-- dump date   	20140619_225301
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1116391000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1116391000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1116391000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391000004	Walker A motif; other site
1116391000005	ATP binding site [chemical binding]; other site
1116391000006	Walker B motif; other site
1116391000007	arginine finger; other site
1116391000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1116391000009	DnaA box-binding interface [nucleotide binding]; other site
1116391000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1116391000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1116391000012	putative DNA binding surface [nucleotide binding]; other site
1116391000013	dimer interface [polypeptide binding]; other site
1116391000014	beta-clamp/clamp loader binding surface; other site
1116391000015	beta-clamp/translesion DNA polymerase binding surface; other site
1116391000016	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1116391000017	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1116391000018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000019	ATP binding site [chemical binding]; other site
1116391000020	Mg2+ binding site [ion binding]; other site
1116391000021	G-X-G motif; other site
1116391000022	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1116391000023	anchoring element; other site
1116391000024	dimer interface [polypeptide binding]; other site
1116391000025	ATP binding site [chemical binding]; other site
1116391000026	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1116391000027	active site
1116391000028	putative metal-binding site [ion binding]; other site
1116391000029	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1116391000030	DNA gyrase subunit A; Validated; Region: PRK05560
1116391000031	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1116391000032	CAP-like domain; other site
1116391000033	active site
1116391000034	primary dimer interface [polypeptide binding]; other site
1116391000035	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391000036	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391000037	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391000038	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391000039	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391000040	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391000041	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1116391000042	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391000043	Zn2+ binding site [ion binding]; other site
1116391000044	Mg2+ binding site [ion binding]; other site
1116391000045	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1116391000046	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1116391000047	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1116391000048	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1116391000049	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1116391000050	active site
1116391000051	multimer interface [polypeptide binding]; other site
1116391000052	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1116391000053	predicted active site [active]
1116391000054	catalytic triad [active]
1116391000055	seryl-tRNA synthetase; Provisional; Region: PRK05431
1116391000056	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1116391000057	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1116391000058	dimer interface [polypeptide binding]; other site
1116391000059	active site
1116391000060	motif 1; other site
1116391000061	motif 2; other site
1116391000062	motif 3; other site
1116391000063	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1116391000064	Part of AAA domain; Region: AAA_19; pfam13245
1116391000065	Family description; Region: UvrD_C_2; pfam13538
1116391000066	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1116391000067	active site
1116391000068	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
1116391000069	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391000070	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391000071	DNA binding residues [nucleotide binding]
1116391000072	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1116391000073	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391000074	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1116391000075	nucleoside/Zn binding site; other site
1116391000076	dimer interface [polypeptide binding]; other site
1116391000077	catalytic motif [active]
1116391000078	PilZ domain; Region: PilZ; pfam07238
1116391000079	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1116391000080	amidase catalytic site [active]
1116391000081	Zn binding residues [ion binding]; other site
1116391000082	substrate binding site [chemical binding]; other site
1116391000083	GTP-binding protein YchF; Reviewed; Region: PRK09601
1116391000084	YchF GTPase; Region: YchF; cd01900
1116391000085	G1 box; other site
1116391000086	GTP/Mg2+ binding site [chemical binding]; other site
1116391000087	Switch I region; other site
1116391000088	G2 box; other site
1116391000089	Switch II region; other site
1116391000090	G3 box; other site
1116391000091	G4 box; other site
1116391000092	G5 box; other site
1116391000093	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1116391000094	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1116391000095	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1116391000096	RF-1 domain; Region: RF-1; pfam00472
1116391000097	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1116391000098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391000099	S-adenosylmethionine binding site [chemical binding]; other site
1116391000100	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
1116391000101	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1116391000102	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1116391000103	Predicted membrane protein [Function unknown]; Region: COG1971
1116391000104	Domain of unknown function DUF; Region: DUF204; pfam02659
1116391000105	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1116391000106	hypothetical protein; Provisional; Region: PRK13690
1116391000107	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1116391000108	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1116391000109	dimer interface [polypeptide binding]; other site
1116391000110	active site
1116391000111	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1116391000112	folate binding site [chemical binding]; other site
1116391000113	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391000114	active site
1116391000115	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1116391000116	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1116391000117	active site
1116391000118	homodimer interface [polypeptide binding]; other site
1116391000119	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
1116391000120	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1116391000121	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1116391000122	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1116391000123	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1116391000124	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1116391000125	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1116391000126	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1116391000127	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1116391000128	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1116391000129	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1116391000130	beta subunit interaction interface [polypeptide binding]; other site
1116391000131	Walker A motif; other site
1116391000132	ATP binding site [chemical binding]; other site
1116391000133	Walker B motif; other site
1116391000134	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1116391000135	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1116391000136	core domain interface [polypeptide binding]; other site
1116391000137	delta subunit interface [polypeptide binding]; other site
1116391000138	epsilon subunit interface [polypeptide binding]; other site
1116391000139	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1116391000140	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1116391000141	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1116391000142	alpha subunit interaction interface [polypeptide binding]; other site
1116391000143	Walker A motif; other site
1116391000144	ATP binding site [chemical binding]; other site
1116391000145	Walker B motif; other site
1116391000146	inhibitor binding site; inhibition site
1116391000147	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1116391000148	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1116391000149	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1116391000150	gamma subunit interface [polypeptide binding]; other site
1116391000151	epsilon subunit interface [polypeptide binding]; other site
1116391000152	LBP interface [polypeptide binding]; other site
1116391000153	NADH dehydrogenase subunit A; Validated; Region: PRK07756
1116391000154	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1116391000155	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1116391000156	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1116391000157	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
1116391000158	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1116391000159	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1116391000160	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1116391000161	4Fe-4S binding domain; Region: Fer4; pfam00037
1116391000162	4Fe-4S binding domain; Region: Fer4; cl02805
1116391000163	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1116391000164	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1116391000165	NADH dehydrogenase subunit J; Provisional; Region: PRK06439
1116391000166	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1116391000167	proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974
1116391000168	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1116391000169	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1116391000170	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1116391000171	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1116391000172	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1116391000173	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391000174	MarR family; Region: MarR; pfam01047
1116391000175	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1116391000176	active site
1116391000177	catalytic residues [active]
1116391000178	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1116391000179	S-layer homology domain; Region: SLH; pfam00395
1116391000180	S-layer homology domain; Region: SLH; pfam00395
1116391000181	S-layer homology domain; Region: SLH; pfam00395
1116391000182	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1116391000183	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1116391000184	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1116391000185	hinge; other site
1116391000186	active site
1116391000187	stage II sporulation protein D; Region: spore_II_D; TIGR02870
1116391000188	Stage II sporulation protein; Region: SpoIID; pfam08486
1116391000189	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391000190	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391000191	Stage III sporulation protein D; Region: SpoIIID; pfam12116
1116391000192	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1116391000193	MreB and similar proteins; Region: MreB_like; cd10225
1116391000194	nucleotide binding site [chemical binding]; other site
1116391000195	Mg binding site [ion binding]; other site
1116391000196	putative protofilament interaction site [polypeptide binding]; other site
1116391000197	RodZ interaction site [polypeptide binding]; other site
1116391000198	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1116391000199	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1116391000200	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1116391000201	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1116391000202	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1116391000203	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1116391000204	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1116391000205	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1116391000206	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1116391000207	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1116391000208	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1116391000209	active site
1116391000210	substrate binding site [chemical binding]; other site
1116391000211	metal binding site [ion binding]; metal-binding site
1116391000212	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1116391000213	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
1116391000214	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1116391000215	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1116391000216	Mg++ binding site [ion binding]; other site
1116391000217	putative catalytic motif [active]
1116391000218	substrate binding site [chemical binding]; other site
1116391000219	S-layer homology domain; Region: SLH; pfam00395
1116391000220	S-layer homology domain; Region: SLH; pfam00395
1116391000221	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1116391000222	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1116391000223	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1116391000224	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1116391000225	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1116391000226	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391000227	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391000228	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391000229	Sensor protein DegS; Region: DegS; pfam05384
1116391000230	Histidine kinase; Region: HisKA_3; pfam07730
1116391000231	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1116391000232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000233	ATP binding site [chemical binding]; other site
1116391000234	Mg2+ binding site [ion binding]; other site
1116391000235	G-X-G motif; other site
1116391000236	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391000237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391000238	active site
1116391000239	phosphorylation site [posttranslational modification]
1116391000240	intermolecular recognition site; other site
1116391000241	dimerization interface [polypeptide binding]; other site
1116391000242	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391000243	DNA binding residues [nucleotide binding]
1116391000244	dimerization interface [polypeptide binding]; other site
1116391000245	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391000246	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1116391000247	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391000248	ATP binding site [chemical binding]; other site
1116391000249	putative Mg++ binding site [ion binding]; other site
1116391000250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391000251	nucleotide binding region [chemical binding]; other site
1116391000252	ATP-binding site [chemical binding]; other site
1116391000253	comF family protein; Region: comF; TIGR00201
1116391000254	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391000255	active site
1116391000256	flagellar operon protein TIGR03826; Region: YvyF
1116391000257	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
1116391000258	FlgN protein; Region: FlgN; pfam05130
1116391000259	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
1116391000260	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1116391000261	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
1116391000262	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1116391000263	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1116391000264	flagellar assembly protein FliW; Provisional; Region: PRK13285
1116391000265	carbon storage regulator; Provisional; Region: PRK01712
1116391000266	flagellin; Provisional; Region: PRK12804
1116391000267	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1116391000268	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1116391000269	flagellin; Provisional; Region: PRK12804
1116391000270	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1116391000271	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1116391000272	FlaG protein; Region: FlaG; pfam03646
1116391000273	flagellar capping protein; Validated; Region: fliD; PRK07737
1116391000274	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1116391000275	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1116391000276	Flagellar protein FliS; Region: FliS; cl00654
1116391000277	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1116391000278	DNA-binding site [nucleotide binding]; DNA binding site
1116391000279	RNA-binding motif; other site
1116391000280	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1116391000281	30S subunit binding site; other site
1116391000282	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1116391000283	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1116391000284	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1116391000285	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1116391000286	nucleotide binding region [chemical binding]; other site
1116391000287	ATP-binding site [chemical binding]; other site
1116391000288	peptide chain release factor 2; Provisional; Region: PRK06746
1116391000289	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1116391000290	RF-1 domain; Region: RF-1; pfam00472
1116391000291	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391000292	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391000293	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391000294	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391000295	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1116391000296	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1116391000297	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1116391000298	molybdopterin cofactor binding site; other site
1116391000299	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1116391000300	molybdopterin cofactor binding site; other site
1116391000301	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1116391000302	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1116391000303	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1116391000304	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1116391000305	heterotetramer interface [polypeptide binding]; other site
1116391000306	active site pocket [active]
1116391000307	cleavage site
1116391000308	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1116391000309	nucleotide binding site [chemical binding]; other site
1116391000310	N-acetyl-L-glutamate binding site [chemical binding]; other site
1116391000311	acetylornithine aminotransferase; Provisional; Region: PRK02627
1116391000312	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391000313	inhibitor-cofactor binding pocket; inhibition site
1116391000314	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391000315	catalytic residue [active]
1116391000316	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1116391000317	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1116391000318	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1116391000319	argininosuccinate synthase; Provisional; Region: PRK13820
1116391000320	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1116391000321	ANP binding site [chemical binding]; other site
1116391000322	Substrate Binding Site II [chemical binding]; other site
1116391000323	Substrate Binding Site I [chemical binding]; other site
1116391000324	argininosuccinate lyase; Provisional; Region: PRK00855
1116391000325	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1116391000326	active sites [active]
1116391000327	tetramer interface [polypeptide binding]; other site
1116391000328	VanW like protein; Region: VanW; pfam04294
1116391000329	G5 domain; Region: G5; pfam07501
1116391000330	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1116391000331	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1116391000332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1116391000333	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1116391000334	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391000335	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391000336	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1116391000337	C-terminal peptidase (prc); Region: prc; TIGR00225
1116391000338	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1116391000339	protein binding site [polypeptide binding]; other site
1116391000340	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1116391000341	Catalytic dyad [active]
1116391000342	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1116391000343	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391000344	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1116391000345	flagellar motor protein MotS; Reviewed; Region: PRK06925
1116391000346	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1116391000347	ligand binding site [chemical binding]; other site
1116391000348	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1116391000349	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1116391000350	excinuclease ABC subunit B; Provisional; Region: PRK05298
1116391000351	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391000352	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391000353	nucleotide binding region [chemical binding]; other site
1116391000354	ATP-binding site [chemical binding]; other site
1116391000355	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1116391000356	UvrB/uvrC motif; Region: UVR; pfam02151
1116391000357	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391000358	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391000359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391000360	NAD(P) binding site [chemical binding]; other site
1116391000361	active site
1116391000362	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391000363	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1116391000364	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
1116391000365	hypothetical protein; Validated; Region: PRK07080
1116391000366	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391000367	FG-GAP repeat; Region: FG-GAP; pfam01839
1116391000368	Family description; Region: VCBS; pfam13517
1116391000369	FG-GAP repeat; Region: FG-GAP; pfam01839
1116391000370	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1116391000371	Peptidase family U32; Region: Peptidase_U32; pfam01136
1116391000372	Collagenase; Region: DUF3656; pfam12392
1116391000373	Peptidase family U32; Region: Peptidase_U32; pfam01136
1116391000374	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
1116391000375	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1116391000376	Walker A/P-loop; other site
1116391000377	ATP binding site [chemical binding]; other site
1116391000378	Q-loop/lid; other site
1116391000379	ABC transporter signature motif; other site
1116391000380	Walker B; other site
1116391000381	D-loop; other site
1116391000382	H-loop/switch region; other site
1116391000383	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
1116391000384	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1116391000385	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
1116391000386	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
1116391000387	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1116391000388	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391000389	motif II; other site
1116391000390	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1116391000391	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391000392	MarR family; Region: MarR; pfam01047
1116391000393	Coat F domain; Region: Coat_F; pfam07875
1116391000394	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1116391000395	PcrB family; Region: PcrB; pfam01884
1116391000396	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1116391000397	substrate binding site [chemical binding]; other site
1116391000398	putative active site [active]
1116391000399	dimer interface [polypeptide binding]; other site
1116391000400	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1116391000401	Part of AAA domain; Region: AAA_19; pfam13245
1116391000402	Family description; Region: UvrD_C_2; pfam13538
1116391000403	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1116391000404	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1116391000405	nucleotide binding pocket [chemical binding]; other site
1116391000406	K-X-D-G motif; other site
1116391000407	catalytic site [active]
1116391000408	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1116391000409	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1116391000410	Dimer interface [polypeptide binding]; other site
1116391000411	BRCT sequence motif; other site
1116391000412	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1116391000413	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1116391000414	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1116391000415	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1116391000416	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1116391000417	Walker A/P-loop; other site
1116391000418	ATP binding site [chemical binding]; other site
1116391000419	Q-loop/lid; other site
1116391000420	ABC transporter signature motif; other site
1116391000421	Walker B; other site
1116391000422	D-loop; other site
1116391000423	H-loop/switch region; other site
1116391000424	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1116391000425	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1116391000426	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1116391000427	Hpr binding site; other site
1116391000428	active site
1116391000429	homohexamer subunit interaction site [polypeptide binding]; other site
1116391000430	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1116391000431	pyrophosphatase PpaX; Provisional; Region: PRK13288
1116391000432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391000433	motif II; other site
1116391000434	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1116391000435	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1116391000436	trimer interface [polypeptide binding]; other site
1116391000437	active site
1116391000438	substrate binding site [chemical binding]; other site
1116391000439	CoA binding site [chemical binding]; other site
1116391000440	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1116391000441	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1116391000442	dimer interface [polypeptide binding]; other site
1116391000443	motif 1; other site
1116391000444	active site
1116391000445	motif 2; other site
1116391000446	motif 3; other site
1116391000447	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1116391000448	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1116391000449	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1116391000450	histidinol dehydrogenase; Region: hisD; TIGR00069
1116391000451	NAD binding site [chemical binding]; other site
1116391000452	dimerization interface [polypeptide binding]; other site
1116391000453	product binding site; other site
1116391000454	substrate binding site [chemical binding]; other site
1116391000455	zinc binding site [ion binding]; other site
1116391000456	catalytic residues [active]
1116391000457	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1116391000458	putative active site pocket [active]
1116391000459	4-fold oligomerization interface [polypeptide binding]; other site
1116391000460	metal binding residues [ion binding]; metal-binding site
1116391000461	3-fold/trimer interface [polypeptide binding]; other site
1116391000462	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1116391000463	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1116391000464	putative active site [active]
1116391000465	oxyanion strand; other site
1116391000466	catalytic triad [active]
1116391000467	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1116391000468	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1116391000469	substrate binding site [chemical binding]; other site
1116391000470	glutamase interaction surface [polypeptide binding]; other site
1116391000471	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1116391000472	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1116391000473	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1116391000474	metal binding site [ion binding]; metal-binding site
1116391000475	histidinol-phosphatase; Provisional; Region: PRK07328
1116391000476	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1116391000477	active site
1116391000478	dimer interface [polypeptide binding]; other site
1116391000479	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1116391000480	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1116391000481	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391000482	active site
1116391000483	TPR repeat; Region: TPR_11; pfam13414
1116391000484	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391000485	TPR motif; other site
1116391000486	binding surface
1116391000487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391000488	TPR motif; other site
1116391000489	binding surface
1116391000490	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1116391000491	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391000492	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391000493	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1116391000494	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1116391000495	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1116391000496	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1116391000497	active site
1116391000498	Zn binding site [ion binding]; other site
1116391000499	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
1116391000500	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000501	Interdomain contacts; other site
1116391000502	Cytokine receptor motif; other site
1116391000503	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1116391000504	active site
1116391000505	catalytic triad [active]
1116391000506	oxyanion hole [active]
1116391000507	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000508	Interdomain contacts; other site
1116391000509	S-layer homology domain; Region: SLH; pfam00395
1116391000510	S-layer homology domain; Region: SLH; pfam00395
1116391000511	S-layer homology domain; Region: SLH; pfam00395
1116391000512	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1116391000513	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1116391000514	nucleotide binding site [chemical binding]; other site
1116391000515	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1116391000516	AAA domain; Region: AAA_33; pfam13671
1116391000517	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1116391000518	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1116391000519	phosphate binding site [ion binding]; other site
1116391000520	putative substrate binding pocket [chemical binding]; other site
1116391000521	dimer interface [polypeptide binding]; other site
1116391000522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1116391000523	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1116391000524	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1116391000525	dimerization domain swap beta strand [polypeptide binding]; other site
1116391000526	regulatory protein interface [polypeptide binding]; other site
1116391000527	active site
1116391000528	regulatory phosphorylation site [posttranslational modification]; other site
1116391000529	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391000530	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391000531	Bacterial Ig-like domain; Region: Big_5; pfam13205
1116391000532	Clp protease; Region: CLP_protease; pfam00574
1116391000533	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1116391000534	oligomer interface [polypeptide binding]; other site
1116391000535	active site residues [active]
1116391000536	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1116391000537	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1116391000538	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1116391000539	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1116391000540	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1116391000541	Phosphoglycerate kinase; Region: PGK; pfam00162
1116391000542	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1116391000543	substrate binding site [chemical binding]; other site
1116391000544	hinge regions; other site
1116391000545	ADP binding site [chemical binding]; other site
1116391000546	catalytic site [active]
1116391000547	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1116391000548	triosephosphate isomerase; Provisional; Region: PRK14565
1116391000549	substrate binding site [chemical binding]; other site
1116391000550	dimer interface [polypeptide binding]; other site
1116391000551	catalytic triad [active]
1116391000552	phosphoglyceromutase; Provisional; Region: PRK05434
1116391000553	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1116391000554	enolase; Provisional; Region: eno; PRK00077
1116391000555	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1116391000556	dimer interface [polypeptide binding]; other site
1116391000557	metal binding site [ion binding]; metal-binding site
1116391000558	substrate binding pocket [chemical binding]; other site
1116391000559	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1116391000560	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1116391000561	Esterase/lipase [General function prediction only]; Region: COG1647
1116391000562	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1116391000563	ribonuclease R; Region: RNase_R; TIGR02063
1116391000564	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1116391000565	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1116391000566	RNB domain; Region: RNB; pfam00773
1116391000567	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1116391000568	RNA binding site [nucleotide binding]; other site
1116391000569	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1116391000570	SmpB-tmRNA interface; other site
1116391000571	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1116391000572	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1116391000573	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391000574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391000575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391000576	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1116391000577	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1116391000578	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391000579	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391000580	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1116391000581	putative hydrophobic ligand binding site [chemical binding]; other site
1116391000582	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1116391000583	putative transporter; Provisional; Region: PRK11021
1116391000584	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391000585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391000586	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391000587	dimerization interface [polypeptide binding]; other site
1116391000588	Imelysin; Region: Peptidase_M75; pfam09375
1116391000589	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1116391000590	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1116391000591	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1116391000592	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1116391000593	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1116391000594	putative active site [active]
1116391000595	catalytic triad [active]
1116391000596	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1116391000597	putative integrin binding motif; other site
1116391000598	PA/protease domain interface [polypeptide binding]; other site
1116391000599	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1116391000600	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1116391000601	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000602	Interdomain contacts; other site
1116391000603	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
1116391000604	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
1116391000605	putative active site [active]
1116391000606	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1116391000607	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1116391000608	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391000609	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391000610	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1116391000611	CAT RNA binding domain; Region: CAT_RBD; smart01061
1116391000612	PRD domain; Region: PRD; pfam00874
1116391000613	PRD domain; Region: PRD; pfam00874
1116391000614	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1116391000615	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1116391000616	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1116391000617	active site turn [active]
1116391000618	phosphorylation site [posttranslational modification]
1116391000619	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1116391000620	HPr interaction site; other site
1116391000621	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1116391000622	active site
1116391000623	phosphorylation site [posttranslational modification]
1116391000624	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1116391000625	dimerization domain swap beta strand [polypeptide binding]; other site
1116391000626	regulatory protein interface [polypeptide binding]; other site
1116391000627	active site
1116391000628	regulatory phosphorylation site [posttranslational modification]; other site
1116391000629	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1116391000630	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1116391000631	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1116391000632	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1116391000633	General stress protein [General function prediction only]; Region: GsiB; COG3729
1116391000634	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391000635	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391000636	metal binding site [ion binding]; metal-binding site
1116391000637	active site
1116391000638	I-site; other site
1116391000639	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1116391000640	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
1116391000641	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1116391000642	Hpr binding site; other site
1116391000643	active site
1116391000644	homohexamer subunit interaction site [polypeptide binding]; other site
1116391000645	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391000646	extended (e) SDRs; Region: SDR_e; cd08946
1116391000647	NAD(P) binding site [chemical binding]; other site
1116391000648	active site
1116391000649	substrate binding site [chemical binding]; other site
1116391000650	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1116391000651	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1116391000652	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391000653	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391000654	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1116391000655	active site
1116391000656	metal-dependent hydrolase; Provisional; Region: PRK13291
1116391000657	DinB superfamily; Region: DinB_2; pfam12867
1116391000658	short chain dehydrogenase; Provisional; Region: PRK05854
1116391000659	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1116391000660	putative NAD(P) binding site [chemical binding]; other site
1116391000661	active site
1116391000662	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1116391000663	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1116391000664	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1116391000665	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1116391000666	GIY-YIG motif/motif A; other site
1116391000667	active site
1116391000668	catalytic site [active]
1116391000669	putative DNA binding site [nucleotide binding]; other site
1116391000670	metal binding site [ion binding]; metal-binding site
1116391000671	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1116391000672	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1116391000673	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1116391000674	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1116391000675	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1116391000676	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1116391000677	dinuclear metal binding motif [ion binding]; other site
1116391000678	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391000679	Coenzyme A binding pocket [chemical binding]; other site
1116391000680	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391000681	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391000682	dimerization interface [polypeptide binding]; other site
1116391000683	Histidine kinase; Region: His_kinase; pfam06580
1116391000684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000685	ATP binding site [chemical binding]; other site
1116391000686	Mg2+ binding site [ion binding]; other site
1116391000687	G-X-G motif; other site
1116391000688	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391000689	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1116391000690	putative ligand binding site [chemical binding]; other site
1116391000691	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391000692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000693	dimer interface [polypeptide binding]; other site
1116391000694	conserved gate region; other site
1116391000695	ABC-ATPase subunit interface; other site
1116391000696	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391000697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000698	dimer interface [polypeptide binding]; other site
1116391000699	ABC-ATPase subunit interface; other site
1116391000700	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391000701	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391000702	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391000703	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391000704	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391000705	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1116391000706	putative ligand binding site [chemical binding]; other site
1116391000707	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391000708	dimerization interface [polypeptide binding]; other site
1116391000709	putative DNA binding site [nucleotide binding]; other site
1116391000710	putative Zn2+ binding site [ion binding]; other site
1116391000711	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1116391000712	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391000713	Walker A/P-loop; other site
1116391000714	ATP binding site [chemical binding]; other site
1116391000715	Q-loop/lid; other site
1116391000716	ABC transporter signature motif; other site
1116391000717	Walker B; other site
1116391000718	D-loop; other site
1116391000719	H-loop/switch region; other site
1116391000720	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391000721	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391000722	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391000723	Walker A/P-loop; other site
1116391000724	ATP binding site [chemical binding]; other site
1116391000725	Q-loop/lid; other site
1116391000726	ABC transporter signature motif; other site
1116391000727	Walker B; other site
1116391000728	D-loop; other site
1116391000729	H-loop/switch region; other site
1116391000730	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391000731	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1116391000732	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1116391000733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000734	dimer interface [polypeptide binding]; other site
1116391000735	conserved gate region; other site
1116391000736	putative PBP binding loops; other site
1116391000737	ABC-ATPase subunit interface; other site
1116391000738	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391000739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000740	dimer interface [polypeptide binding]; other site
1116391000741	conserved gate region; other site
1116391000742	putative PBP binding loops; other site
1116391000743	ABC-ATPase subunit interface; other site
1116391000744	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1116391000745	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1116391000746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391000747	S-adenosylmethionine binding site [chemical binding]; other site
1116391000748	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
1116391000749	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1116391000750	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1116391000751	active site
1116391000752	ATP binding site [chemical binding]; other site
1116391000753	substrate binding site [chemical binding]; other site
1116391000754	activation loop (A-loop); other site
1116391000755	S-layer homology domain; Region: SLH; pfam00395
1116391000756	S-layer homology domain; Region: SLH; pfam00395
1116391000757	CAAX protease self-immunity; Region: Abi; pfam02517
1116391000758	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1116391000759	Predicted integral membrane protein [Function unknown]; Region: COG5658
1116391000760	SdpI/YhfL protein family; Region: SdpI; pfam13630
1116391000761	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391000762	putative DNA binding site [nucleotide binding]; other site
1116391000763	putative Zn2+ binding site [ion binding]; other site
1116391000764	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391000765	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391000766	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391000767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391000768	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391000769	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391000770	active site
1116391000771	catalytic tetrad [active]
1116391000772	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391000773	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391000774	WHG domain; Region: WHG; pfam13305
1116391000775	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1116391000776	Sulfatase; Region: Sulfatase; pfam00884
1116391000777	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1116391000778	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1116391000779	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1116391000780	active site
1116391000781	P-loop; other site
1116391000782	phosphorylation site [posttranslational modification]
1116391000783	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
1116391000784	HTH domain; Region: HTH_11; cl17392
1116391000785	HTH domain; Region: HTH_11; pfam08279
1116391000786	PRD domain; Region: PRD; pfam00874
1116391000787	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1116391000788	active site
1116391000789	P-loop; other site
1116391000790	phosphorylation site [posttranslational modification]
1116391000791	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1116391000792	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1116391000793	active site
1116391000794	phosphorylation site [posttranslational modification]
1116391000795	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1116391000796	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1116391000797	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1116391000798	deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353
1116391000799	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391000800	Zn2+ binding site [ion binding]; other site
1116391000801	Mg2+ binding site [ion binding]; other site
1116391000802	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1116391000803	transglutaminase; Provisional; Region: tgl; PRK03187
1116391000804	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391000805	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1116391000806	active site
1116391000807	metal binding site [ion binding]; metal-binding site
1116391000808	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1116391000809	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391000810	DNA-binding site [nucleotide binding]; DNA binding site
1116391000811	FCD domain; Region: FCD; pfam07729
1116391000812	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391000813	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391000814	Walker A/P-loop; other site
1116391000815	ATP binding site [chemical binding]; other site
1116391000816	Q-loop/lid; other site
1116391000817	ABC transporter signature motif; other site
1116391000818	Walker B; other site
1116391000819	D-loop; other site
1116391000820	H-loop/switch region; other site
1116391000821	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391000822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000823	putative PBP binding loops; other site
1116391000824	dimer interface [polypeptide binding]; other site
1116391000825	ABC-ATPase subunit interface; other site
1116391000826	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1116391000827	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391000828	membrane-bound complex binding site; other site
1116391000829	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1116391000830	nudix motif; other site
1116391000831	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1116391000832	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000833	Interdomain contacts; other site
1116391000834	Cytokine receptor motif; other site
1116391000835	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391000836	putative metal binding site [ion binding]; other site
1116391000837	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000838	Interdomain contacts; other site
1116391000839	Cytokine receptor motif; other site
1116391000840	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000841	Interdomain contacts; other site
1116391000842	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391000843	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391000844	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391000845	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391000846	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391000847	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391000848	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391000849	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000850	Interdomain contacts; other site
1116391000851	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391000852	Interdomain contacts; other site
1116391000853	Cytokine receptor motif; other site
1116391000854	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1116391000855	catalytic core [active]
1116391000856	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1116391000857	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391000858	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391000859	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1116391000860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391000861	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1116391000862	putative active site [active]
1116391000863	heme pocket [chemical binding]; other site
1116391000864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391000865	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1116391000866	putative active site [active]
1116391000867	heme pocket [chemical binding]; other site
1116391000868	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1116391000869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391000870	heme pocket [chemical binding]; other site
1116391000871	putative active site [active]
1116391000872	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391000873	putative active site [active]
1116391000874	heme pocket [chemical binding]; other site
1116391000875	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391000876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391000877	putative active site [active]
1116391000878	heme pocket [chemical binding]; other site
1116391000879	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391000880	dimer interface [polypeptide binding]; other site
1116391000881	phosphorylation site [posttranslational modification]
1116391000882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000883	ATP binding site [chemical binding]; other site
1116391000884	Mg2+ binding site [ion binding]; other site
1116391000885	G-X-G motif; other site
1116391000886	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1116391000887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391000888	active site
1116391000889	phosphorylation site [posttranslational modification]
1116391000890	intermolecular recognition site; other site
1116391000891	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1116391000892	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1116391000893	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391000894	YhfH-like protein; Region: YhfH; pfam14149
1116391000895	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391000896	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391000897	dimer interface [polypeptide binding]; other site
1116391000898	phosphorylation site [posttranslational modification]
1116391000899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000900	ATP binding site [chemical binding]; other site
1116391000901	Mg2+ binding site [ion binding]; other site
1116391000902	G-X-G motif; other site
1116391000903	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391000904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391000905	active site
1116391000906	phosphorylation site [posttranslational modification]
1116391000907	intermolecular recognition site; other site
1116391000908	dimerization interface [polypeptide binding]; other site
1116391000909	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391000910	Histidine kinase; Region: HisKA_3; pfam07730
1116391000911	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1116391000912	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391000913	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391000914	active site
1116391000915	phosphorylation site [posttranslational modification]
1116391000916	intermolecular recognition site; other site
1116391000917	dimerization interface [polypeptide binding]; other site
1116391000918	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391000919	DNA binding residues [nucleotide binding]
1116391000920	dimerization interface [polypeptide binding]; other site
1116391000921	Predicted membrane protein [Function unknown]; Region: COG4818
1116391000922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391000923	dimer interface [polypeptide binding]; other site
1116391000924	phosphorylation site [posttranslational modification]
1116391000925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000926	ATP binding site [chemical binding]; other site
1116391000927	Mg2+ binding site [ion binding]; other site
1116391000928	G-X-G motif; other site
1116391000929	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1116391000930	dimer interface [polypeptide binding]; other site
1116391000931	FMN binding site [chemical binding]; other site
1116391000932	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391000933	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391000934	dimerization interface [polypeptide binding]; other site
1116391000935	Histidine kinase; Region: His_kinase; pfam06580
1116391000936	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391000937	ATP binding site [chemical binding]; other site
1116391000938	Mg2+ binding site [ion binding]; other site
1116391000939	G-X-G motif; other site
1116391000940	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391000941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391000942	active site
1116391000943	phosphorylation site [posttranslational modification]
1116391000944	intermolecular recognition site; other site
1116391000945	dimerization interface [polypeptide binding]; other site
1116391000946	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391000947	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391000948	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391000949	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391000950	EamA-like transporter family; Region: EamA; pfam00892
1116391000951	EamA-like transporter family; Region: EamA; pfam00892
1116391000952	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391000953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391000954	putative substrate translocation pore; other site
1116391000955	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391000956	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391000957	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1116391000958	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391000959	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391000960	Coenzyme A binding pocket [chemical binding]; other site
1116391000961	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
1116391000962	Phage Tail Collar Domain; Region: Collar; pfam07484
1116391000963	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1116391000964	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
1116391000965	Phage Tail Collar Domain; Region: Collar; pfam07484
1116391000966	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
1116391000967	Phage Tail Collar Domain; Region: Collar; pfam07484
1116391000968	Domain of unknown function DUF11; Region: DUF11; pfam01345
1116391000969	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1116391000970	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391000971	S-layer homology domain; Region: SLH; pfam00395
1116391000972	S-layer homology domain; Region: SLH; pfam00395
1116391000973	S-layer homology domain; Region: SLH; pfam00395
1116391000974	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391000975	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391000976	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1116391000977	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
1116391000978	putative active site [active]
1116391000979	putative FMN binding site [chemical binding]; other site
1116391000980	putative substrate binding site [chemical binding]; other site
1116391000981	putative catalytic residue [active]
1116391000982	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391000983	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391000984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391000985	S-adenosylmethionine binding site [chemical binding]; other site
1116391000986	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1116391000987	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391000988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000989	dimer interface [polypeptide binding]; other site
1116391000990	conserved gate region; other site
1116391000991	putative PBP binding loops; other site
1116391000992	ABC-ATPase subunit interface; other site
1116391000993	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391000994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391000995	dimer interface [polypeptide binding]; other site
1116391000996	conserved gate region; other site
1116391000997	ABC-ATPase subunit interface; other site
1116391000998	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391000999	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391001000	putative alpha-glucosidase; Provisional; Region: PRK10658
1116391001001	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1116391001002	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1116391001003	active site
1116391001004	homotrimer interface [polypeptide binding]; other site
1116391001005	catalytic site [active]
1116391001006	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1116391001007	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391001008	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391001009	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391001010	S-layer homology domain; Region: SLH; pfam00395
1116391001011	S-layer homology domain; Region: SLH; pfam00395
1116391001012	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
1116391001013	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1116391001014	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1116391001015	metal ion-dependent adhesion site (MIDAS); other site
1116391001016	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1116391001017	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1116391001018	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1116391001019	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1116391001020	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1116391001021	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391001022	active site
1116391001023	substrate binding site [chemical binding]; other site
1116391001024	ATP binding site [chemical binding]; other site
1116391001025	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1116391001026	AAA domain; Region: AAA_31; pfam13614
1116391001027	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1116391001028	Protein of unknown function (DUF1162); Region: DUF1162; pfam06650
1116391001029	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1116391001030	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1116391001031	Walker A motif; other site
1116391001032	ATP binding site [chemical binding]; other site
1116391001033	Walker B motif; other site
1116391001034	S-layer homology domain; Region: SLH; pfam00395
1116391001035	S-layer homology domain; Region: SLH; pfam00395
1116391001036	putative catalytic domain of glycoside hydrolase family 119 (GH119); Region: GH119_BcIgtZ-like; cd11663
1116391001037	putative active site [active]
1116391001038	catalytic site [active]
1116391001039	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391001040	Interdomain contacts; other site
1116391001041	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
1116391001042	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
1116391001043	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
1116391001044	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1116391001045	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
1116391001046	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1116391001047	DctM-like transporters; Region: DctM; pfam06808
1116391001048	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1116391001049	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1116391001050	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1116391001051	Cache domain; Region: Cache_1; pfam02743
1116391001052	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391001053	dimerization interface [polypeptide binding]; other site
1116391001054	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391001055	Histidine kinase; Region: His_kinase; pfam06580
1116391001056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391001057	ATP binding site [chemical binding]; other site
1116391001058	Mg2+ binding site [ion binding]; other site
1116391001059	G-X-G motif; other site
1116391001060	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391001061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001062	active site
1116391001063	phosphorylation site [posttranslational modification]
1116391001064	intermolecular recognition site; other site
1116391001065	dimerization interface [polypeptide binding]; other site
1116391001066	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391001067	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391001068	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391001069	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1116391001070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001071	active site
1116391001072	phosphorylation site [posttranslational modification]
1116391001073	intermolecular recognition site; other site
1116391001074	dimerization interface [polypeptide binding]; other site
1116391001075	B12 binding domain; Region: B12-binding_2; pfam02607
1116391001076	B12 binding domain; Region: B12-binding; pfam02310
1116391001077	B12 binding site [chemical binding]; other site
1116391001078	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391001079	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391001080	dimer interface [polypeptide binding]; other site
1116391001081	phosphorylation site [posttranslational modification]
1116391001082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391001083	ATP binding site [chemical binding]; other site
1116391001084	Mg2+ binding site [ion binding]; other site
1116391001085	G-X-G motif; other site
1116391001086	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391001087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001088	active site
1116391001089	phosphorylation site [posttranslational modification]
1116391001090	intermolecular recognition site; other site
1116391001091	dimerization interface [polypeptide binding]; other site
1116391001092	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1116391001093	putative binding surface; other site
1116391001094	active site
1116391001095	Pectate lyase; Region: Pectate_lyase; pfam03211
1116391001096	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1116391001097	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1116391001098	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391001099	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1116391001100	Protein of unknown function; Region: DUF3658; pfam12395
1116391001101	Leucine rich repeat; Region: LRR_8; pfam13855
1116391001102	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1116391001103	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391001104	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391001105	DNA binding residues [nucleotide binding]
1116391001106	SnoaL-like domain; Region: SnoaL_2; pfam12680
1116391001107	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1116391001108	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391001109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391001110	Coenzyme A binding pocket [chemical binding]; other site
1116391001111	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1116391001112	dimer interface [polypeptide binding]; other site
1116391001113	FMN binding site [chemical binding]; other site
1116391001114	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1116391001115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1116391001116	P-loop; other site
1116391001117	Magnesium ion binding site [ion binding]; other site
1116391001118	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1116391001119	Magnesium ion binding site [ion binding]; other site
1116391001120	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1116391001121	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1116391001122	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
1116391001123	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
1116391001124	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
1116391001125	active site
1116391001126	RNA/DNA hybrid binding site [nucleotide binding]; other site
1116391001127	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1116391001128	putative hydrolase; Provisional; Region: PRK11460
1116391001129	Predicted esterase [General function prediction only]; Region: COG0400
1116391001130	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1116391001131	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391001132	Zn binding site [ion binding]; other site
1116391001133	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1116391001134	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391001135	Zn binding site [ion binding]; other site
1116391001136	DoxX; Region: DoxX; pfam07681
1116391001137	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391001138	MarR family; Region: MarR; pfam01047
1116391001139	MarR family; Region: MarR_2; cl17246
1116391001140	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391001141	HTH domain; Region: HTH_11; pfam08279
1116391001142	WYL domain; Region: WYL; pfam13280
1116391001143	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1116391001144	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1116391001145	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1116391001146	Na2 binding site [ion binding]; other site
1116391001147	putative substrate binding site 1 [chemical binding]; other site
1116391001148	Na binding site 1 [ion binding]; other site
1116391001149	putative substrate binding site 2 [chemical binding]; other site
1116391001150	PAS fold; Region: PAS_4; pfam08448
1116391001151	PAS domain S-box; Region: sensory_box; TIGR00229
1116391001152	PAS domain; Region: PAS; smart00091
1116391001153	putative active site [active]
1116391001154	heme pocket [chemical binding]; other site
1116391001155	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391001156	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391001157	metal binding site [ion binding]; metal-binding site
1116391001158	active site
1116391001159	I-site; other site
1116391001160	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391001161	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1116391001162	ThiC-associated domain; Region: ThiC-associated; pfam13667
1116391001163	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1116391001164	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
1116391001165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391001166	Walker A/P-loop; other site
1116391001167	ATP binding site [chemical binding]; other site
1116391001168	Q-loop/lid; other site
1116391001169	ABC transporter signature motif; other site
1116391001170	Walker B; other site
1116391001171	D-loop; other site
1116391001172	H-loop/switch region; other site
1116391001173	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1116391001174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391001175	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391001176	dimerization interface [polypeptide binding]; other site
1116391001177	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391001178	dimer interface [polypeptide binding]; other site
1116391001179	phosphorylation site [posttranslational modification]
1116391001180	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391001181	ATP binding site [chemical binding]; other site
1116391001182	Mg2+ binding site [ion binding]; other site
1116391001183	G-X-G motif; other site
1116391001184	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391001185	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001186	active site
1116391001187	phosphorylation site [posttranslational modification]
1116391001188	intermolecular recognition site; other site
1116391001189	dimerization interface [polypeptide binding]; other site
1116391001190	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391001191	DNA binding site [nucleotide binding]
1116391001192	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391001193	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391001194	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1116391001195	pyruvate kinase; Provisional; Region: PRK05826
1116391001196	domain interfaces; other site
1116391001197	active site
1116391001198	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1116391001199	seryl-tRNA synthetase; Provisional; Region: PRK05431
1116391001200	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1116391001201	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1116391001202	motif 1; other site
1116391001203	dimer interface [polypeptide binding]; other site
1116391001204	active site
1116391001205	motif 2; other site
1116391001206	motif 3; other site
1116391001207	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391001208	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1116391001209	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391001210	Walker A/P-loop; other site
1116391001211	ATP binding site [chemical binding]; other site
1116391001212	Q-loop/lid; other site
1116391001213	ABC transporter signature motif; other site
1116391001214	Walker B; other site
1116391001215	D-loop; other site
1116391001216	H-loop/switch region; other site
1116391001217	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391001218	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391001219	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391001220	Walker A/P-loop; other site
1116391001221	ATP binding site [chemical binding]; other site
1116391001222	Q-loop/lid; other site
1116391001223	ABC transporter signature motif; other site
1116391001224	Walker B; other site
1116391001225	D-loop; other site
1116391001226	H-loop/switch region; other site
1116391001227	Thiamine pyrophosphokinase; Region: TPK; cd07995
1116391001228	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1116391001229	active site
1116391001230	dimerization interface [polypeptide binding]; other site
1116391001231	thiamine binding site [chemical binding]; other site
1116391001232	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1116391001233	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1116391001234	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1116391001235	Virulence factor; Region: Virulence_fact; pfam13769
1116391001236	HEAT repeats; Region: HEAT_2; pfam13646
1116391001237	HEAT repeat; Region: HEAT; pfam02985
1116391001238	HEAT repeats; Region: HEAT_2; pfam13646
1116391001239	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1116391001240	DinB superfamily; Region: DinB_2; pfam12867
1116391001241	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1116391001242	Guanylate kinase; Region: Guanylate_kin; pfam00625
1116391001243	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1116391001244	active site
1116391001245	helicase 45; Provisional; Region: PTZ00424
1116391001246	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1116391001247	ATP binding site [chemical binding]; other site
1116391001248	Mg++ binding site [ion binding]; other site
1116391001249	motif III; other site
1116391001250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391001251	nucleotide binding region [chemical binding]; other site
1116391001252	ATP-binding site [chemical binding]; other site
1116391001253	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1116391001254	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1116391001255	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1116391001256	Cytochrome c; Region: Cytochrom_C; cl11414
1116391001257	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1116391001258	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1116391001259	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1116391001260	D-pathway; other site
1116391001261	Putative ubiquinol binding site [chemical binding]; other site
1116391001262	Low-spin heme (heme b) binding site [chemical binding]; other site
1116391001263	Putative water exit pathway; other site
1116391001264	Binuclear center (heme o3/CuB) [ion binding]; other site
1116391001265	K-pathway; other site
1116391001266	Putative proton exit pathway; other site
1116391001267	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1116391001268	Subunit I/III interface [polypeptide binding]; other site
1116391001269	Subunit III/IV interface [polypeptide binding]; other site
1116391001270	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
1116391001271	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
1116391001272	Protein of unknown function (DUF420); Region: DUF420; pfam04238
1116391001273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391001274	Bacterial SH3 domain; Region: SH3_3; pfam08239
1116391001275	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391001276	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391001277	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1116391001278	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391001279	catalytic residues [active]
1116391001280	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1116391001281	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1116391001282	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1116391001283	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1116391001284	putative NAD(P) binding site [chemical binding]; other site
1116391001285	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391001286	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391001287	dimerization interface [polypeptide binding]; other site
1116391001288	putative DNA binding site [nucleotide binding]; other site
1116391001289	putative Zn2+ binding site [ion binding]; other site
1116391001290	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1116391001291	MOSC domain; Region: MOSC; pfam03473
1116391001292	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
1116391001293	active site
1116391001294	catalytic residues [active]
1116391001295	metal binding site [ion binding]; metal-binding site
1116391001296	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1116391001297	putative active site [active]
1116391001298	nucleotide binding site [chemical binding]; other site
1116391001299	nudix motif; other site
1116391001300	putative metal binding site [ion binding]; other site
1116391001301	S-layer homology domain; Region: SLH; pfam00395
1116391001302	S-layer homology domain; Region: SLH; pfam00395
1116391001303	S-layer homology domain; Region: SLH; pfam00395
1116391001304	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1116391001305	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1116391001306	S-layer homology domain; Region: SLH; pfam00395
1116391001307	S-layer homology domain; Region: SLH; pfam00395
1116391001308	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1116391001309	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
1116391001310	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1116391001311	putative acyl-acceptor binding pocket; other site
1116391001312	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391001313	acyl-activating enzyme (AAE) consensus motif; other site
1116391001314	AMP binding site [chemical binding]; other site
1116391001315	active site
1116391001316	CoA binding site [chemical binding]; other site
1116391001317	HI0933-like protein; Region: HI0933_like; pfam03486
1116391001318	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391001319	Site-specific recombinase; Region: SpecificRecomb; cl15411
1116391001320	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1116391001321	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391001322	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391001323	dimerization interface [polypeptide binding]; other site
1116391001324	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391001325	dimer interface [polypeptide binding]; other site
1116391001326	putative CheW interface [polypeptide binding]; other site
1116391001327	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1116391001328	Domain of unknown function DUF21; Region: DUF21; pfam01595
1116391001329	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1116391001330	Transporter associated domain; Region: CorC_HlyC; smart01091
1116391001331	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1116391001332	Cation efflux family; Region: Cation_efflux; pfam01545
1116391001333	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
1116391001334	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
1116391001335	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1116391001336	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1116391001337	homodimer interface [polypeptide binding]; other site
1116391001338	NAD binding pocket [chemical binding]; other site
1116391001339	ATP binding pocket [chemical binding]; other site
1116391001340	Mg binding site [ion binding]; other site
1116391001341	active-site loop [active]
1116391001342	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1116391001343	dimanganese center [ion binding]; other site
1116391001344	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391001345	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1116391001346	inhibitor-cofactor binding pocket; inhibition site
1116391001347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391001348	catalytic residue [active]
1116391001349	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1116391001350	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1116391001351	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391001352	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391001353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391001354	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391001355	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1116391001356	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1116391001357	minor groove reading motif; other site
1116391001358	helix-hairpin-helix signature motif; other site
1116391001359	substrate binding pocket [chemical binding]; other site
1116391001360	active site
1116391001361	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1116391001362	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1116391001363	DNA binding and oxoG recognition site [nucleotide binding]
1116391001364	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391001365	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391001366	ligand binding site [chemical binding]; other site
1116391001367	flexible hinge region; other site
1116391001368	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1116391001369	non-specific DNA interactions [nucleotide binding]; other site
1116391001370	DNA binding site [nucleotide binding]
1116391001371	sequence specific DNA binding site [nucleotide binding]; other site
1116391001372	putative cAMP binding site [chemical binding]; other site
1116391001373	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1116391001374	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1116391001375	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1116391001376	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1116391001377	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1116391001378	active site
1116391001379	catalytic residues [active]
1116391001380	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1116391001381	S-layer homology domain; Region: SLH; pfam00395
1116391001382	S-layer homology domain; Region: SLH; pfam00395
1116391001383	putative acetyltransferase; Provisional; Region: PRK03624
1116391001384	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391001385	Coenzyme A binding pocket [chemical binding]; other site
1116391001386	Protein of unknown function (DUF402); Region: DUF402; cl00979
1116391001387	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1116391001388	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1116391001389	Catalytic site [active]
1116391001390	epoxyqueuosine reductase; Region: TIGR00276
1116391001391	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1116391001392	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
1116391001393	protein binding surface [polypeptide binding]; other site
1116391001394	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1116391001395	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1116391001396	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1116391001397	DNA binding site [nucleotide binding]
1116391001398	active site
1116391001399	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1116391001400	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391001401	Zn2+ binding site [ion binding]; other site
1116391001402	Mg2+ binding site [ion binding]; other site
1116391001403	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1116391001404	homodecamer interface [polypeptide binding]; other site
1116391001405	GTP cyclohydrolase I; Provisional; Region: PLN03044
1116391001406	active site
1116391001407	putative catalytic site residues [active]
1116391001408	zinc binding site [ion binding]; other site
1116391001409	GTP-CH-I/GFRP interaction surface; other site
1116391001410	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391001411	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1116391001412	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1116391001413	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1116391001414	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391001415	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1116391001416	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1116391001417	Bacterial transcriptional regulator; Region: IclR; pfam01614
1116391001418	Putative amidase domain; Region: Amidase_6; pfam12671
1116391001419	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1116391001420	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1116391001421	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1116391001422	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391001423	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391001424	Transposase; Region: HTH_Tnp_1; cl17663
1116391001425	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391001426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391001427	HTH-like domain; Region: HTH_21; pfam13276
1116391001428	Integrase core domain; Region: rve; pfam00665
1116391001429	Integrase core domain; Region: rve_2; pfam13333
1116391001430	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1116391001431	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1116391001432	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1116391001433	NAD binding site [chemical binding]; other site
1116391001434	homotetramer interface [polypeptide binding]; other site
1116391001435	homodimer interface [polypeptide binding]; other site
1116391001436	substrate binding site [chemical binding]; other site
1116391001437	active site
1116391001438	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1116391001439	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1116391001440	active site
1116391001441	dimerization interface [polypeptide binding]; other site
1116391001442	AAA domain; Region: AAA_26; pfam13500
1116391001443	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1116391001444	ADP binding site [chemical binding]; other site
1116391001445	biotin synthase; Validated; Region: PRK06256
1116391001446	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391001447	FeS/SAM binding site; other site
1116391001448	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1116391001449	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1116391001450	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1116391001451	substrate-cofactor binding pocket; other site
1116391001452	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391001453	catalytic residue [active]
1116391001454	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391001455	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1116391001456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391001457	S-adenosylmethionine binding site [chemical binding]; other site
1116391001458	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481
1116391001459	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1116391001460	NADP binding site [chemical binding]; other site
1116391001461	homodimer interface [polypeptide binding]; other site
1116391001462	active site
1116391001463	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1116391001464	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391001465	substrate binding site [chemical binding]; other site
1116391001466	ATP binding site [chemical binding]; other site
1116391001467	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1116391001468	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1116391001469	active site
1116391001470	intersubunit interface [polypeptide binding]; other site
1116391001471	catalytic residue [active]
1116391001472	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1116391001473	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1116391001474	[2Fe-2S] cluster binding site [ion binding]; other site
1116391001475	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1116391001476	hydrophobic ligand binding site; other site
1116391001477	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
1116391001478	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1116391001479	active site
1116391001480	dimer interface [polypeptide binding]; other site
1116391001481	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1116391001482	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1116391001483	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
1116391001484	active site
1116391001485	FMN binding site [chemical binding]; other site
1116391001486	substrate binding site [chemical binding]; other site
1116391001487	3Fe-4S cluster binding site [ion binding]; other site
1116391001488	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
1116391001489	domain_subunit interface; other site
1116391001490	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1116391001491	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391001492	inhibitor-cofactor binding pocket; inhibition site
1116391001493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391001494	catalytic residue [active]
1116391001495	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1116391001496	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1116391001497	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1116391001498	ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267
1116391001499	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1116391001500	Walker A/P-loop; other site
1116391001501	ATP binding site [chemical binding]; other site
1116391001502	Q-loop/lid; other site
1116391001503	ABC transporter signature motif; other site
1116391001504	Walker B; other site
1116391001505	D-loop; other site
1116391001506	H-loop/switch region; other site
1116391001507	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1116391001508	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391001509	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391001510	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391001511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001512	active site
1116391001513	phosphorylation site [posttranslational modification]
1116391001514	intermolecular recognition site; other site
1116391001515	dimerization interface [polypeptide binding]; other site
1116391001516	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391001517	DNA binding residues [nucleotide binding]
1116391001518	dimerization interface [polypeptide binding]; other site
1116391001519	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1116391001520	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1116391001521	catalytic triad [active]
1116391001522	glycerate dehydrogenase; Provisional; Region: PRK06487
1116391001523	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1116391001524	putative ligand binding site [chemical binding]; other site
1116391001525	putative NAD binding site [chemical binding]; other site
1116391001526	catalytic site [active]
1116391001527	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1116391001528	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391001529	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1116391001530	NodB motif; other site
1116391001531	active site
1116391001532	catalytic site [active]
1116391001533	Zn binding site [ion binding]; other site
1116391001534	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391001535	MoxR-like ATPases [General function prediction only]; Region: COG0714
1116391001536	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391001537	Walker A motif; other site
1116391001538	ATP binding site [chemical binding]; other site
1116391001539	Walker B motif; other site
1116391001540	arginine finger; other site
1116391001541	Protein of unknown function DUF58; Region: DUF58; pfam01882
1116391001542	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1116391001543	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1116391001544	GMP synthase; Reviewed; Region: guaA; PRK00074
1116391001545	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1116391001546	AMP/PPi binding site [chemical binding]; other site
1116391001547	candidate oxyanion hole; other site
1116391001548	catalytic triad [active]
1116391001549	potential glutamine specificity residues [chemical binding]; other site
1116391001550	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1116391001551	ATP Binding subdomain [chemical binding]; other site
1116391001552	Ligand Binding sites [chemical binding]; other site
1116391001553	Dimerization subdomain; other site
1116391001554	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1116391001555	2-isopropylmalate synthase; Validated; Region: PRK00915
1116391001556	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1116391001557	active site
1116391001558	catalytic residues [active]
1116391001559	metal binding site [ion binding]; metal-binding site
1116391001560	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1116391001561	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1116391001562	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1116391001563	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391001564	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391001565	ABC transporter; Region: ABC_tran_2; pfam12848
1116391001566	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391001567	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1116391001568	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1116391001569	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1116391001570	trimer interface [polypeptide binding]; other site
1116391001571	dimer interface [polypeptide binding]; other site
1116391001572	putative active site [active]
1116391001573	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1116391001574	MPT binding site; other site
1116391001575	trimer interface [polypeptide binding]; other site
1116391001576	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1116391001577	putative MPT binding site; other site
1116391001578	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1116391001579	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1116391001580	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1116391001581	oligomerisation interface [polypeptide binding]; other site
1116391001582	mobile loop; other site
1116391001583	roof hairpin; other site
1116391001584	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1116391001585	hinge regions; other site
1116391001586	stacking interactions; other site
1116391001587	SNF2 Helicase protein; Region: DUF3670; pfam12419
1116391001588	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1116391001589	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391001590	ATP binding site [chemical binding]; other site
1116391001591	putative Mg++ binding site [ion binding]; other site
1116391001592	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391001593	nucleotide binding region [chemical binding]; other site
1116391001594	ATP-binding site [chemical binding]; other site
1116391001595	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1116391001596	S-layer homology domain; Region: SLH; pfam00395
1116391001597	S-layer homology domain; Region: SLH; pfam00395
1116391001598	S-layer homology domain; Region: SLH; pfam00395
1116391001599	S-layer homology domain; Region: SLH; pfam00395
1116391001600	S-layer homology domain; Region: SLH; pfam00395
1116391001601	S-layer homology domain; Region: SLH; pfam00395
1116391001602	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
1116391001603	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1116391001604	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1116391001605	substrate binding site; other site
1116391001606	tetramer interface; other site
1116391001607	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1116391001608	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1116391001609	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1116391001610	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1116391001611	Walker A/P-loop; other site
1116391001612	ATP binding site [chemical binding]; other site
1116391001613	Q-loop/lid; other site
1116391001614	ABC transporter signature motif; other site
1116391001615	Walker B; other site
1116391001616	D-loop; other site
1116391001617	H-loop/switch region; other site
1116391001618	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1116391001619	putative carbohydrate binding site [chemical binding]; other site
1116391001620	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391001621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391001622	S-adenosylmethionine binding site [chemical binding]; other site
1116391001623	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391001624	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391001625	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391001626	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1116391001627	active site
1116391001628	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391001629	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391001630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391001631	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391001632	NAD(P) binding site [chemical binding]; other site
1116391001633	active site
1116391001634	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391001635	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1116391001636	Probable Catalytic site; other site
1116391001637	metal-binding site
1116391001638	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1116391001639	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1116391001640	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1116391001641	NAD binding site [chemical binding]; other site
1116391001642	substrate binding site [chemical binding]; other site
1116391001643	homodimer interface [polypeptide binding]; other site
1116391001644	active site
1116391001645	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1116391001646	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1116391001647	NADP binding site [chemical binding]; other site
1116391001648	active site
1116391001649	putative substrate binding site [chemical binding]; other site
1116391001650	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1116391001651	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1116391001652	Probable Catalytic site; other site
1116391001653	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391001654	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1116391001655	Probable Catalytic site; other site
1116391001656	metal-binding site
1116391001657	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1116391001658	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391001659	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1116391001660	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1116391001661	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1116391001662	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1116391001663	Ligand binding site; other site
1116391001664	Putative Catalytic site; other site
1116391001665	DXD motif; other site
1116391001666	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
1116391001667	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
1116391001668	alanine racemase; Reviewed; Region: alr; PRK00053
1116391001669	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1116391001670	active site
1116391001671	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1116391001672	dimer interface [polypeptide binding]; other site
1116391001673	substrate binding site [chemical binding]; other site
1116391001674	catalytic residues [active]
1116391001675	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
1116391001676	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1116391001677	PemK-like protein; Region: PemK; pfam02452
1116391001678	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1116391001679	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1116391001680	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1116391001681	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1116391001682	RNA binding site [nucleotide binding]; other site
1116391001683	SprT homologues; Region: SprT; cl01182
1116391001684	SprT-like family; Region: SprT-like; pfam10263
1116391001685	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1116391001686	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1116391001687	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1116391001688	dimanganese center [ion binding]; other site
1116391001689	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1116391001690	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1116391001691	active site
1116391001692	catalytic site [active]
1116391001693	metal binding site [ion binding]; metal-binding site
1116391001694	dimer interface [polypeptide binding]; other site
1116391001695	S-layer homology domain; Region: SLH; pfam00395
1116391001696	S-layer homology domain; Region: SLH; pfam00395
1116391001697	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
1116391001698	endonuclease IV; Provisional; Region: PRK01060
1116391001699	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1116391001700	AP (apurinic/apyrimidinic) site pocket; other site
1116391001701	DNA interaction; other site
1116391001702	Metal-binding active site; metal-binding site
1116391001703	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1116391001704	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1116391001705	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1116391001706	putative active site [active]
1116391001707	putative substrate binding site [chemical binding]; other site
1116391001708	putative cosubstrate binding site; other site
1116391001709	catalytic site [active]
1116391001710	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1116391001711	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391001712	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1116391001713	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1116391001714	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1116391001715	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1116391001716	[2Fe-2S] cluster binding site [ion binding]; other site
1116391001717	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1116391001718	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1116391001719	TPP-binding site [chemical binding]; other site
1116391001720	dimer interface [polypeptide binding]; other site
1116391001721	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1116391001722	PYR/PP interface [polypeptide binding]; other site
1116391001723	dimer interface [polypeptide binding]; other site
1116391001724	TPP binding site [chemical binding]; other site
1116391001725	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1116391001726	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1116391001727	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1116391001728	PilZ domain; Region: PilZ; pfam07238
1116391001729	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1116391001730	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1116391001731	active site
1116391001732	dimer interface [polypeptide binding]; other site
1116391001733	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1116391001734	dimer interface [polypeptide binding]; other site
1116391001735	active site
1116391001736	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1116391001737	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1116391001738	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1116391001739	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391001740	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391001741	WHG domain; Region: WHG; pfam13305
1116391001742	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1116391001743	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
1116391001744	Ribosomal protein L35Ae; Region: Ribosomal_L35Ae; cl01033
1116391001745	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1116391001746	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1116391001747	Helix-turn-helix domain; Region: HTH_17; pfam12728
1116391001748	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1116391001749	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391001750	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1116391001751	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1116391001752	active site
1116391001753	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1116391001754	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391001755	putative sugar binding sites [chemical binding]; other site
1116391001756	Q-X-W motif; other site
1116391001757	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1116391001758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001759	active site
1116391001760	phosphorylation site [posttranslational modification]
1116391001761	intermolecular recognition site; other site
1116391001762	LytTr DNA-binding domain; Region: LytTR; smart00850
1116391001763	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391001764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391001765	active site
1116391001766	phosphorylation site [posttranslational modification]
1116391001767	intermolecular recognition site; other site
1116391001768	dimerization interface [polypeptide binding]; other site
1116391001769	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391001770	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1116391001771	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1116391001772	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1116391001773	GAF domain; Region: GAF_3; pfam13492
1116391001774	GAF domain; Region: GAF_2; pfam13185
1116391001775	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391001776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391001777	dimer interface [polypeptide binding]; other site
1116391001778	phosphorylation site [posttranslational modification]
1116391001779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391001780	ATP binding site [chemical binding]; other site
1116391001781	Mg2+ binding site [ion binding]; other site
1116391001782	G-X-G motif; other site
1116391001783	alpha-galactosidase; Provisional; Region: PRK15076
1116391001784	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1116391001785	NAD binding site [chemical binding]; other site
1116391001786	sugar binding site [chemical binding]; other site
1116391001787	divalent metal binding site [ion binding]; other site
1116391001788	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391001789	dimer interface [polypeptide binding]; other site
1116391001790	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1116391001791	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1116391001792	SelR domain; Region: SelR; pfam01641
1116391001793	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
1116391001794	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391001795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391001796	Coenzyme A binding pocket [chemical binding]; other site
1116391001797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391001798	dimerization interface [polypeptide binding]; other site
1116391001799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391001800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391001801	metal binding site [ion binding]; metal-binding site
1116391001802	active site
1116391001803	I-site; other site
1116391001804	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391001805	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1116391001806	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1116391001807	nudix motif; other site
1116391001808	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391001809	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1116391001810	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1116391001811	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1116391001812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391001813	putative substrate translocation pore; other site
1116391001814	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1116391001815	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1116391001816	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1116391001817	conserved cys residue [active]
1116391001818	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391001819	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391001820	metal binding site [ion binding]; metal-binding site
1116391001821	active site
1116391001822	Sulfatase; Region: Sulfatase; cl17466
1116391001823	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1116391001824	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391001825	RNA binding surface [nucleotide binding]; other site
1116391001826	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1116391001827	active site
1116391001828	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1116391001829	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1116391001830	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1116391001831	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1116391001832	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1116391001833	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1116391001834	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391001835	FeS/SAM binding site; other site
1116391001836	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
1116391001837	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1116391001838	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1116391001839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391001840	S-adenosylmethionine binding site [chemical binding]; other site
1116391001841	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1116391001842	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391001843	FeS/SAM binding site; other site
1116391001844	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1116391001845	monogalactosyldiacylglycerol synthase; Region: PLN02605
1116391001846	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1116391001847	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1116391001848	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1116391001849	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1116391001850	active site
1116391001851	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391001852	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1116391001853	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391001854	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
1116391001855	DXD motif; other site
1116391001856	translation initiation factor IF-3; Region: infC; TIGR00168
1116391001857	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1116391001858	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1116391001859	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1116391001860	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1116391001861	23S rRNA binding site [nucleotide binding]; other site
1116391001862	L21 binding site [polypeptide binding]; other site
1116391001863	L13 binding site [polypeptide binding]; other site
1116391001864	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1116391001865	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391001866	active site
1116391001867	metal binding site [ion binding]; metal-binding site
1116391001868	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
1116391001869	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391001870	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1116391001871	active site
1116391001872	metal binding site [ion binding]; metal-binding site
1116391001873	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
1116391001874	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1116391001875	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1116391001876	PYR/PP interface [polypeptide binding]; other site
1116391001877	dimer interface [polypeptide binding]; other site
1116391001878	TPP binding site [chemical binding]; other site
1116391001879	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391001880	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1116391001881	TPP-binding site [chemical binding]; other site
1116391001882	dimer interface [polypeptide binding]; other site
1116391001883	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1116391001884	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1116391001885	putative valine binding site [chemical binding]; other site
1116391001886	dimer interface [polypeptide binding]; other site
1116391001887	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1116391001888	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1116391001889	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1116391001890	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1116391001891	2-isopropylmalate synthase; Validated; Region: PRK00915
1116391001892	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1116391001893	active site
1116391001894	catalytic residues [active]
1116391001895	metal binding site [ion binding]; metal-binding site
1116391001896	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1116391001897	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1116391001898	active site
1116391001899	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391001900	HAMP domain; Region: HAMP; pfam00672
1116391001901	dimerization interface [polypeptide binding]; other site
1116391001902	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391001903	dimer interface [polypeptide binding]; other site
1116391001904	putative CheW interface [polypeptide binding]; other site
1116391001905	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391001906	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391001907	acyl-activating enzyme (AAE) consensus motif; other site
1116391001908	AMP binding site [chemical binding]; other site
1116391001909	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391001910	thioester reductase domain; Region: Thioester-redct; TIGR01746
1116391001911	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1116391001912	putative NAD(P) binding site [chemical binding]; other site
1116391001913	active site
1116391001914	putative substrate binding site [chemical binding]; other site
1116391001915	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1116391001916	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1116391001917	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391001918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391001919	homodimer interface [polypeptide binding]; other site
1116391001920	catalytic residue [active]
1116391001921	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1116391001922	tartrate dehydrogenase; Region: TTC; TIGR02089
1116391001923	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1116391001924	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1116391001925	dimer interface [polypeptide binding]; other site
1116391001926	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1116391001927	catalytic triad [active]
1116391001928	peroxidatic and resolving cysteines [active]
1116391001929	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1116391001930	lipoyl attachment site [posttranslational modification]; other site
1116391001931	KTSC domain; Region: KTSC; pfam13619
1116391001932	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1116391001933	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1116391001934	active site
1116391001935	Substrate binding site; other site
1116391001936	Mg++ binding site; other site
1116391001937	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391001938	putative trimer interface [polypeptide binding]; other site
1116391001939	putative CoA binding site [chemical binding]; other site
1116391001940	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391001941	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1116391001942	active site
1116391001943	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
1116391001944	substrate binding site [chemical binding]; other site
1116391001945	metal binding site [ion binding]; metal-binding site
1116391001946	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1116391001947	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
1116391001948	active site
1116391001949	substrate binding site [chemical binding]; other site
1116391001950	catalytic site [active]
1116391001951	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1116391001952	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391001953	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391001954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
1116391001955	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
1116391001956	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391001957	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1116391001958	DinB superfamily; Region: DinB_2; pfam12867
1116391001959	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1116391001960	CGNR zinc finger; Region: zf-CGNR; pfam11706
1116391001961	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1116391001962	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391001963	active site
1116391001964	catalytic tetrad [active]
1116391001965	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1116391001966	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391001967	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391001968	PAS domain S-box; Region: sensory_box; TIGR00229
1116391001969	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391001970	putative active site [active]
1116391001971	heme pocket [chemical binding]; other site
1116391001972	PAS fold; Region: PAS_3; pfam08447
1116391001973	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1116391001974	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391001975	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391001976	putative active site [active]
1116391001977	heme pocket [chemical binding]; other site
1116391001978	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391001979	dimer interface [polypeptide binding]; other site
1116391001980	phosphorylation site [posttranslational modification]
1116391001981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391001982	ATP binding site [chemical binding]; other site
1116391001983	Mg2+ binding site [ion binding]; other site
1116391001984	G-X-G motif; other site
1116391001985	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1116391001986	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1116391001987	Moco binding site; other site
1116391001988	metal coordination site [ion binding]; other site
1116391001989	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391001990	HTH domain; Region: HTH_11; pfam08279
1116391001991	WYL domain; Region: WYL; pfam13280
1116391001992	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1116391001993	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1116391001994	conserved cys residue [active]
1116391001995	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391001996	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391001997	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391001998	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391001999	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1116391002000	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391002001	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391002002	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391002003	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391002004	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1116391002005	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391002006	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391002007	dimer interface [polypeptide binding]; other site
1116391002008	putative CheW interface [polypeptide binding]; other site
1116391002009	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1116391002010	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391002011	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
1116391002012	ligand binding site [chemical binding]; other site
1116391002013	flexible hinge region; other site
1116391002014	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1116391002015	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1116391002016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391002017	Coenzyme A binding pocket [chemical binding]; other site
1116391002018	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391002019	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391002020	dimer interface [polypeptide binding]; other site
1116391002021	phosphorylation site [posttranslational modification]
1116391002022	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002023	ATP binding site [chemical binding]; other site
1116391002024	Mg2+ binding site [ion binding]; other site
1116391002025	G-X-G motif; other site
1116391002026	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391002027	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002028	active site
1116391002029	phosphorylation site [posttranslational modification]
1116391002030	intermolecular recognition site; other site
1116391002031	dimerization interface [polypeptide binding]; other site
1116391002032	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391002033	DNA binding site [nucleotide binding]
1116391002034	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1116391002035	putative metal binding residues [ion binding]; other site
1116391002036	signature motif; other site
1116391002037	dimer interface [polypeptide binding]; other site
1116391002038	active site
1116391002039	polyP binding site; other site
1116391002040	substrate binding site [chemical binding]; other site
1116391002041	acceptor-phosphate pocket; other site
1116391002042	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1116391002043	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1116391002044	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391002045	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002046	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1116391002047	active site
1116391002048	oxyanion hole [active]
1116391002049	catalytic triad [active]
1116391002050	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1116391002051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002052	putative substrate translocation pore; other site
1116391002053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002054	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391002055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002056	active site
1116391002057	phosphorylation site [posttranslational modification]
1116391002058	intermolecular recognition site; other site
1116391002059	dimerization interface [polypeptide binding]; other site
1116391002060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002061	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391002062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002063	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391002064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391002065	dimerization interface [polypeptide binding]; other site
1116391002066	Histidine kinase; Region: His_kinase; pfam06580
1116391002067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002068	ATP binding site [chemical binding]; other site
1116391002069	Mg2+ binding site [ion binding]; other site
1116391002070	G-X-G motif; other site
1116391002071	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391002072	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1116391002073	ligand binding site [chemical binding]; other site
1116391002074	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391002075	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1116391002076	DNA binding residues [nucleotide binding]
1116391002077	dimer interface [polypeptide binding]; other site
1116391002078	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391002079	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391002080	S-adenosylmethionine binding site [chemical binding]; other site
1116391002081	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1116391002082	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1116391002083	dimer interface [polypeptide binding]; other site
1116391002084	ADP-ribose binding site [chemical binding]; other site
1116391002085	active site
1116391002086	nudix motif; other site
1116391002087	metal binding site [ion binding]; metal-binding site
1116391002088	IDEAL domain; Region: IDEAL; cl07452
1116391002089	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1116391002090	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1116391002091	putative active site [active]
1116391002092	putative FMN binding site [chemical binding]; other site
1116391002093	putative substrate binding site [chemical binding]; other site
1116391002094	putative catalytic residue [active]
1116391002095	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391002096	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391002097	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391002098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391002099	dimerization interface [polypeptide binding]; other site
1116391002100	Histidine kinase; Region: His_kinase; pfam06580
1116391002101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002102	ATP binding site [chemical binding]; other site
1116391002103	Mg2+ binding site [ion binding]; other site
1116391002104	G-X-G motif; other site
1116391002105	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391002106	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002107	active site
1116391002108	phosphorylation site [posttranslational modification]
1116391002109	intermolecular recognition site; other site
1116391002110	dimerization interface [polypeptide binding]; other site
1116391002111	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391002112	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002113	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1116391002114	GntP family permease; Region: GntP_permease; pfam02447
1116391002115	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1116391002116	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1116391002117	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1116391002118	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1116391002119	N- and C-terminal domain interface [polypeptide binding]; other site
1116391002120	active site
1116391002121	catalytic site [active]
1116391002122	metal binding site [ion binding]; metal-binding site
1116391002123	carbohydrate binding site [chemical binding]; other site
1116391002124	ATP binding site [chemical binding]; other site
1116391002125	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1116391002126	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1116391002127	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391002128	NAD binding site [chemical binding]; other site
1116391002129	catalytic Zn binding site [ion binding]; other site
1116391002130	structural Zn binding site [ion binding]; other site
1116391002131	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1116391002132	Coat F domain; Region: Coat_F; pfam07875
1116391002133	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1116391002134	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1116391002135	AsnC family; Region: AsnC_trans_reg; pfam01037
1116391002136	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1116391002137	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
1116391002138	active site
1116391002139	putative substrate binding pocket [chemical binding]; other site
1116391002140	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391002141	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391002142	TM-ABC transporter signature motif; other site
1116391002143	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391002144	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391002145	TM-ABC transporter signature motif; other site
1116391002146	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1116391002147	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391002148	Walker A/P-loop; other site
1116391002149	ATP binding site [chemical binding]; other site
1116391002150	Q-loop/lid; other site
1116391002151	ABC transporter signature motif; other site
1116391002152	Walker B; other site
1116391002153	D-loop; other site
1116391002154	H-loop/switch region; other site
1116391002155	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391002156	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1116391002157	Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304
1116391002158	ligand binding site [chemical binding]; other site
1116391002159	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1116391002160	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1116391002161	[2Fe-2S] cluster binding site [ion binding]; other site
1116391002162	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1116391002163	hydrophobic ligand binding site; other site
1116391002164	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391002165	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391002166	Protein of unknown function (DUF418); Region: DUF418; cl12135
1116391002167	PhoD-like phosphatase; Region: PhoD; pfam09423
1116391002168	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1116391002169	putative active site [active]
1116391002170	putative metal binding site [ion binding]; other site
1116391002171	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1116391002172	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391002173	classical (c) SDRs; Region: SDR_c; cd05233
1116391002174	NAD(P) binding site [chemical binding]; other site
1116391002175	active site
1116391002176	CAAX protease self-immunity; Region: Abi; pfam02517
1116391002177	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391002178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391002179	DNA-binding site [nucleotide binding]; DNA binding site
1116391002180	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391002181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391002182	homodimer interface [polypeptide binding]; other site
1116391002183	catalytic residue [active]
1116391002184	Lysine efflux permease [General function prediction only]; Region: COG1279
1116391002185	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1116391002186	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1116391002187	putative [4Fe-4S] binding site [ion binding]; other site
1116391002188	putative molybdopterin cofactor binding site [chemical binding]; other site
1116391002189	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1116391002190	putative molybdopterin cofactor binding site; other site
1116391002191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391002192	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391002193	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391002194	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391002195	dimer interface [polypeptide binding]; other site
1116391002196	putative CheW interface [polypeptide binding]; other site
1116391002197	amino acid transporter; Region: 2A0306; TIGR00909
1116391002198	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1116391002199	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1116391002200	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1116391002201	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1116391002202	urea carboxylase; Region: urea_carbox; TIGR02712
1116391002203	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1116391002204	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1116391002205	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1116391002206	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1116391002207	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1116391002208	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1116391002209	carboxyltransferase (CT) interaction site; other site
1116391002210	biotinylation site [posttranslational modification]; other site
1116391002211	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1116391002212	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002213	putative substrate translocation pore; other site
1116391002214	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1116391002215	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1116391002216	[4Fe-4S] binding site [ion binding]; other site
1116391002217	molybdopterin cofactor binding site; other site
1116391002218	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1116391002219	molybdopterin cofactor binding site; other site
1116391002220	Sulfatase; Region: Sulfatase; pfam00884
1116391002221	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002222	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391002223	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1116391002224	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391002225	Histidine kinase; Region: HisKA_3; pfam07730
1116391002226	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1116391002227	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1116391002228	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1116391002229	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391002230	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002231	ATP binding site [chemical binding]; other site
1116391002232	G-X-G motif; other site
1116391002233	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002234	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391002235	active site
1116391002236	phosphorylation site [posttranslational modification]
1116391002237	intermolecular recognition site; other site
1116391002238	dimerization interface [polypeptide binding]; other site
1116391002239	YcbB domain; Region: YcbB; pfam08664
1116391002240	Amb_all domain; Region: Amb_all; smart00656
1116391002241	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391002242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002243	dimer interface [polypeptide binding]; other site
1116391002244	conserved gate region; other site
1116391002245	ABC-ATPase subunit interface; other site
1116391002246	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391002247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002248	dimer interface [polypeptide binding]; other site
1116391002249	conserved gate region; other site
1116391002250	putative PBP binding loops; other site
1116391002251	ABC-ATPase subunit interface; other site
1116391002252	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391002253	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1116391002254	Sodium Bile acid symporter family; Region: SBF; cl17470
1116391002255	S-layer homology domain; Region: SLH; pfam00395
1116391002256	S-layer homology domain; Region: SLH; pfam00395
1116391002257	S-layer homology domain; Region: SLH; pfam00395
1116391002258	Spore germination protein; Region: Spore_permease; cl17796
1116391002259	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391002260	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391002261	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391002262	YCII-related domain; Region: YCII; cl00999
1116391002263	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391002264	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1116391002265	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1116391002266	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391002267	Walker A/P-loop; other site
1116391002268	ATP binding site [chemical binding]; other site
1116391002269	Q-loop/lid; other site
1116391002270	ABC transporter signature motif; other site
1116391002271	Walker B; other site
1116391002272	D-loop; other site
1116391002273	H-loop/switch region; other site
1116391002274	TOBE domain; Region: TOBE_2; pfam08402
1116391002275	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1116391002276	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002277	dimer interface [polypeptide binding]; other site
1116391002278	conserved gate region; other site
1116391002279	putative PBP binding loops; other site
1116391002280	ABC-ATPase subunit interface; other site
1116391002281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002282	dimer interface [polypeptide binding]; other site
1116391002283	conserved gate region; other site
1116391002284	putative PBP binding loops; other site
1116391002285	ABC-ATPase subunit interface; other site
1116391002286	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1116391002287	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391002288	motif II; other site
1116391002289	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1116391002290	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1116391002291	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391002292	catalytic residue [active]
1116391002293	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1116391002294	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391002295	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1116391002296	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391002297	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1116391002298	flagellar motor protein MotA; Validated; Region: PRK08124
1116391002299	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1116391002300	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1116391002301	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1116391002302	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1116391002303	ligand binding site [chemical binding]; other site
1116391002304	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
1116391002305	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002306	Phytase; Region: Phytase; cl17685
1116391002307	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1116391002308	putative active site [active]
1116391002309	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1116391002310	metal ion-dependent adhesion site (MIDAS); other site
1116391002311	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1116391002312	metal ion-dependent adhesion site (MIDAS); other site
1116391002313	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391002314	PAS fold; Region: PAS_4; pfam08448
1116391002315	PAS domain S-box; Region: sensory_box; TIGR00229
1116391002316	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391002317	putative active site [active]
1116391002318	heme pocket [chemical binding]; other site
1116391002319	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391002320	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391002321	metal binding site [ion binding]; metal-binding site
1116391002322	active site
1116391002323	I-site; other site
1116391002324	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391002325	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391002326	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391002327	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002328	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002329	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391002330	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391002331	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391002332	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391002333	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1116391002334	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1116391002335	Ligand Binding Site [chemical binding]; other site
1116391002336	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1116391002337	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1116391002338	ligand binding site [chemical binding]; other site
1116391002339	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1116391002340	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391002341	Walker A/P-loop; other site
1116391002342	ATP binding site [chemical binding]; other site
1116391002343	Q-loop/lid; other site
1116391002344	ABC transporter signature motif; other site
1116391002345	Walker B; other site
1116391002346	D-loop; other site
1116391002347	H-loop/switch region; other site
1116391002348	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391002349	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391002350	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391002351	TM-ABC transporter signature motif; other site
1116391002352	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391002353	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391002354	TM-ABC transporter signature motif; other site
1116391002355	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1116391002356	active site
1116391002357	NTP binding site [chemical binding]; other site
1116391002358	metal binding triad [ion binding]; metal-binding site
1116391002359	antibiotic binding site [chemical binding]; other site
1116391002360	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391002361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391002362	S-adenosylmethionine binding site [chemical binding]; other site
1116391002363	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002364	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391002365	putative substrate translocation pore; other site
1116391002366	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002367	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1116391002368	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391002369	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391002370	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1116391002371	motif II; other site
1116391002372	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391002373	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391002374	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391002375	metal binding site [ion binding]; metal-binding site
1116391002376	active site
1116391002377	I-site; other site
1116391002378	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391002379	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1116391002380	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391002381	Zn2+ binding site [ion binding]; other site
1116391002382	Mg2+ binding site [ion binding]; other site
1116391002383	S-layer homology domain; Region: SLH; pfam00395
1116391002384	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1116391002385	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1116391002386	active site
1116391002387	metal binding site [ion binding]; metal-binding site
1116391002388	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1116391002389	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1116391002390	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1116391002391	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391002392	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002393	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1116391002394	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1116391002395	putative active site [active]
1116391002396	metal binding site [ion binding]; metal-binding site
1116391002397	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1116391002398	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391002399	putative trimer interface [polypeptide binding]; other site
1116391002400	putative CoA binding site [chemical binding]; other site
1116391002401	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1116391002402	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1116391002403	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1116391002404	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1116391002405	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1116391002406	active site
1116391002407	tetramer interface; other site
1116391002408	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1116391002409	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1116391002410	putative active site [active]
1116391002411	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1116391002412	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1116391002413	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391002414	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391002415	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1116391002416	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391002417	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391002418	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1116391002419	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1116391002420	active site
1116391002421	dimer interface [polypeptide binding]; other site
1116391002422	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1116391002423	Ligand Binding Site [chemical binding]; other site
1116391002424	Molecular Tunnel; other site
1116391002425	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
1116391002426	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
1116391002427	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1116391002428	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1116391002429	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1116391002430	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1116391002431	Chain length determinant protein; Region: Wzz; cl15801
1116391002432	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1116391002433	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1116391002434	dimerization interface [polypeptide binding]; other site
1116391002435	active site
1116391002436	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1116391002437	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1116391002438	folate binding site [chemical binding]; other site
1116391002439	NADP+ binding site [chemical binding]; other site
1116391002440	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391002441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002442	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391002443	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002444	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1116391002445	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1116391002446	NAD(P) binding site [chemical binding]; other site
1116391002447	LDH/MDH dimer interface [polypeptide binding]; other site
1116391002448	substrate binding site [chemical binding]; other site
1116391002449	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1116391002450	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002451	HTH-like domain; Region: HTH_21; pfam13276
1116391002452	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391002453	Integrase core domain; Region: rve; pfam00665
1116391002454	Integrase core domain; Region: rve_3; pfam13683
1116391002455	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391002456	Transposase; Region: HTH_Tnp_1; pfam01527
1116391002457	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1116391002458	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1116391002459	DXD motif; other site
1116391002460	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
1116391002461	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391002462	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391002463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391002464	Walker A/P-loop; other site
1116391002465	ATP binding site [chemical binding]; other site
1116391002466	Q-loop/lid; other site
1116391002467	ABC transporter signature motif; other site
1116391002468	Walker B; other site
1116391002469	D-loop; other site
1116391002470	H-loop/switch region; other site
1116391002471	hypothetical protein; Provisional; Region: PRK10621
1116391002472	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1116391002473	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391002474	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391002475	active site
1116391002476	metal binding site [ion binding]; metal-binding site
1116391002477	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1116391002478	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1116391002479	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1116391002480	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1116391002481	NAD binding site [chemical binding]; other site
1116391002482	active site
1116391002483	nicotinate phosphoribosyltransferase; Region: PLN02885
1116391002484	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
1116391002485	Spore germination protein; Region: Spore_permease; cl17796
1116391002486	Spore germination protein; Region: Spore_permease; cl17796
1116391002487	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391002488	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391002489	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391002490	HPP family; Region: HPP; pfam04982
1116391002491	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391002492	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391002493	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391002494	dimerization interface [polypeptide binding]; other site
1116391002495	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1116391002496	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391002497	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1116391002498	S-formylglutathione hydrolase; Region: PLN02442
1116391002499	Predicted esterase [General function prediction only]; Region: COG0627
1116391002500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002501	active site
1116391002502	phosphorylation site [posttranslational modification]
1116391002503	intermolecular recognition site; other site
1116391002504	dimerization interface [polypeptide binding]; other site
1116391002505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002506	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391002507	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002508	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391002509	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391002510	dimerization interface [polypeptide binding]; other site
1116391002511	Histidine kinase; Region: His_kinase; pfam06580
1116391002512	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002513	ATP binding site [chemical binding]; other site
1116391002514	Mg2+ binding site [ion binding]; other site
1116391002515	G-X-G motif; other site
1116391002516	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391002517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002518	dimer interface [polypeptide binding]; other site
1116391002519	conserved gate region; other site
1116391002520	ABC-ATPase subunit interface; other site
1116391002521	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391002522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002523	dimer interface [polypeptide binding]; other site
1116391002524	conserved gate region; other site
1116391002525	putative PBP binding loops; other site
1116391002526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391002527	ABC-ATPase subunit interface; other site
1116391002528	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391002529	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391002530	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1116391002531	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391002532	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1116391002533	putative trimer interface [polypeptide binding]; other site
1116391002534	putative CoA binding site [chemical binding]; other site
1116391002535	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391002536	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391002537	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391002538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002539	dimer interface [polypeptide binding]; other site
1116391002540	conserved gate region; other site
1116391002541	putative PBP binding loops; other site
1116391002542	ABC-ATPase subunit interface; other site
1116391002543	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391002544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002545	dimer interface [polypeptide binding]; other site
1116391002546	putative PBP binding loops; other site
1116391002547	ABC-ATPase subunit interface; other site
1116391002548	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1116391002549	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1116391002550	active site
1116391002551	ATP binding site [chemical binding]; other site
1116391002552	substrate binding site [chemical binding]; other site
1116391002553	activation loop (A-loop); other site
1116391002554	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1116391002555	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1116391002556	AAA domain; Region: AAA_31; pfam13614
1116391002557	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
1116391002558	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1116391002559	Walker A motif; other site
1116391002560	ATP binding site [chemical binding]; other site
1116391002561	Walker B motif; other site
1116391002562	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1116391002563	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1116391002564	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1116391002565	active site
1116391002566	metal-dependent hydrolase; Provisional; Region: PRK13291
1116391002567	DinB superfamily; Region: DinB_2; pfam12867
1116391002568	DinB superfamily; Region: DinB_2; pfam12867
1116391002569	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1116391002570	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391002571	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391002572	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391002573	dimerization interface [polypeptide binding]; other site
1116391002574	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391002575	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1116391002576	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1116391002577	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1116391002578	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1116391002579	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1116391002580	GatB domain; Region: GatB_Yqey; smart00845
1116391002581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391002582	Coenzyme A binding pocket [chemical binding]; other site
1116391002583	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391002584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391002585	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1116391002586	MgtC family; Region: MgtC; pfam02308
1116391002587	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1116391002588	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391002589	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1116391002590	DNA binding residues [nucleotide binding]
1116391002591	Putative zinc-finger; Region: zf-HC2; pfam13490
1116391002592	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1116391002593	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1116391002594	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1116391002595	ferric uptake regulator; Provisional; Region: fur; PRK09462
1116391002596	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1116391002597	metal binding site 2 [ion binding]; metal-binding site
1116391002598	putative DNA binding helix; other site
1116391002599	metal binding site 1 [ion binding]; metal-binding site
1116391002600	dimer interface [polypeptide binding]; other site
1116391002601	structural Zn2+ binding site [ion binding]; other site
1116391002602	Bacterial SH3 domain; Region: SH3_3; pfam08239
1116391002603	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1116391002604	active site
1116391002605	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
1116391002606	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1116391002607	thiS-thiF/thiG interaction site; other site
1116391002608	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1116391002609	ThiS interaction site; other site
1116391002610	putative active site [active]
1116391002611	tetramer interface [polypeptide binding]; other site
1116391002612	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1116391002613	active site
1116391002614	catalytic triad [active]
1116391002615	oxyanion hole [active]
1116391002616	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391002617	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1116391002618	NodB motif; other site
1116391002619	active site
1116391002620	catalytic site [active]
1116391002621	metal binding site [ion binding]; metal-binding site
1116391002622	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1116391002623	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1116391002624	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1116391002625	putative active site [active]
1116391002626	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1116391002627	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1116391002628	FOG: CBS domain [General function prediction only]; Region: COG0517
1116391002629	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1116391002630	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1116391002631	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1116391002632	Moco binding site; other site
1116391002633	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1116391002634	metal coordination site [ion binding]; other site
1116391002635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1116391002636	MOSC domain; Region: MOSC; pfam03473
1116391002637	3-alpha domain; Region: 3-alpha; pfam03475
1116391002638	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1116391002639	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1116391002640	GTP binding site; other site
1116391002641	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1116391002642	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391002643	FeS/SAM binding site; other site
1116391002644	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1116391002645	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1116391002646	Src Homology 3 domain superfamily; Region: SH3; cd00174
1116391002647	Bacterial SH3 domain; Region: SH3_3; pfam08239
1116391002648	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391002649	NlpC/P60 family; Region: NLPC_P60; cl17555
1116391002650	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002651	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002652	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1116391002653	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391002654	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391002655	DNA binding residues [nucleotide binding]
1116391002656	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1116391002657	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1116391002658	carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851
1116391002659	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391002660	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391002661	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1116391002662	active site
1116391002663	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391002664	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391002665	active site
1116391002666	metal binding site [ion binding]; metal-binding site
1116391002667	phage shock protein A; Region: phageshock_pspA; TIGR02977
1116391002668	PspC domain; Region: PspC; pfam04024
1116391002669	PspA/IM30 family; Region: PspA_IM30; pfam04012
1116391002670	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1116391002671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391002672	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391002673	dimerization interface [polypeptide binding]; other site
1116391002674	Histidine kinase; Region: HisKA_3; pfam07730
1116391002675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002676	ATP binding site [chemical binding]; other site
1116391002677	Mg2+ binding site [ion binding]; other site
1116391002678	G-X-G motif; other site
1116391002679	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391002680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002681	active site
1116391002682	phosphorylation site [posttranslational modification]
1116391002683	intermolecular recognition site; other site
1116391002684	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391002685	DNA binding residues [nucleotide binding]
1116391002686	dimerization interface [polypeptide binding]; other site
1116391002687	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391002688	Coenzyme A binding pocket [chemical binding]; other site
1116391002689	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391002690	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
1116391002691	sugar binding site [chemical binding]; other site
1116391002692	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1116391002693	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1116391002694	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391002695	Interdomain contacts; other site
1116391002696	S-layer homology domain; Region: SLH; pfam00395
1116391002697	S-layer homology domain; Region: SLH; pfam00395
1116391002698	S-layer homology domain; Region: SLH; pfam00395
1116391002699	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1116391002700	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1116391002701	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1116391002702	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1116391002703	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391002704	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1116391002705	active site
1116391002706	metal binding site [ion binding]; metal-binding site
1116391002707	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1116391002708	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1116391002709	G1 box; other site
1116391002710	putative GEF interaction site [polypeptide binding]; other site
1116391002711	GTP/Mg2+ binding site [chemical binding]; other site
1116391002712	Switch I region; other site
1116391002713	G2 box; other site
1116391002714	G3 box; other site
1116391002715	Switch II region; other site
1116391002716	G4 box; other site
1116391002717	G5 box; other site
1116391002718	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1116391002719	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391002720	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391002721	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391002722	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391002723	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391002724	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391002725	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1116391002726	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391002727	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391002728	Small, acid-soluble spore protein I; Region: SSPI; cl07940
1116391002729	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1116391002730	TrkA-N domain; Region: TrkA_N; pfam02254
1116391002731	TrkA-C domain; Region: TrkA_C; pfam02080
1116391002732	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1116391002733	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1116391002734	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1116391002735	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391002736	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1116391002737	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391002738	MarR family; Region: MarR_2; pfam12802
1116391002739	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391002740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391002741	active site
1116391002742	phosphorylation site [posttranslational modification]
1116391002743	intermolecular recognition site; other site
1116391002744	dimerization interface [polypeptide binding]; other site
1116391002745	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391002746	DNA binding site [nucleotide binding]
1116391002747	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391002748	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391002749	dimerization interface [polypeptide binding]; other site
1116391002750	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391002751	dimer interface [polypeptide binding]; other site
1116391002752	phosphorylation site [posttranslational modification]
1116391002753	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391002754	ATP binding site [chemical binding]; other site
1116391002755	Mg2+ binding site [ion binding]; other site
1116391002756	G-X-G motif; other site
1116391002757	VPS10 domain; Region: VPS10; smart00602
1116391002758	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1116391002759	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1116391002760	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1116391002761	putative transporter; Provisional; Region: PRK10054
1116391002762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002763	putative substrate translocation pore; other site
1116391002764	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1116391002765	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1116391002766	putative active site [active]
1116391002767	catalytic site [active]
1116391002768	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1116391002769	putative active site [active]
1116391002770	catalytic site [active]
1116391002771	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1116391002772	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1116391002773	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1116391002774	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1116391002775	Walker A/P-loop; other site
1116391002776	ATP binding site [chemical binding]; other site
1116391002777	Q-loop/lid; other site
1116391002778	ABC transporter signature motif; other site
1116391002779	Walker B; other site
1116391002780	D-loop; other site
1116391002781	H-loop/switch region; other site
1116391002782	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
1116391002783	cobalt transport protein CbiN; Provisional; Region: PRK02898
1116391002784	cobalt transport protein CbiM; Validated; Region: PRK08319
1116391002785	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1116391002786	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
1116391002787	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391002788	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391002789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002790	dimer interface [polypeptide binding]; other site
1116391002791	conserved gate region; other site
1116391002792	putative PBP binding loops; other site
1116391002793	ABC-ATPase subunit interface; other site
1116391002794	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1116391002795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002796	dimer interface [polypeptide binding]; other site
1116391002797	conserved gate region; other site
1116391002798	putative PBP binding loops; other site
1116391002799	ABC-ATPase subunit interface; other site
1116391002800	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391002801	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391002802	Walker A/P-loop; other site
1116391002803	ATP binding site [chemical binding]; other site
1116391002804	Q-loop/lid; other site
1116391002805	ABC transporter signature motif; other site
1116391002806	Walker B; other site
1116391002807	D-loop; other site
1116391002808	H-loop/switch region; other site
1116391002809	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391002810	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391002811	Walker A/P-loop; other site
1116391002812	ATP binding site [chemical binding]; other site
1116391002813	Q-loop/lid; other site
1116391002814	ABC transporter signature motif; other site
1116391002815	Predicted membrane protein [Function unknown]; Region: COG1511
1116391002816	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1116391002817	Predicted membrane protein [Function unknown]; Region: COG1511
1116391002818	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1116391002819	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1116391002820	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391002821	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391002822	DNA binding site [nucleotide binding]
1116391002823	domain linker motif; other site
1116391002824	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1116391002825	dimerization interface [polypeptide binding]; other site
1116391002826	ligand binding site [chemical binding]; other site
1116391002827	sodium binding site [ion binding]; other site
1116391002828	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391002829	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391002830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002831	dimer interface [polypeptide binding]; other site
1116391002832	conserved gate region; other site
1116391002833	putative PBP binding loops; other site
1116391002834	ABC-ATPase subunit interface; other site
1116391002835	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391002836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391002837	dimer interface [polypeptide binding]; other site
1116391002838	conserved gate region; other site
1116391002839	putative PBP binding loops; other site
1116391002840	ABC-ATPase subunit interface; other site
1116391002841	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1116391002842	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391002843	substrate binding [chemical binding]; other site
1116391002844	active site
1116391002845	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391002846	azoreductase; Reviewed; Region: PRK00170
1116391002847	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391002848	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391002849	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391002850	active site
1116391002851	catalytic tetrad [active]
1116391002852	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1116391002853	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1116391002854	NAD(P) binding site [chemical binding]; other site
1116391002855	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1116391002856	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1116391002857	catalytic residues [active]
1116391002858	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391002859	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391002860	DNA binding residues [nucleotide binding]
1116391002861	dimerization interface [polypeptide binding]; other site
1116391002862	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1116391002863	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1116391002864	PYR/PP interface [polypeptide binding]; other site
1116391002865	dimer interface [polypeptide binding]; other site
1116391002866	TPP binding site [chemical binding]; other site
1116391002867	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391002868	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1116391002869	TPP-binding site [chemical binding]; other site
1116391002870	dimer interface [polypeptide binding]; other site
1116391002871	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1116391002872	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1116391002873	putative valine binding site [chemical binding]; other site
1116391002874	dimer interface [polypeptide binding]; other site
1116391002875	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1116391002876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391002877	dimerization interface [polypeptide binding]; other site
1116391002878	putative DNA binding site [nucleotide binding]; other site
1116391002879	putative Zn2+ binding site [ion binding]; other site
1116391002880	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391002881	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391002882	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391002883	dimerization interface [polypeptide binding]; other site
1116391002884	DinB superfamily; Region: DinB_2; pfam12867
1116391002885	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
1116391002886	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391002887	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391002888	Protein of unknown function DUF111; Region: DUF111; cl03398
1116391002889	hypothetical protein; Provisional; Region: PRK04194
1116391002890	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1116391002891	AIR carboxylase; Region: AIRC; smart01001
1116391002892	lipoyl synthase; Provisional; Region: PRK05481
1116391002893	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391002894	FeS/SAM binding site; other site
1116391002895	Protein of unknown function (DUF1027); Region: DUF1027; pfam06265
1116391002896	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1116391002897	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1116391002898	PilZ domain; Region: PilZ; pfam07238
1116391002899	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1116391002900	putative homodimer interface [polypeptide binding]; other site
1116391002901	putative active site pocket [active]
1116391002902	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1116391002903	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1116391002904	Nucleoside recognition; Region: Gate; pfam07670
1116391002905	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1116391002906	apolar tunnel; other site
1116391002907	heme binding site [chemical binding]; other site
1116391002908	dimerization interface [polypeptide binding]; other site
1116391002909	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
1116391002910	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
1116391002911	YycC-like protein; Region: YycC; pfam14174
1116391002912	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1116391002913	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391002914	dimer interface [polypeptide binding]; other site
1116391002915	putative metal binding site [ion binding]; other site
1116391002916	General stress protein [General function prediction only]; Region: GsiB; COG3729
1116391002917	General stress protein [General function prediction only]; Region: GsiB; COG3729
1116391002918	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1116391002919	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1116391002920	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1116391002921	putative active site [active]
1116391002922	putative metal binding site [ion binding]; other site
1116391002923	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1116391002924	active site
1116391002925	catalytic residues [active]
1116391002926	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
1116391002927	TIGR03943 family protein; Region: TIGR03943
1116391002928	Predicted permease; Region: DUF318; cl17795
1116391002929	Predicted permease; Region: DUF318; cl17795
1116391002930	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1116391002931	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1116391002932	active site
1116391002933	HIGH motif; other site
1116391002934	dimer interface [polypeptide binding]; other site
1116391002935	KMSKS motif; other site
1116391002936	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1116391002937	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391002938	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391002939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391002940	Walker A/P-loop; other site
1116391002941	ATP binding site [chemical binding]; other site
1116391002942	Q-loop/lid; other site
1116391002943	ABC transporter signature motif; other site
1116391002944	Walker B; other site
1116391002945	D-loop; other site
1116391002946	H-loop/switch region; other site
1116391002947	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391002948	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391002949	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391002950	Walker A/P-loop; other site
1116391002951	ATP binding site [chemical binding]; other site
1116391002952	Q-loop/lid; other site
1116391002953	ABC transporter signature motif; other site
1116391002954	Walker B; other site
1116391002955	D-loop; other site
1116391002956	H-loop/switch region; other site
1116391002957	Cupin domain; Region: Cupin_2; pfam07883
1116391002958	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391002959	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391002960	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1116391002961	beta-galactosidase; Region: BGL; TIGR03356
1116391002962	MFS/sugar transport protein; Region: MFS_2; pfam13347
1116391002963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391002964	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391002965	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391002966	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391002967	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1116391002968	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391002969	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1116391002970	E-class dimer interface [polypeptide binding]; other site
1116391002971	P-class dimer interface [polypeptide binding]; other site
1116391002972	active site
1116391002973	Cu2+ binding site [ion binding]; other site
1116391002974	Zn2+ binding site [ion binding]; other site
1116391002975	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391002976	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391002977	active site
1116391002978	catalytic tetrad [active]
1116391002979	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391002980	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1116391002981	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1116391002982	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1116391002983	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1116391002984	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1116391002985	DHHA2 domain; Region: DHHA2; pfam02833
1116391002986	Amb_all domain; Region: Amb_all; smart00656
1116391002987	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1116391002988	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1116391002989	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
1116391002990	NAD binding site [chemical binding]; other site
1116391002991	dimer interface [polypeptide binding]; other site
1116391002992	substrate binding site [chemical binding]; other site
1116391002993	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391002994	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1116391002995	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1116391002996	DinB superfamily; Region: DinB_2; pfam12867
1116391002997	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
1116391002998	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391002999	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391003000	NAD(P) binding site [chemical binding]; other site
1116391003001	active site
1116391003002	short chain dehydrogenase; Provisional; Region: PRK06914
1116391003003	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1116391003004	NADP binding site [chemical binding]; other site
1116391003005	active site
1116391003006	steroid binding site; other site
1116391003007	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391003008	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391003009	active site
1116391003010	catalytic tetrad [active]
1116391003011	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1116391003012	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1116391003013	Walker A/P-loop; other site
1116391003014	ATP binding site [chemical binding]; other site
1116391003015	Q-loop/lid; other site
1116391003016	ABC transporter signature motif; other site
1116391003017	Walker B; other site
1116391003018	D-loop; other site
1116391003019	H-loop/switch region; other site
1116391003020	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1116391003021	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1116391003022	Walker A/P-loop; other site
1116391003023	ATP binding site [chemical binding]; other site
1116391003024	Q-loop/lid; other site
1116391003025	ABC transporter signature motif; other site
1116391003026	Walker B; other site
1116391003027	D-loop; other site
1116391003028	H-loop/switch region; other site
1116391003029	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1116391003030	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1116391003031	TM-ABC transporter signature motif; other site
1116391003032	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1116391003033	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391003034	TM-ABC transporter signature motif; other site
1116391003035	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1116391003036	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1116391003037	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1116391003038	alpha-gamma subunit interface [polypeptide binding]; other site
1116391003039	beta-gamma subunit interface [polypeptide binding]; other site
1116391003040	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1116391003041	gamma-beta subunit interface [polypeptide binding]; other site
1116391003042	alpha-beta subunit interface [polypeptide binding]; other site
1116391003043	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1116391003044	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1116391003045	subunit interactions [polypeptide binding]; other site
1116391003046	active site
1116391003047	flap region; other site
1116391003048	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391003049	Walker A motif; other site
1116391003050	ATP binding site [chemical binding]; other site
1116391003051	arginine finger; other site
1116391003052	UreD urease accessory protein; Region: UreD; cl00530
1116391003053	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1116391003054	UbiA prenyltransferase family; Region: UbiA; pfam01040
1116391003055	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1116391003056	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1116391003057	Cu(I) binding site [ion binding]; other site
1116391003058	Predicted permeases [General function prediction only]; Region: COG0679
1116391003059	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1116391003060	active site
1116391003061	metal binding site [ion binding]; metal-binding site
1116391003062	S-layer homology domain; Region: SLH; pfam00395
1116391003063	S-layer homology domain; Region: SLH; pfam00395
1116391003064	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003065	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391003066	putative substrate translocation pore; other site
1116391003067	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1116391003068	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1116391003069	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1116391003070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391003071	motif II; other site
1116391003072	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1116391003073	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1116391003074	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391003075	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1116391003076	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1116391003077	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391003078	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1116391003079	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1116391003080	intersubunit interface [polypeptide binding]; other site
1116391003081	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1116391003082	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1116391003083	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1116391003084	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391003085	ABC-ATPase subunit  interface; other site
1116391003086	dimer interface [polypeptide binding]; other site
1116391003087	putative PBP binding regions; other site
1116391003088	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391003089	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1116391003090	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1116391003091	active site
1116391003092	dimer interface [polypeptide binding]; other site
1116391003093	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1116391003094	Ligand Binding Site [chemical binding]; other site
1116391003095	Molecular Tunnel; other site
1116391003096	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1116391003097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391003098	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1116391003099	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1116391003100	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1116391003101	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1116391003102	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1116391003103	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391003104	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1116391003105	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1116391003106	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1116391003107	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391003108	catalytic residues [active]
1116391003109	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1116391003110	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1116391003111	EamA-like transporter family; Region: EamA; pfam00892
1116391003112	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1116391003113	EamA-like transporter family; Region: EamA; pfam00892
1116391003114	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1116391003115	classical (c) SDRs; Region: SDR_c; cd05233
1116391003116	NAD(P) binding site [chemical binding]; other site
1116391003117	active site
1116391003118	NifU-like domain; Region: NifU; cl00484
1116391003119	hypothetical protein; Provisional; Region: PRK13669
1116391003120	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1116391003121	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391003122	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
1116391003123	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391003124	FeS/SAM binding site; other site
1116391003125	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1116391003126	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1116391003127	Tic20-like protein; Region: Tic20; pfam09685
1116391003128	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1116391003129	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391003130	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391003131	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1116391003132	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391003133	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1116391003134	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1116391003135	active site
1116391003136	putative heme peroxidase; Provisional; Region: PRK12276
1116391003137	Putative membrane protein; Region: YuiB; pfam14068
1116391003138	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1116391003139	primosomal protein DnaI; Reviewed; Region: PRK08939
1116391003140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391003141	Walker A motif; other site
1116391003142	ATP binding site [chemical binding]; other site
1116391003143	Walker B motif; other site
1116391003144	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391003145	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391003146	catalytic residues [active]
1116391003147	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1116391003148	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1116391003149	GIY-YIG motif/motif A; other site
1116391003150	active site
1116391003151	catalytic site [active]
1116391003152	putative DNA binding site [nucleotide binding]; other site
1116391003153	metal binding site [ion binding]; metal-binding site
1116391003154	UvrB/uvrC motif; Region: UVR; pfam02151
1116391003155	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1116391003156	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1116391003157	DNA binding site [nucleotide binding]
1116391003158	CAAX protease self-immunity; Region: Abi; pfam02517
1116391003159	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1116391003160	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1116391003161	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1116391003162	TrkA-N domain; Region: TrkA_N; pfam02254
1116391003163	TrkA-C domain; Region: TrkA_C; pfam02080
1116391003164	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1116391003165	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1116391003166	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391003167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391003168	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391003169	dimerization interface [polypeptide binding]; other site
1116391003170	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1116391003171	putative Iron-sulfur protein interface [polypeptide binding]; other site
1116391003172	proximal heme binding site [chemical binding]; other site
1116391003173	distal heme binding site [chemical binding]; other site
1116391003174	putative dimer interface [polypeptide binding]; other site
1116391003175	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1116391003176	L-aspartate oxidase; Provisional; Region: PRK06175
1116391003177	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1116391003178	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1116391003179	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1116391003180	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391003181	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391003182	DNA binding site [nucleotide binding]
1116391003183	domain linker motif; other site
1116391003184	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391003185	ligand binding site [chemical binding]; other site
1116391003186	dimerization interface [polypeptide binding]; other site
1116391003187	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391003188	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1116391003189	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1116391003190	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1116391003191	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391003192	Histidine kinase; Region: HisKA_3; pfam07730
1116391003193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003194	ATP binding site [chemical binding]; other site
1116391003195	Mg2+ binding site [ion binding]; other site
1116391003196	G-X-G motif; other site
1116391003197	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391003198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391003199	active site
1116391003200	phosphorylation site [posttranslational modification]
1116391003201	intermolecular recognition site; other site
1116391003202	dimerization interface [polypeptide binding]; other site
1116391003203	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391003204	DNA binding residues [nucleotide binding]
1116391003205	dimerization interface [polypeptide binding]; other site
1116391003206	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1116391003207	Putative sensor; Region: Sensor; pfam13796
1116391003208	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1116391003209	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1116391003210	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391003211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391003212	active site
1116391003213	phosphorylation site [posttranslational modification]
1116391003214	intermolecular recognition site; other site
1116391003215	dimerization interface [polypeptide binding]; other site
1116391003216	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003217	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003218	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391003219	dimerization interface [polypeptide binding]; other site
1116391003220	Histidine kinase; Region: His_kinase; pfam06580
1116391003221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003222	ATP binding site [chemical binding]; other site
1116391003223	Mg2+ binding site [ion binding]; other site
1116391003224	G-X-G motif; other site
1116391003225	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003226	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003227	dimer interface [polypeptide binding]; other site
1116391003228	conserved gate region; other site
1116391003229	ABC-ATPase subunit interface; other site
1116391003230	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003231	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003232	dimer interface [polypeptide binding]; other site
1116391003233	conserved gate region; other site
1116391003234	putative PBP binding loops; other site
1116391003235	ABC-ATPase subunit interface; other site
1116391003236	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391003237	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391003238	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003239	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391003240	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391003241	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391003242	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391003243	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391003244	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391003245	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391003246	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391003247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003248	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003250	dimer interface [polypeptide binding]; other site
1116391003251	conserved gate region; other site
1116391003252	ABC-ATPase subunit interface; other site
1116391003253	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003255	dimer interface [polypeptide binding]; other site
1116391003256	conserved gate region; other site
1116391003257	putative PBP binding loops; other site
1116391003258	ABC-ATPase subunit interface; other site
1116391003259	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003260	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1116391003261	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1116391003262	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391003263	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1116391003264	synthetase active site [active]
1116391003265	NTP binding site [chemical binding]; other site
1116391003266	metal binding site [ion binding]; metal-binding site
1116391003267	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391003268	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391003269	sequence-specific DNA binding site [nucleotide binding]; other site
1116391003270	salt bridge; other site
1116391003271	Cupin domain; Region: Cupin_2; pfam07883
1116391003272	LysE type translocator; Region: LysE; cl00565
1116391003273	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1116391003274	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1116391003275	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1116391003276	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391003277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003278	putative substrate translocation pore; other site
1116391003279	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391003280	putative DNA binding site [nucleotide binding]; other site
1116391003281	dimerization interface [polypeptide binding]; other site
1116391003282	putative Zn2+ binding site [ion binding]; other site
1116391003283	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1116391003284	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1116391003285	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391003286	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1116391003287	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391003288	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1116391003289	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1116391003290	Walker A/P-loop; other site
1116391003291	ATP binding site [chemical binding]; other site
1116391003292	Q-loop/lid; other site
1116391003293	ABC transporter signature motif; other site
1116391003294	Walker B; other site
1116391003295	D-loop; other site
1116391003296	H-loop/switch region; other site
1116391003297	TOBE domain; Region: TOBE_2; pfam08402
1116391003298	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003300	dimer interface [polypeptide binding]; other site
1116391003301	putative PBP binding loops; other site
1116391003302	ABC-ATPase subunit interface; other site
1116391003303	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003305	dimer interface [polypeptide binding]; other site
1116391003306	conserved gate region; other site
1116391003307	ABC-ATPase subunit interface; other site
1116391003308	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003309	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391003310	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1116391003311	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
1116391003312	active site
1116391003313	catalytic site [active]
1116391003314	metal binding site [ion binding]; metal-binding site
1116391003315	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391003316	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391003317	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003318	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003319	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003320	dimer interface [polypeptide binding]; other site
1116391003321	ABC-ATPase subunit interface; other site
1116391003322	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003324	dimer interface [polypeptide binding]; other site
1116391003325	conserved gate region; other site
1116391003326	putative PBP binding loops; other site
1116391003327	ABC-ATPase subunit interface; other site
1116391003328	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1116391003329	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391003330	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391003331	Coenzyme A binding pocket [chemical binding]; other site
1116391003332	Predicted membrane protein [Function unknown]; Region: COG2311
1116391003333	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1116391003334	Protein of unknown function (DUF3888); Region: DUF3888; pfam13027
1116391003335	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1116391003336	active site
1116391003337	substrate binding site [chemical binding]; other site
1116391003338	trimer interface [polypeptide binding]; other site
1116391003339	CoA binding site [chemical binding]; other site
1116391003340	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1116391003341	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1116391003342	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003343	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003344	short chain dehydrogenase; Provisional; Region: PRK12747
1116391003345	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1116391003346	NADP binding site [chemical binding]; other site
1116391003347	homodimer interface [polypeptide binding]; other site
1116391003348	active site
1116391003349	substrate binding site [chemical binding]; other site
1116391003350	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1116391003351	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391003352	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1116391003353	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1116391003354	DoxX-like family; Region: DoxX_2; pfam13564
1116391003355	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391003356	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391003357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003358	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391003359	putative substrate translocation pore; other site
1116391003360	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391003361	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391003362	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391003363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391003364	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391003365	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391003366	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391003367	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1116391003368	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391003369	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391003370	Coenzyme A binding pocket [chemical binding]; other site
1116391003371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391003372	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1116391003373	NAD(P) binding site [chemical binding]; other site
1116391003374	active site
1116391003375	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1116391003376	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391003377	DNA binding residues [nucleotide binding]
1116391003378	putative dimer interface [polypeptide binding]; other site
1116391003379	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
1116391003380	putative dimer interface [polypeptide binding]; other site
1116391003381	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391003382	DinB superfamily; Region: DinB_2; pfam12867
1116391003383	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003385	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1116391003386	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1116391003387	homotrimer interaction site [polypeptide binding]; other site
1116391003388	putative active site [active]
1116391003389	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003390	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003391	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003392	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391003393	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391003394	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391003395	Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718
1116391003396	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391003398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003399	putative PBP binding loops; other site
1116391003400	dimer interface [polypeptide binding]; other site
1116391003401	ABC-ATPase subunit interface; other site
1116391003402	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003404	dimer interface [polypeptide binding]; other site
1116391003405	conserved gate region; other site
1116391003406	putative PBP binding loops; other site
1116391003407	ABC-ATPase subunit interface; other site
1116391003408	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003409	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391003410	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1116391003411	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391003412	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391003413	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391003414	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1116391003415	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391003416	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391003417	DNA binding site [nucleotide binding]
1116391003418	domain linker motif; other site
1116391003419	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391003420	dimerization interface [polypeptide binding]; other site
1116391003421	ligand binding site [chemical binding]; other site
1116391003422	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003423	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391003424	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003426	dimer interface [polypeptide binding]; other site
1116391003427	conserved gate region; other site
1116391003428	putative PBP binding loops; other site
1116391003429	ABC-ATPase subunit interface; other site
1116391003430	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003431	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003432	dimer interface [polypeptide binding]; other site
1116391003433	conserved gate region; other site
1116391003434	putative PBP binding loops; other site
1116391003435	ABC-ATPase subunit interface; other site
1116391003436	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1116391003437	beta-galactosidase; Region: BGL; TIGR03356
1116391003438	S-layer homology domain; Region: SLH; pfam00395
1116391003439	S-layer homology domain; Region: SLH; pfam00395
1116391003440	S-layer homology domain; Region: SLH; pfam00395
1116391003441	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1116391003442	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1116391003443	active site
1116391003444	catalytic residues [active]
1116391003445	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1116391003446	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391003447	metal binding site [ion binding]; metal-binding site
1116391003448	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1116391003449	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1116391003450	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391003451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391003452	active site
1116391003453	phosphorylation site [posttranslational modification]
1116391003454	intermolecular recognition site; other site
1116391003455	dimerization interface [polypeptide binding]; other site
1116391003456	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003457	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003458	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391003459	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391003460	dimerization interface [polypeptide binding]; other site
1116391003461	Histidine kinase; Region: His_kinase; pfam06580
1116391003462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003463	ATP binding site [chemical binding]; other site
1116391003464	Mg2+ binding site [ion binding]; other site
1116391003465	G-X-G motif; other site
1116391003466	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391003467	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003468	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1116391003469	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1116391003470	active site
1116391003471	active site
1116391003472	catalytic residues [active]
1116391003473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1116391003474	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1116391003475	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391003476	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391003477	active site
1116391003478	metal binding site [ion binding]; metal-binding site
1116391003479	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391003480	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391003481	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391003482	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391003483	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391003484	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391003485	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391003486	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391003487	Interdomain contacts; other site
1116391003488	Cytokine receptor motif; other site
1116391003489	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391003490	Interdomain contacts; other site
1116391003491	Cytokine receptor motif; other site
1116391003492	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391003493	Interdomain contacts; other site
1116391003494	Cytokine receptor motif; other site
1116391003495	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391003496	dockerin binding interface; other site
1116391003497	BCCT family transporter; Region: BCCT; pfam02028
1116391003498	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391003499	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391003500	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391003501	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391003502	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391003503	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1116391003504	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391003505	Cache domain; Region: Cache_1; pfam02743
1116391003506	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391003507	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391003508	dimerization interface [polypeptide binding]; other site
1116391003509	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391003510	dimer interface [polypeptide binding]; other site
1116391003511	putative CheW interface [polypeptide binding]; other site
1116391003512	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391003513	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391003514	The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442
1116391003515	putative dimerization interface [polypeptide binding]; other site
1116391003516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003517	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391003518	putative substrate translocation pore; other site
1116391003519	Nitronate monooxygenase; Region: NMO; pfam03060
1116391003520	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1116391003521	FMN binding site [chemical binding]; other site
1116391003522	substrate binding site [chemical binding]; other site
1116391003523	putative catalytic residue [active]
1116391003524	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391003525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391003526	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391003527	binding surface
1116391003528	TPR motif; other site
1116391003529	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1116391003530	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391003531	DinB family; Region: DinB; cl17821
1116391003532	DinB superfamily; Region: DinB_2; pfam12867
1116391003533	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391003534	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391003535	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1116391003536	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1116391003537	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391003538	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391003539	active site
1116391003540	catalytic tetrad [active]
1116391003541	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1116391003542	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003543	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391003544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391003546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391003547	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391003548	dimerization interface [polypeptide binding]; other site
1116391003549	putative DNA binding site [nucleotide binding]; other site
1116391003550	putative Zn2+ binding site [ion binding]; other site
1116391003551	arsenical pump membrane protein; Provisional; Region: PRK15445
1116391003552	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1116391003553	transmembrane helices; other site
1116391003554	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1116391003555	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1116391003556	active site
1116391003557	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1116391003558	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391003559	putative metal binding site [ion binding]; other site
1116391003560	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1116391003561	active site
1116391003562	catalytic residues [active]
1116391003563	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1116391003564	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1116391003565	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1116391003566	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391003567	putative metal binding site [ion binding]; other site
1116391003568	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1116391003569	MarR family; Region: MarR_2; cl17246
1116391003570	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1116391003571	FtsX-like permease family; Region: FtsX; pfam02687
1116391003572	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391003573	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391003574	Walker A/P-loop; other site
1116391003575	ATP binding site [chemical binding]; other site
1116391003576	Q-loop/lid; other site
1116391003577	ABC transporter signature motif; other site
1116391003578	Walker B; other site
1116391003579	D-loop; other site
1116391003580	H-loop/switch region; other site
1116391003581	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391003582	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391003583	dimer interface [polypeptide binding]; other site
1116391003584	phosphorylation site [posttranslational modification]
1116391003585	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003586	ATP binding site [chemical binding]; other site
1116391003587	Mg2+ binding site [ion binding]; other site
1116391003588	G-X-G motif; other site
1116391003589	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391003590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391003591	intermolecular recognition site; other site
1116391003592	active site
1116391003593	dimerization interface [polypeptide binding]; other site
1116391003594	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391003595	DNA binding site [nucleotide binding]
1116391003596	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003598	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391003599	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
1116391003600	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391003601	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003602	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003603	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003604	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391003605	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1116391003606	active site
1116391003607	metal binding site [ion binding]; metal-binding site
1116391003608	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1116391003609	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391003610	DNA binding residues [nucleotide binding]
1116391003611	drug binding residues [chemical binding]; other site
1116391003612	dimer interface [polypeptide binding]; other site
1116391003613	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1116391003614	short chain dehydrogenase; Provisional; Region: PRK12747
1116391003615	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1116391003616	NADP binding site [chemical binding]; other site
1116391003617	homodimer interface [polypeptide binding]; other site
1116391003618	active site
1116391003619	substrate binding site [chemical binding]; other site
1116391003620	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391003621	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1116391003622	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391003623	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1116391003624	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1116391003625	putative substrate binding site [chemical binding]; other site
1116391003626	putative ATP binding site [chemical binding]; other site
1116391003627	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1116391003628	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1116391003629	active site
1116391003630	P-loop; other site
1116391003631	phosphorylation site [posttranslational modification]
1116391003632	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1116391003633	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1116391003634	active site
1116391003635	phosphorylation site [posttranslational modification]
1116391003636	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1116391003637	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391003638	active site
1116391003639	catalytic triad [active]
1116391003640	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1116391003641	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1116391003642	NAD(P) binding site [chemical binding]; other site
1116391003643	catalytic residues [active]
1116391003644	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003645	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391003646	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1116391003647	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391003648	ligand binding site [chemical binding]; other site
1116391003649	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391003650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391003651	active site
1116391003652	phosphorylation site [posttranslational modification]
1116391003653	intermolecular recognition site; other site
1116391003654	dimerization interface [polypeptide binding]; other site
1116391003655	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003656	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003657	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003658	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391003659	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391003660	dimerization interface [polypeptide binding]; other site
1116391003661	Histidine kinase; Region: His_kinase; pfam06580
1116391003662	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003663	ATP binding site [chemical binding]; other site
1116391003664	Mg2+ binding site [ion binding]; other site
1116391003665	G-X-G motif; other site
1116391003666	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1116391003667	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391003668	putative ligand binding site [chemical binding]; other site
1116391003669	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391003670	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391003671	Walker A/P-loop; other site
1116391003672	ATP binding site [chemical binding]; other site
1116391003673	Q-loop/lid; other site
1116391003674	ABC transporter signature motif; other site
1116391003675	Walker B; other site
1116391003676	D-loop; other site
1116391003677	H-loop/switch region; other site
1116391003678	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391003679	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391003680	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391003681	TM-ABC transporter signature motif; other site
1116391003682	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391003683	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391003684	TM-ABC transporter signature motif; other site
1116391003685	LrgB-like family; Region: LrgB; cl00596
1116391003686	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1116391003687	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391003688	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391003689	Domain of unknown function (DUF1961); Region: DUF1961; pfam09224
1116391003690	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391003691	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391003692	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391003693	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391003694	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003695	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003697	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
1116391003698	putative active site [active]
1116391003699	putative metal binding site [ion binding]; other site
1116391003700	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391003701	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
1116391003702	putative hydrophobic ligand binding site [chemical binding]; other site
1116391003703	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583
1116391003704	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1116391003705	putative active site [active]
1116391003706	catalytic site [active]
1116391003707	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391003708	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1116391003709	active site
1116391003710	metal binding site [ion binding]; metal-binding site
1116391003711	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1116391003712	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1116391003713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003714	dimer interface [polypeptide binding]; other site
1116391003715	conserved gate region; other site
1116391003716	ABC-ATPase subunit interface; other site
1116391003717	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1116391003718	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1116391003719	Walker A/P-loop; other site
1116391003720	ATP binding site [chemical binding]; other site
1116391003721	Q-loop/lid; other site
1116391003722	ABC transporter signature motif; other site
1116391003723	Walker B; other site
1116391003724	D-loop; other site
1116391003725	H-loop/switch region; other site
1116391003726	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1116391003727	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391003728	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1116391003729	substrate binding site [chemical binding]; other site
1116391003730	dimer interface [polypeptide binding]; other site
1116391003731	ATP binding site [chemical binding]; other site
1116391003732	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
1116391003733	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391003734	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391003735	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391003736	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391003737	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391003738	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391003739	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391003740	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391003741	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391003742	active site
1116391003743	catalytic tetrad [active]
1116391003744	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391003745	putative substrate translocation pore; other site
1116391003746	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391003747	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1116391003748	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1116391003749	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1116391003750	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391003751	metal binding site [ion binding]; metal-binding site
1116391003752	Carbohydrate binding module (family 6); Region: CBM_6; pfam03422
1116391003753	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391003754	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391003755	metal binding site [ion binding]; metal-binding site
1116391003756	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1116391003757	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391003758	S-layer homology domain; Region: SLH; pfam00395
1116391003759	S-layer homology domain; Region: SLH; pfam00395
1116391003760	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391003761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391003762	non-specific DNA binding site [nucleotide binding]; other site
1116391003763	salt bridge; other site
1116391003764	sequence-specific DNA binding site [nucleotide binding]; other site
1116391003765	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1116391003766	SpoVR like protein; Region: SpoVR; pfam04293
1116391003767	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
1116391003768	asparagine synthetase AsnA; Provisional; Region: PRK05425
1116391003769	motif 1; other site
1116391003770	dimer interface [polypeptide binding]; other site
1116391003771	active site
1116391003772	motif 2; other site
1116391003773	motif 3; other site
1116391003774	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1116391003775	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391003776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391003777	dimer interface [polypeptide binding]; other site
1116391003778	phosphorylation site [posttranslational modification]
1116391003779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003780	ATP binding site [chemical binding]; other site
1116391003781	Mg2+ binding site [ion binding]; other site
1116391003782	G-X-G motif; other site
1116391003783	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391003784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391003785	active site
1116391003786	phosphorylation site [posttranslational modification]
1116391003787	intermolecular recognition site; other site
1116391003788	dimerization interface [polypeptide binding]; other site
1116391003789	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391003790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391003791	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391003792	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391003793	dimerization interface [polypeptide binding]; other site
1116391003794	Histidine kinase; Region: His_kinase; pfam06580
1116391003795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003796	ATP binding site [chemical binding]; other site
1116391003797	Mg2+ binding site [ion binding]; other site
1116391003798	G-X-G motif; other site
1116391003799	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391003800	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391003801	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391003802	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003803	dimer interface [polypeptide binding]; other site
1116391003804	conserved gate region; other site
1116391003805	ABC-ATPase subunit interface; other site
1116391003806	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391003807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003808	dimer interface [polypeptide binding]; other site
1116391003809	conserved gate region; other site
1116391003810	ABC-ATPase subunit interface; other site
1116391003811	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1116391003812	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1116391003813	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1116391003814	active site
1116391003815	catalytic residues [active]
1116391003816	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
1116391003817	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1116391003818	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1116391003819	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
1116391003820	ethanolamine permease; Region: 2A0305; TIGR00908
1116391003821	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391003822	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
1116391003823	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1116391003824	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391003825	active site
1116391003826	putative pectinesterase; Region: PLN02432; cl01911
1116391003827	Pectinesterase; Region: Pectinesterase; pfam01095
1116391003828	threonine synthase; Validated; Region: PRK08197
1116391003829	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1116391003830	homodimer interface [polypeptide binding]; other site
1116391003831	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391003832	catalytic residue [active]
1116391003833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003834	dimer interface [polypeptide binding]; other site
1116391003835	conserved gate region; other site
1116391003836	putative PBP binding loops; other site
1116391003837	ABC-ATPase subunit interface; other site
1116391003838	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391003839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391003840	dimer interface [polypeptide binding]; other site
1116391003841	conserved gate region; other site
1116391003842	putative PBP binding loops; other site
1116391003843	ABC-ATPase subunit interface; other site
1116391003844	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391003845	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391003846	Walker A/P-loop; other site
1116391003847	ATP binding site [chemical binding]; other site
1116391003848	Q-loop/lid; other site
1116391003849	ABC transporter signature motif; other site
1116391003850	Walker B; other site
1116391003851	D-loop; other site
1116391003852	H-loop/switch region; other site
1116391003853	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1116391003854	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391003855	substrate binding pocket [chemical binding]; other site
1116391003856	membrane-bound complex binding site; other site
1116391003857	hinge residues; other site
1116391003858	FAD binding site [chemical binding]; other site
1116391003859	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
1116391003860	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1116391003861	putative active site [active]
1116391003862	putative metal binding site [ion binding]; other site
1116391003863	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391003864	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391003865	dimer interface [polypeptide binding]; other site
1116391003866	phosphorylation site [posttranslational modification]
1116391003867	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391003868	ATP binding site [chemical binding]; other site
1116391003869	Mg2+ binding site [ion binding]; other site
1116391003870	G-X-G motif; other site
1116391003871	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1116391003872	Domain of unknown function (DUF1805); Region: DUF1805; cl01339
1116391003873	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1116391003874	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391003875	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1116391003876	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1116391003877	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391003878	DNA-binding site [nucleotide binding]; DNA binding site
1116391003879	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1116391003880	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1116391003881	nudix motif; other site
1116391003882	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1116391003883	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391003884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391003885	Coenzyme A binding pocket [chemical binding]; other site
1116391003886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391003887	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
1116391003888	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1116391003889	active site
1116391003890	putative substrate binding pocket [chemical binding]; other site
1116391003891	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1116391003892	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1116391003893	Protein of unknown function DUF58; Region: DUF58; pfam01882
1116391003894	MoxR-like ATPases [General function prediction only]; Region: COG0714
1116391003895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391003896	Walker A motif; other site
1116391003897	ATP binding site [chemical binding]; other site
1116391003898	Walker B motif; other site
1116391003899	arginine finger; other site
1116391003900	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1116391003901	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1116391003902	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1116391003903	active site
1116391003904	Zn binding site [ion binding]; other site
1116391003905	S-layer homology domain; Region: SLH; pfam00395
1116391003906	S-layer homology domain; Region: SLH; pfam00395
1116391003907	S-layer homology domain; Region: SLH; pfam00395
1116391003908	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1116391003909	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1116391003910	Bacterial transcriptional regulator; Region: IclR; pfam01614
1116391003911	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391003912	classical (c) SDRs; Region: SDR_c; cd05233
1116391003913	NAD(P) binding site [chemical binding]; other site
1116391003914	active site
1116391003915	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1116391003916	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1116391003917	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1116391003918	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1116391003919	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391003920	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391003921	NAD(P) binding site [chemical binding]; other site
1116391003922	active site
1116391003923	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1116391003924	Amidohydrolase; Region: Amidohydro_4; pfam13147
1116391003925	active site
1116391003926	dimer interface [polypeptide binding]; other site
1116391003927	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1116391003928	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1116391003929	active site
1116391003930	trimer interface [polypeptide binding]; other site
1116391003931	allosteric site; other site
1116391003932	active site lid [active]
1116391003933	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1116391003934	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1116391003935	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1116391003936	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1116391003937	putative active site [active]
1116391003938	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1116391003939	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1116391003940	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1116391003941	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1116391003942	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1116391003943	putative active site [active]
1116391003944	putative NTP binding site [chemical binding]; other site
1116391003945	putative nucleic acid binding site [nucleotide binding]; other site
1116391003946	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1116391003947	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
1116391003948	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1116391003949	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1116391003950	Walker A/P-loop; other site
1116391003951	ATP binding site [chemical binding]; other site
1116391003952	Q-loop/lid; other site
1116391003953	ABC transporter signature motif; other site
1116391003954	Walker B; other site
1116391003955	D-loop; other site
1116391003956	H-loop/switch region; other site
1116391003957	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1116391003958	FeS assembly protein SufD; Region: sufD; TIGR01981
1116391003959	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1116391003960	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1116391003961	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391003962	catalytic residue [active]
1116391003963	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1116391003964	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1116391003965	trimerization site [polypeptide binding]; other site
1116391003966	active site
1116391003967	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1116391003968	FeS assembly protein SufB; Region: sufB; TIGR01980
1116391003969	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1116391003970	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1116391003971	Int/Topo IB signature motif; other site
1116391003972	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1116391003973	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
1116391003974	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
1116391003975	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391003976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391003977	non-specific DNA binding site [nucleotide binding]; other site
1116391003978	salt bridge; other site
1116391003979	sequence-specific DNA binding site [nucleotide binding]; other site
1116391003980	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391003981	non-specific DNA binding site [nucleotide binding]; other site
1116391003982	salt bridge; other site
1116391003983	sequence-specific DNA binding site [nucleotide binding]; other site
1116391003984	Domain of unknown function (DUF771); Region: DUF771; cl09962
1116391003985	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391003986	non-specific DNA binding site [nucleotide binding]; other site
1116391003987	salt bridge; other site
1116391003988	sequence-specific DNA binding site [nucleotide binding]; other site
1116391003989	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1116391003990	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1116391003991	RecT family; Region: RecT; cl04285
1116391003992	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
1116391003993	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1116391003994	replicative DNA helicase; Region: DnaB; TIGR00665
1116391003995	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1116391003996	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1116391003997	Walker A motif; other site
1116391003998	ATP binding site [chemical binding]; other site
1116391003999	Walker B motif; other site
1116391004000	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
1116391004001	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1116391004002	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1116391004003	active site
1116391004004	Phage terminase, small subunit; Region: Terminase_4; pfam05119
1116391004005	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1116391004006	Phage-related protein [Function unknown]; Region: COG4695
1116391004007	Phage portal protein; Region: Phage_portal; pfam04860
1116391004008	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
1116391004009	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1116391004010	Phage capsid family; Region: Phage_capsid; pfam05065
1116391004011	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1116391004012	oligomerization interface [polypeptide binding]; other site
1116391004013	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1116391004014	Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883
1116391004015	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1116391004016	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1116391004017	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1116391004018	active site
1116391004019	catalytic triad [active]
1116391004020	oxyanion hole [active]
1116391004021	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391004022	Interdomain contacts; other site
1116391004023	Cytokine receptor motif; other site
1116391004024	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
1116391004025	Phage-related protein [Function unknown]; Region: COG5412
1116391004026	Phage tail protein; Region: Sipho_tail; cl17486
1116391004027	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1116391004028	substrate binding site [chemical binding]; other site
1116391004029	amidase catalytic site [active]
1116391004030	Zn binding residues [ion binding]; other site
1116391004031	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391004032	Cupin; Region: Cupin_1; smart00835
1116391004033	Transmembrane protein; Region: Macoilin; pfam09726
1116391004034	Helix-turn-helix domain; Region: HTH_36; pfam13730
1116391004035	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1116391004036	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1116391004037	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1116391004038	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1116391004039	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1116391004040	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1116391004041	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1116391004042	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1116391004043	Ligand Binding Site [chemical binding]; other site
1116391004044	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1116391004045	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1116391004046	Ligand Binding Site [chemical binding]; other site
1116391004047	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1116391004048	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1116391004049	GAF domain; Region: GAF_3; pfam13492
1116391004050	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391004051	dimer interface [polypeptide binding]; other site
1116391004052	phosphorylation site [posttranslational modification]
1116391004053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004054	ATP binding site [chemical binding]; other site
1116391004055	Mg2+ binding site [ion binding]; other site
1116391004056	G-X-G motif; other site
1116391004057	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1116391004058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004059	active site
1116391004060	phosphorylation site [posttranslational modification]
1116391004061	intermolecular recognition site; other site
1116391004062	dimerization interface [polypeptide binding]; other site
1116391004063	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391004064	DNA binding site [nucleotide binding]
1116391004065	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391004066	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391004067	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1116391004068	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1116391004069	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1116391004070	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391004071	Walker A/P-loop; other site
1116391004072	ATP binding site [chemical binding]; other site
1116391004073	Q-loop/lid; other site
1116391004074	ABC transporter signature motif; other site
1116391004075	Walker B; other site
1116391004076	D-loop; other site
1116391004077	H-loop/switch region; other site
1116391004078	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1116391004079	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1116391004080	MULE transposase domain; Region: MULE; pfam10551
1116391004081	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391004082	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391004083	DNA binding residues [nucleotide binding]
1116391004084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391004085	NmrA-like family; Region: NmrA; pfam05368
1116391004086	NAD(P) binding site [chemical binding]; other site
1116391004087	active site
1116391004088	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1116391004089	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391004090	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391004091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391004092	NAD(P) binding site [chemical binding]; other site
1116391004093	active site
1116391004094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391004095	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391004096	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391004097	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391004098	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391004099	Transposase; Region: HTH_Tnp_1; cl17663
1116391004100	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391004101	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391004102	HTH-like domain; Region: HTH_21; pfam13276
1116391004103	Integrase core domain; Region: rve; pfam00665
1116391004104	Integrase core domain; Region: rve_2; pfam13333
1116391004105	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391004106	classical (c) SDRs; Region: SDR_c; cd05233
1116391004107	NAD(P) binding site [chemical binding]; other site
1116391004108	active site
1116391004109	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1116391004110	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1116391004111	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391004112	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391004113	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1116391004114	Aspartase; Region: Aspartase; cd01357
1116391004115	active sites [active]
1116391004116	tetramer interface [polypeptide binding]; other site
1116391004117	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1116391004118	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1116391004119	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1116391004120	active site
1116391004121	homotetramer interface [polypeptide binding]; other site
1116391004122	homodimer interface [polypeptide binding]; other site
1116391004123	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1116391004124	dimerization interface [polypeptide binding]; other site
1116391004125	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
1116391004126	mannose binding site [chemical binding]; other site
1116391004127	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391004128	MarR family; Region: MarR; pfam01047
1116391004129	active site
1116391004130	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1116391004131	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1116391004132	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1116391004133	NAD binding site [chemical binding]; other site
1116391004134	substrate binding site [chemical binding]; other site
1116391004135	putative active site [active]
1116391004136	hypothetical protein; Validated; Region: PRK07581
1116391004137	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1116391004138	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391004139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391004140	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391004141	dimerization interface [polypeptide binding]; other site
1116391004142	hypothetical protein; Provisional; Region: PRK06184
1116391004143	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1116391004144	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1116391004145	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1116391004146	conserved cys residue [active]
1116391004147	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1116391004148	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391004149	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391004150	putative substrate translocation pore; other site
1116391004151	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391004152	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391004153	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391004154	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391004155	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
1116391004156	putative hydrophobic ligand binding site [chemical binding]; other site
1116391004157	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391004158	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391004159	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391004160	dimerization interface [polypeptide binding]; other site
1116391004161	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1116391004162	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1116391004163	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391004164	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391004165	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391004166	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1116391004167	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391004168	Zn2+ binding site [ion binding]; other site
1116391004169	Mg2+ binding site [ion binding]; other site
1116391004170	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1116391004171	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1116391004172	ATP binding site [chemical binding]; other site
1116391004173	substrate interface [chemical binding]; other site
1116391004174	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1116391004175	MoaE interaction surface [polypeptide binding]; other site
1116391004176	MoeB interaction surface [polypeptide binding]; other site
1116391004177	thiocarboxylated glycine; other site
1116391004178	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1116391004179	MoaE homodimer interface [polypeptide binding]; other site
1116391004180	MoaD interaction [polypeptide binding]; other site
1116391004181	active site residues [active]
1116391004182	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1116391004183	Moco binding site; other site
1116391004184	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1116391004185	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391004186	active site
1116391004187	metal binding site [ion binding]; metal-binding site
1116391004188	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1116391004189	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1116391004190	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391004191	FeS/SAM binding site; other site
1116391004192	YfkB-like domain; Region: YfkB; pfam08756
1116391004193	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1116391004194	Domain of unknown function DUF21; Region: DUF21; pfam01595
1116391004195	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1116391004196	Transporter associated domain; Region: CorC_HlyC; smart01091
1116391004197	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1116391004198	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1116391004199	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391004200	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391004201	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391004202	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1116391004203	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1116391004204	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391004205	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391004206	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1116391004207	CotJB protein; Region: CotJB; pfam12652
1116391004208	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1116391004209	dinuclear metal binding motif [ion binding]; other site
1116391004210	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391004211	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391004212	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
1116391004213	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1116391004214	dinuclear metal binding motif [ion binding]; other site
1116391004215	Protein of unknown function (DUF975); Region: DUF975; cl10504
1116391004216	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1116391004217	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391004218	motif II; other site
1116391004219	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391004220	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391004221	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391004222	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391004223	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391004224	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1116391004225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391004226	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1116391004227	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1116391004228	hypothetical protein; Provisional; Region: PRK07236
1116391004229	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1116391004230	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391004231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391004232	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391004233	MarR family; Region: MarR_2; pfam12802
1116391004234	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1116391004235	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1116391004236	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391004237	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1116391004238	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391004239	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1116391004240	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391004241	DNA-binding site [nucleotide binding]; DNA binding site
1116391004242	DRTGG domain; Region: DRTGG; pfam07085
1116391004243	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1116391004244	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1116391004245	active site 2 [active]
1116391004246	active site 1 [active]
1116391004247	YtpI-like protein; Region: YtpI; pfam14007
1116391004248	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
1116391004249	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
1116391004250	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1116391004251	active site
1116391004252	PHP Thumb interface [polypeptide binding]; other site
1116391004253	metal binding site [ion binding]; metal-binding site
1116391004254	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1116391004255	generic binding surface II; other site
1116391004256	generic binding surface I; other site
1116391004257	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1116391004258	tetramer interfaces [polypeptide binding]; other site
1116391004259	binuclear metal-binding site [ion binding]; other site
1116391004260	Flavodoxin domain; Region: Flavodoxin_5; cl17428
1116391004261	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1116391004262	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1116391004263	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1116391004264	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1116391004265	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1116391004266	pyruvate kinase; Provisional; Region: PRK06354
1116391004267	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1116391004268	domain interfaces; other site
1116391004269	active site
1116391004270	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1116391004271	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1116391004272	active site
1116391004273	polyphosphate kinase; Provisional; Region: PRK05443
1116391004274	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1116391004275	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1116391004276	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1116391004277	putative domain interface [polypeptide binding]; other site
1116391004278	putative active site [active]
1116391004279	catalytic site [active]
1116391004280	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1116391004281	putative domain interface [polypeptide binding]; other site
1116391004282	putative active site [active]
1116391004283	catalytic site [active]
1116391004284	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1116391004285	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1116391004286	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1116391004287	dimer interface [polypeptide binding]; other site
1116391004288	Citrate synthase; Region: Citrate_synt; pfam00285
1116391004289	active site
1116391004290	citrylCoA binding site [chemical binding]; other site
1116391004291	oxalacetate/citrate binding site [chemical binding]; other site
1116391004292	coenzyme A binding site [chemical binding]; other site
1116391004293	catalytic triad [active]
1116391004294	isocitrate dehydrogenase; Validated; Region: PRK06451
1116391004295	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1116391004296	malate dehydrogenase; Reviewed; Region: PRK06223
1116391004297	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1116391004298	NAD(P) binding site [chemical binding]; other site
1116391004299	dimer interface [polypeptide binding]; other site
1116391004300	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391004301	substrate binding site [chemical binding]; other site
1116391004302	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1116391004303	5'-nucleotidase; Provisional; Region: PRK03826
1116391004304	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1116391004305	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1116391004306	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1116391004307	Sodium Bile acid symporter family; Region: SBF; cl17470
1116391004308	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1116391004309	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391004310	dimerization interface [polypeptide binding]; other site
1116391004311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391004312	putative active site [active]
1116391004313	heme pocket [chemical binding]; other site
1116391004314	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391004315	dimer interface [polypeptide binding]; other site
1116391004316	phosphorylation site [posttranslational modification]
1116391004317	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004318	ATP binding site [chemical binding]; other site
1116391004319	Mg2+ binding site [ion binding]; other site
1116391004320	G-X-G motif; other site
1116391004321	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391004322	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004323	active site
1116391004324	phosphorylation site [posttranslational modification]
1116391004325	intermolecular recognition site; other site
1116391004326	dimerization interface [polypeptide binding]; other site
1116391004327	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391004328	DNA binding site [nucleotide binding]
1116391004329	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391004330	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391004331	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391004332	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391004333	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391004334	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391004335	CHASE3 domain; Region: CHASE3; cl05000
1116391004336	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391004337	dimerization interface [polypeptide binding]; other site
1116391004338	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391004339	dimer interface [polypeptide binding]; other site
1116391004340	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1116391004341	putative CheW interface [polypeptide binding]; other site
1116391004342	PBP superfamily domain; Region: PBP_like_2; cl17296
1116391004343	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1116391004344	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1116391004345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391004346	dimer interface [polypeptide binding]; other site
1116391004347	conserved gate region; other site
1116391004348	putative PBP binding loops; other site
1116391004349	ABC-ATPase subunit interface; other site
1116391004350	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1116391004351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391004352	dimer interface [polypeptide binding]; other site
1116391004353	conserved gate region; other site
1116391004354	putative PBP binding loops; other site
1116391004355	ABC-ATPase subunit interface; other site
1116391004356	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1116391004357	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1116391004358	Walker A/P-loop; other site
1116391004359	ATP binding site [chemical binding]; other site
1116391004360	Q-loop/lid; other site
1116391004361	ABC transporter signature motif; other site
1116391004362	Walker B; other site
1116391004363	D-loop; other site
1116391004364	H-loop/switch region; other site
1116391004365	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1116391004366	PhoU domain; Region: PhoU; pfam01895
1116391004367	PhoU domain; Region: PhoU; pfam01895
1116391004368	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1116391004369	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391004370	motif II; other site
1116391004371	DNA polymerase I; Provisional; Region: PRK05755
1116391004372	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1116391004373	active site
1116391004374	metal binding site 1 [ion binding]; metal-binding site
1116391004375	putative 5' ssDNA interaction site; other site
1116391004376	metal binding site 3; metal-binding site
1116391004377	metal binding site 2 [ion binding]; metal-binding site
1116391004378	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1116391004379	putative DNA binding site [nucleotide binding]; other site
1116391004380	putative metal binding site [ion binding]; other site
1116391004381	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1116391004382	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1116391004383	active site
1116391004384	DNA binding site [nucleotide binding]
1116391004385	catalytic site [active]
1116391004386	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
1116391004387	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1116391004388	DNA binding site [nucleotide binding]
1116391004389	catalytic residue [active]
1116391004390	H2TH interface [polypeptide binding]; other site
1116391004391	putative catalytic residues [active]
1116391004392	turnover-facilitating residue; other site
1116391004393	intercalation triad [nucleotide binding]; other site
1116391004394	8OG recognition residue [nucleotide binding]; other site
1116391004395	putative reading head residues; other site
1116391004396	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1116391004397	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1116391004398	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1116391004399	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1116391004400	CoA-binding site [chemical binding]; other site
1116391004401	ATP-binding [chemical binding]; other site
1116391004402	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1116391004403	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1116391004404	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1116391004405	catalytic residue [active]
1116391004406	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1116391004407	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1116391004408	ATP cone domain; Region: ATP-cone; pfam03477
1116391004409	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1116391004410	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1116391004411	Predicted flavoprotein [General function prediction only]; Region: COG0431
1116391004412	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391004413	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391004414	dimerization interface [polypeptide binding]; other site
1116391004415	putative DNA binding site [nucleotide binding]; other site
1116391004416	Winged helix-turn helix; Region: HTH_29; pfam13551
1116391004417	putative Zn2+ binding site [ion binding]; other site
1116391004418	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1116391004419	putative hydrophobic ligand binding site [chemical binding]; other site
1116391004420	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391004421	MarR family; Region: MarR_2; pfam12802
1116391004422	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391004423	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391004424	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1116391004425	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
1116391004426	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1116391004427	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1116391004428	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1116391004429	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391004430	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391004431	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1116391004432	putative NAD(P) binding site [chemical binding]; other site
1116391004433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391004434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391004435	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391004436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391004437	Coenzyme A binding pocket [chemical binding]; other site
1116391004438	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391004439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004440	active site
1116391004441	phosphorylation site [posttranslational modification]
1116391004442	intermolecular recognition site; other site
1116391004443	dimerization interface [polypeptide binding]; other site
1116391004444	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391004445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391004446	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391004447	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391004448	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391004449	dimerization interface [polypeptide binding]; other site
1116391004450	Histidine kinase; Region: His_kinase; pfam06580
1116391004451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004452	ATP binding site [chemical binding]; other site
1116391004453	Mg2+ binding site [ion binding]; other site
1116391004454	G-X-G motif; other site
1116391004455	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391004456	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391004457	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391004458	dimer interface [polypeptide binding]; other site
1116391004459	conserved gate region; other site
1116391004460	putative PBP binding loops; other site
1116391004461	ABC-ATPase subunit interface; other site
1116391004462	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391004463	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1116391004464	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391004465	dimer interface [polypeptide binding]; other site
1116391004466	conserved gate region; other site
1116391004467	putative PBP binding loops; other site
1116391004468	ABC-ATPase subunit interface; other site
1116391004469	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1116391004470	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
1116391004471	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1116391004472	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1116391004473	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1116391004474	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1116391004475	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
1116391004476	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391004477	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1116391004478	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391004479	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1116391004480	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391004481	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391004482	Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335
1116391004483	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1116391004484	active site residue [active]
1116391004485	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1116391004486	putative homodimer interface [polypeptide binding]; other site
1116391004487	putative homotetramer interface [polypeptide binding]; other site
1116391004488	putative metal binding site [ion binding]; other site
1116391004489	putative homodimer-homodimer interface [polypeptide binding]; other site
1116391004490	putative allosteric switch controlling residues; other site
1116391004491	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1116391004492	active site residue [active]
1116391004493	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1116391004494	CPxP  motif; other site
1116391004495	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1116391004496	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1116391004497	CPxP  motif; other site
1116391004498	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1116391004499	active site residue [active]
1116391004500	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1116391004501	active site residue [active]
1116391004502	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391004503	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1116391004504	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391004505	Interdomain contacts; other site
1116391004506	Cytokine receptor motif; other site
1116391004507	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391004508	Interdomain contacts; other site
1116391004509	Cytokine receptor motif; other site
1116391004510	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391004511	dockerin binding interface; other site
1116391004512	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1116391004513	Cation efflux family; Region: Cation_efflux; pfam01545
1116391004514	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391004515	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1116391004516	nudix motif; other site
1116391004517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391004518	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391004519	putative substrate translocation pore; other site
1116391004520	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1116391004521	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1116391004522	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1116391004523	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391004524	NAD(P) binding site [chemical binding]; other site
1116391004525	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1116391004526	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1116391004527	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391004528	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391004529	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391004530	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391004531	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391004532	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391004533	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1116391004534	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391004535	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1116391004536	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391004537	HTH domain; Region: HTH_11; pfam08279
1116391004538	WYL domain; Region: WYL; pfam13280
1116391004539	short chain dehydrogenase; Provisional; Region: PRK12939
1116391004540	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1116391004541	NADP binding site [chemical binding]; other site
1116391004542	homodimer interface [polypeptide binding]; other site
1116391004543	active site
1116391004544	substrate binding site [chemical binding]; other site
1116391004545	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
1116391004546	putative dimer interface [polypeptide binding]; other site
1116391004547	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391004548	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1116391004549	active site 1 [active]
1116391004550	dimer interface [polypeptide binding]; other site
1116391004551	hexamer interface [polypeptide binding]; other site
1116391004552	active site 2 [active]
1116391004553	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1116391004554	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391004555	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391004556	short chain dehydrogenase; Validated; Region: PRK08264
1116391004557	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391004558	NAD(P) binding site [chemical binding]; other site
1116391004559	active site
1116391004560	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1116391004561	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391004562	NAD(P) binding site [chemical binding]; other site
1116391004563	active site
1116391004564	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1116391004565	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391004566	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1116391004567	putative NAD(P) binding site [chemical binding]; other site
1116391004568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391004569	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391004570	putative substrate translocation pore; other site
1116391004571	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391004572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391004573	S-adenosylmethionine binding site [chemical binding]; other site
1116391004574	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391004575	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1116391004576	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391004577	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1116391004578	Histidine kinase; Region: HisKA_3; pfam07730
1116391004579	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1116391004580	ATP binding site [chemical binding]; other site
1116391004581	Mg2+ binding site [ion binding]; other site
1116391004582	G-X-G motif; other site
1116391004583	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391004584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004585	active site
1116391004586	phosphorylation site [posttranslational modification]
1116391004587	intermolecular recognition site; other site
1116391004588	dimerization interface [polypeptide binding]; other site
1116391004589	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391004590	DNA binding residues [nucleotide binding]
1116391004591	dimerization interface [polypeptide binding]; other site
1116391004592	DoxX-like family; Region: DoxX_2; pfam13564
1116391004593	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391004594	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1116391004595	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391004596	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391004597	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391004598	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391004599	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391004600	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
1116391004601	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1116391004602	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391004603	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1116391004604	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1116391004605	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1116391004606	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1116391004607	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1116391004608	regulatory protein interface [polypeptide binding]; other site
1116391004609	active site
1116391004610	regulatory phosphorylation site [posttranslational modification]; other site
1116391004611	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391004612	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1116391004613	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1116391004614	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391004615	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391004616	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391004617	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391004618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391004619	putative substrate translocation pore; other site
1116391004620	Cache domain; Region: Cache_1; pfam02743
1116391004621	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391004622	Histidine kinase; Region: His_kinase; pfam06580
1116391004623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004624	ATP binding site [chemical binding]; other site
1116391004625	Mg2+ binding site [ion binding]; other site
1116391004626	G-X-G motif; other site
1116391004627	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391004628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004629	active site
1116391004630	phosphorylation site [posttranslational modification]
1116391004631	intermolecular recognition site; other site
1116391004632	dimerization interface [polypeptide binding]; other site
1116391004633	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391004634	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391004635	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
1116391004636	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391004637	NodB motif; other site
1116391004638	putative active site [active]
1116391004639	putative catalytic site [active]
1116391004640	putative Zn binding site [ion binding]; other site
1116391004641	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391004642	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391004643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391004644	dimer interface [polypeptide binding]; other site
1116391004645	conserved gate region; other site
1116391004646	putative PBP binding loops; other site
1116391004647	ABC-ATPase subunit interface; other site
1116391004648	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391004649	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391004650	dimer interface [polypeptide binding]; other site
1116391004651	conserved gate region; other site
1116391004652	putative PBP binding loops; other site
1116391004653	ABC-ATPase subunit interface; other site
1116391004654	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
1116391004655	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1116391004656	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1116391004657	heme-binding site [chemical binding]; other site
1116391004658	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1116391004659	FAD binding pocket [chemical binding]; other site
1116391004660	FAD binding motif [chemical binding]; other site
1116391004661	phosphate binding motif [ion binding]; other site
1116391004662	beta-alpha-beta structure motif; other site
1116391004663	NAD binding pocket [chemical binding]; other site
1116391004664	Heme binding  pocket [chemical binding]; other site
1116391004665	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391004666	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391004667	ligand binding site [chemical binding]; other site
1116391004668	flexible hinge region; other site
1116391004669	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1116391004670	non-specific DNA interactions [nucleotide binding]; other site
1116391004671	DNA binding site [nucleotide binding]
1116391004672	sequence specific DNA binding site [nucleotide binding]; other site
1116391004673	putative cAMP binding site [chemical binding]; other site
1116391004674	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391004675	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391004676	Pyruvate formate lyase 1; Region: PFL1; cd01678
1116391004677	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1116391004678	coenzyme A binding site [chemical binding]; other site
1116391004679	active site
1116391004680	catalytic residues [active]
1116391004681	glycine loop; other site
1116391004682	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1116391004683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391004684	FeS/SAM binding site; other site
1116391004685	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1116391004686	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1116391004687	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1116391004688	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
1116391004689	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1116391004690	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1116391004691	[4Fe-4S] binding site [ion binding]; other site
1116391004692	molybdopterin cofactor binding site; other site
1116391004693	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1116391004694	molybdopterin cofactor binding site; other site
1116391004695	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1116391004696	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1116391004697	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1116391004698	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1116391004699	iron-sulfur cluster [ion binding]; other site
1116391004700	[2Fe-2S] cluster binding site [ion binding]; other site
1116391004701	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
1116391004702	putative hydrophobic ligand binding site [chemical binding]; other site
1116391004703	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1116391004704	putative hydrophobic ligand binding site [chemical binding]; other site
1116391004705	hydroxylamine reductase; Provisional; Region: PRK12310
1116391004706	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1116391004707	ACS interaction site; other site
1116391004708	CODH interaction site; other site
1116391004709	metal cluster binding site [ion binding]; other site
1116391004710	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391004711	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391004712	ligand binding site [chemical binding]; other site
1116391004713	flexible hinge region; other site
1116391004714	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1116391004715	non-specific DNA interactions [nucleotide binding]; other site
1116391004716	DNA binding site [nucleotide binding]
1116391004717	sequence specific DNA binding site [nucleotide binding]; other site
1116391004718	putative cAMP binding site [chemical binding]; other site
1116391004719	GAF domain; Region: GAF; pfam01590
1116391004720	GAF domain; Region: GAF_2; pfam13185
1116391004721	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391004722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004723	active site
1116391004724	phosphorylation site [posttranslational modification]
1116391004725	intermolecular recognition site; other site
1116391004726	dimerization interface [polypeptide binding]; other site
1116391004727	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391004728	DNA binding residues [nucleotide binding]
1116391004729	dimerization interface [polypeptide binding]; other site
1116391004730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391004731	PAS domain; Region: PAS_9; pfam13426
1116391004732	putative active site [active]
1116391004733	heme pocket [chemical binding]; other site
1116391004734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1116391004735	Histidine kinase; Region: HisKA_3; pfam07730
1116391004736	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004737	ATP binding site [chemical binding]; other site
1116391004738	Mg2+ binding site [ion binding]; other site
1116391004739	G-X-G motif; other site
1116391004740	Hemerythrin family; Region: Hemerythrin-like; cl15774
1116391004741	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1116391004742	30S subunit binding site; other site
1116391004743	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1116391004744	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1116391004745	putative catalytic cysteine [active]
1116391004746	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1116391004747	putative active site [active]
1116391004748	metal binding site [ion binding]; metal-binding site
1116391004749	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1116391004750	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391004751	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391004752	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1116391004753	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1116391004754	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1116391004755	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1116391004756	iron-sulfur cluster [ion binding]; other site
1116391004757	[2Fe-2S] cluster binding site [ion binding]; other site
1116391004758	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1116391004759	GTP binding site; other site
1116391004760	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1116391004761	dimerization interface [polypeptide binding]; other site
1116391004762	active site
1116391004763	PAS fold; Region: PAS_4; pfam08448
1116391004764	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1116391004765	putative active site [active]
1116391004766	heme pocket [chemical binding]; other site
1116391004767	PAS domain S-box; Region: sensory_box; TIGR00229
1116391004768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391004769	putative active site [active]
1116391004770	heme pocket [chemical binding]; other site
1116391004771	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391004772	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391004773	metal binding site [ion binding]; metal-binding site
1116391004774	active site
1116391004775	I-site; other site
1116391004776	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391004777	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
1116391004778	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1116391004779	active sites [active]
1116391004780	tetramer interface [polypeptide binding]; other site
1116391004781	urocanate hydratase; Provisional; Region: PRK05414
1116391004782	imidazolonepropionase; Validated; Region: PRK09356
1116391004783	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1116391004784	active site
1116391004785	allantoate amidohydrolase; Reviewed; Region: PRK09290
1116391004786	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1116391004787	active site
1116391004788	metal binding site [ion binding]; metal-binding site
1116391004789	dimer interface [polypeptide binding]; other site
1116391004790	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1116391004791	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
1116391004792	active site
1116391004793	putative substrate binding pocket [chemical binding]; other site
1116391004794	Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373
1116391004795	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
1116391004796	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
1116391004797	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1116391004798	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1116391004799	active site
1116391004800	catalytic site [active]
1116391004801	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
1116391004802	EamA-like transporter family; Region: EamA; pfam00892
1116391004803	Amino acid permease; Region: AA_permease_2; pfam13520
1116391004804	K+ potassium transporter; Region: K_trans; cl15781
1116391004805	Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373
1116391004806	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
1116391004807	starch-binding site 2 [chemical binding]; other site
1116391004808	starch-binding site 1 [chemical binding]; other site
1116391004809	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
1116391004810	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1116391004811	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1116391004812	putative ligand binding site [chemical binding]; other site
1116391004813	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1116391004814	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391004815	Walker A/P-loop; other site
1116391004816	ATP binding site [chemical binding]; other site
1116391004817	Q-loop/lid; other site
1116391004818	ABC transporter signature motif; other site
1116391004819	Walker B; other site
1116391004820	D-loop; other site
1116391004821	H-loop/switch region; other site
1116391004822	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391004823	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391004824	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391004825	TM-ABC transporter signature motif; other site
1116391004826	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391004827	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391004828	TM-ABC transporter signature motif; other site
1116391004829	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1116391004830	nucleoside/Zn binding site; other site
1116391004831	dimer interface [polypeptide binding]; other site
1116391004832	catalytic motif [active]
1116391004833	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391004834	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391004835	dimer interface [polypeptide binding]; other site
1116391004836	putative CheW interface [polypeptide binding]; other site
1116391004837	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391004838	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391004839	DNA binding site [nucleotide binding]
1116391004840	domain linker motif; other site
1116391004841	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391004842	dimerization interface [polypeptide binding]; other site
1116391004843	ligand binding site [chemical binding]; other site
1116391004844	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391004845	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1116391004846	putative substrate binding site [chemical binding]; other site
1116391004847	putative ATP binding site [chemical binding]; other site
1116391004848	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1116391004849	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391004850	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1116391004851	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1116391004852	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391004853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004854	active site
1116391004855	phosphorylation site [posttranslational modification]
1116391004856	intermolecular recognition site; other site
1116391004857	dimerization interface [polypeptide binding]; other site
1116391004858	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391004859	DNA binding site [nucleotide binding]
1116391004860	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391004861	dimerization interface [polypeptide binding]; other site
1116391004862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391004863	dimer interface [polypeptide binding]; other site
1116391004864	phosphorylation site [posttranslational modification]
1116391004865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004866	ATP binding site [chemical binding]; other site
1116391004867	Mg2+ binding site [ion binding]; other site
1116391004868	G-X-G motif; other site
1116391004869	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1116391004870	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1116391004871	S-layer homology domain; Region: SLH; pfam00395
1116391004872	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1116391004873	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391004874	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1116391004875	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
1116391004876	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391004877	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391004878	metal binding site [ion binding]; metal-binding site
1116391004879	active site
1116391004880	I-site; other site
1116391004881	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391004882	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391004883	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1116391004884	Protein export membrane protein; Region: SecD_SecF; cl14618
1116391004885	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391004886	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391004887	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1116391004888	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1116391004889	putative active site [active]
1116391004890	putative metal binding site [ion binding]; other site
1116391004891	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391004892	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1116391004893	VanW like protein; Region: VanW; pfam04294
1116391004894	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1116391004895	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391004896	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391004897	Coenzyme A binding pocket [chemical binding]; other site
1116391004898	Cache domain; Region: Cache_1; pfam02743
1116391004899	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391004900	dimerization interface [polypeptide binding]; other site
1116391004901	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391004902	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391004903	dimer interface [polypeptide binding]; other site
1116391004904	putative CheW interface [polypeptide binding]; other site
1116391004905	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1116391004906	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1116391004907	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1116391004908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391004909	ATP binding site [chemical binding]; other site
1116391004910	ABC transporter; Region: ABC_tran; pfam00005
1116391004911	Q-loop/lid; other site
1116391004912	ABC transporter signature motif; other site
1116391004913	Walker B; other site
1116391004914	D-loop; other site
1116391004915	H-loop/switch region; other site
1116391004916	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1116391004917	DinB family; Region: DinB; cl17821
1116391004918	DinB superfamily; Region: DinB_2; pfam12867
1116391004919	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391004920	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391004921	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1116391004922	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391004923	DNA-binding site [nucleotide binding]; DNA binding site
1116391004924	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391004925	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
1116391004926	putative ligand binding site [chemical binding]; other site
1116391004927	putative dimerization interface [polypeptide binding]; other site
1116391004928	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1116391004929	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1116391004930	intersubunit interface [polypeptide binding]; other site
1116391004931	active site
1116391004932	Zn2+ binding site [ion binding]; other site
1116391004933	ribulokinase; Provisional; Region: PRK04123
1116391004934	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1116391004935	N- and C-terminal domain interface [polypeptide binding]; other site
1116391004936	active site
1116391004937	MgATP binding site [chemical binding]; other site
1116391004938	catalytic site [active]
1116391004939	metal binding site [ion binding]; metal-binding site
1116391004940	carbohydrate binding site [chemical binding]; other site
1116391004941	homodimer interface [polypeptide binding]; other site
1116391004942	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391004943	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391004944	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1116391004945	nucleotide binding site/active site [active]
1116391004946	HIT family signature motif; other site
1116391004947	catalytic residue [active]
1116391004948	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391004949	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1116391004950	FeS/SAM binding site; other site
1116391004951	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1116391004952	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391004953	MarR family; Region: MarR; pfam01047
1116391004954	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
1116391004955	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1116391004956	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1116391004957	nucleotide binding site [chemical binding]; other site
1116391004958	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1116391004959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391004960	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1116391004961	binding surface
1116391004962	TPR motif; other site
1116391004963	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391004964	binding surface
1116391004965	TPR motif; other site
1116391004966	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1116391004967	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1116391004968	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1116391004969	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1116391004970	dimer interface [polypeptide binding]; other site
1116391004971	substrate binding site [chemical binding]; other site
1116391004972	ATP binding site [chemical binding]; other site
1116391004973	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1116391004974	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391004975	putative DNA binding site [nucleotide binding]; other site
1116391004976	putative Zn2+ binding site [ion binding]; other site
1116391004977	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1116391004978	active site
1116391004979	catalytic residues [active]
1116391004980	metal binding site [ion binding]; metal-binding site
1116391004981	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1116391004982	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391004983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391004984	active site
1116391004985	phosphorylation site [posttranslational modification]
1116391004986	intermolecular recognition site; other site
1116391004987	dimerization interface [polypeptide binding]; other site
1116391004988	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391004989	DNA binding site [nucleotide binding]
1116391004990	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391004991	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391004992	dimerization interface [polypeptide binding]; other site
1116391004993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391004994	dimer interface [polypeptide binding]; other site
1116391004995	phosphorylation site [posttranslational modification]
1116391004996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391004997	ATP binding site [chemical binding]; other site
1116391004998	Mg2+ binding site [ion binding]; other site
1116391004999	G-X-G motif; other site
1116391005000	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1116391005001	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1116391005002	active site
1116391005003	intersubunit interface [polypeptide binding]; other site
1116391005004	catalytic residue [active]
1116391005005	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
1116391005006	YtxH-like protein; Region: YtxH; pfam12732
1116391005007	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391005008	LytTr DNA-binding domain; Region: LytTR; cl04498
1116391005009	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391005010	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391005011	metal binding site [ion binding]; metal-binding site
1116391005012	active site
1116391005013	I-site; other site
1116391005014	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391005015	Staphylococcal AgrD protein; Region: AgrD; cl05477
1116391005016	Accessory gene regulator B; Region: AgrB; cl01873
1116391005017	CAAX protease self-immunity; Region: Abi; pfam02517
1116391005018	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391005019	non-specific DNA binding site [nucleotide binding]; other site
1116391005020	salt bridge; other site
1116391005021	sequence-specific DNA binding site [nucleotide binding]; other site
1116391005022	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1116391005023	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1116391005024	Glucose dehydrogenase; Region: glucose_DH; cd08230
1116391005025	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391005026	NADP binding site [chemical binding]; other site
1116391005027	catalytic Zn binding site [ion binding]; other site
1116391005028	structural Zn binding site [ion binding]; other site
1116391005029	dimer interface [polypeptide binding]; other site
1116391005030	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391005031	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
1116391005032	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1116391005033	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1116391005034	S-layer homology domain; Region: SLH; pfam00395
1116391005035	S-layer homology domain; Region: SLH; pfam00395
1116391005036	Family description; Region: VCBS; pfam13517
1116391005037	Family description; Region: VCBS; pfam13517
1116391005038	Family description; Region: VCBS; pfam13517
1116391005039	Family description; Region: VCBS; pfam13517
1116391005040	Family description; Region: VCBS; pfam13517
1116391005041	Family description; Region: VCBS; pfam13517
1116391005042	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1116391005043	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005044	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005045	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005046	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005047	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1116391005048	alpha-galactosidase; Provisional; Region: PRK15076
1116391005049	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1116391005050	NAD binding site [chemical binding]; other site
1116391005051	sugar binding site [chemical binding]; other site
1116391005052	divalent metal binding site [ion binding]; other site
1116391005053	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391005054	dimer interface [polypeptide binding]; other site
1116391005055	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1116391005056	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1116391005057	NodB motif; other site
1116391005058	active site
1116391005059	catalytic site [active]
1116391005060	Cd binding site [ion binding]; other site
1116391005061	glutamate racemase; Provisional; Region: PRK00865
1116391005062	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391005063	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
1116391005064	putative active site [active]
1116391005065	Zn binding site [ion binding]; other site
1116391005066	Domain of unknown function (DUF377); Region: DUF377; pfam04041
1116391005067	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391005068	active site
1116391005069	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005070	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391005071	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005072	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1116391005073	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1116391005074	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391005075	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391005076	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1116391005077	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1116391005078	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391005079	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1116391005080	SdiA-regulated; Region: SdiA-regulated; cd09971
1116391005081	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391005082	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391005083	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1116391005084	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1116391005085	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1116391005086	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1116391005087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391005088	S-adenosylmethionine binding site [chemical binding]; other site
1116391005089	DinB family; Region: DinB; cl17821
1116391005090	DinB superfamily; Region: DinB_2; pfam12867
1116391005091	drug efflux system protein MdtG; Provisional; Region: PRK09874
1116391005092	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391005093	putative substrate translocation pore; other site
1116391005094	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1116391005095	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391005096	active site
1116391005097	metal binding site [ion binding]; metal-binding site
1116391005098	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1116391005099	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1116391005100	putative active site [active]
1116391005101	putative metal binding site [ion binding]; other site
1116391005102	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1116391005103	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1116391005104	Integral membrane protein DUF92; Region: DUF92; pfam01940
1116391005105	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1116391005106	oligoendopeptidase F; Region: pepF; TIGR00181
1116391005107	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1116391005108	active site
1116391005109	Zn binding site [ion binding]; other site
1116391005110	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1116391005111	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1116391005112	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1116391005113	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1116391005114	DNA-binding site [nucleotide binding]; DNA binding site
1116391005115	RNA-binding motif; other site
1116391005116	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1116391005117	FMN binding site [chemical binding]; other site
1116391005118	dimer interface [polypeptide binding]; other site
1116391005119	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1116391005120	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1116391005121	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1116391005122	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1116391005123	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391005124	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391005125	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1116391005126	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1116391005127	FtsX-like permease family; Region: FtsX; pfam02687
1116391005128	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391005129	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391005130	Walker A/P-loop; other site
1116391005131	ATP binding site [chemical binding]; other site
1116391005132	Q-loop/lid; other site
1116391005133	ABC transporter signature motif; other site
1116391005134	Walker B; other site
1116391005135	D-loop; other site
1116391005136	H-loop/switch region; other site
1116391005137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391005138	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391005139	putative substrate translocation pore; other site
1116391005140	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
1116391005141	6-phosphofructokinase; Provisional; Region: PRK03202
1116391005142	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1116391005143	active site
1116391005144	ADP/pyrophosphate binding site [chemical binding]; other site
1116391005145	dimerization interface [polypeptide binding]; other site
1116391005146	allosteric effector site; other site
1116391005147	fructose-1,6-bisphosphate binding site; other site
1116391005148	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
1116391005149	Predicted flavoprotein [General function prediction only]; Region: COG0431
1116391005150	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391005151	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1116391005152	ligand binding site [chemical binding]; other site
1116391005153	active site
1116391005154	UGI interface [polypeptide binding]; other site
1116391005155	catalytic site [active]
1116391005156	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
1116391005157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391005158	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391005159	putative substrate translocation pore; other site
1116391005160	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1116391005161	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1116391005162	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391005163	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391005164	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391005165	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391005166	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1116391005167	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1116391005168	helicase 45; Provisional; Region: PTZ00424
1116391005169	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1116391005170	ATP binding site [chemical binding]; other site
1116391005171	Mg++ binding site [ion binding]; other site
1116391005172	motif III; other site
1116391005173	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391005174	nucleotide binding region [chemical binding]; other site
1116391005175	ATP-binding site [chemical binding]; other site
1116391005176	Protein of unknown function, DUF624; Region: DUF624; cl02369
1116391005177	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1116391005178	active site
1116391005179	intersubunit interactions; other site
1116391005180	catalytic residue [active]
1116391005181	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1116391005182	N- and C-terminal domain interface [polypeptide binding]; other site
1116391005183	D-xylulose kinase; Region: XylB; TIGR01312
1116391005184	active site
1116391005185	MgATP binding site [chemical binding]; other site
1116391005186	catalytic site [active]
1116391005187	metal binding site [ion binding]; metal-binding site
1116391005188	xylulose binding site [chemical binding]; other site
1116391005189	homodimer interface [polypeptide binding]; other site
1116391005190	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1116391005191	non-specific DNA interactions [nucleotide binding]; other site
1116391005192	DNA binding site [nucleotide binding]
1116391005193	sequence specific DNA binding site [nucleotide binding]; other site
1116391005194	putative cAMP binding site [chemical binding]; other site
1116391005195	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1116391005196	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1116391005197	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1116391005198	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
1116391005199	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1116391005200	dimer interface [polypeptide binding]; other site
1116391005201	catalytic triad [active]
1116391005202	peroxidatic and resolving cysteines [active]
1116391005203	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391005204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391005205	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1116391005206	putative dimerization interface [polypeptide binding]; other site
1116391005207	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1116391005208	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1116391005209	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1116391005210	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1116391005211	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
1116391005212	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391005213	DNA binding residues [nucleotide binding]
1116391005214	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1116391005215	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1116391005216	metal binding triad; other site
1116391005217	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
1116391005218	hypothetical protein; Provisional; Region: PRK07740
1116391005219	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1116391005220	active site
1116391005221	catalytic site [active]
1116391005222	substrate binding site [chemical binding]; other site
1116391005223	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1116391005224	MPN+ (JAMM) motif; other site
1116391005225	Zinc-binding site [ion binding]; other site
1116391005226	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391005227	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391005228	putative substrate translocation pore; other site
1116391005229	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1116391005230	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391005231	catalytic residues [active]
1116391005232	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1116391005233	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1116391005234	active site
1116391005235	catalytic residues [active]
1116391005236	metal binding site [ion binding]; metal-binding site
1116391005237	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1116391005238	DNA polymerase IV; Validated; Region: PRK01810
1116391005239	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1116391005240	active site
1116391005241	DNA binding site [nucleotide binding]
1116391005242	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1116391005243	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1116391005244	Walker A motif; other site
1116391005245	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1116391005246	CHASE2 domain; Region: CHASE2; pfam05226
1116391005247	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1116391005248	cyclase homology domain; Region: CHD; cd07302
1116391005249	nucleotidyl binding site; other site
1116391005250	metal binding site [ion binding]; metal-binding site
1116391005251	dimer interface [polypeptide binding]; other site
1116391005252	FecR protein; Region: FecR; pfam04773
1116391005253	NHL repeat; Region: NHL; pfam01436
1116391005254	NHL repeat; Region: NHL; pfam01436
1116391005255	NHL repeat; Region: NHL; pfam01436
1116391005256	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391005257	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1116391005258	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1116391005259	quinone interaction residues [chemical binding]; other site
1116391005260	active site
1116391005261	catalytic residues [active]
1116391005262	FMN binding site [chemical binding]; other site
1116391005263	substrate binding site [chemical binding]; other site
1116391005264	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1116391005265	synthetase active site [active]
1116391005266	NTP binding site [chemical binding]; other site
1116391005267	metal binding site [ion binding]; metal-binding site
1116391005268	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1116391005269	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391005270	catalytic residues [active]
1116391005271	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
1116391005272	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391005273	S-adenosylmethionine binding site [chemical binding]; other site
1116391005274	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1116391005275	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1116391005276	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391005277	RNA binding surface [nucleotide binding]; other site
1116391005278	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1116391005279	active site
1116391005280	uracil binding [chemical binding]; other site
1116391005281	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1116391005282	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391005283	active site
1116391005284	motif I; other site
1116391005285	motif II; other site
1116391005286	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1116391005287	CsbD-like; Region: CsbD; cl17424
1116391005288	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1116391005289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391005290	S-adenosylmethionine binding site [chemical binding]; other site
1116391005291	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1116391005292	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1116391005293	active site
1116391005294	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
1116391005295	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391005296	FeS/SAM binding site; other site
1116391005297	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1116391005298	Ligand Binding Site [chemical binding]; other site
1116391005299	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1116391005300	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391005301	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391005302	metal binding site [ion binding]; metal-binding site
1116391005303	active site
1116391005304	I-site; other site
1116391005305	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391005306	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391005307	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1116391005308	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391005309	NAD(P) binding site [chemical binding]; other site
1116391005310	active site
1116391005311	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1116391005312	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1116391005313	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391005314	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391005315	active site
1116391005316	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
1116391005317	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391005318	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391005319	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391005320	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1116391005321	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1116391005322	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1116391005323	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391005324	Coenzyme A binding pocket [chemical binding]; other site
1116391005325	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1116391005326	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1116391005327	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1116391005328	active site
1116391005329	HIGH motif; other site
1116391005330	KMSK motif region; other site
1116391005331	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1116391005332	tRNA binding surface [nucleotide binding]; other site
1116391005333	anticodon binding site; other site
1116391005334	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1116391005335	YqzE-like protein; Region: YqzE; pfam14038
1116391005336	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1116391005337	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1116391005338	transmembrane helices; other site
1116391005339	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
1116391005340	Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079
1116391005341	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1116391005342	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391005343	ATP binding site [chemical binding]; other site
1116391005344	putative Mg++ binding site [ion binding]; other site
1116391005345	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1116391005346	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391005347	nucleotide binding region [chemical binding]; other site
1116391005348	ATP-binding site [chemical binding]; other site
1116391005349	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1116391005350	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1116391005351	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1116391005352	homodimer interface [polypeptide binding]; other site
1116391005353	substrate-cofactor binding pocket; other site
1116391005354	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391005355	catalytic residue [active]
1116391005356	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1116391005357	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1116391005358	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1116391005359	active site
1116391005360	dimer interface [polypeptide binding]; other site
1116391005361	effector binding site; other site
1116391005362	TSCPD domain; Region: TSCPD; pfam12637
1116391005363	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
1116391005364	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1116391005365	dimerization interface [polypeptide binding]; other site
1116391005366	mannose binding site [chemical binding]; other site
1116391005367	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1116391005368	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
1116391005369	putative metal binding site [ion binding]; other site
1116391005370	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005371	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391005372	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005374	dimer interface [polypeptide binding]; other site
1116391005375	conserved gate region; other site
1116391005376	putative PBP binding loops; other site
1116391005377	ABC-ATPase subunit interface; other site
1116391005378	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391005379	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1116391005380	inhibitor binding site; inhibition site
1116391005381	active site
1116391005382	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1116391005383	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1116391005384	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
1116391005385	catalytic site [active]
1116391005386	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391005387	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391005388	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391005389	dimerization interface [polypeptide binding]; other site
1116391005390	Histidine kinase; Region: His_kinase; pfam06580
1116391005391	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391005392	ATP binding site [chemical binding]; other site
1116391005393	Mg2+ binding site [ion binding]; other site
1116391005394	G-X-G motif; other site
1116391005395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391005396	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391005397	active site
1116391005398	phosphorylation site [posttranslational modification]
1116391005399	intermolecular recognition site; other site
1116391005400	dimerization interface [polypeptide binding]; other site
1116391005401	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005402	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005404	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1116391005405	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005406	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005408	dimer interface [polypeptide binding]; other site
1116391005409	conserved gate region; other site
1116391005410	putative PBP binding loops; other site
1116391005411	ABC-ATPase subunit interface; other site
1116391005412	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005413	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005414	dimer interface [polypeptide binding]; other site
1116391005415	conserved gate region; other site
1116391005416	putative PBP binding loops; other site
1116391005417	ABC-ATPase subunit interface; other site
1116391005418	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005419	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391005420	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1116391005421	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005422	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005423	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1116391005424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1116391005425	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391005426	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
1116391005427	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391005428	dimerization interface [polypeptide binding]; other site
1116391005429	Histidine kinase; Region: His_kinase; pfam06580
1116391005430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391005431	ATP binding site [chemical binding]; other site
1116391005432	Mg2+ binding site [ion binding]; other site
1116391005433	G-X-G motif; other site
1116391005434	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391005435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391005436	active site
1116391005437	phosphorylation site [posttranslational modification]
1116391005438	intermolecular recognition site; other site
1116391005439	dimerization interface [polypeptide binding]; other site
1116391005440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005442	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005443	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391005444	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391005445	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391005446	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391005447	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391005448	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005449	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005450	dimer interface [polypeptide binding]; other site
1116391005451	conserved gate region; other site
1116391005452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391005453	ABC-ATPase subunit interface; other site
1116391005454	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005456	ABC-ATPase subunit interface; other site
1116391005457	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391005458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005459	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005461	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005462	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005463	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005464	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005465	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1116391005466	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005467	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005468	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005469	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391005470	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391005471	active site
1116391005472	catalytic tetrad [active]
1116391005473	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1116391005474	beta-D-glucuronidase; Provisional; Region: PRK10150
1116391005475	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391005476	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391005477	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391005478	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391005479	classical (c) SDRs; Region: SDR_c; cd05233
1116391005480	NAD(P) binding site [chemical binding]; other site
1116391005481	active site
1116391005482	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1116391005483	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391005484	NAD(P) binding site [chemical binding]; other site
1116391005485	active site
1116391005486	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005487	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005488	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005489	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005490	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391005491	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1116391005492	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1116391005493	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391005494	Interdomain contacts; other site
1116391005495	Cytokine receptor motif; other site
1116391005496	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391005497	Interdomain contacts; other site
1116391005498	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391005499	Interdomain contacts; other site
1116391005500	Cytokine receptor motif; other site
1116391005501	Melibiase; Region: Melibiase; pfam02065
1116391005502	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391005503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391005504	active site
1116391005505	phosphorylation site [posttranslational modification]
1116391005506	intermolecular recognition site; other site
1116391005507	dimerization interface [polypeptide binding]; other site
1116391005508	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005509	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391005511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391005512	dimerization interface [polypeptide binding]; other site
1116391005513	Histidine kinase; Region: His_kinase; pfam06580
1116391005514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391005515	ATP binding site [chemical binding]; other site
1116391005516	Mg2+ binding site [ion binding]; other site
1116391005517	G-X-G motif; other site
1116391005518	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005520	dimer interface [polypeptide binding]; other site
1116391005521	conserved gate region; other site
1116391005522	ABC-ATPase subunit interface; other site
1116391005523	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005525	ABC-ATPase subunit interface; other site
1116391005526	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005527	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1116391005528	Right handed beta helix region; Region: Beta_helix; pfam13229
1116391005529	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391005530	metal binding site [ion binding]; metal-binding site
1116391005531	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
1116391005532	Ca binding site [ion binding]; other site
1116391005533	Ca binding site (active) [ion binding]; other site
1116391005534	ligand binding site [chemical binding]; other site
1116391005535	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1116391005536	putative ligand binding site [chemical binding]; other site
1116391005537	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1116391005538	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1116391005539	Right handed beta helix region; Region: Beta_helix; pfam13229
1116391005540	Spore germination protein; Region: Spore_permease; cl17796
1116391005541	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391005542	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391005543	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1116391005544	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391005545	Cupin domain; Region: Cupin_2; pfam07883
1116391005546	Protein of unknown function (DUF1699); Region: DUF1699; pfam08004
1116391005547	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005549	FAD binding domain; Region: FAD_binding_1; pfam00667
1116391005550	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1116391005551	FAD binding pocket [chemical binding]; other site
1116391005552	FAD binding motif [chemical binding]; other site
1116391005553	catalytic residues [active]
1116391005554	NAD binding pocket [chemical binding]; other site
1116391005555	phosphate binding motif [ion binding]; other site
1116391005556	beta-alpha-beta structure motif; other site
1116391005557	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005558	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005560	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391005561	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391005562	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1116391005563	dimer interface [polypeptide binding]; other site
1116391005564	active site
1116391005565	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1116391005566	dimer interface [polypeptide binding]; other site
1116391005567	active site
1116391005568	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1116391005569	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391005570	substrate binding site [chemical binding]; other site
1116391005571	ATP binding site [chemical binding]; other site
1116391005572	alpha-mannosidase; Provisional; Region: PRK09819
1116391005573	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1116391005574	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
1116391005575	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1116391005576	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005577	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005579	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391005580	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1116391005581	substrate binding site [chemical binding]; other site
1116391005582	dimer interface [polypeptide binding]; other site
1116391005583	ATP binding site [chemical binding]; other site
1116391005584	PAS fold; Region: PAS_4; pfam08448
1116391005585	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391005586	putative active site [active]
1116391005587	heme pocket [chemical binding]; other site
1116391005588	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391005589	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391005590	metal binding site [ion binding]; metal-binding site
1116391005591	active site
1116391005592	I-site; other site
1116391005593	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1116391005594	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391005595	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391005596	metal binding site [ion binding]; metal-binding site
1116391005597	active site
1116391005598	I-site; other site
1116391005599	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391005600	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391005601	non-specific DNA binding site [nucleotide binding]; other site
1116391005602	salt bridge; other site
1116391005603	sequence-specific DNA binding site [nucleotide binding]; other site
1116391005604	Cupin domain; Region: Cupin_2; pfam07883
1116391005605	Cupin domain; Region: Cupin_2; pfam07883
1116391005606	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391005607	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391005608	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391005609	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1116391005610	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1116391005611	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005612	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005613	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005614	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005615	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1116391005616	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005617	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005619	dimer interface [polypeptide binding]; other site
1116391005620	conserved gate region; other site
1116391005621	putative PBP binding loops; other site
1116391005622	ABC-ATPase subunit interface; other site
1116391005623	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005624	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005625	dimer interface [polypeptide binding]; other site
1116391005626	conserved gate region; other site
1116391005627	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1116391005628	ABC-ATPase subunit interface; other site
1116391005629	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005630	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005631	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005632	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005633	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005634	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005635	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1116391005636	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
1116391005637	iron-sulfur cluster [ion binding]; other site
1116391005638	[2Fe-2S] cluster binding site [ion binding]; other site
1116391005639	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391005640	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
1116391005641	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005642	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005643	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005644	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005645	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005646	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005648	dimer interface [polypeptide binding]; other site
1116391005649	conserved gate region; other site
1116391005650	ABC-ATPase subunit interface; other site
1116391005651	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005653	dimer interface [polypeptide binding]; other site
1116391005654	conserved gate region; other site
1116391005655	ABC-ATPase subunit interface; other site
1116391005656	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005657	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391005658	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1116391005659	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391005660	Spore germination protein; Region: Spore_permease; cl17796
1116391005661	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391005662	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391005663	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391005664	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391005665	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1116391005666	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1116391005667	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1116391005668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391005669	Walker A/P-loop; other site
1116391005670	ATP binding site [chemical binding]; other site
1116391005671	Q-loop/lid; other site
1116391005672	ABC transporter signature motif; other site
1116391005673	Walker B; other site
1116391005674	D-loop; other site
1116391005675	H-loop/switch region; other site
1116391005676	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1116391005677	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1116391005678	HAMP domain; Region: HAMP; pfam00672
1116391005679	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391005680	dimer interface [polypeptide binding]; other site
1116391005681	phosphorylation site [posttranslational modification]
1116391005682	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391005683	ATP binding site [chemical binding]; other site
1116391005684	Mg2+ binding site [ion binding]; other site
1116391005685	G-X-G motif; other site
1116391005686	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391005687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391005688	active site
1116391005689	phosphorylation site [posttranslational modification]
1116391005690	intermolecular recognition site; other site
1116391005691	dimerization interface [polypeptide binding]; other site
1116391005692	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391005693	DNA binding site [nucleotide binding]
1116391005694	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1116391005695	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1116391005696	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1116391005697	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391005698	HEAT repeats; Region: HEAT_2; pfam13646
1116391005699	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005700	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005701	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005702	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
1116391005703	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1116391005704	putative ligand binding site [chemical binding]; other site
1116391005705	putative NAD binding site [chemical binding]; other site
1116391005706	catalytic site [active]
1116391005707	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1116391005708	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1116391005709	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1116391005710	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1116391005711	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1116391005712	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1116391005713	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005714	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391005715	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
1116391005716	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391005717	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005718	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005719	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005720	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391005721	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391005722	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391005723	dimerization interface [polypeptide binding]; other site
1116391005724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391005725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391005726	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391005727	dimerization interface [polypeptide binding]; other site
1116391005728	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391005729	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391005730	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391005731	dimerization interface [polypeptide binding]; other site
1116391005732	Histidine kinase; Region: His_kinase; pfam06580
1116391005733	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391005734	ATP binding site [chemical binding]; other site
1116391005735	Mg2+ binding site [ion binding]; other site
1116391005736	G-X-G motif; other site
1116391005737	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391005738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391005739	active site
1116391005740	phosphorylation site [posttranslational modification]
1116391005741	intermolecular recognition site; other site
1116391005742	dimerization interface [polypeptide binding]; other site
1116391005743	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391005744	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391005746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391005747	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1116391005748	dimerization interface [polypeptide binding]; other site
1116391005749	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391005750	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1116391005751	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391005752	active site
1116391005753	metal binding site [ion binding]; metal-binding site
1116391005754	PKD domain; Region: PKD; pfam00801
1116391005755	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391005756	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391005757	dimerization interface [polypeptide binding]; other site
1116391005758	Histidine kinase; Region: His_kinase; pfam06580
1116391005759	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1116391005760	Mg2+ binding site [ion binding]; other site
1116391005761	G-X-G motif; other site
1116391005762	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391005763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391005764	active site
1116391005765	phosphorylation site [posttranslational modification]
1116391005766	intermolecular recognition site; other site
1116391005767	dimerization interface [polypeptide binding]; other site
1116391005768	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391005769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005770	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005771	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391005772	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005773	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391005774	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005775	dimer interface [polypeptide binding]; other site
1116391005776	ABC-ATPase subunit interface; other site
1116391005777	putative PBP binding loops; other site
1116391005778	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391005779	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005780	dimer interface [polypeptide binding]; other site
1116391005781	conserved gate region; other site
1116391005782	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391005783	ABC-ATPase subunit interface; other site
1116391005784	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1116391005785	active site
1116391005786	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391005787	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1116391005788	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1116391005789	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1116391005790	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1116391005791	active site
1116391005792	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391005793	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391005794	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1116391005795	active site
1116391005796	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391005797	Interdomain contacts; other site
1116391005798	Cytokine receptor motif; other site
1116391005799	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391005800	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391005801	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391005802	Interdomain contacts; other site
1116391005803	Cytokine receptor motif; other site
1116391005804	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391005805	dockerin binding interface; other site
1116391005806	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1116391005807	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391005808	DNA binding residues [nucleotide binding]
1116391005809	putative dimer interface [polypeptide binding]; other site
1116391005810	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900
1116391005811	putative hydrophobic ligand binding site [chemical binding]; other site
1116391005812	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
1116391005813	putative hydrophobic ligand binding site [chemical binding]; other site
1116391005814	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1116391005815	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391005816	NAD(P) binding site [chemical binding]; other site
1116391005817	active site
1116391005818	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1116391005819	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391005820	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391005821	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1116391005822	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391005823	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1116391005824	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391005825	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391005826	Transposase; Region: HTH_Tnp_1; cl17663
1116391005827	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391005828	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391005829	HTH-like domain; Region: HTH_21; pfam13276
1116391005830	Integrase core domain; Region: rve; pfam00665
1116391005831	Integrase core domain; Region: rve_2; pfam13333
1116391005832	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391005833	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391005834	LytTr DNA-binding domain; Region: LytTR; smart00850
1116391005835	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1116391005836	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1116391005837	Transcription antiterminator [Transcription]; Region: NusG; COG0250
1116391005838	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
1116391005839	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1116391005840	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1116391005841	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1116391005842	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
1116391005843	FMN binding site [chemical binding]; other site
1116391005844	substrate binding site [chemical binding]; other site
1116391005845	putative catalytic residue [active]
1116391005846	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1116391005847	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1116391005848	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005849	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391005850	active site
1116391005851	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1116391005852	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1116391005853	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1116391005854	putative NADP binding site [chemical binding]; other site
1116391005855	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1116391005856	active site
1116391005857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391005858	S-adenosylmethionine binding site [chemical binding]; other site
1116391005859	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1116391005860	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391005861	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005862	active site
1116391005863	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1116391005864	KR domain; Region: KR; pfam08659
1116391005865	putative NADP binding site [chemical binding]; other site
1116391005866	active site
1116391005867	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391005868	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005869	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391005870	active site
1116391005871	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391005872	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005873	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391005874	active site
1116391005875	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1116391005876	putative NADP binding site [chemical binding]; other site
1116391005877	KR domain; Region: KR; pfam08659
1116391005878	active site
1116391005879	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391005880	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005881	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391005882	active site
1116391005883	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391005884	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005885	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1116391005886	active site
1116391005887	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1116391005888	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1116391005889	putative NADP binding site [chemical binding]; other site
1116391005890	KR domain; Region: KR; pfam08659
1116391005891	active site
1116391005892	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1116391005893	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391005894	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391005895	active site
1116391005896	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391005897	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1116391005898	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1116391005899	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1116391005900	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1116391005901	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
1116391005902	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
1116391005903	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1116391005904	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1116391005905	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391005906	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391005907	DNA binding site [nucleotide binding]
1116391005908	domain linker motif; other site
1116391005909	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1116391005910	dimerization interface [polypeptide binding]; other site
1116391005911	ligand binding site [chemical binding]; other site
1116391005912	sodium binding site [ion binding]; other site
1116391005913	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391005914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005915	dimer interface [polypeptide binding]; other site
1116391005916	conserved gate region; other site
1116391005917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391005918	ABC-ATPase subunit interface; other site
1116391005919	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391005920	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1116391005921	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391005922	substrate binding [chemical binding]; other site
1116391005923	active site
1116391005924	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391005925	Phosphotransferase enzyme family; Region: APH; pfam01636
1116391005926	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391005927	active site
1116391005928	ATP binding site [chemical binding]; other site
1116391005929	substrate binding site [chemical binding]; other site
1116391005930	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1116391005931	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1116391005932	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391005933	substrate binding [chemical binding]; other site
1116391005934	active site
1116391005935	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391005936	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1116391005937	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1116391005938	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391005939	putative substrate translocation pore; other site
1116391005940	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1116391005941	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391005942	inhibitor-cofactor binding pocket; inhibition site
1116391005943	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391005944	catalytic residue [active]
1116391005945	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1116391005946	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391005947	NAD(P) binding site [chemical binding]; other site
1116391005948	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1116391005949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391005950	motif II; other site
1116391005951	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1116391005952	active site
1116391005953	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1116391005954	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1116391005955	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1116391005956	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1116391005957	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391005958	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1116391005959	substrate binding site [chemical binding]; other site
1116391005960	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391005961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005962	dimer interface [polypeptide binding]; other site
1116391005963	conserved gate region; other site
1116391005964	putative PBP binding loops; other site
1116391005965	ABC-ATPase subunit interface; other site
1116391005966	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1116391005967	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1116391005968	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391005969	dimer interface [polypeptide binding]; other site
1116391005970	conserved gate region; other site
1116391005971	putative PBP binding loops; other site
1116391005972	ABC-ATPase subunit interface; other site
1116391005973	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391005974	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1116391005975	Walker A/P-loop; other site
1116391005976	ATP binding site [chemical binding]; other site
1116391005977	Q-loop/lid; other site
1116391005978	ABC transporter signature motif; other site
1116391005979	Walker B; other site
1116391005980	D-loop; other site
1116391005981	H-loop/switch region; other site
1116391005982	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1116391005983	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391005984	Walker A/P-loop; other site
1116391005985	ATP binding site [chemical binding]; other site
1116391005986	Q-loop/lid; other site
1116391005987	ABC transporter signature motif; other site
1116391005988	Walker B; other site
1116391005989	D-loop; other site
1116391005990	H-loop/switch region; other site
1116391005991	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391005992	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391005993	putative substrate translocation pore; other site
1116391005994	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391005995	dimerization interface [polypeptide binding]; other site
1116391005996	putative DNA binding site [nucleotide binding]; other site
1116391005997	putative Zn2+ binding site [ion binding]; other site
1116391005998	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1116391005999	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1116391006000	metal-binding site [ion binding]
1116391006001	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1116391006002	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1116391006003	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1116391006004	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391006005	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1116391006006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391006007	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1116391006008	dimerization interface [polypeptide binding]; other site
1116391006009	substrate binding pocket [chemical binding]; other site
1116391006010	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1116391006011	putative deacylase active site [active]
1116391006012	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391006013	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391006014	Transposase; Region: HTH_Tnp_1; cl17663
1116391006015	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391006016	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391006017	HTH-like domain; Region: HTH_21; pfam13276
1116391006018	Integrase core domain; Region: rve; pfam00665
1116391006019	Integrase core domain; Region: rve_2; pfam13333
1116391006020	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1116391006021	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391006022	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1116391006023	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391006024	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1116391006025	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006026	Interdomain contacts; other site
1116391006027	Cytokine receptor motif; other site
1116391006028	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006029	Interdomain contacts; other site
1116391006030	Cytokine receptor motif; other site
1116391006031	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006032	Interdomain contacts; other site
1116391006033	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006034	Interdomain contacts; other site
1116391006035	Cytokine receptor motif; other site
1116391006036	putative pectinesterase; Region: PLN02432; cl01911
1116391006037	Pectinesterase; Region: Pectinesterase; pfam01095
1116391006038	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006039	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006040	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006042	dimer interface [polypeptide binding]; other site
1116391006043	conserved gate region; other site
1116391006044	ABC-ATPase subunit interface; other site
1116391006045	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006047	dimer interface [polypeptide binding]; other site
1116391006048	conserved gate region; other site
1116391006049	putative PBP binding loops; other site
1116391006050	ABC-ATPase subunit interface; other site
1116391006051	Predicted transcriptional regulators [Transcription]; Region: COG1378
1116391006052	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1116391006053	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1116391006054	C-terminal domain interface [polypeptide binding]; other site
1116391006055	sugar binding site [chemical binding]; other site
1116391006056	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1116391006057	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1116391006058	YxiJ-like protein; Region: YxiJ; pfam14176
1116391006059	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1116391006060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391006061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391006062	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1116391006063	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391006064	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1116391006065	NADP binding site [chemical binding]; other site
1116391006066	substrate binding site [chemical binding]; other site
1116391006067	active site
1116391006068	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1116391006069	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1116391006070	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
1116391006071	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1116391006072	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1116391006073	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391006074	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006075	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1116391006076	classical (c) SDRs; Region: SDR_c; cd05233
1116391006077	NAD(P) binding site [chemical binding]; other site
1116391006078	active site
1116391006079	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391006080	Walker A/P-loop; other site
1116391006081	ATP binding site [chemical binding]; other site
1116391006082	Q-loop/lid; other site
1116391006083	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1116391006084	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1116391006085	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391006086	Walker A/P-loop; other site
1116391006087	ATP binding site [chemical binding]; other site
1116391006088	Q-loop/lid; other site
1116391006089	ABC transporter signature motif; other site
1116391006090	Walker B; other site
1116391006091	D-loop; other site
1116391006092	H-loop/switch region; other site
1116391006093	DinB family; Region: DinB; cl17821
1116391006094	DinB superfamily; Region: DinB_2; pfam12867
1116391006095	Putative esterase; Region: Esterase; pfam00756
1116391006096	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1116391006097	Cupin domain; Region: Cupin_2; cl17218
1116391006098	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391006099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006100	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1116391006101	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391006102	intersubunit interface [polypeptide binding]; other site
1116391006103	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1116391006104	putative FMN binding site [chemical binding]; other site
1116391006105	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1116391006106	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391006107	ABC-ATPase subunit  interface; other site
1116391006108	dimer interface [polypeptide binding]; other site
1116391006109	putative PBP binding regions; other site
1116391006110	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391006111	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391006112	ABC-ATPase subunit  interface; other site
1116391006113	dimer interface [polypeptide binding]; other site
1116391006114	putative PBP binding regions; other site
1116391006115	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1116391006116	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391006117	siderophore binding site; other site
1116391006118	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391006119	Sugar (and other) transporter; Region: Sugar_tr; pfam00083
1116391006120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391006121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391006122	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391006123	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391006124	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391006125	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391006126	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391006127	Metal-binding active site; metal-binding site
1116391006128	transketolase; Reviewed; Region: PRK05899
1116391006129	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1116391006130	TPP-binding site [chemical binding]; other site
1116391006131	dimer interface [polypeptide binding]; other site
1116391006132	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1116391006133	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1116391006134	PYR/PP interface [polypeptide binding]; other site
1116391006135	dimer interface [polypeptide binding]; other site
1116391006136	TPP binding site [chemical binding]; other site
1116391006137	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391006138	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1116391006139	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1116391006140	NAD(P) binding site [chemical binding]; other site
1116391006141	catalytic residues [active]
1116391006142	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1116391006143	tartrate dehydrogenase; Provisional; Region: PRK08194
1116391006144	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1116391006145	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1116391006146	tetrameric interface [polypeptide binding]; other site
1116391006147	NAD binding site [chemical binding]; other site
1116391006148	catalytic residues [active]
1116391006149	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1116391006150	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391006151	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1116391006152	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391006153	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1116391006154	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391006155	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1116391006156	substrate binding site [chemical binding]; other site
1116391006157	ATP binding site [chemical binding]; other site
1116391006158	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1116391006159	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1116391006160	PYR/PP interface [polypeptide binding]; other site
1116391006161	dimer interface [polypeptide binding]; other site
1116391006162	TPP binding site [chemical binding]; other site
1116391006163	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391006164	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1116391006165	TPP-binding site; other site
1116391006166	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391006167	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391006168	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1116391006169	intersubunit interface [polypeptide binding]; other site
1116391006170	active site
1116391006171	zinc binding site [ion binding]; other site
1116391006172	Na+ binding site [ion binding]; other site
1116391006173	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391006174	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1116391006175	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391006176	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1116391006177	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1116391006178	active site
1116391006179	dimerization interface [polypeptide binding]; other site
1116391006180	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391006181	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1116391006182	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391006183	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006184	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1116391006185	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1116391006186	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1116391006187	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1116391006188	S-layer homology domain; Region: SLH; pfam00395
1116391006189	S-layer homology domain; Region: SLH; pfam00395
1116391006190	S-layer homology domain; Region: SLH; pfam00395
1116391006191	Cobalt transport protein; Region: CbiQ; cl00463
1116391006192	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1116391006193	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1116391006194	Walker A/P-loop; other site
1116391006195	ATP binding site [chemical binding]; other site
1116391006196	Q-loop/lid; other site
1116391006197	ABC transporter signature motif; other site
1116391006198	Walker B; other site
1116391006199	D-loop; other site
1116391006200	H-loop/switch region; other site
1116391006201	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1116391006202	Walker A/P-loop; other site
1116391006203	ATP binding site [chemical binding]; other site
1116391006204	Q-loop/lid; other site
1116391006205	ABC transporter signature motif; other site
1116391006206	Walker B; other site
1116391006207	D-loop; other site
1116391006208	H-loop/switch region; other site
1116391006209	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1116391006210	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1116391006211	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391006212	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391006213	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391006214	dimerization interface [polypeptide binding]; other site
1116391006215	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1116391006216	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1116391006217	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1116391006218	DinB superfamily; Region: DinB_2; pfam12867
1116391006219	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391006220	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391006221	Coenzyme A binding pocket [chemical binding]; other site
1116391006222	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391006223	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1116391006224	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1116391006225	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391006226	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391006227	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391006228	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391006229	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391006230	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391006231	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391006232	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391006233	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
1116391006234	NmrA-like family; Region: NmrA; pfam05368
1116391006235	NADP binding site [chemical binding]; other site
1116391006236	active site
1116391006237	regulatory binding site [polypeptide binding]; other site
1116391006238	hypothetical protein; Validated; Region: PRK06186
1116391006239	conserved cys residue [active]
1116391006240	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1116391006241	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006242	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006243	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1116391006244	Histidine kinase; Region: His_kinase; pfam06580
1116391006245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006246	ATP binding site [chemical binding]; other site
1116391006247	Mg2+ binding site [ion binding]; other site
1116391006248	G-X-G motif; other site
1116391006249	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391006250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006251	active site
1116391006252	phosphorylation site [posttranslational modification]
1116391006253	intermolecular recognition site; other site
1116391006254	dimerization interface [polypeptide binding]; other site
1116391006255	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391006256	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006257	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006258	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1116391006259	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391006260	substrate binding [chemical binding]; other site
1116391006261	active site
1116391006262	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391006263	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006265	putative PBP binding loops; other site
1116391006266	ABC-ATPase subunit interface; other site
1116391006267	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006268	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006269	dimer interface [polypeptide binding]; other site
1116391006270	conserved gate region; other site
1116391006271	putative PBP binding loops; other site
1116391006272	ABC-ATPase subunit interface; other site
1116391006273	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1116391006274	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391006275	substrate binding [chemical binding]; other site
1116391006276	active site
1116391006277	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391006278	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
1116391006279	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1116391006280	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391006281	substrate binding [chemical binding]; other site
1116391006282	active site
1116391006283	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391006284	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391006285	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391006286	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1116391006287	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1116391006288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391006289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391006290	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1116391006291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391006292	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391006293	putative substrate translocation pore; other site
1116391006294	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391006295	BclB C-terminal domain; Region: exospore_TM; TIGR03721
1116391006296	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006298	dimer interface [polypeptide binding]; other site
1116391006299	conserved gate region; other site
1116391006300	ABC-ATPase subunit interface; other site
1116391006301	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006303	dimer interface [polypeptide binding]; other site
1116391006304	conserved gate region; other site
1116391006305	putative PBP binding loops; other site
1116391006306	ABC-ATPase subunit interface; other site
1116391006307	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006308	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006309	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006310	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006311	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391006312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391006313	Predicted membrane protein [Function unknown]; Region: COG4270
1116391006314	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391006315	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1116391006316	putative NAD(P) binding site [chemical binding]; other site
1116391006317	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391006318	active site
1116391006319	catalytic triad [active]
1116391006320	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391006321	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1116391006322	putative active cleft [active]
1116391006323	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006324	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006325	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006327	dimer interface [polypeptide binding]; other site
1116391006328	conserved gate region; other site
1116391006329	ABC-ATPase subunit interface; other site
1116391006330	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006332	dimer interface [polypeptide binding]; other site
1116391006333	conserved gate region; other site
1116391006334	putative PBP binding loops; other site
1116391006335	ABC-ATPase subunit interface; other site
1116391006336	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006337	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391006338	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391006339	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391006340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006341	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391006342	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391006343	metal binding site [ion binding]; metal-binding site
1116391006344	active site
1116391006345	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006346	Interdomain contacts; other site
1116391006347	Cytokine receptor motif; other site
1116391006348	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1116391006349	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
1116391006350	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1116391006351	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1116391006352	putative ligand binding site [chemical binding]; other site
1116391006353	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391006354	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391006355	Walker A/P-loop; other site
1116391006356	ATP binding site [chemical binding]; other site
1116391006357	Q-loop/lid; other site
1116391006358	ABC transporter signature motif; other site
1116391006359	Walker B; other site
1116391006360	D-loop; other site
1116391006361	H-loop/switch region; other site
1116391006362	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391006363	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391006364	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391006365	TM-ABC transporter signature motif; other site
1116391006366	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391006367	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391006368	DNA binding site [nucleotide binding]
1116391006369	domain linker motif; other site
1116391006370	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391006371	dimerization interface [polypeptide binding]; other site
1116391006372	ligand binding site [chemical binding]; other site
1116391006373	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391006374	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391006375	DNA binding site [nucleotide binding]
1116391006376	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1116391006377	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006379	ABC-ATPase subunit interface; other site
1116391006380	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006382	dimer interface [polypeptide binding]; other site
1116391006383	conserved gate region; other site
1116391006384	putative PBP binding loops; other site
1116391006385	ABC-ATPase subunit interface; other site
1116391006386	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006387	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006388	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1116391006389	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1116391006390	substrate binding [chemical binding]; other site
1116391006391	active site
1116391006392	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1116391006393	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1116391006394	Isochorismatase family; Region: Isochorismatase; pfam00857
1116391006395	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1116391006396	catalytic triad [active]
1116391006397	dimer interface [polypeptide binding]; other site
1116391006398	conserved cis-peptide bond; other site
1116391006399	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
1116391006400	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1116391006401	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1116391006402	active site
1116391006403	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
1116391006404	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391006405	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391006406	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391006407	putative substrate translocation pore; other site
1116391006408	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1116391006409	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1116391006410	dimerization interface [polypeptide binding]; other site
1116391006411	DPS ferroxidase diiron center [ion binding]; other site
1116391006412	ion pore; other site
1116391006413	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1116391006414	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1116391006415	substrate binding pocket [chemical binding]; other site
1116391006416	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391006417	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1116391006418	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391006419	Zn binding site [ion binding]; other site
1116391006420	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1116391006421	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391006422	Zn binding site [ion binding]; other site
1116391006423	Predicted esterase [General function prediction only]; Region: COG0400
1116391006424	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1116391006425	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1116391006426	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1116391006427	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1116391006428	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391006429	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391006430	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006431	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006432	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1116391006433	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
1116391006434	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1116391006435	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1116391006436	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1116391006437	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1116391006438	putative DNA binding site [nucleotide binding]; other site
1116391006439	putative Zn2+ binding site [ion binding]; other site
1116391006440	AsnC family; Region: AsnC_trans_reg; pfam01037
1116391006441	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391006442	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391006443	dimerization interface [polypeptide binding]; other site
1116391006444	putative DNA binding site [nucleotide binding]; other site
1116391006445	putative Zn2+ binding site [ion binding]; other site
1116391006446	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391006447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391006448	putative substrate translocation pore; other site
1116391006449	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006451	dimer interface [polypeptide binding]; other site
1116391006452	conserved gate region; other site
1116391006453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391006454	ABC-ATPase subunit interface; other site
1116391006455	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006457	dimer interface [polypeptide binding]; other site
1116391006458	conserved gate region; other site
1116391006459	putative PBP binding loops; other site
1116391006460	ABC-ATPase subunit interface; other site
1116391006461	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006462	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006463	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391006464	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006465	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391006466	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391006467	ABC-ATPase subunit  interface; other site
1116391006468	dimer interface [polypeptide binding]; other site
1116391006469	putative PBP binding regions; other site
1116391006470	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1116391006471	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391006472	ABC-ATPase subunit  interface; other site
1116391006473	dimer interface [polypeptide binding]; other site
1116391006474	putative PBP binding regions; other site
1116391006475	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1116391006476	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391006477	intersubunit interface [polypeptide binding]; other site
1116391006478	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1116391006479	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1116391006480	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391006481	metal binding site [ion binding]; metal-binding site
1116391006482	active site
1116391006483	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006484	Interdomain contacts; other site
1116391006485	Cytokine receptor motif; other site
1116391006486	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006487	Interdomain contacts; other site
1116391006488	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391006489	dockerin binding interface; other site
1116391006490	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391006491	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1116391006492	inhibitor binding site; inhibition site
1116391006493	catalytic Zn binding site [ion binding]; other site
1116391006494	structural Zn binding site [ion binding]; other site
1116391006495	NADP binding site [chemical binding]; other site
1116391006496	tetramer interface [polypeptide binding]; other site
1116391006497	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1116391006498	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1116391006499	AAA ATPase domain; Region: AAA_16; pfam13191
1116391006500	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1116391006501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391006502	TPR motif; other site
1116391006503	binding surface
1116391006504	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1116391006505	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391006506	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391006507	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391006508	Spore germination protein; Region: Spore_permease; cl17796
1116391006509	Spore germination protein; Region: Spore_permease; cl17796
1116391006510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391006511	non-specific DNA binding site [nucleotide binding]; other site
1116391006512	salt bridge; other site
1116391006513	sequence-specific DNA binding site [nucleotide binding]; other site
1116391006514	SET domain; Region: SET; pfam00856
1116391006515	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
1116391006516	putative hydrophobic ligand binding site [chemical binding]; other site
1116391006517	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006518	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006519	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006520	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006521	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391006523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006524	dimer interface [polypeptide binding]; other site
1116391006525	ABC-ATPase subunit interface; other site
1116391006526	putative PBP binding loops; other site
1116391006527	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006529	dimer interface [polypeptide binding]; other site
1116391006530	conserved gate region; other site
1116391006531	ABC-ATPase subunit interface; other site
1116391006532	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391006533	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391006534	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391006535	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
1116391006536	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1116391006537	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391006538	DNA-binding site [nucleotide binding]; DNA binding site
1116391006539	FCD domain; Region: FCD; pfam07729
1116391006540	mannonate dehydratase; Provisional; Region: PRK03906
1116391006541	mannonate dehydratase; Region: uxuA; TIGR00695
1116391006542	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1116391006543	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
1116391006544	putative NAD(P) binding site [chemical binding]; other site
1116391006545	active site
1116391006546	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1116391006547	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1116391006548	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391006549	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006550	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391006551	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006552	Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512
1116391006553	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
1116391006554	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
1116391006555	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
1116391006556	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006558	dimer interface [polypeptide binding]; other site
1116391006559	putative PBP binding loops; other site
1116391006560	ABC-ATPase subunit interface; other site
1116391006561	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006563	dimer interface [polypeptide binding]; other site
1116391006564	conserved gate region; other site
1116391006565	putative PBP binding loops; other site
1116391006566	ABC-ATPase subunit interface; other site
1116391006567	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391006568	Histidine kinase; Region: His_kinase; pfam06580
1116391006569	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1116391006570	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006571	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006572	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391006573	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006574	active site
1116391006575	phosphorylation site [posttranslational modification]
1116391006576	intermolecular recognition site; other site
1116391006577	dimerization interface [polypeptide binding]; other site
1116391006578	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006581	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391006582	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1116391006583	inhibitor binding site; inhibition site
1116391006584	catalytic Zn binding site [ion binding]; other site
1116391006585	structural Zn binding site [ion binding]; other site
1116391006586	NADP binding site [chemical binding]; other site
1116391006587	tetramer interface [polypeptide binding]; other site
1116391006588	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1116391006589	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
1116391006590	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1116391006591	active site
1116391006592	DNA binding site [nucleotide binding]
1116391006593	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1116391006594	Benzoate membrane transport protein; Region: BenE; pfam03594
1116391006595	benzoate transporter; Region: benE; TIGR00843
1116391006596	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1116391006597	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1116391006598	NAD binding site [chemical binding]; other site
1116391006599	substrate binding site [chemical binding]; other site
1116391006600	putative active site [active]
1116391006601	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1116391006602	UbiA prenyltransferase family; Region: UbiA; pfam01040
1116391006603	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391006604	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391006605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006606	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1116391006607	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1116391006608	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1116391006609	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1116391006610	NAD(P) binding site [chemical binding]; other site
1116391006611	catalytic residues [active]
1116391006612	putative dehydratase; Provisional; Region: PRK08211
1116391006613	Dehydratase family; Region: ILVD_EDD; cl00340
1116391006614	malate:quinone oxidoreductase; Validated; Region: PRK05257
1116391006615	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1116391006616	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391006617	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391006618	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391006619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006620	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1116391006621	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
1116391006622	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391006623	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1116391006624	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1116391006625	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006626	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006627	Cupin domain; Region: Cupin_2; pfam07883
1116391006628	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006630	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391006631	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391006632	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1116391006633	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1116391006634	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1116391006635	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391006636	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391006637	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1116391006638	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1116391006639	dimerization domain swap beta strand [polypeptide binding]; other site
1116391006640	regulatory protein interface [polypeptide binding]; other site
1116391006641	active site
1116391006642	regulatory phosphorylation site [posttranslational modification]; other site
1116391006643	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1116391006644	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1116391006645	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1116391006646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006647	dimer interface [polypeptide binding]; other site
1116391006648	conserved gate region; other site
1116391006649	ABC-ATPase subunit interface; other site
1116391006650	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006652	dimer interface [polypeptide binding]; other site
1116391006653	conserved gate region; other site
1116391006654	ABC-ATPase subunit interface; other site
1116391006655	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391006656	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391006657	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006658	S-layer homology domain; Region: SLH; pfam00395
1116391006659	S-layer homology domain; Region: SLH; pfam00395
1116391006660	S-layer homology domain; Region: SLH; pfam00395
1116391006661	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1116391006662	Carbohydrate binding module 27; Region: CBM27; pfam09212
1116391006663	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391006664	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391006665	dimerization interface [polypeptide binding]; other site
1116391006666	Histidine kinase; Region: His_kinase; pfam06580
1116391006667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006668	ATP binding site [chemical binding]; other site
1116391006669	Mg2+ binding site [ion binding]; other site
1116391006670	G-X-G motif; other site
1116391006671	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391006672	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006673	active site
1116391006674	phosphorylation site [posttranslational modification]
1116391006675	intermolecular recognition site; other site
1116391006676	dimerization interface [polypeptide binding]; other site
1116391006677	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006678	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006679	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006680	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1116391006681	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391006682	active site
1116391006683	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1116391006684	dimerization interface [polypeptide binding]; other site
1116391006685	putative active cleft [active]
1116391006686	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
1116391006687	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1116391006688	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391006689	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391006690	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391006691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006692	active site
1116391006693	phosphorylation site [posttranslational modification]
1116391006694	intermolecular recognition site; other site
1116391006695	dimerization interface [polypeptide binding]; other site
1116391006696	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391006697	DNA binding site [nucleotide binding]
1116391006698	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
1116391006699	Carbohydrate binding domain; Region: CBM_25; smart01066
1116391006700	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006701	Interdomain contacts; other site
1116391006702	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1116391006703	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1116391006704	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1116391006705	active site
1116391006706	catalytic site [active]
1116391006707	CHASE3 domain; Region: CHASE3; cl05000
1116391006708	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391006709	dimerization interface [polypeptide binding]; other site
1116391006710	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391006711	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391006712	metal binding site [ion binding]; metal-binding site
1116391006713	active site
1116391006714	I-site; other site
1116391006715	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006716	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006717	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1116391006718	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391006719	active site
1116391006720	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006721	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391006722	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391006723	dimerization interface [polypeptide binding]; other site
1116391006724	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391006725	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391006726	dimer interface [polypeptide binding]; other site
1116391006727	putative CheW interface [polypeptide binding]; other site
1116391006728	Histidine kinase; Region: His_kinase; pfam06580
1116391006729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006730	ATP binding site [chemical binding]; other site
1116391006731	Mg2+ binding site [ion binding]; other site
1116391006732	G-X-G motif; other site
1116391006733	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391006734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006735	active site
1116391006736	phosphorylation site [posttranslational modification]
1116391006737	intermolecular recognition site; other site
1116391006738	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006740	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006741	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1116391006742	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1116391006743	Ca binding site [ion binding]; other site
1116391006744	active site
1116391006745	catalytic site [active]
1116391006746	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1116391006747	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006748	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391006749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006750	dimer interface [polypeptide binding]; other site
1116391006751	conserved gate region; other site
1116391006752	putative PBP binding loops; other site
1116391006753	ABC-ATPase subunit interface; other site
1116391006754	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006756	dimer interface [polypeptide binding]; other site
1116391006757	conserved gate region; other site
1116391006758	putative PBP binding loops; other site
1116391006759	ABC-ATPase subunit interface; other site
1116391006760	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
1116391006761	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391006762	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391006763	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1116391006764	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391006765	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1116391006766	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1116391006767	putative metal binding site [ion binding]; other site
1116391006768	Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; pfam02752
1116391006769	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
1116391006770	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1116391006771	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391006772	Interdomain contacts; other site
1116391006773	Cytokine receptor motif; other site
1116391006774	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391006775	dockerin binding interface; other site
1116391006776	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391006777	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391006778	dimerization interface [polypeptide binding]; other site
1116391006779	Histidine kinase; Region: His_kinase; pfam06580
1116391006780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006781	ATP binding site [chemical binding]; other site
1116391006782	Mg2+ binding site [ion binding]; other site
1116391006783	G-X-G motif; other site
1116391006784	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391006785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006786	active site
1116391006787	phosphorylation site [posttranslational modification]
1116391006788	intermolecular recognition site; other site
1116391006789	dimerization interface [polypeptide binding]; other site
1116391006790	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006791	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006792	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006793	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391006794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006795	dimer interface [polypeptide binding]; other site
1116391006796	conserved gate region; other site
1116391006797	putative PBP binding loops; other site
1116391006798	ABC-ATPase subunit interface; other site
1116391006799	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006801	dimer interface [polypeptide binding]; other site
1116391006802	conserved gate region; other site
1116391006803	putative PBP binding loops; other site
1116391006804	ABC-ATPase subunit interface; other site
1116391006805	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006806	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006807	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391006808	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391006809	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391006810	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391006811	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391006812	Spore germination protein; Region: Spore_permease; cl17796
1116391006813	DinB family; Region: DinB; cl17821
1116391006814	DinB superfamily; Region: DinB_2; pfam12867
1116391006815	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391006816	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391006817	metal binding site [ion binding]; metal-binding site
1116391006818	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1116391006819	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391006820	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391006821	dimerization interface [polypeptide binding]; other site
1116391006822	Histidine kinase; Region: His_kinase; pfam06580
1116391006823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006824	ATP binding site [chemical binding]; other site
1116391006825	Mg2+ binding site [ion binding]; other site
1116391006826	G-X-G motif; other site
1116391006827	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391006828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006829	active site
1116391006830	phosphorylation site [posttranslational modification]
1116391006831	intermolecular recognition site; other site
1116391006832	dimerization interface [polypeptide binding]; other site
1116391006833	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006834	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006835	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006836	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006837	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006838	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391006839	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391006840	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391006841	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391006842	dimerization interface [polypeptide binding]; other site
1116391006843	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1116391006844	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1116391006845	hinge; other site
1116391006846	active site
1116391006847	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1116391006848	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1116391006849	Tetramer interface [polypeptide binding]; other site
1116391006850	active site
1116391006851	FMN-binding site [chemical binding]; other site
1116391006852	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006854	dimer interface [polypeptide binding]; other site
1116391006855	conserved gate region; other site
1116391006856	putative PBP binding loops; other site
1116391006857	ABC-ATPase subunit interface; other site
1116391006858	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006859	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006860	dimer interface [polypeptide binding]; other site
1116391006861	conserved gate region; other site
1116391006862	putative PBP binding loops; other site
1116391006863	ABC-ATPase subunit interface; other site
1116391006864	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006865	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006866	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391006867	catalytic residues [active]
1116391006868	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1116391006869	metal-binding site [ion binding]
1116391006870	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1116391006871	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391006872	putative substrate translocation pore; other site
1116391006873	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391006874	MarR family; Region: MarR_2; pfam12802
1116391006875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391006876	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1116391006877	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1116391006878	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1116391006879	P-loop, Walker A motif; other site
1116391006880	Base recognition motif; other site
1116391006881	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1116391006882	S-layer homology domain; Region: SLH; pfam00395
1116391006883	amidase; Provisional; Region: PRK06828
1116391006884	Amidase; Region: Amidase; pfam01425
1116391006885	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391006886	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391006887	metal binding site [ion binding]; metal-binding site
1116391006888	active site
1116391006889	I-site; other site
1116391006890	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1116391006891	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1116391006892	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391006893	dockerin binding interface; other site
1116391006894	S-layer homology domain; Region: SLH; pfam00395
1116391006895	S-layer homology domain; Region: SLH; pfam00395
1116391006896	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006897	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006898	dimer interface [polypeptide binding]; other site
1116391006899	conserved gate region; other site
1116391006900	ABC-ATPase subunit interface; other site
1116391006901	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006903	dimer interface [polypeptide binding]; other site
1116391006904	ABC-ATPase subunit interface; other site
1116391006905	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006906	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391006907	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1116391006908	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391006909	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1116391006910	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1116391006911	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391006912	MarR family; Region: MarR; pfam01047
1116391006913	MarR family; Region: MarR_2; cl17246
1116391006914	Pirin; Region: Pirin; pfam02678
1116391006915	Pirin-related protein [General function prediction only]; Region: COG1741
1116391006916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1116391006917	dimerization interface [polypeptide binding]; other site
1116391006918	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391006919	Histidine kinase; Region: His_kinase; pfam06580
1116391006920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006921	ATP binding site [chemical binding]; other site
1116391006922	Mg2+ binding site [ion binding]; other site
1116391006923	G-X-G motif; other site
1116391006924	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391006925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006926	active site
1116391006927	phosphorylation site [posttranslational modification]
1116391006928	intermolecular recognition site; other site
1116391006929	dimerization interface [polypeptide binding]; other site
1116391006930	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391006931	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006932	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1116391006933	SnoaL-like domain; Region: SnoaL_3; pfam13474
1116391006934	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1116391006935	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006936	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006937	dimer interface [polypeptide binding]; other site
1116391006938	conserved gate region; other site
1116391006939	ABC-ATPase subunit interface; other site
1116391006940	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006942	dimer interface [polypeptide binding]; other site
1116391006943	conserved gate region; other site
1116391006944	putative PBP binding loops; other site
1116391006945	ABC-ATPase subunit interface; other site
1116391006946	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391006947	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391006948	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391006949	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391006950	dimerization interface [polypeptide binding]; other site
1116391006951	Histidine kinase; Region: His_kinase; pfam06580
1116391006952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391006953	ATP binding site [chemical binding]; other site
1116391006954	Mg2+ binding site [ion binding]; other site
1116391006955	G-X-G motif; other site
1116391006956	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391006957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391006958	active site
1116391006959	phosphorylation site [posttranslational modification]
1116391006960	intermolecular recognition site; other site
1116391006961	dimerization interface [polypeptide binding]; other site
1116391006962	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006963	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391006964	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1116391006965	catalytic core [active]
1116391006966	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1116391006967	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391006968	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391006969	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1116391006970	catalytic site [active]
1116391006971	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391006972	HTH domain; Region: HTH_11; pfam08279
1116391006973	WYL domain; Region: WYL; pfam13280
1116391006974	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
1116391006975	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1116391006976	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1116391006977	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1116391006978	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1116391006979	active site
1116391006980	putative catalytic site [active]
1116391006981	DNA binding site [nucleotide binding]
1116391006982	putative phosphate binding site [ion binding]; other site
1116391006983	metal binding site A [ion binding]; metal-binding site
1116391006984	AP binding site [nucleotide binding]; other site
1116391006985	metal binding site B [ion binding]; metal-binding site
1116391006986	PilZ domain; Region: PilZ; pfam07238
1116391006987	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391006988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006989	dimer interface [polypeptide binding]; other site
1116391006990	conserved gate region; other site
1116391006991	ABC-ATPase subunit interface; other site
1116391006992	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391006993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391006994	dimer interface [polypeptide binding]; other site
1116391006995	conserved gate region; other site
1116391006996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391006997	ABC-ATPase subunit interface; other site
1116391006998	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391006999	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007000	dimerization interface [polypeptide binding]; other site
1116391007001	Histidine kinase; Region: His_kinase; pfam06580
1116391007002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007003	ATP binding site [chemical binding]; other site
1116391007004	Mg2+ binding site [ion binding]; other site
1116391007005	G-X-G motif; other site
1116391007006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007007	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391007008	active site
1116391007009	phosphorylation site [posttranslational modification]
1116391007010	intermolecular recognition site; other site
1116391007011	dimerization interface [polypeptide binding]; other site
1116391007012	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007013	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007014	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007015	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007016	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007017	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391007018	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1116391007019	NAD(P) binding site [chemical binding]; other site
1116391007020	active site
1116391007021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1116391007022	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1116391007023	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007024	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391007025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007026	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007027	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007028	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391007029	dimer interface [polypeptide binding]; other site
1116391007030	phosphorylation site [posttranslational modification]
1116391007031	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007032	ATP binding site [chemical binding]; other site
1116391007033	Mg2+ binding site [ion binding]; other site
1116391007034	G-X-G motif; other site
1116391007035	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1116391007036	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391007037	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391007038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391007039	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391007040	putative substrate translocation pore; other site
1116391007041	Predicted transcriptional regulators [Transcription]; Region: COG1510
1116391007042	MarR family; Region: MarR_2; cl17246
1116391007043	BCCT family transporter; Region: BCCT; pfam02028
1116391007044	MULE transposase domain; Region: MULE; pfam10551
1116391007045	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1116391007046	Predicted transcriptional regulator [Transcription]; Region: COG4189
1116391007047	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391007048	dimerization interface [polypeptide binding]; other site
1116391007049	putative DNA binding site [nucleotide binding]; other site
1116391007050	putative Zn2+ binding site [ion binding]; other site
1116391007051	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391007052	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391007053	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391007054	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007055	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007056	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391007057	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007058	dimerization interface [polypeptide binding]; other site
1116391007059	Histidine kinase; Region: His_kinase; pfam06580
1116391007060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007061	ATP binding site [chemical binding]; other site
1116391007062	Mg2+ binding site [ion binding]; other site
1116391007063	G-X-G motif; other site
1116391007064	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391007065	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007066	active site
1116391007067	phosphorylation site [posttranslational modification]
1116391007068	intermolecular recognition site; other site
1116391007069	dimerization interface [polypeptide binding]; other site
1116391007070	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1116391007071	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391007072	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007073	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007074	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007075	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007076	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007077	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391007078	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007079	dimer interface [polypeptide binding]; other site
1116391007080	conserved gate region; other site
1116391007081	ABC-ATPase subunit interface; other site
1116391007082	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007084	dimer interface [polypeptide binding]; other site
1116391007085	conserved gate region; other site
1116391007086	putative PBP binding loops; other site
1116391007087	ABC-ATPase subunit interface; other site
1116391007088	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007089	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007090	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1116391007091	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391007092	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1116391007093	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1116391007094	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007095	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391007096	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007097	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007098	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007099	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007100	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391007101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007102	putative PBP binding loops; other site
1116391007103	ABC-ATPase subunit interface; other site
1116391007104	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007106	dimer interface [polypeptide binding]; other site
1116391007107	conserved gate region; other site
1116391007108	putative PBP binding loops; other site
1116391007109	ABC-ATPase subunit interface; other site
1116391007110	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1116391007111	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
1116391007112	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391007113	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391007114	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391007115	active site
1116391007116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391007117	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391007118	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391007119	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1116391007120	substrate binding site [chemical binding]; other site
1116391007121	catalytic residues [active]
1116391007122	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
1116391007123	putative hydrophobic ligand binding site [chemical binding]; other site
1116391007124	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007125	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007126	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007127	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007128	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007130	dimer interface [polypeptide binding]; other site
1116391007131	conserved gate region; other site
1116391007132	putative PBP binding loops; other site
1116391007133	ABC-ATPase subunit interface; other site
1116391007134	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007136	dimer interface [polypeptide binding]; other site
1116391007137	conserved gate region; other site
1116391007138	putative PBP binding loops; other site
1116391007139	ABC-ATPase subunit interface; other site
1116391007140	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1116391007141	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1116391007142	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
1116391007143	putative active site [active]
1116391007144	putative catalytic site [active]
1116391007145	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007146	HAMP domain; Region: HAMP; pfam00672
1116391007147	Histidine kinase; Region: His_kinase; pfam06580
1116391007148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007149	ATP binding site [chemical binding]; other site
1116391007150	Mg2+ binding site [ion binding]; other site
1116391007151	G-X-G motif; other site
1116391007152	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391007153	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007154	active site
1116391007155	phosphorylation site [posttranslational modification]
1116391007156	intermolecular recognition site; other site
1116391007157	dimerization interface [polypeptide binding]; other site
1116391007158	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007159	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007160	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007161	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007162	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007164	putative PBP binding loops; other site
1116391007165	dimer interface [polypeptide binding]; other site
1116391007166	ABC-ATPase subunit interface; other site
1116391007167	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007168	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007169	dimer interface [polypeptide binding]; other site
1116391007170	conserved gate region; other site
1116391007171	putative PBP binding loops; other site
1116391007172	ABC-ATPase subunit interface; other site
1116391007173	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391007174	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391007175	HTH-like domain; Region: HTH_21; pfam13276
1116391007176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391007177	Integrase core domain; Region: rve; pfam00665
1116391007178	Integrase core domain; Region: rve_3; pfam13683
1116391007179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391007180	Transposase; Region: HTH_Tnp_1; cl17663
1116391007181	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391007182	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391007183	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391007184	Histidine kinase; Region: HisKA_3; pfam07730
1116391007185	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391007186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007187	active site
1116391007188	phosphorylation site [posttranslational modification]
1116391007189	intermolecular recognition site; other site
1116391007190	dimerization interface [polypeptide binding]; other site
1116391007191	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391007192	DNA binding residues [nucleotide binding]
1116391007193	dimerization interface [polypeptide binding]; other site
1116391007194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391007195	putative substrate translocation pore; other site
1116391007196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391007197	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391007198	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391007199	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391007200	dimerization interface [polypeptide binding]; other site
1116391007201	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391007202	Coenzyme A binding pocket [chemical binding]; other site
1116391007203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391007204	S-adenosylmethionine binding site [chemical binding]; other site
1116391007205	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
1116391007206	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1116391007207	DNA-binding site [nucleotide binding]; DNA binding site
1116391007208	RNA-binding motif; other site
1116391007209	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1116391007210	GRAS family transcription factor; Region: GRAS; pfam03514
1116391007211	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007212	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391007213	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007214	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007215	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007216	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007217	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391007218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007219	dimer interface [polypeptide binding]; other site
1116391007220	conserved gate region; other site
1116391007221	putative PBP binding loops; other site
1116391007222	ABC-ATPase subunit interface; other site
1116391007223	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007225	dimer interface [polypeptide binding]; other site
1116391007226	conserved gate region; other site
1116391007227	putative PBP binding loops; other site
1116391007228	ABC-ATPase subunit interface; other site
1116391007229	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1116391007230	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1116391007231	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391007232	HTH domain; Region: HTH_11; pfam08279
1116391007233	WYL domain; Region: WYL; pfam13280
1116391007234	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1116391007235	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391007236	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1116391007237	active site
1116391007238	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391007239	S-adenosylmethionine binding site [chemical binding]; other site
1116391007240	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1116391007241	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391007242	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1116391007243	dimer interface [polypeptide binding]; other site
1116391007244	putative metal binding site [ion binding]; other site
1116391007245	LysE type translocator; Region: LysE; pfam01810
1116391007246	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
1116391007247	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391007248	Coenzyme A binding pocket [chemical binding]; other site
1116391007249	AAA domain; Region: AAA_18; pfam13238
1116391007250	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1116391007251	active site
1116391007252	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1116391007253	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1116391007254	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391007255	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391007256	ABC transporter; Region: ABC_tran_2; pfam12848
1116391007257	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391007258	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1116391007259	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1116391007260	EamA-like transporter family; Region: EamA; pfam00892
1116391007261	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1116391007262	EamA-like transporter family; Region: EamA; pfam00892
1116391007263	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1116391007264	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391007265	DNA binding residues [nucleotide binding]
1116391007266	putative dimer interface [polypeptide binding]; other site
1116391007267	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1116391007268	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1116391007269	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1116391007270	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1116391007271	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391007272	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391007273	active site
1116391007274	catalytic tetrad [active]
1116391007275	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391007276	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391007277	active site
1116391007278	catalytic triad [active]
1116391007279	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391007280	Cytochrome P450; Region: p450; pfam00067
1116391007281	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1116391007282	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391007283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007284	active site
1116391007285	phosphorylation site [posttranslational modification]
1116391007286	intermolecular recognition site; other site
1116391007287	dimerization interface [polypeptide binding]; other site
1116391007288	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391007289	DNA binding site [nucleotide binding]
1116391007290	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391007292	dimer interface [polypeptide binding]; other site
1116391007293	phosphorylation site [posttranslational modification]
1116391007294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007295	ATP binding site [chemical binding]; other site
1116391007296	Mg2+ binding site [ion binding]; other site
1116391007297	G-X-G motif; other site
1116391007298	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391007299	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1116391007300	Walker A/P-loop; other site
1116391007301	ATP binding site [chemical binding]; other site
1116391007302	Q-loop/lid; other site
1116391007303	ABC transporter signature motif; other site
1116391007304	Walker B; other site
1116391007305	D-loop; other site
1116391007306	H-loop/switch region; other site
1116391007307	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1116391007308	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1116391007309	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1116391007310	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1116391007311	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1116391007312	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391007313	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391007314	dimerization interface [polypeptide binding]; other site
1116391007315	putative DNA binding site [nucleotide binding]; other site
1116391007316	putative Zn2+ binding site [ion binding]; other site
1116391007317	EamA-like transporter family; Region: EamA; pfam00892
1116391007318	EamA-like transporter family; Region: EamA; pfam00892
1116391007319	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391007320	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391007321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391007322	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391007323	putative substrate translocation pore; other site
1116391007324	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391007325	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391007326	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
1116391007327	substrate binding site [chemical binding]; other site
1116391007328	active site
1116391007329	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1116391007330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1116391007331	DinB superfamily; Region: DinB_2; pfam12867
1116391007332	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1116391007333	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391007334	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1116391007335	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1116391007336	classical (c) SDRs; Region: SDR_c; cd05233
1116391007337	NAD(P) binding site [chemical binding]; other site
1116391007338	active site
1116391007339	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391007340	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391007341	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391007342	salt bridge; other site
1116391007343	non-specific DNA binding site [nucleotide binding]; other site
1116391007344	sequence-specific DNA binding site [nucleotide binding]; other site
1116391007345	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391007346	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1116391007347	NAD(P) binding site [chemical binding]; other site
1116391007348	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1116391007349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391007350	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391007351	Coenzyme A binding pocket [chemical binding]; other site
1116391007352	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391007353	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391007354	oligoendopeptidase F; Region: pepF; TIGR00181
1116391007355	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1116391007356	active site
1116391007357	Zn binding site [ion binding]; other site
1116391007358	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391007359	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1116391007360	NAD(P) binding site [chemical binding]; other site
1116391007361	short chain dehydrogenase; Provisional; Region: PRK07677
1116391007362	substrate binding site [chemical binding]; other site
1116391007363	homotetramer interface [polypeptide binding]; other site
1116391007364	active site
1116391007365	homodimer interface [polypeptide binding]; other site
1116391007366	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391007367	active site
1116391007368	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391007369	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391007370	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391007371	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391007372	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391007373	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391007374	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391007375	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391007376	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391007377	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391007378	Interdomain contacts; other site
1116391007379	Cytokine receptor motif; other site
1116391007380	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391007381	dockerin binding interface; other site
1116391007382	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007383	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391007384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007385	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007386	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391007387	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391007388	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391007389	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391007390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007391	active site
1116391007392	phosphorylation site [posttranslational modification]
1116391007393	intermolecular recognition site; other site
1116391007394	dimerization interface [polypeptide binding]; other site
1116391007395	LytTr DNA-binding domain; Region: LytTR; pfam04397
1116391007396	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007398	ATP binding site [chemical binding]; other site
1116391007399	Mg2+ binding site [ion binding]; other site
1116391007400	G-X-G motif; other site
1116391007401	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1116391007402	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391007403	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1116391007404	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391007405	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391007406	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391007407	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391007408	DNA-binding site [nucleotide binding]; DNA binding site
1116391007409	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391007410	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391007411	homodimer interface [polypeptide binding]; other site
1116391007412	catalytic residue [active]
1116391007413	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
1116391007414	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007415	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007416	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007417	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007418	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391007419	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1116391007420	NAD(P) binding site [chemical binding]; other site
1116391007421	active site
1116391007422	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1116391007423	conserved cys residue [active]
1116391007424	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007425	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007426	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007427	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1116391007428	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391007429	tellurite resistance protein TehB; Provisional; Region: PRK11207
1116391007430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391007431	S-adenosylmethionine binding site [chemical binding]; other site
1116391007432	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
1116391007433	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391007434	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391007435	Coenzyme A binding pocket [chemical binding]; other site
1116391007436	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391007437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391007438	NAD(P) binding site [chemical binding]; other site
1116391007439	active site
1116391007440	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391007441	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1116391007442	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1116391007443	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1116391007444	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1116391007445	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391007446	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391007447	S-layer homology domain; Region: SLH; pfam00395
1116391007448	S-layer homology domain; Region: SLH; pfam00395
1116391007449	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391007450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007451	active site
1116391007452	phosphorylation site [posttranslational modification]
1116391007453	intermolecular recognition site; other site
1116391007454	dimerization interface [polypeptide binding]; other site
1116391007455	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391007456	DNA binding site [nucleotide binding]
1116391007457	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007458	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007459	dimerization interface [polypeptide binding]; other site
1116391007460	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391007461	dimer interface [polypeptide binding]; other site
1116391007462	phosphorylation site [posttranslational modification]
1116391007463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007464	ATP binding site [chemical binding]; other site
1116391007465	Mg2+ binding site [ion binding]; other site
1116391007466	G-X-G motif; other site
1116391007467	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1116391007468	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1116391007469	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1116391007470	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1116391007471	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1116391007472	Helix-turn-helix domain; Region: HTH_31; pfam13560
1116391007473	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1116391007474	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1116391007475	NADP binding site [chemical binding]; other site
1116391007476	substrate binding site [chemical binding]; other site
1116391007477	active site
1116391007478	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1116391007479	homotrimer interaction site [polypeptide binding]; other site
1116391007480	putative active site [active]
1116391007481	LysE type translocator; Region: LysE; cl00565
1116391007482	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007483	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007484	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007485	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1116391007486	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391007487	DNA binding residues [nucleotide binding]
1116391007488	putative dimer interface [polypeptide binding]; other site
1116391007489	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1116391007490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391007491	NAD(P) binding site [chemical binding]; other site
1116391007492	active site
1116391007493	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391007494	short chain dehydrogenase; Provisional; Region: PRK07454
1116391007495	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1116391007496	NADP binding site [chemical binding]; other site
1116391007497	substrate binding site [chemical binding]; other site
1116391007498	active site
1116391007499	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1116391007500	nudix motif; other site
1116391007501	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391007502	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391007503	Coenzyme A binding pocket [chemical binding]; other site
1116391007504	EamA-like transporter family; Region: EamA; pfam00892
1116391007505	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1116391007506	EamA-like transporter family; Region: EamA; cl17759
1116391007507	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
1116391007508	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1116391007509	MOSC domain; Region: MOSC; pfam03473
1116391007510	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1116391007511	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391007512	putative homodimer interface [polypeptide binding]; other site
1116391007513	Sm and related proteins; Region: Sm_like; cl00259
1116391007514	heptamer interface [polypeptide binding]; other site
1116391007515	Sm1 motif; other site
1116391007516	hexamer interface [polypeptide binding]; other site
1116391007517	RNA binding site [nucleotide binding]; other site
1116391007518	Sm2 motif; other site
1116391007519	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1116391007520	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391007521	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391007522	Transposase; Region: HTH_Tnp_1; cl17663
1116391007523	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391007524	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391007525	HTH-like domain; Region: HTH_21; pfam13276
1116391007526	Integrase core domain; Region: rve; pfam00665
1116391007527	Integrase core domain; Region: rve_2; pfam13333
1116391007528	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
1116391007529	DHH family; Region: DHH; pfam01368
1116391007530	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391007531	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391007532	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391007533	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391007534	putative substrate translocation pore; other site
1116391007535	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1116391007536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007537	active site
1116391007538	phosphorylation site [posttranslational modification]
1116391007539	intermolecular recognition site; other site
1116391007540	dimerization interface [polypeptide binding]; other site
1116391007541	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1116391007542	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007543	ATP binding site [chemical binding]; other site
1116391007544	Mg2+ binding site [ion binding]; other site
1116391007545	G-X-G motif; other site
1116391007546	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1116391007547	Citrate transporter; Region: CitMHS; pfam03600
1116391007548	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1116391007549	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1116391007550	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1116391007551	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1116391007552	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1116391007553	active site
1116391007554	substrate-binding site [chemical binding]; other site
1116391007555	metal-binding site [ion binding]
1116391007556	ATP binding site [chemical binding]; other site
1116391007557	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1116391007558	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391007559	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391007560	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391007561	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391007562	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391007563	DNA binding site [nucleotide binding]
1116391007564	domain linker motif; other site
1116391007565	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391007566	dimerization interface [polypeptide binding]; other site
1116391007567	ligand binding site [chemical binding]; other site
1116391007568	High-affinity nickel-transport protein; Region: NicO; cl00964
1116391007569	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007570	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007571	dimerization interface [polypeptide binding]; other site
1116391007572	Histidine kinase; Region: His_kinase; pfam06580
1116391007573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007574	ATP binding site [chemical binding]; other site
1116391007575	Mg2+ binding site [ion binding]; other site
1116391007576	G-X-G motif; other site
1116391007577	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391007578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007579	active site
1116391007580	phosphorylation site [posttranslational modification]
1116391007581	intermolecular recognition site; other site
1116391007582	dimerization interface [polypeptide binding]; other site
1116391007583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007584	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391007585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007586	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007587	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007589	dimer interface [polypeptide binding]; other site
1116391007590	conserved gate region; other site
1116391007591	putative PBP binding loops; other site
1116391007592	ABC-ATPase subunit interface; other site
1116391007593	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007595	dimer interface [polypeptide binding]; other site
1116391007596	conserved gate region; other site
1116391007597	putative PBP binding loops; other site
1116391007598	ABC-ATPase subunit interface; other site
1116391007599	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1116391007600	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1116391007601	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391007602	PAS domain; Region: PAS; smart00091
1116391007603	PAS domain; Region: PAS_9; pfam13426
1116391007604	putative active site [active]
1116391007605	heme pocket [chemical binding]; other site
1116391007606	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391007607	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391007608	metal binding site [ion binding]; metal-binding site
1116391007609	active site
1116391007610	I-site; other site
1116391007611	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391007612	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1116391007613	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1116391007614	PYR/PP interface [polypeptide binding]; other site
1116391007615	dimer interface [polypeptide binding]; other site
1116391007616	TPP binding site [chemical binding]; other site
1116391007617	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391007618	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1116391007619	TPP-binding site [chemical binding]; other site
1116391007620	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1116391007621	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1116391007622	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1116391007623	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1116391007624	PYR/PP interface [polypeptide binding]; other site
1116391007625	dimer interface [polypeptide binding]; other site
1116391007626	TPP binding site [chemical binding]; other site
1116391007627	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391007628	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1116391007629	TPP-binding site [chemical binding]; other site
1116391007630	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1116391007631	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391007632	putative active site [active]
1116391007633	heme pocket [chemical binding]; other site
1116391007634	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391007635	dimer interface [polypeptide binding]; other site
1116391007636	phosphorylation site [posttranslational modification]
1116391007637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007638	ATP binding site [chemical binding]; other site
1116391007639	Mg2+ binding site [ion binding]; other site
1116391007640	G-X-G motif; other site
1116391007641	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391007642	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391007643	Walker A/P-loop; other site
1116391007644	ATP binding site [chemical binding]; other site
1116391007645	Q-loop/lid; other site
1116391007646	ABC transporter signature motif; other site
1116391007647	Walker B; other site
1116391007648	D-loop; other site
1116391007649	H-loop/switch region; other site
1116391007650	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391007651	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007652	dimer interface [polypeptide binding]; other site
1116391007653	conserved gate region; other site
1116391007654	putative PBP binding loops; other site
1116391007655	ABC-ATPase subunit interface; other site
1116391007656	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391007657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007658	ABC-ATPase subunit interface; other site
1116391007659	putative PBP binding loops; other site
1116391007660	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1116391007661	NMT1/THI5 like; Region: NMT1; pfam09084
1116391007662	aminotransferase; Validated; Region: PRK07678
1116391007663	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391007664	inhibitor-cofactor binding pocket; inhibition site
1116391007665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391007666	catalytic residue [active]
1116391007667	allantoate amidohydrolase; Reviewed; Region: PRK09290
1116391007668	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1116391007669	active site
1116391007670	metal binding site [ion binding]; metal-binding site
1116391007671	dimer interface [polypeptide binding]; other site
1116391007672	mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568
1116391007673	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1116391007674	putative active site [active]
1116391007675	catalytic triad [active]
1116391007676	multimer interface [polypeptide binding]; other site
1116391007677	dimer interface [polypeptide binding]; other site
1116391007678	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1116391007679	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1116391007680	homodimer interface [polypeptide binding]; other site
1116391007681	active site
1116391007682	FMN binding site [chemical binding]; other site
1116391007683	substrate binding site [chemical binding]; other site
1116391007684	4Fe-4S binding domain; Region: Fer4; pfam00037
1116391007685	phenylhydantoinase; Validated; Region: PRK08323
1116391007686	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1116391007687	tetramer interface [polypeptide binding]; other site
1116391007688	active site
1116391007689	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1116391007690	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1116391007691	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1116391007692	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1116391007693	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1116391007694	NAD(P) binding site [chemical binding]; other site
1116391007695	catalytic residues [active]
1116391007696	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1116391007697	Cache domain; Region: Cache_1; pfam02743
1116391007698	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007699	dimerization interface [polypeptide binding]; other site
1116391007700	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391007701	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391007702	dimer interface [polypeptide binding]; other site
1116391007703	putative CheW interface [polypeptide binding]; other site
1116391007704	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391007705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391007706	putative DNA binding site [nucleotide binding]; other site
1116391007707	putative Zn2+ binding site [ion binding]; other site
1116391007708	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1116391007709	substrate binding site [chemical binding]; other site
1116391007710	active site
1116391007711	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391007712	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391007713	S-adenosylmethionine binding site [chemical binding]; other site
1116391007714	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391007715	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391007716	DNA binding residues [nucleotide binding]
1116391007717	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391007718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391007719	S-adenosylmethionine binding site [chemical binding]; other site
1116391007720	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391007721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007722	dimer interface [polypeptide binding]; other site
1116391007723	conserved gate region; other site
1116391007724	putative PBP binding loops; other site
1116391007725	ABC-ATPase subunit interface; other site
1116391007726	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391007727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391007728	dimer interface [polypeptide binding]; other site
1116391007729	conserved gate region; other site
1116391007730	putative PBP binding loops; other site
1116391007731	ABC-ATPase subunit interface; other site
1116391007732	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391007733	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391007734	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391007735	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007736	active site
1116391007737	phosphorylation site [posttranslational modification]
1116391007738	intermolecular recognition site; other site
1116391007739	dimerization interface [polypeptide binding]; other site
1116391007740	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007741	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007742	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007743	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007744	dimerization interface [polypeptide binding]; other site
1116391007745	Histidine kinase; Region: His_kinase; pfam06580
1116391007746	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007747	ATP binding site [chemical binding]; other site
1116391007748	Mg2+ binding site [ion binding]; other site
1116391007749	G-X-G motif; other site
1116391007750	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391007751	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391007752	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391007753	dimerization interface [polypeptide binding]; other site
1116391007754	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1116391007755	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1116391007756	homodimer interface [polypeptide binding]; other site
1116391007757	substrate-cofactor binding pocket; other site
1116391007758	catalytic residue [active]
1116391007759	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391007760	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248
1116391007761	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1116391007762	homodimer interface [polypeptide binding]; other site
1116391007763	substrate-cofactor binding pocket; other site
1116391007764	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391007765	catalytic residue [active]
1116391007766	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391007767	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1116391007768	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1116391007769	Walker A/P-loop; other site
1116391007770	ATP binding site [chemical binding]; other site
1116391007771	Q-loop/lid; other site
1116391007772	ABC transporter signature motif; other site
1116391007773	Walker B; other site
1116391007774	D-loop; other site
1116391007775	H-loop/switch region; other site
1116391007776	Predicted transcriptional regulators [Transcription]; Region: COG1725
1116391007777	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391007778	DNA-binding site [nucleotide binding]; DNA binding site
1116391007779	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1116391007780	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391007781	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1116391007782	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1116391007783	dimanganese center [ion binding]; other site
1116391007784	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1116391007785	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1116391007786	active site
1116391007787	Pirin-related protein [General function prediction only]; Region: COG1741
1116391007788	Pirin; Region: Pirin; pfam02678
1116391007789	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1116391007790	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1116391007791	aspartate racemase; Region: asp_race; TIGR00035
1116391007792	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391007793	Spore germination protein; Region: Spore_permease; cl17796
1116391007794	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391007795	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391007796	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1116391007797	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391007798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391007799	dimer interface [polypeptide binding]; other site
1116391007800	phosphorylation site [posttranslational modification]
1116391007801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007802	ATP binding site [chemical binding]; other site
1116391007803	Mg2+ binding site [ion binding]; other site
1116391007804	G-X-G motif; other site
1116391007805	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391007806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007807	active site
1116391007808	phosphorylation site [posttranslational modification]
1116391007809	intermolecular recognition site; other site
1116391007810	dimerization interface [polypeptide binding]; other site
1116391007811	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391007812	Histidine kinase; Region: HisKA_3; pfam07730
1116391007813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391007814	ATP binding site [chemical binding]; other site
1116391007815	Mg2+ binding site [ion binding]; other site
1116391007816	G-X-G motif; other site
1116391007817	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007818	dimerization interface [polypeptide binding]; other site
1116391007819	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391007820	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391007821	dimer interface [polypeptide binding]; other site
1116391007822	putative CheW interface [polypeptide binding]; other site
1116391007823	L-arabinose isomerase; Provisional; Region: PRK02929
1116391007824	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1116391007825	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1116391007826	trimer interface [polypeptide binding]; other site
1116391007827	putative substrate binding site [chemical binding]; other site
1116391007828	putative metal binding site [ion binding]; other site
1116391007829	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1116391007830	active site
1116391007831	catalytic residues [active]
1116391007832	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
1116391007833	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
1116391007834	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1116391007835	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391007836	Cache domain; Region: Cache_1; pfam02743
1116391007837	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391007838	dimerization interface [polypeptide binding]; other site
1116391007839	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391007840	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391007841	dimer interface [polypeptide binding]; other site
1116391007842	putative CheW interface [polypeptide binding]; other site
1116391007843	Clp protease; Region: CLP_protease; pfam00574
1116391007844	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1116391007845	oligomer interface [polypeptide binding]; other site
1116391007846	active site residues [active]
1116391007847	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391007848	putative DNA binding site [nucleotide binding]; other site
1116391007849	putative Zn2+ binding site [ion binding]; other site
1116391007850	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1116391007851	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
1116391007852	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391007853	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391007854	Initiator Replication protein; Region: Rep_3; pfam01051
1116391007855	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391007856	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391007857	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1116391007858	beta-galactosidase; Region: BGL; TIGR03356
1116391007859	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391007860	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391007861	DNA binding site [nucleotide binding]
1116391007862	domain linker motif; other site
1116391007863	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1116391007864	putative dimerization interface [polypeptide binding]; other site
1116391007865	putative ligand binding site [chemical binding]; other site
1116391007866	DoxX; Region: DoxX; cl17842
1116391007867	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391007868	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391007869	Alginate lyase; Region: Alginate_lyase; pfam05426
1116391007870	Bacterial SH3 domain; Region: SH3_3; pfam08239
1116391007871	Bacterial SH3 domain; Region: SH3_3; pfam08239
1116391007872	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391007873	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391007874	hypothetical protein; Provisional; Region: PRK02237
1116391007875	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1116391007876	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
1116391007877	putative ligand binding site [chemical binding]; other site
1116391007878	CHASE3 domain; Region: CHASE3; cl05000
1116391007879	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1116391007880	HAMP domain; Region: HAMP; pfam00672
1116391007881	dimerization interface [polypeptide binding]; other site
1116391007882	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391007883	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391007884	dimer interface [polypeptide binding]; other site
1116391007885	putative CheW interface [polypeptide binding]; other site
1116391007886	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1116391007887	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1116391007888	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1116391007889	PAS domain S-box; Region: sensory_box; TIGR00229
1116391007890	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391007891	putative active site [active]
1116391007892	heme pocket [chemical binding]; other site
1116391007893	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391007894	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391007895	metal binding site [ion binding]; metal-binding site
1116391007896	active site
1116391007897	I-site; other site
1116391007898	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391007899	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391007900	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391007901	DNA binding site [nucleotide binding]
1116391007902	domain linker motif; other site
1116391007903	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391007904	dimerization interface [polypeptide binding]; other site
1116391007905	ligand binding site [chemical binding]; other site
1116391007906	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391007907	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391007908	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391007909	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391007910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391007911	active site
1116391007912	phosphorylation site [posttranslational modification]
1116391007913	intermolecular recognition site; other site
1116391007914	dimerization interface [polypeptide binding]; other site
1116391007915	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1116391007916	metal-dependent hydrolase; Provisional; Region: PRK00685
1116391007917	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391007918	Coenzyme A binding pocket [chemical binding]; other site
1116391007919	PAS domain S-box; Region: sensory_box; TIGR00229
1116391007920	PAS domain; Region: PAS; smart00091
1116391007921	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391007922	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391007923	metal binding site [ion binding]; metal-binding site
1116391007924	active site
1116391007925	I-site; other site
1116391007926	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391007927	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1116391007928	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391007929	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391007930	Walker A/P-loop; other site
1116391007931	ATP binding site [chemical binding]; other site
1116391007932	Q-loop/lid; other site
1116391007933	ABC transporter signature motif; other site
1116391007934	Walker B; other site
1116391007935	D-loop; other site
1116391007936	H-loop/switch region; other site
1116391007937	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391007938	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391007939	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391007940	Walker A/P-loop; other site
1116391007941	ATP binding site [chemical binding]; other site
1116391007942	Q-loop/lid; other site
1116391007943	ABC transporter signature motif; other site
1116391007944	Walker B; other site
1116391007945	D-loop; other site
1116391007946	H-loop/switch region; other site
1116391007947	histidyl-tRNA synthetase; Region: hisS; TIGR00442
1116391007948	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1116391007949	dimer interface [polypeptide binding]; other site
1116391007950	motif 1; other site
1116391007951	active site
1116391007952	motif 2; other site
1116391007953	motif 3; other site
1116391007954	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1116391007955	anticodon binding site; other site
1116391007956	Sulfatase; Region: Sulfatase; pfam00884
1116391007957	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1116391007958	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
1116391007959	GIY-YIG motif/motif A; other site
1116391007960	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1116391007961	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1116391007962	phosphopeptide binding site; other site
1116391007963	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391007964	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1116391007965	DNA binding site [nucleotide binding]
1116391007966	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1116391007967	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1116391007968	hinge; other site
1116391007969	active site
1116391007970	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1116391007971	active site
1116391007972	multimer interface [polypeptide binding]; other site
1116391007973	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1116391007974	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1116391007975	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391007976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007977	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391007978	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391007979	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391007980	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391007981	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391007982	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1116391007983	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1116391007984	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1116391007985	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391007986	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1116391007987	putative dimerization interface [polypeptide binding]; other site
1116391007988	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1116391007989	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1116391007990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391007991	NAD(P) binding site [chemical binding]; other site
1116391007992	active site
1116391007993	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1116391007994	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1116391007995	putative acyltransferase; Provisional; Region: PRK05790
1116391007996	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1116391007997	dimer interface [polypeptide binding]; other site
1116391007998	active site
1116391007999	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391008000	Cytochrome P450; Region: p450; cl12078
1116391008001	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1116391008002	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1116391008003	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1116391008004	Mg++ binding site [ion binding]; other site
1116391008005	putative catalytic motif [active]
1116391008006	substrate binding site [chemical binding]; other site
1116391008007	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391008008	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391008009	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391008010	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391008011	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1116391008012	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1116391008013	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1116391008014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391008015	dimer interface [polypeptide binding]; other site
1116391008016	conserved gate region; other site
1116391008017	ABC-ATPase subunit interface; other site
1116391008018	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1116391008019	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1116391008020	Walker A/P-loop; other site
1116391008021	ATP binding site [chemical binding]; other site
1116391008022	Q-loop/lid; other site
1116391008023	ABC transporter signature motif; other site
1116391008024	Walker B; other site
1116391008025	D-loop; other site
1116391008026	H-loop/switch region; other site
1116391008027	selenophosphate synthetase; Provisional; Region: PRK00943
1116391008028	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1116391008029	dimerization interface [polypeptide binding]; other site
1116391008030	putative ATP binding site [chemical binding]; other site
1116391008031	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1116391008032	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1116391008033	active site residue [active]
1116391008034	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391008035	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391008036	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1116391008037	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1116391008038	NAD(P) binding site [chemical binding]; other site
1116391008039	catalytic residues [active]
1116391008040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1116391008041	short chain dehydrogenase; Provisional; Region: PRK06701
1116391008042	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1116391008043	NAD binding site [chemical binding]; other site
1116391008044	metal binding site [ion binding]; metal-binding site
1116391008045	active site
1116391008046	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1116391008047	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391008048	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1116391008049	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1116391008050	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391008051	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391008052	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391008053	Walker A/P-loop; other site
1116391008054	ATP binding site [chemical binding]; other site
1116391008055	Q-loop/lid; other site
1116391008056	ABC transporter signature motif; other site
1116391008057	Walker B; other site
1116391008058	D-loop; other site
1116391008059	H-loop/switch region; other site
1116391008060	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1116391008061	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1116391008062	FtsX-like permease family; Region: FtsX; pfam02687
1116391008063	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1116391008064	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1116391008065	Chromate transporter; Region: Chromate_transp; pfam02417
1116391008066	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391008067	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391008068	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1116391008069	zinc binding site [ion binding]; other site
1116391008070	putative ligand binding site [chemical binding]; other site
1116391008071	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391008072	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1116391008073	TM-ABC transporter signature motif; other site
1116391008074	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1116391008075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391008076	Walker A/P-loop; other site
1116391008077	ATP binding site [chemical binding]; other site
1116391008078	Q-loop/lid; other site
1116391008079	ABC transporter signature motif; other site
1116391008080	Walker B; other site
1116391008081	D-loop; other site
1116391008082	H-loop/switch region; other site
1116391008083	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1116391008084	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391008085	dimerization interface [polypeptide binding]; other site
1116391008086	putative DNA binding site [nucleotide binding]; other site
1116391008087	putative Zn2+ binding site [ion binding]; other site
1116391008088	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1116391008089	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1116391008090	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1116391008091	active site
1116391008092	Protein of unknown function (DUF962); Region: DUF962; pfam06127
1116391008093	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1116391008094	rod shape-determining protein MreB; Provisional; Region: PRK13927
1116391008095	MreB and similar proteins; Region: MreB_like; cd10225
1116391008096	nucleotide binding site [chemical binding]; other site
1116391008097	Mg binding site [ion binding]; other site
1116391008098	putative protofilament interaction site [polypeptide binding]; other site
1116391008099	RodZ interaction site [polypeptide binding]; other site
1116391008100	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391008101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391008102	active site
1116391008103	phosphorylation site [posttranslational modification]
1116391008104	intermolecular recognition site; other site
1116391008105	dimerization interface [polypeptide binding]; other site
1116391008106	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391008107	DNA binding site [nucleotide binding]
1116391008108	Haemolytic domain; Region: Haemolytic; pfam01809
1116391008109	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1116391008110	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1116391008111	active site
1116391008112	HIGH motif; other site
1116391008113	KMSKS motif; other site
1116391008114	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1116391008115	tRNA binding surface [nucleotide binding]; other site
1116391008116	anticodon binding site; other site
1116391008117	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1116391008118	dimer interface [polypeptide binding]; other site
1116391008119	putative tRNA-binding site [nucleotide binding]; other site
1116391008120	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391008121	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391008122	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391008123	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
1116391008124	glycogen binding site [chemical binding]; other site
1116391008125	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1116391008126	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
1116391008127	active site
1116391008128	catalytic site [active]
1116391008129	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1116391008130	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1116391008131	metal binding site [ion binding]; metal-binding site
1116391008132	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391008133	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1116391008134	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1116391008135	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391008136	ABC-ATPase subunit  interface; other site
1116391008137	dimer interface [polypeptide binding]; other site
1116391008138	putative PBP binding regions; other site
1116391008139	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1116391008140	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1116391008141	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1116391008142	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391008143	FeS/SAM binding site; other site
1116391008144	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1116391008145	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1116391008146	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1116391008147	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1116391008148	active site
1116391008149	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1116391008150	nucleophile elbow; other site
1116391008151	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
1116391008152	Conserved membrane protein YqhR; Region: YqhR; pfam11085
1116391008153	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1116391008154	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1116391008155	trimer interface [polypeptide binding]; other site
1116391008156	active site
1116391008157	dimer interface [polypeptide binding]; other site
1116391008158	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1116391008159	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1116391008160	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1116391008161	active site
1116391008162	elongation factor P; Validated; Region: PRK00529
1116391008163	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1116391008164	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1116391008165	RNA binding site [nucleotide binding]; other site
1116391008166	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1116391008167	RNA binding site [nucleotide binding]; other site
1116391008168	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1116391008169	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391008170	DNA-binding site [nucleotide binding]; DNA binding site
1116391008171	DRTGG domain; Region: DRTGG; pfam07085
1116391008172	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1116391008173	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1116391008174	active site 2 [active]
1116391008175	active site 1 [active]
1116391008176	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1116391008177	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1116391008178	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391008179	motif II; other site
1116391008180	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1116391008181	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1116391008182	aspartate kinase; Reviewed; Region: PRK06635
1116391008183	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1116391008184	putative nucleotide binding site [chemical binding]; other site
1116391008185	putative catalytic residues [active]
1116391008186	putative Mg ion binding site [ion binding]; other site
1116391008187	putative aspartate binding site [chemical binding]; other site
1116391008188	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1116391008189	putative allosteric regulatory site; other site
1116391008190	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1116391008191	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1116391008192	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
1116391008193	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
1116391008194	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
1116391008195	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
1116391008196	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
1116391008197	NTPase; Region: NTPase_1; cl17478
1116391008198	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
1116391008199	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
1116391008200	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
1116391008201	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
1116391008202	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1116391008203	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1116391008204	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1116391008205	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1116391008206	carboxyltransferase (CT) interaction site; other site
1116391008207	biotinylation site [posttranslational modification]; other site
1116391008208	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1116391008209	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1116391008210	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1116391008211	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1116391008212	Asp23 family; Region: Asp23; pfam03780
1116391008213	Asp23 family; Region: Asp23; pfam03780
1116391008214	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
1116391008215	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1116391008216	putative RNA binding site [nucleotide binding]; other site
1116391008217	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1116391008218	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1116391008219	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1116391008220	homodimer interface [polypeptide binding]; other site
1116391008221	NADP binding site [chemical binding]; other site
1116391008222	substrate binding site [chemical binding]; other site
1116391008223	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1116391008224	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1116391008225	generic binding surface II; other site
1116391008226	generic binding surface I; other site
1116391008227	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1116391008228	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1116391008229	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1116391008230	substrate binding pocket [chemical binding]; other site
1116391008231	chain length determination region; other site
1116391008232	substrate-Mg2+ binding site; other site
1116391008233	catalytic residues [active]
1116391008234	aspartate-rich region 1; other site
1116391008235	active site lid residues [active]
1116391008236	aspartate-rich region 2; other site
1116391008237	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391008238	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1116391008239	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391008240	RNA binding surface [nucleotide binding]; other site
1116391008241	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1116391008242	arginine repressor; Provisional; Region: PRK04280
1116391008243	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1116391008244	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1116391008245	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1116391008246	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1116391008247	Walker A/P-loop; other site
1116391008248	ATP binding site [chemical binding]; other site
1116391008249	Q-loop/lid; other site
1116391008250	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1116391008251	Q-loop/lid; other site
1116391008252	ABC transporter signature motif; other site
1116391008253	Walker B; other site
1116391008254	D-loop; other site
1116391008255	H-loop/switch region; other site
1116391008256	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1116391008257	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1116391008258	protein binding site [polypeptide binding]; other site
1116391008259	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1116391008260	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1116391008261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391008262	active site
1116391008263	phosphorylation site [posttranslational modification]
1116391008264	intermolecular recognition site; other site
1116391008265	dimerization interface [polypeptide binding]; other site
1116391008266	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1116391008267	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1116391008268	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
1116391008269	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1116391008270	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391008271	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1116391008272	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1116391008273	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1116391008274	tetramer interface [polypeptide binding]; other site
1116391008275	TPP-binding site [chemical binding]; other site
1116391008276	heterodimer interface [polypeptide binding]; other site
1116391008277	phosphorylation loop region [posttranslational modification]
1116391008278	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1116391008279	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1116391008280	alpha subunit interface [polypeptide binding]; other site
1116391008281	TPP binding site [chemical binding]; other site
1116391008282	heterodimer interface [polypeptide binding]; other site
1116391008283	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391008284	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1116391008285	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1116391008286	E3 interaction surface; other site
1116391008287	lipoyl attachment site [posttranslational modification]; other site
1116391008288	e3 binding domain; Region: E3_binding; pfam02817
1116391008289	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1116391008290	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1116391008291	peptidase T-like protein; Region: PepT-like; TIGR01883
1116391008292	metal binding site [ion binding]; metal-binding site
1116391008293	putative dimer interface [polypeptide binding]; other site
1116391008294	Protein of unknown function (DUF3936); Region: DUF3936; pfam13072
1116391008295	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1116391008296	dimer interface [polypeptide binding]; other site
1116391008297	ADP-ribose binding site [chemical binding]; other site
1116391008298	active site
1116391008299	nudix motif; other site
1116391008300	metal binding site [ion binding]; metal-binding site
1116391008301	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
1116391008302	PHP-associated; Region: PHP_C; pfam13263
1116391008303	Integral membrane protein DUF95; Region: DUF95; cl00572
1116391008304	ferric uptake regulator; Provisional; Region: fur; PRK09462
1116391008305	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1116391008306	metal binding site 2 [ion binding]; metal-binding site
1116391008307	putative DNA binding helix; other site
1116391008308	metal binding site 1 [ion binding]; metal-binding site
1116391008309	dimer interface [polypeptide binding]; other site
1116391008310	structural Zn2+ binding site [ion binding]; other site
1116391008311	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1116391008312	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1116391008313	hexamer interface [polypeptide binding]; other site
1116391008314	ligand binding site [chemical binding]; other site
1116391008315	putative active site [active]
1116391008316	NAD(P) binding site [chemical binding]; other site
1116391008317	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
1116391008318	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1116391008319	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1116391008320	active site
1116391008321	Int/Topo IB signature motif; other site
1116391008322	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1116391008323	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1116391008324	flagellar operon protein TIGR03826; Region: YvyF
1116391008325	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1116391008326	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1116391008327	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1116391008328	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1116391008329	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1116391008330	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1116391008331	anti sigma factor interaction site; other site
1116391008332	regulatory phosphorylation site [posttranslational modification]; other site
1116391008333	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1116391008334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391008335	ATP binding site [chemical binding]; other site
1116391008336	Mg2+ binding site [ion binding]; other site
1116391008337	G-X-G motif; other site
1116391008338	sporulation sigma factor SigF; Validated; Region: PRK05572
1116391008339	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391008340	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1116391008341	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391008342	DNA binding residues [nucleotide binding]
1116391008343	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1116391008344	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
1116391008345	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
1116391008346	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391008347	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1116391008348	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1116391008349	active site
1116391008350	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1116391008351	substrate binding site [chemical binding]; other site
1116391008352	catalytic residues [active]
1116391008353	dimer interface [polypeptide binding]; other site
1116391008354	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1116391008355	active site
1116391008356	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1116391008357	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1116391008358	catalytic motif [active]
1116391008359	Zn binding site [ion binding]; other site
1116391008360	RibD C-terminal domain; Region: RibD_C; cl17279
1116391008361	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1116391008362	Lumazine binding domain; Region: Lum_binding; pfam00677
1116391008363	Lumazine binding domain; Region: Lum_binding; pfam00677
1116391008364	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1116391008365	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1116391008366	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1116391008367	dimerization interface [polypeptide binding]; other site
1116391008368	active site
1116391008369	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1116391008370	homopentamer interface [polypeptide binding]; other site
1116391008371	active site
1116391008372	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1116391008373	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1116391008374	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1116391008375	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
1116391008376	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1116391008377	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1116391008378	PAS domain S-box; Region: sensory_box; TIGR00229
1116391008379	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391008380	putative active site [active]
1116391008381	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391008382	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391008383	metal binding site [ion binding]; metal-binding site
1116391008384	active site
1116391008385	I-site; other site
1116391008386	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391008387	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1116391008388	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1116391008389	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1116391008390	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1116391008391	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391008392	RNA binding surface [nucleotide binding]; other site
1116391008393	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1116391008394	active site
1116391008395	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1116391008396	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391008397	catalytic residues [active]
1116391008398	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1116391008399	ResB-like family; Region: ResB; pfam05140
1116391008400	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1116391008401	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1116391008402	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391008403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391008404	active site
1116391008405	phosphorylation site [posttranslational modification]
1116391008406	intermolecular recognition site; other site
1116391008407	dimerization interface [polypeptide binding]; other site
1116391008408	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391008409	DNA binding site [nucleotide binding]
1116391008410	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391008411	dimerization interface [polypeptide binding]; other site
1116391008412	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391008413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391008414	dimer interface [polypeptide binding]; other site
1116391008415	phosphorylation site [posttranslational modification]
1116391008416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391008417	ATP binding site [chemical binding]; other site
1116391008418	Mg2+ binding site [ion binding]; other site
1116391008419	G-X-G motif; other site
1116391008420	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1116391008421	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1116391008422	ligand binding site [chemical binding]; other site
1116391008423	NAD binding site [chemical binding]; other site
1116391008424	dimerization interface [polypeptide binding]; other site
1116391008425	catalytic site [active]
1116391008426	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1116391008427	putative L-serine binding site [chemical binding]; other site
1116391008428	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1116391008429	active site residue [active]
1116391008430	CAAX protease self-immunity; Region: Abi; pfam02517
1116391008431	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1116391008432	NodB motif; other site
1116391008433	active site
1116391008434	catalytic site [active]
1116391008435	metal binding site [ion binding]; metal-binding site
1116391008436	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
1116391008437	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1116391008438	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1116391008439	active site
1116391008440	interdomain interaction site; other site
1116391008441	metal binding site [ion binding]; metal-binding site
1116391008442	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
1116391008443	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1116391008444	Walker A motif; other site
1116391008445	ATP binding site [chemical binding]; other site
1116391008446	Walker B motif; other site
1116391008447	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1116391008448	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1116391008449	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1116391008450	NAD(P) binding site [chemical binding]; other site
1116391008451	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1116391008452	germination protein YpeB; Region: spore_YpeB; TIGR02889
1116391008453	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1116391008454	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1116391008455	PilZ domain; Region: PilZ; pfam07238
1116391008456	cytidylate kinase; Provisional; Region: cmk; PRK00023
1116391008457	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1116391008458	CMP-binding site; other site
1116391008459	The sites determining sugar specificity; other site
1116391008460	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1116391008461	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1116391008462	putative acyl-acceptor binding pocket; other site
1116391008463	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1116391008464	RNA binding site [nucleotide binding]; other site
1116391008465	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1116391008466	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1116391008467	RNA binding site [nucleotide binding]; other site
1116391008468	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1116391008469	RNA binding site [nucleotide binding]; other site
1116391008470	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1116391008471	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1116391008472	homotetramer interface [polypeptide binding]; other site
1116391008473	FMN binding site [chemical binding]; other site
1116391008474	homodimer contacts [polypeptide binding]; other site
1116391008475	putative active site [active]
1116391008476	putative substrate binding site [chemical binding]; other site
1116391008477	YIEGIA protein; Region: YIEGIA; pfam14045
1116391008478	GTP-binding protein Der; Reviewed; Region: PRK00093
1116391008479	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1116391008480	G1 box; other site
1116391008481	GTP/Mg2+ binding site [chemical binding]; other site
1116391008482	Switch I region; other site
1116391008483	G2 box; other site
1116391008484	Switch II region; other site
1116391008485	G3 box; other site
1116391008486	G4 box; other site
1116391008487	G5 box; other site
1116391008488	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1116391008489	G1 box; other site
1116391008490	GTP/Mg2+ binding site [chemical binding]; other site
1116391008491	Switch I region; other site
1116391008492	G2 box; other site
1116391008493	G3 box; other site
1116391008494	Switch II region; other site
1116391008495	G4 box; other site
1116391008496	G5 box; other site
1116391008497	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
1116391008498	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1116391008499	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1116391008500	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1116391008501	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1116391008502	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1116391008503	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1116391008504	catalytic loop [active]
1116391008505	iron binding site [ion binding]; other site
1116391008506	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1116391008507	metal binding triad [ion binding]; metal-binding site
1116391008508	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1116391008509	catalytic loop [active]
1116391008510	iron binding site [ion binding]; other site
1116391008511	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
1116391008512	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1116391008513	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1116391008514	G1 box; other site
1116391008515	GTP/Mg2+ binding site [chemical binding]; other site
1116391008516	G2 box; other site
1116391008517	Switch I region; other site
1116391008518	G3 box; other site
1116391008519	Switch II region; other site
1116391008520	G5 box; other site
1116391008521	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1116391008522	IHF - DNA interface [nucleotide binding]; other site
1116391008523	IHF dimer interface [polypeptide binding]; other site
1116391008524	transcription attenuation protein MtrB; Provisional; Region: PRK13251
1116391008525	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1116391008526	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1116391008527	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391008528	S-adenosylmethionine binding site [chemical binding]; other site
1116391008529	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1116391008530	UbiA prenyltransferase family; Region: UbiA; pfam01040
1116391008531	aromatic acid decarboxylase; Validated; Region: PRK05920
1116391008532	Flavoprotein; Region: Flavoprotein; pfam02441
1116391008533	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1116391008534	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1116391008535	substrate binding pocket [chemical binding]; other site
1116391008536	chain length determination region; other site
1116391008537	substrate-Mg2+ binding site; other site
1116391008538	catalytic residues [active]
1116391008539	aspartate-rich region 1; other site
1116391008540	active site lid residues [active]
1116391008541	aspartate-rich region 2; other site
1116391008542	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1116391008543	active site
1116391008544	multimer interface [polypeptide binding]; other site
1116391008545	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1116391008546	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1116391008547	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391008548	S-adenosylmethionine binding site [chemical binding]; other site
1116391008549	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1116391008550	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1116391008551	Tetramer interface [polypeptide binding]; other site
1116391008552	active site
1116391008553	FMN-binding site [chemical binding]; other site
1116391008554	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1116391008555	active site
1116391008556	dimer interface [polypeptide binding]; other site
1116391008557	metal binding site [ion binding]; metal-binding site
1116391008558	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1116391008559	homotrimer interaction site [polypeptide binding]; other site
1116391008560	active site
1116391008561	anthranilate synthase component I; Provisional; Region: PRK13569
1116391008562	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1116391008563	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1116391008564	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1116391008565	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1116391008566	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1116391008567	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1116391008568	active site
1116391008569	ribulose/triose binding site [chemical binding]; other site
1116391008570	phosphate binding site [ion binding]; other site
1116391008571	substrate (anthranilate) binding pocket [chemical binding]; other site
1116391008572	product (indole) binding pocket [chemical binding]; other site
1116391008573	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1116391008574	active site
1116391008575	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1116391008576	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1116391008577	substrate binding site [chemical binding]; other site
1116391008578	active site
1116391008579	catalytic residues [active]
1116391008580	heterodimer interface [polypeptide binding]; other site
1116391008581	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1116391008582	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391008583	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391008584	homodimer interface [polypeptide binding]; other site
1116391008585	catalytic residue [active]
1116391008586	prephenate dehydrogenase; Validated; Region: PRK06545
1116391008587	prephenate dehydrogenase; Validated; Region: PRK08507
1116391008588	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1116391008589	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1116391008590	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391008591	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391008592	DNA binding residues [nucleotide binding]
1116391008593	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
1116391008594	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1116391008595	catalytic core [active]
1116391008596	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1116391008597	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1116391008598	trimer interface [polypeptide binding]; other site
1116391008599	putative metal binding site [ion binding]; other site
1116391008600	IDEAL domain; Region: IDEAL; pfam08858
1116391008601	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
1116391008602	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1116391008603	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1116391008604	iron-sulfur cluster [ion binding]; other site
1116391008605	[2Fe-2S] cluster binding site [ion binding]; other site
1116391008606	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1116391008607	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1116391008608	interchain domain interface [polypeptide binding]; other site
1116391008609	intrachain domain interface; other site
1116391008610	heme bH binding site [chemical binding]; other site
1116391008611	Qi binding site; other site
1116391008612	heme bL binding site [chemical binding]; other site
1116391008613	Qo binding site; other site
1116391008614	intrachain domain interface; other site
1116391008615	Qi binding site; other site
1116391008616	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1116391008617	interchain domain interface [polypeptide binding]; other site
1116391008618	Qo binding site; other site
1116391008619	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1116391008620	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1116391008621	Protein of unknown function (DUF1405); Region: DUF1405; cl01798
1116391008622	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800
1116391008623	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391008624	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391008625	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391008626	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391008627	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1116391008628	homodimer interface [polypeptide binding]; other site
1116391008629	metal binding site [ion binding]; metal-binding site
1116391008630	TPR repeat; Region: TPR_11; pfam13414
1116391008631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391008632	TPR motif; other site
1116391008633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1116391008634	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1116391008635	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1116391008636	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1116391008637	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1116391008638	active site
1116391008639	dimer interfaces [polypeptide binding]; other site
1116391008640	catalytic residues [active]
1116391008641	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1116391008642	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1116391008643	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1116391008644	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1116391008645	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1116391008646	active site
1116391008647	NTP binding site [chemical binding]; other site
1116391008648	metal binding triad [ion binding]; metal-binding site
1116391008649	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1116391008650	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1116391008651	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1116391008652	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1116391008653	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1116391008654	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1116391008655	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1116391008656	active site
1116391008657	oligomerization interface [polypeptide binding]; other site
1116391008658	metal binding site [ion binding]; metal-binding site
1116391008659	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1116391008660	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1116391008661	active site
1116391008662	ATP-binding site [chemical binding]; other site
1116391008663	pantoate-binding site; other site
1116391008664	HXXH motif; other site
1116391008665	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1116391008666	tetramerization interface [polypeptide binding]; other site
1116391008667	active site
1116391008668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391008669	binding surface
1116391008670	TPR repeat; Region: TPR_11; pfam13414
1116391008671	TPR motif; other site
1116391008672	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1116391008673	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1116391008674	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1116391008675	active site
1116391008676	catalytic site [active]
1116391008677	substrate binding site [chemical binding]; other site
1116391008678	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391008679	ATP binding site [chemical binding]; other site
1116391008680	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1116391008681	putative Mg++ binding site [ion binding]; other site
1116391008682	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1116391008683	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1116391008684	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1116391008685	CoA binding domain; Region: CoA_binding; pfam02629
1116391008686	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1116391008687	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1116391008688	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
1116391008689	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1116391008690	active site
1116391008691	putative substrate binding pocket [chemical binding]; other site
1116391008692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1116391008693	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1116391008694	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391008695	Walker A motif; other site
1116391008696	ATP binding site [chemical binding]; other site
1116391008697	Walker B motif; other site
1116391008698	arginine finger; other site
1116391008699	Peptidase family M41; Region: Peptidase_M41; pfam01434
1116391008700	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391008701	AMIN domain; Region: AMIN; pfam11741
1116391008702	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1116391008703	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1116391008704	active site
1116391008705	metal binding site [ion binding]; metal-binding site
1116391008706	Sporulation and spore germination; Region: Germane; cl11253
1116391008707	S-layer homology domain; Region: SLH; pfam00395
1116391008708	S-layer homology domain; Region: SLH; pfam00395
1116391008709	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1116391008710	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1116391008711	minor groove reading motif; other site
1116391008712	helix-hairpin-helix signature motif; other site
1116391008713	substrate binding pocket [chemical binding]; other site
1116391008714	active site
1116391008715	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1116391008716	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
1116391008717	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1116391008718	Dynamin family; Region: Dynamin_N; pfam00350
1116391008719	G1 box; other site
1116391008720	GTP/Mg2+ binding site [chemical binding]; other site
1116391008721	G2 box; other site
1116391008722	Switch I region; other site
1116391008723	G3 box; other site
1116391008724	Switch II region; other site
1116391008725	G4 box; other site
1116391008726	G5 box; other site
1116391008727	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1116391008728	Dynamin family; Region: Dynamin_N; pfam00350
1116391008729	G1 box; other site
1116391008730	GTP/Mg2+ binding site [chemical binding]; other site
1116391008731	G2 box; other site
1116391008732	Switch I region; other site
1116391008733	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
1116391008734	G3 box; other site
1116391008735	Switch II region; other site
1116391008736	GTP/Mg2+ binding site [chemical binding]; other site
1116391008737	G4 box; other site
1116391008738	G5 box; other site
1116391008739	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391008740	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391008741	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391008742	Walker A/P-loop; other site
1116391008743	ATP binding site [chemical binding]; other site
1116391008744	Q-loop/lid; other site
1116391008745	ABC transporter signature motif; other site
1116391008746	Walker B; other site
1116391008747	D-loop; other site
1116391008748	H-loop/switch region; other site
1116391008749	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391008750	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391008751	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391008752	Walker A/P-loop; other site
1116391008753	ATP binding site [chemical binding]; other site
1116391008754	Q-loop/lid; other site
1116391008755	ABC transporter signature motif; other site
1116391008756	Walker B; other site
1116391008757	D-loop; other site
1116391008758	H-loop/switch region; other site
1116391008759	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391008760	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391008761	G5 domain; Region: G5; pfam07501
1116391008762	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391008763	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1116391008764	active site
1116391008765	catalytic triad [active]
1116391008766	oxyanion hole [active]
1116391008767	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391008768	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1116391008769	Walker A/P-loop; other site
1116391008770	ATP binding site [chemical binding]; other site
1116391008771	Q-loop/lid; other site
1116391008772	ABC transporter signature motif; other site
1116391008773	Walker B; other site
1116391008774	D-loop; other site
1116391008775	H-loop/switch region; other site
1116391008776	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1116391008777	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1116391008778	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1116391008779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391008780	Mg2+ binding site [ion binding]; other site
1116391008781	G-X-G motif; other site
1116391008782	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1116391008783	anchoring element; other site
1116391008784	dimer interface [polypeptide binding]; other site
1116391008785	ATP binding site [chemical binding]; other site
1116391008786	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1116391008787	active site
1116391008788	metal binding site [ion binding]; metal-binding site
1116391008789	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1116391008790	DNA gyrase subunit A; Validated; Region: PRK05560
1116391008791	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1116391008792	CAP-like domain; other site
1116391008793	active site
1116391008794	primary dimer interface [polypeptide binding]; other site
1116391008795	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391008796	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391008797	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391008798	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1116391008799	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1116391008800	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1116391008801	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1116391008802	active site
1116391008803	S-adenosylmethionine binding site [chemical binding]; other site
1116391008804	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1116391008805	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1116391008806	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1116391008807	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391008808	catalytic residue [active]
1116391008809	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391008810	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1116391008811	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
1116391008812	glycogen branching enzyme; Provisional; Region: PRK12313
1116391008813	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1116391008814	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1116391008815	active site
1116391008816	catalytic site [active]
1116391008817	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1116391008818	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1116391008819	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1116391008820	ligand binding site; other site
1116391008821	oligomer interface; other site
1116391008822	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1116391008823	dimer interface [polypeptide binding]; other site
1116391008824	N-terminal domain interface [polypeptide binding]; other site
1116391008825	sulfate 1 binding site; other site
1116391008826	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1116391008827	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1116391008828	ligand binding site; other site
1116391008829	oligomer interface; other site
1116391008830	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1116391008831	dimer interface [polypeptide binding]; other site
1116391008832	N-terminal domain interface [polypeptide binding]; other site
1116391008833	sulfate 1 binding site; other site
1116391008834	glycogen synthase; Provisional; Region: glgA; PRK00654
1116391008835	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1116391008836	ADP-binding pocket [chemical binding]; other site
1116391008837	homodimer interface [polypeptide binding]; other site
1116391008838	GAF domain; Region: GAF; pfam01590
1116391008839	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1116391008840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391008841	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391008842	dimer interface [polypeptide binding]; other site
1116391008843	phosphorylation site [posttranslational modification]
1116391008844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391008845	ATP binding site [chemical binding]; other site
1116391008846	Mg2+ binding site [ion binding]; other site
1116391008847	G-X-G motif; other site
1116391008848	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1116391008849	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1116391008850	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1116391008851	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
1116391008852	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1116391008853	active site
1116391008854	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
1116391008855	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1116391008856	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391008857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391008858	active site
1116391008859	phosphorylation site [posttranslational modification]
1116391008860	intermolecular recognition site; other site
1116391008861	dimerization interface [polypeptide binding]; other site
1116391008862	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391008863	DNA binding site [nucleotide binding]
1116391008864	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1116391008865	active site clefts [active]
1116391008866	zinc binding site [ion binding]; other site
1116391008867	dimer interface [polypeptide binding]; other site
1116391008868	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1116391008869	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1116391008870	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1116391008871	active site
1116391008872	Zn binding site [ion binding]; other site
1116391008873	Spore germination protein; Region: Spore_permease; cl17796
1116391008874	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391008875	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391008876	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1116391008877	NMT1-like family; Region: NMT1_2; pfam13379
1116391008878	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391008879	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391008880	Walker A/P-loop; other site
1116391008881	ATP binding site [chemical binding]; other site
1116391008882	Q-loop/lid; other site
1116391008883	ABC transporter signature motif; other site
1116391008884	Walker B; other site
1116391008885	D-loop; other site
1116391008886	H-loop/switch region; other site
1116391008887	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391008888	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391008889	dimer interface [polypeptide binding]; other site
1116391008890	conserved gate region; other site
1116391008891	putative PBP binding loops; other site
1116391008892	ABC-ATPase subunit interface; other site
1116391008893	Predicted membrane protein [Function unknown]; Region: COG4129
1116391008894	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1116391008895	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1116391008896	Outer spore coat protein E (CotE); Region: CotE; pfam10628
1116391008897	Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395
1116391008898	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1116391008899	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1116391008900	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1116391008901	protein binding site [polypeptide binding]; other site
1116391008902	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1116391008903	Catalytic dyad [active]
1116391008904	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391008905	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
1116391008906	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391008907	ATP binding site [chemical binding]; other site
1116391008908	Mg2+ binding site [ion binding]; other site
1116391008909	G-X-G motif; other site
1116391008910	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1116391008911	ATP binding site [chemical binding]; other site
1116391008912	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1116391008913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1116391008914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391008915	S-adenosylmethionine binding site [chemical binding]; other site
1116391008916	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1116391008917	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1116391008918	bacterial Hfq-like; Region: Hfq; cd01716
1116391008919	hexamer interface [polypeptide binding]; other site
1116391008920	Sm1 motif; other site
1116391008921	RNA binding site [nucleotide binding]; other site
1116391008922	Sm2 motif; other site
1116391008923	Transglycosylase; Region: Transgly; pfam00912
1116391008924	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1116391008925	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391008926	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1116391008927	active site
1116391008928	Esterase/lipase [General function prediction only]; Region: COG1647
1116391008929	PGAP1-like protein; Region: PGAP1; pfam07819
1116391008930	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1116391008931	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391008932	active site
1116391008933	metal binding site [ion binding]; metal-binding site
1116391008934	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1116391008935	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1116391008936	putative active site [active]
1116391008937	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1116391008938	short chain dehydrogenase; Provisional; Region: PRK06701
1116391008939	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1116391008940	NAD binding site [chemical binding]; other site
1116391008941	metal binding site [ion binding]; metal-binding site
1116391008942	active site
1116391008943	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1116391008944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391008945	motif II; other site
1116391008946	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1116391008947	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391008948	Walker A motif; other site
1116391008949	ATP binding site [chemical binding]; other site
1116391008950	Walker B motif; other site
1116391008951	arginine finger; other site
1116391008952	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1116391008953	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1116391008954	HflX GTPase family; Region: HflX; cd01878
1116391008955	G1 box; other site
1116391008956	GTP/Mg2+ binding site [chemical binding]; other site
1116391008957	Switch I region; other site
1116391008958	G2 box; other site
1116391008959	G3 box; other site
1116391008960	Switch II region; other site
1116391008961	G4 box; other site
1116391008962	G5 box; other site
1116391008963	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1116391008964	Aluminium resistance protein; Region: Alum_res; pfam06838
1116391008965	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1116391008966	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391008967	DNA binding residues [nucleotide binding]
1116391008968	putative dimer interface [polypeptide binding]; other site
1116391008969	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1116391008970	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1116391008971	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1116391008972	LexA repressor; Validated; Region: PRK00215
1116391008973	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391008974	putative DNA binding site [nucleotide binding]; other site
1116391008975	putative Zn2+ binding site [ion binding]; other site
1116391008976	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1116391008977	Catalytic site [active]
1116391008978	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391008979	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
1116391008980	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391008981	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391008982	active site
1116391008983	catalytic tetrad [active]
1116391008984	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1116391008985	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391008986	motif II; other site
1116391008987	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1116391008988	Cupin domain; Region: Cupin_2; cl17218
1116391008989	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1116391008990	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1116391008991	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1116391008992	substrate binding pocket [chemical binding]; other site
1116391008993	dimer interface [polypeptide binding]; other site
1116391008994	inhibitor binding site; inhibition site
1116391008995	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1116391008996	B12 binding site [chemical binding]; other site
1116391008997	cobalt ligand [ion binding]; other site
1116391008998	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1116391008999	ribonuclease Z; Region: RNase_Z; TIGR02651
1116391009000	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
1116391009001	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1116391009002	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1116391009003	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1116391009004	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1116391009005	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1116391009006	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1116391009007	putative acyl-acceptor binding pocket; other site
1116391009008	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1116391009009	phytoene desaturase; Region: crtI_fam; TIGR02734
1116391009010	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1116391009011	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1116391009012	DXD motif; other site
1116391009013	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1116391009014	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
1116391009015	putative acyl-acceptor binding pocket; other site
1116391009016	Protein of unknown function (DUF422); Region: DUF422; cl00991
1116391009017	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1116391009018	active site lid residues [active]
1116391009019	substrate binding pocket [chemical binding]; other site
1116391009020	catalytic residues [active]
1116391009021	substrate-Mg2+ binding site; other site
1116391009022	aspartate-rich region 1; other site
1116391009023	aspartate-rich region 2; other site
1116391009024	phytoene desaturase; Region: crtI_fam; TIGR02734
1116391009025	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391009026	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1116391009027	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391009028	phytoene desaturase; Region: crtI_fam; TIGR02734
1116391009029	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1116391009030	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391009031	ATP binding site [chemical binding]; other site
1116391009032	putative Mg++ binding site [ion binding]; other site
1116391009033	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391009034	nucleotide binding region [chemical binding]; other site
1116391009035	ATP-binding site [chemical binding]; other site
1116391009036	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1116391009037	RNase_H superfamily; Region: RNase_H_2; pfam13482
1116391009038	active site
1116391009039	substrate binding site [chemical binding]; other site
1116391009040	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1116391009041	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1116391009042	putative DNA binding site [nucleotide binding]; other site
1116391009043	catalytic residue [active]
1116391009044	putative H2TH interface [polypeptide binding]; other site
1116391009045	putative catalytic residues [active]
1116391009046	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1116391009047	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1116391009048	AP endonuclease family 2; Region: AP2Ec; smart00518
1116391009049	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1116391009050	AP (apurinic/apyrimidinic) site pocket; other site
1116391009051	DNA interaction; other site
1116391009052	Metal-binding active site; metal-binding site
1116391009053	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1116391009054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391009055	Walker A/P-loop; other site
1116391009056	ATP binding site [chemical binding]; other site
1116391009057	Q-loop/lid; other site
1116391009058	ABC transporter signature motif; other site
1116391009059	Walker B; other site
1116391009060	D-loop; other site
1116391009061	H-loop/switch region; other site
1116391009062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009063	S-adenosylmethionine binding site [chemical binding]; other site
1116391009064	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391009065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009066	S-adenosylmethionine binding site [chemical binding]; other site
1116391009067	AAA domain; Region: AAA_31; pfam13614
1116391009068	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1116391009069	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1116391009070	Walker A motif; other site
1116391009071	hexamer interface [polypeptide binding]; other site
1116391009072	ATP binding site [chemical binding]; other site
1116391009073	Walker B motif; other site
1116391009074	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1116391009075	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1116391009076	TadE-like protein; Region: TadE; pfam07811
1116391009077	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1116391009078	phosphopeptide binding site; other site
1116391009079	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1116391009080	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1116391009081	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1116391009082	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1116391009083	metal binding site [ion binding]; metal-binding site
1116391009084	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1116391009085	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391009086	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391009087	ABC transporter; Region: ABC_tran_2; pfam12848
1116391009088	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391009089	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1116391009090	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391009091	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391009092	ABC transporter; Region: ABC_tran_2; pfam12848
1116391009093	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391009094	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391009095	catalytic residues [active]
1116391009096	Kinase associated protein B; Region: KapB; pfam08810
1116391009097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391009098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391009099	ATP binding site [chemical binding]; other site
1116391009100	Mg2+ binding site [ion binding]; other site
1116391009101	G-X-G motif; other site
1116391009102	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391009103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391009104	active site
1116391009105	phosphorylation site [posttranslational modification]
1116391009106	intermolecular recognition site; other site
1116391009107	dimerization interface [polypeptide binding]; other site
1116391009108	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391009109	DNA binding residues [nucleotide binding]
1116391009110	dimerization interface [polypeptide binding]; other site
1116391009111	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391009112	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391009113	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391009114	Predicted membrane protein [Function unknown]; Region: COG2860
1116391009115	UPF0126 domain; Region: UPF0126; pfam03458
1116391009116	UPF0126 domain; Region: UPF0126; pfam03458
1116391009117	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1116391009118	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1116391009119	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391009120	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391009121	active site
1116391009122	phosphorylation site [posttranslational modification]
1116391009123	intermolecular recognition site; other site
1116391009124	dimerization interface [polypeptide binding]; other site
1116391009125	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391009126	DNA binding site [nucleotide binding]
1116391009127	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391009128	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391009129	dimerization interface [polypeptide binding]; other site
1116391009130	putative DNA binding site [nucleotide binding]; other site
1116391009131	putative Zn2+ binding site [ion binding]; other site
1116391009132	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1116391009133	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1116391009134	ATP-grasp domain; Region: ATP-grasp; pfam02222
1116391009135	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1116391009136	Predicted membrane protein [Function unknown]; Region: COG4682
1116391009137	yiaA/B two helix domain; Region: YiaAB; pfam05360
1116391009138	yiaA/B two helix domain; Region: YiaAB; pfam05360
1116391009139	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
1116391009140	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1116391009141	active site
1116391009142	metal binding site [ion binding]; metal-binding site
1116391009143	homotetramer interface [polypeptide binding]; other site
1116391009144	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
1116391009145	S-formylglutathione hydrolase; Region: PLN02442
1116391009146	Putative esterase; Region: Esterase; pfam00756
1116391009147	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1116391009148	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1116391009149	substrate binding site [chemical binding]; other site
1116391009150	Predicted ATPase [General function prediction only]; Region: COG3899
1116391009151	AAA ATPase domain; Region: AAA_16; pfam13191
1116391009152	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1116391009153	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1116391009154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391009155	TIGR01777 family protein; Region: yfcH
1116391009156	NAD(P) binding site [chemical binding]; other site
1116391009157	active site
1116391009158	DNA topoisomerase III; Provisional; Region: PRK07726
1116391009159	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1116391009160	active site
1116391009161	putative interdomain interaction site [polypeptide binding]; other site
1116391009162	putative metal-binding site [ion binding]; other site
1116391009163	putative nucleotide binding site [chemical binding]; other site
1116391009164	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1116391009165	domain I; other site
1116391009166	DNA binding groove [nucleotide binding]
1116391009167	phosphate binding site [ion binding]; other site
1116391009168	domain II; other site
1116391009169	domain III; other site
1116391009170	nucleotide binding site [chemical binding]; other site
1116391009171	catalytic site [active]
1116391009172	domain IV; other site
1116391009173	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1116391009174	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391009175	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391009176	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009177	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391009178	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391009179	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391009180	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391009181	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391009182	active site
1116391009183	catalytic tetrad [active]
1116391009184	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391009185	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391009186	active site
1116391009187	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391009188	HTH domain; Region: HTH_11; pfam08279
1116391009189	WYL domain; Region: WYL; pfam13280
1116391009190	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1116391009191	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
1116391009192	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391009193	putative NAD(P) binding site [chemical binding]; other site
1116391009194	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391009195	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391009196	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391009197	dimerization interface [polypeptide binding]; other site
1116391009198	putative DNA binding site [nucleotide binding]; other site
1116391009199	putative Zn2+ binding site [ion binding]; other site
1116391009200	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1116391009201	hydrophobic ligand binding site; other site
1116391009202	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391009203	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009204	S-adenosylmethionine binding site [chemical binding]; other site
1116391009205	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1116391009206	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1116391009207	putative active site [active]
1116391009208	catalytic triad [active]
1116391009209	putative dimer interface [polypeptide binding]; other site
1116391009210	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391009211	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1116391009212	E-class dimer interface [polypeptide binding]; other site
1116391009213	P-class dimer interface [polypeptide binding]; other site
1116391009214	active site
1116391009215	Cu2+ binding site [ion binding]; other site
1116391009216	Zn2+ binding site [ion binding]; other site
1116391009217	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391009218	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391009219	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391009220	dimerization interface [polypeptide binding]; other site
1116391009221	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1116391009222	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1116391009223	GDP-binding site [chemical binding]; other site
1116391009224	ACT binding site; other site
1116391009225	IMP binding site; other site
1116391009226	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
1116391009227	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
1116391009228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391009229	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391009230	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391009231	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
1116391009232	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1116391009233	metal ion-dependent adhesion site (MIDAS); other site
1116391009234	regulatory ATPase RavA; Provisional; Region: PRK13531
1116391009235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391009236	Walker A motif; other site
1116391009237	ATP binding site [chemical binding]; other site
1116391009238	Walker B motif; other site
1116391009239	arginine finger; other site
1116391009240	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1116391009241	catalytic residues [active]
1116391009242	dimer interface [polypeptide binding]; other site
1116391009243	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1116391009244	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1116391009245	Ligand Binding Site [chemical binding]; other site
1116391009246	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1116391009247	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1116391009248	dimerization interface [polypeptide binding]; other site
1116391009249	ligand binding site [chemical binding]; other site
1116391009250	NADP binding site [chemical binding]; other site
1116391009251	catalytic site [active]
1116391009252	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391009253	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391009254	Walker A/P-loop; other site
1116391009255	ATP binding site [chemical binding]; other site
1116391009256	Q-loop/lid; other site
1116391009257	ABC transporter signature motif; other site
1116391009258	Walker B; other site
1116391009259	D-loop; other site
1116391009260	H-loop/switch region; other site
1116391009261	FtsX-like permease family; Region: FtsX; pfam02687
1116391009262	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391009263	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391009264	acyl-activating enzyme (AAE) consensus motif; other site
1116391009265	AMP binding site [chemical binding]; other site
1116391009266	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391009267	Condensation domain; Region: Condensation; pfam00668
1116391009268	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391009269	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391009270	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391009271	acyl-activating enzyme (AAE) consensus motif; other site
1116391009272	AMP binding site [chemical binding]; other site
1116391009273	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391009274	Condensation domain; Region: Condensation; pfam00668
1116391009275	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391009276	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391009277	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391009278	acyl-activating enzyme (AAE) consensus motif; other site
1116391009279	AMP binding site [chemical binding]; other site
1116391009280	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391009281	Condensation domain; Region: Condensation; pfam00668
1116391009282	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391009283	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391009284	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391009285	acyl-activating enzyme (AAE) consensus motif; other site
1116391009286	AMP binding site [chemical binding]; other site
1116391009287	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391009288	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1116391009289	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391009290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391009291	active site
1116391009292	phosphorylation site [posttranslational modification]
1116391009293	intermolecular recognition site; other site
1116391009294	dimerization interface [polypeptide binding]; other site
1116391009295	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391009296	DNA binding site [nucleotide binding]
1116391009297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391009298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391009299	ATP binding site [chemical binding]; other site
1116391009300	Mg2+ binding site [ion binding]; other site
1116391009301	G-X-G motif; other site
1116391009302	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391009303	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391009304	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391009305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391009306	non-specific DNA binding site [nucleotide binding]; other site
1116391009307	salt bridge; other site
1116391009308	sequence-specific DNA binding site [nucleotide binding]; other site
1116391009309	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1116391009310	Class II fumarases; Region: Fumarase_classII; cd01362
1116391009311	active site
1116391009312	tetramer interface [polypeptide binding]; other site
1116391009313	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1116391009314	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1116391009315	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1116391009316	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1116391009317	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1116391009318	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1116391009319	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1116391009320	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1116391009321	ATP binding site [chemical binding]; other site
1116391009322	Walker A motif; other site
1116391009323	hexamer interface [polypeptide binding]; other site
1116391009324	Walker B motif; other site
1116391009325	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1116391009326	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1116391009327	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1116391009328	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391009329	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391009330	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391009331	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391009332	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391009333	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391009334	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1116391009335	active site
1116391009336	putative interdomain interaction site [polypeptide binding]; other site
1116391009337	putative metal-binding site [ion binding]; other site
1116391009338	putative nucleotide binding site [chemical binding]; other site
1116391009339	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1116391009340	domain I; other site
1116391009341	DNA binding groove [nucleotide binding]
1116391009342	phosphate binding site [ion binding]; other site
1116391009343	domain II; other site
1116391009344	domain III; other site
1116391009345	nucleotide binding site [chemical binding]; other site
1116391009346	catalytic site [active]
1116391009347	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1116391009348	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1116391009349	HAMP domain; Region: HAMP; pfam00672
1116391009350	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391009351	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391009352	dimer interface [polypeptide binding]; other site
1116391009353	putative CheW interface [polypeptide binding]; other site
1116391009354	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1116391009355	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1116391009356	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1116391009357	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1116391009358	metal binding site 2 [ion binding]; metal-binding site
1116391009359	putative DNA binding helix; other site
1116391009360	metal binding site 1 [ion binding]; metal-binding site
1116391009361	dimer interface [polypeptide binding]; other site
1116391009362	structural Zn2+ binding site [ion binding]; other site
1116391009363	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391009364	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1116391009365	substrate binding pocket [chemical binding]; other site
1116391009366	membrane-bound complex binding site; other site
1116391009367	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1116391009368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009369	dimer interface [polypeptide binding]; other site
1116391009370	conserved gate region; other site
1116391009371	putative PBP binding loops; other site
1116391009372	ABC-ATPase subunit interface; other site
1116391009373	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009374	dimer interface [polypeptide binding]; other site
1116391009375	conserved gate region; other site
1116391009376	putative PBP binding loops; other site
1116391009377	ABC-ATPase subunit interface; other site
1116391009378	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1116391009379	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1116391009380	Walker A/P-loop; other site
1116391009381	ATP binding site [chemical binding]; other site
1116391009382	Q-loop/lid; other site
1116391009383	ABC transporter signature motif; other site
1116391009384	Walker B; other site
1116391009385	D-loop; other site
1116391009386	H-loop/switch region; other site
1116391009387	TOBE domain; Region: TOBE_2; pfam08402
1116391009388	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1116391009389	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391009390	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
1116391009391	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
1116391009392	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391009393	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1116391009394	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391009395	substrate binding pocket [chemical binding]; other site
1116391009396	membrane-bound complex binding site; other site
1116391009397	hinge residues; other site
1116391009398	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1116391009399	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1116391009400	active site
1116391009401	dimer interface [polypeptide binding]; other site
1116391009402	non-prolyl cis peptide bond; other site
1116391009403	insertion regions; other site
1116391009404	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391009405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009406	dimer interface [polypeptide binding]; other site
1116391009407	conserved gate region; other site
1116391009408	putative PBP binding loops; other site
1116391009409	ABC-ATPase subunit interface; other site
1116391009410	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1116391009411	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391009412	Walker A/P-loop; other site
1116391009413	ATP binding site [chemical binding]; other site
1116391009414	Q-loop/lid; other site
1116391009415	ABC transporter signature motif; other site
1116391009416	Walker B; other site
1116391009417	D-loop; other site
1116391009418	H-loop/switch region; other site
1116391009419	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391009420	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391009421	Walker A/P-loop; other site
1116391009422	ATP binding site [chemical binding]; other site
1116391009423	Q-loop/lid; other site
1116391009424	ABC transporter signature motif; other site
1116391009425	Walker B; other site
1116391009426	D-loop; other site
1116391009427	H-loop/switch region; other site
1116391009428	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391009429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009430	dimer interface [polypeptide binding]; other site
1116391009431	conserved gate region; other site
1116391009432	putative PBP binding loops; other site
1116391009433	ABC-ATPase subunit interface; other site
1116391009434	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1116391009435	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391009436	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391009437	active site
1116391009438	catalytic tetrad [active]
1116391009439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391009440	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391009441	putative substrate translocation pore; other site
1116391009442	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391009443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391009444	substrate binding pocket [chemical binding]; other site
1116391009445	membrane-bound complex binding site; other site
1116391009446	hinge residues; other site
1116391009447	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391009448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009449	dimer interface [polypeptide binding]; other site
1116391009450	conserved gate region; other site
1116391009451	ABC-ATPase subunit interface; other site
1116391009452	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391009453	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391009454	Walker A/P-loop; other site
1116391009455	ATP binding site [chemical binding]; other site
1116391009456	Q-loop/lid; other site
1116391009457	ABC transporter signature motif; other site
1116391009458	Walker B; other site
1116391009459	D-loop; other site
1116391009460	H-loop/switch region; other site
1116391009461	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391009462	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1116391009463	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1116391009464	metal binding site [ion binding]; metal-binding site
1116391009465	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
1116391009466	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1116391009467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391009468	Walker A/P-loop; other site
1116391009469	ATP binding site [chemical binding]; other site
1116391009470	Q-loop/lid; other site
1116391009471	ABC transporter signature motif; other site
1116391009472	Walker B; other site
1116391009473	D-loop; other site
1116391009474	H-loop/switch region; other site
1116391009475	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1116391009476	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1116391009477	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391009478	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1116391009479	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1116391009480	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391009481	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391009482	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391009483	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1116391009484	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1116391009485	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1116391009486	AAA domain; Region: AAA_18; pfam13238
1116391009487	ATP-binding site [chemical binding]; other site
1116391009488	Sugar specificity; other site
1116391009489	Pyrimidine base specificity; other site
1116391009490	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391009491	classical (c) SDRs; Region: SDR_c; cd05233
1116391009492	NAD(P) binding site [chemical binding]; other site
1116391009493	active site
1116391009494	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1116391009495	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1116391009496	Ca binding site [ion binding]; other site
1116391009497	active site
1116391009498	catalytic site [active]
1116391009499	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1116391009500	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1116391009501	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1116391009502	dimer interface [polypeptide binding]; other site
1116391009503	active site
1116391009504	metal binding site [ion binding]; metal-binding site
1116391009505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391009506	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391009507	putative substrate translocation pore; other site
1116391009508	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1116391009509	nucleotide binding site/active site [active]
1116391009510	HIT family signature motif; other site
1116391009511	catalytic residue [active]
1116391009512	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391009513	Coenzyme A binding pocket [chemical binding]; other site
1116391009514	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1116391009515	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1116391009516	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391009517	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1116391009518	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1116391009519	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1116391009520	active site
1116391009521	active site
1116391009522	catalytic residues [active]
1116391009523	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
1116391009524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1116391009525	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391009526	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009527	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1116391009528	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
1116391009529	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1116391009530	dimerization interface [polypeptide binding]; other site
1116391009531	mannose binding site [chemical binding]; other site
1116391009532	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1116391009533	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391009534	DNA-binding site [nucleotide binding]; DNA binding site
1116391009535	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1116391009536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391009537	D-galactonate transporter; Region: 2A0114; TIGR00893
1116391009538	putative substrate translocation pore; other site
1116391009539	transketolase; Reviewed; Region: PRK05899
1116391009540	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1116391009541	TPP-binding site [chemical binding]; other site
1116391009542	dimer interface [polypeptide binding]; other site
1116391009543	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1116391009544	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1116391009545	PYR/PP interface [polypeptide binding]; other site
1116391009546	dimer interface [polypeptide binding]; other site
1116391009547	TPP binding site [chemical binding]; other site
1116391009548	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391009549	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391009550	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391009551	NAD(P) binding site [chemical binding]; other site
1116391009552	active site
1116391009553	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1116391009554	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391009555	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391009556	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391009557	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391009558	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1116391009559	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1116391009560	Walker A/P-loop; other site
1116391009561	ATP binding site [chemical binding]; other site
1116391009562	Q-loop/lid; other site
1116391009563	ABC transporter signature motif; other site
1116391009564	Walker B; other site
1116391009565	D-loop; other site
1116391009566	H-loop/switch region; other site
1116391009567	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391009568	ABC-ATPase subunit  interface; other site
1116391009569	dimer interface [polypeptide binding]; other site
1116391009570	putative PBP binding regions; other site
1116391009571	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391009572	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391009573	ABC-ATPase subunit  interface; other site
1116391009574	dimer interface [polypeptide binding]; other site
1116391009575	putative PBP binding regions; other site
1116391009576	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1116391009577	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1116391009578	siderophore binding site; other site
1116391009579	Predicted membrane protein [Function unknown]; Region: COG2364
1116391009580	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391009581	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391009582	Coenzyme A binding pocket [chemical binding]; other site
1116391009583	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391009584	MarR family; Region: MarR; pfam01047
1116391009585	DoxX-like family; Region: DoxX_2; pfam13564
1116391009586	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391009587	dimerization interface [polypeptide binding]; other site
1116391009588	putative DNA binding site [nucleotide binding]; other site
1116391009589	putative Zn2+ binding site [ion binding]; other site
1116391009590	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1116391009591	putative hydrophobic ligand binding site [chemical binding]; other site
1116391009592	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1116391009593	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1116391009594	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1116391009595	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
1116391009596	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391009597	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1116391009598	DNA binding residues [nucleotide binding]
1116391009599	putative dimer interface [polypeptide binding]; other site
1116391009600	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1116391009601	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1116391009602	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391009603	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391009604	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1116391009605	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1116391009606	putative NAD(P) binding site [chemical binding]; other site
1116391009607	putative substrate binding site [chemical binding]; other site
1116391009608	catalytic Zn binding site [ion binding]; other site
1116391009609	structural Zn binding site [ion binding]; other site
1116391009610	dimer interface [polypeptide binding]; other site
1116391009611	Uncharacterized conserved protein [Function unknown]; Region: COG4925
1116391009612	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
1116391009613	Helix-turn-helix domain; Region: HTH_17; pfam12728
1116391009614	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391009615	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391009616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009617	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391009618	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391009619	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391009620	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
1116391009621	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391009622	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391009623	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009625	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1116391009626	classical (c) SDRs; Region: SDR_c; cd05233
1116391009627	NAD(P) binding site [chemical binding]; other site
1116391009628	active site
1116391009629	galactonate dehydratase; Provisional; Region: PRK14017
1116391009630	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1116391009631	putative active site pocket [active]
1116391009632	putative metal binding site [ion binding]; other site
1116391009633	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1116391009634	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391009635	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1116391009636	CAAX protease self-immunity; Region: Abi; pfam02517
1116391009637	serine/threonine transporter SstT; Provisional; Region: PRK13628
1116391009638	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1116391009639	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1116391009640	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1116391009641	dimer interface [polypeptide binding]; other site
1116391009642	FMN binding site [chemical binding]; other site
1116391009643	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391009644	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391009645	putative DNA binding site [nucleotide binding]; other site
1116391009646	putative Zn2+ binding site [ion binding]; other site
1116391009647	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1116391009648	catalytic core [active]
1116391009649	Phosphotransferase enzyme family; Region: APH; pfam01636
1116391009650	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1116391009651	active site
1116391009652	substrate binding site [chemical binding]; other site
1116391009653	ATP binding site [chemical binding]; other site
1116391009654	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1116391009655	DinB superfamily; Region: DinB_2; pfam12867
1116391009656	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
1116391009657	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
1116391009658	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1116391009659	RNAase interaction site [polypeptide binding]; other site
1116391009660	Helix-turn-helix domain; Region: HTH_17; pfam12728
1116391009661	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1116391009662	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1116391009663	putative oxidoreductase; Provisional; Region: PRK08275
1116391009664	L-aspartate oxidase; Provisional; Region: PRK06175
1116391009665	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1116391009666	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1116391009667	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1116391009668	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1116391009669	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391009670	membrane-bound complex binding site; other site
1116391009671	hinge residues; other site
1116391009672	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
1116391009673	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391009674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009675	dimer interface [polypeptide binding]; other site
1116391009676	conserved gate region; other site
1116391009677	putative PBP binding loops; other site
1116391009678	ABC-ATPase subunit interface; other site
1116391009679	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391009680	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391009681	active site
1116391009682	metal binding site [ion binding]; metal-binding site
1116391009683	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1116391009684	dimer interface [polypeptide binding]; other site
1116391009685	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391009686	ligand binding site [chemical binding]; other site
1116391009687	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391009688	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009689	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1116391009690	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1116391009691	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1116391009692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009693	S-adenosylmethionine binding site [chemical binding]; other site
1116391009694	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391009695	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391009696	Coenzyme A binding pocket [chemical binding]; other site
1116391009697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009698	S-adenosylmethionine binding site [chemical binding]; other site
1116391009699	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391009700	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391009701	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391009702	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391009703	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391009704	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391009705	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1116391009706	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1116391009707	active site
1116391009708	PAS fold; Region: PAS_4; pfam08448
1116391009709	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391009710	putative active site [active]
1116391009711	heme pocket [chemical binding]; other site
1116391009712	PAS domain S-box; Region: sensory_box; TIGR00229
1116391009713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391009714	putative active site [active]
1116391009715	heme pocket [chemical binding]; other site
1116391009716	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391009717	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391009718	putative active site [active]
1116391009719	heme pocket [chemical binding]; other site
1116391009720	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391009721	dimer interface [polypeptide binding]; other site
1116391009722	phosphorylation site [posttranslational modification]
1116391009723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391009724	ATP binding site [chemical binding]; other site
1116391009725	Mg2+ binding site [ion binding]; other site
1116391009726	G-X-G motif; other site
1116391009727	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391009728	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391009729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009730	S-adenosylmethionine binding site [chemical binding]; other site
1116391009731	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391009732	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391009733	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009734	KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592
1116391009735	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1116391009736	putative active site [active]
1116391009737	putative catalytic site [active]
1116391009738	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391009739	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391009740	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391009741	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391009742	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391009743	Transposase; Region: HTH_Tnp_1; cl17663
1116391009744	HTH-like domain; Region: HTH_21; pfam13276
1116391009745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391009746	Integrase core domain; Region: rve; pfam00665
1116391009747	Integrase core domain; Region: rve_3; pfam13683
1116391009748	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
1116391009749	active site
1116391009750	catalytic triad [active]
1116391009751	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391009752	catalytic residues [active]
1116391009753	Protein of unknown function (DUF419); Region: DUF419; cl15265
1116391009754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1116391009755	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1116391009756	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
1116391009757	putative active site [active]
1116391009758	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391009759	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1116391009760	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1116391009761	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1116391009762	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1116391009763	metal-binding site
1116391009764	xanthine dehydrogenase C subunit; Region: pucC; TIGR03199
1116391009765	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1116391009766	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
1116391009767	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1116391009768	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391009769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391009770	active site
1116391009771	phosphorylation site [posttranslational modification]
1116391009772	intermolecular recognition site; other site
1116391009773	dimerization interface [polypeptide binding]; other site
1116391009774	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1116391009775	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391009776	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391009777	Walker A/P-loop; other site
1116391009778	ATP binding site [chemical binding]; other site
1116391009779	Q-loop/lid; other site
1116391009780	ABC transporter signature motif; other site
1116391009781	Walker B; other site
1116391009782	D-loop; other site
1116391009783	H-loop/switch region; other site
1116391009784	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1116391009785	FAD binding domain; Region: FAD_binding_4; pfam01565
1116391009786	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391009787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391009788	dimer interface [polypeptide binding]; other site
1116391009789	conserved gate region; other site
1116391009790	ABC-ATPase subunit interface; other site
1116391009791	cytosine deaminase; Provisional; Region: PRK09230
1116391009792	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1116391009793	active site
1116391009794	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1116391009795	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391009796	NMT1/THI5 like; Region: NMT1; pfam09084
1116391009797	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391009798	substrate binding pocket [chemical binding]; other site
1116391009799	hinge residues; other site
1116391009800	cytosine deaminase; Provisional; Region: PRK09230
1116391009801	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1116391009802	active site
1116391009803	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
1116391009804	Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648
1116391009805	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1116391009806	active site
1116391009807	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1116391009808	active site
1116391009809	homotetramer interface [polypeptide binding]; other site
1116391009810	allantoinase; Provisional; Region: PRK06189
1116391009811	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1116391009812	active site
1116391009813	allantoate amidohydrolase; Reviewed; Region: PRK09290
1116391009814	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1116391009815	active site
1116391009816	metal binding site [ion binding]; metal-binding site
1116391009817	dimer interface [polypeptide binding]; other site
1116391009818	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1116391009819	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391009820	catalytic residue [active]
1116391009821	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1116391009822	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1116391009823	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1116391009824	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391009825	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391009826	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1116391009827	NPCBM/NEW2 domain; Region: NPCBM; cl07060
1116391009828	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
1116391009829	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
1116391009830	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
1116391009831	4Fe-4S binding domain; Region: Fer4; cl02805
1116391009832	4Fe-4S binding domain; Region: Fer4; pfam00037
1116391009833	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
1116391009834	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1116391009835	dimer interface [polypeptide binding]; other site
1116391009836	PYR/PP interface [polypeptide binding]; other site
1116391009837	TPP binding site [chemical binding]; other site
1116391009838	substrate binding site [chemical binding]; other site
1116391009839	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
1116391009840	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1116391009841	TPP-binding site [chemical binding]; other site
1116391009842	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391009843	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391009844	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391009845	DoxX-like family; Region: DoxX_2; pfam13564
1116391009846	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391009847	Coenzyme A binding pocket [chemical binding]; other site
1116391009848	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391009849	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391009850	Coenzyme A binding pocket [chemical binding]; other site
1116391009851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009852	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391009853	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009854	short chain dehydrogenase; Provisional; Region: PRK06180
1116391009855	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1116391009856	NADP binding site [chemical binding]; other site
1116391009857	active site
1116391009858	steroid binding site; other site
1116391009859	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391009860	MarR family; Region: MarR_2; pfam12802
1116391009861	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1116391009862	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1116391009863	EamA-like transporter family; Region: EamA; pfam00892
1116391009864	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1116391009865	GAF domain; Region: GAF_2; pfam13185
1116391009866	EDD domain protein, DegV family; Region: DegV; TIGR00762
1116391009867	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1116391009868	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391009869	EamA-like transporter family; Region: EamA; pfam00892
1116391009870	EamA-like transporter family; Region: EamA; pfam00892
1116391009871	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1116391009872	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1116391009873	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391009874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391009875	active site
1116391009876	phosphorylation site [posttranslational modification]
1116391009877	intermolecular recognition site; other site
1116391009878	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391009879	DNA binding site [nucleotide binding]
1116391009880	peptide synthase; Provisional; Region: PRK12316
1116391009881	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391009882	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391009883	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1116391009884	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1116391009885	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1116391009886	putative active site [active]
1116391009887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391009888	NAD(P) binding site [chemical binding]; other site
1116391009889	active site
1116391009890	benzoate transport; Region: 2A0115; TIGR00895
1116391009891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391009892	putative substrate translocation pore; other site
1116391009893	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1116391009894	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1116391009895	NADP binding site [chemical binding]; other site
1116391009896	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1116391009897	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1116391009898	catalytic residues [active]
1116391009899	FlaG protein; Region: FlaG; pfam03646
1116391009900	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1116391009901	alanine racemase; Reviewed; Region: alr; PRK00053
1116391009902	active site
1116391009903	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1116391009904	dimer interface [polypeptide binding]; other site
1116391009905	substrate binding site [chemical binding]; other site
1116391009906	catalytic residues [active]
1116391009907	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1116391009908	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1116391009909	hexamer interface [polypeptide binding]; other site
1116391009910	ligand binding site [chemical binding]; other site
1116391009911	putative active site [active]
1116391009912	NAD(P) binding site [chemical binding]; other site
1116391009913	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1116391009914	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1116391009915	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1116391009916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391009917	S-adenosylmethionine binding site [chemical binding]; other site
1116391009918	N-acetyltransferase; Region: Acetyltransf_2; cl00949
1116391009919	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
1116391009920	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692
1116391009921	nudix motif; other site
1116391009922	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1116391009923	active site
1116391009924	catalytic residues [active]
1116391009925	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
1116391009926	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1116391009927	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391009928	Coenzyme A binding pocket [chemical binding]; other site
1116391009929	DNA polymerase III subunit epsilon; Validated; Region: PRK05601
1116391009930	beta-D-glucuronidase; Provisional; Region: PRK10150
1116391009931	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391009932	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391009933	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391009934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009935	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391009936	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009937	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1116391009938	putative active site [active]
1116391009939	putative metal binding site [ion binding]; other site
1116391009940	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
1116391009941	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391009942	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391009943	non-specific DNA binding site [nucleotide binding]; other site
1116391009944	salt bridge; other site
1116391009945	sequence-specific DNA binding site [nucleotide binding]; other site
1116391009946	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391009947	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391009948	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1116391009949	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1116391009950	Substrate binding site; other site
1116391009951	Cupin domain; Region: Cupin_2; cl17218
1116391009952	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1116391009953	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1116391009954	NADP-binding site; other site
1116391009955	homotetramer interface [polypeptide binding]; other site
1116391009956	substrate binding site [chemical binding]; other site
1116391009957	homodimer interface [polypeptide binding]; other site
1116391009958	active site
1116391009959	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1116391009960	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1116391009961	inhibitor-cofactor binding pocket; inhibition site
1116391009962	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391009963	catalytic residue [active]
1116391009964	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1116391009965	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1116391009966	putative trimer interface [polypeptide binding]; other site
1116391009967	putative CoA binding site [chemical binding]; other site
1116391009968	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
1116391009969	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391009970	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391009971	non-specific DNA binding site [nucleotide binding]; other site
1116391009972	salt bridge; other site
1116391009973	sequence-specific DNA binding site [nucleotide binding]; other site
1116391009974	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1116391009975	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1116391009976	siderophore binding site; other site
1116391009977	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391009978	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391009979	ABC-ATPase subunit  interface; other site
1116391009980	dimer interface [polypeptide binding]; other site
1116391009981	putative PBP binding regions; other site
1116391009982	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391009983	ABC-ATPase subunit  interface; other site
1116391009984	dimer interface [polypeptide binding]; other site
1116391009985	putative PBP binding regions; other site
1116391009986	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391009987	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391009988	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391009989	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
1116391009990	substrate binding site [chemical binding]; other site
1116391009991	active site
1116391009992	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1116391009993	dimer interface [polypeptide binding]; other site
1116391009994	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391009995	Cupin domain; Region: Cupin_2; pfam07883
1116391009996	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391009997	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391009998	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
1116391009999	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391010000	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391010001	protein binding site [polypeptide binding]; other site
1116391010002	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391010003	MarR family; Region: MarR; pfam01047
1116391010004	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1116391010005	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391010006	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1116391010007	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1116391010008	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1116391010009	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
1116391010010	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1116391010011	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1116391010012	generic binding surface I; other site
1116391010013	generic binding surface II; other site
1116391010014	HD domain; Region: HD; pfam01966
1116391010015	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1116391010016	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1116391010017	beta-galactosidase; Region: BGL; TIGR03356
1116391010018	hypothetical protein; Provisional; Region: PRK12378
1116391010019	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391010020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391010021	Coenzyme A binding pocket [chemical binding]; other site
1116391010022	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391010023	Zn2+ binding site [ion binding]; other site
1116391010024	Mg2+ binding site [ion binding]; other site
1116391010025	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391010026	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391010027	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391010028	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881
1116391010029	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1116391010030	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1116391010031	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391010032	nucleotide binding region [chemical binding]; other site
1116391010033	ATP-binding site [chemical binding]; other site
1116391010034	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1116391010035	dimer interface [polypeptide binding]; other site
1116391010036	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010037	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391010038	HTH-like domain; Region: HTH_21; pfam13276
1116391010039	Integrase core domain; Region: rve; pfam00665
1116391010040	Integrase core domain; Region: rve_2; pfam13333
1116391010041	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391010042	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391010043	Transposase; Region: HTH_Tnp_1; cl17663
1116391010044	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391010045	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1116391010046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391010047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391010048	DNA binding residues [nucleotide binding]
1116391010049	SnoaL-like domain; Region: SnoaL_2; pfam12680
1116391010050	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
1116391010051	putative hydrophobic ligand binding site [chemical binding]; other site
1116391010052	DoxX-like family; Region: DoxX_2; pfam13564
1116391010053	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1116391010054	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1116391010055	FMN binding site [chemical binding]; other site
1116391010056	active site
1116391010057	substrate binding site [chemical binding]; other site
1116391010058	catalytic residue [active]
1116391010059	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391010060	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391010061	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1116391010062	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
1116391010063	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391010064	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391010065	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1116391010066	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1116391010067	NADP binding site [chemical binding]; other site
1116391010068	RibD C-terminal domain; Region: RibD_C; cl17279
1116391010069	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1116391010070	Immunity protein Imm6; Region: Imm6; pfam14434
1116391010071	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1116391010072	active site
1116391010073	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1116391010074	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1116391010075	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391010076	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391010077	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391010078	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391010079	putative substrate translocation pore; other site
1116391010080	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391010081	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391010082	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1116391010083	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1116391010084	AAA domain; Region: AAA_18; pfam13238
1116391010085	active site
1116391010086	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391010087	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1116391010088	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391010089	active site
1116391010090	dimer interface [polypeptide binding]; other site
1116391010091	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
1116391010092	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391010093	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391010094	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391010095	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1116391010096	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1116391010097	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010098	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010099	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
1116391010100	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1116391010101	active site
1116391010102	amidase; Provisional; Region: PRK06828
1116391010103	Amidase; Region: Amidase; cl11426
1116391010104	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391010105	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391010106	Coenzyme A binding pocket [chemical binding]; other site
1116391010107	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391010108	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391010109	active site
1116391010110	catalytic tetrad [active]
1116391010111	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1116391010112	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1116391010113	putative substrate binding site [chemical binding]; other site
1116391010114	putative ATP binding site [chemical binding]; other site
1116391010115	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1116391010116	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1116391010117	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1116391010118	active site
1116391010119	DNA binding site [nucleotide binding]
1116391010120	Int/Topo IB signature motif; other site
1116391010121	peptide synthase; Validated; Region: PRK05691
1116391010122	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
1116391010123	dimer interface [polypeptide binding]; other site
1116391010124	Citrate synthase; Region: Citrate_synt; pfam00285
1116391010125	active site
1116391010126	citrylCoA binding site [chemical binding]; other site
1116391010127	oxalacetate/citrate binding site [chemical binding]; other site
1116391010128	coenzyme A binding site [chemical binding]; other site
1116391010129	catalytic triad [active]
1116391010130	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1116391010131	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391010132	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391010133	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391010134	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391010135	DNA binding site [nucleotide binding]
1116391010136	domain linker motif; other site
1116391010137	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391010138	dimerization interface [polypeptide binding]; other site
1116391010139	ligand binding site [chemical binding]; other site
1116391010140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010141	dimer interface [polypeptide binding]; other site
1116391010142	conserved gate region; other site
1116391010143	putative PBP binding loops; other site
1116391010144	ABC-ATPase subunit interface; other site
1116391010145	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010147	dimer interface [polypeptide binding]; other site
1116391010148	conserved gate region; other site
1116391010149	putative PBP binding loops; other site
1116391010150	ABC-ATPase subunit interface; other site
1116391010151	Cytochrome c; Region: Cytochrom_C; pfam00034
1116391010152	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1116391010153	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391010154	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010155	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1116391010156	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391010157	substrate binding site [chemical binding]; other site
1116391010158	ATP binding site [chemical binding]; other site
1116391010159	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1116391010160	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1116391010161	dimerization interface [polypeptide binding]; other site
1116391010162	ligand binding site [chemical binding]; other site
1116391010163	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391010164	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1116391010165	TM-ABC transporter signature motif; other site
1116391010166	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1116391010167	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1116391010168	TM-ABC transporter signature motif; other site
1116391010169	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1116391010170	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1116391010171	Walker A/P-loop; other site
1116391010172	ATP binding site [chemical binding]; other site
1116391010173	Q-loop/lid; other site
1116391010174	ABC transporter signature motif; other site
1116391010175	Walker B; other site
1116391010176	D-loop; other site
1116391010177	H-loop/switch region; other site
1116391010178	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1116391010179	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1116391010180	Walker A/P-loop; other site
1116391010181	ATP binding site [chemical binding]; other site
1116391010182	Q-loop/lid; other site
1116391010183	ABC transporter signature motif; other site
1116391010184	Walker B; other site
1116391010185	D-loop; other site
1116391010186	H-loop/switch region; other site
1116391010187	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391010188	Spore germination protein; Region: Spore_permease; cl17796
1116391010189	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391010190	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391010191	Predicted membrane protein [Function unknown]; Region: COG2322
1116391010192	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391010193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391010194	S-adenosylmethionine binding site [chemical binding]; other site
1116391010195	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
1116391010196	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391010197	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391010198	DNA binding residues [nucleotide binding]
1116391010199	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1116391010200	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1116391010201	active site
1116391010202	oxyanion hole [active]
1116391010203	catalytic triad [active]
1116391010204	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
1116391010205	dimer interface [polypeptide binding]; other site
1116391010206	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010207	DinB superfamily; Region: DinB_2; pfam12867
1116391010208	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1116391010209	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1116391010210	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391010211	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1116391010212	DNA binding residues [nucleotide binding]
1116391010213	putative dimer interface [polypeptide binding]; other site
1116391010214	short chain dehydrogenase; Provisional; Region: PRK06500
1116391010215	classical (c) SDRs; Region: SDR_c; cd05233
1116391010216	NAD(P) binding site [chemical binding]; other site
1116391010217	active site
1116391010218	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391010219	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391010220	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391010221	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391010222	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391010223	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391010224	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391010225	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391010226	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
1116391010227	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391010228	sugar binding site [chemical binding]; other site
1116391010229	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391010230	sugar binding site [chemical binding]; other site
1116391010231	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
1116391010232	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1116391010233	beta-D-glucuronidase; Provisional; Region: PRK10150
1116391010234	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391010235	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391010236	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391010237	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391010238	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1116391010239	putative active site [active]
1116391010240	putative metal binding site [ion binding]; other site
1116391010241	BNR repeat-like domain; Region: BNR_2; pfam13088
1116391010242	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1116391010243	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391010244	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1116391010245	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391010246	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1116391010247	inhibitor binding site; inhibition site
1116391010248	active site
1116391010249	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1116391010250	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391010251	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391010252	putative sugar binding sites [chemical binding]; other site
1116391010253	Q-X-W motif; other site
1116391010254	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391010255	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1116391010256	putative sugar binding sites [chemical binding]; other site
1116391010257	Q-X-W motif; other site
1116391010258	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391010259	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1116391010260	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1116391010261	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1116391010262	ligand binding site [chemical binding]; other site
1116391010263	metal binding site [ion binding]; metal-binding site
1116391010264	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010265	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010266	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010268	dimer interface [polypeptide binding]; other site
1116391010269	conserved gate region; other site
1116391010270	ABC-ATPase subunit interface; other site
1116391010271	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010273	dimer interface [polypeptide binding]; other site
1116391010274	conserved gate region; other site
1116391010275	putative PBP binding loops; other site
1116391010276	ABC-ATPase subunit interface; other site
1116391010277	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010278	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010279	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391010280	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391010281	active site
1116391010282	phosphorylation site [posttranslational modification]
1116391010283	intermolecular recognition site; other site
1116391010284	dimerization interface [polypeptide binding]; other site
1116391010285	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010286	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010287	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391010288	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391010289	dimerization interface [polypeptide binding]; other site
1116391010290	Histidine kinase; Region: His_kinase; pfam06580
1116391010291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391010292	ATP binding site [chemical binding]; other site
1116391010293	Mg2+ binding site [ion binding]; other site
1116391010294	G-X-G motif; other site
1116391010295	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391010296	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1116391010297	putative active site [active]
1116391010298	putative metal binding site [ion binding]; other site
1116391010299	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
1116391010300	Asp-box motif; other site
1116391010301	BNR repeat-like domain; Region: BNR_2; pfam13088
1116391010302	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010304	dimer interface [polypeptide binding]; other site
1116391010305	conserved gate region; other site
1116391010306	putative PBP binding loops; other site
1116391010307	ABC-ATPase subunit interface; other site
1116391010308	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1116391010309	Yip1 domain; Region: Yip1; pfam04893
1116391010310	NHL repeat; Region: NHL; pfam01436
1116391010311	NHL repeat; Region: NHL; pfam01436
1116391010312	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1116391010313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391010314	TPR motif; other site
1116391010315	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010317	dimer interface [polypeptide binding]; other site
1116391010318	conserved gate region; other site
1116391010319	ABC-ATPase subunit interface; other site
1116391010320	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010322	dimer interface [polypeptide binding]; other site
1116391010323	conserved gate region; other site
1116391010324	putative PBP binding loops; other site
1116391010325	ABC-ATPase subunit interface; other site
1116391010326	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391010327	putative metal binding site [ion binding]; other site
1116391010328	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391010329	putative metal binding site [ion binding]; other site
1116391010330	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010331	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010332	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010333	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010334	Cupin domain; Region: Cupin_2; pfam07883
1116391010335	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010336	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010337	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010338	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391010339	Erythromycin esterase; Region: Erythro_esteras; cl17110
1116391010340	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1116391010341	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391010342	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391010343	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391010344	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1116391010345	trimer interface [polypeptide binding]; other site
1116391010346	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1116391010347	trimer interface [polypeptide binding]; other site
1116391010348	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
1116391010349	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1116391010350	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391010351	DNA binding residues [nucleotide binding]
1116391010352	dimerization interface [polypeptide binding]; other site
1116391010353	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391010354	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391010355	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1116391010356	putative catalytic site [active]
1116391010357	putative metal binding site [ion binding]; other site
1116391010358	putative phosphate binding site [ion binding]; other site
1116391010359	MAC/Perforin domain; Region: MACPF; cl02616
1116391010360	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1116391010361	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1116391010362	dimerization interface [polypeptide binding]; other site
1116391010363	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
1116391010364	mannose binding site [chemical binding]; other site
1116391010365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391010366	Coenzyme A binding pocket [chemical binding]; other site
1116391010367	beta-D-glucuronidase; Provisional; Region: PRK10150
1116391010368	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391010369	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391010370	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391010371	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010373	dimer interface [polypeptide binding]; other site
1116391010374	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1116391010375	ABC-ATPase subunit interface; other site
1116391010376	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010378	dimer interface [polypeptide binding]; other site
1116391010379	conserved gate region; other site
1116391010380	putative PBP binding loops; other site
1116391010381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391010382	ABC-ATPase subunit interface; other site
1116391010383	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010384	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010385	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010386	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010387	Condensation domain; Region: Condensation; pfam00668
1116391010388	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010389	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010390	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010391	acyl-activating enzyme (AAE) consensus motif; other site
1116391010392	AMP binding site [chemical binding]; other site
1116391010393	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010394	Condensation domain; Region: Condensation; pfam00668
1116391010395	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010396	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391010397	Condensation domain; Region: Condensation; pfam00668
1116391010398	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010399	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391010400	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391010401	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010402	acyl-activating enzyme (AAE) consensus motif; other site
1116391010403	AMP binding site [chemical binding]; other site
1116391010404	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010405	Condensation domain; Region: Condensation; pfam00668
1116391010406	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010407	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010408	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391010409	acyl-activating enzyme (AAE) consensus motif; other site
1116391010410	AMP binding site [chemical binding]; other site
1116391010411	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010412	Condensation domain; Region: Condensation; pfam00668
1116391010413	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010414	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010415	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010416	acyl-activating enzyme (AAE) consensus motif; other site
1116391010417	AMP binding site [chemical binding]; other site
1116391010418	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010419	Condensation domain; Region: Condensation; pfam00668
1116391010420	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010421	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010422	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010423	acyl-activating enzyme (AAE) consensus motif; other site
1116391010424	AMP binding site [chemical binding]; other site
1116391010425	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010426	Condensation domain; Region: Condensation; pfam00668
1116391010427	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010428	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010429	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010430	acyl-activating enzyme (AAE) consensus motif; other site
1116391010431	AMP binding site [chemical binding]; other site
1116391010432	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010433	Condensation domain; Region: Condensation; pfam00668
1116391010434	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010435	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010436	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391010437	acyl-activating enzyme (AAE) consensus motif; other site
1116391010438	AMP binding site [chemical binding]; other site
1116391010439	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010440	Condensation domain; Region: Condensation; pfam00668
1116391010441	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010442	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010443	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010444	acyl-activating enzyme (AAE) consensus motif; other site
1116391010445	AMP binding site [chemical binding]; other site
1116391010446	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010447	Condensation domain; Region: Condensation; pfam00668
1116391010448	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010449	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010450	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391010451	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391010452	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010453	acyl-activating enzyme (AAE) consensus motif; other site
1116391010454	AMP binding site [chemical binding]; other site
1116391010455	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010456	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391010457	active site
1116391010458	metal binding site [ion binding]; metal-binding site
1116391010459	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391010460	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1116391010461	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391010462	putative sugar binding sites [chemical binding]; other site
1116391010463	Q-X-W motif; other site
1116391010464	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391010465	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010466	active site
1116391010467	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010468	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010469	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1116391010470	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1116391010471	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391010472	MarR family; Region: MarR; pfam01047
1116391010473	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1116391010474	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391010475	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010477	dimer interface [polypeptide binding]; other site
1116391010478	conserved gate region; other site
1116391010479	putative PBP binding loops; other site
1116391010480	ABC-ATPase subunit interface; other site
1116391010481	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010482	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010483	dimer interface [polypeptide binding]; other site
1116391010484	conserved gate region; other site
1116391010485	ABC-ATPase subunit interface; other site
1116391010486	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010487	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010488	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010489	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1116391010491	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
1116391010492	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391010493	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391010494	Coenzyme A binding pocket [chemical binding]; other site
1116391010495	DinB superfamily; Region: DinB_2; pfam12867
1116391010496	DinB family; Region: DinB; cl17821
1116391010497	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391010498	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391010499	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391010500	Coenzyme A binding pocket [chemical binding]; other site
1116391010501	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1116391010502	active site
1116391010503	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391010504	DinB family; Region: DinB; cl17821
1116391010505	DinB superfamily; Region: DinB_2; pfam12867
1116391010506	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1116391010507	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391010508	Coenzyme A binding pocket [chemical binding]; other site
1116391010509	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1116391010510	ligand-binding site [chemical binding]; other site
1116391010511	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1116391010512	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391010513	FeS/SAM binding site; other site
1116391010514	coproporphyrinogen III oxidase; Validated; Region: PRK08208
1116391010515	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391010516	FeS/SAM binding site; other site
1116391010517	HemN C-terminal domain; Region: HemN_C; pfam06969
1116391010518	Sulfatase; Region: Sulfatase; cl17466
1116391010519	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
1116391010520	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1116391010521	Substrate binding site [chemical binding]; other site
1116391010522	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1116391010523	hydrophobic ligand binding site; other site
1116391010524	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1116391010525	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1116391010526	substrate binding pocket [chemical binding]; other site
1116391010527	catalytic triad [active]
1116391010528	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391010529	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391010530	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1116391010531	Walker A/P-loop; other site
1116391010532	ATP binding site [chemical binding]; other site
1116391010533	Q-loop/lid; other site
1116391010534	ABC transporter signature motif; other site
1116391010535	Walker B; other site
1116391010536	D-loop; other site
1116391010537	H-loop/switch region; other site
1116391010538	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391010539	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391010540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391010541	Walker A/P-loop; other site
1116391010542	ATP binding site [chemical binding]; other site
1116391010543	Q-loop/lid; other site
1116391010544	ABC transporter signature motif; other site
1116391010545	Walker B; other site
1116391010546	D-loop; other site
1116391010547	H-loop/switch region; other site
1116391010548	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391010549	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010550	dipeptidase PepV; Reviewed; Region: PRK07318
1116391010551	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1116391010552	active site
1116391010553	metal binding site [ion binding]; metal-binding site
1116391010554	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1116391010555	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1116391010556	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1116391010557	SnoaL-like domain; Region: SnoaL_2; pfam12680
1116391010558	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
1116391010559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
1116391010560	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391010561	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391010562	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1116391010563	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391010564	HTH domain; Region: HTH_11; pfam08279
1116391010565	WYL domain; Region: WYL; pfam13280
1116391010566	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1116391010567	dimer interface [polypeptide binding]; other site
1116391010568	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010569	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391010570	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391010571	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1116391010572	putative dimerization interface [polypeptide binding]; other site
1116391010573	OsmC-like protein; Region: OsmC; pfam02566
1116391010574	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1116391010575	substrate binding site [chemical binding]; other site
1116391010576	THF binding site; other site
1116391010577	zinc-binding site [ion binding]; other site
1116391010578	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1116391010579	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391010580	substrate binding pocket [chemical binding]; other site
1116391010581	membrane-bound complex binding site; other site
1116391010582	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1116391010583	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1116391010584	active site
1116391010585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391010586	active site
1116391010587	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391010588	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391010589	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391010590	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391010591	active site
1116391010592	phosphorylation site [posttranslational modification]
1116391010593	intermolecular recognition site; other site
1116391010594	dimerization interface [polypeptide binding]; other site
1116391010595	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010596	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010598	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391010599	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391010600	dimerization interface [polypeptide binding]; other site
1116391010601	Histidine kinase; Region: His_kinase; pfam06580
1116391010602	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010604	dimer interface [polypeptide binding]; other site
1116391010605	conserved gate region; other site
1116391010606	putative PBP binding loops; other site
1116391010607	ABC-ATPase subunit interface; other site
1116391010608	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010610	dimer interface [polypeptide binding]; other site
1116391010611	conserved gate region; other site
1116391010612	ABC-ATPase subunit interface; other site
1116391010613	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010614	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1116391010615	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1116391010616	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1116391010617	putative ligand binding site [chemical binding]; other site
1116391010618	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
1116391010619	Ca binding site [ion binding]; other site
1116391010620	carbohydrate binding site [chemical binding]; other site
1116391010621	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010623	dimer interface [polypeptide binding]; other site
1116391010624	conserved gate region; other site
1116391010625	ABC-ATPase subunit interface; other site
1116391010626	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010628	dimer interface [polypeptide binding]; other site
1116391010629	conserved gate region; other site
1116391010630	ABC-ATPase subunit interface; other site
1116391010631	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010632	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010633	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391010634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391010635	active site
1116391010636	phosphorylation site [posttranslational modification]
1116391010637	intermolecular recognition site; other site
1116391010638	dimerization interface [polypeptide binding]; other site
1116391010639	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1116391010640	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010641	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391010642	HAMP domain; Region: HAMP; pfam00672
1116391010643	Histidine kinase; Region: His_kinase; pfam06580
1116391010644	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391010645	ATP binding site [chemical binding]; other site
1116391010646	Mg2+ binding site [ion binding]; other site
1116391010647	G-X-G motif; other site
1116391010648	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391010649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391010650	active site
1116391010651	phosphorylation site [posttranslational modification]
1116391010652	intermolecular recognition site; other site
1116391010653	dimerization interface [polypeptide binding]; other site
1116391010654	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010655	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010656	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010657	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391010658	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391010659	dimerization interface [polypeptide binding]; other site
1116391010660	Histidine kinase; Region: His_kinase; pfam06580
1116391010661	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391010662	ATP binding site [chemical binding]; other site
1116391010663	Mg2+ binding site [ion binding]; other site
1116391010664	G-X-G motif; other site
1116391010665	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010666	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
1116391010667	substrate binding site [chemical binding]; other site
1116391010668	active site
1116391010669	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1116391010670	metal binding site [ion binding]; metal-binding site
1116391010671	ligand binding site [chemical binding]; other site
1116391010672	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1116391010673	metal binding site [ion binding]; metal-binding site
1116391010674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391010675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391010676	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1116391010677	dimerization interface [polypeptide binding]; other site
1116391010678	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1116391010679	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1116391010680	active site
1116391010681	FMN binding site [chemical binding]; other site
1116391010682	substrate binding site [chemical binding]; other site
1116391010683	putative catalytic residue [active]
1116391010684	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391010685	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391010686	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1116391010687	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391010688	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391010689	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391010690	Q-loop/lid; other site
1116391010691	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391010692	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391010693	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1116391010694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010695	dimer interface [polypeptide binding]; other site
1116391010696	conserved gate region; other site
1116391010697	putative PBP binding loops; other site
1116391010698	ABC-ATPase subunit interface; other site
1116391010699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010700	dimer interface [polypeptide binding]; other site
1116391010701	conserved gate region; other site
1116391010702	putative PBP binding loops; other site
1116391010703	ABC-ATPase subunit interface; other site
1116391010704	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1116391010705	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391010706	Walker A/P-loop; other site
1116391010707	ATP binding site [chemical binding]; other site
1116391010708	Q-loop/lid; other site
1116391010709	ABC transporter signature motif; other site
1116391010710	Walker B; other site
1116391010711	D-loop; other site
1116391010712	H-loop/switch region; other site
1116391010713	TOBE domain; Region: TOBE_2; pfam08402
1116391010714	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391010715	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1116391010716	putative hydrolase; Provisional; Region: PRK02113
1116391010717	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1116391010718	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1116391010719	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1116391010720	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391010721	DNA-binding site [nucleotide binding]; DNA binding site
1116391010722	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391010723	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1116391010724	ligand binding site [chemical binding]; other site
1116391010725	dimerization interface [polypeptide binding]; other site
1116391010726	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391010727	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391010728	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1116391010729	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391010730	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010731	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391010732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391010733	active site
1116391010734	phosphorylation site [posttranslational modification]
1116391010735	intermolecular recognition site; other site
1116391010736	dimerization interface [polypeptide binding]; other site
1116391010737	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010738	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010740	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391010741	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391010742	dimerization interface [polypeptide binding]; other site
1116391010743	Histidine kinase; Region: His_kinase; pfam06580
1116391010744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391010745	ATP binding site [chemical binding]; other site
1116391010746	Mg2+ binding site [ion binding]; other site
1116391010747	G-X-G motif; other site
1116391010748	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010749	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391010750	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391010751	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1116391010752	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010754	dimer interface [polypeptide binding]; other site
1116391010755	conserved gate region; other site
1116391010756	putative PBP binding loops; other site
1116391010757	ABC-ATPase subunit interface; other site
1116391010758	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391010759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010760	dimer interface [polypeptide binding]; other site
1116391010761	conserved gate region; other site
1116391010762	putative PBP binding loops; other site
1116391010763	ABC-ATPase subunit interface; other site
1116391010764	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391010765	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391010766	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1116391010767	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391010768	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391010769	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1116391010770	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391010771	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391010772	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391010773	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1116391010774	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391010775	putative active site [active]
1116391010776	putative metal binding site [ion binding]; other site
1116391010777	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1116391010778	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010779	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391010781	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391010782	putative substrate translocation pore; other site
1116391010783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391010784	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391010785	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391010786	short chain dehydrogenase; Provisional; Region: PRK06924
1116391010787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391010788	NAD(P) binding site [chemical binding]; other site
1116391010789	active site
1116391010790	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1116391010791	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1116391010792	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
1116391010793	putative NAD(P) binding site [chemical binding]; other site
1116391010794	active site
1116391010795	putative substrate binding site [chemical binding]; other site
1116391010796	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1116391010797	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
1116391010798	active site pocket [active]
1116391010799	oxyanion hole [active]
1116391010800	catalytic triad [active]
1116391010801	active site nucleophile [active]
1116391010802	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
1116391010803	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1116391010804	dimer interface [polypeptide binding]; other site
1116391010805	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010806	ligand binding site [chemical binding]; other site
1116391010807	Cupin domain; Region: Cupin_2; pfam07883
1116391010808	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391010809	MarR family; Region: MarR; pfam01047
1116391010810	hypothetical protein; Provisional; Region: PRK08244
1116391010811	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1116391010812	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1116391010813	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1116391010814	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391010815	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1116391010816	inhibitor binding site; inhibition site
1116391010817	active site
1116391010818	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010819	Cupin domain; Region: Cupin_2; cl17218
1116391010820	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391010821	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010822	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010823	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010824	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1116391010825	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391010826	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391010827	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
1116391010828	putative dimer interface [polypeptide binding]; other site
1116391010829	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391010830	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1116391010831	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1116391010832	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1116391010833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1116391010834	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1116391010835	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1116391010836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391010837	putative substrate translocation pore; other site
1116391010838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391010839	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391010840	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391010841	dimerization interface [polypeptide binding]; other site
1116391010842	putative DNA binding site [nucleotide binding]; other site
1116391010843	putative Zn2+ binding site [ion binding]; other site
1116391010844	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1116391010845	short chain dehydrogenase; Provisional; Region: PRK08263
1116391010846	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1116391010847	NADP binding site [chemical binding]; other site
1116391010848	active site
1116391010849	steroid binding site; other site
1116391010850	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391010851	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1116391010852	metal binding site [ion binding]; metal-binding site
1116391010853	ligand binding site [chemical binding]; other site
1116391010854	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391010855	glutamate dehydrogenase; Provisional; Region: PRK09414
1116391010856	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1116391010857	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1116391010858	NAD(P) binding site [chemical binding]; other site
1116391010859	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391010860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391010861	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1116391010862	putative dimerization interface [polypeptide binding]; other site
1116391010863	Creatinine amidohydrolase; Region: Creatininase; cl00618
1116391010864	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391010865	active site
1116391010866	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391010867	catalytic tetrad [active]
1116391010868	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1116391010869	[2Fe-2S] cluster binding site [ion binding]; other site
1116391010870	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1116391010871	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
1116391010872	putative di-iron ligands [ion binding]; other site
1116391010873	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391010874	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391010875	AP (apurinic/apyrimidinic) site pocket; other site
1116391010876	DNA interaction; other site
1116391010877	Metal-binding active site; metal-binding site
1116391010878	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391010879	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391010880	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1116391010881	active site
1116391010882	catalytic residues [active]
1116391010883	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391010884	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1116391010885	inhibitor binding site; inhibition site
1116391010886	active site
1116391010887	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010888	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010889	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010890	dimer interface [polypeptide binding]; other site
1116391010891	conserved gate region; other site
1116391010892	putative PBP binding loops; other site
1116391010893	ABC-ATPase subunit interface; other site
1116391010894	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391010895	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1116391010896	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1116391010897	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391010898	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391010899	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391010900	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1116391010901	active site 2 [active]
1116391010902	active site 1 [active]
1116391010903	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1116391010904	Amidohydrolase; Region: Amidohydro_2; pfam04909
1116391010905	active site
1116391010906	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1116391010907	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391010908	DNA-binding site [nucleotide binding]; DNA binding site
1116391010909	FCD domain; Region: FCD; pfam07729
1116391010910	Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; cl01770
1116391010911	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391010912	EamA-like transporter family; Region: EamA; pfam00892
1116391010913	S-layer homology domain; Region: SLH; pfam00395
1116391010914	S-layer homology domain; Region: SLH; pfam00395
1116391010915	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1116391010916	S-layer homology domain; Region: SLH; pfam00395
1116391010917	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1116391010918	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1116391010919	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1116391010920	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391010921	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391010922	putative DNA binding site [nucleotide binding]; other site
1116391010923	putative Zn2+ binding site [ion binding]; other site
1116391010924	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1116391010925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391010926	NAD(P) binding site [chemical binding]; other site
1116391010927	active site
1116391010928	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1116391010929	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391010930	salt bridge; other site
1116391010931	non-specific DNA binding site [nucleotide binding]; other site
1116391010932	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391010933	sequence-specific DNA binding site [nucleotide binding]; other site
1116391010934	PAS domain; Region: PAS; smart00091
1116391010935	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
1116391010936	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1116391010937	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1116391010938	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391010939	motif II; other site
1116391010940	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1116391010941	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010942	dimer interface [polypeptide binding]; other site
1116391010943	conserved gate region; other site
1116391010944	putative PBP binding loops; other site
1116391010945	ABC-ATPase subunit interface; other site
1116391010946	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391010947	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391010948	dimer interface [polypeptide binding]; other site
1116391010949	conserved gate region; other site
1116391010950	putative PBP binding loops; other site
1116391010951	ABC-ATPase subunit interface; other site
1116391010952	maltodextrin glucosidase; Provisional; Region: PRK10785
1116391010953	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1116391010954	homodimer interface [polypeptide binding]; other site
1116391010955	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1116391010956	active site
1116391010957	homodimer interface [polypeptide binding]; other site
1116391010958	catalytic site [active]
1116391010959	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391010960	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391010961	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1116391010962	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391010963	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391010964	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391010965	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391010966	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1116391010967	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1116391010968	active site
1116391010969	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1116391010970	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1116391010971	dimer interface [polypeptide binding]; other site
1116391010972	active site
1116391010973	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010974	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391010975	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1116391010976	NAD(P) binding site [chemical binding]; other site
1116391010977	homotetramer interface [polypeptide binding]; other site
1116391010978	homodimer interface [polypeptide binding]; other site
1116391010979	active site
1116391010980	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1116391010981	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1116391010982	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391010983	Methylamine utilisation protein MauE; Region: MauE; pfam07291
1116391010984	Condensation domain; Region: Condensation; pfam00668
1116391010985	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010986	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010987	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010988	acyl-activating enzyme (AAE) consensus motif; other site
1116391010989	AMP binding site [chemical binding]; other site
1116391010990	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010991	Condensation domain; Region: Condensation; pfam00668
1116391010992	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391010993	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391010994	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391010995	acyl-activating enzyme (AAE) consensus motif; other site
1116391010996	AMP binding site [chemical binding]; other site
1116391010997	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391010998	Condensation domain; Region: Condensation; pfam00668
1116391010999	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011000	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011001	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391011002	acyl-activating enzyme (AAE) consensus motif; other site
1116391011003	AMP binding site [chemical binding]; other site
1116391011004	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011005	Condensation domain; Region: Condensation; pfam00668
1116391011006	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011007	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1116391011008	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391011009	active site
1116391011010	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1116391011011	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1116391011012	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1116391011013	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1116391011014	putative NADP binding site [chemical binding]; other site
1116391011015	active site
1116391011016	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1116391011017	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1116391011018	peptide synthase; Provisional; Region: PRK12467
1116391011019	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011020	acyl-activating enzyme (AAE) consensus motif; other site
1116391011021	AMP binding site [chemical binding]; other site
1116391011022	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011023	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011024	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011025	acyl-activating enzyme (AAE) consensus motif; other site
1116391011026	AMP binding site [chemical binding]; other site
1116391011027	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011028	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011029	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011030	acyl-activating enzyme (AAE) consensus motif; other site
1116391011031	AMP binding site [chemical binding]; other site
1116391011032	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011033	Condensation domain; Region: Condensation; pfam00668
1116391011034	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011035	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1116391011036	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391011037	acyl-activating enzyme (AAE) consensus motif; other site
1116391011038	AMP binding site [chemical binding]; other site
1116391011039	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011040	Condensation domain; Region: Condensation; pfam00668
1116391011041	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011042	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011043	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391011044	acyl-activating enzyme (AAE) consensus motif; other site
1116391011045	AMP binding site [chemical binding]; other site
1116391011046	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011047	Condensation domain; Region: Condensation; pfam00668
1116391011048	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011049	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011050	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011051	acyl-activating enzyme (AAE) consensus motif; other site
1116391011052	AMP binding site [chemical binding]; other site
1116391011053	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011054	Condensation domain; Region: Condensation; pfam00668
1116391011055	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011056	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011057	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011058	acyl-activating enzyme (AAE) consensus motif; other site
1116391011059	AMP binding site [chemical binding]; other site
1116391011060	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011061	Condensation domain; Region: Condensation; pfam00668
1116391011062	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011063	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011064	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1116391011065	The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908
1116391011066	acyl-activating enzyme (AAE) consensus motif; other site
1116391011067	putative AMP binding site [chemical binding]; other site
1116391011068	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011069	Condensation domain; Region: Condensation; pfam00668
1116391011070	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011071	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011072	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391011073	acyl-activating enzyme (AAE) consensus motif; other site
1116391011074	AMP binding site [chemical binding]; other site
1116391011075	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011076	Condensation domain; Region: Condensation; pfam00668
1116391011077	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011078	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1116391011079	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391011080	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391011081	putative substrate translocation pore; other site
1116391011082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391011083	DNA binding residues [nucleotide binding]
1116391011084	Condensation domain; Region: Condensation; pfam00668
1116391011085	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011086	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391011087	acyl-activating enzyme (AAE) consensus motif; other site
1116391011088	AMP binding site [chemical binding]; other site
1116391011089	active site
1116391011090	CoA binding site [chemical binding]; other site
1116391011091	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011092	Condensation domain; Region: Condensation; pfam00668
1116391011093	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011094	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391011095	acyl-activating enzyme (AAE) consensus motif; other site
1116391011096	AMP binding site [chemical binding]; other site
1116391011097	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011098	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1116391011099	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011100	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391011101	acyl-activating enzyme (AAE) consensus motif; other site
1116391011102	AMP binding site [chemical binding]; other site
1116391011103	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011104	Condensation domain; Region: Condensation; pfam00668
1116391011105	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011106	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011107	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391011108	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391011109	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391011110	S-adenosylmethionine binding site [chemical binding]; other site
1116391011111	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011112	acyl-activating enzyme (AAE) consensus motif; other site
1116391011113	AMP binding site [chemical binding]; other site
1116391011114	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011115	Condensation domain; Region: Condensation; pfam00668
1116391011116	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011117	Condensation domain; Region: Condensation; pfam00668
1116391011118	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011119	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391011120	acyl-activating enzyme (AAE) consensus motif; other site
1116391011121	AMP binding site [chemical binding]; other site
1116391011122	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011123	Thioesterase domain; Region: Thioesterase; pfam00975
1116391011124	Condensation domain; Region: Condensation; pfam00668
1116391011125	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011126	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391011127	acyl-activating enzyme (AAE) consensus motif; other site
1116391011128	AMP binding site [chemical binding]; other site
1116391011129	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011130	Condensation domain; Region: Condensation; pfam00668
1116391011131	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011132	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011133	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391011134	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1116391011135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391011136	S-adenosylmethionine binding site [chemical binding]; other site
1116391011137	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011138	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391011139	acyl-activating enzyme (AAE) consensus motif; other site
1116391011140	AMP binding site [chemical binding]; other site
1116391011141	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011142	Condensation domain; Region: Condensation; pfam00668
1116391011143	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011144	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011145	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011146	acyl-activating enzyme (AAE) consensus motif; other site
1116391011147	AMP binding site [chemical binding]; other site
1116391011148	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011149	Condensation domain; Region: Condensation; pfam00668
1116391011150	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011151	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011152	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1116391011153	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1116391011154	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1116391011155	trimer interface [polypeptide binding]; other site
1116391011156	active site
1116391011157	substrate binding site [chemical binding]; other site
1116391011158	CoA binding site [chemical binding]; other site
1116391011159	Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057
1116391011160	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1116391011161	TrkA-N domain; Region: TrkA_N; pfam02254
1116391011162	TrkA-C domain; Region: TrkA_C; pfam02080
1116391011163	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391011164	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391011165	Transposase; Region: HTH_Tnp_1; cl17663
1116391011166	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391011167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391011168	HTH-like domain; Region: HTH_21; pfam13276
1116391011169	Integrase core domain; Region: rve; pfam00665
1116391011170	Integrase core domain; Region: rve_2; pfam13333
1116391011171	OsmC-like protein; Region: OsmC; pfam02566
1116391011172	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011173	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391011174	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011175	Ferredoxin [Energy production and conversion]; Region: COG1146
1116391011176	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1116391011177	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
1116391011178	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1116391011179	putative FMN binding site [chemical binding]; other site
1116391011180	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011181	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391011182	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391011183	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391011184	active site
1116391011185	non-prolyl cis peptide bond; other site
1116391011186	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1116391011187	dimer interface [polypeptide binding]; other site
1116391011188	FMN binding site [chemical binding]; other site
1116391011189	NADPH bind site [chemical binding]; other site
1116391011190	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391011191	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391011192	active site
1116391011193	non-prolyl cis peptide bond; other site
1116391011194	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391011195	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391011196	active site
1116391011197	catalytic tetrad [active]
1116391011198	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011199	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391011200	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391011201	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391011202	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391011203	active site
1116391011204	non-prolyl cis peptide bond; other site
1116391011205	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391011206	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391011207	active site
1116391011208	non-prolyl cis peptide bond; other site
1116391011209	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391011210	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391011211	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391011212	Walker A/P-loop; other site
1116391011213	ATP binding site [chemical binding]; other site
1116391011214	Q-loop/lid; other site
1116391011215	ABC transporter signature motif; other site
1116391011216	Walker B; other site
1116391011217	D-loop; other site
1116391011218	H-loop/switch region; other site
1116391011219	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391011220	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391011221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391011222	Walker A/P-loop; other site
1116391011223	ATP binding site [chemical binding]; other site
1116391011224	Q-loop/lid; other site
1116391011225	ABC transporter signature motif; other site
1116391011226	Walker B; other site
1116391011227	D-loop; other site
1116391011228	H-loop/switch region; other site
1116391011229	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391011230	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011231	dimer interface [polypeptide binding]; other site
1116391011232	conserved gate region; other site
1116391011233	putative PBP binding loops; other site
1116391011234	ABC-ATPase subunit interface; other site
1116391011235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011236	ABC-ATPase subunit interface; other site
1116391011237	putative PBP binding loops; other site
1116391011238	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1116391011239	NHL repeat; Region: NHL; pfam01436
1116391011240	NHL repeat; Region: NHL; pfam01436
1116391011241	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1116391011242	Yip1 domain; Region: Yip1; cl17815
1116391011243	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011245	dimer interface [polypeptide binding]; other site
1116391011246	conserved gate region; other site
1116391011247	putative PBP binding loops; other site
1116391011248	ABC-ATPase subunit interface; other site
1116391011249	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391011250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011251	dimer interface [polypeptide binding]; other site
1116391011252	conserved gate region; other site
1116391011253	putative PBP binding loops; other site
1116391011254	ABC-ATPase subunit interface; other site
1116391011255	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1116391011256	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1116391011257	Walker A/P-loop; other site
1116391011258	ATP binding site [chemical binding]; other site
1116391011259	Q-loop/lid; other site
1116391011260	ABC transporter signature motif; other site
1116391011261	Walker B; other site
1116391011262	D-loop; other site
1116391011263	H-loop/switch region; other site
1116391011264	TOBE domain; Region: TOBE_2; pfam08402
1116391011265	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1116391011266	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1116391011267	Cysteine-rich domain; Region: CCG; pfam02754
1116391011268	Cysteine-rich domain; Region: CCG; pfam02754
1116391011269	FAD binding domain; Region: FAD_binding_4; pfam01565
1116391011270	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1116391011271	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391011272	salt bridge; other site
1116391011273	non-specific DNA binding site [nucleotide binding]; other site
1116391011274	sequence-specific DNA binding site [nucleotide binding]; other site
1116391011275	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1116391011276	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1116391011277	putative catalytic site [active]
1116391011278	putative metal binding site [ion binding]; other site
1116391011279	putative phosphate binding site [ion binding]; other site
1116391011280	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1116391011281	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1116391011282	putative NAD(P) binding site [chemical binding]; other site
1116391011283	dimer interface [polypeptide binding]; other site
1116391011284	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1116391011285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391011286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391011287	putative substrate translocation pore; other site
1116391011288	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391011289	Helix-turn-helix domain; Region: HTH_31; pfam13560
1116391011290	salt bridge; other site
1116391011291	non-specific DNA binding site [nucleotide binding]; other site
1116391011292	sequence-specific DNA binding site [nucleotide binding]; other site
1116391011293	DinB family; Region: DinB; cl17821
1116391011294	DinB superfamily; Region: DinB_2; pfam12867
1116391011295	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391011296	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391011297	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1116391011298	dimerization interface [polypeptide binding]; other site
1116391011299	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391011300	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391011301	MarR family; Region: MarR_2; pfam12802
1116391011302	RibD C-terminal domain; Region: RibD_C; cl17279
1116391011303	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391011304	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1116391011305	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391011306	putative DNA binding site [nucleotide binding]; other site
1116391011307	putative Zn2+ binding site [ion binding]; other site
1116391011308	AsnC family; Region: AsnC_trans_reg; pfam01037
1116391011309	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1116391011310	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1116391011311	putative NAD(P) binding site [chemical binding]; other site
1116391011312	putative substrate binding site [chemical binding]; other site
1116391011313	catalytic Zn binding site [ion binding]; other site
1116391011314	structural Zn binding site [ion binding]; other site
1116391011315	dimer interface [polypeptide binding]; other site
1116391011316	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1116391011317	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1116391011318	dimer interface [polypeptide binding]; other site
1116391011319	PYR/PP interface [polypeptide binding]; other site
1116391011320	TPP binding site [chemical binding]; other site
1116391011321	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391011322	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1116391011323	TPP-binding site [chemical binding]; other site
1116391011324	dimer interface [polypeptide binding]; other site
1116391011325	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1116391011326	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391011327	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011328	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011329	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391011330	HAMP domain; Region: HAMP; pfam00672
1116391011331	dimerization interface [polypeptide binding]; other site
1116391011332	Histidine kinase; Region: His_kinase; pfam06580
1116391011333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391011334	ATP binding site [chemical binding]; other site
1116391011335	Mg2+ binding site [ion binding]; other site
1116391011336	G-X-G motif; other site
1116391011337	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011338	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011339	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011340	dimer interface [polypeptide binding]; other site
1116391011341	conserved gate region; other site
1116391011342	putative PBP binding loops; other site
1116391011343	ABC-ATPase subunit interface; other site
1116391011344	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391011345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011346	dimer interface [polypeptide binding]; other site
1116391011347	conserved gate region; other site
1116391011348	ABC-ATPase subunit interface; other site
1116391011349	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391011350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391011351	active site
1116391011352	phosphorylation site [posttranslational modification]
1116391011353	intermolecular recognition site; other site
1116391011354	dimerization interface [polypeptide binding]; other site
1116391011355	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011356	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391011357	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391011358	DNA-binding site [nucleotide binding]; DNA binding site
1116391011359	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391011360	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391011361	homodimer interface [polypeptide binding]; other site
1116391011362	catalytic residue [active]
1116391011363	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1116391011364	dimer interface [polypeptide binding]; other site
1116391011365	FMN binding site [chemical binding]; other site
1116391011366	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1116391011367	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391011368	sequence-specific DNA binding site [nucleotide binding]; other site
1116391011369	salt bridge; other site
1116391011370	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391011371	S-adenosylmethionine binding site [chemical binding]; other site
1116391011372	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1116391011373	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1116391011374	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391011375	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391011376	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391011377	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1116391011378	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391011379	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391011380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1116391011381	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391011382	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391011383	metal binding site [ion binding]; metal-binding site
1116391011384	active site
1116391011385	I-site; other site
1116391011386	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1116391011387	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391011388	dimerization interface [polypeptide binding]; other site
1116391011389	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391011390	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391011391	dimer interface [polypeptide binding]; other site
1116391011392	putative CheW interface [polypeptide binding]; other site
1116391011393	Cache domain; Region: Cache_1; pfam02743
1116391011394	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391011395	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391011396	dimerization interface [polypeptide binding]; other site
1116391011397	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391011398	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391011399	metal binding site [ion binding]; metal-binding site
1116391011400	active site
1116391011401	I-site; other site
1116391011402	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1116391011403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011404	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391011405	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011406	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1116391011407	Condensation domain; Region: Condensation; pfam00668
1116391011408	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011409	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011410	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011411	acyl-activating enzyme (AAE) consensus motif; other site
1116391011412	AMP binding site [chemical binding]; other site
1116391011413	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011414	Condensation domain; Region: Condensation; pfam00668
1116391011415	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011416	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1116391011417	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391011418	active site
1116391011419	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011420	Condensation domain; Region: Condensation; pfam00668
1116391011421	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011422	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391011423	acyl-activating enzyme (AAE) consensus motif; other site
1116391011424	AMP binding site [chemical binding]; other site
1116391011425	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011426	Condensation domain; Region: Condensation; pfam00668
1116391011427	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011428	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011429	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011430	acyl-activating enzyme (AAE) consensus motif; other site
1116391011431	AMP binding site [chemical binding]; other site
1116391011432	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011433	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1116391011434	conserved cys residue [active]
1116391011435	Putative amidotransferase; Region: DUF4066; pfam13278
1116391011436	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1116391011437	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391011438	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391011439	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011440	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391011441	acyl-activating enzyme (AAE) consensus motif; other site
1116391011442	AMP binding site [chemical binding]; other site
1116391011443	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011444	Condensation domain; Region: Condensation; pfam00668
1116391011445	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011446	Condensation domain; Region: Condensation; pfam00668
1116391011447	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011448	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011449	acyl-activating enzyme (AAE) consensus motif; other site
1116391011450	AMP binding site [chemical binding]; other site
1116391011451	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011452	Condensation domain; Region: Condensation; pfam00668
1116391011453	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011454	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011455	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391011456	acyl-activating enzyme (AAE) consensus motif; other site
1116391011457	AMP binding site [chemical binding]; other site
1116391011458	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011459	Condensation domain; Region: Condensation; pfam00668
1116391011460	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011461	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011462	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011463	acyl-activating enzyme (AAE) consensus motif; other site
1116391011464	AMP binding site [chemical binding]; other site
1116391011465	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011466	Condensation domain; Region: Condensation; pfam00668
1116391011467	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011468	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011469	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011470	acyl-activating enzyme (AAE) consensus motif; other site
1116391011471	AMP binding site [chemical binding]; other site
1116391011472	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011473	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1116391011474	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011475	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011476	acyl-activating enzyme (AAE) consensus motif; other site
1116391011477	AMP binding site [chemical binding]; other site
1116391011478	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011479	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1116391011480	Condensation domain; Region: Condensation; pfam00668
1116391011481	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011482	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391011483	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391011484	acyl-activating enzyme (AAE) consensus motif; other site
1116391011485	AMP binding site [chemical binding]; other site
1116391011486	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391011487	Condensation domain; Region: Condensation; pfam00668
1116391011488	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011489	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391011490	Condensation domain; Region: Condensation; pfam00668
1116391011491	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391011492	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1116391011493	Lipase (class 2); Region: Lipase_2; pfam01674
1116391011494	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391011495	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391011496	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391011497	NAD(P) binding site [chemical binding]; other site
1116391011498	active site
1116391011499	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391011500	active site
1116391011501	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1116391011502	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1116391011503	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
1116391011504	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1116391011505	Walker A/P-loop; other site
1116391011506	ATP binding site [chemical binding]; other site
1116391011507	Q-loop/lid; other site
1116391011508	ABC transporter signature motif; other site
1116391011509	Walker B; other site
1116391011510	D-loop; other site
1116391011511	H-loop/switch region; other site
1116391011512	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1116391011513	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391011514	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1116391011515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011516	dimer interface [polypeptide binding]; other site
1116391011517	conserved gate region; other site
1116391011518	ABC-ATPase subunit interface; other site
1116391011519	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1116391011520	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391011521	substrate binding pocket [chemical binding]; other site
1116391011522	membrane-bound complex binding site; other site
1116391011523	hinge residues; other site
1116391011524	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391011525	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1116391011526	DNA-binding site [nucleotide binding]; DNA binding site
1116391011527	FCD domain; Region: FCD; pfam07729
1116391011528	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391011529	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1116391011530	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1116391011531	EamA-like transporter family; Region: EamA; pfam00892
1116391011532	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391011533	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011534	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011535	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011536	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011538	dimer interface [polypeptide binding]; other site
1116391011539	conserved gate region; other site
1116391011540	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391011541	ABC-ATPase subunit interface; other site
1116391011542	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391011543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011544	ABC-ATPase subunit interface; other site
1116391011545	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391011546	Interdomain contacts; other site
1116391011547	Cytokine receptor motif; other site
1116391011548	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391011549	Interdomain contacts; other site
1116391011550	Cytokine receptor motif; other site
1116391011551	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391011552	Interdomain contacts; other site
1116391011553	Cytokine receptor motif; other site
1116391011554	putative pectinesterase; Region: PLN02432; cl01911
1116391011555	Pectinesterase; Region: Pectinesterase; pfam01095
1116391011556	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391011557	active site
1116391011558	catalytic triad [active]
1116391011559	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391011560	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391011561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011563	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1116391011564	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391011565	putative NAD(P) binding site [chemical binding]; other site
1116391011566	catalytic Zn binding site [ion binding]; other site
1116391011567	structural Zn binding site [ion binding]; other site
1116391011568	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391011569	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391011570	active site
1116391011571	catalytic tetrad [active]
1116391011572	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391011573	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391011574	DNA binding site [nucleotide binding]
1116391011575	domain linker motif; other site
1116391011576	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391011577	dimerization interface [polypeptide binding]; other site
1116391011578	ligand binding site [chemical binding]; other site
1116391011579	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1116391011580	classical (c) SDRs; Region: SDR_c; cd05233
1116391011581	NAD(P) binding site [chemical binding]; other site
1116391011582	active site
1116391011583	Cytochrome P450; Region: p450; cl12078
1116391011584	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391011585	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391011586	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391011587	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
1116391011588	Major royal jelly protein; Region: MRJP; pfam03022
1116391011589	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1116391011590	dimer interface [polypeptide binding]; other site
1116391011591	FMN binding site [chemical binding]; other site
1116391011592	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1116391011593	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391011594	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1116391011595	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1116391011596	Cellulose binding domain; Region: CBM_3; pfam00942
1116391011597	endoglucanase; Region: PLN02308
1116391011598	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
1116391011599	Cellulose binding domain; Region: CBM_3; pfam00942
1116391011600	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391011601	putative metal binding site [ion binding]; other site
1116391011602	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1116391011603	Cellulose binding domain; Region: CBM_3; pfam00942
1116391011604	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1116391011605	substrate binding site [chemical binding]; other site
1116391011606	active site
1116391011607	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1116391011608	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391011609	putative sugar binding sites [chemical binding]; other site
1116391011610	Q-X-W motif; other site
1116391011611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391011612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391011613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391011614	dimerization interface [polypeptide binding]; other site
1116391011615	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1116391011616	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1116391011617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391011618	putative substrate translocation pore; other site
1116391011619	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1116391011620	active site
1116391011621	catalytic triad [active]
1116391011622	oxyanion hole [active]
1116391011623	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1116391011624	Putative esterase; Region: Esterase; pfam00756
1116391011625	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391011626	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391011627	ABC-ATPase subunit  interface; other site
1116391011628	dimer interface [polypeptide binding]; other site
1116391011629	putative PBP binding regions; other site
1116391011630	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391011631	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391011632	ABC-ATPase subunit  interface; other site
1116391011633	dimer interface [polypeptide binding]; other site
1116391011634	putative PBP binding regions; other site
1116391011635	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1116391011636	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391011637	intersubunit interface [polypeptide binding]; other site
1116391011638	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391011639	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011640	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1116391011641	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391011642	intersubunit interface [polypeptide binding]; other site
1116391011643	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391011644	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1116391011645	NADP binding site [chemical binding]; other site
1116391011646	homodimer interface [polypeptide binding]; other site
1116391011647	active site
1116391011648	substrate binding site [chemical binding]; other site
1116391011649	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1116391011650	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011651	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391011652	Amb_all domain; Region: Amb_all; smart00656
1116391011653	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1116391011654	active site
1116391011655	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1116391011656	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1116391011657	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1116391011658	phosphate binding site [ion binding]; other site
1116391011659	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391011660	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391011661	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1116391011662	Walker A/P-loop; other site
1116391011663	ATP binding site [chemical binding]; other site
1116391011664	Q-loop/lid; other site
1116391011665	ABC transporter signature motif; other site
1116391011666	Walker B; other site
1116391011667	D-loop; other site
1116391011668	H-loop/switch region; other site
1116391011669	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391011670	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391011671	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1116391011672	putative dimerization interface [polypeptide binding]; other site
1116391011673	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1116391011674	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391011675	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391011676	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391011677	active site
1116391011678	non-prolyl cis peptide bond; other site
1116391011679	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391011680	substrate binding pocket [chemical binding]; other site
1116391011681	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1116391011682	membrane-bound complex binding site; other site
1116391011683	hinge residues; other site
1116391011684	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1116391011685	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1116391011686	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391011687	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391011688	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391011689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011690	dimer interface [polypeptide binding]; other site
1116391011691	conserved gate region; other site
1116391011692	putative PBP binding loops; other site
1116391011693	ABC-ATPase subunit interface; other site
1116391011694	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011695	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011696	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011698	dimer interface [polypeptide binding]; other site
1116391011699	conserved gate region; other site
1116391011700	ABC-ATPase subunit interface; other site
1116391011701	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391011702	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011703	dimer interface [polypeptide binding]; other site
1116391011704	conserved gate region; other site
1116391011705	ABC-ATPase subunit interface; other site
1116391011706	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391011707	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391011708	active site
1116391011709	phosphorylation site [posttranslational modification]
1116391011710	intermolecular recognition site; other site
1116391011711	dimerization interface [polypeptide binding]; other site
1116391011712	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011713	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391011714	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011715	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391011716	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391011717	dimerization interface [polypeptide binding]; other site
1116391011718	Histidine kinase; Region: His_kinase; pfam06580
1116391011719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391011720	ATP binding site [chemical binding]; other site
1116391011721	Mg2+ binding site [ion binding]; other site
1116391011722	G-X-G motif; other site
1116391011723	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
1116391011724	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1116391011725	Melibiase; Region: Melibiase; pfam02065
1116391011726	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391011727	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011728	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391011729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011730	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391011731	putative metal binding site [ion binding]; other site
1116391011732	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1116391011733	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1116391011734	hypothetical protein; Validated; Region: PRK00029
1116391011735	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391011736	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391011737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391011738	putative substrate translocation pore; other site
1116391011739	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1116391011740	FAD binding domain; Region: FAD_binding_4; pfam01565
1116391011741	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391011742	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
1116391011743	putative hydrophobic ligand binding site [chemical binding]; other site
1116391011744	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1116391011745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391011746	Predicted transcriptional regulator [Transcription]; Region: COG1959
1116391011747	Transcriptional regulator; Region: Rrf2; pfam02082
1116391011748	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391011749	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391011750	dimerization interface [polypeptide binding]; other site
1116391011751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391011752	dimer interface [polypeptide binding]; other site
1116391011753	phosphorylation site [posttranslational modification]
1116391011754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391011755	ATP binding site [chemical binding]; other site
1116391011756	Mg2+ binding site [ion binding]; other site
1116391011757	G-X-G motif; other site
1116391011758	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391011759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391011760	active site
1116391011761	phosphorylation site [posttranslational modification]
1116391011762	intermolecular recognition site; other site
1116391011763	dimerization interface [polypeptide binding]; other site
1116391011764	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391011765	FOG: CBS domain [General function prediction only]; Region: COG0517
1116391011766	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
1116391011767	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391011768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391011769	active site
1116391011770	phosphorylation site [posttranslational modification]
1116391011771	intermolecular recognition site; other site
1116391011772	dimerization interface [polypeptide binding]; other site
1116391011773	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391011774	DNA binding site [nucleotide binding]
1116391011775	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391011776	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391011777	dimerization interface [polypeptide binding]; other site
1116391011778	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391011779	dimer interface [polypeptide binding]; other site
1116391011780	phosphorylation site [posttranslational modification]
1116391011781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391011782	ATP binding site [chemical binding]; other site
1116391011783	Mg2+ binding site [ion binding]; other site
1116391011784	G-X-G motif; other site
1116391011785	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391011786	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1116391011787	Walker A/P-loop; other site
1116391011788	ATP binding site [chemical binding]; other site
1116391011789	Q-loop/lid; other site
1116391011790	ABC transporter signature motif; other site
1116391011791	Walker B; other site
1116391011792	D-loop; other site
1116391011793	H-loop/switch region; other site
1116391011794	L-fucose isomerase; Provisional; Region: fucI; PRK10991
1116391011795	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
1116391011796	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1116391011797	trimer interface [polypeptide binding]; other site
1116391011798	substrate binding site [chemical binding]; other site
1116391011799	Mn binding site [ion binding]; other site
1116391011800	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1116391011801	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1116391011802	inhibitor site; inhibition site
1116391011803	active site
1116391011804	dimer interface [polypeptide binding]; other site
1116391011805	catalytic residue [active]
1116391011806	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391011807	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391011808	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391011809	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391011810	Interdomain contacts; other site
1116391011811	Cytokine receptor motif; other site
1116391011812	putative pectinesterase; Region: PLN02432; cl01911
1116391011813	Pectinesterase; Region: Pectinesterase; pfam01095
1116391011814	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391011815	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
1116391011816	Abhydrolase family; Region: Abhydrolase_7; pfam12715
1116391011817	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391011818	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391011819	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391011820	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391011821	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391011822	Walker A/P-loop; other site
1116391011823	ATP binding site [chemical binding]; other site
1116391011824	Q-loop/lid; other site
1116391011825	ABC transporter signature motif; other site
1116391011826	Walker B; other site
1116391011827	D-loop; other site
1116391011828	H-loop/switch region; other site
1116391011829	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1116391011830	FtsX-like permease family; Region: FtsX; pfam02687
1116391011831	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391011832	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1116391011833	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391011834	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391011835	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391011836	Walker A/P-loop; other site
1116391011837	ATP binding site [chemical binding]; other site
1116391011838	Q-loop/lid; other site
1116391011839	ABC transporter signature motif; other site
1116391011840	Walker B; other site
1116391011841	D-loop; other site
1116391011842	H-loop/switch region; other site
1116391011843	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1116391011844	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391011845	DNA binding residues [nucleotide binding]
1116391011846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391011847	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391011848	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391011849	S-layer homology domain; Region: SLH; pfam00395
1116391011850	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011851	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011852	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011853	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011854	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011856	dimer interface [polypeptide binding]; other site
1116391011857	conserved gate region; other site
1116391011858	putative PBP binding loops; other site
1116391011859	ABC-ATPase subunit interface; other site
1116391011860	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391011861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011862	ABC-ATPase subunit interface; other site
1116391011863	NHL repeat; Region: NHL; pfam01436
1116391011864	Yip1 domain; Region: Yip1; pfam04893
1116391011865	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1116391011866	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391011867	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1116391011868	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1116391011869	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391011870	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391011871	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391011872	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391011873	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391011874	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391011875	Integrase core domain; Region: rve_3; pfam13683
1116391011876	Integrase core domain; Region: rve; pfam00665
1116391011877	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391011878	Transposase; Region: HTH_Tnp_1; cl17663
1116391011879	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1116391011880	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1116391011881	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391011883	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011884	dimer interface [polypeptide binding]; other site
1116391011885	conserved gate region; other site
1116391011886	ABC-ATPase subunit interface; other site
1116391011887	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011888	dimer interface [polypeptide binding]; other site
1116391011889	conserved gate region; other site
1116391011890	putative PBP binding loops; other site
1116391011891	ABC-ATPase subunit interface; other site
1116391011892	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391011893	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391011894	putative metal binding site [ion binding]; other site
1116391011895	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011896	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391011897	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1116391011898	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1116391011899	Walker A/P-loop; other site
1116391011900	ATP binding site [chemical binding]; other site
1116391011901	Q-loop/lid; other site
1116391011902	ABC transporter signature motif; other site
1116391011903	Walker B; other site
1116391011904	D-loop; other site
1116391011905	H-loop/switch region; other site
1116391011906	Abhydrolase family; Region: Abhydrolase_7; pfam12715
1116391011907	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391011908	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391011909	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011910	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011911	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1116391011912	BNR repeat-like domain; Region: BNR_2; pfam13088
1116391011913	Trehalase; Region: Trehalase; cl17346
1116391011914	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1116391011915	BNR repeat-like domain; Region: BNR_2; pfam13088
1116391011916	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
1116391011917	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1116391011918	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391011919	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391011920	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1116391011921	active site
1116391011922	catalytic triad [active]
1116391011923	oxyanion hole [active]
1116391011924	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1116391011925	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1116391011926	inhibitor site; inhibition site
1116391011927	active site
1116391011928	dimer interface [polypeptide binding]; other site
1116391011929	catalytic residue [active]
1116391011930	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1116391011931	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1116391011932	putative active site [active]
1116391011933	metal binding site [ion binding]; metal-binding site
1116391011934	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391011935	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
1116391011936	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391011937	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1116391011938	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1116391011939	HTH-like domain; Region: HTH_21; pfam13276
1116391011940	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391011941	Integrase core domain; Region: rve; pfam00665
1116391011942	Integrase core domain; Region: rve_3; pfam13683
1116391011943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391011944	Transposase; Region: HTH_Tnp_1; cl17663
1116391011945	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391011946	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011947	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1116391011948	ABC-ATPase subunit interface; other site
1116391011949	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391011950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391011951	dimer interface [polypeptide binding]; other site
1116391011952	conserved gate region; other site
1116391011953	ABC-ATPase subunit interface; other site
1116391011954	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391011955	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391011956	dimerization interface [polypeptide binding]; other site
1116391011957	Histidine kinase; Region: His_kinase; pfam06580
1116391011958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391011959	ATP binding site [chemical binding]; other site
1116391011960	Mg2+ binding site [ion binding]; other site
1116391011961	G-X-G motif; other site
1116391011962	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391011963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391011964	active site
1116391011965	phosphorylation site [posttranslational modification]
1116391011966	intermolecular recognition site; other site
1116391011967	dimerization interface [polypeptide binding]; other site
1116391011968	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391011969	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391011970	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391011971	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1116391011972	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1116391011973	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391011974	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391011975	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391011976	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391011977	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391011978	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391011979	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1116391011980	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391011981	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391011982	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1116391011983	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1116391011984	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1116391011985	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
1116391011986	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
1116391011987	dimer interface [polypeptide binding]; other site
1116391011988	active site
1116391011989	catalytic residue [active]
1116391011990	metal binding site [ion binding]; metal-binding site
1116391011991	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1116391011992	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1116391011993	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1116391011994	active site
1116391011995	intersubunit interface [polypeptide binding]; other site
1116391011996	catalytic residue [active]
1116391011997	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391011998	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391011999	NAD(P) binding site [chemical binding]; other site
1116391012000	active site
1116391012001	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1116391012002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1116391012003	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391012004	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012005	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1116391012006	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1116391012007	N- and C-terminal domain interface [polypeptide binding]; other site
1116391012008	active site
1116391012009	MgATP binding site [chemical binding]; other site
1116391012010	catalytic site [active]
1116391012011	metal binding site [ion binding]; metal-binding site
1116391012012	glycerol binding site [chemical binding]; other site
1116391012013	homotetramer interface [polypeptide binding]; other site
1116391012014	homodimer interface [polypeptide binding]; other site
1116391012015	FBP binding site [chemical binding]; other site
1116391012016	protein IIAGlc interface [polypeptide binding]; other site
1116391012017	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1116391012018	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1116391012019	PYR/PP interface [polypeptide binding]; other site
1116391012020	dimer interface [polypeptide binding]; other site
1116391012021	TPP binding site [chemical binding]; other site
1116391012022	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391012023	transketolase; Reviewed; Region: PRK05899
1116391012024	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1116391012025	TPP-binding site [chemical binding]; other site
1116391012026	dimer interface [polypeptide binding]; other site
1116391012027	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
1116391012028	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1116391012029	substrate binding site [chemical binding]; other site
1116391012030	trimer interface [polypeptide binding]; other site
1116391012031	Mn binding site [ion binding]; other site
1116391012032	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391012033	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391012034	DNA binding site [nucleotide binding]
1116391012035	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391012036	ligand binding site [chemical binding]; other site
1116391012037	dimerization interface [polypeptide binding]; other site
1116391012038	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391012039	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012040	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012041	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012042	putative alpha-glucosidase; Provisional; Region: PRK10658
1116391012043	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1116391012044	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1116391012045	active site
1116391012046	homotrimer interface [polypeptide binding]; other site
1116391012047	catalytic site [active]
1116391012048	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1116391012049	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
1116391012050	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1116391012051	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1116391012052	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1116391012053	conserved cys residue [active]
1116391012054	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1116391012055	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1116391012056	Spore germination protein; Region: Spore_permease; cl17796
1116391012057	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391012058	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391012059	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391012060	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1116391012061	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1116391012062	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1116391012063	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391012064	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391012065	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391012066	ligand binding site [chemical binding]; other site
1116391012067	flexible hinge region; other site
1116391012068	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1116391012069	non-specific DNA interactions [nucleotide binding]; other site
1116391012070	DNA binding site [nucleotide binding]
1116391012071	sequence specific DNA binding site [nucleotide binding]; other site
1116391012072	putative cAMP binding site [chemical binding]; other site
1116391012073	DoxX-like family; Region: DoxX_2; pfam13564
1116391012074	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
1116391012075	ADP-ribose binding site [chemical binding]; other site
1116391012076	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391012077	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
1116391012078	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
1116391012079	MutS domain III; Region: MutS_III; pfam05192
1116391012080	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391012081	Walker A/P-loop; other site
1116391012082	ATP binding site [chemical binding]; other site
1116391012083	Q-loop/lid; other site
1116391012084	ABC transporter signature motif; other site
1116391012085	Walker B; other site
1116391012086	D-loop; other site
1116391012087	H-loop/switch region; other site
1116391012088	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391012089	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391012090	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012091	active site
1116391012092	phosphorylation site [posttranslational modification]
1116391012093	intermolecular recognition site; other site
1116391012094	dimerization interface [polypeptide binding]; other site
1116391012095	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391012096	DNA binding site [nucleotide binding]
1116391012097	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391012098	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391012099	dimerization interface [polypeptide binding]; other site
1116391012100	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391012101	dimer interface [polypeptide binding]; other site
1116391012102	phosphorylation site [posttranslational modification]
1116391012103	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012104	ATP binding site [chemical binding]; other site
1116391012105	Mg2+ binding site [ion binding]; other site
1116391012106	G-X-G motif; other site
1116391012107	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012108	putative substrate translocation pore; other site
1116391012109	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1116391012110	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1116391012111	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391012112	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1116391012113	dimer interface [polypeptide binding]; other site
1116391012114	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391012115	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391012116	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391012117	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391012118	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391012119	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391012120	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391012121	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1116391012122	putative NAD(P) binding site [chemical binding]; other site
1116391012123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012124	putative substrate translocation pore; other site
1116391012125	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391012127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391012128	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1116391012129	dimerization interface [polypeptide binding]; other site
1116391012130	DNA binding domain, excisionase family; Region: excise; TIGR01764
1116391012131	PBP superfamily domain; Region: PBP_like; pfam12727
1116391012132	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1116391012133	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1116391012134	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1116391012135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012136	dimer interface [polypeptide binding]; other site
1116391012137	ABC-ATPase subunit interface; other site
1116391012138	putative PBP binding loops; other site
1116391012139	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1116391012140	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
1116391012141	active site
1116391012142	substrate binding site [chemical binding]; other site
1116391012143	ATP binding site [chemical binding]; other site
1116391012144	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391012145	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012146	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012147	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012148	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012150	dimer interface [polypeptide binding]; other site
1116391012151	conserved gate region; other site
1116391012152	putative PBP binding loops; other site
1116391012153	ABC-ATPase subunit interface; other site
1116391012154	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391012155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012156	dimer interface [polypeptide binding]; other site
1116391012157	conserved gate region; other site
1116391012158	ABC-ATPase subunit interface; other site
1116391012159	Domain of unknown function (DUF303); Region: DUF303; pfam03629
1116391012160	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391012161	Cytochrome P450; Region: p450; cl12078
1116391012162	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391012163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012164	active site
1116391012165	phosphorylation site [posttranslational modification]
1116391012166	intermolecular recognition site; other site
1116391012167	dimerization interface [polypeptide binding]; other site
1116391012168	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391012169	DNA binding site [nucleotide binding]
1116391012170	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391012171	dimerization interface [polypeptide binding]; other site
1116391012172	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391012173	dimer interface [polypeptide binding]; other site
1116391012174	phosphorylation site [posttranslational modification]
1116391012175	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012176	ATP binding site [chemical binding]; other site
1116391012177	Mg2+ binding site [ion binding]; other site
1116391012178	G-X-G motif; other site
1116391012179	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391012180	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391012181	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391012182	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012183	putative substrate translocation pore; other site
1116391012184	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1116391012185	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1116391012186	THF binding site; other site
1116391012187	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1116391012188	substrate binding site [chemical binding]; other site
1116391012189	THF binding site; other site
1116391012190	zinc-binding site [ion binding]; other site
1116391012191	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391012192	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391012193	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391012194	dimerization interface [polypeptide binding]; other site
1116391012195	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391012196	putative pectinesterase; Region: PLN02432; cl01911
1116391012197	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391012198	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391012199	metal binding site [ion binding]; metal-binding site
1116391012200	Family description; Region: VCBS; pfam13517
1116391012201	active site
1116391012202	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391012203	Interdomain contacts; other site
1116391012204	Cytokine receptor motif; other site
1116391012205	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391012206	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391012207	active site
1116391012208	metal binding site [ion binding]; metal-binding site
1116391012209	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391012210	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391012211	active site
1116391012212	catalytic tetrad [active]
1116391012213	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391012214	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391012215	DNA-binding site [nucleotide binding]; DNA binding site
1116391012216	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391012217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391012218	homodimer interface [polypeptide binding]; other site
1116391012219	catalytic residue [active]
1116391012220	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1116391012221	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391012222	Condensation domain; Region: Condensation; pfam00668
1116391012223	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012224	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391012225	acyl-activating enzyme (AAE) consensus motif; other site
1116391012226	AMP binding site [chemical binding]; other site
1116391012227	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012228	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1116391012229	Condensation domain; Region: Condensation; pfam00668
1116391012230	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012231	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391012232	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391012233	acyl-activating enzyme (AAE) consensus motif; other site
1116391012234	AMP binding site [chemical binding]; other site
1116391012235	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012236	Condensation domain; Region: Condensation; pfam00668
1116391012237	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012238	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391012239	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
1116391012240	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1116391012241	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1116391012242	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1116391012243	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1116391012244	active site
1116391012245	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1116391012246	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1116391012247	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1116391012248	putative NADP binding site [chemical binding]; other site
1116391012249	active site
1116391012250	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012251	Condensation domain; Region: Condensation; pfam00668
1116391012252	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391012253	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391012254	acyl-activating enzyme (AAE) consensus motif; other site
1116391012255	AMP binding site [chemical binding]; other site
1116391012256	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012257	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012259	dimer interface [polypeptide binding]; other site
1116391012260	conserved gate region; other site
1116391012261	putative PBP binding loops; other site
1116391012262	ABC-ATPase subunit interface; other site
1116391012263	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391012264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012265	putative PBP binding loops; other site
1116391012266	dimer interface [polypeptide binding]; other site
1116391012267	ABC-ATPase subunit interface; other site
1116391012268	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012269	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012270	Histidine kinase; Region: His_kinase; pfam06580
1116391012271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012272	ATP binding site [chemical binding]; other site
1116391012273	Mg2+ binding site [ion binding]; other site
1116391012274	G-X-G motif; other site
1116391012275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012276	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391012277	active site
1116391012278	phosphorylation site [posttranslational modification]
1116391012279	intermolecular recognition site; other site
1116391012280	dimerization interface [polypeptide binding]; other site
1116391012281	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391012282	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012283	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1116391012284	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391012285	DNA binding residues [nucleotide binding]
1116391012286	dimer interface [polypeptide binding]; other site
1116391012287	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1116391012288	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1116391012289	dimer interface [polypeptide binding]; other site
1116391012290	active site
1116391012291	catalytic residue [active]
1116391012292	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391012293	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391012294	haloalkane dehalogenase; Provisional; Region: PRK03204
1116391012295	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1116391012296	RibD C-terminal domain; Region: RibD_C; cl17279
1116391012297	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012298	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012299	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391012300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012301	dimer interface [polypeptide binding]; other site
1116391012302	conserved gate region; other site
1116391012303	putative PBP binding loops; other site
1116391012304	ABC-ATPase subunit interface; other site
1116391012305	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012307	dimer interface [polypeptide binding]; other site
1116391012308	conserved gate region; other site
1116391012309	putative PBP binding loops; other site
1116391012310	ABC-ATPase subunit interface; other site
1116391012311	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391012312	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391012313	dimerization interface [polypeptide binding]; other site
1116391012314	Histidine kinase; Region: His_kinase; pfam06580
1116391012315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012316	ATP binding site [chemical binding]; other site
1116391012317	Mg2+ binding site [ion binding]; other site
1116391012318	G-X-G motif; other site
1116391012319	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391012320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012321	active site
1116391012322	phosphorylation site [posttranslational modification]
1116391012323	intermolecular recognition site; other site
1116391012324	dimerization interface [polypeptide binding]; other site
1116391012325	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391012326	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012327	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012328	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1116391012329	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1116391012330	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1116391012331	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391012332	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1116391012333	DNA binding residues [nucleotide binding]
1116391012334	putative dimer interface [polypeptide binding]; other site
1116391012335	EamA-like transporter family; Region: EamA; cl17759
1116391012336	EamA-like transporter family; Region: EamA; pfam00892
1116391012337	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391012338	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391012339	active site
1116391012340	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012342	dimer interface [polypeptide binding]; other site
1116391012343	conserved gate region; other site
1116391012344	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391012345	ABC-ATPase subunit interface; other site
1116391012346	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391012347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012348	dimer interface [polypeptide binding]; other site
1116391012349	conserved gate region; other site
1116391012350	putative PBP binding loops; other site
1116391012351	ABC-ATPase subunit interface; other site
1116391012352	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012355	active site
1116391012356	phosphorylation site [posttranslational modification]
1116391012357	intermolecular recognition site; other site
1116391012358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012359	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012360	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012361	Histidine kinase; Region: His_kinase; pfam06580
1116391012362	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012363	ATP binding site [chemical binding]; other site
1116391012364	Mg2+ binding site [ion binding]; other site
1116391012365	G-X-G motif; other site
1116391012366	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1116391012367	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1116391012368	active site
1116391012369	ATP binding site [chemical binding]; other site
1116391012370	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1116391012371	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391012372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391012373	DNA binding residues [nucleotide binding]
1116391012374	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391012375	Cytochrome P450; Region: p450; cl12078
1116391012376	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1116391012377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012378	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1116391012379	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1116391012380	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391012381	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012382	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012383	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012384	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391012385	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391012386	DNA-binding site [nucleotide binding]; DNA binding site
1116391012387	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391012388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391012389	homodimer interface [polypeptide binding]; other site
1116391012390	catalytic residue [active]
1116391012391	glycerate kinase; Region: TIGR00045
1116391012392	CAAX protease self-immunity; Region: Abi; pfam02517
1116391012393	putative acetyltransferase; Provisional; Region: PRK03624
1116391012394	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391012395	Coenzyme A binding pocket [chemical binding]; other site
1116391012396	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1116391012397	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1116391012398	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012399	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1116391012401	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1116391012402	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012403	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012404	active site
1116391012405	phosphorylation site [posttranslational modification]
1116391012406	intermolecular recognition site; other site
1116391012407	dimerization interface [polypeptide binding]; other site
1116391012408	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391012409	non-specific DNA binding site [nucleotide binding]; other site
1116391012410	salt bridge; other site
1116391012411	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012412	sequence-specific DNA binding site [nucleotide binding]; other site
1116391012413	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012414	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391012415	dimerization interface [polypeptide binding]; other site
1116391012416	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391012417	Histidine kinase; Region: His_kinase; pfam06580
1116391012418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012419	ATP binding site [chemical binding]; other site
1116391012420	Mg2+ binding site [ion binding]; other site
1116391012421	G-X-G motif; other site
1116391012422	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012423	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012424	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391012425	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391012426	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012427	active site
1116391012428	phosphorylation site [posttranslational modification]
1116391012429	intermolecular recognition site; other site
1116391012430	dimerization interface [polypeptide binding]; other site
1116391012431	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391012433	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391012434	dimerization interface [polypeptide binding]; other site
1116391012435	Histidine kinase; Region: His_kinase; pfam06580
1116391012436	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012437	ATP binding site [chemical binding]; other site
1116391012438	Mg2+ binding site [ion binding]; other site
1116391012439	G-X-G motif; other site
1116391012440	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012441	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012442	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012444	dimer interface [polypeptide binding]; other site
1116391012445	ABC-ATPase subunit interface; other site
1116391012446	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391012447	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012448	dimer interface [polypeptide binding]; other site
1116391012449	conserved gate region; other site
1116391012450	ABC-ATPase subunit interface; other site
1116391012451	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391012452	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391012453	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391012454	Interdomain contacts; other site
1116391012455	Cytokine receptor motif; other site
1116391012456	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391012457	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391012458	Interdomain contacts; other site
1116391012459	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1116391012460	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1116391012461	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
1116391012462	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391012463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391012464	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391012465	dimerization interface [polypeptide binding]; other site
1116391012466	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391012467	EamA-like transporter family; Region: EamA; pfam00892
1116391012468	EamA-like transporter family; Region: EamA; pfam00892
1116391012469	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391012470	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391012471	active site
1116391012472	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1116391012473	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1116391012474	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
1116391012475	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391012476	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391012477	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391012478	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
1116391012479	NAD(P) binding site [chemical binding]; other site
1116391012480	active site
1116391012481	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391012482	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391012483	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391012484	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391012485	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1116391012486	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1116391012487	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1116391012488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012489	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391012490	putative substrate translocation pore; other site
1116391012491	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1116391012492	hypothetical protein; Provisional; Region: PRK07206
1116391012493	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391012494	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1116391012495	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391012496	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391012497	putative substrate translocation pore; other site
1116391012498	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1116391012499	PYR/PP interface [polypeptide binding]; other site
1116391012500	dimer interface [polypeptide binding]; other site
1116391012501	TPP binding site [chemical binding]; other site
1116391012502	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1116391012503	TPP-binding site [chemical binding]; other site
1116391012504	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1116391012505	substrate binding site [chemical binding]; other site
1116391012506	nucleotide binding site [chemical binding]; other site
1116391012507	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1116391012508	N-acetyl-ornithine/N-acetyl-lysine deacetylase; Region: dapE-lys-deAc; TIGR01902
1116391012509	metal binding site [ion binding]; metal-binding site
1116391012510	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1116391012511	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1116391012512	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1116391012513	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1116391012514	inhibitor-cofactor binding pocket; inhibition site
1116391012515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391012516	catalytic residue [active]
1116391012517	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1116391012518	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
1116391012519	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1116391012520	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
1116391012521	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1116391012522	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1116391012523	catalytic triad [active]
1116391012524	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1116391012525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012526	dimer interface [polypeptide binding]; other site
1116391012527	conserved gate region; other site
1116391012528	putative PBP binding loops; other site
1116391012529	ABC-ATPase subunit interface; other site
1116391012530	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391012531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012532	dimer interface [polypeptide binding]; other site
1116391012533	conserved gate region; other site
1116391012534	putative PBP binding loops; other site
1116391012535	ABC-ATPase subunit interface; other site
1116391012536	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1116391012537	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391012538	Walker A/P-loop; other site
1116391012539	ATP binding site [chemical binding]; other site
1116391012540	Q-loop/lid; other site
1116391012541	ABC transporter signature motif; other site
1116391012542	Walker B; other site
1116391012543	D-loop; other site
1116391012544	H-loop/switch region; other site
1116391012545	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391012546	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391012547	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391012548	Walker A/P-loop; other site
1116391012549	ATP binding site [chemical binding]; other site
1116391012550	Q-loop/lid; other site
1116391012551	ABC transporter signature motif; other site
1116391012552	Walker B; other site
1116391012553	D-loop; other site
1116391012554	H-loop/switch region; other site
1116391012555	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391012556	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391012557	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1116391012558	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012560	dimer interface [polypeptide binding]; other site
1116391012561	conserved gate region; other site
1116391012562	putative PBP binding loops; other site
1116391012563	ABC-ATPase subunit interface; other site
1116391012564	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391012565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391012566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012567	putative PBP binding loops; other site
1116391012568	dimer interface [polypeptide binding]; other site
1116391012569	ABC-ATPase subunit interface; other site
1116391012570	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012571	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012572	Amidohydrolase; Region: Amidohydro_2; pfam04909
1116391012573	argininosuccinate lyase; Provisional; Region: PRK06705
1116391012574	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1116391012575	active sites [active]
1116391012576	tetramer interface [polypeptide binding]; other site
1116391012577	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1116391012578	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1116391012579	active site
1116391012580	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1116391012581	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1116391012582	active site
1116391012583	dimer interface [polypeptide binding]; other site
1116391012584	non-prolyl cis peptide bond; other site
1116391012585	insertion regions; other site
1116391012586	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1116391012587	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1116391012588	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1116391012589	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391012590	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391012592	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391012593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012594	dimer interface [polypeptide binding]; other site
1116391012595	conserved gate region; other site
1116391012596	putative PBP binding loops; other site
1116391012597	ABC-ATPase subunit interface; other site
1116391012598	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012599	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012600	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1116391012601	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1116391012602	active site
1116391012603	dimer interface [polypeptide binding]; other site
1116391012604	non-prolyl cis peptide bond; other site
1116391012605	insertion regions; other site
1116391012606	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391012607	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391012608	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012610	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012611	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012612	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012613	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1116391012614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391012615	NAD(P) binding site [chemical binding]; other site
1116391012616	active site
1116391012617	SnoaL-like domain; Region: SnoaL_4; pfam13577
1116391012618	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
1116391012619	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391012620	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391012621	active site
1116391012622	non-prolyl cis peptide bond; other site
1116391012623	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1116391012624	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1116391012625	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391012626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391012627	Coenzyme A binding pocket [chemical binding]; other site
1116391012628	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1116391012629	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1116391012630	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1116391012631	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1116391012632	metal binding site [ion binding]; metal-binding site
1116391012633	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391012634	Coenzyme A binding pocket [chemical binding]; other site
1116391012635	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391012636	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391012637	Walker A/P-loop; other site
1116391012638	ATP binding site [chemical binding]; other site
1116391012639	Q-loop/lid; other site
1116391012640	ABC transporter signature motif; other site
1116391012641	Walker B; other site
1116391012642	D-loop; other site
1116391012643	H-loop/switch region; other site
1116391012644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012645	dimer interface [polypeptide binding]; other site
1116391012646	conserved gate region; other site
1116391012647	putative PBP binding loops; other site
1116391012648	ABC-ATPase subunit interface; other site
1116391012649	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391012650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012651	dimer interface [polypeptide binding]; other site
1116391012652	conserved gate region; other site
1116391012653	putative PBP binding loops; other site
1116391012654	ABC-ATPase subunit interface; other site
1116391012655	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391012656	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391012657	substrate binding pocket [chemical binding]; other site
1116391012658	membrane-bound complex binding site; other site
1116391012659	hinge residues; other site
1116391012660	DinB superfamily; Region: DinB_2; pfam12867
1116391012661	metal-dependent hydrolase; Provisional; Region: PRK13291
1116391012662	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391012663	Q-loop/lid; other site
1116391012664	ABC transporter signature motif; other site
1116391012665	Walker B; other site
1116391012666	D-loop; other site
1116391012667	H-loop/switch region; other site
1116391012668	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391012669	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391012670	Walker A/P-loop; other site
1116391012671	ATP binding site [chemical binding]; other site
1116391012672	Q-loop/lid; other site
1116391012673	ABC transporter signature motif; other site
1116391012674	Walker B; other site
1116391012675	D-loop; other site
1116391012676	H-loop/switch region; other site
1116391012677	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391012678	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1116391012679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012680	ABC-ATPase subunit interface; other site
1116391012681	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391012682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012683	dimer interface [polypeptide binding]; other site
1116391012684	conserved gate region; other site
1116391012685	putative PBP binding loops; other site
1116391012686	ABC-ATPase subunit interface; other site
1116391012687	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391012688	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1116391012689	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391012690	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391012691	active site
1116391012692	non-prolyl cis peptide bond; other site
1116391012693	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1116391012694	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1116391012695	cell density-dependent motility repressor; Provisional; Region: PRK10082
1116391012696	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391012697	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391012698	dimerization interface [polypeptide binding]; other site
1116391012699	DoxX-like family; Region: DoxX_2; pfam13564
1116391012700	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1116391012701	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1116391012702	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1116391012703	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1116391012704	Sulfatase; Region: Sulfatase; pfam00884
1116391012705	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1116391012706	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1116391012707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012708	dimer interface [polypeptide binding]; other site
1116391012709	conserved gate region; other site
1116391012710	putative PBP binding loops; other site
1116391012711	ABC-ATPase subunit interface; other site
1116391012712	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391012713	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391012714	Walker A/P-loop; other site
1116391012715	ATP binding site [chemical binding]; other site
1116391012716	Q-loop/lid; other site
1116391012717	ABC transporter signature motif; other site
1116391012718	Walker B; other site
1116391012719	D-loop; other site
1116391012720	H-loop/switch region; other site
1116391012721	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1116391012722	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391012723	substrate binding pocket [chemical binding]; other site
1116391012724	membrane-bound complex binding site; other site
1116391012725	hinge residues; other site
1116391012726	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391012727	MarR family; Region: MarR; pfam01047
1116391012728	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1116391012729	Sulfatase; Region: Sulfatase; cl17466
1116391012730	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012731	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391012732	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391012733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012734	dimer interface [polypeptide binding]; other site
1116391012735	conserved gate region; other site
1116391012736	ABC-ATPase subunit interface; other site
1116391012737	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012738	N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320
1116391012739	active site
1116391012740	catalytic site [active]
1116391012741	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
1116391012742	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
1116391012743	Ca binding site [ion binding]; other site
1116391012744	substrate binding site [chemical binding]; other site
1116391012745	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391012746	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012747	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391012748	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012749	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
1116391012750	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391012751	active site
1116391012752	non-prolyl cis peptide bond; other site
1116391012753	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391012754	active site
1116391012755	metal binding site [ion binding]; metal-binding site
1116391012756	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391012757	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1116391012758	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391012759	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1116391012760	DNA binding residues [nucleotide binding]
1116391012761	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
1116391012762	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1116391012763	nudix motif; other site
1116391012764	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1116391012765	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1116391012766	NADP binding site [chemical binding]; other site
1116391012767	homodimer interface [polypeptide binding]; other site
1116391012768	active site
1116391012769	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1116391012770	dimer interface [polypeptide binding]; other site
1116391012771	substrate binding site [chemical binding]; other site
1116391012772	metal binding site [ion binding]; metal-binding site
1116391012773	Protein of unknown function (DUF817); Region: DUF817; pfam05675
1116391012774	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1116391012775	metal-binding site [ion binding]
1116391012776	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391012777	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391012778	DNA binding site [nucleotide binding]
1116391012779	domain linker motif; other site
1116391012780	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391012781	dimerization interface [polypeptide binding]; other site
1116391012782	ligand binding site [chemical binding]; other site
1116391012783	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391012784	dimerization interface [polypeptide binding]; other site
1116391012785	putative DNA binding site [nucleotide binding]; other site
1116391012786	putative Zn2+ binding site [ion binding]; other site
1116391012787	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391012788	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391012789	dimer interface [polypeptide binding]; other site
1116391012790	phosphorylation site [posttranslational modification]
1116391012791	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012792	ATP binding site [chemical binding]; other site
1116391012793	Mg2+ binding site [ion binding]; other site
1116391012794	G-X-G motif; other site
1116391012795	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391012796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012797	active site
1116391012798	phosphorylation site [posttranslational modification]
1116391012799	intermolecular recognition site; other site
1116391012800	dimerization interface [polypeptide binding]; other site
1116391012801	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391012802	DNA binding site [nucleotide binding]
1116391012803	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1116391012804	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1116391012805	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391012806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391012807	Walker A/P-loop; other site
1116391012808	ATP binding site [chemical binding]; other site
1116391012809	Q-loop/lid; other site
1116391012810	ABC transporter signature motif; other site
1116391012811	Walker B; other site
1116391012812	D-loop; other site
1116391012813	H-loop/switch region; other site
1116391012814	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391012815	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391012816	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391012817	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1116391012818	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391012819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012820	dimer interface [polypeptide binding]; other site
1116391012821	conserved gate region; other site
1116391012822	putative PBP binding loops; other site
1116391012823	ABC-ATPase subunit interface; other site
1116391012824	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391012825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391012826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391012827	putative PBP binding loops; other site
1116391012828	dimer interface [polypeptide binding]; other site
1116391012829	ABC-ATPase subunit interface; other site
1116391012830	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391012831	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391012832	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391012833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012834	active site
1116391012835	phosphorylation site [posttranslational modification]
1116391012836	intermolecular recognition site; other site
1116391012837	dimerization interface [polypeptide binding]; other site
1116391012838	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012839	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012840	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012841	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391012842	HAMP domain; Region: HAMP; pfam00672
1116391012843	Histidine kinase; Region: His_kinase; pfam06580
1116391012844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391012845	ATP binding site [chemical binding]; other site
1116391012846	Mg2+ binding site [ion binding]; other site
1116391012847	G-X-G motif; other site
1116391012848	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1116391012849	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1116391012850	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1116391012851	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391012852	active site
1116391012853	Transposase domain (DUF772); Region: DUF772; pfam05598
1116391012854	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391012855	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391012856	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1116391012857	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1116391012858	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391012859	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391012860	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391012861	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391012862	DNA-binding site [nucleotide binding]; DNA binding site
1116391012863	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391012864	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391012865	homodimer interface [polypeptide binding]; other site
1116391012866	catalytic residue [active]
1116391012867	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391012868	EamA-like transporter family; Region: EamA; pfam00892
1116391012869	EamA-like transporter family; Region: EamA; pfam00892
1116391012870	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1116391012871	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1116391012872	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1116391012873	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1116391012874	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1116391012875	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391012876	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391012877	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391012878	active site
1116391012879	catalytic tetrad [active]
1116391012880	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391012881	Spore germination protein; Region: Spore_permease; cl17796
1116391012882	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391012883	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391012884	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391012885	putative trimer interface [polypeptide binding]; other site
1116391012886	putative CoA binding site [chemical binding]; other site
1116391012887	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391012888	putative trimer interface [polypeptide binding]; other site
1116391012889	putative CoA binding site [chemical binding]; other site
1116391012890	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1116391012891	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1116391012892	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391012893	Walker A/P-loop; other site
1116391012894	ATP binding site [chemical binding]; other site
1116391012895	Q-loop/lid; other site
1116391012896	ABC transporter signature motif; other site
1116391012897	Walker B; other site
1116391012898	D-loop; other site
1116391012899	H-loop/switch region; other site
1116391012900	Condensation domain; Region: Condensation; pfam00668
1116391012901	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012902	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391012903	acyl-activating enzyme (AAE) consensus motif; other site
1116391012904	AMP binding site [chemical binding]; other site
1116391012905	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012906	Condensation domain; Region: Condensation; pfam00668
1116391012907	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012908	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391012909	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391012910	acyl-activating enzyme (AAE) consensus motif; other site
1116391012911	AMP binding site [chemical binding]; other site
1116391012912	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012913	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1116391012914	acyl-activating enzyme (AAE) consensus motif; other site
1116391012915	AMP binding site [chemical binding]; other site
1116391012916	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012917	Condensation domain; Region: Condensation; pfam00668
1116391012918	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012919	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391012920	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391012921	acyl-activating enzyme (AAE) consensus motif; other site
1116391012922	AMP binding site [chemical binding]; other site
1116391012923	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391012924	Condensation domain; Region: Condensation; pfam00668
1116391012925	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391012926	Condensation domain; Region: Condensation; pfam00668
1116391012927	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391012928	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391012929	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391012930	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1116391012931	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1116391012932	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1116391012933	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1116391012934	trimer interface [polypeptide binding]; other site
1116391012935	active site
1116391012936	substrate binding site [chemical binding]; other site
1116391012937	CoA binding site [chemical binding]; other site
1116391012938	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391012939	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1116391012940	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1116391012941	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1116391012942	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1116391012943	dimer interface [polypeptide binding]; other site
1116391012944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391012945	catalytic residue [active]
1116391012946	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391012947	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391012948	active site
1116391012949	phosphorylation site [posttranslational modification]
1116391012950	dimerization interface [polypeptide binding]; other site
1116391012951	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391012952	DNA binding site [nucleotide binding]
1116391012953	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1116391012954	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
1116391012955	NAD binding site [chemical binding]; other site
1116391012956	homotetramer interface [polypeptide binding]; other site
1116391012957	homodimer interface [polypeptide binding]; other site
1116391012958	substrate binding site [chemical binding]; other site
1116391012959	active site
1116391012960	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
1116391012961	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1116391012962	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
1116391012963	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
1116391012964	dimer interface [polypeptide binding]; other site
1116391012965	active site
1116391012966	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1116391012967	catalytic residues [active]
1116391012968	substrate binding site [chemical binding]; other site
1116391012969	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391012970	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1116391012971	active site
1116391012972	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391012973	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1116391012974	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391012975	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1116391012976	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391012977	Walker A/P-loop; other site
1116391012978	ATP binding site [chemical binding]; other site
1116391012979	Q-loop/lid; other site
1116391012980	ABC transporter signature motif; other site
1116391012981	Walker B; other site
1116391012982	D-loop; other site
1116391012983	H-loop/switch region; other site
1116391012984	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391012985	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391012986	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
1116391012987	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391012988	FeS/SAM binding site; other site
1116391012989	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1116391012990	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1116391012991	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1116391012992	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391012993	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1116391012994	substrate binding site [chemical binding]; other site
1116391012995	active site
1116391012996	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1116391012997	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391012998	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391012999	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1116391013000	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1116391013001	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1116391013002	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1116391013003	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1116391013004	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1116391013005	cyclase homology domain; Region: CHD; cd07302
1116391013006	nucleotidyl binding site; other site
1116391013007	metal binding site [ion binding]; metal-binding site
1116391013008	dimer interface [polypeptide binding]; other site
1116391013009	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1116391013010	cyclase homology domain; Region: CHD; cd07302
1116391013011	nucleotidyl binding site; other site
1116391013012	metal binding site [ion binding]; metal-binding site
1116391013013	dimer interface [polypeptide binding]; other site
1116391013014	Predicted ATPase [General function prediction only]; Region: COG3899
1116391013015	AAA ATPase domain; Region: AAA_16; pfam13191
1116391013016	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1116391013017	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1116391013018	sulfite reductase subunit beta; Provisional; Region: PRK13504
1116391013019	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1116391013020	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1116391013021	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
1116391013022	Flavodoxin; Region: Flavodoxin_1; pfam00258
1116391013023	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1116391013024	FAD binding pocket [chemical binding]; other site
1116391013025	FAD binding motif [chemical binding]; other site
1116391013026	catalytic residues [active]
1116391013027	NAD binding pocket [chemical binding]; other site
1116391013028	phosphate binding motif [ion binding]; other site
1116391013029	beta-alpha-beta structure motif; other site
1116391013030	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
1116391013031	Calx-beta domain; Region: Calx-beta; pfam03160
1116391013032	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
1116391013033	Calx-beta domain; Region: Calx-beta; cl02522
1116391013034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391013035	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1116391013036	Walker A motif; other site
1116391013037	ATP binding site [chemical binding]; other site
1116391013038	Walker B motif; other site
1116391013039	arginine finger; other site
1116391013040	UvrB/uvrC motif; Region: UVR; pfam02151
1116391013041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391013042	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1116391013043	Walker A motif; other site
1116391013044	ATP binding site [chemical binding]; other site
1116391013045	Walker B motif; other site
1116391013046	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1116391013047	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391013048	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391013049	CHASE3 domain; Region: CHASE3; cl05000
1116391013050	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391013051	dimerization interface [polypeptide binding]; other site
1116391013052	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391013053	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391013054	dimer interface [polypeptide binding]; other site
1116391013055	putative CheW interface [polypeptide binding]; other site
1116391013056	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013057	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1116391013058	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1116391013059	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391013060	HTH domain; Region: HTH_11; pfam08279
1116391013061	WYL domain; Region: WYL; pfam13280
1116391013062	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391013063	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391013064	Spore germination protein; Region: Spore_permease; cl17796
1116391013065	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391013066	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
1116391013067	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1116391013068	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1116391013069	Chromate transporter; Region: Chromate_transp; pfam02417
1116391013070	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1116391013071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391013072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391013073	dimer interface [polypeptide binding]; other site
1116391013074	phosphorylation site [posttranslational modification]
1116391013075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391013076	ATP binding site [chemical binding]; other site
1116391013077	Mg2+ binding site [ion binding]; other site
1116391013078	G-X-G motif; other site
1116391013079	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391013080	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391013081	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391013082	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391013083	acyl-activating enzyme (AAE) consensus motif; other site
1116391013084	AMP binding site [chemical binding]; other site
1116391013085	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013086	Condensation domain; Region: Condensation; pfam00668
1116391013087	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013088	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013089	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1116391013090	acyl-activating enzyme (AAE) consensus motif; other site
1116391013091	AMP binding site [chemical binding]; other site
1116391013092	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013093	Condensation domain; Region: Condensation; pfam00668
1116391013094	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013095	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391013096	Condensation domain; Region: Condensation; pfam00668
1116391013097	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013098	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013099	acyl-activating enzyme (AAE) consensus motif; other site
1116391013100	AMP binding site [chemical binding]; other site
1116391013101	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013102	Thioesterase domain; Region: Thioesterase; pfam00975
1116391013103	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013104	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013105	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391013106	acyl-activating enzyme (AAE) consensus motif; other site
1116391013107	AMP binding site [chemical binding]; other site
1116391013108	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013109	Condensation domain; Region: Condensation; pfam00668
1116391013110	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013111	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013112	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013113	acyl-activating enzyme (AAE) consensus motif; other site
1116391013114	AMP binding site [chemical binding]; other site
1116391013115	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013116	Condensation domain; Region: Condensation; pfam00668
1116391013117	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013118	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1116391013119	Condensation domain; Region: Condensation; pfam00668
1116391013120	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013121	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013122	acyl-activating enzyme (AAE) consensus motif; other site
1116391013123	AMP binding site [chemical binding]; other site
1116391013124	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013125	Condensation domain; Region: Condensation; pfam00668
1116391013126	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013127	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013128	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013129	acyl-activating enzyme (AAE) consensus motif; other site
1116391013130	AMP binding site [chemical binding]; other site
1116391013131	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013132	Condensation domain; Region: Condensation; pfam00668
1116391013133	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013134	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013135	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391013136	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391013137	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1116391013138	Walker A/P-loop; other site
1116391013139	ATP binding site [chemical binding]; other site
1116391013140	Q-loop/lid; other site
1116391013141	ABC transporter signature motif; other site
1116391013142	Walker B; other site
1116391013143	D-loop; other site
1116391013144	H-loop/switch region; other site
1116391013145	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1116391013146	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391013147	inhibitor-cofactor binding pocket; inhibition site
1116391013148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391013149	catalytic residue [active]
1116391013150	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1116391013151	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1116391013152	metal ion-dependent adhesion site (MIDAS); other site
1116391013153	MoxR-like ATPases [General function prediction only]; Region: COG0714
1116391013154	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1116391013155	Walker A motif; other site
1116391013156	ATP binding site [chemical binding]; other site
1116391013157	Walker B motif; other site
1116391013158	arginine finger; other site
1116391013159	SWIM zinc finger; Region: SWIM; pfam04434
1116391013160	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1116391013161	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1116391013162	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391013163	active site
1116391013164	ATP binding site [chemical binding]; other site
1116391013165	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1116391013166	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1116391013167	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1116391013168	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1116391013169	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391013170	FeS/SAM binding site; other site
1116391013171	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1116391013172	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1116391013173	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1116391013174	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1116391013175	CPxP  motif; other site
1116391013176	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1116391013177	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391013178	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391013179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391013180	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391013181	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391013182	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1116391013183	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013184	putative substrate translocation pore; other site
1116391013185	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
1116391013186	Phosphotransferase enzyme family; Region: APH; pfam01636
1116391013187	putative active site [active]
1116391013188	putative substrate binding site [chemical binding]; other site
1116391013189	ATP binding site [chemical binding]; other site
1116391013190	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1116391013191	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1116391013192	dimer interface [polypeptide binding]; other site
1116391013193	active site
1116391013194	aminoglycoside resistance protein; Provisional; Region: PRK13746
1116391013195	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1116391013196	active site
1116391013197	NTP binding site [chemical binding]; other site
1116391013198	metal binding triad [ion binding]; metal-binding site
1116391013199	antibiotic binding site [chemical binding]; other site
1116391013200	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1116391013201	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391013202	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391013203	S-adenosylmethionine binding site [chemical binding]; other site
1116391013204	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1116391013205	Cellulose binding domain; Region: CBM_3; pfam00942
1116391013206	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
1116391013207	hypothetical protein; Provisional; Region: PRK12378
1116391013208	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013209	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1116391013210	acyl-activating enzyme (AAE) consensus motif; other site
1116391013211	AMP binding site [chemical binding]; other site
1116391013212	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1116391013213	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391013214	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391013215	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1116391013216	putative dimerization interface [polypeptide binding]; other site
1116391013217	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1116391013218	Amidohydrolase; Region: Amidohydro_2; pfam04909
1116391013219	active site
1116391013220	Predicted metalloprotease [General function prediction only]; Region: COG2321
1116391013221	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1116391013222	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1116391013223	H+ Antiporter protein; Region: 2A0121; TIGR00900
1116391013224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013225	putative substrate translocation pore; other site
1116391013226	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
1116391013227	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1116391013228	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1116391013229	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1116391013230	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013231	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013232	acyl-activating enzyme (AAE) consensus motif; other site
1116391013233	AMP binding site [chemical binding]; other site
1116391013234	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013235	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1116391013236	active site
1116391013237	Condensation domain; Region: Condensation; pfam00668
1116391013238	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013239	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013240	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013241	acyl-activating enzyme (AAE) consensus motif; other site
1116391013242	AMP binding site [chemical binding]; other site
1116391013243	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013244	Condensation domain; Region: Condensation; pfam00668
1116391013245	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013246	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013247	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013248	acyl-activating enzyme (AAE) consensus motif; other site
1116391013249	AMP binding site [chemical binding]; other site
1116391013250	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013251	acyl-CoA synthetase; Validated; Region: PRK05850
1116391013252	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1116391013253	acyl-activating enzyme (AAE) consensus motif; other site
1116391013254	active site
1116391013255	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1116391013256	Condensation domain; Region: Condensation; pfam00668
1116391013257	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1116391013258	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1116391013259	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1116391013260	acyl-activating enzyme (AAE) consensus motif; other site
1116391013261	AMP binding site [chemical binding]; other site
1116391013262	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1116391013263	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391013264	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391013265	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391013266	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1116391013267	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
1116391013268	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
1116391013269	active site
1116391013270	Zn binding site [ion binding]; other site
1116391013271	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1116391013272	dimer interface [polypeptide binding]; other site
1116391013273	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391013274	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391013275	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1116391013276	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1116391013277	Class I aldolases; Region: Aldolase_Class_I; cl17187
1116391013278	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1116391013279	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1116391013280	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391013281	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1116391013282	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1116391013283	dimer interface [polypeptide binding]; other site
1116391013284	PYR/PP interface [polypeptide binding]; other site
1116391013285	TPP binding site [chemical binding]; other site
1116391013286	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391013287	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1116391013288	TPP-binding site [chemical binding]; other site
1116391013289	dimer interface [polypeptide binding]; other site
1116391013290	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1116391013291	Cache domain; Region: Cache_1; pfam02743
1116391013292	HAMP domain; Region: HAMP; pfam00672
1116391013293	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391013294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391013295	metal binding site [ion binding]; metal-binding site
1116391013296	active site
1116391013297	I-site; other site
1116391013298	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
1116391013299	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1116391013300	Part of AAA domain; Region: AAA_19; pfam13245
1116391013301	Family description; Region: UvrD_C_2; pfam13538
1116391013302	putative transporter; Provisional; Region: PRK11021
1116391013303	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391013304	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391013305	DNA-binding site [nucleotide binding]; DNA binding site
1116391013306	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391013307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391013308	homodimer interface [polypeptide binding]; other site
1116391013309	catalytic residue [active]
1116391013310	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013311	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1116391013312	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1116391013313	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013314	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
1116391013315	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1116391013316	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1116391013317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1116391013318	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1116391013319	Propionate catabolism activator; Region: PrpR_N; pfam06506
1116391013320	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1116391013321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391013322	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1116391013323	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1116391013324	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1116391013325	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1116391013326	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1116391013327	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
1116391013328	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391013329	Interdomain contacts; other site
1116391013330	Cytokine receptor motif; other site
1116391013331	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
1116391013332	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391013333	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391013334	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391013335	DNA binding site [nucleotide binding]
1116391013336	domain linker motif; other site
1116391013337	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391013338	dimerization interface [polypeptide binding]; other site
1116391013339	ligand binding site [chemical binding]; other site
1116391013340	tellurium resistance terB-like protein; Region: terB_like; cl11965
1116391013341	metal binding site [ion binding]; metal-binding site
1116391013342	Cytochrome P450; Region: p450; pfam00067
1116391013343	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391013344	DinB superfamily; Region: DinB_2; pfam12867
1116391013345	protoporphyrinogen oxidase; Provisional; Region: PRK12416
1116391013346	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391013347	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1116391013348	VanZ like family; Region: VanZ; cl01971
1116391013349	RDD family; Region: RDD; pfam06271
1116391013350	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1116391013351	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1116391013352	substrate binding site [chemical binding]; other site
1116391013353	catalytic residues [active]
1116391013354	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391013355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391013356	active site
1116391013357	phosphorylation site [posttranslational modification]
1116391013358	intermolecular recognition site; other site
1116391013359	dimerization interface [polypeptide binding]; other site
1116391013360	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391013361	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391013362	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1116391013363	dimerization interface [polypeptide binding]; other site
1116391013364	Histidine kinase; Region: His_kinase; pfam06580
1116391013365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391013366	ATP binding site [chemical binding]; other site
1116391013367	Mg2+ binding site [ion binding]; other site
1116391013368	G-X-G motif; other site
1116391013369	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391013370	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391013371	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391013372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013373	dimer interface [polypeptide binding]; other site
1116391013374	conserved gate region; other site
1116391013375	putative PBP binding loops; other site
1116391013376	ABC-ATPase subunit interface; other site
1116391013377	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391013378	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013379	dimer interface [polypeptide binding]; other site
1116391013380	conserved gate region; other site
1116391013381	putative PBP binding loops; other site
1116391013382	ABC-ATPase subunit interface; other site
1116391013383	Domain of unknown function (DUF4306); Region: DUF4306; pfam14154
1116391013384	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391013385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391013386	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391013387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013388	putative substrate translocation pore; other site
1116391013389	CutC family; Region: CutC; cl01218
1116391013390	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1116391013391	RNAase interaction site [polypeptide binding]; other site
1116391013392	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1116391013393	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
1116391013394	NAD binding site [chemical binding]; other site
1116391013395	dimer interface [polypeptide binding]; other site
1116391013396	substrate binding site [chemical binding]; other site
1116391013397	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391013398	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1116391013399	Nicotianamine synthase protein; Region: NAS; cl17658
1116391013400	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1116391013401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1116391013402	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1116391013403	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1116391013404	malonyl-CoA binding site [chemical binding]; other site
1116391013405	dimer interface [polypeptide binding]; other site
1116391013406	active site
1116391013407	product binding site; other site
1116391013408	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
1116391013409	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1116391013410	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1116391013411	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1116391013412	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1116391013413	[2Fe-2S] cluster binding site [ion binding]; other site
1116391013414	Mannitol repressor; Region: MtlR; cl11450
1116391013415	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1116391013416	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1116391013417	NADP binding site [chemical binding]; other site
1116391013418	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1116391013419	Phloem protein 2; Region: PP2; pfam14299
1116391013420	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1116391013421	Protein of unknown function (DUF975); Region: DUF975; cl10504
1116391013422	S-layer homology domain; Region: SLH; pfam00395
1116391013423	S-layer homology domain; Region: SLH; pfam00395
1116391013424	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1116391013425	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391013426	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391013427	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1116391013428	Spore germination protein; Region: Spore_permease; cl17796
1116391013429	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391013430	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391013431	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1116391013432	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1116391013433	active site
1116391013434	catalytic triad [active]
1116391013435	dimer interface [polypeptide binding]; other site
1116391013436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391013437	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391013438	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1116391013439	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391013440	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391013441	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1116391013442	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
1116391013443	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1116391013444	minor groove reading motif; other site
1116391013445	helix-hairpin-helix signature motif; other site
1116391013446	substrate binding pocket [chemical binding]; other site
1116391013447	active site
1116391013448	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1116391013449	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1116391013450	DNA binding site [nucleotide binding]
1116391013451	active site
1116391013452	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1116391013453	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1116391013454	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1116391013455	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1116391013456	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1116391013457	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
1116391013458	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391013459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013460	putative substrate translocation pore; other site
1116391013461	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1116391013462	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013463	heat shock protein 90; Provisional; Region: PRK05218
1116391013464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391013465	ATP binding site [chemical binding]; other site
1116391013466	Mg2+ binding site [ion binding]; other site
1116391013467	G-X-G motif; other site
1116391013468	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
1116391013469	substrate binding pocket [chemical binding]; other site
1116391013470	substrate-Mg2+ binding site; other site
1116391013471	aspartate-rich region 1; other site
1116391013472	aspartate-rich region 2; other site
1116391013473	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1116391013474	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1116391013475	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1116391013476	short chain dehydrogenase; Provisional; Region: PRK07062
1116391013477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391013478	NAD(P) binding site [chemical binding]; other site
1116391013479	active site
1116391013480	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1116391013481	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1116391013482	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1116391013483	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1116391013484	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1116391013485	phosphopentomutase; Provisional; Region: PRK05362
1116391013486	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1116391013487	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1116391013488	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1116391013489	Nucleoside recognition; Region: Gate; pfam07670
1116391013490	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1116391013491	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1116391013492	active site
1116391013493	catalytic motif [active]
1116391013494	Zn binding site [ion binding]; other site
1116391013495	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1116391013496	intersubunit interface [polypeptide binding]; other site
1116391013497	active site
1116391013498	catalytic residue [active]
1116391013499	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1116391013500	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
1116391013501	non-specific DNA interactions [nucleotide binding]; other site
1116391013502	DNA binding site [nucleotide binding]
1116391013503	sequence specific DNA binding site [nucleotide binding]; other site
1116391013504	putative cAMP binding site [chemical binding]; other site
1116391013505	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1116391013506	DNA polymerase III subunit beta; Validated; Region: PRK05643
1116391013507	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1116391013508	putative DNA binding surface [nucleotide binding]; other site
1116391013509	dimer interface [polypeptide binding]; other site
1116391013510	beta-clamp/clamp loader binding surface; other site
1116391013511	beta-clamp/translesion DNA polymerase binding surface; other site
1116391013512	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1116391013513	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1116391013514	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1116391013515	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1116391013516	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1116391013517	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1116391013518	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1116391013519	dimer interface [polypeptide binding]; other site
1116391013520	FMN binding site [chemical binding]; other site
1116391013521	Rrf2 family protein; Region: rrf2_super; TIGR00738
1116391013522	Transcriptional regulator; Region: Rrf2; pfam02082
1116391013523	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1116391013524	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391013525	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1116391013526	substrate binding site [chemical binding]; other site
1116391013527	active site
1116391013528	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1116391013529	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1116391013530	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391013531	Phytochelatin synthase; Region: Phytochelatin; pfam05023
1116391013532	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013533	dimer interface [polypeptide binding]; other site
1116391013534	conserved gate region; other site
1116391013535	putative PBP binding loops; other site
1116391013536	ABC-ATPase subunit interface; other site
1116391013537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013538	dimer interface [polypeptide binding]; other site
1116391013539	conserved gate region; other site
1116391013540	ABC-ATPase subunit interface; other site
1116391013541	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391013542	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391013543	Predicted transcriptional regulator [Transcription]; Region: COG4189
1116391013544	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391013545	dimerization interface [polypeptide binding]; other site
1116391013546	putative DNA binding site [nucleotide binding]; other site
1116391013547	putative Zn2+ binding site [ion binding]; other site
1116391013548	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391013549	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391013550	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391013551	active site
1116391013552	catalytic triad [active]
1116391013553	ParB-like nuclease domain; Region: ParBc; pfam02195
1116391013554	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391013555	PAS domain; Region: PAS_9; pfam13426
1116391013556	putative active site [active]
1116391013557	heme pocket [chemical binding]; other site
1116391013558	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391013559	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1116391013560	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391013561	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391013562	Interdomain contacts; other site
1116391013563	Cytokine receptor motif; other site
1116391013564	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1116391013565	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1116391013566	Moco binding site; other site
1116391013567	metal coordination site [ion binding]; other site
1116391013568	YolD-like protein; Region: YolD; pfam08863
1116391013569	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1116391013570	dimer interface [polypeptide binding]; other site
1116391013571	[2Fe-2S] cluster binding site [ion binding]; other site
1116391013572	sugar efflux transporter; Region: 2A0120; TIGR00899
1116391013573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013574	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391013575	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391013576	ligand binding site [chemical binding]; other site
1116391013577	flexible hinge region; other site
1116391013578	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1116391013579	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1116391013580	DoxX-like family; Region: DoxX_3; pfam13781
1116391013581	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391013582	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1116391013583	DNA binding residues [nucleotide binding]
1116391013584	putative dimer interface [polypeptide binding]; other site
1116391013585	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391013586	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391013587	catalytic residues [active]
1116391013588	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1116391013589	Domain of unknown function DUF21; Region: DUF21; pfam01595
1116391013590	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1116391013591	Transporter associated domain; Region: CorC_HlyC; smart01091
1116391013592	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1116391013593	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391013594	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391013595	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1116391013596	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013597	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1116391013598	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391013599	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391013600	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013601	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391013602	putative substrate translocation pore; other site
1116391013603	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013604	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391013605	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391013606	protein binding site [polypeptide binding]; other site
1116391013607	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391013608	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1116391013609	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1116391013610	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391013611	NAD(P) binding site [chemical binding]; other site
1116391013612	active site
1116391013613	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1116391013614	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1116391013615	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1116391013616	active site
1116391013617	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391013618	S-adenosylmethionine binding site [chemical binding]; other site
1116391013619	putative phosphoesterase; Region: acc_ester; TIGR03729
1116391013620	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391013621	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1116391013622	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
1116391013623	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1116391013624	Nitronate monooxygenase; Region: NMO; pfam03060
1116391013625	FMN binding site [chemical binding]; other site
1116391013626	substrate binding site [chemical binding]; other site
1116391013627	putative catalytic residue [active]
1116391013628	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391013629	Coenzyme A binding pocket [chemical binding]; other site
1116391013630	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013631	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
1116391013632	S-layer homology domain; Region: SLH; pfam00395
1116391013633	S-layer homology domain; Region: SLH; pfam00395
1116391013634	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1116391013635	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1116391013636	protein binding site [polypeptide binding]; other site
1116391013637	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1116391013638	Active site serine [active]
1116391013639	Bacterial Ig-like domain; Region: Big_5; pfam13205
1116391013640	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391013641	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1116391013642	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391013643	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391013644	Walker A/P-loop; other site
1116391013645	ATP binding site [chemical binding]; other site
1116391013646	Q-loop/lid; other site
1116391013647	ABC transporter signature motif; other site
1116391013648	Walker B; other site
1116391013649	D-loop; other site
1116391013650	H-loop/switch region; other site
1116391013651	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391013652	Coenzyme A binding pocket [chemical binding]; other site
1116391013653	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1116391013654	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1116391013655	anti sigma factor interaction site; other site
1116391013656	regulatory phosphorylation site [posttranslational modification]; other site
1116391013657	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1116391013658	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391013659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391013660	active site
1116391013661	phosphorylation site [posttranslational modification]
1116391013662	intermolecular recognition site; other site
1116391013663	dimerization interface [polypeptide binding]; other site
1116391013664	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1116391013665	VPS10 domain; Region: VPS10; smart00602
1116391013666	VPS10 domain; Region: VPS10; smart00602
1116391013667	BNR repeat-like domain; Region: BNR_2; pfam13088
1116391013668	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
1116391013669	FAD dependent oxidoreductase; Region: DAO; pfam01266
1116391013670	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1116391013671	DNA-binding site [nucleotide binding]; DNA binding site
1116391013672	RNA-binding motif; other site
1116391013673	Rhomboid family; Region: Rhomboid; pfam01694
1116391013674	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1116391013675	Coat F domain; Region: Coat_F; pfam07875
1116391013676	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391013677	active site
1116391013678	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391013679	catalytic tetrad [active]
1116391013680	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1116391013681	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391013682	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391013683	Ion channel; Region: Ion_trans_2; pfam07885
1116391013684	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1116391013685	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1116391013686	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391013687	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1116391013688	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391013689	Walker A/P-loop; other site
1116391013690	ATP binding site [chemical binding]; other site
1116391013691	Q-loop/lid; other site
1116391013692	ABC transporter signature motif; other site
1116391013693	Walker B; other site
1116391013694	D-loop; other site
1116391013695	H-loop/switch region; other site
1116391013696	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391013697	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1116391013698	Walker A/P-loop; other site
1116391013699	ATP binding site [chemical binding]; other site
1116391013700	Q-loop/lid; other site
1116391013701	ABC transporter signature motif; other site
1116391013702	Walker B; other site
1116391013703	D-loop; other site
1116391013704	H-loop/switch region; other site
1116391013705	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391013706	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1116391013707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013708	dimer interface [polypeptide binding]; other site
1116391013709	conserved gate region; other site
1116391013710	putative PBP binding loops; other site
1116391013711	ABC-ATPase subunit interface; other site
1116391013712	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391013713	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013714	dimer interface [polypeptide binding]; other site
1116391013715	conserved gate region; other site
1116391013716	putative PBP binding loops; other site
1116391013717	ABC-ATPase subunit interface; other site
1116391013718	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391013719	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1116391013720	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1116391013721	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1116391013722	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391013723	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391013724	Coenzyme A binding pocket [chemical binding]; other site
1116391013725	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1116391013726	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391013727	NAD binding site [chemical binding]; other site
1116391013728	catalytic Zn binding site [ion binding]; other site
1116391013729	structural Zn binding site [ion binding]; other site
1116391013730	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1116391013731	active site
1116391013732	catalytic residues [active]
1116391013733	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1116391013734	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391013735	putative sugar binding sites [chemical binding]; other site
1116391013736	Q-X-W motif; other site
1116391013737	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1116391013738	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1116391013739	substrate binding site [chemical binding]; other site
1116391013740	multimerization interface [polypeptide binding]; other site
1116391013741	ATP binding site [chemical binding]; other site
1116391013742	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391013743	Cytochrome P450; Region: p450; cl12078
1116391013744	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391013745	MarR family; Region: MarR; pfam01047
1116391013746	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391013747	Coenzyme A binding pocket [chemical binding]; other site
1116391013748	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391013749	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1116391013750	SpoVR like protein; Region: SpoVR; pfam04293
1116391013751	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1116391013752	metal ion-dependent adhesion site (MIDAS); other site
1116391013753	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1116391013754	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1116391013755	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
1116391013756	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391013757	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391013758	PAS domain S-box; Region: sensory_box; TIGR00229
1116391013759	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391013760	putative active site [active]
1116391013761	heme pocket [chemical binding]; other site
1116391013762	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391013763	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391013764	putative active site [active]
1116391013765	heme pocket [chemical binding]; other site
1116391013766	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391013767	dimer interface [polypeptide binding]; other site
1116391013768	phosphorylation site [posttranslational modification]
1116391013769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391013770	ATP binding site [chemical binding]; other site
1116391013771	Mg2+ binding site [ion binding]; other site
1116391013772	G-X-G motif; other site
1116391013773	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391013774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391013775	active site
1116391013776	phosphorylation site [posttranslational modification]
1116391013777	intermolecular recognition site; other site
1116391013778	dimerization interface [polypeptide binding]; other site
1116391013779	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1116391013780	nudix motif; other site
1116391013781	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1116391013782	putative dimer interface [polypeptide binding]; other site
1116391013783	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391013784	ligand binding site [chemical binding]; other site
1116391013785	Zn binding site [ion binding]; other site
1116391013786	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1116391013787	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1116391013788	metal ion-dependent adhesion site (MIDAS); other site
1116391013789	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1116391013790	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1116391013791	homodimer interface [polypeptide binding]; other site
1116391013792	substrate-cofactor binding pocket; other site
1116391013793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391013794	catalytic residue [active]
1116391013795	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1116391013796	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1116391013797	Substrate-binding site [chemical binding]; other site
1116391013798	Substrate specificity [chemical binding]; other site
1116391013799	CHASE3 domain; Region: CHASE3; pfam05227
1116391013800	PAS fold; Region: PAS_4; pfam08448
1116391013801	PAS domain S-box; Region: sensory_box; TIGR00229
1116391013802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391013803	putative active site [active]
1116391013804	heme pocket [chemical binding]; other site
1116391013805	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391013806	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391013807	metal binding site [ion binding]; metal-binding site
1116391013808	active site
1116391013809	I-site; other site
1116391013810	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391013811	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1116391013812	catalytic triad [active]
1116391013813	conserved cis-peptide bond; other site
1116391013814	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1116391013815	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1116391013816	peptide binding site [polypeptide binding]; other site
1116391013817	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1116391013818	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1116391013819	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1116391013820	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391013821	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1116391013822	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1116391013823	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391013824	Coenzyme A binding pocket [chemical binding]; other site
1116391013825	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1116391013826	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391013827	Cytochrome P450; Region: p450; cl12078
1116391013828	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1116391013829	putative transporter; Provisional; Region: PRK11660
1116391013830	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1116391013831	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1116391013832	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1116391013833	active site clefts [active]
1116391013834	zinc binding site [ion binding]; other site
1116391013835	dimer interface [polypeptide binding]; other site
1116391013836	Isochorismatase family; Region: Isochorismatase; pfam00857
1116391013837	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1116391013838	catalytic triad [active]
1116391013839	conserved cis-peptide bond; other site
1116391013840	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
1116391013841	GIY-YIG motif/motif A; other site
1116391013842	Pectic acid lyase; Region: Pec_lyase; pfam09492
1116391013843	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1116391013844	hypothetical protein; Provisional; Region: PRK13660
1116391013845	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391013846	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391013847	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391013848	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1116391013849	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391013850	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1116391013851	putative transporter; Provisional; Region: PRK11021
1116391013852	Biofilm formation and stress response factor; Region: BsmA; pfam10014
1116391013853	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1116391013854	Ligand Binding Site [chemical binding]; other site
1116391013855	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391013856	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391013857	DNA binding residues [nucleotide binding]
1116391013858	dimerization interface [polypeptide binding]; other site
1116391013859	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1116391013860	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1116391013861	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
1116391013862	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1116391013863	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391013864	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391013865	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1116391013866	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1116391013867	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391013868	putative active site [active]
1116391013869	putative metal binding site [ion binding]; other site
1116391013870	multidrug efflux protein; Reviewed; Region: PRK01766
1116391013871	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1116391013872	cation binding site [ion binding]; other site
1116391013873	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1116391013874	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391013875	Interdomain contacts; other site
1116391013876	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
1116391013877	active site
1116391013878	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391013879	non-specific DNA binding site [nucleotide binding]; other site
1116391013880	salt bridge; other site
1116391013881	sequence-specific DNA binding site [nucleotide binding]; other site
1116391013882	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1116391013883	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1116391013884	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013885	dimer interface [polypeptide binding]; other site
1116391013886	conserved gate region; other site
1116391013887	putative PBP binding loops; other site
1116391013888	ABC-ATPase subunit interface; other site
1116391013889	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391013890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391013891	dimer interface [polypeptide binding]; other site
1116391013892	conserved gate region; other site
1116391013893	putative PBP binding loops; other site
1116391013894	ABC-ATPase subunit interface; other site
1116391013895	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391013896	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
1116391013897	peptide binding site [polypeptide binding]; other site
1116391013898	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1116391013899	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391013900	Walker A/P-loop; other site
1116391013901	ATP binding site [chemical binding]; other site
1116391013902	Q-loop/lid; other site
1116391013903	ABC transporter signature motif; other site
1116391013904	Walker B; other site
1116391013905	D-loop; other site
1116391013906	H-loop/switch region; other site
1116391013907	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391013908	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391013909	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391013910	Walker A/P-loop; other site
1116391013911	ATP binding site [chemical binding]; other site
1116391013912	Q-loop/lid; other site
1116391013913	ABC transporter signature motif; other site
1116391013914	Walker B; other site
1116391013915	D-loop; other site
1116391013916	H-loop/switch region; other site
1116391013917	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391013918	Phytase; Region: Phytase; cl17685
1116391013919	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1116391013920	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1116391013921	NodB motif; other site
1116391013922	active site
1116391013923	catalytic site [active]
1116391013924	Cd binding site [ion binding]; other site
1116391013925	Predicted ATPase [General function prediction only]; Region: COG3910
1116391013926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391013927	Walker A/P-loop; other site
1116391013928	ATP binding site [chemical binding]; other site
1116391013929	Q-loop/lid; other site
1116391013930	ABC transporter signature motif; other site
1116391013931	Walker B; other site
1116391013932	D-loop; other site
1116391013933	H-loop/switch region; other site
1116391013934	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
1116391013935	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1116391013936	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1116391013937	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391013938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391013939	dimer interface [polypeptide binding]; other site
1116391013940	phosphorylation site [posttranslational modification]
1116391013941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391013942	ATP binding site [chemical binding]; other site
1116391013943	Mg2+ binding site [ion binding]; other site
1116391013944	G-X-G motif; other site
1116391013945	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1116391013946	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1116391013947	Walker A/P-loop; other site
1116391013948	ATP binding site [chemical binding]; other site
1116391013949	Q-loop/lid; other site
1116391013950	ABC transporter signature motif; other site
1116391013951	Walker B; other site
1116391013952	D-loop; other site
1116391013953	H-loop/switch region; other site
1116391013954	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1116391013955	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391013956	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1116391013957	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391013958	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391013959	active site
1116391013960	catalytic tetrad [active]
1116391013961	metal-dependent hydrolase; Provisional; Region: PRK13291
1116391013962	DinB superfamily; Region: DinB_2; pfam12867
1116391013963	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1116391013964	hydrophobic ligand binding site; other site
1116391013965	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391013966	dimerization interface [polypeptide binding]; other site
1116391013967	putative DNA binding site [nucleotide binding]; other site
1116391013968	putative Zn2+ binding site [ion binding]; other site
1116391013969	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391013970	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1116391013971	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1116391013972	putative FMN binding site [chemical binding]; other site
1116391013973	S-layer homology domain; Region: SLH; pfam00395
1116391013974	S-layer homology domain; Region: SLH; pfam00395
1116391013975	S-layer homology domain; Region: SLH; pfam00395
1116391013976	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1116391013977	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391013978	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1116391013979	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1116391013980	ligand binding site [chemical binding]; other site
1116391013981	metal binding site [ion binding]; metal-binding site
1116391013982	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391013983	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1116391013984	DNA binding residues [nucleotide binding]
1116391013985	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1116391013986	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1116391013987	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391013988	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391013989	DNA binding residues [nucleotide binding]
1116391013990	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1116391013991	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391013992	TAP-like protein; Region: Abhydrolase_4; pfam08386
1116391013993	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
1116391013994	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1116391013995	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1116391013996	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391013997	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391013998	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391013999	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1116391014000	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1116391014001	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1116391014002	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391014003	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1116391014004	ABC transporter; Region: ABC_tran_2; pfam12848
1116391014005	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1116391014006	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1116391014007	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1116391014008	CoenzymeA binding site [chemical binding]; other site
1116391014009	subunit interaction site [polypeptide binding]; other site
1116391014010	PHB binding site; other site
1116391014011	Predicted transcriptional regulator [Transcription]; Region: COG1959
1116391014012	Transcriptional regulator; Region: Rrf2; pfam02082
1116391014013	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391014014	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391014015	Interdomain contacts; other site
1116391014016	Cytokine receptor motif; other site
1116391014017	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1116391014018	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391014019	TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF9; cl17378
1116391014020	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014022	dimer interface [polypeptide binding]; other site
1116391014023	conserved gate region; other site
1116391014024	putative PBP binding loops; other site
1116391014025	ABC-ATPase subunit interface; other site
1116391014026	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391014027	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014028	dimer interface [polypeptide binding]; other site
1116391014029	conserved gate region; other site
1116391014030	putative PBP binding loops; other site
1116391014031	ABC-ATPase subunit interface; other site
1116391014032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014033	active site
1116391014034	phosphorylation site [posttranslational modification]
1116391014035	intermolecular recognition site; other site
1116391014036	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014037	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391014038	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014039	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1116391014040	pentamer interface [polypeptide binding]; other site
1116391014041	dodecaamer interface [polypeptide binding]; other site
1116391014042	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
1116391014043	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391014044	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391014045	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1116391014046	substrate binding site [chemical binding]; other site
1116391014047	catalytic residues [active]
1116391014048	S-layer homology domain; Region: SLH; pfam00395
1116391014049	S-layer homology domain; Region: SLH; pfam00395
1116391014050	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1116391014051	Cytochrome P450; Region: p450; cl12078
1116391014052	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391014053	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391014054	DNA interaction; other site
1116391014055	Metal-binding active site; metal-binding site
1116391014056	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014058	dimer interface [polypeptide binding]; other site
1116391014059	conserved gate region; other site
1116391014060	putative PBP binding loops; other site
1116391014061	ABC-ATPase subunit interface; other site
1116391014062	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391014063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014064	dimer interface [polypeptide binding]; other site
1116391014065	conserved gate region; other site
1116391014066	ABC-ATPase subunit interface; other site
1116391014067	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391014068	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391014069	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391014070	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014071	Coat F domain; Region: Coat_F; cl17715
1116391014072	Protein of unknown function (DUF4025); Region: DUF4025; pfam13217
1116391014073	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1116391014074	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1116391014075	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1116391014076	homodimer interface [polypeptide binding]; other site
1116391014077	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1116391014078	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1116391014079	active site
1116391014080	homodimer interface [polypeptide binding]; other site
1116391014081	catalytic site [active]
1116391014082	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391014083	Interdomain contacts; other site
1116391014084	Cytokine receptor motif; other site
1116391014085	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1116391014086	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1116391014087	S-layer homology domain; Region: SLH; pfam00395
1116391014088	S-layer homology domain; Region: SLH; pfam00395
1116391014089	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391014090	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391014091	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391014092	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1116391014093	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1116391014094	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1116391014095	active site
1116391014096	DNA binding site [nucleotide binding]
1116391014097	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1116391014098	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1116391014099	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1116391014100	putative DNA binding site [nucleotide binding]; other site
1116391014101	putative homodimer interface [polypeptide binding]; other site
1116391014102	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391014103	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391014104	active site
1116391014105	catalytic tetrad [active]
1116391014106	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1116391014107	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1116391014108	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
1116391014109	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391014110	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014111	dimerization interface [polypeptide binding]; other site
1116391014112	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014113	dimerization interface [polypeptide binding]; other site
1116391014114	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391014115	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014116	dimerization interface [polypeptide binding]; other site
1116391014117	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014118	dimerization interface [polypeptide binding]; other site
1116391014119	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
1116391014120	dimerization interface [polypeptide binding]; other site
1116391014121	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014122	dimerization interface [polypeptide binding]; other site
1116391014123	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014124	dimerization interface [polypeptide binding]; other site
1116391014125	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014126	dimerization interface [polypeptide binding]; other site
1116391014127	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1116391014128	GAF domain; Region: GAF; pfam01590
1116391014129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391014130	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1116391014131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391014132	ATP binding site [chemical binding]; other site
1116391014133	Mg2+ binding site [ion binding]; other site
1116391014134	G-X-G motif; other site
1116391014135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014136	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391014137	active site
1116391014138	phosphorylation site [posttranslational modification]
1116391014139	intermolecular recognition site; other site
1116391014140	dimerization interface [polypeptide binding]; other site
1116391014141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014142	active site
1116391014143	phosphorylation site [posttranslational modification]
1116391014144	intermolecular recognition site; other site
1116391014145	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1116391014146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014147	active site
1116391014148	phosphorylation site [posttranslational modification]
1116391014149	intermolecular recognition site; other site
1116391014150	dimerization interface [polypeptide binding]; other site
1116391014151	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1116391014152	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1116391014153	dimer interface [polypeptide binding]; other site
1116391014154	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391014155	catalytic residue [active]
1116391014156	Cache domain; Region: Cache_1; pfam02743
1116391014157	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391014158	dimerization interface [polypeptide binding]; other site
1116391014159	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391014160	dimer interface [polypeptide binding]; other site
1116391014161	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391014162	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391014163	dimer interface [polypeptide binding]; other site
1116391014164	putative CheW interface [polypeptide binding]; other site
1116391014165	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1116391014166	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1116391014167	active site
1116391014168	iron coordination sites [ion binding]; other site
1116391014169	substrate binding pocket [chemical binding]; other site
1116391014170	Predicted membrane protein [Function unknown]; Region: COG2323
1116391014171	Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329
1116391014172	Spore germination protein; Region: Spore_permease; cl17796
1116391014173	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391014174	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391014175	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391014176	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1116391014177	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1116391014178	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1116391014179	NAD binding site [chemical binding]; other site
1116391014180	catalytic Zn binding site [ion binding]; other site
1116391014181	structural Zn binding site [ion binding]; other site
1116391014182	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1116391014183	active site
1116391014184	DNA binding site [nucleotide binding]
1116391014185	Rhomboid family; Region: Rhomboid; pfam01694
1116391014186	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391014187	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391014188	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1116391014189	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1116391014190	dimer interface [polypeptide binding]; other site
1116391014191	catalytic triad [active]
1116391014192	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1116391014193	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1116391014194	peptide binding site [polypeptide binding]; other site
1116391014195	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391014196	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391014197	Walker A/P-loop; other site
1116391014198	ATP binding site [chemical binding]; other site
1116391014199	Q-loop/lid; other site
1116391014200	ABC transporter signature motif; other site
1116391014201	Walker B; other site
1116391014202	D-loop; other site
1116391014203	H-loop/switch region; other site
1116391014204	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391014205	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1116391014206	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014207	dimer interface [polypeptide binding]; other site
1116391014208	conserved gate region; other site
1116391014209	putative PBP binding loops; other site
1116391014210	ABC-ATPase subunit interface; other site
1116391014211	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391014212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014213	dimer interface [polypeptide binding]; other site
1116391014214	conserved gate region; other site
1116391014215	putative PBP binding loops; other site
1116391014216	ABC-ATPase subunit interface; other site
1116391014217	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
1116391014218	SxDxEG motif; other site
1116391014219	active site
1116391014220	metal binding site [ion binding]; metal-binding site
1116391014221	homopentamer interface [polypeptide binding]; other site
1116391014222	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391014223	Interdomain contacts; other site
1116391014224	Cytokine receptor motif; other site
1116391014225	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391014226	Interdomain contacts; other site
1116391014227	Cytokine receptor motif; other site
1116391014228	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391014229	dockerin binding interface; other site
1116391014230	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1116391014231	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391014232	metal binding site [ion binding]; metal-binding site
1116391014233	active site
1116391014234	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391014235	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391014236	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014238	dimer interface [polypeptide binding]; other site
1116391014239	conserved gate region; other site
1116391014240	putative PBP binding loops; other site
1116391014241	ABC-ATPase subunit interface; other site
1116391014242	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391014243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014244	dimer interface [polypeptide binding]; other site
1116391014245	conserved gate region; other site
1116391014246	putative PBP binding loops; other site
1116391014247	ABC-ATPase subunit interface; other site
1116391014248	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391014249	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014250	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391014251	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391014252	active site
1116391014253	catalytic triad [active]
1116391014254	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391014255	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
1116391014256	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014258	dimer interface [polypeptide binding]; other site
1116391014259	conserved gate region; other site
1116391014260	putative PBP binding loops; other site
1116391014261	ABC-ATPase subunit interface; other site
1116391014262	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014264	dimer interface [polypeptide binding]; other site
1116391014265	conserved gate region; other site
1116391014266	putative PBP binding loops; other site
1116391014267	ABC-ATPase subunit interface; other site
1116391014268	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1116391014269	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391014270	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391014271	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391014272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014273	active site
1116391014274	phosphorylation site [posttranslational modification]
1116391014275	intermolecular recognition site; other site
1116391014276	dimerization interface [polypeptide binding]; other site
1116391014277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014278	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391014279	HAMP domain; Region: HAMP; pfam00672
1116391014280	dimerization interface [polypeptide binding]; other site
1116391014281	Histidine kinase; Region: His_kinase; pfam06580
1116391014282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391014283	ATP binding site [chemical binding]; other site
1116391014284	Mg2+ binding site [ion binding]; other site
1116391014285	G-X-G motif; other site
1116391014286	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391014287	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1116391014288	active site
1116391014289	motif I; other site
1116391014290	motif II; other site
1116391014291	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1116391014292	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1116391014293	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1116391014294	nudix motif; other site
1116391014295	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391014296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391014297	Coenzyme A binding pocket [chemical binding]; other site
1116391014298	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1116391014299	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1116391014300	E-class dimer interface [polypeptide binding]; other site
1116391014301	P-class dimer interface [polypeptide binding]; other site
1116391014302	active site
1116391014303	Cu2+ binding site [ion binding]; other site
1116391014304	Zn2+ binding site [ion binding]; other site
1116391014305	Protein of unknown function (DUF4023); Region: DUF4023; pfam13215
1116391014306	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1116391014307	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1116391014308	Predicted membrane protein [Function unknown]; Region: COG2323
1116391014309	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1116391014310	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1116391014311	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1116391014312	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1116391014313	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1116391014314	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
1116391014315	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1116391014316	NAD binding site [chemical binding]; other site
1116391014317	Phe binding site; other site
1116391014318	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391014319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391014320	S-adenosylmethionine binding site [chemical binding]; other site
1116391014321	Predicted membrane protein [Function unknown]; Region: COG4129
1116391014322	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1116391014323	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1116391014324	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1116391014325	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1116391014326	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1116391014327	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1116391014328	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1116391014329	dimer interface [polypeptide binding]; other site
1116391014330	active site
1116391014331	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391014332	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1116391014333	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1116391014334	active site
1116391014335	Isochorismatase family; Region: Isochorismatase; pfam00857
1116391014336	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1116391014337	catalytic triad [active]
1116391014338	conserved cis-peptide bond; other site
1116391014339	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1116391014340	Part of AAA domain; Region: AAA_19; pfam13245
1116391014341	Family description; Region: UvrD_C_2; pfam13538
1116391014342	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391014343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391014344	Coenzyme A binding pocket [chemical binding]; other site
1116391014345	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391014346	Coenzyme A binding pocket [chemical binding]; other site
1116391014347	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391014348	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1116391014349	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391014350	Coenzyme A binding pocket [chemical binding]; other site
1116391014351	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1116391014352	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1116391014353	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391014354	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
1116391014355	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
1116391014356	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391014357	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391014358	Walker A/P-loop; other site
1116391014359	ATP binding site [chemical binding]; other site
1116391014360	Q-loop/lid; other site
1116391014361	ABC transporter signature motif; other site
1116391014362	Walker B; other site
1116391014363	D-loop; other site
1116391014364	H-loop/switch region; other site
1116391014365	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
1116391014366	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1116391014367	active site
1116391014368	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1116391014369	Putative esterase; Region: Esterase; pfam00756
1116391014370	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391014371	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391014372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014373	active site
1116391014374	phosphorylation site [posttranslational modification]
1116391014375	intermolecular recognition site; other site
1116391014376	dimerization interface [polypeptide binding]; other site
1116391014377	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391014378	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014379	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391014380	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1116391014381	dimerization interface [polypeptide binding]; other site
1116391014382	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391014383	Histidine kinase; Region: His_kinase; pfam06580
1116391014384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391014385	ATP binding site [chemical binding]; other site
1116391014386	Mg2+ binding site [ion binding]; other site
1116391014387	G-X-G motif; other site
1116391014388	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391014389	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391014390	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014392	dimer interface [polypeptide binding]; other site
1116391014393	ABC-ATPase subunit interface; other site
1116391014394	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391014395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014396	dimer interface [polypeptide binding]; other site
1116391014397	conserved gate region; other site
1116391014398	ABC-ATPase subunit interface; other site
1116391014399	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
1116391014400	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1116391014401	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391014402	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391014403	dimer interface [polypeptide binding]; other site
1116391014404	phosphorylation site [posttranslational modification]
1116391014405	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391014406	ATP binding site [chemical binding]; other site
1116391014407	Mg2+ binding site [ion binding]; other site
1116391014408	G-X-G motif; other site
1116391014409	VanZ like family; Region: VanZ; pfam04892
1116391014410	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391014411	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391014412	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391014413	Spore germination protein; Region: Spore_permease; cl17796
1116391014414	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1116391014415	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1116391014416	putative active site [active]
1116391014417	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1116391014418	dimer interface [polypeptide binding]; other site
1116391014419	active site
1116391014420	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1116391014421	active site
1116391014422	homotetramer interface [polypeptide binding]; other site
1116391014423	homodimer interface [polypeptide binding]; other site
1116391014424	fructoselysine 3-epimerase; Provisional; Region: PRK09856
1116391014425	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391014426	Metal-binding active site; metal-binding site
1116391014427	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391014428	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014429	dimer interface [polypeptide binding]; other site
1116391014430	conserved gate region; other site
1116391014431	putative PBP binding loops; other site
1116391014432	ABC-ATPase subunit interface; other site
1116391014433	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391014434	dimer interface [polypeptide binding]; other site
1116391014435	conserved gate region; other site
1116391014436	putative PBP binding loops; other site
1116391014437	ABC-ATPase subunit interface; other site
1116391014438	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391014439	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391014440	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391014441	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1116391014442	substrate binding site [chemical binding]; other site
1116391014443	ATP binding site [chemical binding]; other site
1116391014444	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
1116391014445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391014446	DNA-binding site [nucleotide binding]; DNA binding site
1116391014447	UTRA domain; Region: UTRA; pfam07702
1116391014448	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1116391014449	regulatory protein interface [polypeptide binding]; other site
1116391014450	regulatory phosphorylation site [posttranslational modification]; other site
1116391014451	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1116391014452	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
1116391014453	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1116391014454	Chromate transporter; Region: Chromate_transp; pfam02417
1116391014455	Chromate transporter; Region: Chromate_transp; pfam02417
1116391014456	YmaF family; Region: YmaF; pfam12788
1116391014457	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
1116391014458	YtkA-like; Region: YtkA; pfam13115
1116391014459	Family description; Region: DsbD_2; pfam13386
1116391014460	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1116391014461	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1116391014462	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1116391014463	nickel responsive regulator; Provisional; Region: PRK04460
1116391014464	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1116391014465	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1116391014466	Predicted membrane protein [Function unknown]; Region: COG4550
1116391014467	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327
1116391014468	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1116391014469	Predicted permease; Region: DUF318; cl17795
1116391014470	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391014471	FeS/SAM binding site; other site
1116391014472	TRAM domain; Region: TRAM; pfam01938
1116391014473	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1116391014474	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1116391014475	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1116391014476	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1116391014477	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1116391014478	TPP-binding site [chemical binding]; other site
1116391014479	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1116391014480	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1116391014481	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1116391014482	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1116391014483	dimer interface [polypeptide binding]; other site
1116391014484	PYR/PP interface [polypeptide binding]; other site
1116391014485	TPP binding site [chemical binding]; other site
1116391014486	substrate binding site [chemical binding]; other site
1116391014487	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1116391014488	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1116391014489	active site
1116391014490	dimer interface [polypeptide binding]; other site
1116391014491	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1116391014492	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1116391014493	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391014494	putative active site [active]
1116391014495	metal binding site [ion binding]; metal-binding site
1116391014496	homodimer binding site [polypeptide binding]; other site
1116391014497	phosphodiesterase; Provisional; Region: PRK12704
1116391014498	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391014499	Zn2+ binding site [ion binding]; other site
1116391014500	Mg2+ binding site [ion binding]; other site
1116391014501	RecX family; Region: RecX; cl00936
1116391014502	recombinase A; Provisional; Region: recA; PRK09354
1116391014503	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1116391014504	hexamer interface [polypeptide binding]; other site
1116391014505	Walker A motif; other site
1116391014506	ATP binding site [chemical binding]; other site
1116391014507	Walker B motif; other site
1116391014508	competence damage-inducible protein A; Provisional; Region: PRK00549
1116391014509	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1116391014510	putative MPT binding site; other site
1116391014511	Competence-damaged protein; Region: CinA; pfam02464
1116391014512	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1116391014513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1116391014514	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1116391014515	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1116391014516	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1116391014517	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1116391014518	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1116391014519	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391014520	non-specific DNA binding site [nucleotide binding]; other site
1116391014521	salt bridge; other site
1116391014522	sequence-specific DNA binding site [nucleotide binding]; other site
1116391014523	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1116391014524	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1116391014525	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1116391014526	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1116391014527	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391014528	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391014529	NAD(P) binding site [chemical binding]; other site
1116391014530	active site
1116391014531	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1116391014532	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1116391014533	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1116391014534	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1116391014535	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1116391014536	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1116391014537	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1116391014538	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1116391014539	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1116391014540	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1116391014541	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1116391014542	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1116391014543	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1116391014544	YlzJ-like protein; Region: YlzJ; pfam14035
1116391014545	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1116391014546	active site
1116391014547	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1116391014548	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391014549	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1116391014550	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1116391014551	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1116391014552	dimer interface [polypeptide binding]; other site
1116391014553	active site
1116391014554	catalytic residue [active]
1116391014555	aspartate kinase I; Reviewed; Region: PRK08210
1116391014556	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1116391014557	nucleotide binding site [chemical binding]; other site
1116391014558	substrate binding site [chemical binding]; other site
1116391014559	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1116391014560	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1116391014561	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1116391014562	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1116391014563	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1116391014564	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1116391014565	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1116391014566	NAD binding site [chemical binding]; other site
1116391014567	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1116391014568	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1116391014569	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1116391014570	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
1116391014571	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1116391014572	NodB motif; other site
1116391014573	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1116391014574	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1116391014575	RNase E interface [polypeptide binding]; other site
1116391014576	trimer interface [polypeptide binding]; other site
1116391014577	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1116391014578	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1116391014579	RNase E interface [polypeptide binding]; other site
1116391014580	trimer interface [polypeptide binding]; other site
1116391014581	active site
1116391014582	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1116391014583	putative nucleic acid binding region [nucleotide binding]; other site
1116391014584	G-X-X-G motif; other site
1116391014585	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1116391014586	RNA binding site [nucleotide binding]; other site
1116391014587	domain interface; other site
1116391014588	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1116391014589	16S/18S rRNA binding site [nucleotide binding]; other site
1116391014590	S13e-L30e interaction site [polypeptide binding]; other site
1116391014591	25S rRNA binding site [nucleotide binding]; other site
1116391014592	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1116391014593	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1116391014594	active site
1116391014595	Riboflavin kinase; Region: Flavokinase; pfam01687
1116391014596	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1116391014597	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1116391014598	RNA binding site [nucleotide binding]; other site
1116391014599	active site
1116391014600	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1116391014601	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1116391014602	DHH family; Region: DHH; pfam01368
1116391014603	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1116391014604	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1116391014605	translation initiation factor IF-2; Region: IF-2; TIGR00487
1116391014606	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1116391014607	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1116391014608	G1 box; other site
1116391014609	putative GEF interaction site [polypeptide binding]; other site
1116391014610	GTP/Mg2+ binding site [chemical binding]; other site
1116391014611	Switch I region; other site
1116391014612	G2 box; other site
1116391014613	G3 box; other site
1116391014614	Switch II region; other site
1116391014615	G4 box; other site
1116391014616	G5 box; other site
1116391014617	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1116391014618	Translation-initiation factor 2; Region: IF-2; pfam11987
1116391014619	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1116391014620	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1116391014621	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1116391014622	putative RNA binding cleft [nucleotide binding]; other site
1116391014623	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1116391014624	NusA N-terminal domain; Region: NusA_N; pfam08529
1116391014625	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1116391014626	RNA binding site [nucleotide binding]; other site
1116391014627	homodimer interface [polypeptide binding]; other site
1116391014628	NusA-like KH domain; Region: KH_5; pfam13184
1116391014629	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1116391014630	G-X-X-G motif; other site
1116391014631	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1116391014632	Sm and related proteins; Region: Sm_like; cl00259
1116391014633	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1116391014634	putative oligomer interface [polypeptide binding]; other site
1116391014635	putative RNA binding site [nucleotide binding]; other site
1116391014636	prolyl-tRNA synthetase; Provisional; Region: PRK08661
1116391014637	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
1116391014638	dimer interface [polypeptide binding]; other site
1116391014639	motif 1; other site
1116391014640	active site
1116391014641	motif 2; other site
1116391014642	motif 3; other site
1116391014643	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
1116391014644	anticodon binding site; other site
1116391014645	zinc-binding site [ion binding]; other site
1116391014646	RIP metalloprotease RseP; Region: TIGR00054
1116391014647	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1116391014648	active site
1116391014649	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1116391014650	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1116391014651	protein binding site [polypeptide binding]; other site
1116391014652	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1116391014653	putative substrate binding region [chemical binding]; other site
1116391014654	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1116391014655	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1116391014656	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1116391014657	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1116391014658	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1116391014659	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1116391014660	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
1116391014661	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1116391014662	catalytic residue [active]
1116391014663	putative FPP diphosphate  binding site; other site
1116391014664	putative FPP binding hydrophobic cleft; other site
1116391014665	dimer interface [polypeptide binding]; other site
1116391014666	putative IPP diphosphate binding site; other site
1116391014667	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1116391014668	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1116391014669	hinge region; other site
1116391014670	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1116391014671	putative nucleotide binding site [chemical binding]; other site
1116391014672	uridine monophosphate binding site [chemical binding]; other site
1116391014673	homohexameric interface [polypeptide binding]; other site
1116391014674	elongation factor Ts; Reviewed; Region: tsf; PRK12332
1116391014675	UBA/TS-N domain; Region: UBA; pfam00627
1116391014676	Elongation factor TS; Region: EF_TS; pfam00889
1116391014677	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1116391014678	rRNA interaction site [nucleotide binding]; other site
1116391014679	S8 interaction site; other site
1116391014680	putative laminin-1 binding site; other site
1116391014681	YceG-like family; Region: YceG; pfam02618
1116391014682	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1116391014683	heterogeneous nuclear ribonucleoprotein R, Q family; Region: hnRNP-R-Q; TIGR01648
1116391014684	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
1116391014685	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1116391014686	CheC-like family; Region: CheC; pfam04509
1116391014687	CheC-like family; Region: CheC; pfam04509
1116391014688	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1116391014689	putative CheA interaction surface; other site
1116391014690	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1116391014691	putative binding surface; other site
1116391014692	active site
1116391014693	P2 response regulator binding domain; Region: P2; pfam07194
1116391014694	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1116391014695	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1116391014696	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391014697	ATP binding site [chemical binding]; other site
1116391014698	Mg2+ binding site [ion binding]; other site
1116391014699	G-X-G motif; other site
1116391014700	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1116391014701	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1116391014702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014703	active site
1116391014704	phosphorylation site [posttranslational modification]
1116391014705	intermolecular recognition site; other site
1116391014706	dimerization interface [polypeptide binding]; other site
1116391014707	CheB methylesterase; Region: CheB_methylest; pfam01339
1116391014708	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1116391014709	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1116391014710	P-loop; other site
1116391014711	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
1116391014712	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
1116391014713	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1116391014714	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1116391014715	FHIPEP family; Region: FHIPEP; pfam00771
1116391014716	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1116391014717	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1116391014718	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1116391014719	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1116391014720	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1116391014721	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
1116391014722	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391014723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391014724	active site
1116391014725	phosphorylation site [posttranslational modification]
1116391014726	intermolecular recognition site; other site
1116391014727	dimerization interface [polypeptide binding]; other site
1116391014728	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1116391014729	CheC-like family; Region: CheC; pfam04509
1116391014730	CheC-like family; Region: CheC; pfam04509
1116391014731	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1116391014732	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1116391014733	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1116391014734	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
1116391014735	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1116391014736	Flagellar protein (FlbD); Region: FlbD; pfam06289
1116391014737	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
1116391014738	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1116391014739	Class I aldolases; Region: Aldolase_Class_I; cl17187
1116391014740	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1116391014741	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
1116391014742	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1116391014743	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1116391014744	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1116391014745	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
1116391014746	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
1116391014747	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
1116391014748	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1116391014749	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1116391014750	Walker A motif/ATP binding site; other site
1116391014751	Walker B motif; other site
1116391014752	flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825
1116391014753	Flagellar assembly protein FliH; Region: FliH; pfam02108
1116391014754	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1116391014755	FliG C-terminal domain; Region: FliG_C; pfam01706
1116391014756	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1116391014757	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1116391014758	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1116391014759	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
1116391014760	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1116391014761	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1116391014762	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1116391014763	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1116391014764	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1116391014765	transcriptional repressor CodY; Validated; Region: PRK04158
1116391014766	CodY GAF-like domain; Region: CodY; pfam06018
1116391014767	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1116391014768	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1116391014769	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1116391014770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391014771	Walker A motif; other site
1116391014772	ATP binding site [chemical binding]; other site
1116391014773	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1116391014774	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1116391014775	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1116391014776	active site
1116391014777	HslU subunit interaction site [polypeptide binding]; other site
1116391014778	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1116391014779	Glucose inhibited division protein A; Region: GIDA; pfam01134
1116391014780	DNA topoisomerase I; Validated; Region: PRK05582
1116391014781	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1116391014782	active site
1116391014783	interdomain interaction site; other site
1116391014784	putative metal-binding site [ion binding]; other site
1116391014785	nucleotide binding site [chemical binding]; other site
1116391014786	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1116391014787	domain I; other site
1116391014788	DNA binding groove [nucleotide binding]
1116391014789	phosphate binding site [ion binding]; other site
1116391014790	domain II; other site
1116391014791	domain III; other site
1116391014792	nucleotide binding site [chemical binding]; other site
1116391014793	catalytic site [active]
1116391014794	domain IV; other site
1116391014795	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1116391014796	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1116391014797	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1116391014798	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1116391014799	DNA protecting protein DprA; Region: dprA; TIGR00732
1116391014800	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1116391014801	CoA binding domain; Region: CoA_binding; smart00881
1116391014802	CoA-ligase; Region: Ligase_CoA; pfam00549
1116391014803	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1116391014804	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1116391014805	CoA-ligase; Region: Ligase_CoA; pfam00549
1116391014806	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1116391014807	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1116391014808	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391014809	Walker A motif; other site
1116391014810	ATP binding site [chemical binding]; other site
1116391014811	Walker B motif; other site
1116391014812	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1116391014813	hypothetical protein; Reviewed; Region: PRK12497
1116391014814	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1116391014815	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1116391014816	RNA/DNA hybrid binding site [nucleotide binding]; other site
1116391014817	active site
1116391014818	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1116391014819	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1116391014820	putative active site [active]
1116391014821	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1116391014822	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1116391014823	GTP/Mg2+ binding site [chemical binding]; other site
1116391014824	G4 box; other site
1116391014825	G5 box; other site
1116391014826	G1 box; other site
1116391014827	Switch I region; other site
1116391014828	G2 box; other site
1116391014829	G3 box; other site
1116391014830	Switch II region; other site
1116391014831	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1116391014832	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1116391014833	Catalytic site [active]
1116391014834	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
1116391014835	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1116391014836	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
1116391014837	S-layer homology domain; Region: SLH; pfam00395
1116391014838	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1116391014839	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1116391014840	RimM N-terminal domain; Region: RimM; pfam01782
1116391014841	PRC-barrel domain; Region: PRC; pfam05239
1116391014842	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1116391014843	hypothetical protein; Provisional; Region: PRK00468
1116391014844	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1116391014845	signal recognition particle protein; Provisional; Region: PRK10867
1116391014846	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1116391014847	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1116391014848	P loop; other site
1116391014849	GTP binding site [chemical binding]; other site
1116391014850	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1116391014851	putative DNA-binding protein; Validated; Region: PRK00118
1116391014852	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1116391014853	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1116391014854	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1116391014855	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1116391014856	P loop; other site
1116391014857	GTP binding site [chemical binding]; other site
1116391014858	ribonuclease III; Reviewed; Region: rnc; PRK00102
1116391014859	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1116391014860	dimerization interface [polypeptide binding]; other site
1116391014861	active site
1116391014862	metal binding site [ion binding]; metal-binding site
1116391014863	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1116391014864	dsRNA binding site [nucleotide binding]; other site
1116391014865	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1116391014866	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1116391014867	dimer interface [polypeptide binding]; other site
1116391014868	active site
1116391014869	acyl carrier protein; Provisional; Region: acpP; PRK00982
1116391014870	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391014871	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1116391014872	NAD(P) binding site [chemical binding]; other site
1116391014873	homotetramer interface [polypeptide binding]; other site
1116391014874	homodimer interface [polypeptide binding]; other site
1116391014875	active site
1116391014876	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1116391014877	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1116391014878	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1116391014879	dimer interface [polypeptide binding]; other site
1116391014880	active site
1116391014881	CoA binding pocket [chemical binding]; other site
1116391014882	putative phosphate acyltransferase; Provisional; Region: PRK05331
1116391014883	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1116391014884	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1116391014885	active site 2 [active]
1116391014886	active site 1 [active]
1116391014887	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1116391014888	hypothetical protein; Provisional; Region: PRK13670
1116391014889	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1116391014890	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1116391014891	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391014892	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1116391014893	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1116391014894	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1116391014895	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1116391014896	active site
1116391014897	(T/H)XGH motif; other site
1116391014898	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1116391014899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391014900	S-adenosylmethionine binding site [chemical binding]; other site
1116391014901	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391014902	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391014903	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1116391014904	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391014905	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391014906	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391014907	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
1116391014908	active site
1116391014909	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1116391014910	RDD family; Region: RDD; pfam06271
1116391014911	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1116391014912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391014913	putative metal binding site [ion binding]; other site
1116391014914	Predicted membrane protein [Function unknown]; Region: COG3766
1116391014915	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1116391014916	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1116391014917	Glucuronate isomerase; Region: UxaC; pfam02614
1116391014918	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1116391014919	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1116391014920	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1116391014921	Right handed beta helix region; Region: Beta_helix; pfam13229
1116391014922	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391014923	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391014924	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391014925	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1116391014926	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1116391014927	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1116391014928	generic binding surface II; other site
1116391014929	ssDNA binding site; other site
1116391014930	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391014931	ATP binding site [chemical binding]; other site
1116391014932	putative Mg++ binding site [ion binding]; other site
1116391014933	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391014934	nucleotide binding region [chemical binding]; other site
1116391014935	ATP-binding site [chemical binding]; other site
1116391014936	EDD domain protein, DegV family; Region: DegV; TIGR00762
1116391014937	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1116391014938	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1116391014939	DAK2 domain; Region: Dak2; pfam02734
1116391014940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1116391014941	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1116391014942	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
1116391014943	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1116391014944	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1116391014945	substrate binding site [chemical binding]; other site
1116391014946	hexamer interface [polypeptide binding]; other site
1116391014947	metal binding site [ion binding]; metal-binding site
1116391014948	GTPase RsgA; Reviewed; Region: PRK00098
1116391014949	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1116391014950	RNA binding site [nucleotide binding]; other site
1116391014951	homodimer interface [polypeptide binding]; other site
1116391014952	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1116391014953	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1116391014954	GTP/Mg2+ binding site [chemical binding]; other site
1116391014955	G4 box; other site
1116391014956	G5 box; other site
1116391014957	G1 box; other site
1116391014958	Switch I region; other site
1116391014959	G2 box; other site
1116391014960	G3 box; other site
1116391014961	Switch II region; other site
1116391014962	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1116391014963	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1116391014964	active site
1116391014965	ATP binding site [chemical binding]; other site
1116391014966	substrate binding site [chemical binding]; other site
1116391014967	activation loop (A-loop); other site
1116391014968	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1116391014969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1116391014970	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1116391014971	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1116391014972	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1116391014973	active site
1116391014974	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1116391014975	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391014976	FeS/SAM binding site; other site
1116391014977	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1116391014978	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1116391014979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391014980	S-adenosylmethionine binding site [chemical binding]; other site
1116391014981	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1116391014982	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1116391014983	putative active site [active]
1116391014984	substrate binding site [chemical binding]; other site
1116391014985	putative cosubstrate binding site; other site
1116391014986	catalytic site [active]
1116391014987	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1116391014988	substrate binding site [chemical binding]; other site
1116391014989	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1116391014990	active site
1116391014991	catalytic residues [active]
1116391014992	metal binding site [ion binding]; metal-binding site
1116391014993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391014994	primosomal protein N' Region: priA; TIGR00595
1116391014995	ATP binding site [chemical binding]; other site
1116391014996	putative Mg++ binding site [ion binding]; other site
1116391014997	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1116391014998	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1116391014999	Flavoprotein; Region: Flavoprotein; pfam02441
1116391015000	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1116391015001	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1116391015002	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1116391015003	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1116391015004	catalytic site [active]
1116391015005	G-X2-G-X-G-K; other site
1116391015006	hypothetical protein; Provisional; Region: PRK04323
1116391015007	hypothetical protein; Provisional; Region: PRK11820
1116391015008	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1116391015009	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1116391015010	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1116391015011	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1116391015012	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1116391015013	FAD binding site [chemical binding]; other site
1116391015014	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1116391015015	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1116391015016	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1116391015017	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1116391015018	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1116391015019	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1116391015020	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1116391015021	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391015022	motif II; other site
1116391015023	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1116391015024	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1116391015025	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1116391015026	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391015027	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1116391015028	DNA binding residues [nucleotide binding]
1116391015029	B12 binding domain; Region: B12-binding_2; pfam02607
1116391015030	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1116391015031	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
1116391015032	CheB methylesterase; Region: CheB_methylest; pfam01339
1116391015033	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1116391015034	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1116391015035	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1116391015036	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
1116391015037	PAS domain; Region: PAS_10; pfam13596
1116391015038	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391015039	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391015040	putative active site [active]
1116391015041	heme pocket [chemical binding]; other site
1116391015042	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391015043	dimer interface [polypeptide binding]; other site
1116391015044	phosphorylation site [posttranslational modification]
1116391015045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391015046	ATP binding site [chemical binding]; other site
1116391015047	Mg2+ binding site [ion binding]; other site
1116391015048	G-X-G motif; other site
1116391015049	B12 binding domain; Region: B12-binding_2; pfam02607
1116391015050	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
1116391015051	B12 binding site [chemical binding]; other site
1116391015052	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1116391015053	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1116391015054	active site
1116391015055	tetramer interface; other site
1116391015056	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1116391015057	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1116391015058	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1116391015059	putative dimerization interface [polypeptide binding]; other site
1116391015060	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
1116391015061	L-asparaginase II; Region: Asparaginase_II; pfam06089
1116391015062	Protein of unknown function (DUF964); Region: DUF964; cl01483
1116391015063	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1116391015064	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1116391015065	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1116391015066	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391015067	ATP binding site [chemical binding]; other site
1116391015068	putative Mg++ binding site [ion binding]; other site
1116391015069	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391015070	nucleotide binding region [chemical binding]; other site
1116391015071	ATP-binding site [chemical binding]; other site
1116391015072	Staphylococcal nuclease homologues; Region: SNc; smart00318
1116391015073	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1116391015074	Catalytic site; other site
1116391015075	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1116391015076	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1116391015077	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1116391015078	active site
1116391015079	HIGH motif; other site
1116391015080	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1116391015081	tRNA binding surface [nucleotide binding]; other site
1116391015082	anticodon binding site; other site
1116391015083	FOG: CBS domain [General function prediction only]; Region: COG0517
1116391015084	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1116391015085	YugN-like family; Region: YugN; pfam08868
1116391015086	cell division protein FtsW; Region: ftsW; TIGR02614
1116391015087	Asp23 family; Region: Asp23; pfam03780
1116391015088	calcium/proton exchanger (cax); Region: cax; TIGR00378
1116391015089	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1116391015090	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1116391015091	hypothetical protein; Provisional; Region: PRK13666
1116391015092	PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381
1116391015093	regulatory protein interface [polypeptide binding]; other site
1116391015094	regulatory phosphorylation site [posttranslational modification]; other site
1116391015095	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1116391015096	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391015097	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1116391015098	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1116391015099	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391015100	RNA binding surface [nucleotide binding]; other site
1116391015101	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1116391015102	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1116391015103	active site
1116391015104	HIGH motif; other site
1116391015105	dimer interface [polypeptide binding]; other site
1116391015106	KMSKS motif; other site
1116391015107	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391015108	RNA binding surface [nucleotide binding]; other site
1116391015109	acetyl-CoA synthetase; Provisional; Region: PRK04319
1116391015110	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1116391015111	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1116391015112	active site
1116391015113	acyl-activating enzyme (AAE) consensus motif; other site
1116391015114	putative CoA binding site [chemical binding]; other site
1116391015115	AMP binding site [chemical binding]; other site
1116391015116	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1116391015117	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1116391015118	active site
1116391015119	Zn binding site [ion binding]; other site
1116391015120	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1116391015121	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1116391015122	motif 1; other site
1116391015123	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1116391015124	active site
1116391015125	motif 2; other site
1116391015126	motif 3; other site
1116391015127	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1116391015128	anticodon binding site; other site
1116391015129	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1116391015130	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1116391015131	catabolite control protein A; Region: ccpA; TIGR01481
1116391015132	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391015133	DNA binding site [nucleotide binding]
1116391015134	domain linker motif; other site
1116391015135	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1116391015136	dimerization interface [polypeptide binding]; other site
1116391015137	effector binding site; other site
1116391015138	Predicted integral membrane protein [Function unknown]; Region: COG5652
1116391015139	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1116391015140	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1116391015141	proposed catalytic triad [active]
1116391015142	conserved cys residue [active]
1116391015143	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1116391015144	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1116391015145	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1116391015146	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1116391015147	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
1116391015148	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1116391015149	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1116391015150	active site turn [active]
1116391015151	phosphorylation site [posttranslational modification]
1116391015152	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1116391015153	HPr interaction site; other site
1116391015154	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1116391015155	active site
1116391015156	phosphorylation site [posttranslational modification]
1116391015157	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1116391015158	thiamine phosphate binding site [chemical binding]; other site
1116391015159	active site
1116391015160	pyrophosphate binding site [ion binding]; other site
1116391015161	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1116391015162	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1116391015163	putative active site [active]
1116391015164	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1116391015165	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1116391015166	hinge; other site
1116391015167	active site
1116391015168	CrcB-like protein; Region: CRCB; cl09114
1116391015169	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1116391015170	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1116391015171	active site residue [active]
1116391015172	shikimate kinase; Reviewed; Region: aroK; PRK00131
1116391015173	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1116391015174	ADP binding site [chemical binding]; other site
1116391015175	magnesium binding site [ion binding]; other site
1116391015176	putative shikimate binding site; other site
1116391015177	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1116391015178	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1116391015179	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1116391015180	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1116391015181	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391015182	NAD(P) binding site [chemical binding]; other site
1116391015183	active site
1116391015184	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1116391015185	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1116391015186	N- and C-terminal domain interface [polypeptide binding]; other site
1116391015187	active site
1116391015188	catalytic site [active]
1116391015189	metal binding site [ion binding]; metal-binding site
1116391015190	carbohydrate binding site [chemical binding]; other site
1116391015191	ATP binding site [chemical binding]; other site
1116391015192	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1116391015193	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391015194	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391015195	DNA binding site [nucleotide binding]
1116391015196	domain linker motif; other site
1116391015197	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391015198	dimerization interface [polypeptide binding]; other site
1116391015199	ligand binding site [chemical binding]; other site
1116391015200	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391015201	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1116391015202	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1116391015203	active site
1116391015204	catalytic triad [active]
1116391015205	oxyanion hole [active]
1116391015206	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391015207	metal binding site [ion binding]; metal-binding site
1116391015208	active site
1116391015209	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391015210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391015211	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391015212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391015213	dimer interface [polypeptide binding]; other site
1116391015214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391015215	ABC-ATPase subunit interface; other site
1116391015216	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391015217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391015218	dimer interface [polypeptide binding]; other site
1116391015219	conserved gate region; other site
1116391015220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391015221	ABC-ATPase subunit interface; other site
1116391015222	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391015223	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391015224	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391015225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391015226	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391015227	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391015228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391015229	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391015230	putative substrate translocation pore; other site
1116391015231	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1116391015232	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1116391015233	homodimer interface [polypeptide binding]; other site
1116391015234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391015235	catalytic residue [active]
1116391015236	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1116391015237	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1116391015238	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391015239	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391015240	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1116391015241	active site
1116391015242	motif I; other site
1116391015243	motif II; other site
1116391015244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391015245	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
1116391015246	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
1116391015247	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391015248	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1116391015249	Arginase family; Region: Arginase; cd09989
1116391015250	active site
1116391015251	Mn binding site [ion binding]; other site
1116391015252	oligomer interface [polypeptide binding]; other site
1116391015253	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1116391015254	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1116391015255	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391015256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391015257	dimerization interface [polypeptide binding]; other site
1116391015258	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391015259	dimer interface [polypeptide binding]; other site
1116391015260	putative CheW interface [polypeptide binding]; other site
1116391015261	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391015262	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391015263	metal binding site [ion binding]; metal-binding site
1116391015264	active site
1116391015265	I-site; other site
1116391015266	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391015267	dimer interface [polypeptide binding]; other site
1116391015268	phosphorylation site [posttranslational modification]
1116391015269	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391015270	ATP binding site [chemical binding]; other site
1116391015271	Mg2+ binding site [ion binding]; other site
1116391015272	G-X-G motif; other site
1116391015273	Divergent PAP2 family; Region: DUF212; pfam02681
1116391015274	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1116391015275	GTP binding site; other site
1116391015276	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391015277	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391015278	ligand binding site [chemical binding]; other site
1116391015279	flexible hinge region; other site
1116391015280	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1116391015281	putative switch regulator; other site
1116391015282	non-specific DNA interactions [nucleotide binding]; other site
1116391015283	DNA binding site [nucleotide binding]
1116391015284	sequence specific DNA binding site [nucleotide binding]; other site
1116391015285	putative cAMP binding site [chemical binding]; other site
1116391015286	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1116391015287	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391015288	Phosphotransferase enzyme family; Region: APH; pfam01636
1116391015289	active site
1116391015290	substrate binding site [chemical binding]; other site
1116391015291	ATP binding site [chemical binding]; other site
1116391015292	PilZ domain; Region: PilZ; pfam07238
1116391015293	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1116391015294	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1116391015295	active site
1116391015296	DNA binding site [nucleotide binding]
1116391015297	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1116391015298	DNA binding site [nucleotide binding]
1116391015299	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1116391015300	putative deacylase active site [active]
1116391015301	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
1116391015302	WYL domain; Region: WYL; cl14852
1116391015303	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391015304	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391015305	active site
1116391015306	metal binding site [ion binding]; metal-binding site
1116391015307	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1116391015308	Spore germination protein GerPC; Region: GerPC; pfam10737
1116391015309	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
1116391015310	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1116391015311	endonuclease subunit; Provisional; Region: 47; PHA02546
1116391015312	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1116391015313	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1116391015314	tetramer interfaces [polypeptide binding]; other site
1116391015315	binuclear metal-binding site [ion binding]; other site
1116391015316	hypothetical protein; Provisional; Region: PRK13679
1116391015317	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1116391015318	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391015319	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1116391015320	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391015321	Predicted transcriptional regulators [Transcription]; Region: COG1510
1116391015322	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391015323	putative DNA binding site [nucleotide binding]; other site
1116391015324	putative Zn2+ binding site [ion binding]; other site
1116391015325	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1116391015326	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391015327	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391015328	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391015329	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391015330	Walker A/P-loop; other site
1116391015331	ATP binding site [chemical binding]; other site
1116391015332	Q-loop/lid; other site
1116391015333	ABC transporter signature motif; other site
1116391015334	Walker B; other site
1116391015335	D-loop; other site
1116391015336	H-loop/switch region; other site
1116391015337	FtsX-like permease family; Region: FtsX; pfam02687
1116391015338	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391015339	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391015340	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391015341	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391015342	Walker A/P-loop; other site
1116391015343	ATP binding site [chemical binding]; other site
1116391015344	Q-loop/lid; other site
1116391015345	ABC transporter signature motif; other site
1116391015346	Walker B; other site
1116391015347	D-loop; other site
1116391015348	H-loop/switch region; other site
1116391015349	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391015350	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391015351	dimer interface [polypeptide binding]; other site
1116391015352	putative CheW interface [polypeptide binding]; other site
1116391015353	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1116391015354	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1116391015355	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1116391015356	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1116391015357	putative dimer interface [polypeptide binding]; other site
1116391015358	putative anticodon binding site; other site
1116391015359	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1116391015360	homodimer interface [polypeptide binding]; other site
1116391015361	motif 1; other site
1116391015362	motif 2; other site
1116391015363	active site
1116391015364	motif 3; other site
1116391015365	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1116391015366	propionate/acetate kinase; Provisional; Region: PRK12379
1116391015367	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1116391015368	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1116391015369	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1116391015370	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1116391015371	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1116391015372	substrate binding site [chemical binding]; other site
1116391015373	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1116391015374	substrate binding site [chemical binding]; other site
1116391015375	ligand binding site [chemical binding]; other site
1116391015376	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391015377	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391015378	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391015379	dimerization interface [polypeptide binding]; other site
1116391015380	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1116391015381	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1116391015382	putative active site [active]
1116391015383	catalytic triad [active]
1116391015384	putative dimer interface [polypeptide binding]; other site
1116391015385	transaminase; Reviewed; Region: PRK08068
1116391015386	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391015387	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391015388	homodimer interface [polypeptide binding]; other site
1116391015389	catalytic residue [active]
1116391015390	gamma-glutamyl kinase; Provisional; Region: PRK05429
1116391015391	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1116391015392	nucleotide binding site [chemical binding]; other site
1116391015393	homotetrameric interface [polypeptide binding]; other site
1116391015394	putative phosphate binding site [ion binding]; other site
1116391015395	putative allosteric binding site; other site
1116391015396	PUA domain; Region: PUA; pfam01472
1116391015397	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1116391015398	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1116391015399	putative catalytic cysteine [active]
1116391015400	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391015401	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1116391015402	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1116391015403	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
1116391015404	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1116391015405	dimer interface [polypeptide binding]; other site
1116391015406	active site
1116391015407	catalytic residue [active]
1116391015408	metal binding site [ion binding]; metal-binding site
1116391015409	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1116391015410	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1116391015411	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1116391015412	intersubunit interface [polypeptide binding]; other site
1116391015413	active site
1116391015414	Zn2+ binding site [ion binding]; other site
1116391015415	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1116391015416	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1116391015417	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391015418	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1116391015419	Walker A/P-loop; other site
1116391015420	ATP binding site [chemical binding]; other site
1116391015421	Q-loop/lid; other site
1116391015422	ABC transporter signature motif; other site
1116391015423	Walker B; other site
1116391015424	D-loop; other site
1116391015425	H-loop/switch region; other site
1116391015426	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
1116391015427	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391015428	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391015429	DNA binding residues [nucleotide binding]
1116391015430	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391015431	active site
1116391015432	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1116391015433	active site
1116391015434	dimer interface [polypeptide binding]; other site
1116391015435	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1116391015436	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1116391015437	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1116391015438	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1116391015439	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1116391015440	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1116391015441	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1116391015442	IMP binding site; other site
1116391015443	dimer interface [polypeptide binding]; other site
1116391015444	interdomain contacts; other site
1116391015445	partial ornithine binding site; other site
1116391015446	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1116391015447	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1116391015448	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1116391015449	catalytic site [active]
1116391015450	subunit interface [polypeptide binding]; other site
1116391015451	dihydroorotase; Validated; Region: pyrC; PRK09357
1116391015452	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1116391015453	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1116391015454	active site
1116391015455	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1116391015456	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1116391015457	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1116391015458	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1116391015459	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391015460	active site
1116391015461	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
1116391015462	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1116391015463	amidase catalytic site [active]
1116391015464	Zn binding residues [ion binding]; other site
1116391015465	substrate binding site [chemical binding]; other site
1116391015466	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391015467	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1116391015468	active site
1116391015469	catalytic triad [active]
1116391015470	oxyanion hole [active]
1116391015471	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391015472	Interdomain contacts; other site
1116391015473	Cytokine receptor motif; other site
1116391015474	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391015475	Interdomain contacts; other site
1116391015476	Cytokine receptor motif; other site
1116391015477	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1116391015478	Protein of unknown function (DUF2612); Region: DUF2612; pfam11041
1116391015479	Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299
1116391015480	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391015481	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
1116391015482	Protein of unknown function (DUF3383); Region: DUF3383; pfam11863
1116391015483	Protein of unknown function (DUF4054); Region: DUF4054; pfam13262
1116391015484	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834
1116391015485	Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950
1116391015486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566
1116391015487	Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979
1116391015488	SEC-C motif; Region: SEC-C; pfam02810
1116391015489	Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369
1116391015490	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
1116391015491	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
1116391015492	active site
1116391015493	conformational flexibility of ligand binding pocket; other site
1116391015494	ADP-ribosylating toxin turn-turn motif; other site
1116391015495	phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555
1116391015496	Protein of unknown function (DUF1073); Region: DUF1073; pfam06381
1116391015497	Phage terminase large subunit; Region: Terminase_3; cl12054
1116391015498	Terminase-like family; Region: Terminase_6; pfam03237
1116391015499	Terminase small subunit; Region: Terminase_2; pfam03592
1116391015500	conjugal transfer coupling protein TraG; Provisional; Region: PRK13822
1116391015501	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
1116391015502	Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775
1116391015503	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280
1116391015504	active site
1116391015505	putative DNA-binding cleft [nucleotide binding]; other site
1116391015506	dimer interface [polypeptide binding]; other site
1116391015507	replicative DNA helicase; Region: DnaB; TIGR00665
1116391015508	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1116391015509	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1116391015510	Walker A motif; other site
1116391015511	ATP binding site [chemical binding]; other site
1116391015512	Walker B motif; other site
1116391015513	Bacteriophage replication protein O; Region: Phage_rep_O; cl04545
1116391015514	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
1116391015515	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1116391015516	active site
1116391015517	catalytic site [active]
1116391015518	substrate binding site [chemical binding]; other site
1116391015519	RecT family; Region: RecT; cl04285
1116391015520	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1116391015521	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1116391015522	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1116391015523	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1116391015524	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391015525	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391015526	non-specific DNA binding site [nucleotide binding]; other site
1116391015527	salt bridge; other site
1116391015528	sequence-specific DNA binding site [nucleotide binding]; other site
1116391015529	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1116391015530	sequence-specific DNA binding site [nucleotide binding]; other site
1116391015531	salt bridge; other site
1116391015532	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1116391015533	Int/Topo IB signature motif; other site
1116391015534	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1116391015535	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1116391015536	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1116391015537	putative trimer interface [polypeptide binding]; other site
1116391015538	putative CoA binding site [chemical binding]; other site
1116391015539	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1116391015540	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1116391015541	metal binding site [ion binding]; metal-binding site
1116391015542	putative dimer interface [polypeptide binding]; other site
1116391015543	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1116391015544	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391015545	RNA binding surface [nucleotide binding]; other site
1116391015546	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1116391015547	active site
1116391015548	lipoprotein signal peptidase; Provisional; Region: PRK14787
1116391015549	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
1116391015550	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1116391015551	DivIVA protein; Region: DivIVA; pfam05103
1116391015552	DivIVA domain; Region: DivI1A_domain; TIGR03544
1116391015553	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1116391015554	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391015555	RNA binding surface [nucleotide binding]; other site
1116391015556	Protein of unknown function (DUF552); Region: DUF552; cl00775
1116391015557	YGGT family; Region: YGGT; pfam02325
1116391015558	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1116391015559	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1116391015560	catalytic residue [active]
1116391015561	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1116391015562	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1116391015563	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1116391015564	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391015565	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1116391015566	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391015567	DNA binding residues [nucleotide binding]
1116391015568	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1116391015569	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391015570	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391015571	DNA binding residues [nucleotide binding]
1116391015572	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1116391015573	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1116391015574	cell division protein FtsZ; Validated; Region: PRK09330
1116391015575	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1116391015576	nucleotide binding site [chemical binding]; other site
1116391015577	SulA interaction site; other site
1116391015578	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1116391015579	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1116391015580	nucleotide binding site [chemical binding]; other site
1116391015581	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
1116391015582	Cell division protein FtsA; Region: FtsA; pfam14450
1116391015583	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1116391015584	Cell division protein FtsQ; Region: FtsQ; pfam03799
1116391015585	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1116391015586	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1116391015587	hinge; other site
1116391015588	active site
1116391015589	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1116391015590	FAD binding domain; Region: FAD_binding_4; pfam01565
1116391015591	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1116391015592	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1116391015593	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1116391015594	active site
1116391015595	homodimer interface [polypeptide binding]; other site
1116391015596	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1116391015597	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1116391015598	TrkA-N domain; Region: TrkA_N; pfam02254
1116391015599	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1116391015600	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1116391015601	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1116391015602	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1116391015603	Mg++ binding site [ion binding]; other site
1116391015604	putative catalytic motif [active]
1116391015605	putative substrate binding site [chemical binding]; other site
1116391015606	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1116391015607	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1116391015608	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1116391015609	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1116391015610	UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085
1116391015611	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1116391015612	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1116391015613	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1116391015614	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1116391015615	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391015616	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
1116391015617	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1116391015618	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1116391015619	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391015620	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1116391015621	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1116391015622	Cell division protein FtsL; Region: FtsL; cl11433
1116391015623	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1116391015624	MraW methylase family; Region: Methyltransf_5; pfam01795
1116391015625	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1116391015626	MraZ protein; Region: MraZ; pfam02381
1116391015627	MraZ protein; Region: MraZ; pfam02381
1116391015628	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
1116391015629	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1116391015630	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1116391015631	homotetramer interface [polypeptide binding]; other site
1116391015632	ligand binding site [chemical binding]; other site
1116391015633	catalytic site [active]
1116391015634	NAD binding site [chemical binding]; other site
1116391015635	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1116391015636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1116391015637	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
1116391015638	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1116391015639	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391015640	Walker A/P-loop; other site
1116391015641	ATP binding site [chemical binding]; other site
1116391015642	Q-loop/lid; other site
1116391015643	ABC transporter signature motif; other site
1116391015644	Walker B; other site
1116391015645	D-loop; other site
1116391015646	H-loop/switch region; other site
1116391015647	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391015648	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1116391015649	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391015650	Walker A/P-loop; other site
1116391015651	ATP binding site [chemical binding]; other site
1116391015652	Q-loop/lid; other site
1116391015653	ABC transporter signature motif; other site
1116391015654	Walker B; other site
1116391015655	D-loop; other site
1116391015656	H-loop/switch region; other site
1116391015657	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1116391015658	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1116391015659	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1116391015660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391015661	dimer interface [polypeptide binding]; other site
1116391015662	conserved gate region; other site
1116391015663	putative PBP binding loops; other site
1116391015664	ABC-ATPase subunit interface; other site
1116391015665	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1116391015666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391015667	dimer interface [polypeptide binding]; other site
1116391015668	conserved gate region; other site
1116391015669	putative PBP binding loops; other site
1116391015670	ABC-ATPase subunit interface; other site
1116391015671	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1116391015672	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1116391015673	peptide binding site [polypeptide binding]; other site
1116391015674	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1116391015675	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1116391015676	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1116391015677	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1116391015678	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1116391015679	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
1116391015680	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1116391015681	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1116391015682	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1116391015683	putative active site [active]
1116391015684	PhoH-like protein; Region: PhoH; pfam02562
1116391015685	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1116391015686	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1116391015687	YlaH-like protein; Region: YlaH; pfam14036
1116391015688	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1116391015689	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1116391015690	G1 box; other site
1116391015691	putative GEF interaction site [polypeptide binding]; other site
1116391015692	GTP/Mg2+ binding site [chemical binding]; other site
1116391015693	Switch I region; other site
1116391015694	G2 box; other site
1116391015695	G3 box; other site
1116391015696	Switch II region; other site
1116391015697	G4 box; other site
1116391015698	G5 box; other site
1116391015699	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1116391015700	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1116391015701	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1116391015702	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1116391015703	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1116391015704	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1116391015705	Ligand Binding Site [chemical binding]; other site
1116391015706	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1116391015707	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1116391015708	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391015709	catalytic residue [active]
1116391015710	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1116391015711	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1116391015712	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1116391015713	catalytic residue [active]
1116391015714	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1116391015715	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
1116391015716	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1116391015717	active site
1116391015718	catalytic triad [active]
1116391015719	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1116391015720	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1116391015721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1116391015722	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1116391015723	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1116391015724	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1116391015725	Family of unknown function (DUF633); Region: DUF633; pfam04816
1116391015726	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1116391015727	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1116391015728	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1116391015729	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391015730	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1116391015731	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391015732	DNA binding residues [nucleotide binding]
1116391015733	DNA primase; Validated; Region: dnaG; PRK05667
1116391015734	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1116391015735	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1116391015736	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1116391015737	active site
1116391015738	metal binding site [ion binding]; metal-binding site
1116391015739	interdomain interaction site; other site
1116391015740	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1116391015741	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
1116391015742	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1116391015743	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1116391015744	Recombination protein O N terminal; Region: RecO_N; pfam11967
1116391015745	Recombination protein O C terminal; Region: RecO_C; pfam02565
1116391015746	YqzL-like protein; Region: YqzL; pfam14006
1116391015747	GTPase Era; Reviewed; Region: era; PRK00089
1116391015748	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1116391015749	G1 box; other site
1116391015750	GTP/Mg2+ binding site [chemical binding]; other site
1116391015751	Switch I region; other site
1116391015752	G2 box; other site
1116391015753	Switch II region; other site
1116391015754	G3 box; other site
1116391015755	G4 box; other site
1116391015756	G5 box; other site
1116391015757	KH domain; Region: KH_2; pfam07650
1116391015758	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1116391015759	active site
1116391015760	catalytic motif [active]
1116391015761	Zn binding site [ion binding]; other site
1116391015762	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1116391015763	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1116391015764	active site
1116391015765	metal-binding heat shock protein; Provisional; Region: PRK00016
1116391015766	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1116391015767	PhoH-like protein; Region: PhoH; pfam02562
1116391015768	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1116391015769	YabP family; Region: YabP; cl06766
1116391015770	hypothetical protein; Provisional; Region: PRK13665
1116391015771	Yqey-like protein; Region: YqeY; pfam09424
1116391015772	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1116391015773	nucleotide binding site/active site [active]
1116391015774	HIT family signature motif; other site
1116391015775	catalytic residue [active]
1116391015776	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391015777	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391015778	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1116391015779	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391015780	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1116391015781	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391015782	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1116391015783	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391015784	ABC transporter signature motif; other site
1116391015785	Walker B; other site
1116391015786	D-loop; other site
1116391015787	H-loop/switch region; other site
1116391015788	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1116391015789	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1116391015790	Walker A/P-loop; other site
1116391015791	ATP binding site [chemical binding]; other site
1116391015792	Q-loop/lid; other site
1116391015793	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1116391015794	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391015795	active site
1116391015796	metal binding site [ion binding]; metal-binding site
1116391015797	DNA binding site [nucleotide binding]
1116391015798	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1116391015799	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1116391015800	Part of AAA domain; Region: AAA_19; pfam13245
1116391015801	Family description; Region: UvrD_C_2; pfam13538
1116391015802	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1116391015803	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1116391015804	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1116391015805	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1116391015806	dimer interface [polypeptide binding]; other site
1116391015807	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1116391015808	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1116391015809	putative RNA binding site [nucleotide binding]; other site
1116391015810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391015811	S-adenosylmethionine binding site [chemical binding]; other site
1116391015812	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1116391015813	active site
1116391015814	Ap6A binding site [chemical binding]; other site
1116391015815	nudix motif; other site
1116391015816	metal binding site [ion binding]; metal-binding site
1116391015817	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1116391015818	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1116391015819	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391015820	FeS/SAM binding site; other site
1116391015821	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1116391015822	RNA methyltransferase, RsmE family; Region: TIGR00046
1116391015823	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1116391015824	Peptidase family M50; Region: Peptidase_M50; pfam02163
1116391015825	active site
1116391015826	putative substrate binding region [chemical binding]; other site
1116391015827	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1116391015828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391015829	S-adenosylmethionine binding site [chemical binding]; other site
1116391015830	YfhD-like protein; Region: YfhD; pfam14151
1116391015831	chaperone protein DnaJ; Provisional; Region: PRK14280
1116391015832	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1116391015833	HSP70 interaction site [polypeptide binding]; other site
1116391015834	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1116391015835	substrate binding site [polypeptide binding]; other site
1116391015836	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1116391015837	Zn binding sites [ion binding]; other site
1116391015838	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1116391015839	dimer interface [polypeptide binding]; other site
1116391015840	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1116391015841	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1116391015842	nucleotide binding site [chemical binding]; other site
1116391015843	NEF interaction site [polypeptide binding]; other site
1116391015844	SBD interface [polypeptide binding]; other site
1116391015845	GrpE; Region: GrpE; pfam01025
1116391015846	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1116391015847	dimer interface [polypeptide binding]; other site
1116391015848	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1116391015849	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
1116391015850	thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339
1116391015851	ATP/Mg binding site [chemical binding]; other site
1116391015852	ring oligomerisation interface [polypeptide binding]; other site
1116391015853	hinge regions; other site
1116391015854	stacking interactions; other site
1116391015855	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1116391015856	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1116391015857	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1116391015858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391015859	Coenzyme A binding pocket [chemical binding]; other site
1116391015860	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1116391015861	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391015862	FeS/SAM binding site; other site
1116391015863	HemN C-terminal domain; Region: HemN_C; pfam06969
1116391015864	GTP-binding protein LepA; Provisional; Region: PRK05433
1116391015865	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1116391015866	G1 box; other site
1116391015867	putative GEF interaction site [polypeptide binding]; other site
1116391015868	GTP/Mg2+ binding site [chemical binding]; other site
1116391015869	Switch I region; other site
1116391015870	G2 box; other site
1116391015871	G3 box; other site
1116391015872	Switch II region; other site
1116391015873	G4 box; other site
1116391015874	G5 box; other site
1116391015875	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1116391015876	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1116391015877	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1116391015878	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1116391015879	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1116391015880	germination protease; Provisional; Region: PRK02858
1116391015881	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1116391015882	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1116391015883	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1116391015884	Putative zinc-finger; Region: zf-HC2; pfam13490
1116391015885	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
1116391015886	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391015887	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391015888	DNA binding residues [nucleotide binding]
1116391015889	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391015890	EamA-like transporter family; Region: EamA; pfam00892
1116391015891	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1116391015892	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1116391015893	[2Fe-2S] cluster binding site [ion binding]; other site
1116391015894	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1116391015895	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391015896	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1116391015897	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1116391015898	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1116391015899	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1116391015900	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1116391015901	Competence protein; Region: Competence; pfam03772
1116391015902	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391015903	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1116391015904	catalytic motif [active]
1116391015905	Zn binding site [ion binding]; other site
1116391015906	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1116391015907	late competence protein ComER; Validated; Region: PRK07680
1116391015908	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1116391015909	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1116391015910	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1116391015911	HIGH motif; other site
1116391015912	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1116391015913	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1116391015914	active site
1116391015915	KMSKS motif; other site
1116391015916	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1116391015917	tRNA binding surface [nucleotide binding]; other site
1116391015918	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391015919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391015920	S-adenosylmethionine binding site [chemical binding]; other site
1116391015921	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1116391015922	S1 domain; Region: S1_2; pfam13509
1116391015923	S1 domain; Region: S1_2; pfam13509
1116391015924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1116391015925	putative DNA binding site [nucleotide binding]; other site
1116391015926	putative Zn2+ binding site [ion binding]; other site
1116391015927	Oligomerisation domain; Region: Oligomerisation; cl00519
1116391015928	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391015929	Zn2+ binding site [ion binding]; other site
1116391015930	Mg2+ binding site [ion binding]; other site
1116391015931	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1116391015932	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1116391015933	active site
1116391015934	(T/H)XGH motif; other site
1116391015935	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1116391015936	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1116391015937	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1116391015938	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1116391015939	shikimate binding site; other site
1116391015940	NAD(P) binding site [chemical binding]; other site
1116391015941	GTPase YqeH; Provisional; Region: PRK13796
1116391015942	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1116391015943	GTP/Mg2+ binding site [chemical binding]; other site
1116391015944	G4 box; other site
1116391015945	G5 box; other site
1116391015946	G1 box; other site
1116391015947	Switch I region; other site
1116391015948	G2 box; other site
1116391015949	G3 box; other site
1116391015950	Switch II region; other site
1116391015951	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
1116391015952	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391015953	active site
1116391015954	motif I; other site
1116391015955	motif II; other site
1116391015956	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1116391015957	dimanganese center [ion binding]; other site
1116391015958	CotJB protein; Region: CotJB; pfam12652
1116391015959	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1116391015960	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1116391015961	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1116391015962	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1116391015963	Protein of unknown function DUF58; Region: DUF58; pfam01882
1116391015964	MoxR-like ATPases [General function prediction only]; Region: COG0714
1116391015965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391015966	Walker A motif; other site
1116391015967	ATP binding site [chemical binding]; other site
1116391015968	Walker B motif; other site
1116391015969	arginine finger; other site
1116391015970	SpoVA protein; Region: SpoVA; cl04298
1116391015971	stage V sporulation protein AD; Provisional; Region: PRK12404
1116391015972	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
1116391015973	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
1116391015974	Predicted membrane protein [Function unknown]; Region: COG2323
1116391015975	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1116391015976	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1116391015977	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1116391015978	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1116391015979	ligand binding site [chemical binding]; other site
1116391015980	flexible hinge region; other site
1116391015981	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1116391015982	putative switch regulator; other site
1116391015983	non-specific DNA interactions [nucleotide binding]; other site
1116391015984	DNA binding site [nucleotide binding]
1116391015985	sequence specific DNA binding site [nucleotide binding]; other site
1116391015986	putative cAMP binding site [chemical binding]; other site
1116391015987	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391015988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391015989	active site
1116391015990	phosphorylation site [posttranslational modification]
1116391015991	intermolecular recognition site; other site
1116391015992	dimerization interface [polypeptide binding]; other site
1116391015993	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
1116391015994	Repair protein; Region: Repair_PSII; pfam04536
1116391015995	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1116391015996	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391015997	Coenzyme A binding pocket [chemical binding]; other site
1116391015998	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
1116391015999	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1116391016000	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391016001	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
1116391016002	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1116391016003	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391016004	NAD(P) binding site [chemical binding]; other site
1116391016005	active site
1116391016006	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391016007	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1116391016008	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391016009	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016010	dimerization interface [polypeptide binding]; other site
1116391016011	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391016012	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391016013	dimer interface [polypeptide binding]; other site
1116391016014	putative CheW interface [polypeptide binding]; other site
1116391016015	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391016016	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1116391016017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391016018	Walker A/P-loop; other site
1116391016019	ATP binding site [chemical binding]; other site
1116391016020	Q-loop/lid; other site
1116391016021	ABC transporter signature motif; other site
1116391016022	Walker B; other site
1116391016023	D-loop; other site
1116391016024	H-loop/switch region; other site
1116391016025	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391016026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391016027	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391016028	Walker A/P-loop; other site
1116391016029	ATP binding site [chemical binding]; other site
1116391016030	Q-loop/lid; other site
1116391016031	ABC transporter signature motif; other site
1116391016032	Walker B; other site
1116391016033	D-loop; other site
1116391016034	H-loop/switch region; other site
1116391016035	MULE transposase domain; Region: MULE; pfam10551
1116391016036	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391016037	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391016038	Walker A/P-loop; other site
1116391016039	ATP binding site [chemical binding]; other site
1116391016040	Q-loop/lid; other site
1116391016041	ABC transporter signature motif; other site
1116391016042	Walker B; other site
1116391016043	D-loop; other site
1116391016044	H-loop/switch region; other site
1116391016045	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391016046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016047	dimer interface [polypeptide binding]; other site
1116391016048	conserved gate region; other site
1116391016049	putative PBP binding loops; other site
1116391016050	ABC-ATPase subunit interface; other site
1116391016051	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391016052	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391016053	substrate binding pocket [chemical binding]; other site
1116391016054	membrane-bound complex binding site; other site
1116391016055	hinge residues; other site
1116391016056	drug efflux system protein MdtG; Provisional; Region: PRK09874
1116391016057	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391016058	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1116391016059	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1116391016060	putative transposase OrfB; Reviewed; Region: PHA02517
1116391016061	HTH-like domain; Region: HTH_21; pfam13276
1116391016062	Integrase core domain; Region: rve; pfam00665
1116391016063	Integrase core domain; Region: rve_3; pfam13683
1116391016064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391016065	Transposase; Region: HTH_Tnp_1; cl17663
1116391016066	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1116391016067	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1116391016068	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1116391016069	active site
1116391016070	catalytic site [active]
1116391016071	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016072	dimerization interface [polypeptide binding]; other site
1116391016073	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391016074	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391016075	dimer interface [polypeptide binding]; other site
1116391016076	putative CheW interface [polypeptide binding]; other site
1116391016077	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1116391016078	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391016079	ligand binding site [chemical binding]; other site
1116391016080	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391016081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016082	active site
1116391016083	phosphorylation site [posttranslational modification]
1116391016084	intermolecular recognition site; other site
1116391016085	dimerization interface [polypeptide binding]; other site
1116391016086	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391016087	dimer interface [polypeptide binding]; other site
1116391016088	phosphorylation site [posttranslational modification]
1116391016089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016090	ATP binding site [chemical binding]; other site
1116391016091	Mg2+ binding site [ion binding]; other site
1116391016092	G-X-G motif; other site
1116391016093	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
1116391016094	CheB methylesterase; Region: CheB_methylest; pfam01339
1116391016095	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1116391016096	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1116391016097	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1116391016098	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1116391016099	active site
1116391016100	intersubunit interactions; other site
1116391016101	catalytic residue [active]
1116391016102	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1116391016103	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1116391016104	TPP-binding site [chemical binding]; other site
1116391016105	dimer interface [polypeptide binding]; other site
1116391016106	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1116391016107	PYR/PP interface [polypeptide binding]; other site
1116391016108	dimer interface [polypeptide binding]; other site
1116391016109	TPP binding site [chemical binding]; other site
1116391016110	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391016111	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391016112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391016113	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391016114	dimerization interface [polypeptide binding]; other site
1116391016115	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016116	dimerization interface [polypeptide binding]; other site
1116391016117	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391016118	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391016119	dimer interface [polypeptide binding]; other site
1116391016120	putative CheW interface [polypeptide binding]; other site
1116391016121	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1116391016122	CoenzymeA binding site [chemical binding]; other site
1116391016123	subunit interaction site [polypeptide binding]; other site
1116391016124	PHB binding site; other site
1116391016125	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1116391016126	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1116391016127	acyl-activating enzyme (AAE) consensus motif; other site
1116391016128	putative AMP binding site [chemical binding]; other site
1116391016129	putative active site [active]
1116391016130	putative CoA binding site [chemical binding]; other site
1116391016131	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1116391016132	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1116391016133	active site
1116391016134	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1116391016135	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1116391016136	dimer interface [polypeptide binding]; other site
1116391016137	active site
1116391016138	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1116391016139	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1116391016140	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1116391016141	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1116391016142	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1116391016143	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1116391016144	substrate binding site [chemical binding]; other site
1116391016145	oxyanion hole (OAH) forming residues; other site
1116391016146	trimer interface [polypeptide binding]; other site
1116391016147	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1116391016148	4Fe-4S binding domain; Region: Fer4; cl02805
1116391016149	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1116391016150	Cysteine-rich domain; Region: CCG; pfam02754
1116391016151	Cysteine-rich domain; Region: CCG; pfam02754
1116391016152	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391016153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391016154	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1116391016155	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1116391016156	Ligand binding site [chemical binding]; other site
1116391016157	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1116391016158	uracil transporter; Provisional; Region: PRK10720
1116391016159	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391016160	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1116391016161	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391016162	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391016163	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391016164	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1116391016165	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391016166	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391016167	substrate binding pocket [chemical binding]; other site
1116391016168	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1116391016169	membrane-bound complex binding site; other site
1116391016170	hinge residues; other site
1116391016171	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1116391016172	regulatory protein interface [polypeptide binding]; other site
1116391016173	active site
1116391016174	regulatory phosphorylation site [posttranslational modification]; other site
1116391016175	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1116391016176	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1116391016177	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1116391016178	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1116391016179	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391016180	putative active site [active]
1116391016181	heme pocket [chemical binding]; other site
1116391016182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016183	ATP binding site [chemical binding]; other site
1116391016184	Mg2+ binding site [ion binding]; other site
1116391016185	G-X-G motif; other site
1116391016186	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1116391016187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016188	active site
1116391016189	phosphorylation site [posttranslational modification]
1116391016190	intermolecular recognition site; other site
1116391016191	dimerization interface [polypeptide binding]; other site
1116391016192	Transcriptional regulator; Region: CitT; pfam12431
1116391016193	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1116391016194	LysE type translocator; Region: LysE; pfam01810
1116391016195	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1116391016196	Spore germination protein; Region: Spore_permease; cl17796
1116391016197	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391016198	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391016199	active site
1116391016200	non-prolyl cis peptide bond; other site
1116391016201	Predicted transcriptional regulator [Transcription]; Region: COG4189
1116391016202	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391016203	dimerization interface [polypeptide binding]; other site
1116391016204	putative DNA binding site [nucleotide binding]; other site
1116391016205	putative Zn2+ binding site [ion binding]; other site
1116391016206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1116391016207	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1116391016208	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1116391016209	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1116391016210	active site
1116391016211	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016213	dimer interface [polypeptide binding]; other site
1116391016214	conserved gate region; other site
1116391016215	putative PBP binding loops; other site
1116391016216	ABC-ATPase subunit interface; other site
1116391016217	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391016218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016219	dimer interface [polypeptide binding]; other site
1116391016220	ABC-ATPase subunit interface; other site
1116391016221	putative PBP binding loops; other site
1116391016222	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016223	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391016224	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1116391016225	active site
1116391016226	Predicted transcriptional regulator [Transcription]; Region: COG4189
1116391016227	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391016228	dimerization interface [polypeptide binding]; other site
1116391016229	putative DNA binding site [nucleotide binding]; other site
1116391016230	putative Zn2+ binding site [ion binding]; other site
1116391016231	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391016232	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391016233	Metal-binding active site; metal-binding site
1116391016234	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391016235	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391016236	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016237	alpha-galactosidase; Region: PLN02808; cl17638
1116391016238	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391016239	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391016240	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391016241	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1116391016242	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1116391016243	intersubunit interface [polypeptide binding]; other site
1116391016244	active site
1116391016245	zinc binding site [ion binding]; other site
1116391016246	Na+ binding site [ion binding]; other site
1116391016247	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1116391016248	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1116391016249	tetrameric interface [polypeptide binding]; other site
1116391016250	NAD binding site [chemical binding]; other site
1116391016251	catalytic residues [active]
1116391016252	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391016253	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1116391016254	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1116391016255	PYR/PP interface [polypeptide binding]; other site
1116391016256	dimer interface [polypeptide binding]; other site
1116391016257	TPP binding site [chemical binding]; other site
1116391016258	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1116391016259	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1116391016260	TPP-binding site; other site
1116391016261	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016263	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1116391016264	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1116391016265	siderophore binding site; other site
1116391016266	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391016267	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391016268	dimer interface [polypeptide binding]; other site
1116391016269	putative PBP binding regions; other site
1116391016270	ABC-ATPase subunit  interface; other site
1116391016271	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391016272	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391016273	ABC-ATPase subunit  interface; other site
1116391016274	dimer interface [polypeptide binding]; other site
1116391016275	putative PBP binding regions; other site
1116391016276	Predicted ATPase [General function prediction only]; Region: COG3910
1116391016277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391016278	Walker A/P-loop; other site
1116391016279	ATP binding site [chemical binding]; other site
1116391016280	Q-loop/lid; other site
1116391016281	ABC transporter signature motif; other site
1116391016282	Walker B; other site
1116391016283	D-loop; other site
1116391016284	H-loop/switch region; other site
1116391016285	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016286	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391016287	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1116391016288	inhibitor binding site; inhibition site
1116391016289	active site
1116391016290	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016292	dimer interface [polypeptide binding]; other site
1116391016293	conserved gate region; other site
1116391016294	putative PBP binding loops; other site
1116391016295	ABC-ATPase subunit interface; other site
1116391016296	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391016297	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016298	dimer interface [polypeptide binding]; other site
1116391016299	conserved gate region; other site
1116391016300	ABC-ATPase subunit interface; other site
1116391016301	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016302	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016303	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016304	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391016305	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
1116391016306	active site
1116391016307	Pectate lyase; Region: Pec_lyase_C; cl01593
1116391016308	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391016309	Interdomain contacts; other site
1116391016310	Cytokine receptor motif; other site
1116391016311	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391016312	Interdomain contacts; other site
1116391016313	Cytokine receptor motif; other site
1116391016314	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391016315	Interdomain contacts; other site
1116391016316	Cytokine receptor motif; other site
1116391016317	putative pectinesterase; Region: PLN02432; cl01911
1116391016318	Pectinesterase; Region: Pectinesterase; pfam01095
1116391016319	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
1116391016320	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1116391016321	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1116391016322	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391016323	putative metal binding site; other site
1116391016324	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1116391016325	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1116391016326	binding surface
1116391016327	TPR motif; other site
1116391016328	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1116391016329	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1116391016330	active site
1116391016331	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1116391016332	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391016333	putative homodimer interface [polypeptide binding]; other site
1116391016334	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1116391016335	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1116391016336	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1116391016337	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391016338	putative homodimer interface [polypeptide binding]; other site
1116391016339	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1116391016340	metal binding site [ion binding]; metal-binding site
1116391016341	active site
1116391016342	Putative esterase; Region: Esterase; pfam00756
1116391016343	S-formylglutathione hydrolase; Region: PLN02442
1116391016344	Putative esterase; Region: Esterase; pfam00756
1116391016345	S-layer homology domain; Region: SLH; pfam00395
1116391016346	S-layer homology domain; Region: SLH; pfam00395
1116391016347	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1116391016348	active site
1116391016349	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1116391016350	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1116391016351	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391016352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391016353	homodimer interface [polypeptide binding]; other site
1116391016354	catalytic residue [active]
1116391016355	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391016356	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016357	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016358	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016359	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1116391016360	catalytic core [active]
1116391016361	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391016362	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391016363	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391016364	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391016365	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
1116391016366	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1116391016367	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391016368	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391016369	DNA binding site [nucleotide binding]
1116391016370	domain linker motif; other site
1116391016371	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1116391016372	dimerization interface [polypeptide binding]; other site
1116391016373	ligand binding site [chemical binding]; other site
1116391016374	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391016375	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391016376	Interdomain contacts; other site
1116391016377	Cytokine receptor motif; other site
1116391016378	Cellulose binding domain; Region: CBM_3; pfam00942
1116391016379	Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297
1116391016380	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
1116391016381	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391016382	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391016383	Interdomain contacts; other site
1116391016384	Cytokine receptor motif; other site
1116391016385	Cellulose binding domain; Region: CBM_3; pfam00942
1116391016386	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1116391016387	dimer interface [polypeptide binding]; other site
1116391016388	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391016389	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1116391016390	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391016391	Coenzyme A binding pocket [chemical binding]; other site
1116391016392	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391016393	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391016394	active site
1116391016395	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391016396	Putative transcription activator [Transcription]; Region: TenA; COG0819
1116391016397	acetylornithine deacetylase; Validated; Region: PRK08596
1116391016398	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1116391016399	metal binding site [ion binding]; metal-binding site
1116391016400	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1116391016401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391016402	Walker A/P-loop; other site
1116391016403	ATP binding site [chemical binding]; other site
1116391016404	Q-loop/lid; other site
1116391016405	ABC transporter signature motif; other site
1116391016406	Walker B; other site
1116391016407	D-loop; other site
1116391016408	H-loop/switch region; other site
1116391016409	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1116391016410	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1116391016411	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1116391016412	Walker A/P-loop; other site
1116391016413	ATP binding site [chemical binding]; other site
1116391016414	Q-loop/lid; other site
1116391016415	ABC transporter signature motif; other site
1116391016416	Walker B; other site
1116391016417	D-loop; other site
1116391016418	H-loop/switch region; other site
1116391016419	BioY family; Region: BioY; pfam02632
1116391016420	Glycosyl hydrolase family 43; Region: GH43_5; cd08984
1116391016421	active site
1116391016422	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1116391016423	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1116391016424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391016425	DNA-binding site [nucleotide binding]; DNA binding site
1116391016426	FCD domain; Region: FCD; pfam07729
1116391016427	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1116391016428	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1116391016429	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1116391016430	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1116391016431	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1116391016432	CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288
1116391016433	Cysteine-rich domain; Region: CCG; pfam02754
1116391016434	Cysteine-rich domain; Region: CCG; pfam02754
1116391016435	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391016436	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1116391016437	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391016438	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1116391016439	N- and C-terminal domain interface [polypeptide binding]; other site
1116391016440	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1116391016441	active site
1116391016442	putative catalytic site [active]
1116391016443	metal binding site [ion binding]; metal-binding site
1116391016444	ATP binding site [chemical binding]; other site
1116391016445	carbohydrate binding site [chemical binding]; other site
1116391016446	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
1116391016447	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1116391016448	Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751
1116391016449	short chain dehydrogenase; Validated; Region: PRK08324
1116391016450	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1116391016451	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
1116391016452	putative NAD(P) binding site [chemical binding]; other site
1116391016453	active site
1116391016454	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1116391016455	intersubunit interface [polypeptide binding]; other site
1116391016456	active site
1116391016457	Zn2+ binding site [ion binding]; other site
1116391016458	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1116391016459	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1116391016460	active site
1116391016461	intersubunit interface [polypeptide binding]; other site
1116391016462	Zn2+ binding site [ion binding]; other site
1116391016463	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1116391016464	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391016465	MarR family; Region: MarR_2; pfam12802
1116391016466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391016467	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391016468	putative substrate translocation pore; other site
1116391016469	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391016470	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1116391016471	NAD(P) binding site [chemical binding]; other site
1116391016472	active site
1116391016473	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391016474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016475	active site
1116391016476	phosphorylation site [posttranslational modification]
1116391016477	intermolecular recognition site; other site
1116391016478	dimerization interface [polypeptide binding]; other site
1116391016479	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391016480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016481	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1116391016482	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1116391016483	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1116391016484	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391016485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391016486	homodimer interface [polypeptide binding]; other site
1116391016487	catalytic residue [active]
1116391016488	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1116391016489	active site
1116391016490	catalytic triad [active]
1116391016491	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1116391016492	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391016493	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016494	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391016495	Predicted membrane protein [Function unknown]; Region: COG4709
1116391016496	Regulatory protein YrvL; Region: YrvL; pfam14184
1116391016497	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1116391016498	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1116391016499	Domain of unknown function (DUF4284); Region: DUF4284; pfam14112
1116391016500	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1116391016501	dimerization interface [polypeptide binding]; other site
1116391016502	NAD binding site [chemical binding]; other site
1116391016503	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1116391016504	ligand binding site [chemical binding]; other site
1116391016505	catalytic site [active]
1116391016506	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391016507	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391016508	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1116391016509	Walker A/P-loop; other site
1116391016510	ATP binding site [chemical binding]; other site
1116391016511	Q-loop/lid; other site
1116391016512	ABC transporter signature motif; other site
1116391016513	Walker B; other site
1116391016514	D-loop; other site
1116391016515	H-loop/switch region; other site
1116391016516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391016517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391016518	metal binding site [ion binding]; metal-binding site
1116391016519	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
1116391016520	substrate binding site [chemical binding]; other site
1116391016521	active site
1116391016522	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1116391016523	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1116391016524	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1116391016525	S-layer homology domain; Region: SLH; pfam00395
1116391016526	S-layer homology domain; Region: SLH; pfam00395
1116391016527	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391016528	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391016529	substrate binding pocket [chemical binding]; other site
1116391016530	membrane-bound complex binding site; other site
1116391016531	hinge residues; other site
1116391016532	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391016533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016534	dimer interface [polypeptide binding]; other site
1116391016535	conserved gate region; other site
1116391016536	putative PBP binding loops; other site
1116391016537	ABC-ATPase subunit interface; other site
1116391016538	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391016539	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391016540	Walker A/P-loop; other site
1116391016541	ATP binding site [chemical binding]; other site
1116391016542	Q-loop/lid; other site
1116391016543	ABC transporter signature motif; other site
1116391016544	Walker B; other site
1116391016545	D-loop; other site
1116391016546	H-loop/switch region; other site
1116391016547	Peptidase C26; Region: Peptidase_C26; pfam07722
1116391016548	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1116391016549	catalytic triad [active]
1116391016550	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1116391016551	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1116391016552	nucleotide binding site [chemical binding]; other site
1116391016553	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391016554	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1116391016555	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391016556	Transglycosylase; Region: Transgly; pfam00912
1116391016557	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1116391016558	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391016559	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1116391016560	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1116391016561	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1116391016562	putative pectinesterase; Region: PLN02432; cl01911
1116391016563	YhfH-like protein; Region: YhfH; pfam14149
1116391016564	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1116391016565	Protein export membrane protein; Region: SecD_SecF; cl14618
1116391016566	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391016567	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1116391016568	DNA binding residues [nucleotide binding]
1116391016569	drug binding residues [chemical binding]; other site
1116391016570	dimer interface [polypeptide binding]; other site
1116391016571	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1116391016572	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391016573	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391016574	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391016575	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391016576	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1116391016577	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1116391016578	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1116391016579	metal-binding site [ion binding]
1116391016580	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1116391016581	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1116391016582	metal-binding site [ion binding]
1116391016583	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1116391016584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391016585	motif II; other site
1116391016586	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1116391016587	metal-binding site [ion binding]
1116391016588	Arginase family; Region: Arginase; cd09989
1116391016589	active site
1116391016590	Mn binding site [ion binding]; other site
1116391016591	oligomer interface [polypeptide binding]; other site
1116391016592	Arginase family; Region: Arginase; cd09989
1116391016593	active site
1116391016594	Mn binding site [ion binding]; other site
1116391016595	oligomer interface [polypeptide binding]; other site
1116391016596	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391016597	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391016598	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391016599	dimerization interface [polypeptide binding]; other site
1116391016600	S-methylmethionine transporter; Provisional; Region: PRK11387
1116391016601	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1116391016602	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1116391016603	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1116391016604	NAD(P) binding site [chemical binding]; other site
1116391016605	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1116391016606	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391016607	inhibitor-cofactor binding pocket; inhibition site
1116391016608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391016609	catalytic residue [active]
1116391016610	PAS domain; Region: PAS; smart00091
1116391016611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391016612	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1116391016613	Walker A motif; other site
1116391016614	ATP binding site [chemical binding]; other site
1116391016615	Walker B motif; other site
1116391016616	arginine finger; other site
1116391016617	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1116391016618	active site
1116391016619	hypothetical protein; Provisional; Region: PRK09739
1116391016620	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1116391016621	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391016622	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391016623	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391016624	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016625	active site
1116391016626	phosphorylation site [posttranslational modification]
1116391016627	intermolecular recognition site; other site
1116391016628	dimerization interface [polypeptide binding]; other site
1116391016629	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016630	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016631	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016632	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016633	dimerization interface [polypeptide binding]; other site
1116391016634	Histidine kinase; Region: His_kinase; pfam06580
1116391016635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016636	ATP binding site [chemical binding]; other site
1116391016637	G-X-G motif; other site
1116391016638	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016639	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391016640	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016642	dimer interface [polypeptide binding]; other site
1116391016643	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391016644	ABC-ATPase subunit interface; other site
1116391016645	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391016646	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1116391016647	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016649	dimer interface [polypeptide binding]; other site
1116391016650	conserved gate region; other site
1116391016651	putative PBP binding loops; other site
1116391016652	ABC-ATPase subunit interface; other site
1116391016653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016654	dimer interface [polypeptide binding]; other site
1116391016655	conserved gate region; other site
1116391016656	putative PBP binding loops; other site
1116391016657	ABC-ATPase subunit interface; other site
1116391016658	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016659	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391016660	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391016661	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016662	dimerization interface [polypeptide binding]; other site
1116391016663	Histidine kinase; Region: His_kinase; pfam06580
1116391016664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016665	ATP binding site [chemical binding]; other site
1116391016666	Mg2+ binding site [ion binding]; other site
1116391016667	G-X-G motif; other site
1116391016668	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391016669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016670	active site
1116391016671	phosphorylation site [posttranslational modification]
1116391016672	intermolecular recognition site; other site
1116391016673	dimerization interface [polypeptide binding]; other site
1116391016674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016675	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1116391016676	putative FMN binding site [chemical binding]; other site
1116391016677	NADPH bind site [chemical binding]; other site
1116391016678	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1116391016679	putative FMN binding site [chemical binding]; other site
1116391016680	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1116391016681	YcaO-like family; Region: YcaO; pfam02624
1116391016682	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1116391016683	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
1116391016684	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1116391016685	DinB superfamily; Region: DinB_2; pfam12867
1116391016686	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1116391016687	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1116391016688	classical (c) SDRs; Region: SDR_c; cd05233
1116391016689	NAD(P) binding site [chemical binding]; other site
1116391016690	active site
1116391016691	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1116391016692	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1116391016693	active site 1 [active]
1116391016694	dimer interface [polypeptide binding]; other site
1116391016695	hexamer interface [polypeptide binding]; other site
1116391016696	active site 2 [active]
1116391016697	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391016698	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391016699	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391016700	dimerization interface [polypeptide binding]; other site
1116391016701	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016702	dimerization interface [polypeptide binding]; other site
1116391016703	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391016704	Histidine kinase; Region: His_kinase; pfam06580
1116391016705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016706	ATP binding site [chemical binding]; other site
1116391016707	Mg2+ binding site [ion binding]; other site
1116391016708	G-X-G motif; other site
1116391016709	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016710	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391016711	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016713	dimer interface [polypeptide binding]; other site
1116391016714	conserved gate region; other site
1116391016715	putative PBP binding loops; other site
1116391016716	ABC-ATPase subunit interface; other site
1116391016717	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391016718	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1116391016719	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391016720	sugar binding site [chemical binding]; other site
1116391016721	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391016722	sugar binding site [chemical binding]; other site
1116391016723	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
1116391016724	Cupin; Region: Cupin_1; smart00835
1116391016725	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391016726	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391016727	DNA binding site [nucleotide binding]
1116391016728	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1116391016729	Domain of unknown function (DUF336); Region: DUF336; cl01249
1116391016730	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
1116391016731	active site
1116391016732	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016733	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391016734	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391016735	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016737	dimer interface [polypeptide binding]; other site
1116391016738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391016739	ABC-ATPase subunit interface; other site
1116391016740	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391016741	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016742	dimer interface [polypeptide binding]; other site
1116391016743	conserved gate region; other site
1116391016744	ABC-ATPase subunit interface; other site
1116391016745	Cache domain; Region: Cache_1; pfam02743
1116391016746	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391016747	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391016748	metal binding site [ion binding]; metal-binding site
1116391016749	active site
1116391016750	I-site; other site
1116391016751	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1116391016752	NADP binding site [chemical binding]; other site
1116391016753	active site
1116391016754	steroid binding site; other site
1116391016755	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391016756	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391016757	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1116391016758	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391016759	putative ligand binding site [chemical binding]; other site
1116391016760	Cache domain; Region: Cache_1; pfam02743
1116391016761	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391016762	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391016763	dimerization interface [polypeptide binding]; other site
1116391016764	Histidine kinase; Region: His_kinase; pfam06580
1116391016765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016766	ATP binding site [chemical binding]; other site
1116391016767	Mg2+ binding site [ion binding]; other site
1116391016768	G-X-G motif; other site
1116391016769	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391016770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016771	active site
1116391016772	phosphorylation site [posttranslational modification]
1116391016773	intermolecular recognition site; other site
1116391016774	dimerization interface [polypeptide binding]; other site
1116391016775	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016776	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016777	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016778	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1116391016779	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391016780	putative ligand binding site [chemical binding]; other site
1116391016781	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391016782	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391016783	TM-ABC transporter signature motif; other site
1116391016784	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391016785	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391016786	Walker A/P-loop; other site
1116391016787	ATP binding site [chemical binding]; other site
1116391016788	Q-loop/lid; other site
1116391016789	ABC transporter signature motif; other site
1116391016790	Walker B; other site
1116391016791	D-loop; other site
1116391016792	H-loop/switch region; other site
1116391016793	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391016794	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391016795	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016796	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016797	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016798	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1116391016799	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1116391016800	metal binding site [ion binding]; metal-binding site
1116391016801	substrate binding pocket [chemical binding]; other site
1116391016802	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1116391016803	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1116391016804	NAD(P) binding site [chemical binding]; other site
1116391016805	catalytic residues [active]
1116391016806	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016807	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016808	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016809	dimer interface [polypeptide binding]; other site
1116391016810	conserved gate region; other site
1116391016811	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1116391016812	ABC-ATPase subunit interface; other site
1116391016813	nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769
1116391016814	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391016815	Walker A/P-loop; other site
1116391016816	ATP binding site [chemical binding]; other site
1116391016817	Q-loop/lid; other site
1116391016818	ABC transporter signature motif; other site
1116391016819	Walker B; other site
1116391016820	D-loop; other site
1116391016821	H-loop/switch region; other site
1116391016822	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1116391016823	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1116391016824	Walker A/P-loop; other site
1116391016825	ATP binding site [chemical binding]; other site
1116391016826	Q-loop/lid; other site
1116391016827	ABC transporter signature motif; other site
1116391016828	Walker B; other site
1116391016829	D-loop; other site
1116391016830	H-loop/switch region; other site
1116391016831	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1116391016832	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1116391016833	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016834	dimer interface [polypeptide binding]; other site
1116391016835	conserved gate region; other site
1116391016836	putative PBP binding loops; other site
1116391016837	ABC-ATPase subunit interface; other site
1116391016838	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
1116391016839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016840	dimer interface [polypeptide binding]; other site
1116391016841	conserved gate region; other site
1116391016842	putative PBP binding loops; other site
1116391016843	ABC-ATPase subunit interface; other site
1116391016844	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1116391016845	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1116391016846	substrate binding site [chemical binding]; other site
1116391016847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391016848	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391016849	putative substrate translocation pore; other site
1116391016850	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
1116391016851	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1116391016852	putative N- and C-terminal domain interface [polypeptide binding]; other site
1116391016853	putative active site [active]
1116391016854	MgATP binding site [chemical binding]; other site
1116391016855	catalytic site [active]
1116391016856	metal binding site [ion binding]; metal-binding site
1116391016857	putative carbohydrate binding site [chemical binding]; other site
1116391016858	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391016859	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391016860	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016861	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1116391016862	putative catalytic site [active]
1116391016863	putative metal binding site [ion binding]; other site
1116391016864	putative phosphate binding site [ion binding]; other site
1116391016865	Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615
1116391016866	putative sugar binding site [chemical binding]; other site
1116391016867	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1116391016868	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1116391016869	active site
1116391016870	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1116391016871	S-layer homology domain; Region: SLH; pfam00395
1116391016872	S-layer homology domain; Region: SLH; pfam00395
1116391016873	S-layer homology domain; Region: SLH; pfam00395
1116391016874	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1116391016875	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1116391016876	FtsX-like permease family; Region: FtsX; pfam02687
1116391016877	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1116391016878	FtsX-like permease family; Region: FtsX; pfam02687
1116391016879	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1116391016880	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1116391016881	Walker A/P-loop; other site
1116391016882	ATP binding site [chemical binding]; other site
1116391016883	Q-loop/lid; other site
1116391016884	ABC transporter signature motif; other site
1116391016885	Walker B; other site
1116391016886	D-loop; other site
1116391016887	H-loop/switch region; other site
1116391016888	sporulation sigma factor SigK; Reviewed; Region: PRK05803
1116391016889	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391016890	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391016891	DNA binding residues [nucleotide binding]
1116391016892	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391016893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391016894	dimer interface [polypeptide binding]; other site
1116391016895	conserved gate region; other site
1116391016896	ABC-ATPase subunit interface; other site
1116391016897	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1116391016898	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391016899	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391016900	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391016901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391016902	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1116391016903	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391016904	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1116391016905	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1116391016906	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391016907	putative DNA binding site [nucleotide binding]; other site
1116391016908	putative Zn2+ binding site [ion binding]; other site
1116391016909	AsnC family; Region: AsnC_trans_reg; pfam01037
1116391016910	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1116391016911	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1116391016912	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1116391016913	putative active site [active]
1116391016914	putative metal binding site [ion binding]; other site
1116391016915	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1116391016916	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1116391016917	generic binding surface I; other site
1116391016918	generic binding surface II; other site
1116391016919	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1116391016920	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391016921	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391016922	DNA binding residues [nucleotide binding]
1116391016923	dimerization interface [polypeptide binding]; other site
1116391016924	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1116391016925	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1116391016926	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1116391016927	acyl-activating enzyme (AAE) consensus motif; other site
1116391016928	putative AMP binding site [chemical binding]; other site
1116391016929	putative active site [active]
1116391016930	putative CoA binding site [chemical binding]; other site
1116391016931	Protein of unknown function (DUF429); Region: DUF429; cl12046
1116391016932	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
1116391016933	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1116391016934	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1116391016935	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1116391016936	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1116391016937	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1116391016938	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391016939	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391016940	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391016941	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1116391016942	Melibiase; Region: Melibiase; pfam02065
1116391016943	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1116391016944	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391016945	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391016946	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1116391016947	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1116391016948	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1116391016949	E3 interaction surface; other site
1116391016950	lipoyl attachment site [posttranslational modification]; other site
1116391016951	e3 binding domain; Region: E3_binding; pfam02817
1116391016952	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1116391016953	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1116391016954	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1116391016955	alpha subunit interface [polypeptide binding]; other site
1116391016956	TPP binding site [chemical binding]; other site
1116391016957	heterodimer interface [polypeptide binding]; other site
1116391016958	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1116391016959	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1116391016960	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1116391016961	TPP-binding site [chemical binding]; other site
1116391016962	heterodimer interface [polypeptide binding]; other site
1116391016963	tetramer interface [polypeptide binding]; other site
1116391016964	phosphorylation loop region [posttranslational modification]
1116391016965	Putative esterase; Region: Esterase; pfam00756
1116391016966	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1116391016967	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1116391016968	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
1116391016969	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
1116391016970	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391016971	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1116391016972	active site
1116391016973	metal binding site [ion binding]; metal-binding site
1116391016974	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
1116391016975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391016976	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391016977	active site
1116391016978	phosphorylation site [posttranslational modification]
1116391016979	intermolecular recognition site; other site
1116391016980	dimerization interface [polypeptide binding]; other site
1116391016981	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
1116391016982	GAF domain; Region: GAF_3; pfam13492
1116391016983	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878
1116391016984	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
1116391016985	NodB motif; other site
1116391016986	putative active site [active]
1116391016987	putative catalytic site [active]
1116391016988	putative Zn binding site [ion binding]; other site
1116391016989	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
1116391016990	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391016991	Predicted membrane protein [Function unknown]; Region: COG4267
1116391016992	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391016993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391016994	dimer interface [polypeptide binding]; other site
1116391016995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391016996	ATP binding site [chemical binding]; other site
1116391016997	Mg2+ binding site [ion binding]; other site
1116391016998	G-X-G motif; other site
1116391016999	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1116391017000	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1116391017001	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391017002	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391017003	dimerization interface [polypeptide binding]; other site
1116391017004	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391017005	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391017006	dimer interface [polypeptide binding]; other site
1116391017007	putative CheW interface [polypeptide binding]; other site
1116391017008	Peptidase family U32; Region: Peptidase_U32; pfam01136
1116391017009	YceG-like family; Region: YceG; pfam02618
1116391017010	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1116391017011	dimerization interface [polypeptide binding]; other site
1116391017012	hypothetical protein; Provisional; Region: PRK13678
1116391017013	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1116391017014	hypothetical protein; Provisional; Region: PRK05473
1116391017015	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1116391017016	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1116391017017	motif 1; other site
1116391017018	active site
1116391017019	motif 2; other site
1116391017020	motif 3; other site
1116391017021	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1116391017022	DHHA1 domain; Region: DHHA1; pfam02272
1116391017023	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338
1116391017024	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391017025	Spore germination protein; Region: Spore_permease; cl17796
1116391017026	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1116391017027	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1116391017028	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
1116391017029	PRC-barrel domain; Region: PRC; pfam05239
1116391017030	PRC-barrel domain; Region: PRC; pfam05239
1116391017031	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1116391017032	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1116391017033	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391017034	catalytic residue [active]
1116391017035	Predicted transcriptional regulator [Transcription]; Region: COG1959
1116391017036	Transcriptional regulator; Region: Rrf2; pfam02082
1116391017037	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1116391017038	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1116391017039	Ligand Binding Site [chemical binding]; other site
1116391017040	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1116391017041	Domain of unknown function DUF21; Region: DUF21; pfam01595
1116391017042	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1116391017043	Transporter associated domain; Region: CorC_HlyC; smart01091
1116391017044	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1116391017045	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1116391017046	recombination factor protein RarA; Reviewed; Region: PRK13342
1116391017047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391017048	Walker A motif; other site
1116391017049	ATP binding site [chemical binding]; other site
1116391017050	Walker B motif; other site
1116391017051	arginine finger; other site
1116391017052	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1116391017053	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1116391017054	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1116391017055	putative ATP binding site [chemical binding]; other site
1116391017056	putative substrate interface [chemical binding]; other site
1116391017057	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1116391017058	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1116391017059	dimer interface [polypeptide binding]; other site
1116391017060	anticodon binding site; other site
1116391017061	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1116391017062	homodimer interface [polypeptide binding]; other site
1116391017063	motif 1; other site
1116391017064	active site
1116391017065	motif 2; other site
1116391017066	GAD domain; Region: GAD; pfam02938
1116391017067	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1116391017068	active site
1116391017069	motif 3; other site
1116391017070	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1116391017071	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1116391017072	dimer interface [polypeptide binding]; other site
1116391017073	motif 1; other site
1116391017074	active site
1116391017075	motif 2; other site
1116391017076	motif 3; other site
1116391017077	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1116391017078	anticodon binding site; other site
1116391017079	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391017080	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1116391017081	putative active site [active]
1116391017082	dimerization interface [polypeptide binding]; other site
1116391017083	putative tRNAtyr binding site [nucleotide binding]; other site
1116391017084	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1116391017085	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391017086	Zn2+ binding site [ion binding]; other site
1116391017087	Mg2+ binding site [ion binding]; other site
1116391017088	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1116391017089	synthetase active site [active]
1116391017090	NTP binding site [chemical binding]; other site
1116391017091	metal binding site [ion binding]; metal-binding site
1116391017092	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1116391017093	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1116391017094	CotH protein; Region: CotH; pfam08757
1116391017095	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391017096	active site
1116391017097	Cation efflux family; Region: Cation_efflux; cl00316
1116391017098	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1116391017099	Protein export membrane protein; Region: SecD_SecF; pfam02355
1116391017100	protein-export membrane protein SecD; Region: secD; TIGR01129
1116391017101	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1116391017102	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1116391017103	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1116391017104	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1116391017105	Predicted membrane protein [Function unknown]; Region: COG2323
1116391017106	Preprotein translocase subunit; Region: YajC; pfam02699
1116391017107	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1116391017108	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1116391017109	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1116391017110	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1116391017111	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1116391017112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391017113	Walker A motif; other site
1116391017114	ATP binding site [chemical binding]; other site
1116391017115	Walker B motif; other site
1116391017116	arginine finger; other site
1116391017117	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1116391017118	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1116391017119	RuvA N terminal domain; Region: RuvA_N; pfam01330
1116391017120	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1116391017121	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1116391017122	active site
1116391017123	putative DNA-binding cleft [nucleotide binding]; other site
1116391017124	dimer interface [polypeptide binding]; other site
1116391017125	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1116391017126	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1116391017127	active site
1116391017128	BofC C-terminal domain; Region: BofC_C; pfam08955
1116391017129	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1116391017130	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1116391017131	Catalytic site [active]
1116391017132	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391017133	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1116391017134	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391017135	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1116391017136	MgtC family; Region: MgtC; pfam02308
1116391017137	prephenate dehydratase; Provisional; Region: PRK11898
1116391017138	Prephenate dehydratase; Region: PDT; pfam00800
1116391017139	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1116391017140	putative L-Phe binding site [chemical binding]; other site
1116391017141	homoserine kinase; Provisional; Region: PRK01212
1116391017142	homoserine dehydrogenase; Provisional; Region: PRK06349
1116391017143	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1116391017144	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1116391017145	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1116391017146	hypothetical protein; Provisional; Region: PRK04435
1116391017147	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1116391017148	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1116391017149	nudix motif; other site
1116391017150	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
1116391017151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391017152	Walker A/P-loop; other site
1116391017153	ATP binding site [chemical binding]; other site
1116391017154	Q-loop/lid; other site
1116391017155	ABC transporter signature motif; other site
1116391017156	Walker B; other site
1116391017157	D-loop; other site
1116391017158	H-loop/switch region; other site
1116391017159	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
1116391017160	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1116391017161	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1116391017162	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1116391017163	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1116391017164	[4Fe-4S] binding site [ion binding]; other site
1116391017165	molybdopterin cofactor binding site; other site
1116391017166	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1116391017167	molybdopterin cofactor binding site; other site
1116391017168	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1116391017169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017170	putative substrate translocation pore; other site
1116391017171	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1116391017172	GTP1/OBG; Region: GTP1_OBG; pfam01018
1116391017173	Obg GTPase; Region: Obg; cd01898
1116391017174	G1 box; other site
1116391017175	GTP/Mg2+ binding site [chemical binding]; other site
1116391017176	Switch I region; other site
1116391017177	G2 box; other site
1116391017178	G3 box; other site
1116391017179	Switch II region; other site
1116391017180	G4 box; other site
1116391017181	G5 box; other site
1116391017182	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1116391017183	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1116391017184	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1116391017185	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1116391017186	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1116391017187	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1116391017188	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1116391017189	homodimer interface [polypeptide binding]; other site
1116391017190	oligonucleotide binding site [chemical binding]; other site
1116391017191	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1116391017192	Peptidase family M50; Region: Peptidase_M50; pfam02163
1116391017193	active site
1116391017194	putative substrate binding region [chemical binding]; other site
1116391017195	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391017196	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1116391017197	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1116391017198	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1116391017199	Switch I; other site
1116391017200	Switch II; other site
1116391017201	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1116391017202	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1116391017203	rod shape-determining protein MreD; Region: MreD; cl01087
1116391017204	rod shape-determining protein MreC; Provisional; Region: PRK13922
1116391017205	rod shape-determining protein MreC; Region: MreC; pfam04085
1116391017206	rod shape-determining protein MreB; Provisional; Region: PRK13927
1116391017207	MreB and similar proteins; Region: MreB_like; cd10225
1116391017208	nucleotide binding site [chemical binding]; other site
1116391017209	Mg binding site [ion binding]; other site
1116391017210	putative protofilament interaction site [polypeptide binding]; other site
1116391017211	RodZ interaction site [polypeptide binding]; other site
1116391017212	hypothetical protein; Reviewed; Region: PRK00024
1116391017213	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1116391017214	MPN+ (JAMM) motif; other site
1116391017215	Zinc-binding site [ion binding]; other site
1116391017216	Maf-like protein; Provisional; Region: PRK14361
1116391017217	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1116391017218	active site
1116391017219	dimer interface [polypeptide binding]; other site
1116391017220	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1116391017221	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1116391017222	active site
1116391017223	metal binding site [ion binding]; metal-binding site
1116391017224	S-layer homology domain; Region: SLH; pfam00395
1116391017225	S-layer homology domain; Region: SLH; pfam00395
1116391017226	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1116391017227	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1116391017228	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1116391017229	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1116391017230	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1116391017231	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1116391017232	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1116391017233	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1116391017234	active site
1116391017235	HIGH motif; other site
1116391017236	nucleotide binding site [chemical binding]; other site
1116391017237	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1116391017238	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1116391017239	active site
1116391017240	KMSKS motif; other site
1116391017241	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1116391017242	tRNA binding surface [nucleotide binding]; other site
1116391017243	anticodon binding site; other site
1116391017244	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1116391017245	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391017246	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1116391017247	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1116391017248	active site
1116391017249	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391017250	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1116391017251	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391017252	inhibitor-cofactor binding pocket; inhibition site
1116391017253	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391017254	catalytic residue [active]
1116391017255	ferrochelatase; Provisional; Region: PRK12435
1116391017256	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1116391017257	C-terminal domain interface [polypeptide binding]; other site
1116391017258	active site
1116391017259	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1116391017260	active site
1116391017261	N-terminal domain interface [polypeptide binding]; other site
1116391017262	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1116391017263	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1116391017264	substrate binding site [chemical binding]; other site
1116391017265	active site
1116391017266	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1116391017267	dimer interface [polypeptide binding]; other site
1116391017268	active site
1116391017269	Schiff base residues; other site
1116391017270	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1116391017271	active site
1116391017272	SAM binding site [chemical binding]; other site
1116391017273	homodimer interface [polypeptide binding]; other site
1116391017274	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1116391017275	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1116391017276	active site
1116391017277	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1116391017278	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1116391017279	domain interfaces; other site
1116391017280	active site
1116391017281	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1116391017282	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1116391017283	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1116391017284	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1116391017285	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1116391017286	tRNA; other site
1116391017287	putative tRNA binding site [nucleotide binding]; other site
1116391017288	putative NADP binding site [chemical binding]; other site
1116391017289	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1116391017290	S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706
1116391017291	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1116391017292	G1 box; other site
1116391017293	GTP/Mg2+ binding site [chemical binding]; other site
1116391017294	Switch I region; other site
1116391017295	G2 box; other site
1116391017296	G3 box; other site
1116391017297	Switch II region; other site
1116391017298	G4 box; other site
1116391017299	G5 box; other site
1116391017300	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1116391017301	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1116391017302	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1116391017303	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391017304	Walker A motif; other site
1116391017305	ATP binding site [chemical binding]; other site
1116391017306	Walker B motif; other site
1116391017307	arginine finger; other site
1116391017308	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1116391017309	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1116391017310	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391017311	Walker A motif; other site
1116391017312	ATP binding site [chemical binding]; other site
1116391017313	Walker B motif; other site
1116391017314	arginine finger; other site
1116391017315	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1116391017316	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1116391017317	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1116391017318	active site
1116391017319	metal binding site [ion binding]; metal-binding site
1116391017320	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1116391017321	NodB motif; other site
1116391017322	putative active site [active]
1116391017323	putative catalytic site [active]
1116391017324	Zn binding site [ion binding]; other site
1116391017325	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1116391017326	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1116391017327	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1116391017328	Clp protease; Region: CLP_protease; pfam00574
1116391017329	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1116391017330	oligomer interface [polypeptide binding]; other site
1116391017331	active site residues [active]
1116391017332	trigger factor; Provisional; Region: tig; PRK01490
1116391017333	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1116391017334	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1116391017335	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391017336	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391017337	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391017338	Spore germination protein; Region: Spore_permease; cl17796
1116391017339	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1116391017340	active site
1116391017341	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1116391017342	dimer interface [polypeptide binding]; other site
1116391017343	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1116391017344	Ligand Binding Site [chemical binding]; other site
1116391017345	Molecular Tunnel; other site
1116391017346	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1116391017347	active site
1116391017348	dimerization interface [polypeptide binding]; other site
1116391017349	ribonuclease PH; Reviewed; Region: rph; PRK00173
1116391017350	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1116391017351	hexamer interface [polypeptide binding]; other site
1116391017352	active site
1116391017353	Sporulation and spore germination; Region: Germane; pfam10646
1116391017354	Spore germination protein [General function prediction only]; Region: COG5401
1116391017355	Sporulation and spore germination; Region: Germane; pfam10646
1116391017356	PAS domain S-box; Region: sensory_box; TIGR00229
1116391017357	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391017358	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391017359	metal binding site [ion binding]; metal-binding site
1116391017360	active site
1116391017361	I-site; other site
1116391017362	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1116391017363	tetramer interfaces [polypeptide binding]; other site
1116391017364	binuclear metal-binding site [ion binding]; other site
1116391017365	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391017366	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391017367	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391017368	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391017369	S-adenosylmethionine binding site [chemical binding]; other site
1116391017370	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1116391017371	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1116391017372	nucleotide binding site [chemical binding]; other site
1116391017373	DNA-sulfur modification-associated; Region: DndB; cl17621
1116391017374	DNA-sulfur modification-associated; Region: DndB; cl17621
1116391017375	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391017376	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017377	active site
1116391017378	phosphorylation site [posttranslational modification]
1116391017379	intermolecular recognition site; other site
1116391017380	dimerization interface [polypeptide binding]; other site
1116391017381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391017382	DNA binding residues [nucleotide binding]
1116391017383	dimerization interface [polypeptide binding]; other site
1116391017384	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391017385	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017386	ATP binding site [chemical binding]; other site
1116391017387	Mg2+ binding site [ion binding]; other site
1116391017388	G-X-G motif; other site
1116391017389	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
1116391017390	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1116391017391	putative hydrophobic ligand binding site [chemical binding]; other site
1116391017392	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1116391017393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017394	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1116391017395	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1116391017396	tetramer interface [polypeptide binding]; other site
1116391017397	heme binding pocket [chemical binding]; other site
1116391017398	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1116391017399	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391017400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391017401	DNA binding residues [nucleotide binding]
1116391017402	dimerization interface [polypeptide binding]; other site
1116391017403	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1116391017404	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1116391017405	transmembrane helices; other site
1116391017406	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1116391017407	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1116391017408	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1116391017409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391017410	S-adenosylmethionine binding site [chemical binding]; other site
1116391017411	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1116391017412	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1116391017413	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1116391017414	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1116391017415	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1116391017416	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1116391017417	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391017418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017419	active site
1116391017420	phosphorylation site [posttranslational modification]
1116391017421	intermolecular recognition site; other site
1116391017422	dimerization interface [polypeptide binding]; other site
1116391017423	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391017424	DNA binding residues [nucleotide binding]
1116391017425	dimerization interface [polypeptide binding]; other site
1116391017426	Histidine kinase; Region: HisKA_3; pfam07730
1116391017427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1116391017428	ATP binding site [chemical binding]; other site
1116391017429	Mg2+ binding site [ion binding]; other site
1116391017430	G-X-G motif; other site
1116391017431	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1116391017432	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1116391017433	dimer interface [polypeptide binding]; other site
1116391017434	active site
1116391017435	CoA binding pocket [chemical binding]; other site
1116391017436	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1116391017437	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1116391017438	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391017439	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1116391017440	Probable Catalytic site; other site
1116391017441	metal-binding site
1116391017442	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
1116391017443	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1116391017444	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1116391017445	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1116391017446	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1116391017447	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1116391017448	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1116391017449	Probable Catalytic site; other site
1116391017450	metal-binding site
1116391017451	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1116391017452	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1116391017453	active site
1116391017454	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391017455	active site
1116391017456	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391017457	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391017458	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1116391017459	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391017460	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391017461	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1116391017462	homotetramer interface [polypeptide binding]; other site
1116391017463	NADP-binding site; other site
1116391017464	substrate binding site [chemical binding]; other site
1116391017465	homodimer interface [polypeptide binding]; other site
1116391017466	active site
1116391017467	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1116391017468	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1116391017469	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1116391017470	NADP binding site [chemical binding]; other site
1116391017471	active site
1116391017472	putative substrate binding site [chemical binding]; other site
1116391017473	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1116391017474	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1116391017475	NAD binding site [chemical binding]; other site
1116391017476	substrate binding site [chemical binding]; other site
1116391017477	homodimer interface [polypeptide binding]; other site
1116391017478	active site
1116391017479	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391017480	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1116391017481	active site
1116391017482	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391017483	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391017484	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1116391017485	EcsC protein family; Region: EcsC; pfam12787
1116391017486	Cupin domain; Region: Cupin_2; pfam07883
1116391017487	O-Antigen ligase; Region: Wzy_C; pfam04932
1116391017488	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1116391017489	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391017490	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391017491	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391017492	MarR family; Region: MarR; pfam01047
1116391017493	MarR family; Region: MarR_2; cl17246
1116391017494	Pirin; Region: Pirin; pfam02678
1116391017495	Pirin-related protein [General function prediction only]; Region: COG1741
1116391017496	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
1116391017497	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1116391017498	Low-spin heme binding site [chemical binding]; other site
1116391017499	Subunit I/II interface [polypeptide binding]; other site
1116391017500	Putative Q-pathway; other site
1116391017501	Putative D-pathway homolog; other site
1116391017502	Putative alternate electron transfer pathway; other site
1116391017503	Putative water exit pathway; other site
1116391017504	Binuclear center (active site) [active]
1116391017505	Putative K-pathway homolog; other site
1116391017506	Putative proton exit pathway; other site
1116391017507	Subunit I/IIa interface [polypeptide binding]; other site
1116391017508	Electron transfer pathway; other site
1116391017509	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1116391017510	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1116391017511	Ion channel; Region: Ion_trans_2; pfam07885
1116391017512	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1116391017513	TrkA-N domain; Region: TrkA_N; pfam02254
1116391017514	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1116391017515	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1116391017516	Na binding site [ion binding]; other site
1116391017517	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1116391017518	Putative transcription activator [Transcription]; Region: TenA; COG0819
1116391017519	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1116391017520	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1116391017521	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1116391017522	Walker A/P-loop; other site
1116391017523	ATP binding site [chemical binding]; other site
1116391017524	Q-loop/lid; other site
1116391017525	ABC transporter signature motif; other site
1116391017526	Walker B; other site
1116391017527	D-loop; other site
1116391017528	H-loop/switch region; other site
1116391017529	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1116391017530	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1116391017531	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1116391017532	G1 box; other site
1116391017533	Walker A/P-loop; other site
1116391017534	GTP/Mg2+ binding site [chemical binding]; other site
1116391017535	ATP binding site [chemical binding]; other site
1116391017536	Q-loop/lid; other site
1116391017537	ABC transporter signature motif; other site
1116391017538	Walker B; other site
1116391017539	D-loop; other site
1116391017540	H-loop/switch region; other site
1116391017541	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1116391017542	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
1116391017543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017544	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391017545	putative substrate translocation pore; other site
1116391017546	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1116391017547	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391017548	Zn2+ binding site [ion binding]; other site
1116391017549	Mg2+ binding site [ion binding]; other site
1116391017550	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1116391017551	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391017552	catalytic residue [active]
1116391017553	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391017554	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1116391017555	Cupin domain; Region: Cupin_2; pfam07883
1116391017556	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017557	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391017558	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017559	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1116391017560	glutaminase A; Region: Gln_ase; TIGR03814
1116391017561	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391017562	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391017563	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391017564	TM-ABC transporter signature motif; other site
1116391017565	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1116391017566	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391017567	Walker A/P-loop; other site
1116391017568	ATP binding site [chemical binding]; other site
1116391017569	Q-loop/lid; other site
1116391017570	ABC transporter signature motif; other site
1116391017571	Walker B; other site
1116391017572	D-loop; other site
1116391017573	H-loop/switch region; other site
1116391017574	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391017575	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1116391017576	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1116391017577	putative ligand binding site [chemical binding]; other site
1116391017578	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1116391017579	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391017580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017581	active site
1116391017582	phosphorylation site [posttranslational modification]
1116391017583	intermolecular recognition site; other site
1116391017584	dimerization interface [polypeptide binding]; other site
1116391017585	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391017586	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017587	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391017588	Cache domain; Region: Cache_1; pfam02743
1116391017589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391017590	dimerization interface [polypeptide binding]; other site
1116391017591	Histidine kinase; Region: His_kinase; pfam06580
1116391017592	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017593	ATP binding site [chemical binding]; other site
1116391017594	Mg2+ binding site [ion binding]; other site
1116391017595	G-X-G motif; other site
1116391017596	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1116391017597	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391017598	ligand binding site [chemical binding]; other site
1116391017599	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1116391017600	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391017601	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391017602	putative DNA binding site [nucleotide binding]; other site
1116391017603	putative Zn2+ binding site [ion binding]; other site
1116391017604	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391017605	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391017606	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1116391017607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391017608	homodimer interface [polypeptide binding]; other site
1116391017609	catalytic residue [active]
1116391017610	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1116391017611	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391017612	NAD(P) binding site [chemical binding]; other site
1116391017613	active site
1116391017614	Helix-turn-helix domain; Region: HTH_31; pfam13560
1116391017615	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391017616	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391017617	S-layer homology domain; Region: SLH; pfam00395
1116391017618	S-layer homology domain; Region: SLH; pfam00395
1116391017619	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391017620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391017621	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391017622	MarR family; Region: MarR; pfam01047
1116391017623	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017624	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391017625	putative substrate translocation pore; other site
1116391017626	HTH-like domain; Region: HTH_21; pfam13276
1116391017627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391017628	Integrase core domain; Region: rve; pfam00665
1116391017629	Integrase core domain; Region: rve_3; pfam13683
1116391017630	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391017631	Transposase; Region: HTH_Tnp_1; cl17663
1116391017632	helicase 45; Provisional; Region: PTZ00424
1116391017633	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1116391017634	ATP binding site [chemical binding]; other site
1116391017635	Mg++ binding site [ion binding]; other site
1116391017636	motif III; other site
1116391017637	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391017638	nucleotide binding region [chemical binding]; other site
1116391017639	ATP-binding site [chemical binding]; other site
1116391017640	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1116391017641	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1116391017642	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1116391017643	active site
1116391017644	HIGH motif; other site
1116391017645	nucleotide binding site [chemical binding]; other site
1116391017646	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1116391017647	active site
1116391017648	KMSKS motif; other site
1116391017649	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1116391017650	tRNA binding surface [nucleotide binding]; other site
1116391017651	anticodon binding site; other site
1116391017652	Ferredoxin [Energy production and conversion]; Region: COG1146
1116391017653	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1116391017654	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1116391017655	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
1116391017656	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1116391017657	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391017658	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1116391017659	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
1116391017660	Spore germination protein; Region: Spore_permease; cl17796
1116391017661	Helix-turn-helix domain; Region: HTH_18; pfam12833
1116391017662	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017663	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1116391017664	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1116391017665	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1116391017666	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
1116391017667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391017668	active site
1116391017669	motif I; other site
1116391017670	motif II; other site
1116391017671	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1116391017672	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391017673	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1116391017674	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1116391017675	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1116391017676	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1116391017677	Catalytic site [active]
1116391017678	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1116391017679	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
1116391017680	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391017681	putative active site [active]
1116391017682	putative metal binding site [ion binding]; other site
1116391017683	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391017684	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017685	Spore germination protein; Region: Spore_permease; cl17796
1116391017686	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391017687	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391017688	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391017689	TSCPD domain; Region: TSCPD; pfam12637
1116391017690	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391017691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1116391017692	MOSC domain; Region: MOSC; pfam03473
1116391017693	3-alpha domain; Region: 3-alpha; pfam03475
1116391017694	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
1116391017695	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1116391017696	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391017697	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
1116391017698	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1116391017699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391017700	NAD(P) binding site [chemical binding]; other site
1116391017701	active site
1116391017702	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
1116391017703	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1116391017704	VanW like protein; Region: VanW; pfam04294
1116391017705	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
1116391017706	nudix motif; other site
1116391017707	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391017708	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1116391017709	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1116391017710	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1116391017711	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391017712	Walker A/P-loop; other site
1116391017713	ATP binding site [chemical binding]; other site
1116391017714	Q-loop/lid; other site
1116391017715	ABC transporter signature motif; other site
1116391017716	Walker B; other site
1116391017717	D-loop; other site
1116391017718	H-loop/switch region; other site
1116391017719	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391017720	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
1116391017721	serpin-like protein; Provisional; Region: PHA02660
1116391017722	reactive center loop; other site
1116391017723	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
1116391017724	serpin-like protein; Provisional; Region: PHA02660
1116391017725	reactive center loop; other site
1116391017726	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1116391017727	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1116391017728	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391017729	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017730	active site
1116391017731	phosphorylation site [posttranslational modification]
1116391017732	intermolecular recognition site; other site
1116391017733	dimerization interface [polypeptide binding]; other site
1116391017734	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391017735	DNA binding site [nucleotide binding]
1116391017736	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391017737	dimerization interface [polypeptide binding]; other site
1116391017738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391017739	dimer interface [polypeptide binding]; other site
1116391017740	phosphorylation site [posttranslational modification]
1116391017741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017742	ATP binding site [chemical binding]; other site
1116391017743	Mg2+ binding site [ion binding]; other site
1116391017744	G-X-G motif; other site
1116391017745	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1116391017746	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391017747	active site
1116391017748	motif I; other site
1116391017749	motif II; other site
1116391017750	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391017751	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1116391017752	active site
1116391017753	DinB superfamily; Region: DinB_2; pfam12867
1116391017754	metal-dependent hydrolase; Provisional; Region: PRK13291
1116391017755	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1116391017756	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391017757	DNA binding residues [nucleotide binding]
1116391017758	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1116391017759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017760	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391017761	putative substrate translocation pore; other site
1116391017762	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017763	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391017764	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391017765	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017766	putative substrate translocation pore; other site
1116391017767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017768	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391017769	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391017770	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391017771	dimerization interface [polypeptide binding]; other site
1116391017772	histidinol-phosphatase; Provisional; Region: PRK07328
1116391017773	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1116391017774	active site
1116391017775	dimer interface [polypeptide binding]; other site
1116391017776	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1116391017777	active site
1116391017778	catalytic triad [active]
1116391017779	oxyanion hole [active]
1116391017780	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1116391017781	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1116391017782	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1116391017783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017784	active site
1116391017785	phosphorylation site [posttranslational modification]
1116391017786	intermolecular recognition site; other site
1116391017787	dimerization interface [polypeptide binding]; other site
1116391017788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017789	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017790	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391017791	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391017792	dimerization interface [polypeptide binding]; other site
1116391017793	Histidine kinase; Region: His_kinase; pfam06580
1116391017794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017795	Mg2+ binding site [ion binding]; other site
1116391017796	G-X-G motif; other site
1116391017797	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391017798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391017799	dimer interface [polypeptide binding]; other site
1116391017800	conserved gate region; other site
1116391017801	putative PBP binding loops; other site
1116391017802	ABC-ATPase subunit interface; other site
1116391017803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391017804	dimer interface [polypeptide binding]; other site
1116391017805	conserved gate region; other site
1116391017806	putative PBP binding loops; other site
1116391017807	ABC-ATPase subunit interface; other site
1116391017808	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391017809	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391017810	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1116391017811	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1116391017812	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1116391017813	active site turn [active]
1116391017814	phosphorylation site [posttranslational modification]
1116391017815	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1116391017816	HPr interaction site; other site
1116391017817	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1116391017818	active site
1116391017819	phosphorylation site [posttranslational modification]
1116391017820	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1116391017821	CAT RNA binding domain; Region: CAT_RBD; smart01061
1116391017822	PRD domain; Region: PRD; pfam00874
1116391017823	PRD domain; Region: PRD; pfam00874
1116391017824	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391017825	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1116391017826	hypothetical protein; Validated; Region: PRK07668
1116391017827	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1116391017828	active site
1116391017829	catalytic site [active]
1116391017830	substrate binding site [chemical binding]; other site
1116391017831	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391017832	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391017833	S-layer homology domain; Region: SLH; pfam00395
1116391017834	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391017835	Histidine kinase; Region: HisKA_3; pfam07730
1116391017836	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017837	ATP binding site [chemical binding]; other site
1116391017838	Mg2+ binding site [ion binding]; other site
1116391017839	G-X-G motif; other site
1116391017840	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391017841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017842	active site
1116391017843	phosphorylation site [posttranslational modification]
1116391017844	intermolecular recognition site; other site
1116391017845	dimerization interface [polypeptide binding]; other site
1116391017846	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391017847	DNA binding residues [nucleotide binding]
1116391017848	dimerization interface [polypeptide binding]; other site
1116391017849	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391017850	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391017851	Beta-lactamase; Region: Beta-lactamase; pfam00144
1116391017852	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1116391017853	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391017854	Histidine kinase; Region: HisKA_3; pfam07730
1116391017855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017856	ATP binding site [chemical binding]; other site
1116391017857	Mg2+ binding site [ion binding]; other site
1116391017858	G-X-G motif; other site
1116391017859	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391017860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017861	active site
1116391017862	phosphorylation site [posttranslational modification]
1116391017863	intermolecular recognition site; other site
1116391017864	dimerization interface [polypeptide binding]; other site
1116391017865	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391017866	DNA binding residues [nucleotide binding]
1116391017867	dimerization interface [polypeptide binding]; other site
1116391017868	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1116391017869	heme-binding site [chemical binding]; other site
1116391017870	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391017871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391017872	dimer interface [polypeptide binding]; other site
1116391017873	putative CheW interface [polypeptide binding]; other site
1116391017874	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391017875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017876	active site
1116391017877	phosphorylation site [posttranslational modification]
1116391017878	intermolecular recognition site; other site
1116391017879	dimerization interface [polypeptide binding]; other site
1116391017880	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391017881	DNA binding site [nucleotide binding]
1116391017882	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1116391017883	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391017884	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391017885	dimer interface [polypeptide binding]; other site
1116391017886	phosphorylation site [posttranslational modification]
1116391017887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017888	ATP binding site [chemical binding]; other site
1116391017889	Mg2+ binding site [ion binding]; other site
1116391017890	G-X-G motif; other site
1116391017891	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1116391017892	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1116391017893	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391017894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391017895	S-adenosylmethionine binding site [chemical binding]; other site
1116391017896	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391017897	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391017898	putative active site [active]
1116391017899	heme pocket [chemical binding]; other site
1116391017900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391017901	dimer interface [polypeptide binding]; other site
1116391017902	phosphorylation site [posttranslational modification]
1116391017903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017904	ATP binding site [chemical binding]; other site
1116391017905	Mg2+ binding site [ion binding]; other site
1116391017906	G-X-G motif; other site
1116391017907	UDP-glucose 4-epimerase; Region: PLN02240
1116391017908	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1116391017909	NAD binding site [chemical binding]; other site
1116391017910	homodimer interface [polypeptide binding]; other site
1116391017911	active site
1116391017912	substrate binding site [chemical binding]; other site
1116391017913	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1116391017914	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1116391017915	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1116391017916	carbon starvation protein A; Provisional; Region: PRK15015
1116391017917	Carbon starvation protein CstA; Region: CstA; pfam02554
1116391017918	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1116391017919	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1116391017920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017921	active site
1116391017922	phosphorylation site [posttranslational modification]
1116391017923	intermolecular recognition site; other site
1116391017924	dimerization interface [polypeptide binding]; other site
1116391017925	LytTr DNA-binding domain; Region: LytTR; smart00850
1116391017926	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1116391017927	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1116391017928	Histidine kinase; Region: His_kinase; pfam06580
1116391017929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017930	ATP binding site [chemical binding]; other site
1116391017931	Mg2+ binding site [ion binding]; other site
1116391017932	G-X-G motif; other site
1116391017933	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
1116391017934	active site
1116391017935	metal binding site [ion binding]; metal-binding site
1116391017936	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1116391017937	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
1116391017938	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391017939	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1116391017940	putative active site [active]
1116391017941	putative metal binding site [ion binding]; other site
1116391017942	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1116391017943	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391017944	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391017945	putative substrate translocation pore; other site
1116391017946	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391017947	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391017948	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391017949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391017950	dimer interface [polypeptide binding]; other site
1116391017951	conserved gate region; other site
1116391017952	putative PBP binding loops; other site
1116391017953	ABC-ATPase subunit interface; other site
1116391017954	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391017955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391017956	dimer interface [polypeptide binding]; other site
1116391017957	conserved gate region; other site
1116391017958	putative PBP binding loops; other site
1116391017959	ABC-ATPase subunit interface; other site
1116391017960	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391017961	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391017962	dimerization interface [polypeptide binding]; other site
1116391017963	Histidine kinase; Region: His_kinase; pfam06580
1116391017964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391017965	ATP binding site [chemical binding]; other site
1116391017966	Mg2+ binding site [ion binding]; other site
1116391017967	G-X-G motif; other site
1116391017968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017969	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391017970	active site
1116391017971	phosphorylation site [posttranslational modification]
1116391017972	intermolecular recognition site; other site
1116391017973	dimerization interface [polypeptide binding]; other site
1116391017974	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391017975	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391017977	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1116391017978	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1116391017979	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
1116391017980	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1116391017981	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1116391017982	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1116391017983	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391017984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391017985	active site
1116391017986	phosphorylation site [posttranslational modification]
1116391017987	intermolecular recognition site; other site
1116391017988	dimerization interface [polypeptide binding]; other site
1116391017989	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391017990	DNA binding site [nucleotide binding]
1116391017991	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
1116391017992	homodimer interface [polypeptide binding]; other site
1116391017993	substrate-cofactor binding pocket; other site
1116391017994	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391017995	catalytic residue [active]
1116391017996	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1116391017997	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1116391017998	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1116391017999	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391018000	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391018001	non-specific DNA binding site [nucleotide binding]; other site
1116391018002	salt bridge; other site
1116391018003	sequence-specific DNA binding site [nucleotide binding]; other site
1116391018004	Anti-repressor SinI; Region: SinI; pfam08671
1116391018005	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391018006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391018007	non-specific DNA binding site [nucleotide binding]; other site
1116391018008	salt bridge; other site
1116391018009	sequence-specific DNA binding site [nucleotide binding]; other site
1116391018010	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1116391018011	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1116391018012	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1116391018013	Right handed beta helix region; Region: Beta_helix; pfam13229
1116391018014	Kelch motif; Region: Kelch_1; pfam01344
1116391018015	Galactose oxidase, central domain; Region: Kelch_3; cl02701
1116391018016	Kelch domain; Region: Kelch; smart00612
1116391018017	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
1116391018018	Kelch domain; Region: Kelch; smart00612
1116391018019	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1116391018020	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1116391018021	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1116391018022	trimer interface [polypeptide binding]; other site
1116391018023	active site
1116391018024	substrate binding site [chemical binding]; other site
1116391018025	CoA binding site [chemical binding]; other site
1116391018026	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1116391018027	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1116391018028	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1116391018029	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1116391018030	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1116391018031	Right handed beta helix region; Region: Beta_helix; pfam13229
1116391018032	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1116391018033	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1116391018034	active site
1116391018035	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391018036	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391018037	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1116391018038	active site
1116391018039	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1116391018040	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1116391018041	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1116391018042	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1116391018043	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1116391018044	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183
1116391018045	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391018046	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391018047	WzyE protein; Region: WzyE; cl11643
1116391018048	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1116391018049	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1116391018050	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391018051	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
1116391018052	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1116391018053	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1116391018054	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1116391018055	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1116391018056	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1116391018057	active site
1116391018058	tetramer interface; other site
1116391018059	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1116391018060	Chain length determinant protein; Region: Wzz; cl15801
1116391018061	putative glycosyl transferase; Provisional; Region: PRK10307
1116391018062	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1116391018063	putative acyl transferase; Provisional; Region: PRK10502
1116391018064	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1116391018065	putative trimer interface [polypeptide binding]; other site
1116391018066	putative active site [active]
1116391018067	putative substrate binding site [chemical binding]; other site
1116391018068	putative CoA binding site [chemical binding]; other site
1116391018069	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391018070	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391018071	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391018072	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391018073	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391018074	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391018075	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1116391018076	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1116391018077	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1116391018078	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1116391018079	NADP-binding site; other site
1116391018080	homotetramer interface [polypeptide binding]; other site
1116391018081	substrate binding site [chemical binding]; other site
1116391018082	homodimer interface [polypeptide binding]; other site
1116391018083	active site
1116391018084	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1116391018085	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1116391018086	NADP binding site [chemical binding]; other site
1116391018087	active site
1116391018088	putative substrate binding site [chemical binding]; other site
1116391018089	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1116391018090	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1116391018091	active site
1116391018092	tetramer interface; other site
1116391018093	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1116391018094	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1116391018095	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1116391018096	Chain length determinant protein; Region: Wzz; cl15801
1116391018097	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1116391018098	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391018099	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391018100	sequence-specific DNA binding site [nucleotide binding]; other site
1116391018101	salt bridge; other site
1116391018102	glutamine synthetase, type I; Region: GlnA; TIGR00653
1116391018103	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1116391018104	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1116391018105	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1116391018106	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1116391018107	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
1116391018108	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1116391018109	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1116391018110	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391018111	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391018112	dimerization interface [polypeptide binding]; other site
1116391018113	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391018114	dimer interface [polypeptide binding]; other site
1116391018115	phosphorylation site [posttranslational modification]
1116391018116	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391018117	ATP binding site [chemical binding]; other site
1116391018118	Mg2+ binding site [ion binding]; other site
1116391018119	G-X-G motif; other site
1116391018120	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391018121	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018122	active site
1116391018123	phosphorylation site [posttranslational modification]
1116391018124	intermolecular recognition site; other site
1116391018125	dimerization interface [polypeptide binding]; other site
1116391018126	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391018127	DNA binding site [nucleotide binding]
1116391018128	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391018129	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391018130	protein binding site [polypeptide binding]; other site
1116391018131	YugN-like family; Region: YugN; pfam08868
1116391018132	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1116391018133	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1116391018134	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1116391018135	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1116391018136	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1116391018137	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1116391018138	active site
1116391018139	dimer interface [polypeptide binding]; other site
1116391018140	motif 1; other site
1116391018141	motif 2; other site
1116391018142	motif 3; other site
1116391018143	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1116391018144	anticodon binding site; other site
1116391018145	YtxC-like family; Region: YtxC; pfam08812
1116391018146	Predicted membrane protein [Function unknown]; Region: COG3371
1116391018147	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391018148	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391018149	metal binding site [ion binding]; metal-binding site
1116391018150	active site
1116391018151	I-site; other site
1116391018152	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1116391018153	binding surface
1116391018154	TPR motif; other site
1116391018155	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1116391018156	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1116391018157	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391018158	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391018159	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
1116391018160	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391018161	FeS/SAM binding site; other site
1116391018162	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1116391018163	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1116391018164	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1116391018165	homodimer interface [polypeptide binding]; other site
1116391018166	substrate-cofactor binding pocket; other site
1116391018167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018168	catalytic residue [active]
1116391018169	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1116391018170	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1116391018171	proposed active site lysine [active]
1116391018172	conserved cys residue [active]
1116391018173	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1116391018174	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
1116391018175	oligomer interface [polypeptide binding]; other site
1116391018176	metal binding site [ion binding]; metal-binding site
1116391018177	metal binding site [ion binding]; metal-binding site
1116391018178	putative Cl binding site [ion binding]; other site
1116391018179	aspartate ring; other site
1116391018180	basic sphincter; other site
1116391018181	hydrophobic gate; other site
1116391018182	periplasmic entrance; other site
1116391018183	HRDC domain; Region: HRDC; pfam00570
1116391018184	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1116391018185	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1116391018186	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1116391018187	Predicted transcriptional regulator [Transcription]; Region: COG4189
1116391018188	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391018189	putative DNA binding site [nucleotide binding]; other site
1116391018190	dimerization interface [polypeptide binding]; other site
1116391018191	putative Zn2+ binding site [ion binding]; other site
1116391018192	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1116391018193	5'-3' exonuclease; Region: 53EXOc; smart00475
1116391018194	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1116391018195	active site
1116391018196	metal binding site 1 [ion binding]; metal-binding site
1116391018197	putative 5' ssDNA interaction site; other site
1116391018198	metal binding site 3; metal-binding site
1116391018199	metal binding site 2 [ion binding]; metal-binding site
1116391018200	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1116391018201	putative DNA binding site [nucleotide binding]; other site
1116391018202	putative metal binding site [ion binding]; other site
1116391018203	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018204	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391018205	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018206	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391018207	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391018208	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391018209	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391018210	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391018211	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391018212	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
1116391018213	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391018214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018215	homodimer interface [polypeptide binding]; other site
1116391018216	catalytic residue [active]
1116391018217	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1116391018218	Peptidase family M50; Region: Peptidase_M50; pfam02163
1116391018219	active site
1116391018220	putative substrate binding region [chemical binding]; other site
1116391018221	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1116391018222	ArsC family; Region: ArsC; pfam03960
1116391018223	putative ArsC-like catalytic residues; other site
1116391018224	putative TRX-like catalytic residues [active]
1116391018225	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1116391018226	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1116391018227	putative active site [active]
1116391018228	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1116391018229	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391018230	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1116391018231	active site
1116391018232	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1116391018233	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1116391018234	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391018235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018236	homodimer interface [polypeptide binding]; other site
1116391018237	catalytic residue [active]
1116391018238	cobyric acid synthase; Provisional; Region: PRK00784
1116391018239	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1116391018240	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1116391018241	catalytic triad [active]
1116391018242	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1116391018243	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1116391018244	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
1116391018245	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1116391018246	homotrimer interface [polypeptide binding]; other site
1116391018247	Walker A motif; other site
1116391018248	GTP binding site [chemical binding]; other site
1116391018249	Walker B motif; other site
1116391018250	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1116391018251	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1116391018252	putative dimer interface [polypeptide binding]; other site
1116391018253	active site pocket [active]
1116391018254	putative cataytic base [active]
1116391018255	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391018256	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391018257	ABC-ATPase subunit  interface; other site
1116391018258	dimer interface [polypeptide binding]; other site
1116391018259	putative PBP binding regions; other site
1116391018260	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1116391018261	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1116391018262	putative binding site residues; other site
1116391018263	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1116391018264	hypothetical protein; Validated; Region: PRK07682
1116391018265	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391018266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018267	homodimer interface [polypeptide binding]; other site
1116391018268	catalytic residue [active]
1116391018269	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1116391018270	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1116391018271	AsnC family; Region: AsnC_trans_reg; pfam01037
1116391018272	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1116391018273	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1116391018274	dimer interface [polypeptide binding]; other site
1116391018275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018276	catalytic residue [active]
1116391018277	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391018278	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391018279	putative substrate translocation pore; other site
1116391018280	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1116391018281	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1116391018282	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1116391018283	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1116391018284	MutS domain III; Region: MutS_III; pfam05192
1116391018285	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1116391018286	Walker A/P-loop; other site
1116391018287	ATP binding site [chemical binding]; other site
1116391018288	Q-loop/lid; other site
1116391018289	ABC transporter signature motif; other site
1116391018290	Walker B; other site
1116391018291	D-loop; other site
1116391018292	H-loop/switch region; other site
1116391018293	Smr domain; Region: Smr; pfam01713
1116391018294	Membrane protein of unknown function; Region: DUF360; pfam04020
1116391018295	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1116391018296	classical (c) SDRs; Region: SDR_c; cd05233
1116391018297	NAD(P) binding site [chemical binding]; other site
1116391018298	active site
1116391018299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391018300	DNA-binding site [nucleotide binding]; DNA binding site
1116391018301	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391018302	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391018303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018304	homodimer interface [polypeptide binding]; other site
1116391018305	catalytic residue [active]
1116391018306	Colicin V production protein; Region: Colicin_V; pfam02674
1116391018307	Cell division protein ZapA; Region: ZapA; cl01146
1116391018308	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1116391018309	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1116391018310	putative tRNA-binding site [nucleotide binding]; other site
1116391018311	B3/4 domain; Region: B3_4; pfam03483
1116391018312	tRNA synthetase B5 domain; Region: B5; pfam03484
1116391018313	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1116391018314	dimer interface [polypeptide binding]; other site
1116391018315	motif 1; other site
1116391018316	motif 3; other site
1116391018317	motif 2; other site
1116391018318	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1116391018319	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1116391018320	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1116391018321	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1116391018322	dimer interface [polypeptide binding]; other site
1116391018323	motif 1; other site
1116391018324	active site
1116391018325	motif 2; other site
1116391018326	motif 3; other site
1116391018327	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
1116391018328	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1116391018329	Ferritin-like domain; Region: Ferritin; pfam00210
1116391018330	ferroxidase diiron center [ion binding]; other site
1116391018331	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1116391018332	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1116391018333	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391018334	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391018335	DNA binding residues [nucleotide binding]
1116391018336	SnoaL-like domain; Region: SnoaL_2; pfam12680
1116391018337	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1116391018338	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1116391018339	PAS fold; Region: PAS; pfam00989
1116391018340	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391018341	putative active site [active]
1116391018342	heme pocket [chemical binding]; other site
1116391018343	PAS domain S-box; Region: sensory_box; TIGR00229
1116391018344	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391018345	putative active site [active]
1116391018346	heme pocket [chemical binding]; other site
1116391018347	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391018348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391018349	metal binding site [ion binding]; metal-binding site
1116391018350	active site
1116391018351	I-site; other site
1116391018352	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1116391018353	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1116391018354	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1116391018355	catalytic triad [active]
1116391018356	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1116391018357	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1116391018358	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1116391018359	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1116391018360	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1116391018361	active site
1116391018362	SAM binding site [chemical binding]; other site
1116391018363	homodimer interface [polypeptide binding]; other site
1116391018364	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1116391018365	active site
1116391018366	SAM binding site [chemical binding]; other site
1116391018367	homodimer interface [polypeptide binding]; other site
1116391018368	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1116391018369	active site
1116391018370	putative homodimer interface [polypeptide binding]; other site
1116391018371	SAM binding site [chemical binding]; other site
1116391018372	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1116391018373	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
1116391018374	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1116391018375	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
1116391018376	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1116391018377	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1116391018378	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1116391018379	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1116391018380	putative active site [active]
1116391018381	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1116391018382	putative active site [active]
1116391018383	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1116391018384	active site
1116391018385	SAM binding site [chemical binding]; other site
1116391018386	homodimer interface [polypeptide binding]; other site
1116391018387	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1116391018388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1116391018389	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391018390	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391018391	active site
1116391018392	catalytic tetrad [active]
1116391018393	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391018394	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391018395	metal binding site [ion binding]; metal-binding site
1116391018396	active site
1116391018397	I-site; other site
1116391018398	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391018399	CopC domain; Region: CopC; pfam04234
1116391018400	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088
1116391018401	ATP cone domain; Region: ATP-cone; pfam03477
1116391018402	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1116391018403	active site
1116391018404	dimer interface [polypeptide binding]; other site
1116391018405	catalytic residues [active]
1116391018406	effector binding site; other site
1116391018407	R2 peptide binding site; other site
1116391018408	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391018409	Transposase; Region: HTH_Tnp_1; cl17663
1116391018410	HTH-like domain; Region: HTH_21; pfam13276
1116391018411	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391018412	Integrase core domain; Region: rve; pfam00665
1116391018413	Integrase core domain; Region: rve_3; pfam13683
1116391018414	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1116391018415	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1116391018416	dimer interface [polypeptide binding]; other site
1116391018417	putative radical transfer pathway; other site
1116391018418	diiron center [ion binding]; other site
1116391018419	tyrosyl radical; other site
1116391018420	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1116391018421	putative binding surface; other site
1116391018422	active site
1116391018423	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391018424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018425	active site
1116391018426	phosphorylation site [posttranslational modification]
1116391018427	intermolecular recognition site; other site
1116391018428	dimerization interface [polypeptide binding]; other site
1116391018429	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391018430	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391018431	metal binding site [ion binding]; metal-binding site
1116391018432	active site
1116391018433	I-site; other site
1116391018434	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391018435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018436	active site
1116391018437	phosphorylation site [posttranslational modification]
1116391018438	intermolecular recognition site; other site
1116391018439	dimerization interface [polypeptide binding]; other site
1116391018440	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1116391018441	putative active site pocket [active]
1116391018442	dimerization interface [polypeptide binding]; other site
1116391018443	putative catalytic residue [active]
1116391018444	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
1116391018445	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1116391018446	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1116391018447	putative active site [active]
1116391018448	Mor transcription activator family; Region: Mor; cl02360
1116391018449	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1116391018450	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1116391018451	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
1116391018452	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1116391018453	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1116391018454	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1116391018455	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1116391018456	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391018457	active site
1116391018458	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1116391018459	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1116391018460	active site
1116391018461	metal binding site [ion binding]; metal-binding site
1116391018462	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1116391018463	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1116391018464	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391018465	substrate binding pocket [chemical binding]; other site
1116391018466	membrane-bound complex binding site; other site
1116391018467	hinge residues; other site
1116391018468	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1116391018469	threonine synthase; Validated; Region: PRK06260
1116391018470	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1116391018471	homodimer interface [polypeptide binding]; other site
1116391018472	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018473	catalytic residue [active]
1116391018474	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1116391018475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1116391018476	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1116391018477	dimerization interface [polypeptide binding]; other site
1116391018478	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1116391018479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391018480	dimer interface [polypeptide binding]; other site
1116391018481	conserved gate region; other site
1116391018482	ABC-ATPase subunit interface; other site
1116391018483	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1116391018484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391018485	dimer interface [polypeptide binding]; other site
1116391018486	conserved gate region; other site
1116391018487	ABC-ATPase subunit interface; other site
1116391018488	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1116391018489	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1116391018490	Walker A/P-loop; other site
1116391018491	ATP binding site [chemical binding]; other site
1116391018492	Q-loop/lid; other site
1116391018493	ABC transporter signature motif; other site
1116391018494	Walker B; other site
1116391018495	D-loop; other site
1116391018496	H-loop/switch region; other site
1116391018497	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1116391018498	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1116391018499	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1116391018500	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391018501	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1116391018502	Walker A/P-loop; other site
1116391018503	ATP binding site [chemical binding]; other site
1116391018504	Q-loop/lid; other site
1116391018505	ABC transporter signature motif; other site
1116391018506	Walker B; other site
1116391018507	D-loop; other site
1116391018508	H-loop/switch region; other site
1116391018509	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1116391018510	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1116391018511	active site
1116391018512	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391018513	3D domain; Region: 3D; cl01439
1116391018514	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1116391018515	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1116391018516	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1116391018517	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391018518	putative active site [active]
1116391018519	heme pocket [chemical binding]; other site
1116391018520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391018521	ATP binding site [chemical binding]; other site
1116391018522	Mg2+ binding site [ion binding]; other site
1116391018523	G-X-G motif; other site
1116391018524	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1116391018525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018526	active site
1116391018527	phosphorylation site [posttranslational modification]
1116391018528	intermolecular recognition site; other site
1116391018529	dimerization interface [polypeptide binding]; other site
1116391018530	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1116391018531	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1116391018532	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1116391018533	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1116391018534	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391018535	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1116391018536	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1116391018537	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391018538	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391018539	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018541	lysine transporter; Provisional; Region: PRK10836
1116391018542	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1116391018543	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1116391018544	Walker A/P-loop; other site
1116391018545	ATP binding site [chemical binding]; other site
1116391018546	Q-loop/lid; other site
1116391018547	ABC transporter signature motif; other site
1116391018548	Walker B; other site
1116391018549	D-loop; other site
1116391018550	H-loop/switch region; other site
1116391018551	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1116391018552	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1116391018553	hypothetical protein; Provisional; Region: PRK06185
1116391018554	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391018555	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1116391018556	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1116391018557	catalytic site [active]
1116391018558	PrcB C-terminal; Region: PrcB_C; pfam14343
1116391018559	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1116391018560	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391018561	putative ligand binding site [chemical binding]; other site
1116391018562	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391018563	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391018564	Walker A/P-loop; other site
1116391018565	ATP binding site [chemical binding]; other site
1116391018566	Q-loop/lid; other site
1116391018567	ABC transporter signature motif; other site
1116391018568	Walker B; other site
1116391018569	D-loop; other site
1116391018570	H-loop/switch region; other site
1116391018571	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391018572	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391018573	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391018574	TM-ABC transporter signature motif; other site
1116391018575	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
1116391018576	putative active site [active]
1116391018577	putative catalytic site [active]
1116391018578	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
1116391018579	PLD-like domain; Region: PLDc_2; pfam13091
1116391018580	putative active site [active]
1116391018581	putative catalytic site [active]
1116391018582	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391018583	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391018584	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391018585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391018586	dimer interface [polypeptide binding]; other site
1116391018587	conserved gate region; other site
1116391018588	putative PBP binding loops; other site
1116391018589	ABC-ATPase subunit interface; other site
1116391018590	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391018591	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391018592	dimer interface [polypeptide binding]; other site
1116391018593	conserved gate region; other site
1116391018594	putative PBP binding loops; other site
1116391018595	ABC-ATPase subunit interface; other site
1116391018596	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391018597	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391018598	substrate binding pocket [chemical binding]; other site
1116391018599	membrane-bound complex binding site; other site
1116391018600	hinge residues; other site
1116391018601	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391018602	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391018603	Walker A/P-loop; other site
1116391018604	ATP binding site [chemical binding]; other site
1116391018605	Q-loop/lid; other site
1116391018606	ABC transporter signature motif; other site
1116391018607	Walker B; other site
1116391018608	D-loop; other site
1116391018609	H-loop/switch region; other site
1116391018610	S-layer homology domain; Region: SLH; pfam00395
1116391018611	Protein of unknown function (DUF2845); Region: DUF2845; pfam11006
1116391018612	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1116391018613	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1116391018614	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1116391018615	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1116391018616	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1116391018617	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1116391018618	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1116391018619	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391018620	putative active site [active]
1116391018621	heme pocket [chemical binding]; other site
1116391018622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391018623	dimer interface [polypeptide binding]; other site
1116391018624	phosphorylation site [posttranslational modification]
1116391018625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391018626	ATP binding site [chemical binding]; other site
1116391018627	Mg2+ binding site [ion binding]; other site
1116391018628	G-X-G motif; other site
1116391018629	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
1116391018630	Protein of unknown function (DUF458); Region: DUF458; pfam04308
1116391018631	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1116391018632	active site
1116391018633	zinc binding site [ion binding]; other site
1116391018634	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391018635	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391018636	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391018637	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1116391018638	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391018639	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391018640	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391018641	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391018642	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391018643	dimer interface [polypeptide binding]; other site
1116391018644	conserved gate region; other site
1116391018645	putative PBP binding loops; other site
1116391018646	ABC-ATPase subunit interface; other site
1116391018647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391018648	dimer interface [polypeptide binding]; other site
1116391018649	conserved gate region; other site
1116391018650	putative PBP binding loops; other site
1116391018651	ABC-ATPase subunit interface; other site
1116391018652	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391018653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391018654	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391018655	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018656	active site
1116391018657	phosphorylation site [posttranslational modification]
1116391018658	intermolecular recognition site; other site
1116391018659	dimerization interface [polypeptide binding]; other site
1116391018660	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391018661	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018662	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391018663	Histidine kinase; Region: His_kinase; pfam06580
1116391018664	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391018665	ATP binding site [chemical binding]; other site
1116391018666	Mg2+ binding site [ion binding]; other site
1116391018667	G-X-G motif; other site
1116391018668	YheO-like PAS domain; Region: PAS_6; pfam08348
1116391018669	HTH domain; Region: HTH_22; pfam13309
1116391018670	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1116391018671	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1116391018672	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1116391018673	catalytic residue [active]
1116391018674	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1116391018675	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1116391018676	active site
1116391018677	putative substrate binding pocket [chemical binding]; other site
1116391018678	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1116391018679	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1116391018680	homotrimer interaction site [polypeptide binding]; other site
1116391018681	putative active site [active]
1116391018682	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391018683	Coenzyme A binding pocket [chemical binding]; other site
1116391018684	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1116391018685	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391018686	Phosphotransferase enzyme family; Region: APH; pfam01636
1116391018687	substrate binding site [chemical binding]; other site
1116391018688	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1116391018689	Phosphotransferase enzyme family; Region: APH; pfam01636
1116391018690	active site
1116391018691	substrate binding site [chemical binding]; other site
1116391018692	ATP binding site [chemical binding]; other site
1116391018693	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1116391018694	putative active site [active]
1116391018695	putative metal binding site [ion binding]; other site
1116391018696	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391018697	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391018698	FAD binding domain; Region: FAD_binding_3; pfam01494
1116391018699	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1116391018700	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1116391018701	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391018702	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1116391018703	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1116391018704	active site
1116391018705	non-prolyl cis peptide bond; other site
1116391018706	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1116391018707	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1116391018708	Walker A/P-loop; other site
1116391018709	ATP binding site [chemical binding]; other site
1116391018710	Q-loop/lid; other site
1116391018711	ABC transporter signature motif; other site
1116391018712	Walker B; other site
1116391018713	D-loop; other site
1116391018714	H-loop/switch region; other site
1116391018715	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1116391018716	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1116391018717	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1116391018718	dimer interface [polypeptide binding]; other site
1116391018719	FMN binding site [chemical binding]; other site
1116391018720	NADPH bind site [chemical binding]; other site
1116391018721	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391018722	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1116391018723	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1116391018724	active site
1116391018725	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1116391018726	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1116391018727	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391018728	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391018729	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1116391018730	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391018731	Fn3 associated; Region: Fn3_assoc; pfam13287
1116391018732	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391018733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018734	active site
1116391018735	phosphorylation site [posttranslational modification]
1116391018736	intermolecular recognition site; other site
1116391018737	dimerization interface [polypeptide binding]; other site
1116391018738	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391018739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018740	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018741	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391018742	dimerization interface [polypeptide binding]; other site
1116391018743	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391018744	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391018745	dimer interface [polypeptide binding]; other site
1116391018746	putative CheW interface [polypeptide binding]; other site
1116391018747	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391018748	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391018749	TM-ABC transporter signature motif; other site
1116391018750	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391018751	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391018752	Walker A/P-loop; other site
1116391018753	ATP binding site [chemical binding]; other site
1116391018754	Q-loop/lid; other site
1116391018755	ABC transporter signature motif; other site
1116391018756	Walker B; other site
1116391018757	D-loop; other site
1116391018758	H-loop/switch region; other site
1116391018759	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391018760	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
1116391018761	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1116391018762	ligand binding site [chemical binding]; other site
1116391018763	calcium binding site [ion binding]; other site
1116391018764	putative transposase OrfB; Reviewed; Region: PHA02517
1116391018765	HTH-like domain; Region: HTH_21; pfam13276
1116391018766	Integrase core domain; Region: rve; pfam00665
1116391018767	Integrase core domain; Region: rve_3; pfam13683
1116391018768	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391018769	Transposase; Region: HTH_Tnp_1; cl17663
1116391018770	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1116391018771	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1116391018772	putative ligand binding site [chemical binding]; other site
1116391018773	Cache domain; Region: Cache_1; pfam02743
1116391018774	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391018775	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391018776	dimerization interface [polypeptide binding]; other site
1116391018777	Histidine kinase; Region: His_kinase; pfam06580
1116391018778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391018779	ATP binding site [chemical binding]; other site
1116391018780	Mg2+ binding site [ion binding]; other site
1116391018781	G-X-G motif; other site
1116391018782	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391018783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018784	active site
1116391018785	phosphorylation site [posttranslational modification]
1116391018786	intermolecular recognition site; other site
1116391018787	dimerization interface [polypeptide binding]; other site
1116391018788	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391018789	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018790	TIGR02452 family protein; Region: TIGR02452
1116391018791	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
1116391018792	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1116391018793	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1116391018794	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1116391018795	active site
1116391018796	nucleotide binding site [chemical binding]; other site
1116391018797	HIGH motif; other site
1116391018798	KMSKS motif; other site
1116391018799	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1116391018800	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
1116391018801	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1116391018802	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1116391018803	Leucine rich repeat; Region: LRR_8; pfam13855
1116391018804	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391018805	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1116391018806	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391018807	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1116391018808	Walker A motif; other site
1116391018809	ATP binding site [chemical binding]; other site
1116391018810	Walker B motif; other site
1116391018811	arginine finger; other site
1116391018812	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1116391018813	tellurium resistance terB-like protein; Region: terB_like; cd07177
1116391018814	metal binding site [ion binding]; metal-binding site
1116391018815	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1116391018816	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1116391018817	CGNR zinc finger; Region: zf-CGNR; pfam11706
1116391018818	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1116391018819	phosphate binding site [ion binding]; other site
1116391018820	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1116391018821	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391018822	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1116391018823	DNA binding residues [nucleotide binding]
1116391018824	Predicted transcriptional regulators [Transcription]; Region: COG1695
1116391018825	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1116391018826	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1116391018827	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1116391018828	Heat induced stress protein YflT; Region: YflT; pfam11181
1116391018829	conserved domain; Region: TIGR02271
1116391018830	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391018831	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391018832	protein binding site [polypeptide binding]; other site
1116391018833	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391018834	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391018835	ABC-ATPase subunit  interface; other site
1116391018836	dimer interface [polypeptide binding]; other site
1116391018837	putative PBP binding regions; other site
1116391018838	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391018839	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391018840	ABC-ATPase subunit  interface; other site
1116391018841	dimer interface [polypeptide binding]; other site
1116391018842	putative PBP binding regions; other site
1116391018843	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1116391018844	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391018845	intersubunit interface [polypeptide binding]; other site
1116391018846	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391018847	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391018848	metal binding site [ion binding]; metal-binding site
1116391018849	active site
1116391018850	I-site; other site
1116391018851	Fic family protein [Function unknown]; Region: COG3177
1116391018852	Fic/DOC family; Region: Fic; pfam02661
1116391018853	MarR family; Region: MarR_2; cl17246
1116391018854	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1116391018855	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1116391018856	P loop; other site
1116391018857	Nucleotide binding site [chemical binding]; other site
1116391018858	DTAP/Switch II; other site
1116391018859	Switch I; other site
1116391018860	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1116391018861	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1116391018862	Chorismate mutase type II; Region: CM_2; cl00693
1116391018863	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1116391018864	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1116391018865	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1116391018866	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1116391018867	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391018868	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391018869	active site
1116391018870	catalytic tetrad [active]
1116391018871	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391018872	Coenzyme A binding pocket [chemical binding]; other site
1116391018873	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391018874	Coenzyme A binding pocket [chemical binding]; other site
1116391018875	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1116391018876	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1116391018877	dimer interface [polypeptide binding]; other site
1116391018878	active site
1116391018879	metal binding site [ion binding]; metal-binding site
1116391018880	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1116391018881	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1116391018882	substrate binding site; other site
1116391018883	dimerization interface; other site
1116391018884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391018885	Coenzyme A binding pocket [chemical binding]; other site
1116391018886	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1116391018887	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391018888	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391018889	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391018890	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1116391018891	substrate binding site [chemical binding]; other site
1116391018892	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1116391018893	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1116391018894	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1116391018895	Competence protein J (ComJ); Region: ComJ; pfam11033
1116391018896	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391018897	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
1116391018898	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391018899	Interdomain contacts; other site
1116391018900	Cytokine receptor motif; other site
1116391018901	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391018902	Interdomain contacts; other site
1116391018903	Cytokine receptor motif; other site
1116391018904	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391018905	dockerin binding interface; other site
1116391018906	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
1116391018907	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1116391018908	putative NAD(P) binding site [chemical binding]; other site
1116391018909	substrate binding site [chemical binding]; other site
1116391018910	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1116391018911	iron-sulfur cluster [ion binding]; other site
1116391018912	[2Fe-2S] cluster binding site [ion binding]; other site
1116391018913	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1116391018914	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1116391018915	conserved cys residue [active]
1116391018916	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391018917	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391018918	Metal-binding active site; metal-binding site
1116391018919	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1116391018920	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391018921	acyl carrier protein; Provisional; Region: PRK07639
1116391018922	acyl-CoA synthetase; Validated; Region: PRK08308
1116391018923	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1116391018924	acyl-activating enzyme (AAE) consensus motif; other site
1116391018925	AMP binding site [chemical binding]; other site
1116391018926	active site
1116391018927	CoA binding site [chemical binding]; other site
1116391018928	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1116391018929	IucA / IucC family; Region: IucA_IucC; pfam04183
1116391018930	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1116391018931	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391018932	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1116391018933	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1116391018934	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1116391018935	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
1116391018936	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1116391018937	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1116391018938	IucA / IucC family; Region: IucA_IucC; pfam04183
1116391018939	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1116391018940	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1116391018941	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018942	catalytic residue [active]
1116391018943	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
1116391018944	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391018945	inhibitor-cofactor binding pocket; inhibition site
1116391018946	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391018947	catalytic residue [active]
1116391018948	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1116391018949	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391018950	siderophore binding site; other site
1116391018951	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391018952	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1116391018953	Walker A/P-loop; other site
1116391018954	ATP binding site [chemical binding]; other site
1116391018955	Q-loop/lid; other site
1116391018956	ABC transporter signature motif; other site
1116391018957	Walker B; other site
1116391018958	D-loop; other site
1116391018959	H-loop/switch region; other site
1116391018960	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
1116391018961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391018962	DNA-binding site [nucleotide binding]; DNA binding site
1116391018963	UTRA domain; Region: UTRA; pfam07702
1116391018964	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1116391018965	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1116391018966	substrate binding site [chemical binding]; other site
1116391018967	ATP binding site [chemical binding]; other site
1116391018968	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1116391018969	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1116391018970	putative active site [active]
1116391018971	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1116391018972	fructoselysine 3-epimerase; Provisional; Region: PRK09856
1116391018973	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391018974	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
1116391018975	oligomer interface [polypeptide binding]; other site
1116391018976	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1116391018977	Protein of unknown function (DUF458); Region: DUF458; pfam04308
1116391018978	NAD-dependent deacetylase; Provisional; Region: PRK00481
1116391018979	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1116391018980	NAD+ binding site [chemical binding]; other site
1116391018981	substrate binding site [chemical binding]; other site
1116391018982	Zn binding site [ion binding]; other site
1116391018983	xylose isomerase; Provisional; Region: PRK05474
1116391018984	xylose isomerase; Region: xylose_isom_A; TIGR02630
1116391018985	DinB superfamily; Region: DinB_2; pfam12867
1116391018986	DinB family; Region: DinB; cl17821
1116391018987	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391018988	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1116391018989	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391018990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391018991	active site
1116391018992	phosphorylation site [posttranslational modification]
1116391018993	intermolecular recognition site; other site
1116391018994	dimerization interface [polypeptide binding]; other site
1116391018995	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391018996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018997	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391018998	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1116391018999	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391019000	dimerization interface [polypeptide binding]; other site
1116391019001	Histidine kinase; Region: His_kinase; pfam06580
1116391019002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019003	ATP binding site [chemical binding]; other site
1116391019004	Mg2+ binding site [ion binding]; other site
1116391019005	G-X-G motif; other site
1116391019006	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391019007	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019008	dimer interface [polypeptide binding]; other site
1116391019009	conserved gate region; other site
1116391019010	putative PBP binding loops; other site
1116391019011	ABC-ATPase subunit interface; other site
1116391019012	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391019013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019014	dimer interface [polypeptide binding]; other site
1116391019015	conserved gate region; other site
1116391019016	putative PBP binding loops; other site
1116391019017	ABC-ATPase subunit interface; other site
1116391019018	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391019019	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391019020	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391019021	active site
1116391019022	catalytic tetrad [active]
1116391019023	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1116391019024	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
1116391019025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019026	dimer interface [polypeptide binding]; other site
1116391019027	conserved gate region; other site
1116391019028	putative PBP binding loops; other site
1116391019029	ABC-ATPase subunit interface; other site
1116391019030	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391019031	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391019032	substrate binding pocket [chemical binding]; other site
1116391019033	membrane-bound complex binding site; other site
1116391019034	hinge residues; other site
1116391019035	Nuclease-related domain; Region: NERD; pfam08378
1116391019036	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391019037	ATP binding site [chemical binding]; other site
1116391019038	putative Mg++ binding site [ion binding]; other site
1116391019039	Family description; Region: UvrD_C_2; pfam13538
1116391019040	Protein of unknown function (DUF693); Region: DUF693; pfam05113
1116391019041	DNA-sulfur modification-associated; Region: DndB; pfam14072
1116391019042	DGQHR domain; Region: DGQHR; TIGR03187
1116391019043	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1116391019044	GIY-YIG motif/motif A; other site
1116391019045	active site
1116391019046	catalytic site [active]
1116391019047	metal binding site [ion binding]; metal-binding site
1116391019048	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1116391019049	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1116391019050	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1116391019051	Ligand Binding Site [chemical binding]; other site
1116391019052	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
1116391019053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391019054	Walker A motif; other site
1116391019055	ATP binding site [chemical binding]; other site
1116391019056	Walker B motif; other site
1116391019057	arginine finger; other site
1116391019058	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1116391019059	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1116391019060	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1116391019061	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
1116391019062	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1116391019063	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1116391019064	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1116391019065	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1116391019066	DNA interaction; other site
1116391019067	Metal-binding active site; metal-binding site
1116391019068	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1116391019069	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1116391019070	active site
1116391019071	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1116391019072	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1116391019073	putative metal binding site; other site
1116391019074	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1116391019075	active site
1116391019076	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
1116391019077	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
1116391019078	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1116391019079	TROVE domain; Region: TROVE; pfam05731
1116391019080	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1116391019081	metal ion-dependent adhesion site (MIDAS); other site
1116391019082	WYL domain; Region: WYL; pfam13280
1116391019083	WYL domain; Region: WYL; pfam13280
1116391019084	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1116391019085	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1116391019086	ring oligomerisation interface [polypeptide binding]; other site
1116391019087	ATP/Mg binding site [chemical binding]; other site
1116391019088	stacking interactions; other site
1116391019089	hinge regions; other site
1116391019090	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1116391019091	oligomerisation interface [polypeptide binding]; other site
1116391019092	mobile loop; other site
1116391019093	roof hairpin; other site
1116391019094	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1116391019095	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1116391019096	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391019097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019098	dimer interface [polypeptide binding]; other site
1116391019099	conserved gate region; other site
1116391019100	putative PBP binding loops; other site
1116391019101	ABC-ATPase subunit interface; other site
1116391019102	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1116391019103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019104	dimer interface [polypeptide binding]; other site
1116391019105	conserved gate region; other site
1116391019106	putative PBP binding loops; other site
1116391019107	ABC-ATPase subunit interface; other site
1116391019108	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1116391019109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391019110	Walker A/P-loop; other site
1116391019111	ATP binding site [chemical binding]; other site
1116391019112	Q-loop/lid; other site
1116391019113	ABC transporter signature motif; other site
1116391019114	Walker B; other site
1116391019115	D-loop; other site
1116391019116	H-loop/switch region; other site
1116391019117	TOBE domain; Region: TOBE_2; pfam08402
1116391019118	Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427
1116391019119	putative binding site; other site
1116391019120	putative dimer interface [polypeptide binding]; other site
1116391019121	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019122	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019123	active site
1116391019124	phosphorylation site [posttranslational modification]
1116391019125	intermolecular recognition site; other site
1116391019126	dimerization interface [polypeptide binding]; other site
1116391019127	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391019128	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019129	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391019130	dimerization interface [polypeptide binding]; other site
1116391019131	Histidine kinase; Region: His_kinase; pfam06580
1116391019132	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019133	ATP binding site [chemical binding]; other site
1116391019134	Mg2+ binding site [ion binding]; other site
1116391019135	G-X-G motif; other site
1116391019136	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391019137	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391019138	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391019139	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391019140	Walker A/P-loop; other site
1116391019141	ATP binding site [chemical binding]; other site
1116391019142	Q-loop/lid; other site
1116391019143	ABC transporter signature motif; other site
1116391019144	Walker B; other site
1116391019145	D-loop; other site
1116391019146	H-loop/switch region; other site
1116391019147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391019148	Transposase; Region: HTH_Tnp_1; cl17663
1116391019149	HTH-like domain; Region: HTH_21; pfam13276
1116391019150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391019151	Integrase core domain; Region: rve; pfam00665
1116391019152	Integrase core domain; Region: rve_3; pfam13683
1116391019153	LysE type translocator; Region: LysE; cl00565
1116391019154	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1116391019155	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1116391019156	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1116391019157	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1116391019158	active site
1116391019159	dimer interface [polypeptide binding]; other site
1116391019160	motif 1; other site
1116391019161	motif 2; other site
1116391019162	motif 3; other site
1116391019163	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1116391019164	anticodon binding site; other site
1116391019165	amidase; Provisional; Region: PRK06828
1116391019166	Amidase; Region: Amidase; cl11426
1116391019167	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1116391019168	S-layer homology domain; Region: SLH; pfam00395
1116391019169	TraX protein; Region: TraX; cl05434
1116391019170	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1116391019171	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1116391019172	Subunit I/III interface [polypeptide binding]; other site
1116391019173	Subunit III/IV interface [polypeptide binding]; other site
1116391019174	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1116391019175	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1116391019176	D-pathway; other site
1116391019177	Putative ubiquinol binding site [chemical binding]; other site
1116391019178	Low-spin heme (heme b) binding site [chemical binding]; other site
1116391019179	Putative water exit pathway; other site
1116391019180	Binuclear center (heme o3/CuB) [ion binding]; other site
1116391019181	K-pathway; other site
1116391019182	Putative proton exit pathway; other site
1116391019183	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1116391019184	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1116391019185	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1116391019186	Pectinesterase; Region: Pectinesterase; pfam01095
1116391019187	putative pectinesterase; Region: PLN02432; cl01911
1116391019188	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1116391019189	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1116391019190	catalytic residues [active]
1116391019191	dimer interface [polypeptide binding]; other site
1116391019192	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1116391019193	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
1116391019194	ligand binding site [chemical binding]; other site
1116391019195	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391019196	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391019197	TM-ABC transporter signature motif; other site
1116391019198	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391019199	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1116391019200	TM-ABC transporter signature motif; other site
1116391019201	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391019202	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391019203	Walker A/P-loop; other site
1116391019204	ATP binding site [chemical binding]; other site
1116391019205	Q-loop/lid; other site
1116391019206	ABC transporter signature motif; other site
1116391019207	Walker B; other site
1116391019208	D-loop; other site
1116391019209	H-loop/switch region; other site
1116391019210	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391019211	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1116391019212	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391019213	Walker A/P-loop; other site
1116391019214	ATP binding site [chemical binding]; other site
1116391019215	Q-loop/lid; other site
1116391019216	ABC transporter signature motif; other site
1116391019217	Walker B; other site
1116391019218	D-loop; other site
1116391019219	H-loop/switch region; other site
1116391019220	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391019221	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1116391019222	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1116391019223	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1116391019224	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391019225	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391019226	DNA binding residues [nucleotide binding]
1116391019227	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1116391019228	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1116391019229	DNA binding residues [nucleotide binding]
1116391019230	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
1116391019231	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1116391019232	Cache domain; Region: Cache_1; pfam02743
1116391019233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391019234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391019235	metal binding site [ion binding]; metal-binding site
1116391019236	active site
1116391019237	I-site; other site
1116391019238	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1116391019239	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391019240	putative metal binding site [ion binding]; other site
1116391019241	DoxX; Region: DoxX; pfam07681
1116391019242	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391019243	sequence-specific DNA binding site [nucleotide binding]; other site
1116391019244	salt bridge; other site
1116391019245	Cupin domain; Region: Cupin_2; pfam07883
1116391019246	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391019247	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019248	ATP binding site [chemical binding]; other site
1116391019249	Mg2+ binding site [ion binding]; other site
1116391019250	G-X-G motif; other site
1116391019251	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391019252	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
1116391019253	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391019254	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019255	dimer interface [polypeptide binding]; other site
1116391019256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019257	ATP binding site [chemical binding]; other site
1116391019258	Mg2+ binding site [ion binding]; other site
1116391019259	G-X-G motif; other site
1116391019260	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1116391019261	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1116391019262	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1116391019263	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1116391019264	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1116391019265	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1116391019266	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1116391019267	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1116391019268	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1116391019269	Walker A motif; other site
1116391019270	ATP binding site [chemical binding]; other site
1116391019271	Walker B motif; other site
1116391019272	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1116391019273	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1116391019274	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1116391019275	Walker A motif; other site
1116391019276	ATP binding site [chemical binding]; other site
1116391019277	Walker B motif; other site
1116391019278	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1116391019279	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1116391019280	Bacterial Ig-like domain 2; Region: BID_2; smart00635
1116391019281	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1116391019282	NAD-dependent deacetylase; Provisional; Region: PRK00481
1116391019283	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1116391019284	NAD+ binding site [chemical binding]; other site
1116391019285	substrate binding site [chemical binding]; other site
1116391019286	Zn binding site [ion binding]; other site
1116391019287	pullulanase, type I; Region: pulA_typeI; TIGR02104
1116391019288	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1116391019289	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1116391019290	Ca binding site [ion binding]; other site
1116391019291	active site
1116391019292	catalytic site [active]
1116391019293	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1116391019294	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1116391019295	tetramer interface [polypeptide binding]; other site
1116391019296	heme binding pocket [chemical binding]; other site
1116391019297	NADPH binding site [chemical binding]; other site
1116391019298	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391019299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019300	active site
1116391019301	phosphorylation site [posttranslational modification]
1116391019302	intermolecular recognition site; other site
1116391019303	dimerization interface [polypeptide binding]; other site
1116391019304	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391019305	DNA binding residues [nucleotide binding]
1116391019306	dimerization interface [polypeptide binding]; other site
1116391019307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391019308	TspO/MBR family; Region: TspO_MBR; cl01379
1116391019309	Histidine kinase; Region: HisKA_3; pfam07730
1116391019310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019311	ATP binding site [chemical binding]; other site
1116391019312	Mg2+ binding site [ion binding]; other site
1116391019313	G-X-G motif; other site
1116391019314	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1116391019315	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1116391019316	putative di-iron ligands [ion binding]; other site
1116391019317	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1116391019318	active site
1116391019319	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1116391019320	active site
1116391019321	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1116391019322	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1116391019323	putative sugar binding sites [chemical binding]; other site
1116391019324	Q-X-W motif; other site
1116391019325	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1116391019326	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1116391019327	putative ADP-binding pocket [chemical binding]; other site
1116391019328	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1116391019329	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1116391019330	HEAT repeats; Region: HEAT_2; pfam13646
1116391019331	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1116391019332	nudix motif; other site
1116391019333	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1116391019334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391019335	S-adenosylmethionine binding site [chemical binding]; other site
1116391019336	putative lipid kinase; Reviewed; Region: PRK13337
1116391019337	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1116391019338	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1116391019339	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1116391019340	putative active site [active]
1116391019341	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1116391019342	putative active site [active]
1116391019343	TrpR-related protein YerC/YecD; Region: yecD_yerC; TIGR02531
1116391019344	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1116391019345	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1116391019346	active site
1116391019347	FMN binding site [chemical binding]; other site
1116391019348	substrate binding site [chemical binding]; other site
1116391019349	homotetramer interface [polypeptide binding]; other site
1116391019350	catalytic residue [active]
1116391019351	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1116391019352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391019353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019354	dimer interface [polypeptide binding]; other site
1116391019355	phosphorylation site [posttranslational modification]
1116391019356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019357	ATP binding site [chemical binding]; other site
1116391019358	Mg2+ binding site [ion binding]; other site
1116391019359	G-X-G motif; other site
1116391019360	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1116391019361	Cupin domain; Region: Cupin_2; pfam07883
1116391019362	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391019363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019364	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391019365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019366	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391019367	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019368	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391019369	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019370	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391019371	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
1116391019372	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391019373	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391019374	DNA binding residues [nucleotide binding]
1116391019375	Predicted membrane protein [Function unknown]; Region: COG2261
1116391019376	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391019377	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391019378	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1116391019379	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391019380	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1116391019381	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391019382	DNA binding residues [nucleotide binding]
1116391019383	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1116391019384	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1116391019385	ATP binding site [chemical binding]; other site
1116391019386	G-X-G motif; other site
1116391019387	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1116391019388	anti sigma factor interaction site; other site
1116391019389	regulatory phosphorylation site [posttranslational modification]; other site
1116391019390	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1116391019391	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1116391019392	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1116391019393	dimerization interface [polypeptide binding]; other site
1116391019394	DPS ferroxidase diiron center [ion binding]; other site
1116391019395	ion pore; other site
1116391019396	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1116391019397	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1116391019398	ligand binding site [chemical binding]; other site
1116391019399	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1116391019400	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1116391019401	Walker A/P-loop; other site
1116391019402	ATP binding site [chemical binding]; other site
1116391019403	Q-loop/lid; other site
1116391019404	ABC transporter signature motif; other site
1116391019405	Walker B; other site
1116391019406	D-loop; other site
1116391019407	H-loop/switch region; other site
1116391019408	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1116391019409	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1116391019410	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391019411	TM-ABC transporter signature motif; other site
1116391019412	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1116391019413	TM-ABC transporter signature motif; other site
1116391019414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1116391019415	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1116391019416	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1116391019417	anti sigma factor interaction site; other site
1116391019418	regulatory phosphorylation site [posttranslational modification]; other site
1116391019419	Heat induced stress protein YflT; Region: YflT; pfam11181
1116391019420	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1116391019421	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1116391019422	ligand binding site; other site
1116391019423	oligomer interface; other site
1116391019424	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1116391019425	N-terminal domain interface [polypeptide binding]; other site
1116391019426	sulfate 1 binding site; other site
1116391019427	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391019428	Interdomain contacts; other site
1116391019429	Cytokine receptor motif; other site
1116391019430	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391019431	Interdomain contacts; other site
1116391019432	Cytokine receptor motif; other site
1116391019433	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391019434	dockerin binding interface; other site
1116391019435	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019437	active site
1116391019438	phosphorylation site [posttranslational modification]
1116391019439	intermolecular recognition site; other site
1116391019440	dimerization interface [polypeptide binding]; other site
1116391019441	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019442	dimer interface [polypeptide binding]; other site
1116391019443	phosphorylation site [posttranslational modification]
1116391019444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019445	ATP binding site [chemical binding]; other site
1116391019446	Mg2+ binding site [ion binding]; other site
1116391019447	G-X-G motif; other site
1116391019448	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1116391019449	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1116391019450	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1116391019451	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1116391019452	dimerization interface [polypeptide binding]; other site
1116391019453	GAF domain; Region: GAF_3; pfam13492
1116391019454	GAF domain; Region: GAF_2; pfam13185
1116391019455	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019456	dimer interface [polypeptide binding]; other site
1116391019457	phosphorylation site [posttranslational modification]
1116391019458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019459	ATP binding site [chemical binding]; other site
1116391019460	Mg2+ binding site [ion binding]; other site
1116391019461	G-X-G motif; other site
1116391019462	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019464	active site
1116391019465	phosphorylation site [posttranslational modification]
1116391019466	intermolecular recognition site; other site
1116391019467	dimerization interface [polypeptide binding]; other site
1116391019468	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019470	active site
1116391019471	phosphorylation site [posttranslational modification]
1116391019472	intermolecular recognition site; other site
1116391019473	dimerization interface [polypeptide binding]; other site
1116391019474	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019476	active site
1116391019477	phosphorylation site [posttranslational modification]
1116391019478	intermolecular recognition site; other site
1116391019479	dimerization interface [polypeptide binding]; other site
1116391019480	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391019481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019482	active site
1116391019483	phosphorylation site [posttranslational modification]
1116391019484	intermolecular recognition site; other site
1116391019485	dimerization interface [polypeptide binding]; other site
1116391019486	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1116391019487	Heat induced stress protein YflT; Region: YflT; pfam11181
1116391019488	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391019489	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1116391019490	NodB motif; other site
1116391019491	active site
1116391019492	catalytic site [active]
1116391019493	metal binding site [ion binding]; metal-binding site
1116391019494	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
1116391019495	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391019496	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391019497	DNA binding residues [nucleotide binding]
1116391019498	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
1116391019499	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1116391019500	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1116391019501	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1116391019502	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1116391019503	putative active site [active]
1116391019504	metal binding site [ion binding]; metal-binding site
1116391019505	DinB superfamily; Region: DinB_2; pfam12867
1116391019506	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391019507	HTH domain; Region: HTH_11; pfam08279
1116391019508	WYL domain; Region: WYL; pfam13280
1116391019509	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1116391019510	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1116391019511	catalytic residues [active]
1116391019512	IDEAL domain; Region: IDEAL; cl07452
1116391019513	Predicted transcriptional regulator [Transcription]; Region: COG1959
1116391019514	Transcriptional regulator; Region: Rrf2; pfam02082
1116391019515	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1116391019516	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1116391019517	siderophore binding site; other site
1116391019518	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1116391019519	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391019520	ABC-ATPase subunit  interface; other site
1116391019521	dimer interface [polypeptide binding]; other site
1116391019522	putative PBP binding regions; other site
1116391019523	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1116391019524	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391019525	ABC-ATPase subunit  interface; other site
1116391019526	dimer interface [polypeptide binding]; other site
1116391019527	putative PBP binding regions; other site
1116391019528	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1116391019529	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1116391019530	Walker A/P-loop; other site
1116391019531	ATP binding site [chemical binding]; other site
1116391019532	Q-loop/lid; other site
1116391019533	ABC transporter signature motif; other site
1116391019534	Walker B; other site
1116391019535	D-loop; other site
1116391019536	H-loop/switch region; other site
1116391019537	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1116391019538	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1116391019539	active site
1116391019540	TDP-binding site; other site
1116391019541	acceptor substrate-binding pocket; other site
1116391019542	homodimer interface [polypeptide binding]; other site
1116391019543	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1116391019544	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1116391019545	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1116391019546	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1116391019547	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
1116391019548	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
1116391019549	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1116391019550	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1116391019551	active site
1116391019552	substrate binding site [chemical binding]; other site
1116391019553	cosubstrate binding site; other site
1116391019554	catalytic site [active]
1116391019555	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1116391019556	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1116391019557	dimerization interface [polypeptide binding]; other site
1116391019558	putative ATP binding site [chemical binding]; other site
1116391019559	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
1116391019560	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1116391019561	active site
1116391019562	tetramer interface [polypeptide binding]; other site
1116391019563	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391019564	active site
1116391019565	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1116391019566	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1116391019567	dimerization interface [polypeptide binding]; other site
1116391019568	ATP binding site [chemical binding]; other site
1116391019569	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1116391019570	dimerization interface [polypeptide binding]; other site
1116391019571	ATP binding site [chemical binding]; other site
1116391019572	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1116391019573	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1116391019574	putative active site [active]
1116391019575	catalytic triad [active]
1116391019576	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1116391019577	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1116391019578	ATP binding site [chemical binding]; other site
1116391019579	active site
1116391019580	substrate binding site [chemical binding]; other site
1116391019581	adenylosuccinate lyase; Provisional; Region: PRK07492
1116391019582	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1116391019583	tetramer interface [polypeptide binding]; other site
1116391019584	active site
1116391019585	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1116391019586	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391019587	3D domain; Region: 3D; cl01439
1116391019588	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391019589	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1116391019590	NodB motif; other site
1116391019591	active site
1116391019592	catalytic site [active]
1116391019593	metal binding site [ion binding]; metal-binding site
1116391019594	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1116391019595	UGMP family protein; Validated; Region: PRK09604
1116391019596	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1116391019597	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1116391019598	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391019599	Coenzyme A binding pocket [chemical binding]; other site
1116391019600	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1116391019601	Glycoprotease family; Region: Peptidase_M22; pfam00814
1116391019602	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1116391019603	thiamine monophosphate kinase; Provisional; Region: PRK05731
1116391019604	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1116391019605	ATP binding site [chemical binding]; other site
1116391019606	dimerization interface [polypeptide binding]; other site
1116391019607	Small acid-soluble spore protein H family; Region: SspH; cl06949
1116391019608	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1116391019609	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1116391019610	putative DNA binding site [nucleotide binding]; other site
1116391019611	putative homodimer interface [polypeptide binding]; other site
1116391019612	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
1116391019613	TrkA-C domain; Region: TrkA_C; pfam02080
1116391019614	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1116391019615	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1116391019616	active site
1116391019617	DNA binding site [nucleotide binding]
1116391019618	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1116391019619	DNA binding site [nucleotide binding]
1116391019620	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1116391019621	nucleotide binding site [chemical binding]; other site
1116391019622	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1116391019623	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1116391019624	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1116391019625	putative active site [active]
1116391019626	catalytic site [active]
1116391019627	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1116391019628	putative active site [active]
1116391019629	catalytic site [active]
1116391019630	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1116391019631	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1116391019632	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1116391019633	Spore germination protein; Region: Spore_permease; cl17796
1116391019634	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
1116391019635	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391019636	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391019637	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1116391019638	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1116391019639	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1116391019640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391019641	motif II; other site
1116391019642	aminoglycoside resistance protein; Provisional; Region: PRK13746
1116391019643	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1116391019644	metal binding triad [ion binding]; metal-binding site
1116391019645	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1116391019646	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
1116391019647	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1116391019648	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1116391019649	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1116391019650	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1116391019651	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391019652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391019653	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1116391019654	putative active site [active]
1116391019655	heme pocket [chemical binding]; other site
1116391019656	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391019657	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1116391019658	putative active site [active]
1116391019659	heme pocket [chemical binding]; other site
1116391019660	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391019661	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1116391019662	putative active site [active]
1116391019663	heme pocket [chemical binding]; other site
1116391019664	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019665	phosphorylation site [posttranslational modification]
1116391019666	dimer interface [polypeptide binding]; other site
1116391019667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019668	ATP binding site [chemical binding]; other site
1116391019669	Mg2+ binding site [ion binding]; other site
1116391019670	G-X-G motif; other site
1116391019671	thymidine kinase; Provisional; Region: PRK04296
1116391019672	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1116391019673	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391019674	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391019675	homodimer interface [polypeptide binding]; other site
1116391019676	catalytic residue [active]
1116391019677	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1116391019678	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1116391019679	DNA-binding site [nucleotide binding]; DNA binding site
1116391019680	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1116391019681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391019682	homodimer interface [polypeptide binding]; other site
1116391019683	catalytic residue [active]
1116391019684	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1116391019685	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391019686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1116391019687	DNA binding residues [nucleotide binding]
1116391019688	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1116391019689	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1116391019690	putative active site [active]
1116391019691	putative metal binding site [ion binding]; other site
1116391019692	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1116391019693	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391019694	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
1116391019695	putative homodimer interface [polypeptide binding]; other site
1116391019696	putative homotetramer interface [polypeptide binding]; other site
1116391019697	allosteric switch controlling residues; other site
1116391019698	putative metal binding site [ion binding]; other site
1116391019699	putative homodimer-homodimer interface [polypeptide binding]; other site
1116391019700	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1116391019701	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391019702	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1116391019703	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1116391019704	proposed catalytic triad [active]
1116391019705	conserved cys residue [active]
1116391019706	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1116391019707	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1116391019708	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391019709	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019710	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1116391019711	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1116391019712	putative ADP-ribose binding site [chemical binding]; other site
1116391019713	putative active site [active]
1116391019714	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019716	active site
1116391019717	phosphorylation site [posttranslational modification]
1116391019718	intermolecular recognition site; other site
1116391019719	dimerization interface [polypeptide binding]; other site
1116391019720	Coat F domain; Region: Coat_F; pfam07875
1116391019721	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391019722	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391019723	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1116391019724	CheW-like domain; Region: CheW; pfam01584
1116391019725	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1116391019726	lipoyl attachment site [posttranslational modification]; other site
1116391019727	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1116391019728	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1116391019729	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1116391019730	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1116391019731	tetramer interface [polypeptide binding]; other site
1116391019732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391019733	catalytic residue [active]
1116391019734	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1116391019735	tetramer interface [polypeptide binding]; other site
1116391019736	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391019737	catalytic residue [active]
1116391019738	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
1116391019739	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
1116391019740	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
1116391019741	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1116391019742	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
1116391019743	Lamin Tail Domain; Region: LTD; pfam00932
1116391019744	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1116391019745	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391019746	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391019747	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019748	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1116391019749	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1116391019750	DNA binding site [nucleotide binding]
1116391019751	domain linker motif; other site
1116391019752	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1116391019753	putative dimerization interface [polypeptide binding]; other site
1116391019754	putative ligand binding site [chemical binding]; other site
1116391019755	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391019756	Interdomain contacts; other site
1116391019757	Cytokine receptor motif; other site
1116391019758	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391019759	Interdomain contacts; other site
1116391019760	Cytokine receptor motif; other site
1116391019761	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1116391019762	dockerin binding interface; other site
1116391019763	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1116391019764	Glyco_18 domain; Region: Glyco_18; smart00636
1116391019765	active site
1116391019766	S-layer homology domain; Region: SLH; pfam00395
1116391019767	S-layer homology domain; Region: SLH; pfam00395
1116391019768	S-layer homology domain; Region: SLH; pfam00395
1116391019769	phytoene desaturase; Region: phytoene_desat; TIGR02731
1116391019770	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1116391019771	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1116391019772	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1116391019773	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1116391019774	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1116391019775	oligomer interface [polypeptide binding]; other site
1116391019776	metal binding site [ion binding]; metal-binding site
1116391019777	metal binding site [ion binding]; metal-binding site
1116391019778	putative Cl binding site [ion binding]; other site
1116391019779	aspartate ring; other site
1116391019780	basic sphincter; other site
1116391019781	hydrophobic gate; other site
1116391019782	periplasmic entrance; other site
1116391019783	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1116391019784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1116391019785	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391019786	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391019787	Predicted membrane protein [Function unknown]; Region: COG3326
1116391019788	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1116391019789	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391019790	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391019791	metal binding site [ion binding]; metal-binding site
1116391019792	active site
1116391019793	I-site; other site
1116391019794	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019795	dimer interface [polypeptide binding]; other site
1116391019796	phosphorylation site [posttranslational modification]
1116391019797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019798	ATP binding site [chemical binding]; other site
1116391019799	Mg2+ binding site [ion binding]; other site
1116391019800	G-X-G motif; other site
1116391019801	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391019802	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019803	active site
1116391019804	phosphorylation site [posttranslational modification]
1116391019805	intermolecular recognition site; other site
1116391019806	dimerization interface [polypeptide binding]; other site
1116391019807	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391019808	DNA binding site [nucleotide binding]
1116391019809	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1116391019810	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391019811	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391019812	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391019813	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391019814	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1116391019815	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391019816	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019817	dimer interface [polypeptide binding]; other site
1116391019818	conserved gate region; other site
1116391019819	putative PBP binding loops; other site
1116391019820	ABC-ATPase subunit interface; other site
1116391019821	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391019822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391019823	dimer interface [polypeptide binding]; other site
1116391019824	conserved gate region; other site
1116391019825	ABC-ATPase subunit interface; other site
1116391019826	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1116391019827	active site
1116391019828	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1116391019829	sugar binding site [chemical binding]; other site
1116391019830	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1116391019831	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
1116391019832	NAD(P) binding site [chemical binding]; other site
1116391019833	catalytic residues [active]
1116391019834	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
1116391019835	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391019836	inhibitor-cofactor binding pocket; inhibition site
1116391019837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391019838	catalytic residue [active]
1116391019839	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
1116391019840	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1116391019841	inhibitor-cofactor binding pocket; inhibition site
1116391019842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391019843	catalytic residue [active]
1116391019844	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1116391019845	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1116391019846	tetramerization interface [polypeptide binding]; other site
1116391019847	NAD(P) binding site [chemical binding]; other site
1116391019848	catalytic residues [active]
1116391019849	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1116391019850	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1116391019851	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1116391019852	NAD(P) binding site [chemical binding]; other site
1116391019853	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1116391019854	tetramer interface [polypeptide binding]; other site
1116391019855	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1116391019856	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1116391019857	active site
1116391019858	multimer interface [polypeptide binding]; other site
1116391019859	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1116391019860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391019861	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019862	ATP binding site [chemical binding]; other site
1116391019863	Mg2+ binding site [ion binding]; other site
1116391019864	G-X-G motif; other site
1116391019865	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391019866	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019867	active site
1116391019868	phosphorylation site [posttranslational modification]
1116391019869	intermolecular recognition site; other site
1116391019870	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1116391019871	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1116391019872	carboxyltransferase (CT) interaction site; other site
1116391019873	biotinylation site [posttranslational modification]; other site
1116391019874	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1116391019875	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1116391019876	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391019877	putative active site [active]
1116391019878	heme pocket [chemical binding]; other site
1116391019879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391019880	Walker A motif; other site
1116391019881	ATP binding site [chemical binding]; other site
1116391019882	Walker B motif; other site
1116391019883	arginine finger; other site
1116391019884	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1116391019885	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1116391019886	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1116391019887	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1116391019888	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1116391019889	agmatinase; Region: agmatinase; TIGR01230
1116391019890	oligomer interface [polypeptide binding]; other site
1116391019891	putative active site [active]
1116391019892	Mn binding site [ion binding]; other site
1116391019893	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1116391019894	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1116391019895	HIGH motif; other site
1116391019896	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1116391019897	active site
1116391019898	KMSKS motif; other site
1116391019899	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1116391019900	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019901	ATP binding site [chemical binding]; other site
1116391019902	Mg2+ binding site [ion binding]; other site
1116391019903	G-X-G motif; other site
1116391019904	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1116391019905	Amidinotransferase; Region: Amidinotransf; pfam02274
1116391019906	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1116391019907	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1116391019908	active site
1116391019909	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1116391019910	Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300
1116391019911	catalytic core [active]
1116391019912	EamA-like transporter family; Region: EamA; pfam00892
1116391019913	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1116391019914	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1116391019915	glutaminase active site [active]
1116391019916	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1116391019917	dimer interface [polypeptide binding]; other site
1116391019918	active site
1116391019919	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1116391019920	dimer interface [polypeptide binding]; other site
1116391019921	active site
1116391019922	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1116391019923	YbbR-like protein; Region: YbbR; pfam07949
1116391019924	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1116391019925	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1116391019926	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1116391019927	Putative zinc-finger; Region: zf-HC2; pfam13490
1116391019928	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1116391019929	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1116391019930	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
1116391019931	CHASE3 domain; Region: CHASE3; pfam05227
1116391019932	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391019933	dimerization interface [polypeptide binding]; other site
1116391019934	GAF domain; Region: GAF_2; pfam13185
1116391019935	GAF domain; Region: GAF; pfam01590
1116391019936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391019937	dimer interface [polypeptide binding]; other site
1116391019938	phosphorylation site [posttranslational modification]
1116391019939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391019940	ATP binding site [chemical binding]; other site
1116391019941	Mg2+ binding site [ion binding]; other site
1116391019942	G-X-G motif; other site
1116391019943	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391019944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391019945	active site
1116391019946	phosphorylation site [posttranslational modification]
1116391019947	intermolecular recognition site; other site
1116391019948	dimerization interface [polypeptide binding]; other site
1116391019949	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1116391019950	homodimer interface [polypeptide binding]; other site
1116391019951	maltodextrin glucosidase; Provisional; Region: PRK10785
1116391019952	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1116391019953	active site
1116391019954	homodimer interface [polypeptide binding]; other site
1116391019955	catalytic site [active]
1116391019956	Heat induced stress protein YflT; Region: YflT; pfam11181
1116391019957	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1116391019958	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1116391019959	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1116391019960	classical (c) SDRs; Region: SDR_c; cd05233
1116391019961	NAD(P) binding site [chemical binding]; other site
1116391019962	active site
1116391019963	Integral membrane protein DUF95; Region: DUF95; pfam01944
1116391019964	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1116391019965	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1116391019966	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
1116391019967	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
1116391019968	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1116391019969	Walker A motif; other site
1116391019970	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1116391019971	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1116391019972	active site
1116391019973	metal binding site [ion binding]; metal-binding site
1116391019974	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1116391019975	ATP-sulfurylase; Region: ATPS; cd00517
1116391019976	active site
1116391019977	HXXH motif; other site
1116391019978	flexible loop; other site
1116391019979	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1116391019980	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1116391019981	Active Sites [active]
1116391019982	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1116391019983	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1116391019984	23S rRNA interface [nucleotide binding]; other site
1116391019985	L3 interface [polypeptide binding]; other site
1116391019986	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1116391019987	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1116391019988	dimerization interface 3.5A [polypeptide binding]; other site
1116391019989	active site
1116391019990	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1116391019991	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1116391019992	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1116391019993	alphaNTD - beta interaction site [polypeptide binding]; other site
1116391019994	alphaNTD homodimer interface [polypeptide binding]; other site
1116391019995	alphaNTD - beta' interaction site [polypeptide binding]; other site
1116391019996	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1116391019997	30S ribosomal protein S11; Validated; Region: PRK05309
1116391019998	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1116391019999	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1116391020000	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1116391020001	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1116391020002	rRNA binding site [nucleotide binding]; other site
1116391020003	predicted 30S ribosome binding site; other site
1116391020004	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
1116391020005	RNA binding site [nucleotide binding]; other site
1116391020006	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1116391020007	active site
1116391020008	adenylate kinase; Reviewed; Region: adk; PRK00279
1116391020009	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1116391020010	AMP-binding site [chemical binding]; other site
1116391020011	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1116391020012	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1116391020013	SecY translocase; Region: SecY; pfam00344
1116391020014	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1116391020015	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1116391020016	23S rRNA binding site [nucleotide binding]; other site
1116391020017	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1116391020018	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1116391020019	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1116391020020	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1116391020021	5S rRNA interface [nucleotide binding]; other site
1116391020022	L27 interface [polypeptide binding]; other site
1116391020023	23S rRNA interface [nucleotide binding]; other site
1116391020024	L5 interface [polypeptide binding]; other site
1116391020025	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1116391020026	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1116391020027	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1116391020028	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1116391020029	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1116391020030	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1116391020031	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1116391020032	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1116391020033	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1116391020034	RNA binding site [nucleotide binding]; other site
1116391020035	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1116391020036	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1116391020037	23S rRNA interface [nucleotide binding]; other site
1116391020038	putative translocon interaction site; other site
1116391020039	signal recognition particle (SRP54) interaction site; other site
1116391020040	L23 interface [polypeptide binding]; other site
1116391020041	trigger factor interaction site; other site
1116391020042	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1116391020043	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1116391020044	G-X-X-G motif; other site
1116391020045	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1116391020046	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1116391020047	putative translocon binding site; other site
1116391020048	protein-rRNA interface [nucleotide binding]; other site
1116391020049	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1116391020050	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1116391020051	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1116391020052	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1116391020053	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1116391020054	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1116391020055	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1116391020056	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1116391020057	elongation factor Tu; Reviewed; Region: PRK00049
1116391020058	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1116391020059	G1 box; other site
1116391020060	GEF interaction site [polypeptide binding]; other site
1116391020061	GTP/Mg2+ binding site [chemical binding]; other site
1116391020062	Switch I region; other site
1116391020063	G2 box; other site
1116391020064	G3 box; other site
1116391020065	Switch II region; other site
1116391020066	G4 box; other site
1116391020067	G5 box; other site
1116391020068	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1116391020069	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1116391020070	Antibiotic Binding Site [chemical binding]; other site
1116391020071	30S ribosomal protein S7; Validated; Region: PRK05302
1116391020072	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1116391020073	S17 interaction site [polypeptide binding]; other site
1116391020074	S8 interaction site; other site
1116391020075	16S rRNA interaction site [nucleotide binding]; other site
1116391020076	streptomycin interaction site [chemical binding]; other site
1116391020077	23S rRNA interaction site [nucleotide binding]; other site
1116391020078	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1116391020079	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
1116391020080	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1116391020081	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1116391020082	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1116391020083	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1116391020084	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1116391020085	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1116391020086	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1116391020087	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1116391020088	G-loop; other site
1116391020089	DNA binding site [nucleotide binding]
1116391020090	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
1116391020091	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1116391020092	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1116391020093	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1116391020094	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1116391020095	RPB10 interaction site [polypeptide binding]; other site
1116391020096	RPB1 interaction site [polypeptide binding]; other site
1116391020097	RPB11 interaction site [polypeptide binding]; other site
1116391020098	RPB3 interaction site [polypeptide binding]; other site
1116391020099	RPB12 interaction site [polypeptide binding]; other site
1116391020100	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391020101	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391020102	S-adenosylmethionine binding site [chemical binding]; other site
1116391020103	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1116391020104	core dimer interface [polypeptide binding]; other site
1116391020105	peripheral dimer interface [polypeptide binding]; other site
1116391020106	L10 interface [polypeptide binding]; other site
1116391020107	L11 interface [polypeptide binding]; other site
1116391020108	putative EF-Tu interaction site [polypeptide binding]; other site
1116391020109	putative EF-G interaction site [polypeptide binding]; other site
1116391020110	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1116391020111	23S rRNA interface [nucleotide binding]; other site
1116391020112	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1116391020113	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1116391020114	mRNA/rRNA interface [nucleotide binding]; other site
1116391020115	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1116391020116	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1116391020117	23S rRNA interface [nucleotide binding]; other site
1116391020118	L7/L12 interface [polypeptide binding]; other site
1116391020119	putative thiostrepton binding site; other site
1116391020120	L25 interface [polypeptide binding]; other site
1116391020121	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1116391020122	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1116391020123	putative homodimer interface [polypeptide binding]; other site
1116391020124	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1116391020125	heterodimer interface [polypeptide binding]; other site
1116391020126	homodimer interface [polypeptide binding]; other site
1116391020127	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1116391020128	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1116391020129	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1116391020130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1116391020131	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1116391020132	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1116391020133	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1116391020134	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1116391020135	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1116391020136	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1116391020137	active site
1116391020138	dimerization interface [polypeptide binding]; other site
1116391020139	metal binding site [ion binding]; metal-binding site
1116391020140	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1116391020141	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1116391020142	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1116391020143	trimer interface [polypeptide binding]; other site
1116391020144	active site
1116391020145	substrate binding site [chemical binding]; other site
1116391020146	CoA binding site [chemical binding]; other site
1116391020147	Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565
1116391020148	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1116391020149	homotrimer interaction site [polypeptide binding]; other site
1116391020150	zinc binding site [ion binding]; other site
1116391020151	CDP-binding sites; other site
1116391020152	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1116391020153	substrate binding site; other site
1116391020154	dimer interface; other site
1116391020155	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1116391020156	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1116391020157	putative active site [active]
1116391020158	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1116391020159	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1116391020160	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1116391020161	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1116391020162	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1116391020163	DNA repair protein RadA; Provisional; Region: PRK11823
1116391020164	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1116391020165	Walker A motif/ATP binding site; other site
1116391020166	ATP binding site [chemical binding]; other site
1116391020167	Walker B motif; other site
1116391020168	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1116391020169	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1116391020170	Clp amino terminal domain; Region: Clp_N; pfam02861
1116391020171	Clp amino terminal domain; Region: Clp_N; pfam02861
1116391020172	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391020173	Walker A motif; other site
1116391020174	ATP binding site [chemical binding]; other site
1116391020175	Walker B motif; other site
1116391020176	arginine finger; other site
1116391020177	UvrB/uvrC motif; Region: UVR; pfam02151
1116391020178	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391020179	Walker A motif; other site
1116391020180	ATP binding site [chemical binding]; other site
1116391020181	Walker B motif; other site
1116391020182	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1116391020183	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1116391020184	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1116391020185	ADP binding site [chemical binding]; other site
1116391020186	phosphagen binding site; other site
1116391020187	substrate specificity loop; other site
1116391020188	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1116391020189	UvrB/uvrC motif; Region: UVR; pfam02151
1116391020190	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1116391020191	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1116391020192	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1116391020193	dimer interface [polypeptide binding]; other site
1116391020194	putative anticodon binding site; other site
1116391020195	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1116391020196	motif 1; other site
1116391020197	active site
1116391020198	motif 2; other site
1116391020199	motif 3; other site
1116391020200	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1116391020201	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1116391020202	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1116391020203	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1116391020204	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1116391020205	FMN binding site [chemical binding]; other site
1116391020206	active site
1116391020207	catalytic residues [active]
1116391020208	substrate binding site [chemical binding]; other site
1116391020209	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391020210	non-specific DNA binding site [nucleotide binding]; other site
1116391020211	salt bridge; other site
1116391020212	sequence-specific DNA binding site [nucleotide binding]; other site
1116391020213	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1116391020214	catalytic center binding site [active]
1116391020215	ATP binding site [chemical binding]; other site
1116391020216	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1116391020217	homooctamer interface [polypeptide binding]; other site
1116391020218	active site
1116391020219	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1116391020220	dihydropteroate synthase; Region: DHPS; TIGR01496
1116391020221	substrate binding pocket [chemical binding]; other site
1116391020222	dimer interface [polypeptide binding]; other site
1116391020223	inhibitor binding site; inhibition site
1116391020224	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1116391020225	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
1116391020226	homodimer interface [polypeptide binding]; other site
1116391020227	substrate-cofactor binding pocket; other site
1116391020228	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391020229	catalytic residue [active]
1116391020230	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1116391020231	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1116391020232	glutamine binding [chemical binding]; other site
1116391020233	catalytic triad [active]
1116391020234	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1116391020235	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1116391020236	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1116391020237	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1116391020238	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1116391020239	dimer interface [polypeptide binding]; other site
1116391020240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1116391020241	catalytic residue [active]
1116391020242	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1116391020243	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1116391020244	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1116391020245	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1116391020246	dimerization interface [polypeptide binding]; other site
1116391020247	domain crossover interface; other site
1116391020248	redox-dependent activation switch; other site
1116391020249	pantothenate kinase; Reviewed; Region: PRK13318
1116391020250	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1116391020251	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1116391020252	dimerization interface [polypeptide binding]; other site
1116391020253	active site
1116391020254	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
1116391020255	L-aspartate oxidase; Provisional; Region: PRK06175
1116391020256	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1116391020257	Quinolinate synthetase A protein; Region: NadA; pfam02445
1116391020258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391020259	active site
1116391020260	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1116391020261	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1116391020262	Ligand Binding Site [chemical binding]; other site
1116391020263	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1116391020264	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1116391020265	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1116391020266	active site
1116391020267	ATP binding site [chemical binding]; other site
1116391020268	substrate binding site [chemical binding]; other site
1116391020269	activation loop (A-loop); other site
1116391020270	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1116391020271	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1116391020272	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1116391020273	RNA binding site [nucleotide binding]; other site
1116391020274	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1116391020275	Septum formation initiator; Region: DivIC; pfam04977
1116391020276	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
1116391020277	YabP family; Region: YabP; cl06766
1116391020278	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391020279	RNA binding surface [nucleotide binding]; other site
1116391020280	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1116391020281	IHF dimer interface [polypeptide binding]; other site
1116391020282	IHF - DNA interface [nucleotide binding]; other site
1116391020283	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1116391020284	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1116391020285	putative SAM binding site [chemical binding]; other site
1116391020286	putative homodimer interface [polypeptide binding]; other site
1116391020287	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1116391020288	homodimer interface [polypeptide binding]; other site
1116391020289	metal binding site [ion binding]; metal-binding site
1116391020290	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1116391020291	homodimer interface [polypeptide binding]; other site
1116391020292	active site
1116391020293	putative chemical substrate binding site [chemical binding]; other site
1116391020294	metal binding site [ion binding]; metal-binding site
1116391020295	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1116391020296	stage V sporulation protein T; Region: spore_V_T; TIGR02851
1116391020297	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
1116391020298	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1116391020299	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1116391020300	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1116391020301	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1116391020302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391020303	ATP binding site [chemical binding]; other site
1116391020304	putative Mg++ binding site [ion binding]; other site
1116391020305	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391020306	nucleotide binding region [chemical binding]; other site
1116391020307	ATP-binding site [chemical binding]; other site
1116391020308	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1116391020309	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
1116391020310	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1116391020311	putative active site [active]
1116391020312	catalytic residue [active]
1116391020313	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1116391020314	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1116391020315	5S rRNA interface [nucleotide binding]; other site
1116391020316	CTC domain interface [polypeptide binding]; other site
1116391020317	L16 interface [polypeptide binding]; other site
1116391020318	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1116391020319	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1116391020320	Substrate binding site; other site
1116391020321	Mg++ binding site; other site
1116391020322	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1116391020323	active site
1116391020324	substrate binding site [chemical binding]; other site
1116391020325	CoA binding site [chemical binding]; other site
1116391020326	SpoVG; Region: SpoVG; cl00915
1116391020327	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1116391020328	homotrimer interaction site [polypeptide binding]; other site
1116391020329	putative active site [active]
1116391020330	pur operon repressor; Provisional; Region: PRK09213
1116391020331	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1116391020332	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391020333	active site
1116391020334	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1116391020335	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1116391020336	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1116391020337	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1116391020338	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1116391020339	YabG peptidase U57; Region: Peptidase_U57; cl05250
1116391020340	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1116391020341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391020342	S-adenosylmethionine binding site [chemical binding]; other site
1116391020343	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1116391020344	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1116391020345	putative active site [active]
1116391020346	putative metal binding site [ion binding]; other site
1116391020347	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1116391020348	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1116391020349	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1116391020350	G5 domain; Region: G5; pfam07501
1116391020351	3D domain; Region: 3D; cl01439
1116391020352	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1116391020353	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1116391020354	active site
1116391020355	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1116391020356	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1116391020357	Zn2+ binding site [ion binding]; other site
1116391020358	Mg2+ binding site [ion binding]; other site
1116391020359	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1116391020360	Predicted methyltransferases [General function prediction only]; Region: COG0313
1116391020361	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1116391020362	putative SAM binding site [chemical binding]; other site
1116391020363	putative homodimer interface [polypeptide binding]; other site
1116391020364	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1116391020365	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391020366	S-adenosylmethionine binding site [chemical binding]; other site
1116391020367	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1116391020368	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1116391020369	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1116391020370	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1116391020371	Protein of unknown function (DUF327); Region: DUF327; pfam03885
1116391020372	Protein of unknown function (DUF970); Region: DUF970; pfam06153
1116391020373	thymidylate kinase; Validated; Region: tmk; PRK00698
1116391020374	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1116391020375	TMP-binding site; other site
1116391020376	ATP-binding site [chemical binding]; other site
1116391020377	Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276
1116391020378	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1116391020379	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391020380	catalytic residue [active]
1116391020381	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
1116391020382	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
1116391020383	recombination protein RecR; Reviewed; Region: recR; PRK00076
1116391020384	RecR protein; Region: RecR; pfam02132
1116391020385	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1116391020386	putative active site [active]
1116391020387	putative metal-binding site [ion binding]; other site
1116391020388	tetramer interface [polypeptide binding]; other site
1116391020389	hypothetical protein; Validated; Region: PRK00153
1116391020390	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1116391020391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391020392	Walker A motif; other site
1116391020393	ATP binding site [chemical binding]; other site
1116391020394	Walker B motif; other site
1116391020395	arginine finger; other site
1116391020396	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1116391020397	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1116391020398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1116391020399	putative active site [active]
1116391020400	heme pocket [chemical binding]; other site
1116391020401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391020402	dimer interface [polypeptide binding]; other site
1116391020403	phosphorylation site [posttranslational modification]
1116391020404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391020405	ATP binding site [chemical binding]; other site
1116391020406	Mg2+ binding site [ion binding]; other site
1116391020407	G-X-G motif; other site
1116391020408	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1116391020409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391020410	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1116391020411	FeS/SAM binding site; other site
1116391020412	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1116391020413	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1116391020414	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1116391020415	RNA binding site [nucleotide binding]; other site
1116391020416	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1116391020417	multimer interface [polypeptide binding]; other site
1116391020418	Walker A motif; other site
1116391020419	ATP binding site [chemical binding]; other site
1116391020420	Walker B motif; other site
1116391020421	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1116391020422	hinge; other site
1116391020423	active site
1116391020424	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1116391020425	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1116391020426	intersubunit interface [polypeptide binding]; other site
1116391020427	active site
1116391020428	zinc binding site [ion binding]; other site
1116391020429	Na+ binding site [ion binding]; other site
1116391020430	Response regulator receiver domain; Region: Response_reg; pfam00072
1116391020431	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391020432	active site
1116391020433	phosphorylation site [posttranslational modification]
1116391020434	intermolecular recognition site; other site
1116391020435	dimerization interface [polypeptide binding]; other site
1116391020436	CTP synthetase; Validated; Region: pyrG; PRK05380
1116391020437	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1116391020438	Catalytic site [active]
1116391020439	active site
1116391020440	UTP binding site [chemical binding]; other site
1116391020441	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1116391020442	active site
1116391020443	putative oxyanion hole; other site
1116391020444	catalytic triad [active]
1116391020445	DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363
1116391020446	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1116391020447	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1116391020448	active site
1116391020449	catalytic residues [active]
1116391020450	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1116391020451	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391020452	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1116391020453	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391020454	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1116391020455	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1116391020456	putative active site [active]
1116391020457	putative metal binding site [ion binding]; other site
1116391020458	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
1116391020459	agmatinase; Region: agmatinase; TIGR01230
1116391020460	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1116391020461	putative active site [active]
1116391020462	Mn binding site [ion binding]; other site
1116391020463	spermidine synthase; Provisional; Region: PRK00811
1116391020464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391020465	Transglycosylase; Region: Transgly; pfam00912
1116391020466	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1116391020467	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391020468	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1116391020469	PBP superfamily domain; Region: PBP_like_2; cl17296
1116391020470	YwhD family; Region: YwhD; pfam08741
1116391020471	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
1116391020472	Zn binding site [ion binding]; other site
1116391020473	NlpC/P60 family; Region: NLPC_P60; pfam00877
1116391020474	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1116391020475	DNA photolyase; Region: DNA_photolyase; pfam00875
1116391020476	PspC domain; Region: PspC; pfam04024
1116391020477	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1116391020478	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1116391020479	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1116391020480	active site residue [active]
1116391020481	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1116391020482	active site residue [active]
1116391020483	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1116391020484	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1116391020485	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
1116391020486	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391020487	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391020488	dimer interface [polypeptide binding]; other site
1116391020489	putative CheW interface [polypeptide binding]; other site
1116391020490	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1116391020491	aromatic arch; other site
1116391020492	DCoH dimer interaction site [polypeptide binding]; other site
1116391020493	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1116391020494	DCoH tetramer interaction site [polypeptide binding]; other site
1116391020495	substrate binding site [chemical binding]; other site
1116391020496	SNF2 Helicase protein; Region: DUF3670; pfam12419
1116391020497	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1116391020498	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1116391020499	ATP binding site [chemical binding]; other site
1116391020500	putative Mg++ binding site [ion binding]; other site
1116391020501	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391020502	nucleotide binding region [chemical binding]; other site
1116391020503	ATP-binding site [chemical binding]; other site
1116391020504	CHASE3 domain; Region: CHASE3; pfam05227
1116391020505	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1116391020506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391020507	dimer interface [polypeptide binding]; other site
1116391020508	phosphorylation site [posttranslational modification]
1116391020509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391020510	ATP binding site [chemical binding]; other site
1116391020511	Mg2+ binding site [ion binding]; other site
1116391020512	G-X-G motif; other site
1116391020513	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1116391020514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391020515	active site
1116391020516	phosphorylation site [posttranslational modification]
1116391020517	intermolecular recognition site; other site
1116391020518	dimerization interface [polypeptide binding]; other site
1116391020519	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1116391020520	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1116391020521	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1116391020522	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1116391020523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1116391020524	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1116391020525	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1116391020526	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1116391020527	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1116391020528	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1116391020529	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1116391020530	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1116391020531	NAD binding site [chemical binding]; other site
1116391020532	homodimer interface [polypeptide binding]; other site
1116391020533	active site
1116391020534	substrate binding site [chemical binding]; other site
1116391020535	galactokinase; Provisional; Region: PRK05322
1116391020536	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1116391020537	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1116391020538	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1116391020539	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391020540	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391020541	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391020542	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391020543	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1116391020544	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391020545	dimer interface [polypeptide binding]; other site
1116391020546	phosphorylation site [posttranslational modification]
1116391020547	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391020548	ATP binding site [chemical binding]; other site
1116391020549	Mg2+ binding site [ion binding]; other site
1116391020550	G-X-G motif; other site
1116391020551	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391020552	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391020553	active site
1116391020554	phosphorylation site [posttranslational modification]
1116391020555	intermolecular recognition site; other site
1116391020556	dimerization interface [polypeptide binding]; other site
1116391020557	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391020558	DNA binding site [nucleotide binding]
1116391020559	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1116391020560	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1116391020561	RNA binding surface [nucleotide binding]; other site
1116391020562	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1116391020563	probable active site [active]
1116391020564	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1116391020565	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1116391020566	active site
1116391020567	Transglycosylase; Region: Transgly; pfam00912
1116391020568	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1116391020569	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1116391020570	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391020571	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391020572	putative substrate translocation pore; other site
1116391020573	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1116391020574	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391020575	putative substrate translocation pore; other site
1116391020576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391020577	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1116391020578	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391020579	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1116391020580	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391020581	motif II; other site
1116391020582	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1116391020583	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1116391020584	putative FMN binding site [chemical binding]; other site
1116391020585	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1116391020586	putative active site [active]
1116391020587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1116391020588	HTH-like domain; Region: HTH_21; pfam13276
1116391020589	Integrase core domain; Region: rve; pfam00665
1116391020590	Integrase core domain; Region: rve_2; pfam13333
1116391020591	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391020592	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1116391020593	Transposase; Region: HTH_Tnp_1; cl17663
1116391020594	Helix-turn-helix domain; Region: HTH_28; pfam13518
1116391020595	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1116391020596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391020597	putative substrate translocation pore; other site
1116391020598	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1116391020599	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391020600	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1116391020601	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1116391020602	E3 interaction surface; other site
1116391020603	lipoyl attachment site [posttranslational modification]; other site
1116391020604	HlyD family secretion protein; Region: HlyD_3; pfam13437
1116391020605	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391020606	MarR family; Region: MarR; pfam01047
1116391020607	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391020608	MarR family; Region: MarR_2; pfam12802
1116391020609	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1116391020610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391020611	S-adenosylmethionine binding site [chemical binding]; other site
1116391020612	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1116391020613	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1116391020614	xanthine permease; Region: pbuX; TIGR03173
1116391020615	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391020616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391020617	dimer interface [polypeptide binding]; other site
1116391020618	conserved gate region; other site
1116391020619	putative PBP binding loops; other site
1116391020620	ABC-ATPase subunit interface; other site
1116391020621	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391020622	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391020623	putative PBP binding loops; other site
1116391020624	dimer interface [polypeptide binding]; other site
1116391020625	ABC-ATPase subunit interface; other site
1116391020626	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391020627	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391020628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391020629	active site
1116391020630	phosphorylation site [posttranslational modification]
1116391020631	intermolecular recognition site; other site
1116391020632	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391020633	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391020634	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391020635	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391020636	dimerization interface [polypeptide binding]; other site
1116391020637	Histidine kinase; Region: His_kinase; pfam06580
1116391020638	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391020639	ATP binding site [chemical binding]; other site
1116391020640	Mg2+ binding site [ion binding]; other site
1116391020641	G-X-G motif; other site
1116391020642	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1116391020643	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1116391020644	dimerization interface [polypeptide binding]; other site
1116391020645	DPS ferroxidase diiron center [ion binding]; other site
1116391020646	ion pore; other site
1116391020647	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1116391020648	SpoOM protein; Region: Spo0M; pfam07070
1116391020649	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391020650	active site
1116391020651	substrate binding site [chemical binding]; other site
1116391020652	ATP binding site [chemical binding]; other site
1116391020653	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1116391020654	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1116391020655	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1116391020656	putative active site [active]
1116391020657	catalytic site [active]
1116391020658	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1116391020659	putative active site [active]
1116391020660	catalytic site [active]
1116391020661	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1116391020662	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1116391020663	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1116391020664	active site
1116391020665	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1116391020666	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391020667	putative DNA binding site [nucleotide binding]; other site
1116391020668	putative Zn2+ binding site [ion binding]; other site
1116391020669	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1116391020670	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1116391020671	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1116391020672	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1116391020673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391020674	non-specific DNA binding site [nucleotide binding]; other site
1116391020675	salt bridge; other site
1116391020676	sequence-specific DNA binding site [nucleotide binding]; other site
1116391020677	Cupin domain; Region: Cupin_2; pfam07883
1116391020678	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1116391020679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391020680	S-adenosylmethionine binding site [chemical binding]; other site
1116391020681	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1116391020682	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1116391020683	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1116391020684	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1116391020685	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1116391020686	apolar tunnel; other site
1116391020687	heme binding site [chemical binding]; other site
1116391020688	dimerization interface [polypeptide binding]; other site
1116391020689	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1116391020690	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1116391020691	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1116391020692	dimer interface [polypeptide binding]; other site
1116391020693	motif 1; other site
1116391020694	active site
1116391020695	motif 2; other site
1116391020696	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1116391020697	putative deacylase active site [active]
1116391020698	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1116391020699	active site
1116391020700	motif 3; other site
1116391020701	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1116391020702	anticodon binding site; other site
1116391020703	EcsC protein family; Region: EcsC; pfam12787
1116391020704	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1116391020705	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1116391020706	major capsid L1 protein; Provisional; Region: PHA02778
1116391020707	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1116391020708	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1116391020709	active site
1116391020710	HIGH motif; other site
1116391020711	nucleotide binding site [chemical binding]; other site
1116391020712	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1116391020713	KMSKS motif; other site
1116391020714	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1116391020715	GTPase RsgA; Reviewed; Region: PRK01889
1116391020716	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1116391020717	RNA binding site [nucleotide binding]; other site
1116391020718	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1116391020719	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1116391020720	GTP/Mg2+ binding site [chemical binding]; other site
1116391020721	G4 box; other site
1116391020722	G5 box; other site
1116391020723	G1 box; other site
1116391020724	Switch I region; other site
1116391020725	G2 box; other site
1116391020726	G3 box; other site
1116391020727	Switch II region; other site
1116391020728	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1116391020729	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1116391020730	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391020731	putative Zn2+ binding site [ion binding]; other site
1116391020732	putative DNA binding site [nucleotide binding]; other site
1116391020733	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1116391020734	Cache domain; Region: Cache_1; pfam02743
1116391020735	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391020736	dimerization interface [polypeptide binding]; other site
1116391020737	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391020738	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391020739	dimer interface [polypeptide binding]; other site
1116391020740	putative CheW interface [polypeptide binding]; other site
1116391020741	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1116391020742	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1116391020743	Glutamate binding site [chemical binding]; other site
1116391020744	homodimer interface [polypeptide binding]; other site
1116391020745	NAD binding site [chemical binding]; other site
1116391020746	catalytic residues [active]
1116391020747	Proline dehydrogenase; Region: Pro_dh; cl03282
1116391020748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1116391020749	PAS domain; Region: PAS_9; pfam13426
1116391020750	putative active site [active]
1116391020751	heme pocket [chemical binding]; other site
1116391020752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1116391020753	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1116391020754	Walker A motif; other site
1116391020755	ATP binding site [chemical binding]; other site
1116391020756	Walker B motif; other site
1116391020757	arginine finger; other site
1116391020758	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1116391020759	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1116391020760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391020761	active site
1116391020762	phosphorylation site [posttranslational modification]
1116391020763	intermolecular recognition site; other site
1116391020764	dimerization interface [polypeptide binding]; other site
1116391020765	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1116391020766	DNA binding residues [nucleotide binding]
1116391020767	dimerization interface [polypeptide binding]; other site
1116391020768	GAF domain; Region: GAF_2; pfam13185
1116391020769	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1116391020770	Histidine kinase; Region: HisKA_3; pfam07730
1116391020771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391020772	ATP binding site [chemical binding]; other site
1116391020773	Mg2+ binding site [ion binding]; other site
1116391020774	G-X-G motif; other site
1116391020775	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1116391020776	pentamer interface [polypeptide binding]; other site
1116391020777	dodecaamer interface [polypeptide binding]; other site
1116391020778	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1116391020779	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391020780	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1116391020781	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1116391020782	Coenzyme A binding pocket [chemical binding]; other site
1116391020783	Heat induced stress protein YflT; Region: YflT; pfam11181
1116391020784	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1116391020785	Catalytic site [active]
1116391020786	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1116391020787	SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249
1116391020788	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1116391020789	Fe-S cluster binding site [ion binding]; other site
1116391020790	active site
1116391020791	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1116391020792	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1116391020793	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1116391020794	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1116391020795	active site
1116391020796	Zn binding site [ion binding]; other site
1116391020797	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1116391020798	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1116391020799	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1116391020800	DEAD_2; Region: DEAD_2; pfam06733
1116391020801	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1116391020802	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1116391020803	MarR family; Region: MarR; pfam01047
1116391020804	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1116391020805	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391020806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1116391020807	Walker A/P-loop; other site
1116391020808	ATP binding site [chemical binding]; other site
1116391020809	Q-loop/lid; other site
1116391020810	ABC transporter signature motif; other site
1116391020811	Walker B; other site
1116391020812	D-loop; other site
1116391020813	H-loop/switch region; other site
1116391020814	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1116391020815	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1116391020816	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1116391020817	Walker A/P-loop; other site
1116391020818	ATP binding site [chemical binding]; other site
1116391020819	Q-loop/lid; other site
1116391020820	ABC transporter signature motif; other site
1116391020821	Walker B; other site
1116391020822	D-loop; other site
1116391020823	H-loop/switch region; other site
1116391020824	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
1116391020825	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1116391020826	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1116391020827	dimerization interface [polypeptide binding]; other site
1116391020828	DPS ferroxidase diiron center [ion binding]; other site
1116391020829	ion pore; other site
1116391020830	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1116391020831	metal binding site 2 [ion binding]; metal-binding site
1116391020832	putative DNA binding helix; other site
1116391020833	metal binding site 1 [ion binding]; metal-binding site
1116391020834	dimer interface [polypeptide binding]; other site
1116391020835	structural Zn2+ binding site [ion binding]; other site
1116391020836	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391020837	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391020838	DNA binding site [nucleotide binding]
1116391020839	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1116391020840	metal binding site 2 [ion binding]; metal-binding site
1116391020841	putative DNA binding helix; other site
1116391020842	metal binding site 1 [ion binding]; metal-binding site
1116391020843	dimer interface [polypeptide binding]; other site
1116391020844	structural Zn2+ binding site [ion binding]; other site
1116391020845	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1116391020846	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1116391020847	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
1116391020848	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1116391020849	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1116391020850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391020851	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1116391020852	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1116391020853	active site
1116391020854	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1116391020855	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391020856	dimer interface [polypeptide binding]; other site
1116391020857	conserved gate region; other site
1116391020858	putative PBP binding loops; other site
1116391020859	ABC-ATPase subunit interface; other site
1116391020860	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1116391020861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391020862	dimer interface [polypeptide binding]; other site
1116391020863	conserved gate region; other site
1116391020864	ABC-ATPase subunit interface; other site
1116391020865	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391020866	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391020867	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391020868	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391020869	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391020870	MAEBL; Provisional; Region: PTZ00121
1116391020871	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1116391020872	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391020873	dimerization interface [polypeptide binding]; other site
1116391020874	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391020875	dimer interface [polypeptide binding]; other site
1116391020876	phosphorylation site [posttranslational modification]
1116391020877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391020878	ATP binding site [chemical binding]; other site
1116391020879	Mg2+ binding site [ion binding]; other site
1116391020880	G-X-G motif; other site
1116391020881	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391020882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391020883	active site
1116391020884	phosphorylation site [posttranslational modification]
1116391020885	intermolecular recognition site; other site
1116391020886	dimerization interface [polypeptide binding]; other site
1116391020887	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391020888	DNA binding site [nucleotide binding]
1116391020889	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
1116391020890	non-specific DNA binding site [nucleotide binding]; other site
1116391020891	salt bridge; other site
1116391020892	sequence-specific DNA binding site [nucleotide binding]; other site
1116391020893	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1116391020894	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1116391020895	non-specific DNA binding site [nucleotide binding]; other site
1116391020896	salt bridge; other site
1116391020897	sequence-specific DNA binding site [nucleotide binding]; other site
1116391020898	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1116391020899	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1116391020900	Walker A/P-loop; other site
1116391020901	ATP binding site [chemical binding]; other site
1116391020902	Q-loop/lid; other site
1116391020903	ABC transporter signature motif; other site
1116391020904	Walker B; other site
1116391020905	D-loop; other site
1116391020906	H-loop/switch region; other site
1116391020907	PAS domain S-box; Region: sensory_box; TIGR00229
1116391020908	PAS domain; Region: PAS_8; pfam13188
1116391020909	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1116391020910	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1116391020911	metal binding site [ion binding]; metal-binding site
1116391020912	active site
1116391020913	I-site; other site
1116391020914	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1116391020915	Cache domain; Region: Cache_1; pfam02743
1116391020916	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391020917	dimerization interface [polypeptide binding]; other site
1116391020918	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391020919	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391020920	dimer interface [polypeptide binding]; other site
1116391020921	putative CheW interface [polypeptide binding]; other site
1116391020922	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391020923	Interdomain contacts; other site
1116391020924	Cytokine receptor motif; other site
1116391020925	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391020926	Interdomain contacts; other site
1116391020927	Cytokine receptor motif; other site
1116391020928	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1116391020929	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391020930	Interdomain contacts; other site
1116391020931	Cytokine receptor motif; other site
1116391020932	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1116391020933	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1116391020934	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1116391020935	DNA-binding site [nucleotide binding]; DNA binding site
1116391020936	RNA-binding motif; other site
1116391020937	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1116391020938	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1116391020939	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391020940	dimerization interface [polypeptide binding]; other site
1116391020941	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391020942	dimer interface [polypeptide binding]; other site
1116391020943	putative CheW interface [polypeptide binding]; other site
1116391020944	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1116391020945	glycerol kinase; Provisional; Region: glpK; PRK00047
1116391020946	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1116391020947	N- and C-terminal domain interface [polypeptide binding]; other site
1116391020948	active site
1116391020949	MgATP binding site [chemical binding]; other site
1116391020950	catalytic site [active]
1116391020951	metal binding site [ion binding]; metal-binding site
1116391020952	glycerol binding site [chemical binding]; other site
1116391020953	homotetramer interface [polypeptide binding]; other site
1116391020954	homodimer interface [polypeptide binding]; other site
1116391020955	FBP binding site [chemical binding]; other site
1116391020956	protein IIAGlc interface [polypeptide binding]; other site
1116391020957	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1116391020958	amphipathic channel; other site
1116391020959	Asn-Pro-Ala signature motifs; other site
1116391020960	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
1116391020961	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1116391020962	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1116391020963	putative ligand binding residues [chemical binding]; other site
1116391020964	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1116391020965	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1116391020966	Walker A/P-loop; other site
1116391020967	ATP binding site [chemical binding]; other site
1116391020968	Q-loop/lid; other site
1116391020969	ABC transporter signature motif; other site
1116391020970	Walker B; other site
1116391020971	D-loop; other site
1116391020972	H-loop/switch region; other site
1116391020973	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391020974	ABC-ATPase subunit  interface; other site
1116391020975	dimer interface [polypeptide binding]; other site
1116391020976	putative PBP binding regions; other site
1116391020977	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1116391020978	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1116391020979	ABC-ATPase subunit  interface; other site
1116391020980	dimer interface [polypeptide binding]; other site
1116391020981	putative PBP binding regions; other site
1116391020982	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1116391020983	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1116391020984	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1116391020985	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1116391020986	active site
1116391020987	HIGH motif; other site
1116391020988	nucleotide binding site [chemical binding]; other site
1116391020989	active site
1116391020990	KMSKS motif; other site
1116391020991	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1116391020992	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1116391020993	YceI-like domain; Region: YceI; pfam04264
1116391020994	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1116391020995	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1116391020996	short chain dehydrogenase; Provisional; Region: PRK06701
1116391020997	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1116391020998	NAD binding site [chemical binding]; other site
1116391020999	metal binding site [ion binding]; metal-binding site
1116391021000	active site
1116391021001	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1116391021002	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1116391021003	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391021004	dimerization interface [polypeptide binding]; other site
1116391021005	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1116391021006	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1116391021007	dimer interface [polypeptide binding]; other site
1116391021008	putative CheW interface [polypeptide binding]; other site
1116391021009	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1116391021010	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1116391021011	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1116391021012	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1116391021013	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1116391021014	Walker A/P-loop; other site
1116391021015	ATP binding site [chemical binding]; other site
1116391021016	Q-loop/lid; other site
1116391021017	ABC transporter signature motif; other site
1116391021018	Walker B; other site
1116391021019	D-loop; other site
1116391021020	H-loop/switch region; other site
1116391021021	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1116391021022	active site
1116391021023	catalytic triad [active]
1116391021024	oxyanion hole [active]
1116391021025	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1116391021026	EamA-like transporter family; Region: EamA; pfam00892
1116391021027	EamA-like transporter family; Region: EamA; pfam00892
1116391021028	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1116391021029	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1116391021030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1116391021031	hypothetical protein; Provisional; Region: PRK08236
1116391021032	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
1116391021033	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1116391021034	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1116391021035	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1116391021036	S-layer homology domain; Region: SLH; pfam00395
1116391021037	S-layer homology domain; Region: SLH; pfam00395
1116391021038	DNA Topoisomerase I (eukaryota); Region: TOPEUc; smart00435
1116391021039	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1116391021040	dimerization interface [polypeptide binding]; other site
1116391021041	putative DNA binding site [nucleotide binding]; other site
1116391021042	putative Zn2+ binding site [ion binding]; other site
1116391021043	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1116391021044	putative hydrophobic ligand binding site [chemical binding]; other site
1116391021045	Predicted transcriptional regulator [Transcription]; Region: COG1959
1116391021046	Transcriptional regulator; Region: Rrf2; pfam02082
1116391021047	MMPL family; Region: MMPL; pfam03176
1116391021048	MMPL family; Region: MMPL; pfam03176
1116391021049	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
1116391021050	Family description; Region: VCBS; pfam13517
1116391021051	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
1116391021052	putative inhibitory loop; other site
1116391021053	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391021054	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391021055	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391021056	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1116391021057	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1116391021058	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1116391021059	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1116391021060	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1116391021061	tetramer interface [polypeptide binding]; other site
1116391021062	active site
1116391021063	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1116391021064	active site
1116391021065	dimer interface [polypeptide binding]; other site
1116391021066	magnesium binding site [ion binding]; other site
1116391021067	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391021068	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391021069	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
1116391021070	classical (c) SDRs; Region: SDR_c; cd05233
1116391021071	NAD(P) binding site [chemical binding]; other site
1116391021072	active site
1116391021073	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1116391021074	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1116391021075	tetramer interface [polypeptide binding]; other site
1116391021076	heme binding pocket [chemical binding]; other site
1116391021077	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1116391021078	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391021079	S-adenosylmethionine binding site [chemical binding]; other site
1116391021080	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391021081	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1116391021082	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1116391021083	Walker A/P-loop; other site
1116391021084	ATP binding site [chemical binding]; other site
1116391021085	Q-loop/lid; other site
1116391021086	ABC transporter signature motif; other site
1116391021087	Walker B; other site
1116391021088	D-loop; other site
1116391021089	H-loop/switch region; other site
1116391021090	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1116391021091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1116391021092	dimer interface [polypeptide binding]; other site
1116391021093	conserved gate region; other site
1116391021094	putative PBP binding loops; other site
1116391021095	ABC-ATPase subunit interface; other site
1116391021096	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1116391021097	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1116391021098	substrate binding pocket [chemical binding]; other site
1116391021099	membrane-bound complex binding site; other site
1116391021100	hinge residues; other site
1116391021101	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1116391021102	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391021103	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1116391021104	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1116391021105	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1116391021106	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1116391021107	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1116391021108	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1116391021109	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391021110	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391021111	TPR repeat; Region: TPR_11; pfam13414
1116391021112	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1116391021113	active site
1116391021114	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1116391021115	DNA binding site [nucleotide binding]
1116391021116	active site
1116391021117	CsbD-like; Region: CsbD; pfam05532
1116391021118	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1116391021119	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1116391021120	S-adenosylmethionine binding site [chemical binding]; other site
1116391021121	Predicted transcriptional regulators [Transcription]; Region: COG1733
1116391021122	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1116391021123	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391021124	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391021125	putative substrate translocation pore; other site
1116391021126	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1116391021127	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1116391021128	active site
1116391021129	catalytic tetrad [active]
1116391021130	xanthine permease; Region: pbuX; TIGR03173
1116391021131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1116391021132	active site
1116391021133	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1116391021134	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391021135	putative substrate translocation pore; other site
1116391021136	POT family; Region: PTR2; cl17359
1116391021137	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1116391021138	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1116391021139	FeS/SAM binding site; other site
1116391021140	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1116391021141	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1116391021142	putative substrate translocation pore; other site
1116391021143	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1116391021144	GIY-YIG motif/motif A; other site
1116391021145	active site
1116391021146	catalytic site [active]
1116391021147	putative DNA binding site [nucleotide binding]; other site
1116391021148	metal binding site [ion binding]; metal-binding site
1116391021149	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1116391021150	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1116391021151	PhnA protein; Region: PhnA; pfam03831
1116391021152	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1116391021153	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1116391021154	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1116391021155	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1116391021156	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1116391021157	active site
1116391021158	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391021159	Interdomain contacts; other site
1116391021160	Cytokine receptor motif; other site
1116391021161	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1116391021162	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391021163	Interdomain contacts; other site
1116391021164	Cytokine receptor motif; other site
1116391021165	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1116391021166	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1116391021167	Interdomain contacts; other site
1116391021168	Cytokine receptor motif; other site
1116391021169	putative pectinesterase; Region: PLN02432; cl01911
1116391021170	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1116391021171	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1116391021172	Amb_all domain; Region: Amb_all; smart00656
1116391021173	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1116391021174	Predicted transcriptional regulator [Transcription]; Region: COG2378
1116391021175	HTH domain; Region: HTH_11; pfam08279
1116391021176	WYL domain; Region: WYL; pfam13280
1116391021177	hypothetical protein; Provisional; Region: PRK02268
1116391021178	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1116391021179	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1116391021180	ATP binding site [chemical binding]; other site
1116391021181	Mg++ binding site [ion binding]; other site
1116391021182	motif III; other site
1116391021183	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1116391021184	nucleotide binding region [chemical binding]; other site
1116391021185	ATP-binding site [chemical binding]; other site
1116391021186	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1116391021187	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1116391021188	dimerization interface [polypeptide binding]; other site
1116391021189	DPS ferroxidase diiron center [ion binding]; other site
1116391021190	ion pore; other site
1116391021191	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1116391021192	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1116391021193	TAP-like protein; Region: Abhydrolase_4; pfam08386
1116391021194	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391021195	ATP binding site [chemical binding]; other site
1116391021196	Mg2+ binding site [ion binding]; other site
1116391021197	G-X-G motif; other site
1116391021198	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1116391021199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391021200	active site
1116391021201	phosphorylation site [posttranslational modification]
1116391021202	intermolecular recognition site; other site
1116391021203	dimerization interface [polypeptide binding]; other site
1116391021204	LytTr DNA-binding domain; Region: LytTR; smart00850
1116391021205	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1116391021206	YyzF-like protein; Region: YyzF; pfam14116
1116391021207	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1116391021208	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1116391021209	protein binding site [polypeptide binding]; other site
1116391021210	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1116391021211	YycH protein; Region: YycI; cl02015
1116391021212	YycH protein; Region: YycH; pfam07435
1116391021213	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1116391021214	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1116391021215	dimerization interface [polypeptide binding]; other site
1116391021216	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1116391021217	putative active site [active]
1116391021218	heme pocket [chemical binding]; other site
1116391021219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1116391021220	dimer interface [polypeptide binding]; other site
1116391021221	phosphorylation site [posttranslational modification]
1116391021222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1116391021223	ATP binding site [chemical binding]; other site
1116391021224	Mg2+ binding site [ion binding]; other site
1116391021225	G-X-G motif; other site
1116391021226	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1116391021227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1116391021228	active site
1116391021229	phosphorylation site [posttranslational modification]
1116391021230	intermolecular recognition site; other site
1116391021231	dimerization interface [polypeptide binding]; other site
1116391021232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1116391021233	DNA binding site [nucleotide binding]
1116391021234	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1116391021235	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1116391021236	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1116391021237	G5 domain; Region: G5; pfam07501
1116391021238	Peptidase family M23; Region: Peptidase_M23; pfam01551
1116391021239	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1116391021240	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1116391021241	GDP-binding site [chemical binding]; other site
1116391021242	ACT binding site; other site
1116391021243	IMP binding site; other site
1116391021244	replicative DNA helicase; Provisional; Region: PRK05748
1116391021245	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1116391021246	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1116391021247	Walker A motif; other site
1116391021248	ATP binding site [chemical binding]; other site
1116391021249	Walker B motif; other site
1116391021250	DNA binding loops [nucleotide binding]
1116391021251	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1116391021252	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1116391021253	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1116391021254	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1116391021255	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1116391021256	DHH family; Region: DHH; pfam01368
1116391021257	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
1116391021258	MazG-like family; Region: MazG-like; pfam12643
1116391021259	FOG: CBS domain [General function prediction only]; Region: COG0517
1116391021260	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1116391021261	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1116391021262	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1116391021263	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1116391021264	dimer interface [polypeptide binding]; other site
1116391021265	ssDNA binding site [nucleotide binding]; other site
1116391021266	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1116391021267	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1116391021268	YjzC-like protein; Region: YjzC; pfam14168
1116391021269	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1116391021270	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1116391021271	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1116391021272	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1116391021273	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
1116391021274	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1116391021275	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1116391021276	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1116391021277	catalytic residue [active]
1116391021278	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1116391021279	ParB-like nuclease domain; Region: ParB; smart00470
1116391021280	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1116391021281	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1116391021282	P-loop; other site
1116391021283	Magnesium ion binding site [ion binding]; other site
1116391021284	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1116391021285	Magnesium ion binding site [ion binding]; other site
1116391021286	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1116391021287	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1116391021288	ParB-like nuclease domain; Region: ParB; smart00470
1116391021289	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1116391021290	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1116391021291	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1116391021292	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1116391021293	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1116391021294	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1116391021295	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1116391021296	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1116391021297	G1 box; other site
1116391021298	GTP/Mg2+ binding site [chemical binding]; other site
1116391021299	Switch I region; other site
1116391021300	G2 box; other site
1116391021301	Switch II region; other site
1116391021302	G3 box; other site
1116391021303	G4 box; other site
1116391021304	G5 box; other site
1116391021305	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1116391021306	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1116391021307	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1116391021308	G-X-X-G motif; other site
1116391021309	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1116391021310	RxxxH motif; other site
1116391021311	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1116391021312	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1116391021313	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399