chemical binding]; other site 765952002309 Q-loop/lid; other site 765952002310 ABC transporter signature motif; other site 765952002311 Walker B; other site 765952002312 D-loop; other site 765952002313 H-loop/switch region; other site 765952002314 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 765952002315 recombination factor protein RarA; Reviewed; Region: PRK13342 765952002316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002317 Walker A motif; other site 765952002318 ATP binding site [chemical binding]; other site 765952002319 Walker B motif; other site 765952002320 arginine finger; other site 765952002321 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 765952002322 Peptidase family M48; Region: Peptidase_M48; pfam01435 765952002323 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 765952002324 Beta-lactamase; Region: Beta-lactamase; pfam00144 765952002325 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 765952002326 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 765952002327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952002328 active site 765952002329 motif I; other site 765952002330 motif II; other site 765952002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952002332 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952002333 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002334 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002335 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002336 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002337 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002338 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002339 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002340 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002341 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002342 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002343 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 765952002344 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002345 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002346 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002347 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002348 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002349 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002350 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002351 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002352 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 765952002353 ATP-binding site [chemical binding]; other site 765952002354 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002355 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002356 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002357 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002358 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002359 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002361 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002362 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002363 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002364 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002365 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002366 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002367 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002368 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002369 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002370 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002371 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 765952002372 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 765952002373 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 765952002374 amphipathic channel; other site 765952002375 Asn-Pro-Ala signature motifs; other site 765952002376 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 765952002377 F-box-like; Region: F-box-like; pfam12937 765952002378 F-box-like; Region: F-box-like; pfam12937 765952002379 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 765952002380 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 765952002381 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 765952002382 methionine sulfoxide reductase A; Provisional; Region: PRK14054 765952002383 RNB domain; Region: RNB; pfam00773 765952002384 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 765952002385 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952002386 RNA binding site [nucleotide binding]; other site 765952002387 Cytochrome c [Energy production and conversion]; Region: COG3258 765952002388 Cytochrome c; Region: Cytochrom_C; pfam00034 765952002389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952002390 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952002391 substrate binding pocket [chemical binding]; other site 765952002392 membrane-bound complex binding site; other site 765952002393 hinge residues; other site 765952002394 Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222 765952002395 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 765952002396 homodimer interface [polypeptide binding]; other site 765952002397 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 765952002398 active site pocket [active] 765952002399 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002400 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002401 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002402 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002403 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002404 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002405 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002406 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002407 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002408 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002409 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002410 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002411 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002412 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 765952002413 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952002414 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952002415 Beta-lactamase; Region: Beta-lactamase; cl17358 765952002416 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 765952002417 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 765952002418 Cupin; Region: Cupin_1; smart00835 765952002419 Cupin; Region: Cupin_1; smart00835 765952002420 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 765952002421 fumarate hydratase; Reviewed; Region: fumC; PRK00485 765952002422 Class II fumarases; Region: Fumarase_classII; cd01362 765952002423 active site 765952002424 tetramer interface [polypeptide binding]; other site 765952002425 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952002426 RHS Repeat; Region: RHS_repeat; cl11982 765952002427 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952002428 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 765952002429 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 765952002430 active site 765952002431 Zn binding site [ion binding]; other site 765952002432 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 765952002433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952002434 active site 765952002435 phosphorylation site [posttranslational modification] 765952002436 intermolecular recognition site; other site 765952002437 dimerization interface [polypeptide binding]; other site 765952002438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002439 Walker A motif; other site 765952002440 ATP binding site [chemical binding]; other site 765952002441 Walker B motif; other site 765952002442 arginine finger; other site 765952002443 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 765952002444 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 765952002445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765952002446 dimer interface [polypeptide binding]; other site 765952002447 phosphorylation site [posttranslational modification] 765952002448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952002449 ATP binding site [chemical binding]; other site 765952002450 Mg2+ binding site [ion binding]; other site 765952002451 G-X-G motif; other site 765952002452 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 765952002453 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 765952002454 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952002455 RNA binding surface [nucleotide binding]; other site 765952002456 Major royal jelly protein; Region: MRJP; pfam03022 765952002457 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 765952002458 MviN-like protein; Region: MVIN; pfam03023 765952002459 endonuclease IV; Provisional; Region: PRK01060 765952002460 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 765952002461 AP (apurinic/apyrimidinic) site pocket; other site 765952002462 DNA interaction; other site 765952002463 Metal-binding active site; metal-binding site 765952002464 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 765952002465 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 765952002466 putative dimer interface [polypeptide binding]; other site 765952002467 putative anticodon binding site; other site 765952002468 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 765952002469 homodimer interface [polypeptide binding]; other site 765952002470 motif 1; other site 765952002471 motif 2; other site 765952002472 active site 765952002473 motif 3; other site 765952002474 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765952002475 Catalytic site [active] 765952002476 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 765952002477 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 765952002478 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 765952002479 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 765952002480 active site 765952002481 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 765952002482 Isochorismatase family; Region: Isochorismatase; pfam00857 765952002483 catalytic triad [active] 765952002484 metal binding site [ion binding]; metal-binding site 765952002485 conserved cis-peptide bond; other site 765952002486 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 765952002487 ArsC family; Region: ArsC; pfam03960 765952002488 putative ArsC-like catalytic residues; other site 765952002489 putative TRX-like catalytic residues [active] 765952002490 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 765952002491 Cation efflux family; Region: Cation_efflux; pfam01545 765952002492 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 765952002493 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 765952002494 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 765952002495 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 765952002496 Protein tyrosine phosphatase, catalytic domain; Region: PTPc; smart00194 765952002497 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cd00047 765952002498 active site 765952002499 peptide chain release factor 2; Validated; Region: prfB; PRK00578 765952002500 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 765952002501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765952002502 dimerization interface [polypeptide binding]; other site 765952002503 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952002504 dimer interface [polypeptide binding]; other site 765952002505 putative CheW interface [polypeptide binding]; other site 765952002506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765952002507 dimerization interface [polypeptide binding]; other site 765952002508 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952002509 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952002510 dimer interface [polypeptide binding]; other site 765952002511 putative CheW interface [polypeptide binding]; other site 765952002512 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 765952002513 active site 765952002514 multimer interface [polypeptide binding]; other site 765952002515 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 765952002516 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 765952002517 glutamine binding [chemical binding]; other site 765952002518 catalytic triad [active] 765952002519 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 765952002520 active site 765952002521 multimer interface [polypeptide binding]; other site 765952002522 isocitrate lyase; Provisional; Region: PRK15063 765952002523 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 765952002524 tetramer interface [polypeptide binding]; other site 765952002525 active site 765952002526 Mg2+/Mn2+ binding site [ion binding]; other site 765952002527 malate synthase A; Region: malate_syn_A; TIGR01344 765952002528 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 765952002529 active site 765952002530 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 765952002531 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 765952002532 dimerization interface [polypeptide binding]; other site 765952002533 DPS ferroxidase diiron center [ion binding]; other site 765952002534 ion pore; other site 765952002535 Dodecin; Region: Dodecin; pfam07311 765952002536 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 765952002537 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 765952002538 putative tRNA-binding site [nucleotide binding]; other site 765952002539 B3/4 domain; Region: B3_4; pfam03483 765952002540 tRNA synthetase B5 domain; Region: B5; smart00874 765952002541 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 765952002542 dimer interface [polypeptide binding]; other site 765952002543 motif 1; other site 765952002544 motif 3; other site 765952002545 motif 2; other site 765952002546 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 765952002547 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952002548 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 765952002549 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765952002550 DNA binding site [nucleotide binding] 765952002551 active site 765952002552 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 765952002553 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 765952002554 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 765952002555 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 765952002556 NAD(P) binding site [chemical binding]; other site 765952002557 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 765952002558 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 765952002559 substrate-cofactor binding pocket; other site 765952002560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952002561 catalytic residue [active] 765952002562 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 765952002563 Domain interface; other site 765952002564 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 765952002565 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 765952002566 BON domain; Region: BON; pfam04972 765952002567 BON domain; Region: BON; pfam04972 765952002568 pyruvate dehydrogenase; Provisional; Region: PRK09124 765952002569 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 765952002570 PYR/PP interface [polypeptide binding]; other site 765952002571 dimer interface [polypeptide binding]; other site 765952002572 tetramer interface [polypeptide binding]; other site 765952002573 TPP binding site [chemical binding]; other site 765952002574 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 765952002575 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 765952002576 TPP-binding site [chemical binding]; other site 765952002577 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 765952002578 Protein of unknown function DUF72; Region: DUF72; pfam01904 765952002579 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002580 MULE transposase domain; Region: MULE; pfam10551 765952002581 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952002582 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952002583 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 765952002584 RHS Repeat; Region: RHS_repeat; cl11982 765952002585 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002586 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952002587 F-box-like; Region: F-box-like; pfam12937 765952002588 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 765952002589 FAD binding domain; Region: FAD_binding_4; pfam01565 765952002590 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 765952002591 Cysteine-rich domain; Region: CCG; pfam02754 765952002592 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 765952002593 mercuric reductase; Validated; Region: PRK06370 765952002594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952002595 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952002596 succinylarginine dihydrolase; Provisional; Region: PRK13281 765952002597 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 765952002598 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 765952002599 NAD(P) binding site [chemical binding]; other site 765952002600 catalytic residues [active] 765952002601 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 765952002602 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 765952002603 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 765952002604 acetylornithine aminotransferase; Provisional; Region: PRK02627 765952002605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952002606 catalytic residue [active] 765952002607 hypothetical protein; Provisional; Region: PRK07338 765952002608 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 765952002609 metal binding site [ion binding]; metal-binding site 765952002610 dimer interface [polypeptide binding]; other site 765952002611 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 765952002612 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 765952002613 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 765952002614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952002615 binding surface 765952002616 TPR motif; other site 765952002617 TPR repeat; Region: TPR_11; pfam13414 765952002618 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952002619 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 765952002620 putative binding surface; other site 765952002621 active site 765952002622 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 765952002623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952002624 ATP binding site [chemical binding]; other site 765952002625 Mg2+ binding site [ion binding]; other site 765952002626 G-X-G motif; other site 765952002627 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952002628 Response regulator receiver domain; Region: Response_reg; pfam00072 765952002629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952002630 active site 765952002631 phosphorylation site [posttranslational modification] 765952002632 intermolecular recognition site; other site 765952002633 dimerization interface [polypeptide binding]; other site 765952002634 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 765952002635 substrate binding site [chemical binding]; other site 765952002636 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765952002637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952002638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952002639 putative substrate translocation pore; other site 765952002640 DNA primase; Validated; Region: dnaG; PRK05667 765952002641 CHC2 zinc finger; Region: zf-CHC2; pfam01807 765952002642 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 765952002643 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 765952002644 active site 765952002645 metal binding site [ion binding]; metal-binding site 765952002646 interdomain interaction site; other site 765952002647 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 765952002648 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002649 active site 765952002650 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 765952002651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952002652 FeS/SAM binding site; other site 765952002653 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 765952002654 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 765952002655 GIY-YIG motif/motif A; other site 765952002656 active site 765952002657 catalytic site [active] 765952002658 putative DNA binding site [nucleotide binding]; other site 765952002659 metal binding site [ion binding]; metal-binding site 765952002660 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 765952002661 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 765952002662 DNA binding site [nucleotide binding] 765952002663 ResB-like family; Region: ResB; pfam05140 765952002664 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 765952002665 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 765952002666 TPP-binding site [chemical binding]; other site 765952002667 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 765952002668 dimer interface [polypeptide binding]; other site 765952002669 PYR/PP interface [polypeptide binding]; other site 765952002670 TPP binding site [chemical binding]; other site 765952002671 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 765952002672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765952002673 E3 interaction surface; other site 765952002674 lipoyl attachment site [posttranslational modification]; other site 765952002675 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 765952002676 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 765952002677 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952002678 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952002679 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952002680 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002681 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 765952002682 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765952002683 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 765952002684 NAD(P) binding site [chemical binding]; other site 765952002685 catalytic residues [active] 765952002686 Uncharacterized conserved protein [Function unknown]; Region: COG1359 765952002687 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 765952002688 trimer interface [polypeptide binding]; other site 765952002689 putative Zn binding site [ion binding]; other site 765952002690 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 765952002691 classical (c) SDRs; Region: SDR_c; cd05233 765952002692 NAD(P) binding site [chemical binding]; other site 765952002693 active site 765952002694 Major royal jelly protein; Region: MRJP; pfam03022 765952002695 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 765952002696 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 765952002697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765952002698 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 765952002699 catalytic loop [active] 765952002700 iron binding site [ion binding]; other site 765952002701 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 765952002702 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 765952002703 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 765952002704 homotetramer interface [polypeptide binding]; other site 765952002705 ligand binding site [chemical binding]; other site 765952002706 catalytic site [active] 765952002707 NAD binding site [chemical binding]; other site 765952002708 chromosomal replication initiation protein; Provisional; Region: PRK12422 765952002709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952002710 Walker A motif; other site 765952002711 ATP binding site [chemical binding]; other site 765952002712 Walker B motif; other site 765952002713 arginine finger; other site 765952002714 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 765952002715 DnaA box-binding interface [nucleotide binding]; other site 765952002716 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 765952002717 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 765952002718 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952002719 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952002720 active site 765952002721 ATP binding site [chemical binding]; other site 765952002722 substrate binding site [chemical binding]; other site 765952002723 activation loop (A-loop); other site 765952002724 Uncharacterized conserved protein [Function unknown]; Region: COG1262 765952002725 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 765952002726 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 765952002727 Low molecular weight phosphatase family; Region: LMWPc; cd00115 765952002728 active site 765952002729 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 765952002730 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765952002731 inhibitor-cofactor binding pocket; inhibition site 765952002732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952002733 catalytic residue [active] 765952002734 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 765952002735 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 765952002736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952002737 motif II; other site 765952002738 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 765952002739 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765952002740 motif 1; other site 765952002741 dimer interface [polypeptide binding]; other site 765952002742 active site 765952002743 motif 2; other site 765952002744 motif 3; other site 765952002745 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 765952002746 anticodon binding site; other site 765952002747 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 765952002748 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 765952002749 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 765952002750 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 765952002751 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 765952002752 23S rRNA binding site [nucleotide binding]; other site 765952002753 L21 binding site [polypeptide binding]; other site 765952002754 L13 binding site [polypeptide binding]; other site 765952002755 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 765952002756 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 765952002757 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 765952002758 dimer interface [polypeptide binding]; other site 765952002759 motif 1; other site 765952002760 active site 765952002761 motif 2; other site 765952002762 motif 3; other site 765952002763 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 765952002764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952002765 RNA binding surface [nucleotide binding]; other site 765952002766 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 765952002767 active site 765952002768 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765952002769 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 765952002770 putative active site [active] 765952002771 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 765952002772 AAA domain; Region: AAA_26; pfam13500 765952002773 DRTGG domain; Region: DRTGG; pfam07085 765952002774 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 765952002775 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 765952002776 homodimer interface [polypeptide binding]; other site 765952002777 metal binding site [ion binding]; metal-binding site 765952002778 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 765952002779 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 765952002780 nudix motif; other site 765952002781 Methyltransferase domain; Region: Methyltransf_23; pfam13489 765952002782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002783 S-adenosylmethionine binding site [chemical binding]; other site 765952002784 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 765952002785 dimer interface [polypeptide binding]; other site 765952002786 active site 765952002787 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 765952002788 Ligand Binding Site [chemical binding]; other site 765952002789 Molecular Tunnel; other site 765952002790 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 765952002791 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765952002792 HIGH motif; other site 765952002793 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 765952002794 active site 765952002795 KMSKS motif; other site 765952002796 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 765952002797 tRNA binding surface [nucleotide binding]; other site 765952002798 anticodon binding site; other site 765952002799 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952002800 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952002801 active site 765952002802 ATP binding site [chemical binding]; other site 765952002803 substrate binding site [chemical binding]; other site 765952002804 activation loop (A-loop); other site 765952002805 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952002806 substrate binding site [chemical binding]; other site 765952002807 activation loop (A-loop); other site 765952002808 Modified RING finger domain; Region: Ubox; smart00504 765952002809 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765952002810 MgtE intracellular N domain; Region: MgtE_N; pfam03448 765952002811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765952002812 Divalent cation transporter; Region: MgtE; pfam01769 765952002813 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 765952002814 active site 765952002815 catalytic residues [active] 765952002816 metal binding site [ion binding]; metal-binding site 765952002817 Uncharacterized conserved protein [Function unknown]; Region: COG3350 765952002818 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 765952002819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952002820 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765952002821 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952002822 BON domain; Region: BON; pfam04972 765952002823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952002824 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 765952002825 Putative glucoamylase; Region: Glycoamylase; pfam10091 765952002826 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 765952002827 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 765952002828 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 765952002829 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 765952002830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002831 S-adenosylmethionine binding site [chemical binding]; other site 765952002832 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952002833 putative catalytic site [active] 765952002834 putative metal binding site [ion binding]; other site 765952002835 putative phosphate binding site [ion binding]; other site 765952002836 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 765952002837 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 765952002838 NAD binding site [chemical binding]; other site 765952002839 homodimer interface [polypeptide binding]; other site 765952002840 active site 765952002841 substrate binding site [chemical binding]; other site 765952002842 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 765952002843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765952002844 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 765952002845 homodimer interface [polypeptide binding]; other site 765952002846 active site 765952002847 putative chemical substrate binding site [chemical binding]; other site 765952002848 metal binding site [ion binding]; metal-binding site 765952002849 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 765952002850 MepB protein; Region: MepB; cl01985 765952002851 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 765952002852 dimerization interface [polypeptide binding]; other site 765952002853 metal binding site [ion binding]; metal-binding site 765952002854 DNA-binding domain found in transcription regulators in plants such as APETALA2 and EREBP (ethylene responsive element binding protein). In EREBPs the domain specifically binds to the 11bp GCC box of the ethylene response element (ERE), a promotor...; Region: AP2; cl00033 765952002855 DNA binding site [nucleotide binding] 765952002856 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952002857 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 765952002858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002859 S-adenosylmethionine binding site [chemical binding]; other site 765952002860 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 765952002861 Divergent AAA domain; Region: AAA_4; pfam04326 765952002862 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 765952002863 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 765952002864 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 765952002865 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 765952002866 ring oligomerisation interface [polypeptide binding]; other site 765952002867 ATP/Mg binding site [chemical binding]; other site 765952002868 stacking interactions; other site 765952002869 hinge regions; other site 765952002870 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 765952002871 oligomerisation interface [polypeptide binding]; other site 765952002872 mobile loop; other site 765952002873 roof hairpin; other site 765952002874 oligoendopeptidase F; Region: pepF; TIGR00181 765952002875 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 765952002876 active site 765952002877 Zn binding site [ion binding]; other site 765952002878 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 765952002879 dimerization domain swap beta strand [polypeptide binding]; other site 765952002880 regulatory protein interface [polypeptide binding]; other site 765952002881 active site 765952002882 regulatory phosphorylation site [posttranslational modification]; other site 765952002883 Bifunctional nuclease; Region: DNase-RNase; pfam02577 765952002884 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 765952002885 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765952002886 active site 765952002887 dimer interface [polypeptide binding]; other site 765952002888 Uncharacterized conserved protein [Function unknown]; Region: COG0327 765952002889 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 765952002890 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 765952002891 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 765952002892 active site 765952002893 HIGH motif; other site 765952002894 dimer interface [polypeptide binding]; other site 765952002895 KMSKS motif; other site 765952002896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 765952002897 RNA binding surface [nucleotide binding]; other site 765952002898 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 765952002899 IHF - DNA interface [nucleotide binding]; other site 765952002900 IHF dimer interface [polypeptide binding]; other site 765952002901 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 765952002902 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 765952002903 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 765952002904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 765952002905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 765952002906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952002907 Walker A/P-loop; other site 765952002908 ATP binding site [chemical binding]; other site 765952002909 Q-loop/lid; other site 765952002910 ABC transporter signature motif; other site 765952002911 Walker B; other site 765952002912 D-loop; other site 765952002913 H-loop/switch region; other site 765952002914 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 765952002915 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 765952002916 GatB domain; Region: GatB_Yqey; pfam02637 765952002917 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 765952002918 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 765952002919 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 765952002920 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 765952002921 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 765952002922 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 765952002923 DNA binding site [nucleotide binding] 765952002924 active site 765952002925 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 765952002926 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 765952002927 active site 765952002928 homodimer interface [polypeptide binding]; other site 765952002929 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952002930 bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: PRK14573 765952002931 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952002932 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765952002933 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 765952002934 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 765952002935 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 765952002936 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 765952002937 active site 765952002938 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 765952002939 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 765952002940 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 765952002941 KH domain; Region: KH_4; pfam13083 765952002942 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 765952002943 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765952002944 dimer interface [polypeptide binding]; other site 765952002945 ssDNA binding site [nucleotide binding]; other site 765952002946 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765952002947 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 765952002948 anti sigma factor interaction site; other site 765952002949 regulatory phosphorylation site [posttranslational modification]; other site 765952002950 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 765952002951 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 765952002952 Predicted flavoprotein [General function prediction only]; Region: COG0431 765952002953 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 765952002954 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 765952002955 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 765952002956 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 765952002957 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 765952002958 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 765952002959 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 765952002960 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 765952002961 active site 765952002962 (T/H)XGH motif; other site 765952002963 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 765952002964 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 765952002965 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 765952002966 dimer interface [polypeptide binding]; other site 765952002967 active site 765952002968 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 765952002969 active site 765952002970 Ap4A binding cleft/pocket [chemical binding]; other site 765952002971 P4 phosphate binding site; other site 765952002972 nudix motif; other site 765952002973 putative P2/P3 phosphate binding site [ion binding]; other site 765952002974 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 765952002975 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 765952002976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952002977 catalytic residue [active] 765952002978 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 765952002979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952002980 S-adenosylmethionine binding site [chemical binding]; other site 765952002981 AAA domain; Region: AAA_26; pfam13500 765952002982 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 765952002983 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 765952002984 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 765952002985 inhibitor-cofactor binding pocket; inhibition site 765952002986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952002987 catalytic residue [active] 765952002988 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 765952002989 F-box-like; Region: F-box-like; cl02535 765952002990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 765952002991 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 765952002992 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 765952002993 NADP binding site [chemical binding]; other site 765952002994 homopentamer interface [polypeptide binding]; other site 765952002995 substrate binding site [chemical binding]; other site 765952002996 active site 765952002997 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 765952002998 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 765952002999 putative ribose interaction site [chemical binding]; other site 765952003000 putative ADP binding site [chemical binding]; other site 765952003001 RasGEF domain; Region: RasGEF; pfam00617 765952003002 Ras interaction site [polypeptide binding]; other site 765952003003 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 765952003004 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952003005 pyrophosphate-dependent phosphofructokinase; Region: PLN02251 765952003006 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK07085 765952003007 active site 765952003008 ADP/pyrophosphate binding site [chemical binding]; other site 765952003009 dimerization interface [polypeptide binding]; other site 765952003010 allosteric effector site; other site 765952003011 fructose-1,6-bisphosphate binding site; other site 765952003012 Peptidase family M48; Region: Peptidase_M48; cl12018 765952003013 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 765952003014 NHAD transporter family protein; Provisional; Region: PLN00137 765952003015 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 765952003016 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 765952003017 GDP-Fucose binding site [chemical binding]; other site 765952003018 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952003019 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 765952003020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765952003021 non-specific DNA binding site [nucleotide binding]; other site 765952003022 salt bridge; other site 765952003023 sequence-specific DNA binding site [nucleotide binding]; other site 765952003024 Uncharacterized conserved protein [Function unknown]; Region: COG3189 765952003025 Ubiquitin family; Region: ubiquitin; pfam00240 765952003026 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 765952003027 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003028 active site 765952003029 DNA binding site [nucleotide binding] 765952003030 Int/Topo IB signature motif; other site 765952003031 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952003032 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 765952003033 Pathogenicity locus; Region: Cdd1; pfam11731 765952003034 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 765952003035 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 765952003036 Transposase [DNA replication, recombination, and repair]; Region: COG5433 765952003037 Transposase [DNA replication, recombination, and repair]; Region: COG5433 765952003038 F-box-like; Region: F-box-like; pfam12937 765952003039 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 765952003040 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 765952003041 putative active site [active] 765952003042 putative nucleic acid binding site [nucleotide binding]; other site 765952003043 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 765952003044 NTP binding site [chemical binding]; other site 765952003045 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 765952003046 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 765952003047 SEC-C motif; Region: SEC-C; pfam02810 765952003048 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 765952003049 Ligand Binding Site [chemical binding]; other site 765952003050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952003051 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 765952003052 Walker A motif; other site 765952003053 ATP binding site [chemical binding]; other site 765952003054 Walker B motif; other site 765952003055 arginine finger; other site 765952003056 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 765952003057 Lumazine binding domain; Region: Lum_binding; pfam00677 765952003058 Lumazine binding domain; Region: Lum_binding; pfam00677 765952003059 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 765952003060 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 765952003061 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 765952003062 dimerization interface [polypeptide binding]; other site 765952003063 active site 765952003064 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 765952003065 homopentamer interface [polypeptide binding]; other site 765952003066 active site 765952003067 DoxX; Region: DoxX; pfam07681 765952003068 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952003069 Sel1-like repeats; Region: SEL1; smart00671 765952003070 Sel1-like repeats; Region: SEL1; smart00671 765952003071 Sel1 repeat; Region: Sel1; cl02723 765952003072 Sel1-like repeats; Region: SEL1; smart00671 765952003073 Sel1-like repeats; Region: SEL1; smart00671 765952003074 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759 765952003075 Sel1-like repeats; Region: SEL1; smart00671 765952003076 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952003077 Sel1-like repeats; Region: SEL1; smart00671 765952003078 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952003079 Sel1-like repeats; Region: SEL1; smart00671 765952003080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003081 TPR motif; other site 765952003082 TPR repeat; Region: TPR_11; pfam13414 765952003083 binding surface 765952003084 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 765952003085 FAD binding domain; Region: FAD_binding_4; pfam01565 765952003086 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 765952003087 F-box-like; Region: F-box-like; pfam12937 765952003088 F-box-like; Region: F-box-like; pfam12937 765952003089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003090 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 765952003091 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 765952003092 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 765952003093 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 765952003094 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 765952003095 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 765952003096 RNA binding site [nucleotide binding]; other site 765952003097 Mechanosensitive ion channel; Region: MS_channel; pfam00924 765952003098 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 765952003099 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 765952003100 catalytic residues [active] 765952003101 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 765952003102 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952003103 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952003104 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 765952003105 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 765952003106 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 765952003107 Ligand Binding Site [chemical binding]; other site 765952003108 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 765952003109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003110 FeS/SAM binding site; other site 765952003111 malate dehydrogenase; Provisional; Region: PRK05442 765952003112 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 765952003113 NAD(P) binding site [chemical binding]; other site 765952003114 dimer interface [polypeptide binding]; other site 765952003115 malate binding site [chemical binding]; other site 765952003116 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 765952003117 Citrate synthase; Region: Citrate_synt; pfam00285 765952003118 oxalacetate binding site [chemical binding]; other site 765952003119 citrylCoA binding site [chemical binding]; other site 765952003120 coenzyme A binding site [chemical binding]; other site 765952003121 catalytic triad [active] 765952003122 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 765952003123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952003124 CAAX protease self-immunity; Region: Abi; pfam02517 765952003125 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 765952003126 substrate binding site [chemical binding]; other site 765952003127 acetyl-CoA synthetase; Provisional; Region: PRK00174 765952003128 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 765952003129 active site 765952003130 CoA binding site [chemical binding]; other site 765952003131 acyl-activating enzyme (AAE) consensus motif; other site 765952003132 AMP binding site [chemical binding]; other site 765952003133 acetate binding site [chemical binding]; other site 765952003134 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 765952003135 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 765952003136 catalytic motif [active] 765952003137 Zn binding site [ion binding]; other site 765952003138 RibD C-terminal domain; Region: RibD_C; cl17279 765952003139 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 765952003140 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 765952003141 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952003142 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 765952003143 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 765952003144 putative RNA binding site [nucleotide binding]; other site 765952003145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003146 S-adenosylmethionine binding site [chemical binding]; other site 765952003147 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 765952003148 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 765952003149 dimer interface [polypeptide binding]; other site 765952003150 ADP-ribose binding site [chemical binding]; other site 765952003151 active site 765952003152 nudix motif; other site 765952003153 metal binding site [ion binding]; metal-binding site 765952003154 Protein of unknown function (DUF2937); Region: DUF2937; pfam11157 765952003155 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952003156 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 765952003157 Ligand Binding Site [chemical binding]; other site 765952003158 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 765952003159 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 765952003160 E-class dimer interface [polypeptide binding]; other site 765952003161 P-class dimer interface [polypeptide binding]; other site 765952003162 active site 765952003163 Cu2+ binding site [ion binding]; other site 765952003164 Zn2+ binding site [ion binding]; other site 765952003165 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 765952003166 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 765952003167 nucleotide binding pocket [chemical binding]; other site 765952003168 K-X-D-G motif; other site 765952003169 catalytic site [active] 765952003170 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 765952003171 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 765952003172 Helix-hairpin-helix motif; Region: HHH; pfam00633 765952003173 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 765952003174 Dimer interface [polypeptide binding]; other site 765952003175 BRCT sequence motif; other site 765952003176 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003177 binding surface 765952003178 TPR motif; other site 765952003179 TPR repeat; Region: TPR_11; pfam13414 765952003180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003181 TPR motif; other site 765952003182 binding surface 765952003183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003184 binding surface 765952003185 TPR repeat; Region: TPR_11; pfam13414 765952003186 TPR motif; other site 765952003187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003188 binding surface 765952003189 TPR motif; other site 765952003190 TPR repeat; Region: TPR_11; pfam13414 765952003191 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003192 binding surface 765952003193 TPR motif; other site 765952003194 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 765952003195 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 765952003196 nucleotide binding site [chemical binding]; other site 765952003197 Protein of unknown function (DUF721); Region: DUF721; pfam05258 765952003198 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 765952003199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952003200 ATP binding site [chemical binding]; other site 765952003201 Mg2+ binding site [ion binding]; other site 765952003202 G-X-G motif; other site 765952003203 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 765952003204 anchoring element; other site 765952003205 dimer interface [polypeptide binding]; other site 765952003206 ATP binding site [chemical binding]; other site 765952003207 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 765952003208 active site 765952003209 putative metal-binding site [ion binding]; other site 765952003210 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 765952003211 DNA gyrase subunit A; Validated; Region: PRK05560 765952003212 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 765952003213 CAP-like domain; other site 765952003214 active site 765952003215 primary dimer interface [polypeptide binding]; other site 765952003216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003217 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003218 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003219 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003220 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003221 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 765952003222 thymidylate kinase; Validated; Region: tmk; PRK00698 765952003223 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 765952003224 TMP-binding site; other site 765952003225 ATP-binding site [chemical binding]; other site 765952003226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952003227 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 765952003228 Walker A motif; other site 765952003229 ATP binding site [chemical binding]; other site 765952003230 Walker B motif; other site 765952003231 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 765952003232 arginine finger; other site 765952003233 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 765952003234 Low affinity iron permease; Region: Iron_permease; cl12096 765952003235 Domain of unknown function DUF11; Region: DUF11; cl17728 765952003236 Domain of unknown function DUF11; Region: DUF11; cl17728 765952003237 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 765952003238 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 765952003239 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 765952003240 transaminase; Validated; Region: PRK07324 765952003241 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 765952003242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952003243 homodimer interface [polypeptide binding]; other site 765952003244 catalytic residue [active] 765952003245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 765952003246 YheO-like PAS domain; Region: PAS_6; pfam08348 765952003247 HTH domain; Region: HTH_22; pfam13309 765952003248 putative hydrolase; Provisional; Region: PRK02113 765952003249 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 765952003250 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 765952003251 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 765952003252 HflX GTPase family; Region: HflX; cd01878 765952003253 G1 box; other site 765952003254 GTP/Mg2+ binding site [chemical binding]; other site 765952003255 Switch I region; other site 765952003256 G2 box; other site 765952003257 G3 box; other site 765952003258 Switch II region; other site 765952003259 G4 box; other site 765952003260 G5 box; other site 765952003261 hypothetical protein; Reviewed; Region: PRK00024 765952003262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 765952003263 helix-hairpin-helix signature motif; other site 765952003264 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 765952003265 MPN+ (JAMM) motif; other site 765952003266 Zinc-binding site [ion binding]; other site 765952003267 Protein of unknown function (DUF3638); Region: DUF3638; pfam12340 765952003268 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 765952003269 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 765952003270 catalytic triad [active] 765952003271 amino acid transporter; Region: 2A0306; TIGR00909 765952003272 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952003273 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 765952003274 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952003275 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952003276 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 765952003277 Protein of unknown function (DUF3638); Region: DUF3638; pfam12340 765952003278 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003279 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 765952003280 active site 765952003281 ATP binding site [chemical binding]; other site 765952003282 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 765952003283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952003284 Coenzyme A binding pocket [chemical binding]; other site 765952003285 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 765952003286 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003287 active site 765952003288 DNA binding site [nucleotide binding] 765952003289 Int/Topo IB signature motif; other site 765952003290 Domain of unknown function (DUF927); Region: DUF927; pfam06048 765952003291 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 765952003292 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 765952003293 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 765952003294 active site 765952003295 metal binding site [ion binding]; metal-binding site 765952003296 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 765952003297 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003298 putative active site [active] 765952003299 putative substrate binding site [chemical binding]; other site 765952003300 ATP binding site [chemical binding]; other site 765952003301 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 765952003302 MarR family; Region: MarR; pfam01047 765952003303 hypothetical protein; Provisional; Region: PRK02268 765952003304 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952003305 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 765952003306 putative dimer interface [polypeptide binding]; other site 765952003307 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 765952003308 active site 765952003309 putative catalytic site [active] 765952003310 DNA binding site [nucleotide binding] 765952003311 putative phosphate binding site [ion binding]; other site 765952003312 metal binding site A [ion binding]; metal-binding site 765952003313 AP binding site [nucleotide binding]; other site 765952003314 metal binding site B [ion binding]; metal-binding site 765952003315 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 765952003316 hydrophobic ligand binding site; other site 765952003317 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 765952003318 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 765952003319 FAD binding pocket [chemical binding]; other site 765952003320 conserved FAD binding motif [chemical binding]; other site 765952003321 phosphate binding motif [ion binding]; other site 765952003322 beta-alpha-beta structure motif; other site 765952003323 NAD binding pocket [chemical binding]; other site 765952003324 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952003325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952003326 Cytochrome P450; Region: p450; cl12078 765952003327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003328 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952003329 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 765952003330 putative active site [active] 765952003331 putative metal binding site [ion binding]; other site 765952003332 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952003333 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 765952003334 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003335 putative active site [active] 765952003336 putative substrate binding site [chemical binding]; other site 765952003337 ATP binding site [chemical binding]; other site 765952003338 Tetratricopeptide repeat; Region: TPR_16; pfam13432 765952003339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003340 TPR motif; other site 765952003341 binding surface 765952003342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952003343 TPR motif; other site 765952003344 TPR repeat; Region: TPR_11; pfam13414 765952003345 binding surface 765952003346 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 765952003347 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952003348 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 765952003349 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952003350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003351 S-adenosylmethionine binding site [chemical binding]; other site 765952003352 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 765952003353 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 765952003354 malonyl-CoA binding site [chemical binding]; other site 765952003355 dimer interface [polypeptide binding]; other site 765952003356 active site 765952003357 product binding site; other site 765952003358 Part of AAA domain; Region: AAA_19; pfam13245 765952003359 AAA domain; Region: AAA_11; pfam13086 765952003360 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 765952003361 AAA domain; Region: AAA_30; pfam13604 765952003362 AAA domain; Region: AAA_12; pfam13087 765952003363 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 765952003364 Sulfate transporter family; Region: Sulfate_transp; pfam00916 765952003365 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 765952003366 active site clefts [active] 765952003367 zinc binding site [ion binding]; other site 765952003368 dimer interface [polypeptide binding]; other site 765952003369 magnesium-transporting ATPase; Provisional; Region: PRK15122 765952003370 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 765952003371 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952003372 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 765952003373 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765952003374 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 765952003375 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 765952003376 zinc binding site [ion binding]; other site 765952003377 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 765952003378 classical (c) SDRs; Region: SDR_c; cd05233 765952003379 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 765952003380 NAD(P) binding site [chemical binding]; other site 765952003381 active site 765952003382 TLC ATP/ADP transporter; Region: TLC; cl03940 765952003383 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 765952003384 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003385 active site 765952003386 ATP binding site [chemical binding]; other site 765952003387 substrate binding site [chemical binding]; other site 765952003388 activation loop (A-loop); other site 765952003389 Outer membrane efflux protein; Region: OEP; pfam02321 765952003390 Outer membrane efflux protein; Region: OEP; pfam02321 765952003391 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 765952003392 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 765952003393 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 765952003394 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 765952003395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765952003396 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 765952003397 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 765952003398 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 765952003399 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 765952003400 NADP binding site [chemical binding]; other site 765952003401 dimer interface [polypeptide binding]; other site 765952003402 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 765952003403 MgtC family; Region: MgtC; pfam02308 765952003404 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 765952003405 putative catalytic site [active] 765952003406 putative metal binding site [ion binding]; other site 765952003407 putative phosphate binding site [ion binding]; other site 765952003408 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 765952003409 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 765952003410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 765952003411 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 765952003412 dimer interface [polypeptide binding]; other site 765952003413 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 765952003414 metal binding site [ion binding]; metal-binding site 765952003415 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 765952003416 active site 765952003417 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 765952003418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952003419 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765952003420 Coenzyme A binding pocket [chemical binding]; other site 765952003421 biotin synthase; Region: bioB; TIGR00433 765952003422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003423 FeS/SAM binding site; other site 765952003424 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 765952003425 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 765952003426 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 765952003427 active site 765952003428 metal binding site [ion binding]; metal-binding site 765952003429 DNA binding site [nucleotide binding] 765952003430 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 765952003431 AAA domain; Region: AAA_27; pfam13514 765952003432 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 765952003433 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 765952003434 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 765952003435 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 765952003436 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 765952003437 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 765952003438 Ribosomal protein S6 [Translation, ribosomal structure and biogenesis]; Region: RpsF; COG0360 765952003439 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 765952003440 putative active site [active] 765952003441 catalytic residue [active] 765952003442 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 765952003443 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 765952003444 5S rRNA interface [nucleotide binding]; other site 765952003445 CTC domain interface [polypeptide binding]; other site 765952003446 L16 interface [polypeptide binding]; other site 765952003447 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 765952003448 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 765952003449 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952003450 active site 765952003451 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 765952003452 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 765952003453 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 765952003454 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003455 active site 765952003456 DNA binding site [nucleotide binding] 765952003457 Int/Topo IB signature motif; other site 765952003458 F-box-like; Region: F-box-like; pfam12937 765952003459 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 765952003460 TraU protein; Region: TraU; pfam06834 765952003461 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 765952003462 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 765952003463 F plasmid transfer operon protein; Region: TraF; pfam13728 765952003464 Fic/DOC family; Region: Fic; cl00960 765952003465 Antitoxin ParD; Region: ParD; pfam09386 765952003466 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952003467 metal binding site [ion binding]; metal-binding site 765952003468 Archaeal ATPase; Region: Arch_ATPase; pfam01637 765952003469 AAA ATPase domain; Region: AAA_16; pfam13191 765952003470 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 765952003471 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 765952003472 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 765952003473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003474 S-adenosylmethionine binding site [chemical binding]; other site 765952003475 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765952003476 MgtE intracellular N domain; Region: MgtE_N; pfam03448 765952003477 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765952003478 Divalent cation transporter; Region: MgtE; pfam01769 765952003479 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 765952003480 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 765952003481 G1 box; other site 765952003482 putative GEF interaction site [polypeptide binding]; other site 765952003483 GTP/Mg2+ binding site [chemical binding]; other site 765952003484 Switch I region; other site 765952003485 G2 box; other site 765952003486 G3 box; other site 765952003487 Switch II region; other site 765952003488 G4 box; other site 765952003489 G5 box; other site 765952003490 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 765952003491 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 765952003492 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003493 active site 765952003494 ATP binding site [chemical binding]; other site 765952003495 substrate binding site [chemical binding]; other site 765952003496 activation loop (A-loop); other site 765952003497 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 765952003498 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 765952003499 active site 765952003500 ATP binding site [chemical binding]; other site 765952003501 substrate binding site [chemical binding]; other site 765952003502 activation loop (A-loop); other site 765952003503 F-box-like; Region: F-box-like; pfam12937 765952003504 FOG: WD40 repeat [General function prediction only]; Region: COG2319 765952003505 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952003506 structural tetrad; other site 765952003507 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 765952003508 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 765952003509 Ligand binding site; other site 765952003510 oligomer interface; other site 765952003511 CTP synthetase; Validated; Region: pyrG; PRK05380 765952003512 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 765952003513 active site 765952003514 UTP binding site [chemical binding]; other site 765952003515 Catalytic site [active] 765952003516 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 765952003517 active site 765952003518 putative oxyanion hole; other site 765952003519 catalytic triad [active] 765952003520 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 765952003521 EVE domain; Region: EVE; cl00728 765952003522 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 765952003523 homotrimer interaction site [polypeptide binding]; other site 765952003524 putative active site [active] 765952003525 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 765952003526 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 765952003527 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 765952003528 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 765952003529 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 765952003530 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 765952003531 putative active site [active] 765952003532 coproporphyrinogen III oxidase; Provisional; Region: PRK06294 765952003533 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003534 FeS/SAM binding site; other site 765952003535 HemN C-terminal domain; Region: HemN_C; pfam06969 765952003536 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 765952003537 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 765952003538 homodimer interface [polypeptide binding]; other site 765952003539 putative SAM binding site [chemical binding]; other site 765952003540 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 765952003541 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 765952003542 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 765952003543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952003544 motif II; other site 765952003545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952003546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952003547 Coenzyme A binding pocket [chemical binding]; other site 765952003548 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 765952003549 NeuB family; Region: NeuB; pfam03102 765952003550 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 765952003551 NeuB binding interface [polypeptide binding]; other site 765952003552 putative substrate binding site [chemical binding]; other site 765952003553 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 765952003554 ligand binding site; other site 765952003555 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 765952003556 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 765952003557 active site 765952003558 DNA binding site [nucleotide binding] 765952003559 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 765952003560 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 765952003561 dimer interface [polypeptide binding]; other site 765952003562 ssDNA binding site [nucleotide binding]; other site 765952003563 tetramer (dimer of dimers) interface [polypeptide binding]; other site 765952003564 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 765952003565 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 765952003566 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 765952003567 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 765952003568 active site 765952003569 catalytic site [active] 765952003570 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 765952003571 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 765952003572 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 765952003573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952003574 Walker A motif; other site 765952003575 ATP binding site [chemical binding]; other site 765952003576 Walker B motif; other site 765952003577 arginine finger; other site 765952003578 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 765952003579 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 765952003580 Na2 binding site [ion binding]; other site 765952003581 putative substrate binding site 1 [chemical binding]; other site 765952003582 Na binding site 1 [ion binding]; other site 765952003583 putative substrate binding site 2 [chemical binding]; other site 765952003584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003585 S-adenosylmethionine binding site [chemical binding]; other site 765952003586 Transmembrane proteins 14C; Region: Tmemb_14; pfam03647 765952003587 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 765952003588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 765952003589 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 765952003590 heme-binding site [chemical binding]; other site 765952003591 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 765952003592 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 765952003593 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003594 FeS/SAM binding site; other site 765952003595 glycogen branching enzyme; Provisional; Region: PRK05402 765952003596 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 765952003597 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 765952003598 active site 765952003599 catalytic site [active] 765952003600 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 765952003601 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 765952003602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 765952003603 ATP binding site [chemical binding]; other site 765952003604 Mg++ binding site [ion binding]; other site 765952003605 motif III; other site 765952003606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 765952003607 nucleotide binding region [chemical binding]; other site 765952003608 ATP-binding site [chemical binding]; other site 765952003609 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952003610 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 765952003611 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 765952003612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 765952003613 AlkA N-terminal domain; Region: AlkA_N; pfam06029 765952003614 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 765952003615 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765952003616 minor groove reading motif; other site 765952003617 helix-hairpin-helix signature motif; other site 765952003618 substrate binding pocket [chemical binding]; other site 765952003619 active site 765952003620 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 765952003621 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 765952003622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952003623 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 765952003624 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003625 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 765952003626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952003627 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 765952003628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952003629 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952003630 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 765952003631 iron-sulfur cluster [ion binding]; other site 765952003632 [2Fe-2S] cluster binding site [ion binding]; other site 765952003633 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 765952003634 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 765952003635 30S subunit binding site; other site 765952003636 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 765952003637 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 765952003638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952003639 FeS/SAM binding site; other site 765952003640 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 765952003641 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 765952003642 dimer interface [polypeptide binding]; other site 765952003643 putative anticodon binding site; other site 765952003644 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765952003645 motif 1; other site 765952003646 dimer interface [polypeptide binding]; other site 765952003647 active site 765952003648 motif 2; other site 765952003649 motif 3; other site 765952003650 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952003653 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 765952003654 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 765952003655 4Fe-4S binding domain; Region: Fer4; pfam00037 765952003656 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 765952003657 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 765952003658 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952003659 active site 765952003660 HIGH motif; other site 765952003661 nucleotide binding site [chemical binding]; other site 765952003662 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 765952003663 KMSKS motif; other site 765952003664 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765952003665 tRNA binding surface [nucleotide binding]; other site 765952003666 anticodon binding site; other site 765952003667 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 765952003668 putative acyl-acceptor binding pocket; other site 765952003669 long chain fatty acid--[acyl-carrier-protein] ligase; Validated; Region: PRK06334 765952003670 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 765952003671 acyl-activating enzyme (AAE) consensus motif; other site 765952003672 AMP binding site [chemical binding]; other site 765952003673 active site 765952003674 CoA binding site [chemical binding]; other site 765952003675 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 765952003676 active site residue [active] 765952003677 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 765952003678 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 765952003679 putative active site [active] 765952003680 PhoH-like protein; Region: PhoH; pfam02562 765952003681 Bacterial SH3 domain homologues; Region: SH3b; smart00287 765952003682 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 765952003683 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 765952003684 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 765952003685 active site 765952003686 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 765952003687 LexA repressor; Validated; Region: PRK00215 765952003688 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 765952003689 Catalytic site [active] 765952003690 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 765952003691 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 765952003692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952003693 Walker A/P-loop; other site 765952003694 ATP binding site [chemical binding]; other site 765952003695 Q-loop/lid; other site 765952003696 ABC transporter signature motif; other site 765952003697 Walker B; other site 765952003698 D-loop; other site 765952003699 H-loop/switch region; other site 765952003700 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 765952003701 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 765952003702 active site 765952003703 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765952003704 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952003705 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 765952003706 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 765952003707 nucleotide binding site [chemical binding]; other site 765952003708 putative NEF/HSP70 interaction site [polypeptide binding]; other site 765952003709 SBD interface [polypeptide binding]; other site 765952003710 NIMA-related protein kinase; Provisional; Region: PTZ00266 765952003711 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 765952003712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952003713 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 765952003714 CheW-like domain; Region: CheW; pfam01584 765952003715 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952003716 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 765952003717 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952003718 dimer interface [polypeptide binding]; other site 765952003719 putative CheW interface [polypeptide binding]; other site 765952003720 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 765952003721 putative binding surface; other site 765952003722 active site 765952003723 conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193 765952003724 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952003725 ATP binding site [chemical binding]; other site 765952003726 Mg2+ binding site [ion binding]; other site 765952003727 G-X-G motif; other site 765952003728 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 765952003729 Response regulator receiver domain; Region: Response_reg; pfam00072 765952003730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952003731 active site 765952003732 phosphorylation site [posttranslational modification] 765952003733 intermolecular recognition site; other site 765952003734 dimerization interface [polypeptide binding]; other site 765952003735 Response regulator receiver domain; Region: Response_reg; pfam00072 765952003736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952003737 active site 765952003738 phosphorylation site [posttranslational modification] 765952003739 intermolecular recognition site; other site 765952003740 dimerization interface [polypeptide binding]; other site 765952003741 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 765952003742 cyclase homology domain; Region: CHD; cd07302 765952003743 nucleotidyl binding site; other site 765952003744 metal binding site [ion binding]; metal-binding site 765952003745 dimer interface [polypeptide binding]; other site 765952003746 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952003747 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952003748 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952003749 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952003750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765952003751 Walker A/P-loop; other site 765952003752 ATP binding site [chemical binding]; other site 765952003753 Q-loop/lid; other site 765952003754 ABC transporter signature motif; other site 765952003755 Walker B; other site 765952003756 D-loop; other site 765952003757 H-loop/switch region; other site 765952003758 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765952003759 DevC protein; Region: devC; TIGR01185 765952003760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 765952003761 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 765952003762 ligand binding site [chemical binding]; other site 765952003763 CAAX protease self-immunity; Region: Abi; pfam02517 765952003764 Superoxide dismutase [Fe]; Provisional; Region: PTZ00078 765952003765 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 765952003766 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 765952003767 hypothetical protein; Provisional; Region: PRK06489 765952003768 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 765952003769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952003770 motif II; other site 765952003771 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 765952003772 GIY-YIG motif/motif A; other site 765952003773 putative active site [active] 765952003774 putative metal binding site [ion binding]; other site 765952003775 RF-1 domain; Region: RF-1; pfam00472 765952003776 Flagellin N-methylase; Region: FliB; pfam03692 765952003777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 765952003778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 765952003779 DNA binding residues [nucleotide binding] 765952003780 dimerization interface [polypeptide binding]; other site 765952003781 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 765952003782 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 765952003783 dimer interface [polypeptide binding]; other site 765952003784 [2Fe-2S] cluster binding site [ion binding]; other site 765952003785 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952003786 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765952003787 active site 765952003788 catalytic tetrad [active] 765952003789 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 765952003790 homodimer interaction site [polypeptide binding]; other site 765952003791 cofactor binding site; other site 765952003792 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 765952003793 catalytic core [active] 765952003794 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 765952003795 nudix motif; other site 765952003796 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_19; cd04678 765952003797 nudix motif; other site 765952003798 NmrA-like family; Region: NmrA; pfam05368 765952003799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003800 NAD(P) binding site [chemical binding]; other site 765952003801 active site 765952003802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 765952003803 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 765952003804 P-loop motif; other site 765952003805 ATP binding site [chemical binding]; other site 765952003806 Chloramphenicol (Cm) binding site [chemical binding]; other site 765952003807 catalytic residue [active] 765952003808 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 765952003809 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 765952003810 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 765952003811 putative active site [active] 765952003812 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 765952003813 CsbD-like; Region: CsbD; cl17424 765952003814 BON domain; Region: BON; pfam04972 765952003815 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003816 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 765952003817 active site 765952003818 ATP binding site [chemical binding]; other site 765952003819 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952003820 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 765952003821 Yqey-like protein; Region: YqeY; cl17540 765952003822 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 765952003823 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 765952003824 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 765952003825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765952003826 Walker A/P-loop; other site 765952003827 ATP binding site [chemical binding]; other site 765952003828 Q-loop/lid; other site 765952003829 ABC transporter signature motif; other site 765952003830 Walker B; other site 765952003831 D-loop; other site 765952003832 H-loop/switch region; other site 765952003833 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 765952003834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 765952003835 Walker A/P-loop; other site 765952003836 ATP binding site [chemical binding]; other site 765952003837 Q-loop/lid; other site 765952003838 ABC transporter signature motif; other site 765952003839 Walker B; other site 765952003840 D-loop; other site 765952003841 H-loop/switch region; other site 765952003842 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 765952003843 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 765952003844 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 765952003845 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952003846 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952003847 Outer membrane efflux protein; Region: OEP; pfam02321 765952003848 Outer membrane efflux protein; Region: OEP; pfam02321 765952003849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952003850 NADH(P)-binding; Region: NAD_binding_10; pfam13460 765952003851 NAD(P) binding site [chemical binding]; other site 765952003852 active site 765952003853 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952003854 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 765952003855 putative NAD(P) binding site [chemical binding]; other site 765952003856 putative substrate binding site [chemical binding]; other site 765952003857 catalytic Zn binding site [ion binding]; other site 765952003858 structural Zn binding site [ion binding]; other site 765952003859 dimer interface [polypeptide binding]; other site 765952003860 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 765952003861 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 765952003862 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 765952003863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952003864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765952003865 active site 765952003866 catalytic tetrad [active] 765952003867 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765952003868 Coenzyme A binding pocket [chemical binding]; other site 765952003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952003870 S-adenosylmethionine binding site [chemical binding]; other site 765952003871 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 765952003872 Phosphotransferase enzyme family; Region: APH; pfam01636 765952003873 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 765952003874 active site 765952003875 substrate binding site [chemical binding]; other site 765952003876 ATP binding site [chemical binding]; other site 765952003877 AAA domain; Region: AAA_17; pfam13207 765952003878 AAA domain; Region: AAA_18; pfam13238 765952003879 Domain of unknown function (DUF3328); Region: DUF3328; pfam11807 765952003880 TMPIT-like protein; Region: TMPIT; pfam07851 765952003881 SpoVG; Region: SpoVG; cl00915 765952003882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 765952003883 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 765952003884 active site 765952003885 metal binding site [ion binding]; metal-binding site 765952003886 interdomain interaction site; other site 765952003887 D5 N terminal like; Region: D5_N; smart00885 765952003888 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 765952003889 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 765952003890 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 765952003891 catalytic nucleophile [active] 765952003892 Recombinase; Region: Recombinase; pfam07508 765952003893 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 765952003894 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 765952003895 PLD-like domain; Region: PLDc_2; pfam13091 765952003896 putative active site [active] 765952003897 catalytic site [active] 765952003898 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 765952003899 PLD-like domain; Region: PLDc_2; pfam13091 765952003900 putative active site [active] 765952003901 catalytic site [active] 765952003902 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 765952003903 AAA domain; Region: AAA_30; pfam13604 765952003904 Family description; Region: UvrD_C_2; pfam13538 765952003905 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 765952003906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952003907 putative substrate translocation pore; other site 765952003908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 765952003909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 765952003910 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 765952003911 putative effector binding pocket; other site 765952003912 dimerization interface [polypeptide binding]; other site 765952003913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 765952003914 putative DNA binding site [nucleotide binding]; other site 765952003915 putative Zn2+ binding site [ion binding]; other site 765952003916 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 765952003917 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 765952003918 Vitamin K epoxide reductase (VKOR) family in bacteria; Region: VKOR_4; cd12921 765952003919 putative active site [active] 765952003920 redox center [active] 765952003921 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 765952003922 catalytic residues [active] 765952003923 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952003924 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765952003925 Walker A/P-loop; other site 765952003926 ATP binding site [chemical binding]; other site 765952003927 Q-loop/lid; other site 765952003928 ABC transporter signature motif; other site 765952003929 Walker B; other site 765952003930 D-loop; other site 765952003931 H-loop/switch region; other site 765952003932 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 765952003933 FtsX-like permease family; Region: FtsX; pfam02687 765952003934 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 765952003935 UGMP family protein; Validated; Region: PRK09604 765952003936 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 765952003937 MarC family integral membrane protein; Region: MarC; pfam01914 765952003938 MarC family integral membrane protein; Region: MarC; cl00919 765952003939 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 765952003940 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 765952003941 dimerization interface 3.5A [polypeptide binding]; other site 765952003942 active site 765952003943 Domain of unknown function (DUF368); Region: DUF368; pfam04018 765952003944 SasC/Mrp/FmtB intercellular aggregation domain; Region: SasC_Mrp_aggreg; TIGR04263 765952003945 Domain of unknown function (DUF368); Region: DUF368; pfam04018 765952003946 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 765952003947 Helix-turn-helix domain; Region: HTH_25; pfam13413 765952003948 non-specific DNA binding site [nucleotide binding]; other site 765952003949 salt bridge; other site 765952003950 sequence-specific DNA binding site [nucleotide binding]; other site 765952003951 ribonuclease HIII; Provisional; Region: PRK00996 765952003952 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 765952003953 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 765952003954 RNA/DNA hybrid binding site [nucleotide binding]; other site 765952003955 active site 765952003956 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 765952003957 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 765952003958 Walker A/P-loop; other site 765952003959 ATP binding site [chemical binding]; other site 765952003960 Q-loop/lid; other site 765952003961 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 765952003962 Q-loop/lid; other site 765952003963 ABC transporter signature motif; other site 765952003964 Walker B; other site 765952003965 D-loop; other site 765952003966 H-loop/switch region; other site 765952003967 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 765952003968 glucose-1-dehydrogenase; Provisional; Region: PRK06947 765952003969 NADP binding site [chemical binding]; other site 765952003970 substrate binding site [chemical binding]; other site 765952003971 active site 765952003972 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 765952003973 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952003974 active site 765952003975 catalytic tetrad [active] 765952003976 Outer membrane efflux protein; Region: OEP; pfam02321 765952003977 Outer membrane efflux protein; Region: OEP; pfam02321 765952003978 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 765952003979 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952003980 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 765952003981 MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...; Region: MBD; cl00110 765952003982 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 765952003983 dimer interface [polypeptide binding]; other site 765952003984 ADP-ribose binding site [chemical binding]; other site 765952003985 active site 765952003986 nudix motif; other site 765952003987 metal binding site [ion binding]; metal-binding site 765952003988 integrase; Provisional; Region: int; PHA02601 765952003989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952003990 active site 765952003991 DNA binding site [nucleotide binding] 765952003992 Int/Topo IB signature motif; other site 765952003993 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 765952003994 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 765952003995 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 765952003996 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952003997 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765952003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 765952003999 Methyltransferase domain; Region: Methyltransf_31; pfam13847 765952004000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004001 S-adenosylmethionine binding site [chemical binding]; other site 765952004002 TIGR01777 family protein; Region: yfcH 765952004003 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 765952004004 putative NAD(P) binding site [chemical binding]; other site 765952004005 putative active site [active] 765952004006 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 765952004007 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765952004008 putative catalytic residue [active] 765952004009 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 765952004010 Sel1-like repeats; Region: SEL1; smart00671 765952004011 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 765952004012 DNA photolyase; Region: DNA_photolyase; pfam00875 765952004013 methionine aminopeptidase; Provisional; Region: PRK12318 765952004014 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 765952004015 active site 765952004016 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 765952004017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952004018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952004019 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952004020 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 765952004021 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 765952004022 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 765952004023 active site 765952004024 HIGH motif; other site 765952004025 KMSKS motif; other site 765952004026 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 765952004027 tRNA binding surface [nucleotide binding]; other site 765952004028 anticodon binding site; other site 765952004029 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 765952004030 dimer interface [polypeptide binding]; other site 765952004031 putative tRNA-binding site [nucleotide binding]; other site 765952004032 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 765952004033 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 765952004034 catalytic site [active] 765952004035 G-X2-G-X-G-K; other site 765952004036 hypothetical protein; Provisional; Region: PRK11820 765952004037 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 765952004038 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 765952004039 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 765952004040 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 765952004041 dimer interface [polypeptide binding]; other site 765952004042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952004043 catalytic residue [active] 765952004044 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 765952004045 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 765952004046 homodimer interface [polypeptide binding]; other site 765952004047 substrate-cofactor binding pocket; other site 765952004048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952004049 catalytic residue [active] 765952004050 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 765952004051 Predicted flavoprotein [General function prediction only]; Region: COG0431 765952004052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 765952004053 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 765952004054 Divalent cation transporter; Region: MgtE; cl00786 765952004055 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 765952004056 RNA/DNA hybrid binding site [nucleotide binding]; other site 765952004057 active site 765952004058 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 765952004059 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 765952004060 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 765952004061 signal recognition particle protein; Provisional; Region: PRK10867 765952004062 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 765952004063 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765952004064 P loop; other site 765952004065 GTP binding site [chemical binding]; other site 765952004066 Signal peptide binding domain; Region: SRP_SPB; pfam02978 765952004067 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 765952004068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004069 S-adenosylmethionine binding site [chemical binding]; other site 765952004070 peptide chain release factor 1; Validated; Region: prfA; PRK00591 765952004071 PCRF domain; Region: PCRF; pfam03462 765952004072 RF-1 domain; Region: RF-1; pfam00472 765952004073 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 765952004074 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 765952004075 active site 765952004076 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952004077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952004078 MORN repeat; Region: MORN; cl14787 765952004079 Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases; Region: MORN; smart00698 765952004080 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 765952004081 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 765952004082 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 765952004083 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765952004084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765952004085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765952004086 Protein phosphatase 2C; Region: PP2C; pfam00481 765952004087 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 765952004088 active site 765952004089 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 765952004090 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 765952004091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 765952004092 catalytic residue [active] 765952004093 glycogen synthase; Provisional; Region: glgA; PRK00654 765952004094 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 765952004095 ADP-binding pocket [chemical binding]; other site 765952004096 homodimer interface [polypeptide binding]; other site 765952004097 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 765952004098 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 765952004099 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 765952004100 substrate binding site [chemical binding]; other site 765952004101 ATP binding site [chemical binding]; other site 765952004102 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952004103 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952004104 DTW domain; Region: DTW; cl01221 765952004105 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 765952004106 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765952004107 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 765952004108 Part of AAA domain; Region: AAA_19; pfam13245 765952004109 Family description; Region: UvrD_C_2; pfam13538 765952004110 Ribonuclease P; Region: Ribonuclease_P; pfam00825 765952004111 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 765952004112 putative active site [active] 765952004113 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 765952004114 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 765952004115 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 765952004116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 765952004117 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 765952004118 BON domain; Region: BON; pfam04972 765952004119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 765952004120 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 765952004121 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765952004122 active site 765952004123 catalytic site [active] 765952004124 substrate binding site [chemical binding]; other site 765952004125 Maf-like protein; Region: Maf; pfam02545 765952004126 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 765952004127 active site 765952004128 dimer interface [polypeptide binding]; other site 765952004129 HEAT repeats; Region: HEAT_2; pfam13646 765952004130 HEAT repeats; Region: HEAT_2; pfam13646 765952004131 Organic solvent tolerance protein; Region: OstA_C; pfam04453 765952004132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952004133 Coenzyme A binding pocket [chemical binding]; other site 765952004134 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 765952004135 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 765952004136 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 765952004137 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 765952004138 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 765952004139 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 765952004140 substrate binding pocket [chemical binding]; other site 765952004141 chain length determination region; other site 765952004142 substrate-Mg2+ binding site; other site 765952004143 catalytic residues [active] 765952004144 aspartate-rich region 1; other site 765952004145 active site lid residues [active] 765952004146 aspartate-rich region 2; other site 765952004147 Bacterial sugar transferase; Region: Bac_transf; pfam02397 765952004148 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 765952004149 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 765952004150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952004151 catalytic residue [active] 765952004152 Domain of unknown function (DUF202); Region: DUF202; cl09954 765952004153 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 765952004154 Uncharacterized conserved protein [Function unknown]; Region: COG1284 765952004155 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 765952004156 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 765952004157 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 765952004158 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 765952004159 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 765952004160 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 765952004161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 765952004162 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 765952004163 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 765952004164 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 765952004165 carboxyltransferase (CT) interaction site; other site 765952004166 biotinylation site [posttranslational modification]; other site 765952004167 elongation factor P; Provisional; Region: PRK12426 765952004168 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 765952004169 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 765952004170 RNA binding site [nucleotide binding]; other site 765952004171 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 765952004172 RNA binding site [nucleotide binding]; other site 765952004173 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 765952004174 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 765952004175 substrate binding site [chemical binding]; other site 765952004176 hexamer interface [polypeptide binding]; other site 765952004177 metal binding site [ion binding]; metal-binding site 765952004178 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 765952004179 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 765952004180 putative catalytic residues [active] 765952004181 putative nucleotide binding site [chemical binding]; other site 765952004182 putative aspartate binding site [chemical binding]; other site 765952004183 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 765952004184 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 765952004185 active site 765952004186 Riboflavin kinase; Region: Flavokinase; smart00904 765952004187 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00989 765952004188 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 765952004189 RNA binding site [nucleotide binding]; other site 765952004190 active site 765952004191 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 765952004192 translation initiation factor IF-2; Region: IF-2; TIGR00487 765952004193 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 765952004194 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 765952004195 G1 box; other site 765952004196 putative GEF interaction site [polypeptide binding]; other site 765952004197 GTP/Mg2+ binding site [chemical binding]; other site 765952004198 Switch I region; other site 765952004199 G2 box; other site 765952004200 G3 box; other site 765952004201 Switch II region; other site 765952004202 G4 box; other site 765952004203 G5 box; other site 765952004204 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 765952004205 Translation-initiation factor 2; Region: IF-2; pfam11987 765952004206 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 765952004207 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 765952004208 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 765952004209 NusA N-terminal domain; Region: NusA_N; pfam08529 765952004210 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 765952004211 RNA binding site [nucleotide binding]; other site 765952004212 homodimer interface [polypeptide binding]; other site 765952004213 NusA-like KH domain; Region: KH_5; pfam13184 765952004214 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 765952004215 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 765952004216 RNA binding site [nucleotide binding]; other site 765952004217 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 765952004218 RNA binding site [nucleotide binding]; other site 765952004219 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952004220 RNA binding site [nucleotide binding]; other site 765952004221 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 765952004222 RNA binding site [nucleotide binding]; other site 765952004223 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 765952004224 RNA binding site [nucleotide binding]; other site 765952004225 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 765952004226 RNA binding site [nucleotide binding]; other site 765952004227 domain interface; other site 765952004228 MraW methylase family; Region: Methyltransf_5; cl17771 765952004229 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 765952004230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004231 TPR motif; other site 765952004232 binding surface 765952004233 Tetratricopeptide repeat; Region: TPR_9; pfam13371 765952004234 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 765952004235 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 765952004236 inhibitor-cofactor binding pocket; inhibition site 765952004237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 765952004238 catalytic residue [active] 765952004239 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952004240 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952004241 dimer interface [polypeptide binding]; other site 765952004242 putative CheW interface [polypeptide binding]; other site 765952004243 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 765952004244 dimerization interface [polypeptide binding]; other site 765952004245 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952004246 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952004247 dimer interface [polypeptide binding]; other site 765952004248 putative CheW interface [polypeptide binding]; other site 765952004249 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 765952004250 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 765952004251 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 765952004252 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 765952004253 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952004254 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952004255 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 765952004256 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 765952004257 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 765952004258 active site 765952004259 metal binding site [ion binding]; metal-binding site 765952004260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004261 binding surface 765952004262 TPR repeat; Region: TPR_11; pfam13414 765952004263 TPR motif; other site 765952004264 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 765952004265 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 765952004266 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 765952004267 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 765952004268 Clp amino terminal domain; Region: Clp_N; pfam02861 765952004269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004270 Walker A motif; other site 765952004271 ATP binding site [chemical binding]; other site 765952004272 Walker B motif; other site 765952004273 arginine finger; other site 765952004274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004275 Walker A motif; other site 765952004276 ATP binding site [chemical binding]; other site 765952004277 Walker B motif; other site 765952004278 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 765952004279 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 765952004280 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 765952004281 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 765952004282 Response regulator receiver domain; Region: Response_reg; pfam00072 765952004283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952004284 active site 765952004285 phosphorylation site [posttranslational modification] 765952004286 intermolecular recognition site; other site 765952004287 dimerization interface [polypeptide binding]; other site 765952004288 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 765952004289 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 765952004290 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 765952004291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952004292 active site 765952004293 phosphorylation site [posttranslational modification] 765952004294 intermolecular recognition site; other site 765952004295 CheB methylesterase; Region: CheB_methylest; pfam01339 765952004296 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 765952004297 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 765952004298 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 765952004299 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 765952004300 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 765952004301 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 765952004302 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 765952004303 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 765952004304 DNA binding site [nucleotide binding] 765952004305 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 765952004306 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 765952004307 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 765952004308 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 765952004309 DNA-directed RNA polymerase, beta subunit; Region: rpoB; TIGR02013 765952004310 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765952004311 RPB11 interaction site [polypeptide binding]; other site 765952004312 RPB12 interaction site [polypeptide binding]; other site 765952004313 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 765952004314 RPB3 interaction site [polypeptide binding]; other site 765952004315 RPB1 interaction site [polypeptide binding]; other site 765952004316 RPB11 interaction site [polypeptide binding]; other site 765952004317 RPB10 interaction site [polypeptide binding]; other site 765952004318 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 765952004319 peripheral dimer interface [polypeptide binding]; other site 765952004320 core dimer interface [polypeptide binding]; other site 765952004321 L10 interface [polypeptide binding]; other site 765952004322 L11 interface [polypeptide binding]; other site 765952004323 putative EF-Tu interaction site [polypeptide binding]; other site 765952004324 putative EF-G interaction site [polypeptide binding]; other site 765952004325 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 765952004326 23S rRNA interface [nucleotide binding]; other site 765952004327 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 765952004328 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 765952004329 mRNA/rRNA interface [nucleotide binding]; other site 765952004330 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 765952004331 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 765952004332 23S rRNA interface [nucleotide binding]; other site 765952004333 L7/L12 interface [polypeptide binding]; other site 765952004334 putative thiostrepton binding site; other site 765952004335 L25 interface [polypeptide binding]; other site 765952004336 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 765952004337 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 765952004338 putative homodimer interface [polypeptide binding]; other site 765952004339 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 765952004340 heterodimer interface [polypeptide binding]; other site 765952004341 homodimer interface [polypeptide binding]; other site 765952004342 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 765952004343 elongation factor Tu; Reviewed; Region: PRK12735 765952004344 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 765952004345 G1 box; other site 765952004346 GEF interaction site [polypeptide binding]; other site 765952004347 GTP/Mg2+ binding site [chemical binding]; other site 765952004348 Switch I region; other site 765952004349 G2 box; other site 765952004350 G3 box; other site 765952004351 Switch II region; other site 765952004352 G4 box; other site 765952004353 G5 box; other site 765952004354 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 765952004355 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 765952004356 Antibiotic Binding Site [chemical binding]; other site 765952004357 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 765952004358 rRNA binding site [nucleotide binding]; other site 765952004359 predicted 30S ribosome binding site; other site 765952004360 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 765952004361 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952004362 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 765952004363 putative NAD(P) binding site [chemical binding]; other site 765952004364 putative substrate binding site [chemical binding]; other site 765952004365 catalytic Zn binding site [ion binding]; other site 765952004366 structural Zn binding site [ion binding]; other site 765952004367 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 765952004368 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 765952004369 E3 interaction surface; other site 765952004370 lipoyl attachment site [posttranslational modification]; other site 765952004371 e3 binding domain; Region: E3_binding; pfam02817 765952004372 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 765952004373 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 765952004374 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 765952004375 alpha subunit interface [polypeptide binding]; other site 765952004376 TPP binding site [chemical binding]; other site 765952004377 heterodimer interface [polypeptide binding]; other site 765952004378 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 765952004379 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 765952004380 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 765952004381 tetramer interface [polypeptide binding]; other site 765952004382 TPP-binding site [chemical binding]; other site 765952004383 heterodimer interface [polypeptide binding]; other site 765952004384 phosphorylation loop region [posttranslational modification] 765952004385 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765952004386 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 765952004387 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 765952004388 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 765952004389 active site 765952004390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 765952004391 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765952004392 catalytic residue [active] 765952004393 Chitin synthesis regulation, resistance to Congo red; Region: RCR; pfam12273 765952004394 hypothetical protein; Provisional; Region: PRK13665 765952004395 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 765952004396 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 765952004397 dimer interface [polypeptide binding]; other site 765952004398 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 765952004399 active site residues [active] 765952004400 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 765952004401 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 765952004402 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 765952004403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004404 binding surface 765952004405 TPR motif; other site 765952004406 recombination protein F; Reviewed; Region: recF; PRK00064 765952004407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952004408 Walker A/P-loop; other site 765952004409 ATP binding site [chemical binding]; other site 765952004410 Q-loop/lid; other site 765952004411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952004412 ABC transporter signature motif; other site 765952004413 Walker B; other site 765952004414 D-loop; other site 765952004415 H-loop/switch region; other site 765952004416 DNA polymerase III subunit beta; Validated; Region: PRK05643 765952004417 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 765952004418 putative DNA binding surface [nucleotide binding]; other site 765952004419 dimer interface [polypeptide binding]; other site 765952004420 beta-clamp/clamp loader binding surface; other site 765952004421 beta-clamp/translesion DNA polymerase binding surface; other site 765952004422 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 765952004423 SmpB-tmRNA interface; other site 765952004424 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 765952004425 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 765952004426 putative active site [active] 765952004427 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 765952004428 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 765952004429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765952004430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952004431 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 765952004432 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 765952004433 Na binding site [ion binding]; other site 765952004434 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 765952004435 UbiA prenyltransferase family; Region: UbiA; pfam01040 765952004436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952004437 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 765952004438 substrate binding site [chemical binding]; other site 765952004439 oxyanion hole (OAH) forming residues; other site 765952004440 trimer interface [polypeptide binding]; other site 765952004441 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 765952004442 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 765952004443 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 765952004444 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 765952004445 dimer interface [polypeptide binding]; other site 765952004446 tetramer interface [polypeptide binding]; other site 765952004447 PYR/PP interface [polypeptide binding]; other site 765952004448 TPP binding site [chemical binding]; other site 765952004449 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 765952004450 TPP-binding site [chemical binding]; other site 765952004451 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 765952004452 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 765952004453 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 765952004454 TRAM domain; Region: TRAM; pfam01938 765952004455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004456 S-adenosylmethionine binding site [chemical binding]; other site 765952004457 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 765952004458 propionate/acetate kinase; Provisional; Region: PRK12379 765952004459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004460 S-adenosylmethionine binding site [chemical binding]; other site 765952004461 Hemerythrin-like domain; Region: Hr-like; cd12108 765952004462 Fe binding site [ion binding]; other site 765952004463 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 765952004464 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 765952004465 conserved cys residue [active] 765952004466 Uncharacterized conserved protein [Function unknown]; Region: COG1262 765952004467 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 765952004468 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 765952004469 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765952004470 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765952004471 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 765952004472 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 765952004473 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765952004474 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 765952004475 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 765952004476 Uncharacterized protein conserved in bacteria [General function prediction only]; Region: OraA; COG2137 765952004477 DNA topoisomerase IV subunit A; Provisional; Region: PRK09631 765952004478 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 765952004479 CAP-like domain; other site 765952004480 active site 765952004481 primary dimer interface [polypeptide binding]; other site 765952004482 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 765952004483 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 765952004484 ATP binding site [chemical binding]; other site 765952004485 Mg2+ binding site [ion binding]; other site 765952004486 G-X-G motif; other site 765952004487 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 765952004488 anchoring element; other site 765952004489 dimer interface [polypeptide binding]; other site 765952004490 ATP binding site [chemical binding]; other site 765952004491 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 765952004492 active site 765952004493 putative metal-binding site [ion binding]; other site 765952004494 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 765952004495 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 765952004496 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 765952004497 NAD(P) binding site [chemical binding]; other site 765952004498 homodimer interface [polypeptide binding]; other site 765952004499 substrate binding site [chemical binding]; other site 765952004500 active site 765952004501 BNR repeat-like domain; Region: BNR_2; pfam13088 765952004502 glutamyl-tRNA reductase; Validated; Region: hemA; PRK00676 765952004503 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 765952004504 tRNA; other site 765952004505 putative tRNA binding site [nucleotide binding]; other site 765952004506 putative NADP binding site [chemical binding]; other site 765952004507 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 765952004508 MutS domain I; Region: MutS_I; pfam01624 765952004509 MutS domain II; Region: MutS_II; pfam05188 765952004510 MutS domain III; Region: MutS_III; pfam05192 765952004511 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 765952004512 Walker A/P-loop; other site 765952004513 ATP binding site [chemical binding]; other site 765952004514 Q-loop/lid; other site 765952004515 ABC transporter signature motif; other site 765952004516 Walker B; other site 765952004517 D-loop; other site 765952004518 H-loop/switch region; other site 765952004519 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 765952004520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952004521 active site 765952004522 motif I; other site 765952004523 motif II; other site 765952004524 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952004525 nudix motif; other site 765952004526 Dihydroneopterin aldolase; Region: FolB; pfam02152 765952004527 active site 765952004528 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 765952004529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004530 NAD(P) binding site [chemical binding]; other site 765952004531 active site 765952004532 enoyl-[acyl-carrier-protein] reductase; Region: PLN02730 765952004533 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 765952004534 NAD binding site [chemical binding]; other site 765952004535 homotetramer interface [polypeptide binding]; other site 765952004536 homodimer interface [polypeptide binding]; other site 765952004537 substrate binding site [chemical binding]; other site 765952004538 active site 765952004539 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 765952004540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952004541 dimer interface [polypeptide binding]; other site 765952004542 conserved gate region; other site 765952004543 ABC-ATPase subunit interface; other site 765952004544 NMT1/THI5 like; Region: NMT1; pfam09084 765952004545 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952004546 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 765952004547 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952004548 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952004549 RHS Repeat; Region: RHS_repeat; pfam05593 765952004550 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952004551 RHS Repeat; Region: RHS_repeat; pfam05593 765952004552 Family of unknown function (DUF3836); Region: DUF3836; pfam12930 765952004553 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952004554 Protein of unknown function (DUF687); Region: DUF687; pfam05095 765952004555 HEAT repeats; Region: HEAT_2; pfam13646 765952004556 HEAT repeats; Region: HEAT_2; pfam13646 765952004557 HEAT repeats; Region: HEAT_2; pfam13646 765952004558 HEAT repeats; Region: HEAT_2; pfam13646 765952004559 Isochorismatase family; Region: Isochorismatase; pfam00857 765952004560 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 765952004561 catalytic triad [active] 765952004562 dimer interface [polypeptide binding]; other site 765952004563 conserved cis-peptide bond; other site 765952004564 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 765952004565 nucleotide binding site/active site [active] 765952004566 HIT family signature motif; other site 765952004567 catalytic residue [active] 765952004568 Uncharacterized protein family (UPF0160); Region: UPF0160; cl01749 765952004569 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 765952004570 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 765952004571 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 765952004572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952004573 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 765952004574 Walker A/P-loop; other site 765952004575 ATP binding site [chemical binding]; other site 765952004576 Q-loop/lid; other site 765952004577 ABC transporter signature motif; other site 765952004578 Walker B; other site 765952004579 D-loop; other site 765952004580 H-loop/switch region; other site 765952004581 Domain of unknown function DUF87; Region: DUF87; pfam01935 765952004582 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 765952004583 Na binding site [ion binding]; other site 765952004584 Herpesvirus UL46 protein; Region: Herpes_UL46; cl17368 765952004585 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952004586 TLC ATP/ADP transporter; Region: TLC; cl03940 765952004587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952004588 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765952004589 Coenzyme A binding pocket [chemical binding]; other site 765952004590 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 765952004591 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 765952004592 EamA-like transporter family; Region: EamA; pfam00892 765952004593 Protein of unknown function (DUF952); Region: DUF952; cl01393 765952004594 Methyltransferase domain; Region: Methyltransf_23; pfam13489 765952004595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952004596 S-adenosylmethionine binding site [chemical binding]; other site 765952004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952004598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 765952004599 Coenzyme A binding pocket [chemical binding]; other site 765952004600 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952004601 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 765952004602 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 765952004603 putative NAD(P) binding site [chemical binding]; other site 765952004604 putative substrate binding site [chemical binding]; other site 765952004605 catalytic Zn binding site [ion binding]; other site 765952004606 structural Zn binding site [ion binding]; other site 765952004607 dimer interface [polypeptide binding]; other site 765952004608 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 765952004609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952004610 motif II; other site 765952004611 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952004612 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 765952004613 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952004614 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952004615 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952004616 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 765952004617 nudix motif; other site 765952004618 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 765952004619 nucleoside/Zn binding site; other site 765952004620 dimer interface [polypeptide binding]; other site 765952004621 catalytic motif [active] 765952004622 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 765952004623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952004624 hydroxyglutarate oxidase; Provisional; Region: PRK11728 765952004625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 765952004626 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 765952004627 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase protein; Reviewed; Region: aroDE; PRK09310 765952004628 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 765952004629 active site 765952004630 catalytic residue [active] 765952004631 dimer interface [polypeptide binding]; other site 765952004632 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 765952004633 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 765952004634 shikimate binding site; other site 765952004635 NAD(P) binding site [chemical binding]; other site 765952004636 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 765952004637 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 765952004638 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 765952004639 active site 765952004640 dimer interface [polypeptide binding]; other site 765952004641 metal binding site [ion binding]; metal-binding site 765952004642 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 765952004643 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 765952004644 Tetramer interface [polypeptide binding]; other site 765952004645 active site 765952004646 FMN-binding site [chemical binding]; other site 765952004647 shikimate kinase; Reviewed; Region: aroK; PRK00131 765952004648 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 765952004649 ADP binding site [chemical binding]; other site 765952004650 magnesium binding site [ion binding]; other site 765952004651 putative shikimate binding site; other site 765952004652 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 765952004653 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 765952004654 hinge; other site 765952004655 active site 765952004656 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 765952004657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952004658 motif II; other site 765952004659 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; cl17557 765952004660 Protein required for attachment to host cells; Region: Host_attach; pfam10116 765952004661 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 765952004662 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 765952004663 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952004664 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 765952004665 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 765952004666 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 765952004667 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 765952004668 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952004669 Soluble P-type ATPase [General function prediction only]; Region: COG4087 765952004670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952004671 active site 765952004672 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 765952004673 putative dimer interface [polypeptide binding]; other site 765952004674 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 765952004675 FtsX-like permease family; Region: FtsX; pfam02687 765952004676 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952004677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765952004678 Walker A/P-loop; other site 765952004679 ATP binding site [chemical binding]; other site 765952004680 Q-loop/lid; other site 765952004681 ABC transporter signature motif; other site 765952004682 Walker B; other site 765952004683 D-loop; other site 765952004684 H-loop/switch region; other site 765952004685 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 765952004686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952004687 active site 765952004688 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 765952004689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952004690 putative substrate translocation pore; other site 765952004691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952004692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004693 active site 765952004694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004695 NAD(P) binding site [chemical binding]; other site 765952004696 Chlamydia CHLPS protein (DUF818); Region: DUF818; pfam05677 765952004697 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 765952004698 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 765952004699 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 765952004700 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 765952004701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 765952004702 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 765952004703 alpha-glucosidase; Provisional; Region: PRK10137 765952004704 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 765952004705 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 765952004706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952004707 NAD(P) binding site [chemical binding]; other site 765952004708 active site 765952004709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952004710 putative substrate translocation pore; other site 765952004711 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952004712 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 765952004713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952004714 active site 765952004715 Uncharacterized conserved protein [Function unknown]; Region: COG1262 765952004716 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 765952004717 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 765952004718 Sulfatase; Region: Sulfatase; pfam00884 765952004719 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 765952004720 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 765952004721 dimer interface [polypeptide binding]; other site 765952004722 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765952004723 catalytic triad [active] 765952004724 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 765952004725 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 765952004726 catalytic residues [active] 765952004727 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952004728 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765952004729 active site 765952004730 catalytic tetrad [active] 765952004731 Domain of unknown function (DUF202); Region: DUF202; cl09954 765952004732 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 765952004733 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 765952004734 putative active site [active] 765952004735 putative metal binding site [ion binding]; other site 765952004736 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 765952004737 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952004738 Phosphotransferase enzyme family; Region: APH; pfam01636 765952004739 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 765952004740 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 765952004741 active site 765952004742 ATP binding site [chemical binding]; other site 765952004743 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952004744 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12646 765952004745 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 765952004746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 765952004747 non-specific DNA binding site [nucleotide binding]; other site 765952004748 salt bridge; other site 765952004749 sequence-specific DNA binding site [nucleotide binding]; other site 765952004750 D5 N terminal like; Region: D5_N; pfam08706 765952004751 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 765952004752 Helix-turn-helix domain; Region: HTH_17; cl17695 765952004753 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 765952004754 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 765952004755 active site 765952004756 DNA binding site [nucleotide binding] 765952004757 Int/Topo IB signature motif; other site 765952004758 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 765952004759 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 765952004760 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 765952004761 active site 765952004762 nucleophile elbow; other site 765952004763 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 765952004764 Lipase maturation factor; Region: LMF1; pfam06762 765952004765 putative phosphoketolase; Provisional; Region: PRK05261 765952004766 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 765952004767 TPP-binding site; other site 765952004768 XFP C-terminal domain; Region: XFP_C; pfam09363 765952004769 serine/threonine-protein kinase; Reviewed; Region: pknD; PRK13184 765952004770 Catalytic domain of Protein Kinases; Region: PKc; cd00180 765952004771 active site 765952004772 ATP binding site [chemical binding]; other site 765952004773 substrate binding site [chemical binding]; other site 765952004774 activation loop (A-loop); other site 765952004775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952004776 binding surface 765952004777 TPR motif; other site 765952004778 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 765952004779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 765952004780 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 765952004781 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 765952004782 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765952004783 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765952004784 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 765952004785 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 765952004786 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 765952004787 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 765952004788 active site 765952004789 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 765952004790 catalytic tetrad [active] 765952004791 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 765952004792 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 765952004793 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 765952004794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 765952004795 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 765952004796 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 765952004797 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 765952004798 active site 765952004799 PHP Thumb interface [polypeptide binding]; other site 765952004800 metal binding site [ion binding]; metal-binding site 765952004801 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 765952004802 generic binding surface II; other site 765952004803 generic binding surface I; other site 765952004804 regulatory protein UhpC; Provisional; Region: PRK11663 765952004805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952004806 putative substrate translocation pore; other site 765952004807 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Region: PLN02925 765952004808 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 765952004809 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 765952004810 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 765952004811 active site 765952004812 metal binding site [ion binding]; metal-binding site 765952004813 seryl-tRNA synthetase; Provisional; Region: PRK05431 765952004814 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 765952004815 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 765952004816 dimer interface [polypeptide binding]; other site 765952004817 active site 765952004818 motif 1; other site 765952004819 motif 2; other site 765952004820 motif 3; other site 765952004821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 765952004822 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 765952004823 active site 765952004824 3-ketoacyl-CoA thiolase; Provisional; Region: PTZ00455 765952004825 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 765952004826 active site 765952004827 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 765952004828 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 765952004829 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 765952004830 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 765952004831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 765952004832 substrate binding site [chemical binding]; other site 765952004833 oxyanion hole (OAH) forming residues; other site 765952004834 trimer interface [polypeptide binding]; other site 765952004835 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 765952004836 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 765952004837 tetramer interface [polypeptide binding]; other site 765952004838 active site 765952004839 Mg2+/Mn2+ binding site [ion binding]; other site 765952004840 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 765952004841 Citrate synthase; Region: Citrate_synt; pfam00285 765952004842 oxalacetate binding site [chemical binding]; other site 765952004843 citrylCoA binding site [chemical binding]; other site 765952004844 coenzyme A binding site [chemical binding]; other site 765952004845 catalytic triad [active] 765952004846 2-methylcitrate dehydratase; Region: prpD; TIGR02330 765952004847 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 765952004848 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 765952004849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 765952004850 active site 765952004851 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 765952004852 nucleophilic elbow; other site 765952004853 catalytic triad; other site 765952004854 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK01024 765952004855 FMN-binding domain; Region: FMN_bind; cl01081 765952004856 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 765952004857 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 765952004858 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 765952004859 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 765952004860 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 765952004861 homodimer interface [polypeptide binding]; other site 765952004862 active site pocket [active] 765952004863 Family description; Region: DsbD_2; pfam13386 765952004864 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952004865 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 765952004866 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 765952004867 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 765952004868 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 765952004869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952004870 dimer interface [polypeptide binding]; other site 765952004871 conserved gate region; other site 765952004872 putative PBP binding loops; other site 765952004873 ABC-ATPase subunit interface; other site 765952004874 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 765952004875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 765952004876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952004877 dimer interface [polypeptide binding]; other site 765952004878 conserved gate region; other site 765952004879 ABC-ATPase subunit interface; other site 765952004880 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 765952004881 DnaA N-terminal domain; Region: DnaA_N; pfam11638 765952004882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952004883 Walker A motif; other site 765952004884 ATP binding site [chemical binding]; other site 765952004885 Walker B motif; other site 765952004886 arginine finger; other site 765952004887 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 765952004888 DnaA box-binding interface [nucleotide binding]; other site 765952004889 ferrochelatase; Reviewed; Region: hemH; PRK00035 765952004890 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 765952004891 C-terminal domain interface [polypeptide binding]; other site 765952004892 active site 765952004893 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 765952004894 active site 765952004895 N-terminal domain interface [polypeptide binding]; other site 765952004896 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952004897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952004898 substrate binding pocket [chemical binding]; other site 765952004899 membrane-bound complex binding site; other site 765952004900 hinge residues; other site 765952004901 cytidylate kinase; Provisional; Region: cmk; PRK00023 765952004902 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 765952004903 CMP-binding site; other site 765952004904 The sites determining sugar specificity; other site 765952004905 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 765952004906 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 765952004907 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 765952004908 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 765952004909 catalytic residue [active] 765952004910 putative FPP diphosphate binding site; other site 765952004911 putative FPP binding hydrophobic cleft; other site 765952004912 dimer interface [polypeptide binding]; other site 765952004913 putative IPP diphosphate binding site; other site 765952004914 GTP-binding protein LepA; Provisional; Region: PRK05433 765952004915 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 765952004916 G1 box; other site 765952004917 putative GEF interaction site [polypeptide binding]; other site 765952004918 GTP/Mg2+ binding site [chemical binding]; other site 765952004919 Switch I region; other site 765952004920 G2 box; other site 765952004921 G3 box; other site 765952004922 Switch II region; other site 765952004923 G4 box; other site 765952004924 G5 box; other site 765952004925 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 765952004926 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 765952004927 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 765952004928 Thiamine pyrophosphokinase; Region: TPK; cd07995 765952004929 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 765952004930 active site 765952004931 dimerization interface [polypeptide binding]; other site 765952004932 thiamine binding site [chemical binding]; other site 765952004933 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 765952004934 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 765952004935 dimerization interface [polypeptide binding]; other site 765952004936 DPS ferroxidase diiron center [ion binding]; other site 765952004937 ion pore; other site 765952004938 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 765952004939 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 765952004940 putative NAD(P) binding site [chemical binding]; other site 765952004941 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 765952004942 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 765952004943 dimer interface [polypeptide binding]; other site 765952004944 putative CheW interface [polypeptide binding]; other site 765952004945 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 765952004946 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 765952004947 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 765952004948 alphaNTD homodimer interface [polypeptide binding]; other site 765952004949 alphaNTD - beta interaction site [polypeptide binding]; other site 765952004950 alphaNTD - beta' interaction site [polypeptide binding]; other site 765952004951 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 765952004952 30S ribosomal protein S11; Validated; Region: PRK05309 765952004953 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 765952004954 30S ribosomal protein S13; Region: bact_S13; TIGR03631 765952004955 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 765952004956 SecY translocase; Region: SecY; pfam00344 765952004957 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 765952004958 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 765952004959 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 765952004960 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 765952004961 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 765952004962 5S rRNA interface [nucleotide binding]; other site 765952004963 23S rRNA interface [nucleotide binding]; other site 765952004964 L5 interface [polypeptide binding]; other site 765952004965 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 765952004966 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765952004967 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 765952004968 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 765952004969 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 765952004970 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 765952004971 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 765952004972 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 765952004973 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 765952004974 RNA binding site [nucleotide binding]; other site 765952004975 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 765952004976 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 765952004977 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 765952004978 putative translocon interaction site; other site 765952004979 23S rRNA interface [nucleotide binding]; other site 765952004980 signal recognition particle (SRP54) interaction site; other site 765952004981 L23 interface [polypeptide binding]; other site 765952004982 trigger factor interaction site; other site 765952004983 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 765952004984 23S rRNA interface [nucleotide binding]; other site 765952004985 5S rRNA interface [nucleotide binding]; other site 765952004986 putative antibiotic binding site [chemical binding]; other site 765952004987 L25 interface [polypeptide binding]; other site 765952004988 L27 interface [polypeptide binding]; other site 765952004989 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 765952004990 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 765952004991 G-X-X-G motif; other site 765952004992 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 765952004993 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 765952004994 putative translocon binding site; other site 765952004995 protein-rRNA interface [nucleotide binding]; other site 765952004996 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 765952004997 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 765952004998 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 765952004999 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 765952005000 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 765952005001 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 765952005002 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 765952005003 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 765952005004 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 765952005005 putative active site [active] 765952005006 substrate binding site [chemical binding]; other site 765952005007 putative cosubstrate binding site; other site 765952005008 catalytic site [active] 765952005009 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 765952005010 substrate binding site [chemical binding]; other site 765952005011 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 765952005012 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 765952005013 active site 765952005014 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 765952005015 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 765952005016 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 765952005017 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 765952005018 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 765952005019 putative active site [active] 765952005020 catalytic triad [active] 765952005021 putative dimer interface [polypeptide binding]; other site 765952005022 Predicted membrane protein [Function unknown]; Region: COG2259 765952005023 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 765952005024 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 765952005025 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 765952005026 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 765952005027 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 765952005028 active site 765952005029 HIGH motif; other site 765952005030 nucleotide binding site [chemical binding]; other site 765952005031 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 765952005032 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 765952005033 active site 765952005034 KMSKS motif; other site 765952005035 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 765952005036 tRNA binding surface [nucleotide binding]; other site 765952005037 anticodon binding site; other site 765952005038 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 765952005039 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952005040 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952005041 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 765952005042 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 765952005043 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 765952005044 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 765952005045 V-type ATP synthase subunit K; Provisional; Region: PRK09621 765952005046 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 765952005047 V-type ATP synthase subunit I; Validated; Region: PRK05771 765952005048 ATP synthase subunit D; Region: ATP-synt_D; cl00613 765952005049 V-type ATP synthase subunit B; Provisional; Region: PRK02118 765952005050 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765952005051 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 765952005052 Walker A motif homologous position; other site 765952005053 Walker B motif; other site 765952005054 V-type ATP synthase subunit A; Provisional; Region: PRK04192 765952005055 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765952005056 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 765952005057 Walker A motif/ATP binding site; other site 765952005058 Walker B motif; other site 765952005059 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765952005060 Protein of unknown function (DUF2764); Region: DUF2764; pfam10962 765952005061 V-type ATP synthase subunit E; Provisional; Region: PRK01005 765952005062 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005064 NAD(P) binding site [chemical binding]; other site 765952005065 active site 765952005066 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 765952005067 putative active site [active] 765952005068 redox center [active] 765952005069 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005070 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005071 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005072 MULE transposase domain; Region: MULE; pfam10551 765952005073 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005074 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005075 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 765952005077 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 765952005078 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 765952005079 gamma subunit interface [polypeptide binding]; other site 765952005080 epsilon subunit interface [polypeptide binding]; other site 765952005081 LBP interface [polypeptide binding]; other site 765952005082 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 765952005083 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765952005084 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 765952005085 alpha subunit interaction interface [polypeptide binding]; other site 765952005086 Walker A motif; other site 765952005087 ATP binding site [chemical binding]; other site 765952005088 Walker B motif; other site 765952005089 inhibitor binding site; inhibition site 765952005090 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765952005091 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 765952005092 core domain interface [polypeptide binding]; other site 765952005093 delta subunit interface [polypeptide binding]; other site 765952005094 epsilon subunit interface [polypeptide binding]; other site 765952005095 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 765952005096 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 765952005097 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 765952005098 beta subunit interaction interface [polypeptide binding]; other site 765952005099 Walker A motif; other site 765952005100 ATP binding site [chemical binding]; other site 765952005101 Walker B motif; other site 765952005102 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 765952005103 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 765952005104 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 765952005105 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 765952005106 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 765952005107 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 765952005108 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 765952005109 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 765952005110 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 765952005111 transaldolase-like protein; Provisional; Region: PTZ00411 765952005112 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 765952005113 active site 765952005114 dimer interface [polypeptide binding]; other site 765952005115 catalytic residue [active] 765952005116 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 765952005117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952005118 Walker A motif; other site 765952005119 ATP binding site [chemical binding]; other site 765952005120 Walker B motif; other site 765952005121 arginine finger; other site 765952005122 Peptidase family M41; Region: Peptidase_M41; pfam01434 765952005123 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 765952005124 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 765952005125 Ligand Binding Site [chemical binding]; other site 765952005126 TilS substrate C-terminal domain; Region: TilS_C; cl17443 765952005127 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 765952005128 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 765952005129 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 765952005130 Predicted permeases [General function prediction only]; Region: COG0795 765952005131 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 765952005132 putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930 765952005133 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 765952005134 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 765952005135 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 765952005136 active site 765952005137 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 765952005138 dimer interface [polypeptide binding]; other site 765952005139 substrate binding site [chemical binding]; other site 765952005140 catalytic residues [active] 765952005141 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 765952005142 RloB-like protein; Region: RloB; pfam13707 765952005143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952005144 AAA domain; Region: AAA_21; pfam13304 765952005145 Walker A/P-loop; other site 765952005146 ATP binding site [chemical binding]; other site 765952005147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005148 NADH(P)-binding; Region: NAD_binding_10; pfam13460 765952005149 NAD(P) binding site [chemical binding]; other site 765952005150 active site 765952005151 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 765952005152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005153 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 765952005154 nudix motif; other site 765952005155 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 765952005156 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 765952005157 PhnA protein; Region: PhnA; pfam03831 765952005158 short chain dehydrogenase; Provisional; Region: PRK06180 765952005159 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 765952005160 NADP binding site [chemical binding]; other site 765952005161 active site 765952005162 steroid binding site; other site 765952005163 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 765952005164 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 765952005165 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 765952005166 putative NAD(P) binding site [chemical binding]; other site 765952005167 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 765952005168 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 765952005169 phosphate binding site [ion binding]; other site 765952005170 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 765952005171 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 765952005172 FMN binding site [chemical binding]; other site 765952005173 substrate binding site [chemical binding]; other site 765952005174 putative catalytic residue [active] 765952005175 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005177 NAD(P) binding site [chemical binding]; other site 765952005178 active site 765952005179 Pirin-related protein [General function prediction only]; Region: COG1741 765952005180 Pirin; Region: Pirin; pfam02678 765952005181 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 765952005182 Cupin; Region: Cupin_1; smart00835 765952005183 Cupin; Region: Cupin_1; smart00835 765952005184 short chain dehydrogenase; Provisional; Region: PRK06500 765952005185 classical (c) SDRs; Region: SDR_c; cd05233 765952005186 NAD(P) binding site [chemical binding]; other site 765952005187 active site 765952005188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952005190 Walker A motif; other site 765952005191 ATP binding site [chemical binding]; other site 765952005192 Walker B motif; other site 765952005193 arginine finger; other site 765952005194 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 765952005195 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 765952005196 ATP binding site [chemical binding]; other site 765952005197 Walker B motif; other site 765952005198 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 765952005199 short chain dehydrogenase; Provisional; Region: PRK06500 765952005200 classical (c) SDRs; Region: SDR_c; cd05233 765952005201 NAD(P) binding site [chemical binding]; other site 765952005202 active site 765952005203 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 765952005204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765952005205 ABC transporter; Region: ABC_tran_2; pfam12848 765952005206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 765952005207 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 765952005208 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 765952005209 Multicopper oxidase; Region: Cu-oxidase; pfam00394 765952005210 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 765952005211 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 765952005212 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 765952005213 classical (c) SDRs; Region: SDR_c; cd05233 765952005214 NAD(P) binding site [chemical binding]; other site 765952005215 active site 765952005216 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 765952005217 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 765952005218 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 765952005219 Zn2+ binding site [ion binding]; other site 765952005220 Mg2+ binding site [ion binding]; other site 765952005221 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 765952005222 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 765952005223 NAD binding site [chemical binding]; other site 765952005224 homodimer interface [polypeptide binding]; other site 765952005225 active site 765952005226 substrate binding site [chemical binding]; other site 765952005227 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 765952005228 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06305 765952005229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 765952005230 Walker A motif; other site 765952005231 ATP binding site [chemical binding]; other site 765952005232 Walker B motif; other site 765952005233 arginine finger; other site 765952005234 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 765952005235 hypothetical protein; Validated; Region: PRK00153 765952005236 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 765952005237 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 765952005238 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 765952005239 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 765952005240 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 765952005241 dimerization domain swap beta strand [polypeptide binding]; other site 765952005242 regulatory protein interface [polypeptide binding]; other site 765952005243 active site 765952005244 regulatory phosphorylation site [posttranslational modification]; other site 765952005245 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 765952005246 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 765952005247 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 765952005248 Hpr binding site; other site 765952005249 active site 765952005250 homohexamer subunit interaction site [polypeptide binding]; other site 765952005251 Uncharacterized protein family (UPF0242); Region: UPF0242; pfam06785 765952005252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 765952005253 active site 765952005254 phosphorylation site [posttranslational modification] 765952005255 intermolecular recognition site; other site 765952005256 dimerization interface [polypeptide binding]; other site 765952005257 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 765952005258 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 765952005259 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 765952005260 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 765952005261 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 765952005262 anti sigma factor interaction site; other site 765952005263 regulatory phosphorylation site [posttranslational modification]; other site 765952005264 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 765952005265 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 765952005266 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 765952005267 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 765952005268 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 765952005269 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 765952005270 NAD binding site [chemical binding]; other site 765952005271 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 765952005272 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 765952005273 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 765952005274 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 765952005275 active site 765952005276 metal-binding site 765952005277 Predicted acyl esterases [General function prediction only]; Region: COG2936 765952005278 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 765952005279 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 765952005280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 765952005281 motif II; other site 765952005282 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 765952005283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005284 putative substrate translocation pore; other site 765952005285 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 765952005286 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 765952005287 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 765952005288 Outer membrane efflux protein; Region: OEP; pfam02321 765952005289 Outer membrane efflux protein; Region: OEP; pfam02321 765952005290 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952005291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952005292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765952005293 Walker A/P-loop; other site 765952005294 ATP binding site [chemical binding]; other site 765952005295 Q-loop/lid; other site 765952005296 ABC transporter signature motif; other site 765952005297 Walker B; other site 765952005298 D-loop; other site 765952005299 H-loop/switch region; other site 765952005300 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765952005301 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 765952005302 FtsX-like permease family; Region: FtsX; pfam02687 765952005303 Competence protein CoiA-like family; Region: CoiA; cl11541 765952005304 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 765952005305 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 765952005306 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 765952005307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 765952005308 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 765952005309 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 765952005310 DNA binding residues [nucleotide binding] 765952005311 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 765952005312 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 765952005313 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 765952005314 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765952005315 Bacitracin resistance protein BacA; Region: BacA; pfam02673 765952005316 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 765952005317 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 765952005318 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 765952005319 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 765952005320 AAA domain; Region: AAA_32; pfam13654 765952005321 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 765952005322 chaperone protein DnaJ; Provisional; Region: PRK14284 765952005323 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 765952005324 HSP70 interaction site [polypeptide binding]; other site 765952005325 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 765952005326 Zn binding sites [ion binding]; other site 765952005327 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 765952005328 dimer interface [polypeptide binding]; other site 765952005329 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 765952005330 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 765952005331 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 765952005332 Predicted GTPases [General function prediction only]; Region: COG1162 765952005333 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 765952005334 RNA binding site [nucleotide binding]; other site 765952005335 homodimer interface [polypeptide binding]; other site 765952005336 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 765952005337 GTPase/Zn-binding domain interface [polypeptide binding]; other site 765952005338 GTP/Mg2+ binding site [chemical binding]; other site 765952005339 G4 box; other site 765952005340 G5 box; other site 765952005341 G1 box; other site 765952005342 Switch I region; other site 765952005343 G2 box; other site 765952005344 G3 box; other site 765952005345 Switch II region; other site 765952005346 enolase; Provisional; Region: eno; PRK00077 765952005347 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 765952005348 dimer interface [polypeptide binding]; other site 765952005349 metal binding site [ion binding]; metal-binding site 765952005350 substrate binding pocket [chemical binding]; other site 765952005351 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 765952005352 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 765952005353 active site 765952005354 catalytic site [active] 765952005355 lipoprotein signal peptidase; Provisional; Region: PRK14787 765952005356 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 765952005357 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 765952005358 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 765952005359 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 765952005360 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 765952005361 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 765952005362 Phosphoglycerate kinase; Region: PGK; pfam00162 765952005363 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 765952005364 substrate binding site [chemical binding]; other site 765952005365 hinge regions; other site 765952005366 ADP binding site [chemical binding]; other site 765952005367 catalytic site [active] 765952005368 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952005369 TLC ATP/ADP transporter; Region: TLC; pfam03219 765952005370 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 765952005371 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 765952005372 Dimer interface [polypeptide binding]; other site 765952005373 anticodon binding site; other site 765952005374 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765952005375 motif 1; other site 765952005376 dimer interface [polypeptide binding]; other site 765952005377 active site 765952005378 motif 2; other site 765952005379 motif 3; other site 765952005380 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 765952005381 putative deacylase active site [active] 765952005382 thiamine monophosphate kinase; Provisional; Region: PRK05731 765952005383 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 765952005384 ATP binding site [chemical binding]; other site 765952005385 dimerization interface [polypeptide binding]; other site 765952005386 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 765952005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952005389 putative substrate translocation pore; other site 765952005390 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 765952005391 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 765952005392 transmembrane helices; other site 765952005393 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 765952005394 Peptidase family M50; Region: Peptidase_M50; pfam02163 765952005395 active site 765952005396 putative substrate binding region [chemical binding]; other site 765952005397 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 765952005398 binding surface 765952005399 TPR motif; other site 765952005400 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 765952005401 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 765952005402 CoA binding domain; Region: CoA_binding; smart00881 765952005403 CoA-ligase; Region: Ligase_CoA; pfam00549 765952005404 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 765952005405 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 765952005406 CoA-ligase; Region: Ligase_CoA; pfam00549 765952005407 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 765952005408 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 765952005409 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 765952005410 P loop; other site 765952005411 GTP binding site [chemical binding]; other site 765952005412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005414 active site 765952005415 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005416 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 765952005417 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 765952005419 MULE transposase domain; Region: MULE; pfam10551 765952005420 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 765952005421 short chain dehydrogenase; Provisional; Region: PRK08278 765952005422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005423 NAD(P) binding site [chemical binding]; other site 765952005424 active site 765952005425 V-type ATPase 116kDa subunit family; Region: V_ATPase_I; pfam01496 765952005426 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 765952005427 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 765952005428 Uncharacterized conserved protein [Function unknown]; Region: COG1262 765952005429 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 765952005430 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 765952005431 active site 765952005432 metal binding site [ion binding]; metal-binding site 765952005433 heat shock protein 90; Provisional; Region: PRK05218 765952005434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952005435 ATP binding site [chemical binding]; other site 765952005436 Mg2+ binding site [ion binding]; other site 765952005437 G-X-G motif; other site 765952005438 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 765952005439 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 765952005440 putative metal binding residues [ion binding]; other site 765952005441 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 765952005442 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 765952005443 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 765952005444 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 765952005445 ABC-ATPase subunit interface; other site 765952005446 dimer interface [polypeptide binding]; other site 765952005447 putative PBP binding regions; other site 765952005448 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 765952005449 putative active site pocket [active] 765952005450 dimerization interface [polypeptide binding]; other site 765952005451 putative catalytic residue [active] 765952005452 Transposase, Mutator family; Region: Transposase_mut; pfam00872 765952005453 MULE transposase domain; Region: MULE; pfam10551 765952005454 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 765952005455 nudix motif; other site 765952005456 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 765952005457 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 765952005458 active site 765952005459 FMN binding site [chemical binding]; other site 765952005460 substrate binding site [chemical binding]; other site 765952005461 homotetramer interface [polypeptide binding]; other site 765952005462 catalytic residue [active] 765952005463 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 765952005464 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 765952005465 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952005466 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 765952005467 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 765952005468 Na binding site [ion binding]; other site 765952005469 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 765952005470 Divergent AAA domain; Region: AAA_4; pfam04326 765952005471 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 765952005472 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 765952005473 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 765952005474 dimer interface [polypeptide binding]; other site 765952005475 motif 1; other site 765952005476 active site 765952005477 motif 2; other site 765952005478 motif 3; other site 765952005479 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 765952005480 anticodon binding site; other site 765952005481 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 765952005482 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 765952005483 dimer interface [polypeptide binding]; other site 765952005484 anticodon binding site; other site 765952005485 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 765952005486 homodimer interface [polypeptide binding]; other site 765952005487 motif 1; other site 765952005488 active site 765952005489 motif 2; other site 765952005490 GAD domain; Region: GAD; pfam02938 765952005491 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765952005492 active site 765952005493 motif 3; other site 765952005494 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 765952005495 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 765952005496 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765952005497 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 765952005498 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 765952005499 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 765952005500 catalytic residues [active] 765952005501 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 765952005502 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 765952005503 active site 765952005504 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 765952005505 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 765952005506 active site residue [active] 765952005507 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 765952005508 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 765952005509 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 765952005510 Histone H1-like protein Hc1; Region: Hc1; pfam07432 765952005511 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 765952005512 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 765952005513 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765952005514 minor groove reading motif; other site 765952005515 helix-hairpin-helix signature motif; other site 765952005516 substrate binding pocket [chemical binding]; other site 765952005517 active site 765952005518 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 765952005519 DNA binding and oxoG recognition site [nucleotide binding] 765952005520 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 765952005521 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 765952005522 putative active site [active] 765952005523 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 765952005524 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 765952005525 active site 765952005526 putative DNA-binding cleft [nucleotide binding]; other site 765952005527 dimer interface [polypeptide binding]; other site 765952005528 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 765952005529 RuvA N terminal domain; Region: RuvA_N; pfam01330 765952005530 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 765952005531 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 765952005532 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 765952005533 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 765952005534 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 765952005535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 765952005536 S-adenosylmethionine binding site [chemical binding]; other site 765952005537 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 765952005538 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005539 active site 765952005540 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952005541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952005542 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 765952005543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005544 active site 765952005545 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952005546 TPR motif; other site 765952005547 binding surface 765952005548 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 765952005549 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 765952005550 Protein of unknown function (DUF1494); Region: DUF1494; pfam07379 765952005551 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 765952005552 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 765952005553 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 765952005554 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 765952005555 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 765952005556 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 765952005557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 765952005558 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 765952005559 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 765952005560 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 765952005561 Walker A motif; other site 765952005562 ATP binding site [chemical binding]; other site 765952005563 Walker B motif; other site 765952005564 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 765952005565 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 765952005566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952005568 putative substrate translocation pore; other site 765952005569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 765952005573 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 765952005574 homotrimer interaction site [polypeptide binding]; other site 765952005575 putative active site [active] 765952005576 replicative DNA helicase; Provisional; Region: PRK06321 765952005577 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 765952005578 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 765952005579 Walker A motif; other site 765952005580 ATP binding site [chemical binding]; other site 765952005581 Walker B motif; other site 765952005582 DNA binding loops [nucleotide binding] 765952005583 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 765952005584 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 765952005585 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 765952005586 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 765952005587 glutaminase active site [active] 765952005588 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 765952005589 dimer interface [polypeptide binding]; other site 765952005590 active site 765952005591 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 765952005592 dimer interface [polypeptide binding]; other site 765952005593 active site 765952005594 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 765952005595 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 765952005596 active site 765952005597 substrate binding site [chemical binding]; other site 765952005598 metal binding site [ion binding]; metal-binding site 765952005599 F-box-like; Region: F-box-like; pfam12937 765952005600 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 765952005601 FOG: WD40 repeat [General function prediction only]; Region: COG2319 765952005602 structural tetrad; other site 765952005603 Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular...; Region: FReD; cl00085 765952005604 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 765952005605 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 765952005606 minor groove reading motif; other site 765952005607 helix-hairpin-helix signature motif; other site 765952005608 substrate binding pocket [chemical binding]; other site 765952005609 active site 765952005610 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 765952005611 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 765952005612 trmE is a tRNA modification GTPase; Region: trmE; cd04164 765952005613 G1 box; other site 765952005614 GTP/Mg2+ binding site [chemical binding]; other site 765952005615 Switch I region; other site 765952005616 G2 box; other site 765952005617 Switch II region; other site 765952005618 G3 box; other site 765952005619 G4 box; other site 765952005620 G5 box; other site 765952005621 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 765952005622 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 765952005623 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 765952005624 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 765952005625 putative active site; other site 765952005626 catalytic residue [active] 765952005627 MoxR-like ATPases [General function prediction only]; Region: COG0714 765952005628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 765952005629 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 765952005630 hypothetical protein; Provisional; Region: PRK08201 765952005631 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 765952005632 metal binding site [ion binding]; metal-binding site 765952005633 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 765952005634 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952005635 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 765952005636 lipoyl synthase; Provisional; Region: PRK05481 765952005637 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 765952005638 FeS/SAM binding site; other site 765952005639 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 765952005640 arginine-tRNA ligase; Region: PLN02286 765952005641 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 765952005642 active site 765952005643 HIGH motif; other site 765952005644 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 765952005645 KMSK motif region; other site 765952005646 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 765952005647 tRNA binding surface [nucleotide binding]; other site 765952005648 anticodon binding site; other site 765952005649 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 765952005650 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 765952005651 tetramer interface [polypeptide binding]; other site 765952005652 heme binding pocket [chemical binding]; other site 765952005653 NADPH binding site [chemical binding]; other site 765952005654 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 765952005655 aromatic amino acid transport protein; Region: araaP; TIGR00837 765952005656 Protein of unknown function (DUF3638); Region: DUF3638; pfam12340 765952005657 Protein of unknown function (DUF342); Region: DUF342; pfam03961 765952005658 prolyl-tRNA synthetase; Provisional; Region: PRK08661 765952005659 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 765952005660 dimer interface [polypeptide binding]; other site 765952005661 motif 1; other site 765952005662 active site 765952005663 motif 2; other site 765952005664 motif 3; other site 765952005665 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 765952005666 anticodon binding site; other site 765952005667 zinc-binding site [ion binding]; other site 765952005668 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 765952005669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005670 putative substrate translocation pore; other site 765952005671 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 765952005672 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952005673 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 765952005674 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 765952005675 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 765952005676 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 765952005677 Ligand Binding Site [chemical binding]; other site 765952005678 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 765952005679 GAF domain; Region: GAF_3; pfam13492 765952005680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 765952005681 dimer interface [polypeptide binding]; other site 765952005682 phosphorylation site [posttranslational modification] 765952005683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 765952005684 ATP binding site [chemical binding]; other site 765952005685 Mg2+ binding site [ion binding]; other site 765952005686 G-X-G motif; other site 765952005687 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 765952005688 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 765952005689 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 765952005690 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 765952005691 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005692 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005693 RHS Repeat; Region: RHS_repeat; cl11982 765952005694 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952005696 Major Facilitator Superfamily; Region: MFS_1; pfam07690 765952005697 putative substrate translocation pore; other site 765952005698 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 765952005699 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 765952005700 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 765952005701 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 765952005702 active site 765952005703 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005704 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 765952005705 extended (e) SDRs; Region: SDR_e; cd08946 765952005706 NAD(P) binding site [chemical binding]; other site 765952005707 active site 765952005708 substrate binding site [chemical binding]; other site 765952005709 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 765952005710 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 765952005711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005712 NAD(P) binding site [chemical binding]; other site 765952005713 active site 765952005714 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 765952005715 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 765952005716 active site 765952005717 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 765952005718 Na binding site [ion binding]; other site 765952005719 Protein of unknown function (DUF917); Region: DUF917; pfam06032 765952005720 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 765952005721 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 765952005722 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 765952005723 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 765952005724 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 765952005725 motif 1; other site 765952005726 dimer interface [polypeptide binding]; other site 765952005727 active site 765952005728 motif 2; other site 765952005729 motif 3; other site 765952005730 translation elongation factor P; Region: efp; TIGR00038 765952005731 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 765952005732 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 765952005733 RNA binding site [nucleotide binding]; other site 765952005734 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 765952005735 RNA binding site [nucleotide binding]; other site 765952005736 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 765952005737 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 765952005738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952005739 TPR repeat; Region: TPR_11; pfam13414 765952005740 TPR motif; other site 765952005741 binding surface 765952005742 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 765952005743 nucleotide binding site/active site [active] 765952005744 HIT family signature motif; other site 765952005745 catalytic residue [active] 765952005746 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 765952005747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765952005748 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 765952005749 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765952005750 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 765952005751 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 765952005752 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 765952005753 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 765952005754 NADH-ubiquinone/plastoquinone oxidoreductase chain 6; Region: Oxidored_q3; pfam00499 765952005755 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 765952005756 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 765952005757 4Fe-4S binding domain; Region: Fer4; pfam00037 765952005758 4Fe-4S binding domain; Region: Fer4; pfam00037 765952005759 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 765952005760 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 765952005761 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 765952005762 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 765952005763 catalytic loop [active] 765952005764 iron binding site [ion binding]; other site 765952005765 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 765952005766 MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768 765952005767 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 765952005768 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 765952005769 SLBB domain; Region: SLBB; pfam10531 765952005770 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 765952005771 NADH dehydrogenase subunit E; Validated; Region: PRK07539 765952005772 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 765952005773 putative dimer interface [polypeptide binding]; other site 765952005774 [2Fe-2S] cluster binding site [ion binding]; other site 765952005775 NADH dehydrogenase subunit D; Validated; Region: PRK06075 765952005776 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 765952005777 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 765952005778 NADH dehydrogenase subunit B; Validated; Region: PRK06411 765952005779 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 765952005780 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 765952005781 Methyltransferase domain; Region: Methyltransf_18; pfam12847 765952005782 S-adenosylmethionine binding site [chemical binding]; other site 765952005783 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 765952005784 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 765952005785 Low-spin heme binding site [chemical binding]; other site 765952005786 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 765952005787 D-pathway; other site 765952005788 Putative water exit pathway; other site 765952005789 Binuclear center (active site) [active] 765952005790 K-pathway; other site 765952005791 Putative proton exit pathway; other site 765952005792 Cytochrome c; Region: Cytochrom_C; pfam00034 765952005793 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 765952005794 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 765952005795 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 765952005796 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 765952005797 interchain domain interface [polypeptide binding]; other site 765952005798 intrachain domain interface; other site 765952005799 heme bL binding site [chemical binding]; other site 765952005800 heme bH binding site [chemical binding]; other site 765952005801 Qo binding site; other site 765952005802 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 765952005803 iron-sulfur cluster [ion binding]; other site 765952005804 [2Fe-2S] cluster binding site [ion binding]; other site 765952005805 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253 765952005806 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 765952005807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 765952005808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 765952005809 4Fe-4S binding domain; Region: Fer4; pfam00037 765952005810 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765952005811 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 765952005812 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 765952005813 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 765952005814 dimer interface [polypeptide binding]; other site 765952005815 active site 765952005816 Proline dehydrogenase; Region: Pro_dh; cl03282 765952005817 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 765952005818 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 765952005819 Glutamate binding site [chemical binding]; other site 765952005820 NAD binding site [chemical binding]; other site 765952005821 catalytic residues [active] 765952005822 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 765952005823 Part of AAA domain; Region: AAA_19; pfam13245 765952005824 Family description; Region: UvrD_C_2; pfam13538 765952005825 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 765952005826 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 765952005827 Integrase core domain; Region: rve_3; cl15866 765952005828 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 765952005829 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 765952005830 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 765952005831 active site 765952005832 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 765952005833 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765952005834 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 765952005835 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765952005836 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 765952005837 pseudouridine synthase; Region: TIGR00093 765952005838 active site 765952005839 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 765952005840 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 765952005841 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 765952005842 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 765952005843 dimer interface [polypeptide binding]; other site 765952005844 allosteric magnesium binding site [ion binding]; other site 765952005845 active site 765952005846 aspartate-rich active site metal binding site; other site 765952005847 Schiff base residues; other site 765952005848 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 765952005849 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 765952005850 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 765952005851 catalytic triad [active] 765952005852 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 765952005853 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 765952005854 putative metal binding site; other site 765952005855 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005856 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005857 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 765952005858 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 765952005859 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 765952005860 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 765952005861 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 765952005862 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 765952005863 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765952005864 protein binding site [polypeptide binding]; other site 765952005865 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 765952005866 protein binding site [polypeptide binding]; other site 765952005867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 765952005868 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 765952005869 substrate binding pocket [chemical binding]; other site 765952005870 membrane-bound complex binding site; other site 765952005871 hinge residues; other site 765952005872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 765952005873 dimer interface [polypeptide binding]; other site 765952005874 conserved gate region; other site 765952005875 putative PBP binding loops; other site 765952005876 ABC-ATPase subunit interface; other site 765952005877 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 765952005878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 765952005879 Walker A/P-loop; other site 765952005880 ATP binding site [chemical binding]; other site 765952005881 Q-loop/lid; other site 765952005882 ABC transporter signature motif; other site 765952005883 Walker B; other site 765952005884 D-loop; other site 765952005885 H-loop/switch region; other site 765952005886 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 765952005887 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 765952005888 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 765952005889 DevC protein; Region: devC; TIGR01185 765952005890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 765952005891 FtsX-like permease family; Region: FtsX; pfam02687 765952005892 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 765952005893 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 765952005894 Walker A/P-loop; other site 765952005895 ATP binding site [chemical binding]; other site 765952005896 Q-loop/lid; other site 765952005897 ABC transporter signature motif; other site 765952005898 Walker B; other site 765952005899 D-loop; other site 765952005900 H-loop/switch region; other site 765952005901 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 765952005902 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 765952005903 HlyD family secretion protein; Region: HlyD_3; pfam13437 765952005904 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 765952005905 PLD-like domain; Region: PLDc_2; pfam13091 765952005906 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 765952005907 putative active site [active] 765952005908 catalytic site [active] 765952005909 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 765952005910 PLD-like domain; Region: PLDc_2; pfam13091 765952005911 putative active site [active] 765952005912 catalytic site [active] 765952005913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 765952005914 YheO-like PAS domain; Region: PAS_6; pfam08348 765952005915 HTH domain; Region: HTH_22; pfam13309 765952005916 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 765952005917 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 765952005918 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 765952005919 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 765952005920 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 765952005921 active site 765952005922 dimer interface [polypeptide binding]; other site 765952005923 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 765952005924 Ligand Binding Site [chemical binding]; other site 765952005925 Molecular Tunnel; other site 765952005926 Bordetella bronchiseptica enzymes WbmH and WbmG-like, extended (e) SDRs; Region: WbmH_like_SDR_e; cd08957 765952005927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005928 NAD binding site [chemical binding]; other site 765952005929 homodimer interface [polypeptide binding]; other site 765952005930 active site 765952005931 putative substrate binding site [chemical binding]; other site 765952005932 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 765952005933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952005934 NAD(P) binding site [chemical binding]; other site 765952005935 active site 765952005936 Domain of unknown function DUF21; Region: DUF21; pfam01595 765952005937 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 765952005938 EamA-like transporter family; Region: EamA; pfam00892 765952005939 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 765952005940 EamA-like transporter family; Region: EamA; pfam00892 765952005941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 765952005942 TPR motif; other site 765952005943 binding surface 765952005944 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 765952005945 Double zinc ribbon; Region: DZR; pfam12773 765952005946 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 765952005947 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 765952005948 active site 765952005949 NTP binding site [chemical binding]; other site 765952005950 metal binding triad [ion binding]; metal-binding site 765952005951 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 765952005952 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 765952005953 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 765952005954 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 765952005955 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 765952005956 active site 765952005957 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 765952005958 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 765952005959 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 765952005960 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 765952005961 DsbD alpha interface [polypeptide binding]; other site 765952005962 catalytic residues [active] 765952005963 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 765952005964 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 765952005965 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 765952005966 translocation protein TolB; Provisional; Region: tolB; PRK01029 765952005967 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 765952005968 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 765952005969 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 765952005970 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 765952005971 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 765952005972 dimer interface [polypeptide binding]; other site 765952005973 decamer (pentamer of dimers) interface [polypeptide binding]; other site 765952005974 catalytic triad [active] 765952005975 peroxidatic and resolving cysteines [active] 765952005976 Protein of unknown function (DUF2851); Region: DUF2851; pfam11013 765952005977 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005978 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 765952005979 RHS Repeat; Region: RHS_repeat; cl11982 765952005980 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 765952005981 transcriptional regulator InvF; Provisional; Region: PRK15340 765952005982 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 765952005983 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 765952005984 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 765952005985 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 765952005986 active site 765952005987 dimer interface [polypeptide binding]; other site 765952005988 motif 1; other site 765952005989 motif 2; other site 765952005990 motif 3; other site 765952005991 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 765952005992 anticodon binding site; other site 765952005993 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 765952005994 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 765952005995 Uncharacterized protein family (UPF0137); Region: UPF0137; pfam03677 765952005996 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 765952005997 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 765952005998 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 765952005999 BioY family; Region: BioY; pfam02632 765952006000 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 765952006001 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 765952006002 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 765952006003 NAD binding site [chemical binding]; other site 765952006004 Phe binding site; other site 765952006005 Protein of unknown function (DUF2709); Region: DUF2709; pfam10915 765952006006 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 765952006007 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 765952006008 G1 box; other site 765952006009 GTP/Mg2+ binding site [chemical binding]; other site 765952006010 Switch I region; other site 765952006011 G2 box; other site 765952006012 G3 box; other site 765952006013 Switch II region; other site 765952006014 G4 box; other site 765952006015 G5 box; other site 765952006016 DNA polymerase III subunit epsilon; Validated; Region: PRK06310 765952006017 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 765952006018 active site 765952006019 catalytic site [active] 765952006020 substrate binding site [chemical binding]; other site 765952006021 Protein of unknown function (DUF3820); Region: DUF3820; cl01411 765952006022 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 765952006023 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 765952006024 active site 765952006025 multimer interface [polypeptide binding]; other site 765952006026 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 765952006027 predicted active site [active] 765952006028 catalytic triad [active] 765952006029 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 765952006030 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 765952006031 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 765952006032 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 765952006033 Probable Catalytic site; other site 765952006034 metal-binding site 765952006035 Uncharacterized conserved protein [Function unknown]; Region: COG5361 765952006036 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 765952006037 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 765952006038 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 765952006039 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 765952006040 acyl-activating enzyme (AAE) consensus motif; other site 765952006041 AMP binding site [chemical binding]; other site 765952006042 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 765952006043 Condensation domain; Region: Condensation; pfam00668 765952006044 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 765952006045 thioester reductase domain; Region: Thioester-redct; TIGR01746 765952006046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 765952006047 NAD(P) binding site [chemical binding]; other site 765952006048 active site 765952006049 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 765952006050 classical (c) SDRs; Region: SDR_c; cd05233 765952006051 NAD(P) binding site [chemical binding]; other site 765952006052 active site 765952006053 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 765952006054 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 765952006055 acyl-activating enzyme (AAE) consensus motif; other site 765952006056 AMP binding site [chemical binding]; other site 765952006057 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 765952006058 Condensation domain; Region: Condensation; pfam00668 765952006059 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 765952006060 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 765952006061 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 765952006062 acyl-activating enzyme (AAE) consensus motif; other site 765952006063 AMP binding site [chemical binding]; other site 765952006064 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 765952006065 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 765952006066 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 765952006067 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 765952006068 acyl-activating enzyme (AAE) consensus motif; other site 765952006069 AMP binding site [chemical binding]; other site 765952006070 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 765952006071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 765952006072 Coenzyme A binding pocket [chemical binding]; other site 765952006073 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 765952006074 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 765952006075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 765952006076 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 765952006077 putative substrate translocation pore; other site 765952006078 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 765952006079 integrase; Provisional; Region: PRK09692 765952006080 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 765952006081 active site 765952006082 Int/Topo IB signature motif; other site 765952006083 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 765952006084 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 765952006085 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 765952006086 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 765952006087 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 765952006088 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 765952006089 active site