-- dump date 20140619_224902 -- class Genbank::misc_feature -- table misc_feature_note -- id note 693746000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746000003 P-loop; other site 693746000004 Magnesium ion binding site [ion binding]; other site 693746000005 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693746000006 ParB-like nuclease domain; Region: ParBc; pfam02195 693746000007 RelB antitoxin; Region: RelB; cl01171 693746000008 RelB antitoxin; Region: RelB; cl01171 693746000009 CHC2 zinc finger; Region: zf-CHC2; cl17510 693746000010 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 693746000011 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 693746000012 active site 693746000013 metal binding site [ion binding]; metal-binding site 693746000014 interdomain interaction site; other site 693746000015 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746000016 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693746000017 catalytic residues [active] 693746000018 catalytic nucleophile [active] 693746000019 Presynaptic Site I dimer interface [polypeptide binding]; other site 693746000020 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693746000021 Synaptic Flat tetramer interface [polypeptide binding]; other site 693746000022 Synaptic Site I dimer interface [polypeptide binding]; other site 693746000023 DNA binding site [nucleotide binding] 693746000024 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 693746000025 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693746000026 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693746000027 Catalytic site [active] 693746000028 MAEBL; Provisional; Region: PTZ00121 693746000029 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 693746000030 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746000031 DsrE/DsrF-like family; Region: DrsE; pfam02635 693746000032 rRNA processing; Region: rRNA_processing; pfam08524 693746000033 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 693746000034 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746000035 Walker A motif; other site 693746000036 ATP binding site [chemical binding]; other site 693746000037 Walker B motif; other site 693746000038 PrgI family protein; Region: PrgI; pfam12666 693746000039 AAA-like domain; Region: AAA_10; pfam12846 693746000040 Domain of unknown function DUF87; Region: DUF87; cl19135 693746000041 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 693746000042 Putative amidase domain; Region: Amidase_6; pfam12671 693746000043 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746000044 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746000045 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746000046 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746000047 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746000048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746000049 DNA-binding site [nucleotide binding]; DNA binding site 693746000050 DNA topoisomerase I/SWI domain fusion protein; Validated; Region: PRK06319 693746000051 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693746000052 DNA topoisomerase III; Provisional; Region: PRK07726 693746000053 active site 693746000054 putative interdomain interaction site [polypeptide binding]; other site 693746000055 putative metal-binding site [ion binding]; other site 693746000056 putative nucleotide binding site [chemical binding]; other site 693746000057 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693746000058 domain I; other site 693746000059 DNA binding groove [nucleotide binding] 693746000060 phosphate binding site [ion binding]; other site 693746000061 domain II; other site 693746000062 domain III; other site 693746000063 nucleotide binding site [chemical binding]; other site 693746000064 catalytic site [active] 693746000065 domain IV; other site 693746000066 Domain of unknown function (DUF955); Region: DUF955; cl01076 693746000067 histone-like DNA-binding protein HU; Region: HU; cd13831 693746000068 dimer interface [polypeptide binding]; other site 693746000069 DNA binding site [nucleotide binding] 693746000070 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 693746000071 Domain of unknown function (DUF932); Region: DUF932; cl12129 693746000072 TraX protein; Region: TraX; cl05434 693746000073 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 693746000074 DnaA N-terminal domain; Region: DnaA_N; pfam11638 693746000075 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 693746000076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746000077 Walker A motif; other site 693746000078 ATP binding site [chemical binding]; other site 693746000079 Walker B motif; other site 693746000080 arginine finger; other site 693746000081 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 693746000082 DnaA box-binding interface [nucleotide binding]; other site 693746000083 DNA polymerase III subunit beta; Validated; Region: PRK05643 693746000084 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693746000085 putative DNA binding surface [nucleotide binding]; other site 693746000086 dimer interface [polypeptide binding]; other site 693746000087 beta-clamp/clamp loader binding surface; other site 693746000088 beta-clamp/translesion DNA polymerase binding surface; other site 693746000089 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746000090 RNA binding surface [nucleotide binding]; other site 693746000091 recombination protein F; Reviewed; Region: recF; PRK00064 693746000092 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746000093 Walker A/P-loop; other site 693746000094 ATP binding site [chemical binding]; other site 693746000095 Q-loop/lid; other site 693746000096 ABC transporter signature motif; other site 693746000097 Walker B; other site 693746000098 D-loop; other site 693746000099 H-loop/switch region; other site 693746000100 Domain of unknown function (DUF370); Region: DUF370; cl00898 693746000101 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 693746000102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000103 ATP binding site [chemical binding]; other site 693746000104 Mg2+ binding site [ion binding]; other site 693746000105 G-X-G motif; other site 693746000106 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 693746000107 anchoring element; other site 693746000108 dimer interface [polypeptide binding]; other site 693746000109 ATP binding site [chemical binding]; other site 693746000110 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 693746000111 active site 693746000112 putative metal-binding site [ion binding]; other site 693746000113 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693746000114 DNA gyrase subunit A; Validated; Region: PRK05560 693746000115 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693746000116 CAP-like domain; other site 693746000117 active site 693746000118 primary dimer interface [polypeptide binding]; other site 693746000119 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693746000120 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693746000121 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693746000122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693746000123 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693746000124 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 693746000125 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 693746000126 RNA/DNA hybrid binding site [nucleotide binding]; other site 693746000127 active site 693746000128 NAD synthetase; Reviewed; Region: nadE; PRK02628 693746000129 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 693746000130 multimer interface [polypeptide binding]; other site 693746000131 active site 693746000132 catalytic triad [active] 693746000133 protein interface 1 [polypeptide binding]; other site 693746000134 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 693746000135 homodimer interface [polypeptide binding]; other site 693746000136 NAD binding pocket [chemical binding]; other site 693746000137 ATP binding pocket [chemical binding]; other site 693746000138 Mg binding site [ion binding]; other site 693746000139 active-site loop [active] 693746000140 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 693746000141 Germination protease; Region: Peptidase_A25; cl04057 693746000142 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 693746000143 active site 693746000144 putative catalytic site [active] 693746000145 DNA binding site [nucleotide binding] 693746000146 putative phosphate binding site [ion binding]; other site 693746000147 metal binding site A [ion binding]; metal-binding site 693746000148 AP binding site [nucleotide binding]; other site 693746000149 metal binding site B [ion binding]; metal-binding site 693746000150 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746000151 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 693746000152 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 693746000153 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 693746000154 active site 693746000155 HIGH motif; other site 693746000156 KMSKS motif; other site 693746000157 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 693746000158 tRNA binding surface [nucleotide binding]; other site 693746000159 anticodon binding site; other site 693746000160 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 693746000161 dimer interface [polypeptide binding]; other site 693746000162 putative tRNA-binding site [nucleotide binding]; other site 693746000163 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 693746000164 active site 693746000165 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693746000166 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746000167 FeS/SAM binding site; other site 693746000168 stage II sporulation protein P; Region: spore_II_P; TIGR02867 693746000169 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 693746000170 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 693746000171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746000172 FeS/SAM binding site; other site 693746000173 HemN C-terminal domain; Region: HemN_C; pfam06969 693746000174 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 693746000175 CoenzymeA binding site [chemical binding]; other site 693746000176 subunit interaction site [polypeptide binding]; other site 693746000177 PHB binding site; other site 693746000178 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746000179 dimerization interface [polypeptide binding]; other site 693746000180 putative DNA binding site [nucleotide binding]; other site 693746000181 putative Zn2+ binding site [ion binding]; other site 693746000182 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693746000183 metal-binding site [ion binding] 693746000184 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 693746000185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693746000186 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693746000187 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693746000188 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 693746000189 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 693746000190 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 693746000191 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693746000192 Uncharacterized conserved protein [Function unknown]; Region: COG1284 693746000193 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693746000194 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693746000195 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 693746000196 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 693746000197 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 693746000198 CAP-like domain; other site 693746000199 active site 693746000200 primary dimer interface [polypeptide binding]; other site 693746000201 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 693746000202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000203 Mg2+ binding site [ion binding]; other site 693746000204 G-X-G motif; other site 693746000205 DNA gyrase B; Region: DNA_gyraseB; pfam00204 693746000206 ATP binding site [chemical binding]; other site 693746000207 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 693746000208 active site 693746000209 putative metal-binding site [ion binding]; other site 693746000210 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 693746000211 SpoVA protein; Region: SpoVA; cl04298 693746000212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746000213 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746000214 dimer interface [polypeptide binding]; other site 693746000215 phosphorylation site [posttranslational modification] 693746000216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000217 ATP binding site [chemical binding]; other site 693746000218 Mg2+ binding site [ion binding]; other site 693746000219 G-X-G motif; other site 693746000220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746000221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746000222 active site 693746000223 phosphorylation site [posttranslational modification] 693746000224 intermolecular recognition site; other site 693746000225 dimerization interface [polypeptide binding]; other site 693746000226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746000227 DNA binding site [nucleotide binding] 693746000228 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 693746000229 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 693746000230 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 693746000231 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693746000232 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746000233 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746000234 Walker A/P-loop; other site 693746000235 ATP binding site [chemical binding]; other site 693746000236 Q-loop/lid; other site 693746000237 ABC transporter signature motif; other site 693746000238 Walker B; other site 693746000239 D-loop; other site 693746000240 H-loop/switch region; other site 693746000241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746000242 metal binding site [ion binding]; metal-binding site 693746000243 active site 693746000244 I-site; other site 693746000245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746000246 HTH-like domain; Region: HTH_21; pfam13276 693746000247 Integrase core domain; Region: rve; pfam00665 693746000248 Integrase core domain; Region: rve_3; pfam13683 693746000249 Transposase; Region: HTH_Tnp_1; cl17663 693746000250 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746000251 Transposase domain (DUF772); Region: DUF772; pfam05598 693746000252 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 693746000253 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746000254 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746000255 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 693746000256 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 693746000257 S-layer homology domain; Region: SLH; pfam00395 693746000258 S-layer homology domain; Region: SLH; pfam00395 693746000259 S-layer homology domain; Region: SLH; pfam00395 693746000260 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 693746000261 Protein of unknown function (DUF975); Region: DUF975; cl10504 693746000262 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 693746000263 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 693746000264 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 693746000265 SLBB domain; Region: SLBB; pfam10531 693746000266 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693746000267 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 693746000268 FMN-binding domain; Region: FMN_bind; cl01081 693746000269 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 693746000270 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 693746000271 ferredoxin; Validated; Region: PRK07118 693746000272 Putative Fe-S cluster; Region: FeS; cl17515 693746000273 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746000274 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693746000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746000276 non-specific DNA binding site [nucleotide binding]; other site 693746000277 salt bridge; other site 693746000278 sequence-specific DNA binding site [nucleotide binding]; other site 693746000279 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 693746000280 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693746000281 HrcA protein C terminal domain; Region: HrcA; pfam01628 693746000282 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 693746000283 dimer interface [polypeptide binding]; other site 693746000284 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 693746000285 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 693746000286 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 693746000287 nucleotide binding site [chemical binding]; other site 693746000288 NEF interaction site [polypeptide binding]; other site 693746000289 SBD interface [polypeptide binding]; other site 693746000290 chaperone protein DnaJ; Provisional; Region: PRK14277 693746000291 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693746000292 HSP70 interaction site [polypeptide binding]; other site 693746000293 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 693746000294 substrate binding site [polypeptide binding]; other site 693746000295 dimer interface [polypeptide binding]; other site 693746000296 histidinol-phosphatase; Provisional; Region: PRK07328 693746000297 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 693746000298 active site 693746000299 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 693746000300 Putative glycosyl hydrolase domain; Region: DUF4015; cl17870 693746000301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746000302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746000303 active site 693746000304 phosphorylation site [posttranslational modification] 693746000305 intermolecular recognition site; other site 693746000306 dimerization interface [polypeptide binding]; other site 693746000307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746000308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746000309 dimer interface [polypeptide binding]; other site 693746000310 phosphorylation site [posttranslational modification] 693746000311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000312 ATP binding site [chemical binding]; other site 693746000313 Mg2+ binding site [ion binding]; other site 693746000314 G-X-G motif; other site 693746000315 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693746000316 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693746000317 inhibitor-cofactor binding pocket; inhibition site 693746000318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746000319 catalytic residue [active] 693746000320 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 693746000321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746000322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746000323 homodimer interface [polypeptide binding]; other site 693746000324 catalytic residue [active] 693746000325 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 693746000326 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693746000327 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 693746000328 iron binding site [ion binding]; other site 693746000329 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 693746000330 Rubrerythrin [Energy production and conversion]; Region: COG1592 693746000331 diiron binding motif [ion binding]; other site 693746000332 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 693746000333 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 693746000334 threonine dehydratase; Provisional; Region: PRK08198 693746000335 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693746000336 tetramer interface [polypeptide binding]; other site 693746000337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746000338 catalytic residue [active] 693746000339 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 693746000340 Transposase; Region: HTH_Tnp_1; cl17663 693746000341 potential frameshift: common BLAST hit: gi|317055248|ref|YP_004103715.1| integrase catalytic subunit 693746000342 HTH-like domain; Region: HTH_21; pfam13276 693746000343 potential frameshift: common BLAST hit: gi|150016902|ref|YP_001309156.1| integrase catalytic subunit 693746000344 Integrase core domain; Region: rve; pfam00665 693746000345 Integrase core domain; Region: rve_3; cl15866 693746000346 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746000347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746000348 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746000349 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693746000350 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693746000351 ABC-ATPase subunit interface; other site 693746000352 dimer interface [polypeptide binding]; other site 693746000353 putative PBP binding regions; other site 693746000354 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693746000355 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693746000356 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 693746000357 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693746000358 intersubunit interface [polypeptide binding]; other site 693746000359 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 693746000360 metal binding site 2 [ion binding]; metal-binding site 693746000361 putative DNA binding helix; other site 693746000362 metal binding site 1 [ion binding]; metal-binding site 693746000363 dimer interface [polypeptide binding]; other site 693746000364 structural Zn2+ binding site [ion binding]; other site 693746000365 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 693746000366 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 693746000367 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693746000368 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693746000369 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 693746000370 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693746000371 Bacterial transcriptional regulator; Region: IclR; pfam01614 693746000372 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746000373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746000374 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746000375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746000376 homodimer interface [polypeptide binding]; other site 693746000377 catalytic residue [active] 693746000378 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693746000379 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746000380 dimer interface [polypeptide binding]; other site 693746000381 PYR/PP interface [polypeptide binding]; other site 693746000382 TPP binding site [chemical binding]; other site 693746000383 substrate binding site [chemical binding]; other site 693746000384 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693746000385 Domain of unknown function; Region: EKR; smart00890 693746000386 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746000387 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 693746000388 TPP-binding site [chemical binding]; other site 693746000389 dimer interface [polypeptide binding]; other site 693746000390 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693746000391 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 693746000392 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693746000393 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693746000394 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746000395 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 693746000396 Predicted membrane protein [Function unknown]; Region: COG2855 693746000397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746000398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746000399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746000400 dimerization interface [polypeptide binding]; other site 693746000401 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693746000402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746000403 S-adenosylmethionine binding site [chemical binding]; other site 693746000404 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746000405 Zn2+ binding site [ion binding]; other site 693746000406 Mg2+ binding site [ion binding]; other site 693746000407 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746000408 Zn2+ binding site [ion binding]; other site 693746000409 Mg2+ binding site [ion binding]; other site 693746000410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693746000411 catalytic residues [active] 693746000412 4Fe-4S binding domain; Region: Fer4; pfam00037 693746000413 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 693746000414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746000415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746000416 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693746000417 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 693746000418 active site residue [active] 693746000419 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 693746000420 CPxP motif; other site 693746000421 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 693746000422 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693746000423 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693746000424 ligand binding site [chemical binding]; other site 693746000425 flexible hinge region; other site 693746000426 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 693746000427 putative switch regulator; other site 693746000428 non-specific DNA interactions [nucleotide binding]; other site 693746000429 DNA binding site [nucleotide binding] 693746000430 sequence specific DNA binding site [nucleotide binding]; other site 693746000431 putative cAMP binding site [chemical binding]; other site 693746000432 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 693746000433 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 693746000434 catalytic motif [active] 693746000435 Zn binding site [ion binding]; other site 693746000436 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 693746000437 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 693746000438 Lumazine binding domain; Region: Lum_binding; pfam00677 693746000439 Lumazine binding domain; Region: Lum_binding; pfam00677 693746000440 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 693746000441 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 693746000442 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 693746000443 dimerization interface [polypeptide binding]; other site 693746000444 active site 693746000445 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 693746000446 homopentamer interface [polypeptide binding]; other site 693746000447 active site 693746000448 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746000449 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746000450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746000451 active site 693746000452 phosphorylation site [posttranslational modification] 693746000453 intermolecular recognition site; other site 693746000454 dimerization interface [polypeptide binding]; other site 693746000455 LytTr DNA-binding domain; Region: LytTR; pfam04397 693746000456 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 693746000457 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 693746000458 GAF domain; Region: GAF; cl17456 693746000459 Histidine kinase; Region: His_kinase; pfam06580 693746000460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000461 ATP binding site [chemical binding]; other site 693746000462 Mg2+ binding site [ion binding]; other site 693746000463 G-X-G motif; other site 693746000464 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693746000465 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693746000466 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 693746000467 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 693746000468 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693746000469 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 693746000470 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 693746000471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746000472 Walker A/P-loop; other site 693746000473 ATP binding site [chemical binding]; other site 693746000474 Q-loop/lid; other site 693746000475 ABC transporter signature motif; other site 693746000476 Walker B; other site 693746000477 D-loop; other site 693746000478 H-loop/switch region; other site 693746000479 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 693746000480 TM-ABC transporter signature motif; other site 693746000481 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 693746000482 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693746000483 zinc binding site [ion binding]; other site 693746000484 putative ligand binding site [chemical binding]; other site 693746000485 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 693746000486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746000487 Walker A/P-loop; other site 693746000488 ATP binding site [chemical binding]; other site 693746000489 Q-loop/lid; other site 693746000490 ABC transporter signature motif; other site 693746000491 Walker B; other site 693746000492 D-loop; other site 693746000493 H-loop/switch region; other site 693746000494 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 693746000495 TM-ABC transporter signature motif; other site 693746000496 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 693746000497 zinc binding site [ion binding]; other site 693746000498 putative ligand binding site [chemical binding]; other site 693746000499 CTP synthetase; Validated; Region: pyrG; PRK05380 693746000500 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 693746000501 Catalytic site [active] 693746000502 active site 693746000503 UTP binding site [chemical binding]; other site 693746000504 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 693746000505 active site 693746000506 putative oxyanion hole; other site 693746000507 catalytic triad [active] 693746000508 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 693746000509 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 693746000510 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 693746000511 active site 693746000512 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 693746000513 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693746000514 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693746000515 Bacterial transcriptional regulator; Region: IclR; pfam01614 693746000516 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693746000517 oligomerization interface [polypeptide binding]; other site 693746000518 active site 693746000519 metal binding site [ion binding]; metal-binding site 693746000520 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693746000521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746000522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746000523 homodimer interface [polypeptide binding]; other site 693746000524 catalytic residue [active] 693746000525 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746000526 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746000527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746000528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746000529 active site 693746000530 phosphorylation site [posttranslational modification] 693746000531 intermolecular recognition site; other site 693746000532 dimerization interface [polypeptide binding]; other site 693746000533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746000534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746000535 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 693746000536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746000537 nucleophilic elbow; other site 693746000538 catalytic triad; other site 693746000539 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746000540 NlpC/P60 family; Region: NLPC_P60; cl17555 693746000541 Holin family; Region: Phage_holin_4; cl01989 693746000542 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746000543 Phage terminase large subunit; Region: Terminase_3; cl12054 693746000544 Terminase-like family; Region: Terminase_6; pfam03237 693746000545 Fn3 associated; Region: Fn3_assoc; pfam13287 693746000546 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 693746000547 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 693746000548 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746000549 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 693746000550 ATP binding site [chemical binding]; other site 693746000551 putative Mg++ binding site [ion binding]; other site 693746000552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746000553 nucleotide binding region [chemical binding]; other site 693746000554 ATP-binding site [chemical binding]; other site 693746000555 VRR-NUC domain; Region: VRR_NUC; pfam08774 693746000556 Virulence-associated protein E; Region: VirE; pfam05272 693746000557 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 693746000558 active site 693746000559 DNA binding site [nucleotide binding] 693746000560 catalytic site [active] 693746000561 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 693746000562 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 693746000563 HNH endonuclease; Region: HNH_3; pfam13392 693746000564 AP2 domain; Region: AP2; pfam00847 693746000565 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693746000566 cofactor binding site; other site 693746000567 DNA binding site [nucleotide binding] 693746000568 substrate interaction site [chemical binding]; other site 693746000569 potential protein location (hypothetical protein) that overlaps protein (putative methyltransferase) 693746000570 3D domain; Region: 3D; cl01439 693746000571 nickel responsive regulator; Provisional; Region: PRK02967 693746000572 Predicted transcriptional regulator [Transcription]; Region: COG2932 693746000573 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693746000574 Catalytic site [active] 693746000575 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693746000576 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000577 active site 693746000578 DNA binding site [nucleotide binding] 693746000579 Int/Topo IB signature motif; other site 693746000580 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746000581 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 693746000582 metal binding site [ion binding]; metal-binding site 693746000583 putative dimer interface [polypeptide binding]; other site 693746000584 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693746000585 Sensory domain found in PocR; Region: PocR; pfam10114 693746000586 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746000587 putative CheW interface [polypeptide binding]; other site 693746000588 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746000589 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746000590 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746000591 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693746000592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746000593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746000594 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693746000595 active site 693746000596 metal binding site [ion binding]; metal-binding site 693746000597 CAAX protease self-immunity; Region: Abi; pfam02517 693746000598 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693746000599 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746000600 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 693746000601 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 693746000602 Walker A/P-loop; other site 693746000603 ATP binding site [chemical binding]; other site 693746000604 Q-loop/lid; other site 693746000605 ABC transporter signature motif; other site 693746000606 Walker B; other site 693746000607 D-loop; other site 693746000608 H-loop/switch region; other site 693746000609 Protein of unknown function, DUF624; Region: DUF624; cl02369 693746000610 Protein of unknown function, DUF624; Region: DUF624; cl02369 693746000611 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693746000612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693746000613 nucleotide binding site [chemical binding]; other site 693746000614 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 693746000615 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693746000616 dimer interface [polypeptide binding]; other site 693746000617 active site 693746000618 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693746000619 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 693746000620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746000621 dimer interface [polypeptide binding]; other site 693746000622 conserved gate region; other site 693746000623 putative PBP binding loops; other site 693746000624 ABC-ATPase subunit interface; other site 693746000625 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 693746000626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746000627 dimer interface [polypeptide binding]; other site 693746000628 conserved gate region; other site 693746000629 putative PBP binding loops; other site 693746000630 ABC-ATPase subunit interface; other site 693746000631 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 693746000632 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693746000633 dimer interface [polypeptide binding]; other site 693746000634 substrate binding site [chemical binding]; other site 693746000635 ATP binding site [chemical binding]; other site 693746000636 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 693746000637 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 693746000638 Walker A/P-loop; other site 693746000639 ATP binding site [chemical binding]; other site 693746000640 Q-loop/lid; other site 693746000641 ABC transporter signature motif; other site 693746000642 Walker B; other site 693746000643 D-loop; other site 693746000644 H-loop/switch region; other site 693746000645 TOBE domain; Region: TOBE_2; pfam08402 693746000646 potential frameshift: common BLAST hit: gi|334339999|ref|YP_004544979.1| peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid 693746000647 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 693746000648 active site 693746000649 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 693746000650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746000651 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 693746000652 DNA binding site [nucleotide binding] 693746000653 catalytic residue [active] 693746000654 formamidopyrimidine-DNA glycosylase (fpg); Region: fpg; TIGR00577 693746000655 H2TH interface [polypeptide binding]; other site 693746000656 putative catalytic residues [active] 693746000657 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 693746000658 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 693746000659 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 693746000660 active site 693746000661 NTP binding site [chemical binding]; other site 693746000662 metal binding triad [ion binding]; metal-binding site 693746000663 AAA domain; Region: AAA_18; pfam13238 693746000664 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 693746000665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746000666 non-specific DNA binding site [nucleotide binding]; other site 693746000667 salt bridge; other site 693746000668 sequence-specific DNA binding site [nucleotide binding]; other site 693746000669 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000670 S-layer homology domain; Region: SLH; pfam00395 693746000671 S-layer homology domain; Region: SLH; pfam00395 693746000672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746000673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746000674 non-specific DNA binding site [nucleotide binding]; other site 693746000675 salt bridge; other site 693746000676 sequence-specific DNA binding site [nucleotide binding]; other site 693746000677 SprT-like family; Region: SprT-like; pfam10263 693746000678 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693746000679 Putative viral replication protein; Region: Viral_Rep; pfam02407 693746000680 RNA helicase; Region: RNA_helicase; pfam00910 693746000681 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693746000682 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746000683 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746000684 Int/Topo IB signature motif; other site 693746000685 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 693746000686 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 693746000687 Ligand Binding Site [chemical binding]; other site 693746000688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746000689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000690 ATP binding site [chemical binding]; other site 693746000691 Mg2+ binding site [ion binding]; other site 693746000692 G-X-G motif; other site 693746000693 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693746000694 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 693746000695 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693746000696 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 693746000697 30S subunit binding site; other site 693746000698 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746000699 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693746000700 G5 domain; Region: G5; pfam07501 693746000701 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746000702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746000703 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746000704 Walker A/P-loop; other site 693746000705 ATP binding site [chemical binding]; other site 693746000706 Q-loop/lid; other site 693746000707 ABC transporter signature motif; other site 693746000708 Walker B; other site 693746000709 D-loop; other site 693746000710 H-loop/switch region; other site 693746000711 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693746000712 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746000713 FtsX-like permease family; Region: FtsX; pfam02687 693746000714 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746000715 FtsX-like permease family; Region: FtsX; pfam02687 693746000716 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693746000717 HlyD family secretion protein; Region: HlyD_3; pfam13437 693746000718 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693746000719 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693746000720 carboxyltransferase (CT) interaction site; other site 693746000721 biotinylation site [posttranslational modification]; other site 693746000722 HlyD family secretion protein; Region: HlyD_3; pfam13437 693746000723 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746000724 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746000725 Walker A/P-loop; other site 693746000726 ATP binding site [chemical binding]; other site 693746000727 Q-loop/lid; other site 693746000728 ABC transporter signature motif; other site 693746000729 Walker B; other site 693746000730 D-loop; other site 693746000731 H-loop/switch region; other site 693746000732 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693746000733 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746000734 FtsX-like permease family; Region: FtsX; pfam02687 693746000735 S-layer homology domain; Region: SLH; pfam00395 693746000736 S-layer homology domain; Region: SLH; pfam00395 693746000737 Lamin Tail Domain; Region: LTD; pfam00932 693746000738 SnoaL-like domain; Region: SnoaL_2; pfam12680 693746000739 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 693746000740 active site 693746000741 metal binding site [ion binding]; metal-binding site 693746000742 homotetramer interface [polypeptide binding]; other site 693746000743 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 693746000744 active site 693746000745 nucleotide binding site [chemical binding]; other site 693746000746 HIGH motif; other site 693746000747 KMSKS motif; other site 693746000748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746000749 non-specific DNA binding site [nucleotide binding]; other site 693746000750 salt bridge; other site 693746000751 sequence-specific DNA binding site [nucleotide binding]; other site 693746000752 Predicted transcriptional regulator [Transcription]; Region: COG2932 693746000753 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693746000754 Catalytic site [active] 693746000755 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746000756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746000757 DNA binding residues [nucleotide binding] 693746000758 Uncharacterized conserved protein [Function unknown]; Region: COG1284 693746000759 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693746000760 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 693746000761 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 693746000762 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693746000763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746000764 active site 693746000765 motif I; other site 693746000766 motif II; other site 693746000767 hypothetical protein; Provisional; Region: PRK05807 693746000768 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 693746000769 RNA binding site [nucleotide binding]; other site 693746000770 Septum formation initiator; Region: DivIC; cl17659 693746000771 YabP family; Region: YabP; pfam07873 693746000772 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746000773 RNA binding surface [nucleotide binding]; other site 693746000774 histone-like DNA-binding protein HU; Region: HU; cd13831 693746000775 dimer interface [polypeptide binding]; other site 693746000776 DNA binding site [nucleotide binding] 693746000777 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 693746000778 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 693746000779 homodimer interface [polypeptide binding]; other site 693746000780 metal binding site [ion binding]; metal-binding site 693746000781 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 693746000782 homodimer interface [polypeptide binding]; other site 693746000783 active site 693746000784 putative chemical substrate binding site [chemical binding]; other site 693746000785 metal binding site [ion binding]; metal-binding site 693746000786 stage V sporulation protein B; Region: spore_V_B; TIGR02900 693746000787 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 693746000788 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 693746000789 Double zinc ribbon; Region: DZR; pfam12773 693746000790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693746000791 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 693746000792 active site 693746000793 coproporphyrinogen dehydrogenase HemZ; Region: rSAM_HemZ; TIGR03994 693746000794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746000795 FeS/SAM binding site; other site 693746000796 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693746000797 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 693746000798 putative active site [active] 693746000799 dimerization interface [polypeptide binding]; other site 693746000800 putative tRNAtyr binding site [nucleotide binding]; other site 693746000801 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 693746000802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746000803 Zn2+ binding site [ion binding]; other site 693746000804 Mg2+ binding site [ion binding]; other site 693746000805 IncFII RepA protein family; Region: IncFII_repA; cl11495 693746000806 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 693746000807 synthetase active site [active] 693746000808 NTP binding site [chemical binding]; other site 693746000809 metal binding site [ion binding]; metal-binding site 693746000810 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 693746000811 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 693746000812 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 693746000813 DHH family; Region: DHH; pfam01368 693746000814 DHHA1 domain; Region: DHHA1; pfam02272 693746000815 S-layer homology domain; Region: SLH; pfam00395 693746000816 S-layer homology domain; Region: SLH; pfam00395 693746000817 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693746000818 active site 693746000819 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 693746000820 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 693746000821 active site 693746000822 dimer interface [polypeptide binding]; other site 693746000823 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 693746000824 dimer interface [polypeptide binding]; other site 693746000825 active site 693746000826 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 693746000827 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 693746000828 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693746000829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746000830 non-specific DNA binding site [nucleotide binding]; other site 693746000831 salt bridge; other site 693746000832 sequence-specific DNA binding site [nucleotide binding]; other site 693746000833 Predicted membrane protein [Function unknown]; Region: COG1288 693746000834 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 693746000835 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746000836 metal binding site [ion binding]; metal-binding site 693746000837 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 693746000838 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693746000839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746000840 DNA-binding site [nucleotide binding]; DNA binding site 693746000841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746000842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746000843 homodimer interface [polypeptide binding]; other site 693746000844 catalytic residue [active] 693746000845 putative acyltransferase; Provisional; Region: PRK05790 693746000846 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693746000847 dimer interface [polypeptide binding]; other site 693746000848 active site 693746000849 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 693746000850 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693746000851 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693746000852 Catalytic site [active] 693746000853 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 693746000854 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 693746000855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746000856 ATP binding site [chemical binding]; other site 693746000857 putative Mg++ binding site [ion binding]; other site 693746000858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746000859 nucleotide binding region [chemical binding]; other site 693746000860 ATP-binding site [chemical binding]; other site 693746000861 TRCF domain; Region: TRCF; pfam03461 693746000862 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 693746000863 putative active site [active] 693746000864 catalytic residue [active] 693746000865 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 693746000866 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746000867 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 693746000868 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 693746000869 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746000870 active site 693746000871 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 693746000872 active site 693746000873 substrate binding site [chemical binding]; other site 693746000874 CoA binding site [chemical binding]; other site 693746000875 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 693746000876 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 693746000877 substrate binding site [chemical binding]; other site 693746000878 hinge regions; other site 693746000879 ADP binding site [chemical binding]; other site 693746000880 catalytic site [active] 693746000881 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 693746000882 substrate binding site [chemical binding]; other site 693746000883 dimer interface [polypeptide binding]; other site 693746000884 catalytic triad [active] 693746000885 phosphoglyceromutase; Provisional; Region: PRK05434 693746000886 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693746000887 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746000888 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693746000889 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693746000890 active site 693746000891 nucleophile elbow; other site 693746000892 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_4; cd13144 693746000893 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746000894 peptide chain release factor 2; Validated; Region: prfB; PRK00578 693746000895 This domain is found in peptide chain release factors; Region: PCRF; smart00937 693746000896 RF-1 domain; Region: RF-1; pfam00472 693746000897 RNHCP domain; Region: RNHCP; pfam12647 693746000898 potential frameshift: common BLAST hit: gi|317057517|ref|YP_004105984.1| transposase IS116/IS110/IS902 family protein 693746000899 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746000900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746000901 potential frameshift: common BLAST hit: gi|317057517|ref|YP_004105984.1| transposase IS116/IS110/IS902 family protein 693746000902 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746000903 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746000904 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746000905 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 693746000906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746000907 motif II; other site 693746000908 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 693746000909 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693746000910 catalytic triad [active] 693746000911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746000912 Integrase core domain; Region: rve; pfam00665 693746000913 Integrase core domain; Region: rve_3; cl15866 693746000914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746000915 active site 693746000916 potential frameshift: common BLAST hit: gi|284047880|ref|YP_003398219.1| Nitrilase/cyanide hydratase and apolipoprotein N- acyltransferase 693746000917 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 693746000918 active site 693746000919 catalytic triad [active] 693746000920 dimer interface [polypeptide binding]; other site 693746000921 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 693746000922 EamA-like transporter family; Region: EamA; pfam00892 693746000923 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693746000924 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 693746000925 GGGtGRT protein; Region: GGGtGRT; pfam14057 693746000926 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 693746000927 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000928 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746000929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000930 active site 693746000931 DNA binding site [nucleotide binding] 693746000932 Int/Topo IB signature motif; other site 693746000933 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746000934 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746000935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746000936 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746000937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746000938 Integrase core domain; Region: rve; pfam00665 693746000939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746000940 transposase/IS protein; Provisional; Region: PRK09183 693746000941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746000942 Walker A motif; other site 693746000943 ATP binding site [chemical binding]; other site 693746000944 Walker B motif; other site 693746000945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 693746000946 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746000947 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746000948 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746000949 HTH-like domain; Region: HTH_21; pfam13276 693746000950 putative transposase OrfB; Reviewed; Region: PHA02517 693746000951 Transposase; Region: HTH_Tnp_1; pfam01527 693746000952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746000953 HTH-like domain; Region: HTH_21; pfam13276 693746000954 Integrase core domain; Region: rve; pfam00665 693746000955 Integrase core domain; Region: rve_3; pfam13683 693746000956 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 693746000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746000958 S-adenosylmethionine binding site [chemical binding]; other site 693746000959 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693746000960 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693746000961 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 693746000962 homodimer interface [polypeptide binding]; other site 693746000963 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 693746000964 active site 693746000965 TDP-binding site; other site 693746000966 acceptor substrate-binding pocket; other site 693746000967 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693746000968 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000969 active site 693746000970 DNA binding site [nucleotide binding] 693746000971 Int/Topo IB signature motif; other site 693746000972 Transposase; Region: HTH_Tnp_1; pfam01527 693746000973 HTH-like domain; Region: HTH_21; pfam13276 693746000974 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746000975 Integrase core domain; Region: rve; pfam00665 693746000976 Integrase core domain; Region: rve_3; pfam13683 693746000977 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000978 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746000979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746000980 active site 693746000981 phosphorylation site [posttranslational modification] 693746000982 intermolecular recognition site; other site 693746000983 dimerization interface [polypeptide binding]; other site 693746000984 LytTr DNA-binding domain; Region: LytTR; smart00850 693746000985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746000986 ATP binding site [chemical binding]; other site 693746000987 Mg2+ binding site [ion binding]; other site 693746000988 G-X-G motif; other site 693746000989 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 693746000990 Subtilase family; Region: Peptidase_S8; pfam00082 693746000991 active site 693746000992 catalytic residues [active] 693746000993 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746000994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746000995 active site 693746000996 DNA binding site [nucleotide binding] 693746000997 Int/Topo IB signature motif; other site 693746000998 potential frameshift: common BLAST hit: gi|295697301|ref|YP_003590539.1| putative transposase 693746000999 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746001000 Putative transposase; Region: Y2_Tnp; pfam04986 693746001001 Peptidase family S41; Region: Peptidase_S41; pfam03572 693746001002 Paired Box domain; Region: PAX; cl19075 693746001003 Transposase domain (DUF772); Region: DUF772; pfam05598 693746001004 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001005 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746001006 DctM-like transporters; Region: DctM; pfam06808 693746001007 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746001008 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 693746001009 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693746001010 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693746001011 Bacterial transcriptional regulator; Region: IclR; pfam01614 693746001012 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693746001013 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746001014 dimer interface [polypeptide binding]; other site 693746001015 PYR/PP interface [polypeptide binding]; other site 693746001016 TPP binding site [chemical binding]; other site 693746001017 substrate binding site [chemical binding]; other site 693746001018 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693746001019 Domain of unknown function; Region: EKR; smart00890 693746001020 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746001021 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 693746001022 TPP-binding site [chemical binding]; other site 693746001023 dimer interface [polypeptide binding]; other site 693746001024 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693746001025 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 693746001026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693746001027 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693746001028 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746001029 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693746001030 FAD binding site [chemical binding]; other site 693746001031 homotetramer interface [polypeptide binding]; other site 693746001032 substrate binding pocket [chemical binding]; other site 693746001033 catalytic base [active] 693746001034 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693746001035 Ligand binding site [chemical binding]; other site 693746001036 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693746001037 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693746001038 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693746001039 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 693746001040 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693746001041 ligand binding site [chemical binding]; other site 693746001042 NAD binding site [chemical binding]; other site 693746001043 catalytic site [active] 693746001044 Dehydratase family; Region: ILVD_EDD; pfam00920 693746001045 Transposase domain (DUF772); Region: DUF772; pfam05598 693746001046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746001047 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746001049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746001050 non-specific DNA binding site [nucleotide binding]; other site 693746001051 salt bridge; other site 693746001052 sequence-specific DNA binding site [nucleotide binding]; other site 693746001053 potential frameshift: common BLAST hit: gi|317057517|ref|YP_004105984.1| transposase IS116/IS110/IS902 family protein 693746001054 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746001055 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693746001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746001057 sequence-specific DNA binding site [nucleotide binding]; other site 693746001058 salt bridge; other site 693746001059 Cupin domain; Region: Cupin_2; cl17218 693746001060 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693746001061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693746001062 DNA-binding site [nucleotide binding]; DNA binding site 693746001063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746001064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746001065 homodimer interface [polypeptide binding]; other site 693746001066 catalytic residue [active] 693746001067 potential frameshift: common BLAST hit: gi|150018386|ref|YP_001310640.1| transposase IS116/IS110/IS902 family protein 693746001068 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746001069 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746001070 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746001071 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693746001072 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746001073 Walker A/P-loop; other site 693746001074 ATP binding site [chemical binding]; other site 693746001075 Q-loop/lid; other site 693746001076 ABC transporter signature motif; other site 693746001077 Walker B; other site 693746001078 D-loop; other site 693746001079 H-loop/switch region; other site 693746001080 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746001081 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693746001082 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 693746001083 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 693746001084 NADP binding site [chemical binding]; other site 693746001085 dimer interface [polypeptide binding]; other site 693746001086 YibE/F-like protein; Region: YibE_F; cl02259 693746001087 YibE/F-like protein; Region: YibE_F; cl02259 693746001088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693746001089 active site 693746001090 metal binding site [ion binding]; metal-binding site 693746001091 S-layer homology domain; Region: SLH; pfam00395 693746001092 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693746001093 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693746001094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746001095 metal binding site [ion binding]; metal-binding site 693746001096 active site 693746001097 I-site; other site 693746001098 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 693746001099 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693746001100 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 693746001101 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746001102 dimer interface [polypeptide binding]; other site 693746001103 putative CheW interface [polypeptide binding]; other site 693746001104 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 693746001105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746001106 conserved gate region; other site 693746001107 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 693746001108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746001109 dimer interface [polypeptide binding]; other site 693746001110 conserved gate region; other site 693746001111 putative PBP binding loops; other site 693746001112 ABC-ATPase subunit interface; other site 693746001113 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746001114 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746001115 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 693746001116 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746001117 active site 693746001118 motif I; other site 693746001119 motif II; other site 693746001120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 693746001121 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746001122 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001123 S-layer homology domain; Region: SLH; pfam00395 693746001124 S-layer homology domain; Region: SLH; pfam00395 693746001125 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693746001126 active site 693746001127 Int/Topo IB signature motif; other site 693746001128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746001129 Transposase; Region: HTH_Tnp_1; cl17663 693746001130 Integrase core domain; Region: rve; pfam00665 693746001131 Integrase core domain; Region: rve_3; cl15866 693746001132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746001133 FtsX-like permease family; Region: FtsX; pfam02687 693746001134 FtsX-like permease family; Region: FtsX; pfam02687 693746001135 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746001136 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746001137 Walker A/P-loop; other site 693746001138 ATP binding site [chemical binding]; other site 693746001139 Q-loop/lid; other site 693746001140 ABC transporter signature motif; other site 693746001141 Walker B; other site 693746001142 D-loop; other site 693746001143 H-loop/switch region; other site 693746001144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746001145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746001146 phosphorylation site [posttranslational modification] 693746001147 dimer interface [polypeptide binding]; other site 693746001148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746001149 ATP binding site [chemical binding]; other site 693746001150 Mg2+ binding site [ion binding]; other site 693746001151 G-X-G motif; other site 693746001152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746001153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746001154 active site 693746001155 phosphorylation site [posttranslational modification] 693746001156 intermolecular recognition site; other site 693746001157 dimerization interface [polypeptide binding]; other site 693746001158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746001159 DNA binding site [nucleotide binding] 693746001160 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746001161 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746001162 Integrase core domain; Region: rve; pfam00665 693746001163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746001164 Transposase; Region: HTH_Tnp_1; cl17663 693746001165 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746001166 HTH-like domain; Region: HTH_21; pfam13276 693746001167 Integrase core domain; Region: rve; pfam00665 693746001168 Integrase core domain; Region: rve_3; cl15866 693746001169 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 693746001170 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 693746001171 Accessory gene regulator B; Region: AgrB; cl01873 693746001172 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746001173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746001174 active site 693746001175 phosphorylation site [posttranslational modification] 693746001176 intermolecular recognition site; other site 693746001177 dimerization interface [polypeptide binding]; other site 693746001178 LytTr DNA-binding domain; Region: LytTR; pfam04397 693746001179 GHKL domain; Region: HATPase_c_5; pfam14501 693746001180 Staphylococcal AgrD protein; Region: AgrD; cl05477 693746001181 Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647 693746001182 Transposase; Region: HTH_Tnp_1; pfam01527 693746001183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746001184 HTH-like domain; Region: HTH_21; pfam13276 693746001185 Integrase core domain; Region: rve; pfam00665 693746001186 Integrase core domain; Region: rve_3; pfam13683 693746001187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 693746001188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 693746001189 potential frameshift: common BLAST hit: gi|89895586|ref|YP_519073.1| transposase 693746001190 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746001191 potential frameshift: common BLAST hit: gi|89895586|ref|YP_519073.1| transposase 693746001192 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746001193 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746001194 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746001195 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746001196 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746001197 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746001198 GMP synthase; Reviewed; Region: guaA; PRK00074 693746001199 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 693746001200 AMP/PPi binding site [chemical binding]; other site 693746001201 candidate oxyanion hole; other site 693746001202 catalytic triad [active] 693746001203 potential glutamine specificity residues [chemical binding]; other site 693746001204 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 693746001205 ATP Binding subdomain [chemical binding]; other site 693746001206 Ligand Binding sites [chemical binding]; other site 693746001207 Dimerization subdomain; other site 693746001208 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746001209 active site 693746001210 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 693746001211 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693746001212 AAA domain; Region: AAA_23; pfam13476 693746001213 integrase; Provisional; Region: int; PHA02601 693746001214 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746001215 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746001216 active site 693746001217 DNA binding site [nucleotide binding] 693746001218 Int/Topo IB signature motif; other site 693746001219 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746001220 Integrase core domain; Region: rve; pfam00665 693746001221 Integrase core domain; Region: rve_3; cl15866 693746001222 HTH-like domain; Region: HTH_21; pfam13276 693746001223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746001224 Transposase; Region: HTH_Tnp_1; cl17663 693746001225 Fic family protein [Function unknown]; Region: COG3177 693746001226 Fic/DOC family; Region: Fic; pfam02661 693746001227 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746001228 Helix-turn-helix domain; Region: HTH_17; cl17695 693746001229 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 693746001230 putative tRNA-binding site [nucleotide binding]; other site 693746001231 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746001232 PAS domain; Region: PAS_9; pfam13426 693746001233 putative active site [active] 693746001234 heme pocket [chemical binding]; other site 693746001235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746001236 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746001237 Walker A motif; other site 693746001238 ATP binding site [chemical binding]; other site 693746001239 Walker B motif; other site 693746001240 arginine finger; other site 693746001241 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693746001242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693746001243 classical (c) SDRs; Region: SDR_c; cd05233 693746001244 NAD(P) binding site [chemical binding]; other site 693746001245 active site 693746001246 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 693746001247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746001248 catalytic residue [active] 693746001249 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746001250 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746001251 catalytic residue [active] 693746001252 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 693746001253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693746001254 classical (c) SDRs; Region: SDR_c; cd05233 693746001255 NAD(P) binding site [chemical binding]; other site 693746001256 active site 693746001257 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693746001258 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 693746001259 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693746001260 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 693746001261 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 693746001262 active site 693746001263 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693746001264 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746001265 DNA binding residues [nucleotide binding] 693746001266 threonine dehydratase; Provisional; Region: PRK08198 693746001267 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693746001268 tetramer interface [polypeptide binding]; other site 693746001269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746001270 catalytic residue [active] 693746001271 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 693746001272 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693746001273 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693746001274 homotrimer interaction site [polypeptide binding]; other site 693746001275 putative active site [active] 693746001276 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 693746001277 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 693746001278 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693746001279 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 693746001280 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746001281 dimer interface [polypeptide binding]; other site 693746001282 PYR/PP interface [polypeptide binding]; other site 693746001283 TPP binding site [chemical binding]; other site 693746001284 substrate binding site [chemical binding]; other site 693746001285 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 693746001286 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 693746001287 TPP-binding site [chemical binding]; other site 693746001288 putative dimer interface [polypeptide binding]; other site 693746001289 Transposase domain (DUF772); Region: DUF772; pfam05598 693746001290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746001291 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001292 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746001293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746001294 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746001295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746001296 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693746001297 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746001298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746001299 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746001300 transposase/IS protein; Provisional; Region: PRK09183 693746001301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746001302 Walker A motif; other site 693746001303 ATP binding site [chemical binding]; other site 693746001304 Walker B motif; other site 693746001305 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746001306 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746001307 Integrase core domain; Region: rve; pfam00665 693746001308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746001309 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 693746001310 Uncharacterized conserved protein [Function unknown]; Region: RtcB; cl17455 693746001311 Uncharacterized prokaryotic subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_eoslipins_u2; cd13438 693746001312 prohibitin homologues; Region: PHB; smart00244 693746001313 WYL domain; Region: WYL; pfam13280 693746001314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746001315 putative DNA binding site [nucleotide binding]; other site 693746001316 putative Zn2+ binding site [ion binding]; other site 693746001317 WYL domain; Region: WYL; pfam13280 693746001318 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746001319 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 693746001320 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693746001321 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693746001322 active site 693746001323 DNA binding site [nucleotide binding] 693746001324 TfoX N-terminal domain; Region: TfoX_N; cl17592 693746001325 YoaP-like; Region: YoaP; pfam14268 693746001326 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 693746001327 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 693746001328 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693746001329 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746001330 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746001331 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 693746001332 Na binding site [ion binding]; other site 693746001333 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 693746001334 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 693746001335 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693746001336 putative trimer interface [polypeptide binding]; other site 693746001337 putative CoA binding site [chemical binding]; other site 693746001338 dihydrodipicolinate reductase; Provisional; Region: PRK00048 693746001339 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 693746001340 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 693746001341 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 693746001342 dimer interface [polypeptide binding]; other site 693746001343 active site 693746001344 catalytic residue [active] 693746001345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746001346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746001347 active site 693746001348 phosphorylation site [posttranslational modification] 693746001349 intermolecular recognition site; other site 693746001350 dimerization interface [polypeptide binding]; other site 693746001351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746001352 DNA binding site [nucleotide binding] 693746001353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746001354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746001355 ATP binding site [chemical binding]; other site 693746001356 Mg2+ binding site [ion binding]; other site 693746001357 G-X-G motif; other site 693746001358 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746001359 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746001360 Walker A/P-loop; other site 693746001361 ATP binding site [chemical binding]; other site 693746001362 Q-loop/lid; other site 693746001363 ABC transporter signature motif; other site 693746001364 Walker B; other site 693746001365 D-loop; other site 693746001366 H-loop/switch region; other site 693746001367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746001368 FtsX-like permease family; Region: FtsX; pfam02687 693746001369 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746001370 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746001371 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746001372 phosphodiesterase; Provisional; Region: PRK12704 693746001373 AAA domain; Region: AAA_23; pfam13476 693746001374 KH domain; Region: KH_1; pfam00013 693746001375 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746001376 Zn2+ binding site [ion binding]; other site 693746001377 Mg2+ binding site [ion binding]; other site 693746001378 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693746001379 active site 693746001380 metal binding site [ion binding]; metal-binding site 693746001381 Bacterial SH3 domain; Region: SH3_3; pfam08239 693746001382 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 693746001383 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 693746001384 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 693746001385 putative RNA binding site [nucleotide binding]; other site 693746001386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746001387 S-adenosylmethionine binding site [chemical binding]; other site 693746001388 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 693746001389 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 693746001390 putative dimer interface [polypeptide binding]; other site 693746001391 putative anticodon binding site; other site 693746001392 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 693746001393 homodimer interface [polypeptide binding]; other site 693746001394 motif 1; other site 693746001395 motif 2; other site 693746001396 active site 693746001397 motif 3; other site 693746001398 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746001399 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746001400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 693746001401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746001402 NAD(P) binding site [chemical binding]; other site 693746001403 active site 693746001404 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693746001405 inhibitor-cofactor binding pocket; inhibition site 693746001406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746001407 catalytic residue [active] 693746001408 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 693746001409 trimer interface [polypeptide binding]; other site 693746001410 active site 693746001411 substrate binding site [chemical binding]; other site 693746001412 CoA binding site [chemical binding]; other site 693746001413 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 693746001414 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 693746001415 putative metal binding site; other site 693746001416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693746001417 binding surface 693746001418 TPR motif; other site 693746001419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 693746001420 TPR repeat; Region: TPR_11; pfam13414 693746001421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746001422 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746001423 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 693746001424 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 693746001425 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 693746001426 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 693746001427 putative trimer interface [polypeptide binding]; other site 693746001428 putative active site [active] 693746001429 putative substrate binding site [chemical binding]; other site 693746001430 putative CoA binding site [chemical binding]; other site 693746001431 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 693746001432 inhibitor-cofactor binding pocket; inhibition site 693746001433 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746001434 catalytic residue [active] 693746001435 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 693746001436 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 693746001437 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693746001438 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 693746001439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746001440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746001441 WHG domain; Region: WHG; pfam13305 693746001442 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693746001443 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693746001444 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693746001445 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693746001446 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 693746001447 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 693746001448 flagellin; Reviewed; Region: PRK08869 693746001449 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 693746001450 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 693746001451 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 693746001452 Walker A/P-loop; other site 693746001453 ATP binding site [chemical binding]; other site 693746001454 Q-loop/lid; other site 693746001455 ABC transporter signature motif; other site 693746001456 Walker B; other site 693746001457 D-loop; other site 693746001458 H-loop/switch region; other site 693746001459 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693746001460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746001461 dimer interface [polypeptide binding]; other site 693746001462 conserved gate region; other site 693746001463 putative PBP binding loops; other site 693746001464 ABC-ATPase subunit interface; other site 693746001465 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693746001466 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746001467 RES domain; Region: RES; smart00953 693746001468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746001469 Walker A/P-loop; other site 693746001470 ATP binding site [chemical binding]; other site 693746001471 AAA domain; Region: AAA_30; pfam13604 693746001472 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 693746001473 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693746001474 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 693746001475 FIC domain binding interface [polypeptide binding]; other site 693746001476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746001477 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746001478 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746001479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746001480 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746001481 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746001482 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746001483 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 693746001484 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 693746001485 AAA domain; Region: AAA_14; pfam13173 693746001486 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 693746001487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746001488 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746001489 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693746001490 catalytic residues [active] 693746001491 catalytic nucleophile [active] 693746001492 Presynaptic Site I dimer interface [polypeptide binding]; other site 693746001493 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693746001494 Synaptic Flat tetramer interface [polypeptide binding]; other site 693746001495 Synaptic Site I dimer interface [polypeptide binding]; other site 693746001496 DNA binding site [nucleotide binding] 693746001497 Recombinase; Region: Recombinase; pfam07508 693746001498 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746001499 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693746001500 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693746001501 Lamin Tail Domain; Region: LTD; pfam00932 693746001502 EAL domain; Region: EAL; pfam00563 693746001503 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693746001504 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 693746001505 Cell division protein FtsA; Region: FtsA; smart00842 693746001506 Cell division protein FtsA; Region: FtsA; pfam14450 693746001507 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 693746001508 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693746001509 HAMP domain; Region: HAMP; pfam00672 693746001510 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746001511 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746001512 dimer interface [polypeptide binding]; other site 693746001513 putative CheW interface [polypeptide binding]; other site 693746001514 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693746001515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746001516 Walker A/P-loop; other site 693746001517 ATP binding site [chemical binding]; other site 693746001518 Q-loop/lid; other site 693746001519 ABC transporter signature motif; other site 693746001520 Walker B; other site 693746001521 D-loop; other site 693746001522 H-loop/switch region; other site 693746001523 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 693746001524 putative active site [active] 693746001525 Flagellar protein FliS; Region: FliS; cl00654 693746001526 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 693746001527 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 693746001528 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746001529 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746001530 P-loop; other site 693746001531 Magnesium ion binding site [ion binding]; other site 693746001532 Late competence development protein ComFB; Region: ComFB; pfam10719 693746001533 potential frameshift: common BLAST hit: gi|160880549|ref|YP_001559517.1| GCN5-related N-acetyltransferase 693746001534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746001535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746001536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746001537 Coenzyme A binding pocket [chemical binding]; other site 693746001538 Transposase domain (DUF772); Region: DUF772; pfam05598 693746001539 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746001540 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001541 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 693746001542 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 693746001543 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693746001544 putative transposase OrfB; Reviewed; Region: PHA02517 693746001545 HTH-like domain; Region: HTH_21; pfam13276 693746001546 Integrase core domain; Region: rve_2; pfam13333 693746001547 Domain of unknown function (DUF1875); Region: DUF1875; pfam08961 693746001548 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 693746001549 Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]; Region: COG5124 693746001550 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746001551 YibE/F-like protein; Region: YibE_F; pfam07907 693746001552 YibE/F-like protein; Region: YibE_F; pfam07907 693746001553 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 693746001554 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693746001555 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693746001556 Hemerythrin; Region: Hemerythrin; cd12107 693746001557 Fe binding site [ion binding]; other site 693746001558 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 693746001559 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 693746001560 Hemerythrin; Region: Hemerythrin; cd12107 693746001561 Fe binding site [ion binding]; other site 693746001562 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 693746001563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693746001564 DNA binding residues [nucleotide binding] 693746001565 dimerization interface [polypeptide binding]; other site 693746001566 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693746001567 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693746001568 active site 693746001569 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 693746001570 dimer interface [polypeptide binding]; other site 693746001571 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693746001572 Ligand Binding Site [chemical binding]; other site 693746001573 Molecular Tunnel; other site 693746001574 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746001575 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693746001576 trimerization site [polypeptide binding]; other site 693746001577 active site 693746001578 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746001579 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746001580 catalytic residue [active] 693746001581 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 693746001582 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 693746001583 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 693746001584 active site 693746001585 catalytic motif [active] 693746001586 Zn binding site [ion binding]; other site 693746001587 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746001588 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746001589 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 693746001590 MgtE intracellular N domain; Region: MgtE_N; smart00924 693746001591 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 693746001592 Divalent cation transporter; Region: MgtE; pfam01769 693746001593 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693746001594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746001595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746001596 DNA binding residues [nucleotide binding] 693746001597 hypothetical protein; Reviewed; Region: PRK00024 693746001598 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 693746001599 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 693746001600 MPN+ (JAMM) motif; other site 693746001601 Zinc-binding site [ion binding]; other site 693746001602 excinuclease ABC subunit B; Provisional; Region: PRK05298 693746001603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746001604 ATP binding site [chemical binding]; other site 693746001605 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746001606 nucleotide binding region [chemical binding]; other site 693746001607 ATP-binding site [chemical binding]; other site 693746001608 Ultra-violet resistance protein B; Region: UvrB; pfam12344 693746001609 UvrB/uvrC motif; Region: UVR; pfam02151 693746001610 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 693746001611 DHHW protein; Region: DHHW; pfam14286 693746001612 EamA-like transporter family; Region: EamA; pfam00892 693746001613 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693746001614 EamA-like transporter family; Region: EamA; pfam00892 693746001615 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 693746001616 putative deacylase active site [active] 693746001617 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 693746001618 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 693746001619 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693746001620 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693746001621 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 693746001622 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 693746001623 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693746001624 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693746001625 Walker A/P-loop; other site 693746001626 ATP binding site [chemical binding]; other site 693746001627 Q-loop/lid; other site 693746001628 ABC transporter signature motif; other site 693746001629 Walker B; other site 693746001630 D-loop; other site 693746001631 H-loop/switch region; other site 693746001632 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 693746001633 dinuclear metal binding motif [ion binding]; other site 693746001634 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 693746001635 Phosphotransferase enzyme family; Region: APH; pfam01636 693746001636 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 693746001637 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 693746001638 intersubunit interface [polypeptide binding]; other site 693746001639 active site 693746001640 Zn2+ binding site [ion binding]; other site 693746001641 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 693746001642 substrate binding site [chemical binding]; other site 693746001643 hexamer interface [polypeptide binding]; other site 693746001644 metal binding site [ion binding]; metal-binding site 693746001645 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693746001646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746001647 catalytic residue [active] 693746001648 recombination protein RecR; Reviewed; Region: recR; PRK00076 693746001649 RecR protein; Region: RecR; pfam02132 693746001650 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 693746001651 putative active site [active] 693746001652 putative metal-binding site [ion binding]; other site 693746001653 tetramer interface [polypeptide binding]; other site 693746001654 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 693746001655 GTPase Era; Reviewed; Region: era; PRK00089 693746001656 G1 box; other site 693746001657 GTP/Mg2+ binding site [chemical binding]; other site 693746001658 Switch I region; other site 693746001659 G2 box; other site 693746001660 Switch II region; other site 693746001661 G3 box; other site 693746001662 G4 box; other site 693746001663 G5 box; other site 693746001664 KH domain; Region: KH_2; pfam07650 693746001665 G-X-X-G motif; other site 693746001666 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 693746001667 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693746001668 trimer interface [polypeptide binding]; other site 693746001669 active site 693746001670 substrate binding site [chemical binding]; other site 693746001671 CoA binding site [chemical binding]; other site 693746001672 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 693746001673 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 693746001674 active site 693746001675 HIGH motif; other site 693746001676 KMSKS motif; other site 693746001677 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 693746001678 tRNA binding surface [nucleotide binding]; other site 693746001679 anticodon binding site; other site 693746001680 Transposase domain (DUF772); Region: DUF772; pfam05598 693746001681 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746001683 dimerization interface [polypeptide binding]; other site 693746001684 putative DNA binding site [nucleotide binding]; other site 693746001685 putative Zn2+ binding site [ion binding]; other site 693746001686 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746001687 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 693746001688 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 693746001689 catalytic residues [active] 693746001690 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 693746001691 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 693746001692 active site 693746001693 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 693746001694 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 693746001695 dimerization interface [polypeptide binding]; other site 693746001696 ATP binding site [chemical binding]; other site 693746001697 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 693746001698 dimerization interface [polypeptide binding]; other site 693746001699 ATP binding site [chemical binding]; other site 693746001700 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 693746001701 conserved cys residue [active] 693746001702 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 693746001703 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 693746001704 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 693746001705 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 693746001706 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 693746001707 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 693746001708 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 693746001709 active site 693746001710 substrate binding site [chemical binding]; other site 693746001711 cosubstrate binding site; other site 693746001712 catalytic site [active] 693746001713 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 693746001714 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 693746001715 dimerization interface [polypeptide binding]; other site 693746001716 putative ATP binding site [chemical binding]; other site 693746001717 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 693746001718 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 693746001719 active site 693746001720 tetramer interface [polypeptide binding]; other site 693746001721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746001722 active site 693746001723 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 693746001724 ATP binding site [chemical binding]; other site 693746001725 active site 693746001726 substrate binding site [chemical binding]; other site 693746001727 AIR carboxylase; Region: AIRC; pfam00731 693746001728 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693746001729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693746001730 DNA-binding site [nucleotide binding]; DNA binding site 693746001731 UTRA domain; Region: UTRA; pfam07702 693746001732 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 693746001733 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693746001734 ADP binding site [chemical binding]; other site 693746001735 magnesium binding site [ion binding]; other site 693746001736 putative shikimate binding site; other site 693746001737 transcription elongation factor GreA; Region: greA; TIGR01462 693746001738 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693746001739 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693746001740 EamA-like transporter family; Region: EamA; pfam00892 693746001741 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693746001742 EamA-like transporter family; Region: EamA; pfam00892 693746001743 aspartate carbamoyltransferase, regulatory subunit; Region: ATCase_reg; TIGR00240 693746001744 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 693746001745 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 693746001746 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 693746001747 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693746001748 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693746001749 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746001750 active site 693746001751 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 693746001752 active site 693746001753 dimer interface [polypeptide binding]; other site 693746001754 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 693746001755 heterodimer interface [polypeptide binding]; other site 693746001756 active site 693746001757 FMN binding site [chemical binding]; other site 693746001758 homodimer interface [polypeptide binding]; other site 693746001759 substrate binding site [chemical binding]; other site 693746001760 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 693746001761 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 693746001762 FAD binding pocket [chemical binding]; other site 693746001763 FAD binding motif [chemical binding]; other site 693746001764 phosphate binding motif [ion binding]; other site 693746001765 beta-alpha-beta structure motif; other site 693746001766 NAD binding pocket [chemical binding]; other site 693746001767 Iron coordination center [ion binding]; other site 693746001768 dihydroorotase; Validated; Region: pyrC; PRK09357 693746001769 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746001770 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 693746001771 active site 693746001772 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 693746001773 Cation transport protein; Region: TrkH; cl17365 693746001774 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 693746001775 TrkA-N domain; Region: TrkA_N; pfam02254 693746001776 TrkA-C domain; Region: TrkA_C; pfam02080 693746001777 TrkA-N domain; Region: TrkA_N; pfam02254 693746001778 TrkA-C domain; Region: TrkA_C; pfam02080 693746001779 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 693746001780 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 693746001781 G1 box; other site 693746001782 GTP/Mg2+ binding site [chemical binding]; other site 693746001783 G2 box; other site 693746001784 Switch I region; other site 693746001785 G3 box; other site 693746001786 Switch II region; other site 693746001787 G4 box; other site 693746001788 G5 box; other site 693746001789 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 693746001790 Elongation Factor G, domain II; Region: EFG_II; pfam14492 693746001791 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 693746001792 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 693746001793 YacP-like NYN domain; Region: NYN_YacP; pfam05991 693746001794 Recombination protein O N terminal; Region: RecO_N; pfam11967 693746001795 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 693746001796 Recombination protein O C terminal; Region: RecO_C; pfam02565 693746001797 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 693746001798 MutS domain III; Region: MutS_III; pfam05192 693746001799 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 693746001800 Walker A/P-loop; other site 693746001801 ATP binding site [chemical binding]; other site 693746001802 Q-loop/lid; other site 693746001803 ABC transporter signature motif; other site 693746001804 Walker B; other site 693746001805 D-loop; other site 693746001806 H-loop/switch region; other site 693746001807 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693746001808 Smr domain; Region: Smr; pfam01713 693746001809 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 693746001810 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 693746001811 Conserved TM helix; Region: TM_helix; pfam05552 693746001812 Mechanosensitive ion channel; Region: MS_channel; pfam00924 693746001813 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 693746001814 putative active site [active] 693746001815 catalytic triad [active] 693746001816 dimer interface [polypeptide binding]; other site 693746001817 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693746001818 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 693746001819 NAD binding site [chemical binding]; other site 693746001820 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 693746001821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746001822 Walker A motif; other site 693746001823 ATP binding site [chemical binding]; other site 693746001824 Walker B motif; other site 693746001825 arginine finger; other site 693746001826 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 693746001827 Protein of unknown function (DUF1312); Region: DUF1312; pfam07009 693746001828 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693746001829 HTH-like domain; Region: HTH_21; pfam13276 693746001830 Integrase core domain; Region: rve; pfam00665 693746001831 Integrase core domain; Region: rve_2; pfam13333 693746001832 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 693746001833 hypothetical protein; Validated; Region: PRK00153 693746001834 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 693746001835 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 693746001836 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693746001837 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 693746001838 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693746001839 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 693746001840 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 693746001841 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693746001842 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693746001843 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746001844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746001845 glycerol kinase; Provisional; Region: glpK; PRK00047 693746001846 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693746001847 N- and C-terminal domain interface [polypeptide binding]; other site 693746001848 active site 693746001849 MgATP binding site [chemical binding]; other site 693746001850 catalytic site [active] 693746001851 metal binding site [ion binding]; metal-binding site 693746001852 glycerol binding site [chemical binding]; other site 693746001853 homotetramer interface [polypeptide binding]; other site 693746001854 homodimer interface [polypeptide binding]; other site 693746001855 FBP binding site [chemical binding]; other site 693746001856 protein IIAGlc interface [polypeptide binding]; other site 693746001857 glycerol kinase; Provisional; Region: glpK; PRK00047 693746001858 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693746001859 N- and C-terminal domain interface [polypeptide binding]; other site 693746001860 active site 693746001861 MgATP binding site [chemical binding]; other site 693746001862 catalytic site [active] 693746001863 metal binding site [ion binding]; metal-binding site 693746001864 glycerol binding site [chemical binding]; other site 693746001865 homotetramer interface [polypeptide binding]; other site 693746001866 homodimer interface [polypeptide binding]; other site 693746001867 FBP binding site [chemical binding]; other site 693746001868 protein IIAGlc interface [polypeptide binding]; other site 693746001869 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 693746001870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746001871 catalytic residue [active] 693746001872 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746001873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746001874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746001875 Helix-turn-helix domain; Region: HTH_18; pfam12833 693746001876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746001877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746001878 dimerization interface [polypeptide binding]; other site 693746001879 putative DNA binding site [nucleotide binding]; other site 693746001880 putative Zn2+ binding site [ion binding]; other site 693746001881 Predicted permeases [General function prediction only]; Region: COG0701 693746001882 Ferredoxin [Energy production and conversion]; Region: COG1146 693746001883 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746001884 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 693746001885 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 693746001886 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 693746001887 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693746001888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746001889 Coenzyme A binding pocket [chemical binding]; other site 693746001890 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 693746001891 active site 693746001892 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 693746001893 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 693746001894 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 693746001895 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 693746001896 NiFe/NiFeSe hydrogenase small subunit C-terminal; Region: NiFe_hyd_SSU_C; pfam14720 693746001897 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 693746001898 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 693746001899 nickel binding site [ion binding]; other site 693746001900 Acylphosphatase; Region: Acylphosphatase; pfam00708 693746001901 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 693746001902 HypF finger; Region: zf-HYPF; pfam07503 693746001903 HypF finger; Region: zf-HYPF; pfam07503 693746001904 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 693746001905 HupF/HypC family; Region: HupF_HypC; pfam01455 693746001906 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 693746001907 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 693746001908 dimerization interface [polypeptide binding]; other site 693746001909 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 693746001910 ATP binding site [chemical binding]; other site 693746001911 FtsX-like permease family; Region: FtsX; pfam02687 693746001912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746001913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746001914 Walker A/P-loop; other site 693746001915 ATP binding site [chemical binding]; other site 693746001916 Q-loop/lid; other site 693746001917 ABC transporter signature motif; other site 693746001918 Walker B; other site 693746001919 D-loop; other site 693746001920 H-loop/switch region; other site 693746001921 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746001922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746001923 active site 693746001924 phosphorylation site [posttranslational modification] 693746001925 intermolecular recognition site; other site 693746001926 dimerization interface [polypeptide binding]; other site 693746001927 LytTr DNA-binding domain; Region: LytTR; smart00850 693746001928 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 693746001929 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 693746001930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746001931 ATP binding site [chemical binding]; other site 693746001932 Mg2+ binding site [ion binding]; other site 693746001933 G-X-G motif; other site 693746001934 potential frameshift: common BLAST hit: gi|337737972|ref|YP_004637419.1| polyferredoxin 693746001935 FMN-binding domain; Region: FMN_bind; cl01081 693746001936 FMN-binding domain; Region: FMN_bind; cl01081 693746001937 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693746001938 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 693746001939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746001940 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746001941 dimerization interface [polypeptide binding]; other site 693746001942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746001943 dimer interface [polypeptide binding]; other site 693746001944 phosphorylation site [posttranslational modification] 693746001945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746001946 ATP binding site [chemical binding]; other site 693746001947 Mg2+ binding site [ion binding]; other site 693746001948 G-X-G motif; other site 693746001949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746001951 active site 693746001952 phosphorylation site [posttranslational modification] 693746001953 intermolecular recognition site; other site 693746001954 dimerization interface [polypeptide binding]; other site 693746001955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746001956 DNA binding site [nucleotide binding] 693746001957 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746001958 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693746001959 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746001960 Int/Topo IB signature motif; other site 693746001961 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 693746001962 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693746001963 nucleotidyl binding site; other site 693746001964 metal binding site [ion binding]; metal-binding site 693746001965 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693746001966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746001967 dimerization interface [polypeptide binding]; other site 693746001968 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746001969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746001970 dimer interface [polypeptide binding]; other site 693746001971 putative CheW interface [polypeptide binding]; other site 693746001972 Transposase domain (DUF772); Region: DUF772; pfam05598 693746001973 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746001974 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746001975 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746001976 Int/Topo IB signature motif; other site 693746001977 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693746001978 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693746001979 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746001980 Int/Topo IB signature motif; other site 693746001981 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693746001982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746001983 dimerization interface [polypeptide binding]; other site 693746001984 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746001985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746001986 dimer interface [polypeptide binding]; other site 693746001987 putative CheW interface [polypeptide binding]; other site 693746001988 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746001989 Zn2+ binding site [ion binding]; other site 693746001990 Mg2+ binding site [ion binding]; other site 693746001991 PAS domain; Region: PAS; smart00091 693746001992 PAS domain S-box; Region: sensory_box; TIGR00229 693746001993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746001994 metal binding site [ion binding]; metal-binding site 693746001995 active site 693746001996 I-site; other site 693746001997 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746001998 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693746001999 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746002000 Walker A/P-loop; other site 693746002001 ATP binding site [chemical binding]; other site 693746002002 Q-loop/lid; other site 693746002003 ABC transporter signature motif; other site 693746002004 Walker B; other site 693746002005 D-loop; other site 693746002006 H-loop/switch region; other site 693746002007 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 693746002008 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693746002009 GtrA-like protein; Region: GtrA; cl19823 693746002010 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 693746002011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746002012 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 693746002013 metal binding site [ion binding]; metal-binding site 693746002014 dimer interface [polypeptide binding]; other site 693746002015 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746002016 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 693746002017 metal binding site [ion binding]; metal-binding site 693746002018 putative dimer interface [polypeptide binding]; other site 693746002019 Protein of unknown function (DUF554); Region: DUF554; pfam04474 693746002020 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 693746002021 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746002022 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746002023 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746002024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002025 active site 693746002026 phosphorylation site [posttranslational modification] 693746002027 intermolecular recognition site; other site 693746002028 dimerization interface [polypeptide binding]; other site 693746002029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746002030 DNA binding site [nucleotide binding] 693746002031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746002032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746002033 dimer interface [polypeptide binding]; other site 693746002034 phosphorylation site [posttranslational modification] 693746002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746002036 ATP binding site [chemical binding]; other site 693746002037 Mg2+ binding site [ion binding]; other site 693746002038 G-X-G motif; other site 693746002039 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 693746002040 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 693746002041 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 693746002042 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746002043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746002044 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 693746002045 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 693746002046 active site 693746002047 dimer interface [polypeptide binding]; other site 693746002048 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 693746002049 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 693746002050 active site 693746002051 FMN binding site [chemical binding]; other site 693746002052 substrate binding site [chemical binding]; other site 693746002053 3Fe-4S cluster binding site [ion binding]; other site 693746002054 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 693746002055 domain interface; other site 693746002056 ANTAR domain; Region: ANTAR; pfam03861 693746002057 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 693746002058 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 693746002059 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693746002060 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746002061 Soluble P-type ATPase [General function prediction only]; Region: COG4087 693746002062 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 693746002063 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 693746002064 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 693746002065 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 693746002066 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 693746002067 Na binding site [ion binding]; other site 693746002068 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 693746002069 HAMP domain; Region: HAMP; pfam00672 693746002070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746002071 dimer interface [polypeptide binding]; other site 693746002072 phosphorylation site [posttranslational modification] 693746002073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746002074 ATP binding site [chemical binding]; other site 693746002075 Mg2+ binding site [ion binding]; other site 693746002076 G-X-G motif; other site 693746002077 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 693746002078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002079 active site 693746002080 phosphorylation site [posttranslational modification] 693746002081 intermolecular recognition site; other site 693746002082 dimerization interface [polypeptide binding]; other site 693746002083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746002084 Walker A motif; other site 693746002085 ATP binding site [chemical binding]; other site 693746002086 Walker B motif; other site 693746002087 arginine finger; other site 693746002088 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693746002089 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 693746002090 putative active site [active] 693746002091 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 693746002092 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 693746002093 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 693746002094 hypothetical protein; Provisional; Region: PRK05463 693746002095 Stage III sporulation protein D; Region: SpoIIID; pfam12116 693746002096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 693746002097 DNA-binding site [nucleotide binding]; DNA binding site 693746002098 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 693746002099 nucleoside/Zn binding site; other site 693746002100 dimer interface [polypeptide binding]; other site 693746002101 catalytic motif [active] 693746002102 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 693746002103 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 693746002104 23S rRNA interface [nucleotide binding]; other site 693746002105 L3 interface [polypeptide binding]; other site 693746002106 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 693746002107 HTH-like domain; Region: HTH_21; pfam13276 693746002108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746002109 Integrase core domain; Region: rve; pfam00665 693746002110 Integrase core domain; Region: rve_3; pfam13683 693746002111 Transposase; Region: HTH_Tnp_1; pfam01527 693746002112 S-layer homology domain; Region: SLH; pfam00395 693746002113 S-layer homology domain; Region: SLH; pfam00395 693746002114 Photosynthesis system II assembly factor YCF48; Region: PSII_BNR; pfam14870 693746002115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746002116 Transposase; Region: HTH_Tnp_1; cl17663 693746002117 putative transposase OrfB; Reviewed; Region: PHA02517 693746002118 Integrase core domain; Region: rve; pfam00665 693746002119 Integrase core domain; Region: rve_3; cl15866 693746002120 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746002121 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746002122 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746002123 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746002124 DNA binding residues [nucleotide binding] 693746002125 Transposase; Region: HTH_Tnp_1; pfam01527 693746002126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746002127 HTH-like domain; Region: HTH_21; pfam13276 693746002128 Integrase core domain; Region: rve; pfam00665 693746002129 Integrase core domain; Region: rve_3; pfam13683 693746002130 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746002131 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746002132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746002133 Integrase core domain; Region: rve; pfam00665 693746002134 transposase/IS protein; Provisional; Region: PRK09183 693746002135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746002136 Walker A motif; other site 693746002137 ATP binding site [chemical binding]; other site 693746002138 Walker B motif; other site 693746002139 Transposase domain (DUF772); Region: DUF772; pfam05598 693746002140 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746002141 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746002142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746002143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746002144 DNA binding residues [nucleotide binding] 693746002145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746002146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746002147 non-specific DNA binding site [nucleotide binding]; other site 693746002148 salt bridge; other site 693746002149 sequence-specific DNA binding site [nucleotide binding]; other site 693746002150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746002151 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746002152 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746002153 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746002154 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746002155 catalytic residues [active] 693746002156 catalytic nucleophile [active] 693746002157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746002158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002159 active site 693746002160 phosphorylation site [posttranslational modification] 693746002161 intermolecular recognition site; other site 693746002162 dimerization interface [polypeptide binding]; other site 693746002163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746002164 DNA binding site [nucleotide binding] 693746002165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746002166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746002167 dimer interface [polypeptide binding]; other site 693746002168 phosphorylation site [posttranslational modification] 693746002169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746002170 ATP binding site [chemical binding]; other site 693746002171 Mg2+ binding site [ion binding]; other site 693746002172 G-X-G motif; other site 693746002173 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746002174 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746002175 Walker A/P-loop; other site 693746002176 ATP binding site [chemical binding]; other site 693746002177 Q-loop/lid; other site 693746002178 ABC transporter signature motif; other site 693746002179 Walker B; other site 693746002180 D-loop; other site 693746002181 H-loop/switch region; other site 693746002182 FtsX-like permease family; Region: FtsX; pfam02687 693746002183 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746002184 FtsX-like permease family; Region: FtsX; pfam02687 693746002185 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 693746002186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746002187 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 693746002188 FMN binding site [chemical binding]; other site 693746002189 dimer interface [polypeptide binding]; other site 693746002190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746002191 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746002192 Walker A motif; other site 693746002193 ATP binding site [chemical binding]; other site 693746002194 Walker B motif; other site 693746002195 arginine finger; other site 693746002196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746002197 Integrase core domain; Region: rve; pfam00665 693746002198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746002199 HTH-like domain; Region: HTH_21; pfam13276 693746002200 Integrase core domain; Region: rve; pfam00665 693746002201 Integrase core domain; Region: rve_3; pfam13683 693746002202 Transposase; Region: HTH_Tnp_1; pfam01527 693746002203 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 693746002204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746002205 Transposase; Region: HTH_Tnp_1; cl17663 693746002206 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746002207 HTH-like domain; Region: HTH_21; pfam13276 693746002208 Integrase core domain; Region: rve; pfam00665 693746002209 Integrase core domain; Region: rve_3; cl15866 693746002210 S-layer homology domain; Region: SLH; pfam00395 693746002211 S-layer homology domain; Region: SLH; pfam00395 693746002212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746002213 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746002214 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 693746002215 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693746002216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746002217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746002218 DNA binding residues [nucleotide binding] 693746002219 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 693746002220 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 693746002221 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746002222 Integrase core domain; Region: rve; pfam00665 693746002223 Integrase core domain; Region: rve_3; cl15866 693746002224 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693746002225 NlpC/p60-like transpeptidase; Region: Transpep_BrtH; pfam14399 693746002226 putative active site [active] 693746002227 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746002228 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 693746002229 DNA binding residues [nucleotide binding] 693746002230 drug binding residues [chemical binding]; other site 693746002231 dimer interface [polypeptide binding]; other site 693746002232 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693746002233 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746002234 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746002235 active site 693746002236 DNA binding site [nucleotide binding] 693746002237 Int/Topo IB signature motif; other site 693746002238 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746002239 Putative transposase; Region: Y2_Tnp; pfam04986 693746002240 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 693746002241 classical (c) SDRs; Region: SDR_c; cd05233 693746002242 NAD(P) binding site [chemical binding]; other site 693746002243 active site 693746002244 Protein of unknown function (DUF503); Region: DUF503; pfam04456 693746002245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746002246 Transposase; Region: HTH_Tnp_1; cl17663 693746002247 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746002248 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693746002249 Integrase core domain; Region: rve; pfam00665 693746002250 Integrase core domain; Region: rve_3; cl15866 693746002251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746002252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746002253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746002254 dimerization interface [polypeptide binding]; other site 693746002255 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693746002256 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693746002257 transmembrane helices; other site 693746002258 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746002259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746002260 Transposase; Region: HTH_Tnp_1; cl17663 693746002261 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693746002262 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693746002263 putative active site [active] 693746002264 putative NTP binding site [chemical binding]; other site 693746002265 putative nucleic acid binding site [nucleotide binding]; other site 693746002266 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 693746002267 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693746002268 phosphate binding site [ion binding]; other site 693746002269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693746002270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746002271 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693746002272 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 693746002273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746002274 Transposase; Region: HTH_Tnp_1; cl17663 693746002275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746002276 Integrase core domain; Region: rve; pfam00665 693746002277 transposase/IS protein; Provisional; Region: PRK09183 693746002278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746002279 Walker A motif; other site 693746002280 ATP binding site [chemical binding]; other site 693746002281 Walker B motif; other site 693746002282 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693746002283 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 693746002284 metal binding site 2 [ion binding]; metal-binding site 693746002285 putative DNA binding helix; other site 693746002286 metal binding site 1 [ion binding]; metal-binding site 693746002287 dimer interface [polypeptide binding]; other site 693746002288 structural Zn2+ binding site [ion binding]; other site 693746002289 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 693746002290 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693746002291 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693746002292 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 693746002293 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693746002294 Probable zinc-binding domain; Region: zf-trcl; pfam13451 693746002295 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 693746002296 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 693746002297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746002298 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693746002299 putative substrate translocation pore; other site 693746002300 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746002301 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746002302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746002303 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746002304 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 693746002305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746002306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746002307 non-specific DNA binding site [nucleotide binding]; other site 693746002308 salt bridge; other site 693746002309 sequence-specific DNA binding site [nucleotide binding]; other site 693746002310 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 693746002311 potential frameshift: common BLAST hit: gi|258514764|ref|YP_003190986.1| DNA-cytosine methyltransferase 693746002312 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 693746002313 cofactor binding site; other site 693746002314 DNA binding site [nucleotide binding] 693746002315 substrate interaction site [chemical binding]; other site 693746002316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746002317 Zn2+ binding site [ion binding]; other site 693746002318 Mg2+ binding site [ion binding]; other site 693746002319 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 693746002320 cubane metal cluster [ion binding]; other site 693746002321 hybrid metal cluster; other site 693746002322 Rubredoxin [Energy production and conversion]; Region: COG1773 693746002323 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 693746002324 iron binding site [ion binding]; other site 693746002325 Cupin domain; Region: Cupin_2; cl17218 693746002326 Ferredoxin [Energy production and conversion]; Region: COG1146 693746002327 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 693746002328 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693746002329 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693746002330 ligand binding site [chemical binding]; other site 693746002331 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 693746002332 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693746002333 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693746002334 ligand binding site [chemical binding]; other site 693746002335 flexible hinge region; other site 693746002336 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693746002337 non-specific DNA interactions [nucleotide binding]; other site 693746002338 DNA binding site [nucleotide binding] 693746002339 sequence specific DNA binding site [nucleotide binding]; other site 693746002340 putative cAMP binding site [chemical binding]; other site 693746002341 Predicted permease; Region: DUF318; cl17795 693746002342 Predicted permease; Region: DUF318; cl17795 693746002343 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 693746002344 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 693746002345 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 693746002346 AAA-like domain; Region: AAA_10; pfam12846 693746002347 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 693746002348 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746002349 Sel1-like repeats; Region: SEL1; smart00671 693746002350 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 693746002351 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693746002352 active site 693746002353 metal binding site [ion binding]; metal-binding site 693746002354 interdomain interaction site; other site 693746002355 potential frameshift: common BLAST hit: gi|325288229|ref|YP_004264410.1| TRAG family protein 693746002356 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746002357 Walker A motif; other site 693746002358 ATP binding site [chemical binding]; other site 693746002359 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 693746002360 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 693746002361 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746002362 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746002363 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 693746002364 putative active site [active] 693746002365 catalytic site [active] 693746002366 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693746002367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746002368 ATP binding site [chemical binding]; other site 693746002369 putative Mg++ binding site [ion binding]; other site 693746002370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746002371 nucleotide binding region [chemical binding]; other site 693746002372 ATP-binding site [chemical binding]; other site 693746002373 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 693746002374 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 693746002375 DNA methylase; Region: N6_N4_Mtase; pfam01555 693746002376 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 693746002377 Restriction endonuclease [Defense mechanisms]; Region: COG3587 693746002378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746002379 ATP binding site [chemical binding]; other site 693746002380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693746002381 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 693746002382 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 693746002383 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 693746002384 generic binding surface II; other site 693746002385 generic binding surface I; other site 693746002386 HD domain; Region: HD; pfam01966 693746002387 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 693746002388 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746002389 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746002390 Integrase core domain; Region: rve; pfam00665 693746002391 PLD-like domain; Region: PLDc_2; pfam13091 693746002392 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693746002393 putative active site [active] 693746002394 catalytic site [active] 693746002395 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693746002396 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 693746002397 WYL domain; Region: WYL; pfam13280 693746002398 WYL domain; Region: WYL; pfam13280 693746002399 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 693746002400 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693746002401 Catalytic site [active] 693746002402 Domain of unknown function (DUF955); Region: DUF955; cl01076 693746002403 potential frameshift: common BLAST hit: gi|339443702|ref|YP_004709706.1| site-specific recombinase 693746002404 multiple promoter invertase; Provisional; Region: mpi; PRK13413 693746002405 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746002406 catalytic residues [active] 693746002407 catalytic nucleophile [active] 693746002408 Recombinase; Region: Recombinase; pfam07508 693746002409 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746002410 Low molecular weight phosphatase family; Region: LMWPc; cd00115 693746002411 active site 693746002412 DNA polymerase IV; Reviewed; Region: PRK03103 693746002413 Y-family of DNA polymerases; Region: PolY; cl12025 693746002414 active site 693746002415 DNA binding site [nucleotide binding] 693746002416 YolD-like protein; Region: YolD; pfam08863 693746002417 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 693746002418 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 693746002419 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 693746002420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693746002421 DEAD_2; Region: DEAD_2; pfam06733 693746002422 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 693746002423 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746002424 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746002425 catalytic residues [active] 693746002426 catalytic nucleophile [active] 693746002427 Recombinase; Region: Recombinase; pfam07508 693746002428 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746002429 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746002430 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746002431 DNA binding residues [nucleotide binding] 693746002432 alanine racemase; Reviewed; Region: alr; PRK00053 693746002433 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693746002434 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693746002435 catalytic residue [active] 693746002436 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 693746002437 trimer interface [polypeptide binding]; other site 693746002438 active site 693746002439 substrate binding site [chemical binding]; other site 693746002440 CoA binding site [chemical binding]; other site 693746002441 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 693746002442 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 693746002443 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693746002444 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 693746002445 VanW like protein; Region: VanW; pfam04294 693746002446 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746002447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746002448 dimer interface [polypeptide binding]; other site 693746002449 phosphorylation site [posttranslational modification] 693746002450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746002451 ATP binding site [chemical binding]; other site 693746002452 Mg2+ binding site [ion binding]; other site 693746002453 G-X-G motif; other site 693746002454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746002455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002456 active site 693746002457 phosphorylation site [posttranslational modification] 693746002458 intermolecular recognition site; other site 693746002459 dimerization interface [polypeptide binding]; other site 693746002460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746002461 DNA binding site [nucleotide binding] 693746002462 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746002463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746002464 non-specific DNA binding site [nucleotide binding]; other site 693746002465 salt bridge; other site 693746002466 sequence-specific DNA binding site [nucleotide binding]; other site 693746002467 transposase/IS protein; Provisional; Region: PRK09183 693746002468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746002469 Walker A motif; other site 693746002470 ATP binding site [chemical binding]; other site 693746002471 Walker B motif; other site 693746002472 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746002473 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746002474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746002475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746002476 Integrase core domain; Region: rve; pfam00665 693746002477 Integrase core domain; Region: rve_3; cl15866 693746002478 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 693746002479 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 693746002480 catalytic residues [active] 693746002481 aminotransferase; Validated; Region: PRK07777 693746002482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746002483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746002484 homodimer interface [polypeptide binding]; other site 693746002485 catalytic residue [active] 693746002486 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746002487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746002488 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746002489 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746002490 flavodoxin; Provisional; Region: PRK06242 693746002491 Transposase domain (DUF772); Region: DUF772; pfam05598 693746002492 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746002493 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746002494 Transposase domain (DUF772); Region: DUF772; pfam05598 693746002495 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746002496 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693746002497 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746002498 potential frameshift: common BLAST hit: gi|334339538|ref|YP_004544518.1| transposase IS4 family protein 693746002499 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746002500 Transposase domain (DUF772); Region: DUF772; pfam05598 693746002501 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 693746002502 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693746002503 DRTGG domain; Region: DRTGG; pfam07085 693746002504 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 693746002505 DHHA2 domain; Region: DHHA2; pfam02833 693746002506 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 693746002507 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 693746002508 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 693746002509 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 693746002510 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 693746002511 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 693746002512 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 693746002513 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 693746002514 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 693746002515 putative translocon binding site; other site 693746002516 protein-rRNA interface [nucleotide binding]; other site 693746002517 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 693746002518 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 693746002519 G-X-X-G motif; other site 693746002520 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 693746002521 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 693746002522 23S rRNA interface [nucleotide binding]; other site 693746002523 5S rRNA interface [nucleotide binding]; other site 693746002524 putative antibiotic binding site [chemical binding]; other site 693746002525 L25 interface [polypeptide binding]; other site 693746002526 L27 interface [polypeptide binding]; other site 693746002527 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 693746002528 23S rRNA interface [nucleotide binding]; other site 693746002529 putative translocon interaction site; other site 693746002530 signal recognition particle (SRP54) interaction site; other site 693746002531 L23 interface [polypeptide binding]; other site 693746002532 trigger factor interaction site; other site 693746002533 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 693746002534 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 693746002535 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 693746002536 RNA binding site [nucleotide binding]; other site 693746002537 FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1; Region: FYVE; cl17764 693746002538 Zn binding sites [ion binding]; other site 693746002539 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 693746002540 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 693746002541 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 693746002542 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 693746002543 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 693746002544 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 693746002545 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693746002546 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 693746002547 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 693746002548 5S rRNA interface [nucleotide binding]; other site 693746002549 L27 interface [polypeptide binding]; other site 693746002550 23S rRNA interface [nucleotide binding]; other site 693746002551 L5 interface [polypeptide binding]; other site 693746002552 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 693746002553 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 693746002554 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 693746002555 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 693746002556 23S rRNA binding site [nucleotide binding]; other site 693746002557 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 693746002558 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 693746002559 SecY translocase; Region: SecY; pfam00344 693746002560 adenylate kinase; Reviewed; Region: adk; PRK00279 693746002561 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 693746002562 AMP-binding site [chemical binding]; other site 693746002563 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 693746002564 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693746002565 active site 693746002566 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 693746002567 RNA binding site [nucleotide binding]; other site 693746002568 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 693746002569 rRNA binding site [nucleotide binding]; other site 693746002570 predicted 30S ribosome binding site; other site 693746002571 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 693746002572 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 693746002573 30S ribosomal protein S11; Validated; Region: PRK05309 693746002574 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 693746002575 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 693746002576 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746002577 RNA binding surface [nucleotide binding]; other site 693746002578 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 693746002579 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 693746002580 alphaNTD - beta interaction site [polypeptide binding]; other site 693746002581 alphaNTD homodimer interface [polypeptide binding]; other site 693746002582 alphaNTD - beta' interaction site [polypeptide binding]; other site 693746002583 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 693746002584 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 693746002585 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 693746002586 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746002587 metal binding site [ion binding]; metal-binding site 693746002588 active site 693746002589 I-site; other site 693746002590 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 693746002591 GIY-YIG motif/motif A; other site 693746002592 putative active site [active] 693746002593 putative metal binding site [ion binding]; other site 693746002594 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 693746002595 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 693746002596 AP (apurinic/apyrimidinic) site pocket; other site 693746002597 DNA interaction; other site 693746002598 Metal-binding active site; metal-binding site 693746002599 QueT transporter; Region: QueT; pfam06177 693746002600 Putative zinc-finger; Region: zf-HC2; pfam13490 693746002601 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 693746002602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746002603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746002604 DNA binding residues [nucleotide binding] 693746002605 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 693746002606 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693746002607 FMN binding site [chemical binding]; other site 693746002608 active site 693746002609 catalytic residues [active] 693746002610 substrate binding site [chemical binding]; other site 693746002611 stage II sporulation protein E; Region: spore_II_E; TIGR02865 693746002612 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 693746002613 Bacterial transcriptional activator domain; Region: BTAD; smart01043 693746002614 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693746002615 metal binding site [ion binding]; metal-binding site 693746002616 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693746002617 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693746002618 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693746002619 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 693746002620 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 693746002621 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746002622 Walker A motif; other site 693746002623 ATP binding site [chemical binding]; other site 693746002624 Walker B motif; other site 693746002625 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 693746002626 active site 693746002627 catalytic site [active] 693746002628 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 693746002629 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746002630 putative DNA binding site [nucleotide binding]; other site 693746002631 dimerization interface [polypeptide binding]; other site 693746002632 putative Zn2+ binding site [ion binding]; other site 693746002633 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 693746002634 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 693746002635 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 693746002636 Chromate transporter; Region: Chromate_transp; pfam02417 693746002637 Chromate transporter; Region: Chromate_transp; pfam02417 693746002638 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 693746002639 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 693746002640 putative kinase; Provisional; Region: PRK09954 693746002641 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 693746002642 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 693746002643 substrate binding site [chemical binding]; other site 693746002644 ATP binding site [chemical binding]; other site 693746002645 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746002646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746002647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746002648 Walker A/P-loop; other site 693746002649 ATP binding site [chemical binding]; other site 693746002650 Q-loop/lid; other site 693746002651 ABC transporter signature motif; other site 693746002652 Walker B; other site 693746002653 D-loop; other site 693746002654 H-loop/switch region; other site 693746002655 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 693746002656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746002657 RNA binding surface [nucleotide binding]; other site 693746002658 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 693746002659 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 693746002660 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693746002661 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693746002662 Divergent PAP2 family; Region: DUF212; pfam02681 693746002663 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693746002664 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693746002665 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 693746002666 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 693746002667 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 693746002668 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746002669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746002670 Uncharacterized conserved protein [Function unknown]; Region: COG0398 693746002671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746002672 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 693746002673 putative ADP-binding pocket [chemical binding]; other site 693746002674 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 693746002675 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 693746002676 active site 693746002677 catalytic site [active] 693746002678 substrate binding site [chemical binding]; other site 693746002679 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 693746002680 Protein of unknown function DUF45; Region: DUF45; pfam01863 693746002681 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 693746002682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746002683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746002684 homodimer interface [polypeptide binding]; other site 693746002685 catalytic residue [active] 693746002686 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746002687 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693746002688 FeS/SAM binding site; other site 693746002689 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 693746002690 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 693746002691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693746002692 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 693746002693 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693746002694 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 693746002695 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 693746002696 ATP cone domain; Region: ATP-cone; pfam03477 693746002697 Class III ribonucleotide reductase; Region: RNR_III; cd01675 693746002698 effector binding site; other site 693746002699 active site 693746002700 Zn binding site [ion binding]; other site 693746002701 glycine loop; other site 693746002702 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693746002703 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 693746002704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746002705 FeS/SAM binding site; other site 693746002706 Stage II sporulation protein; Region: SpoIID; pfam08486 693746002707 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 693746002708 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693746002709 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693746002710 Walker A/P-loop; other site 693746002711 ATP binding site [chemical binding]; other site 693746002712 Q-loop/lid; other site 693746002713 ABC transporter signature motif; other site 693746002714 Walker B; other site 693746002715 D-loop; other site 693746002716 H-loop/switch region; other site 693746002717 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693746002718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746002719 dimer interface [polypeptide binding]; other site 693746002720 conserved gate region; other site 693746002721 putative PBP binding loops; other site 693746002722 ABC-ATPase subunit interface; other site 693746002723 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693746002724 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693746002725 substrate binding pocket [chemical binding]; other site 693746002726 membrane-bound complex binding site; other site 693746002727 hinge residues; other site 693746002728 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 693746002729 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 693746002730 active site 693746002731 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 693746002732 active site 693746002733 phosphorylation site [posttranslational modification] 693746002734 intermolecular recognition site; other site 693746002735 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693746002736 nucleotidyl binding site; other site 693746002737 metal binding site [ion binding]; metal-binding site 693746002738 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693746002739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002740 active site 693746002741 phosphorylation site [posttranslational modification] 693746002742 intermolecular recognition site; other site 693746002743 dimerization interface [polypeptide binding]; other site 693746002744 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746002745 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 693746002746 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 693746002747 ATP cone domain; Region: ATP-cone; pfam03477 693746002748 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 693746002749 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746002750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746002751 active site 693746002752 DNA binding site [nucleotide binding] 693746002753 Int/Topo IB signature motif; other site 693746002754 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746002755 Putative transposase; Region: Y2_Tnp; pfam04986 693746002756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746002757 HTH-like domain; Region: HTH_21; pfam13276 693746002758 Integrase core domain; Region: rve; pfam00665 693746002759 Integrase core domain; Region: rve_3; pfam13683 693746002760 Transposase; Region: HTH_Tnp_1; pfam01527 693746002761 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693746002762 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693746002763 active site 693746002764 ATP binding site [chemical binding]; other site 693746002765 substrate binding site [chemical binding]; other site 693746002766 activation loop (A-loop); other site 693746002767 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 693746002768 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 693746002769 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 693746002770 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693746002771 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 693746002772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746002773 motif II; other site 693746002774 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 693746002775 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 693746002776 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 693746002777 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746002778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746002779 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746002780 S-layer homology domain; Region: SLH; pfam00395 693746002781 S-layer homology domain; Region: SLH; pfam00395 693746002782 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 693746002783 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746002784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746002785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746002786 DNA binding residues [nucleotide binding] 693746002787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 693746002788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746002789 dimerization interface [polypeptide binding]; other site 693746002790 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746002791 dimer interface [polypeptide binding]; other site 693746002792 phosphorylation site [posttranslational modification] 693746002793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746002794 ATP binding site [chemical binding]; other site 693746002795 Mg2+ binding site [ion binding]; other site 693746002796 G-X-G motif; other site 693746002797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746002798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002799 active site 693746002800 phosphorylation site [posttranslational modification] 693746002801 intermolecular recognition site; other site 693746002802 dimerization interface [polypeptide binding]; other site 693746002803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746002804 DNA binding site [nucleotide binding] 693746002805 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 693746002806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746002807 FeS/SAM binding site; other site 693746002808 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746002809 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693746002810 FeS/SAM binding site; other site 693746002811 Coenzyme A transferase; Region: CoA_trans; cl17247 693746002812 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 693746002813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746002814 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746002815 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746002816 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 693746002817 ligand binding site [chemical binding]; other site 693746002818 NAD binding site [chemical binding]; other site 693746002819 dimerization interface [polypeptide binding]; other site 693746002820 catalytic site [active] 693746002821 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 693746002822 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 693746002823 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 693746002824 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 693746002825 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 693746002826 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 693746002827 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 693746002828 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 693746002829 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 693746002830 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693746002831 carboxyltransferase (CT) interaction site; other site 693746002832 biotinylation site [posttranslational modification]; other site 693746002833 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 693746002834 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746002835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746002836 Walker A motif; other site 693746002837 ATP binding site [chemical binding]; other site 693746002838 Walker B motif; other site 693746002839 arginine finger; other site 693746002840 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 693746002841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746002842 metal binding site [ion binding]; metal-binding site 693746002843 active site 693746002844 I-site; other site 693746002845 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693746002846 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 693746002847 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 693746002848 MarR family; Region: MarR_2; pfam12802 693746002849 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746002850 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693746002851 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693746002852 nucleotide binding site [chemical binding]; other site 693746002853 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746002854 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 693746002855 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 693746002856 putative ligand binding site [chemical binding]; other site 693746002857 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693746002858 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746002859 Walker A/P-loop; other site 693746002860 ATP binding site [chemical binding]; other site 693746002861 Q-loop/lid; other site 693746002862 ABC transporter signature motif; other site 693746002863 Walker B; other site 693746002864 D-loop; other site 693746002865 H-loop/switch region; other site 693746002866 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693746002867 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693746002868 TM-ABC transporter signature motif; other site 693746002869 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 693746002870 N- and C-terminal domain interface [polypeptide binding]; other site 693746002871 D-xylulose kinase; Region: XylB; TIGR01312 693746002872 active site 693746002873 MgATP binding site [chemical binding]; other site 693746002874 catalytic site [active] 693746002875 metal binding site [ion binding]; metal-binding site 693746002876 xylulose binding site [chemical binding]; other site 693746002877 homodimer interface [polypeptide binding]; other site 693746002878 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 693746002879 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 693746002880 hexamer (dimer of trimers) interface [polypeptide binding]; other site 693746002881 substrate binding site [chemical binding]; other site 693746002882 trimer interface [polypeptide binding]; other site 693746002883 Mn binding site [ion binding]; other site 693746002884 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 693746002885 active site 693746002886 catalytic residues [active] 693746002887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693746002888 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693746002889 substrate binding pocket [chemical binding]; other site 693746002890 membrane-bound complex binding site; other site 693746002891 hinge residues; other site 693746002892 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 693746002893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746002894 dimer interface [polypeptide binding]; other site 693746002895 conserved gate region; other site 693746002896 putative PBP binding loops; other site 693746002897 ABC-ATPase subunit interface; other site 693746002898 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693746002899 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693746002900 Walker A/P-loop; other site 693746002901 ATP binding site [chemical binding]; other site 693746002902 Q-loop/lid; other site 693746002903 ABC transporter signature motif; other site 693746002904 Walker B; other site 693746002905 D-loop; other site 693746002906 H-loop/switch region; other site 693746002907 S-layer homology domain; Region: SLH; pfam00395 693746002908 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746002909 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 693746002910 putative metal binding site [ion binding]; other site 693746002911 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746002912 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746002913 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693746002914 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693746002915 TM-ABC transporter signature motif; other site 693746002916 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693746002917 TM-ABC transporter signature motif; other site 693746002918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693746002919 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693746002920 Walker A/P-loop; other site 693746002921 ATP binding site [chemical binding]; other site 693746002922 Q-loop/lid; other site 693746002923 ABC transporter signature motif; other site 693746002924 Walker B; other site 693746002925 D-loop; other site 693746002926 H-loop/switch region; other site 693746002927 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 693746002928 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693746002929 Walker A/P-loop; other site 693746002930 ATP binding site [chemical binding]; other site 693746002931 Q-loop/lid; other site 693746002932 ABC transporter signature motif; other site 693746002933 Walker B; other site 693746002934 D-loop; other site 693746002935 H-loop/switch region; other site 693746002936 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 693746002937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746002938 catalytic residue [active] 693746002939 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 693746002940 substrate binding site [chemical binding]; other site 693746002941 active site 693746002942 catalytic residues [active] 693746002943 heterodimer interface [polypeptide binding]; other site 693746002944 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 693746002945 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693746002946 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693746002947 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746002948 Walker A/P-loop; other site 693746002949 ATP binding site [chemical binding]; other site 693746002950 Q-loop/lid; other site 693746002951 ABC transporter signature motif; other site 693746002952 Walker B; other site 693746002953 D-loop; other site 693746002954 H-loop/switch region; other site 693746002955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746002956 ATP binding site [chemical binding]; other site 693746002957 Q-loop/lid; other site 693746002958 ABC transporter signature motif; other site 693746002959 Walker B; other site 693746002960 D-loop; other site 693746002961 H-loop/switch region; other site 693746002962 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693746002963 TM-ABC transporter signature motif; other site 693746002964 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746002965 D-xylulose kinase; Region: XylB; TIGR01312 693746002966 nucleotide binding site [chemical binding]; other site 693746002967 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 693746002968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746002969 active site 693746002970 phosphorylation site [posttranslational modification] 693746002971 intermolecular recognition site; other site 693746002972 dimerization interface [polypeptide binding]; other site 693746002973 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746002974 Zn2+ binding site [ion binding]; other site 693746002975 Mg2+ binding site [ion binding]; other site 693746002976 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746002977 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746002978 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746002979 putative active site [active] 693746002980 heme pocket [chemical binding]; other site 693746002981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746002982 putative active site [active] 693746002983 heme pocket [chemical binding]; other site 693746002984 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746002985 metal binding site [ion binding]; metal-binding site 693746002986 active site 693746002987 I-site; other site 693746002988 GTPase CgtA; Reviewed; Region: obgE; PRK12297 693746002989 GTP1/OBG; Region: GTP1_OBG; pfam01018 693746002990 Obg GTPase; Region: Obg; cd01898 693746002991 G1 box; other site 693746002992 GTP/Mg2+ binding site [chemical binding]; other site 693746002993 Switch I region; other site 693746002994 G2 box; other site 693746002995 G3 box; other site 693746002996 Switch II region; other site 693746002997 G4 box; other site 693746002998 G5 box; other site 693746002999 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 693746003000 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 693746003001 Protein of unknown function (DUF464); Region: DUF464; pfam04327 693746003002 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 693746003003 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 693746003004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746003005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746003006 Coenzyme A binding pocket [chemical binding]; other site 693746003007 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693746003008 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693746003009 trimer interface [polypeptide binding]; other site 693746003010 active site 693746003011 substrate binding site [chemical binding]; other site 693746003012 CoA binding site [chemical binding]; other site 693746003013 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 693746003014 Pyruvate formate lyase; Region: PFL; pfam02901 693746003015 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 693746003016 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 693746003017 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 693746003018 Entner-Doudoroff aldolase; Region: eda; TIGR01182 693746003019 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 693746003020 active site 693746003021 intersubunit interface [polypeptide binding]; other site 693746003022 catalytic residue [active] 693746003023 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693746003024 substrate binding site [chemical binding]; other site 693746003025 ATP binding site [chemical binding]; other site 693746003026 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 693746003027 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 693746003028 NADP binding site [chemical binding]; other site 693746003029 homodimer interface [polypeptide binding]; other site 693746003030 active site 693746003031 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 693746003032 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693746003033 active site 693746003034 metal binding site [ion binding]; metal-binding site 693746003035 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 693746003036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746003037 NAD(P) binding site [chemical binding]; other site 693746003038 active site 693746003039 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693746003040 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 693746003041 NAD(P) binding site [chemical binding]; other site 693746003042 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 693746003043 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 693746003044 ligand binding site [chemical binding]; other site 693746003045 NAD binding site [chemical binding]; other site 693746003046 catalytic site [active] 693746003047 DctM-like transporters; Region: DctM; pfam06808 693746003048 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746003049 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693746003050 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746003051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693746003052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693746003053 DNA binding site [nucleotide binding] 693746003054 domain linker motif; other site 693746003055 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 693746003056 putative dimerization interface [polypeptide binding]; other site 693746003057 putative ligand binding site [chemical binding]; other site 693746003058 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 693746003059 substrate binding site [chemical binding]; other site 693746003060 dimer interface [polypeptide binding]; other site 693746003061 ATP binding site [chemical binding]; other site 693746003062 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693746003063 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693746003064 DNA binding site [nucleotide binding] 693746003065 domain linker motif; other site 693746003066 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693746003067 dimerization interface [polypeptide binding]; other site 693746003068 ligand binding site [chemical binding]; other site 693746003069 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 693746003070 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 693746003071 metal binding site [ion binding]; metal-binding site 693746003072 dimer interface [polypeptide binding]; other site 693746003073 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 693746003074 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 693746003075 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 693746003076 metal binding site [ion binding]; metal-binding site 693746003077 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 693746003078 active site 693746003079 tetramer interface [polypeptide binding]; other site 693746003080 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693746003081 TM-ABC transporter signature motif; other site 693746003082 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693746003083 TM-ABC transporter signature motif; other site 693746003084 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693746003085 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746003086 Walker A/P-loop; other site 693746003087 ATP binding site [chemical binding]; other site 693746003088 Q-loop/lid; other site 693746003089 ABC transporter signature motif; other site 693746003090 Walker B; other site 693746003091 D-loop; other site 693746003092 H-loop/switch region; other site 693746003093 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693746003094 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 693746003095 ligand binding site [chemical binding]; other site 693746003096 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 693746003097 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746003098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746003099 active site 693746003100 S-layer homology domain; Region: SLH; pfam00395 693746003101 LysE type translocator; Region: LysE; cl00565 693746003102 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693746003103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746003104 putative DNA binding site [nucleotide binding]; other site 693746003105 putative Zn2+ binding site [ion binding]; other site 693746003106 AsnC family; Region: AsnC_trans_reg; pfam01037 693746003107 putative transposase OrfB; Reviewed; Region: PHA02517 693746003108 Integrase core domain; Region: rve; pfam00665 693746003109 Integrase core domain; Region: rve_2; pfam13333 693746003110 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 693746003111 HTH domain; Region: HTH_11; pfam08279 693746003112 3H domain; Region: 3H; pfam02829 693746003113 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 693746003114 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 693746003115 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 693746003116 active site 693746003117 catalytic site [active] 693746003118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693746003119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693746003120 DNA binding site [nucleotide binding] 693746003121 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693746003122 ligand binding site [chemical binding]; other site 693746003123 dimerization interface [polypeptide binding]; other site 693746003124 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693746003125 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693746003126 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693746003127 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746003128 Walker A/P-loop; other site 693746003129 ATP binding site [chemical binding]; other site 693746003130 Q-loop/lid; other site 693746003131 ABC transporter signature motif; other site 693746003132 Walker B; other site 693746003133 D-loop; other site 693746003134 H-loop/switch region; other site 693746003135 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693746003136 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693746003137 TM-ABC transporter signature motif; other site 693746003138 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693746003139 TM-ABC transporter signature motif; other site 693746003140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746003141 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693746003142 nucleotide binding site [chemical binding]; other site 693746003143 L-arabinose isomerase; Provisional; Region: PRK02929 693746003144 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 693746003145 hexamer (dimer of trimers) interface [polypeptide binding]; other site 693746003146 trimer interface [polypeptide binding]; other site 693746003147 substrate binding site [chemical binding]; other site 693746003148 Mn binding site [ion binding]; other site 693746003149 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 693746003150 intersubunit interface [polypeptide binding]; other site 693746003151 active site 693746003152 Zn2+ binding site [ion binding]; other site 693746003153 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693746003154 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 693746003155 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693746003156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746003157 D-galactonate transporter; Region: 2A0114; TIGR00893 693746003158 putative substrate translocation pore; other site 693746003159 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 693746003160 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746003161 nucleotide binding site [chemical binding]; other site 693746003162 Uncharacterized conserved protein [Function unknown]; Region: COG5476 693746003163 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 693746003164 MlrC C-terminus; Region: MlrC_C; pfam07171 693746003165 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 693746003166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746003167 catalytic residue [active] 693746003168 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693746003169 catalytic residue [active] 693746003170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746003171 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746003172 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 693746003173 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746003174 putative homodimer interface [polypeptide binding]; other site 693746003175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 693746003176 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 693746003177 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 693746003178 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 693746003179 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693746003180 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746003181 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746003182 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693746003183 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 693746003184 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693746003185 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693746003186 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746003187 catalytic loop [active] 693746003188 iron binding site [ion binding]; other site 693746003189 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693746003190 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693746003191 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746003192 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746003193 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693746003194 Ligand binding site; other site 693746003195 metal-binding site 693746003196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693746003197 active site 693746003198 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 693746003199 Cache domain; Region: Cache_1; pfam02743 693746003200 HAMP domain; Region: HAMP; pfam00672 693746003201 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746003202 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746003203 dimer interface [polypeptide binding]; other site 693746003204 putative CheW interface [polypeptide binding]; other site 693746003205 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693746003206 Stage II sporulation protein; Region: SpoIID; pfam08486 693746003207 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 693746003208 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 693746003209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 693746003210 active site residue [active] 693746003211 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 693746003212 catalytic residues [active] 693746003213 Transcriptional regulator; Region: Rrf2; pfam02082 693746003214 4Fe-4S binding domain; Region: Fer4_5; pfam12801 693746003215 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693746003216 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746003217 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746003218 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 693746003219 DNA binding residues [nucleotide binding] 693746003220 dimer interface [polypeptide binding]; other site 693746003221 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 693746003222 sporulation sigma factor SigK; Reviewed; Region: PRK05803 693746003223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746003224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746003225 DNA binding residues [nucleotide binding] 693746003226 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746003227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746003228 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 693746003229 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 693746003230 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 693746003231 Formiminotransferase domain; Region: FTCD; pfam02971 693746003232 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 693746003233 HutD; Region: HutD; cl01532 693746003234 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 693746003235 Potassium binding sites [ion binding]; other site 693746003236 Cesium cation binding sites [ion binding]; other site 693746003237 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 693746003238 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 693746003239 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 693746003240 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746003241 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693746003242 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 693746003243 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 693746003244 AAA ATPase domain; Region: AAA_16; pfam13191 693746003245 imidazolonepropionase; Validated; Region: PRK09356 693746003246 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 693746003247 active site 693746003248 urocanate hydratase; Provisional; Region: PRK05414 693746003249 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 693746003250 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 693746003251 Formiminotransferase domain; Region: FTCD; pfam02971 693746003252 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 693746003253 oligomer interface [polypeptide binding]; other site 693746003254 active site 693746003255 Mn binding site [ion binding]; other site 693746003256 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693746003257 catalytic triad [active] 693746003258 conserved cis-peptide bond; other site 693746003259 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 693746003260 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746003261 Beta-Casp domain; Region: Beta-Casp; smart01027 693746003262 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 693746003263 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 693746003264 TRAM domain; Region: TRAM; cl01282 693746003265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746003266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003267 S-adenosylmethionine binding site [chemical binding]; other site 693746003268 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 693746003269 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693746003270 tetramer interface [polypeptide binding]; other site 693746003271 catalytic Zn binding site [ion binding]; other site 693746003272 NADP binding site [chemical binding]; other site 693746003273 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746003274 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746003275 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 693746003276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693746003277 Walker A/P-loop; other site 693746003278 ATP binding site [chemical binding]; other site 693746003279 Q-loop/lid; other site 693746003280 ABC transporter signature motif; other site 693746003281 Walker B; other site 693746003282 D-loop; other site 693746003283 H-loop/switch region; other site 693746003284 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693746003285 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 693746003286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693746003287 Walker A/P-loop; other site 693746003288 ATP binding site [chemical binding]; other site 693746003289 Q-loop/lid; other site 693746003290 ABC transporter signature motif; other site 693746003291 Walker B; other site 693746003292 D-loop; other site 693746003293 H-loop/switch region; other site 693746003294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693746003295 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693746003296 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 693746003297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693746003298 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 693746003299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746003300 dimer interface [polypeptide binding]; other site 693746003301 conserved gate region; other site 693746003302 putative PBP binding loops; other site 693746003303 ABC-ATPase subunit interface; other site 693746003304 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693746003305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746003306 dimer interface [polypeptide binding]; other site 693746003307 conserved gate region; other site 693746003308 putative PBP binding loops; other site 693746003309 ABC-ATPase subunit interface; other site 693746003310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003311 S-adenosylmethionine binding site [chemical binding]; other site 693746003312 Domain of unknown function (DUF3842); Region: DUF3842; pfam12953 693746003313 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 693746003314 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 693746003315 Ligand Binding Site [chemical binding]; other site 693746003316 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 693746003317 AIR carboxylase; Region: AIRC; smart01001 693746003318 Protein of unknown function DUF111; Region: DUF111; pfam01969 693746003319 oligoendopeptidase F; Region: pepF; TIGR00181 693746003320 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 693746003321 active site 693746003322 Zn binding site [ion binding]; other site 693746003323 Chloramphenicol acetyltransferase; Region: CAT; cl02008 693746003324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746003325 HTH-like domain; Region: HTH_21; pfam13276 693746003326 Integrase core domain; Region: rve; pfam00665 693746003327 Integrase core domain; Region: rve_3; pfam13683 693746003328 Transposase; Region: HTH_Tnp_1; pfam01527 693746003329 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 693746003330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746003331 FeS/SAM binding site; other site 693746003332 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 693746003333 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693746003334 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 693746003335 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693746003336 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746003337 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746003338 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746003339 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 693746003340 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 693746003341 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 693746003342 homodimer interface [polypeptide binding]; other site 693746003343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746003344 catalytic residue [active] 693746003345 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693746003346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003347 S-adenosylmethionine binding site [chemical binding]; other site 693746003348 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 693746003349 putative active site [active] 693746003350 Mn binding site [ion binding]; other site 693746003351 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 693746003352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746003353 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 693746003354 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 693746003355 dimer interface [polypeptide binding]; other site 693746003356 active site 693746003357 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693746003358 catalytic residues [active] 693746003359 substrate binding site [chemical binding]; other site 693746003360 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 693746003361 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746003362 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 693746003363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746003364 FeS/SAM binding site; other site 693746003365 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 693746003366 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746003367 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746003368 S-layer homology domain; Region: SLH; pfam00395 693746003369 S-layer homology domain; Region: SLH; pfam00395 693746003370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746003371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746003372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746003373 dimerization interface [polypeptide binding]; other site 693746003374 putative phosphoketolase; Provisional; Region: PRK05261 693746003375 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 693746003376 TPP-binding site; other site 693746003377 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 693746003378 XFP C-terminal domain; Region: XFP_C; pfam09363 693746003379 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746003380 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746003381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746003382 DNA binding residues [nucleotide binding] 693746003383 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 693746003384 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693746003385 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693746003386 dimer interface [polypeptide binding]; other site 693746003387 ssDNA binding site [nucleotide binding]; other site 693746003388 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693746003389 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 693746003390 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 693746003391 MPT binding site; other site 693746003392 trimer interface [polypeptide binding]; other site 693746003393 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 693746003394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003395 Walker A/P-loop; other site 693746003396 ATP binding site [chemical binding]; other site 693746003397 Q-loop/lid; other site 693746003398 ABC transporter signature motif; other site 693746003399 Walker B; other site 693746003400 D-loop; other site 693746003401 H-loop/switch region; other site 693746003402 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693746003403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746003404 dimer interface [polypeptide binding]; other site 693746003405 conserved gate region; other site 693746003406 putative PBP binding loops; other site 693746003407 ABC-ATPase subunit interface; other site 693746003408 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 693746003409 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 693746003410 putative MPT binding site; other site 693746003411 MOSC domain; Region: MOSC; pfam03473 693746003412 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 693746003413 trimer interface [polypeptide binding]; other site 693746003414 dimer interface [polypeptide binding]; other site 693746003415 putative active site [active] 693746003416 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 693746003417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746003418 FeS/SAM binding site; other site 693746003419 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 693746003420 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 693746003421 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 693746003422 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 693746003423 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 693746003424 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 693746003425 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 693746003426 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 693746003427 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 693746003428 phosphopeptide binding site; other site 693746003429 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 693746003430 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693746003431 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 693746003432 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 693746003433 active site 693746003434 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693746003435 substrate binding site [chemical binding]; other site 693746003436 catalytic residues [active] 693746003437 dimer interface [polypeptide binding]; other site 693746003438 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 693746003439 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 693746003440 CPxP motif; other site 693746003441 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746003442 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746003443 catalytic residue [active] 693746003444 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 693746003445 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 693746003446 FMN binding site [chemical binding]; other site 693746003447 dimer interface [polypeptide binding]; other site 693746003448 Integrase core domain; Region: rve_3; cl15866 693746003449 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 693746003450 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 693746003451 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 693746003452 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 693746003453 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 693746003454 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746003455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746003456 active site 693746003457 phosphorylation site [posttranslational modification] 693746003458 intermolecular recognition site; other site 693746003459 dimerization interface [polypeptide binding]; other site 693746003460 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746003461 DNA binding site [nucleotide binding] 693746003462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746003463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746003464 dimerization interface [polypeptide binding]; other site 693746003465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746003466 dimer interface [polypeptide binding]; other site 693746003467 phosphorylation site [posttranslational modification] 693746003468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746003469 ATP binding site [chemical binding]; other site 693746003470 Mg2+ binding site [ion binding]; other site 693746003471 G-X-G motif; other site 693746003472 Sporulation and spore germination; Region: Germane; pfam10646 693746003473 Sporulation and spore germination; Region: Germane; pfam10646 693746003474 Tic20-like protein; Region: Tic20; pfam09685 693746003475 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 693746003476 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 693746003477 putative active site [active] 693746003478 metal binding site [ion binding]; metal-binding site 693746003479 homodimer binding site [polypeptide binding]; other site 693746003480 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 693746003481 putative deacylase active site [active] 693746003482 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 693746003483 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 693746003484 active site 693746003485 metal binding site [ion binding]; metal-binding site 693746003486 DNA binding site [nucleotide binding] 693746003487 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 693746003488 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 693746003489 active site 693746003490 homodimer interface [polypeptide binding]; other site 693746003491 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 693746003492 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 693746003493 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693746003494 minor groove reading motif; other site 693746003495 helix-hairpin-helix signature motif; other site 693746003496 active site 693746003497 Probable zinc-binding domain; Region: zf-trcl; pfam13451 693746003498 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 693746003499 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 693746003500 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 693746003501 Phage XkdN-like protein; Region: XkdN; pfam08890 693746003502 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 693746003503 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; cl19502 693746003504 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693746003505 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693746003506 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693746003507 protein binding site [polypeptide binding]; other site 693746003508 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746003509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746003510 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746003511 dimerization interface [polypeptide binding]; other site 693746003512 Predicted transcriptional regulators [Transcription]; Region: COG1725 693746003513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746003514 DNA-binding site [nucleotide binding]; DNA binding site 693746003515 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746003516 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746003517 Walker A/P-loop; other site 693746003518 ATP binding site [chemical binding]; other site 693746003519 Q-loop/lid; other site 693746003520 ABC transporter signature motif; other site 693746003521 Walker B; other site 693746003522 D-loop; other site 693746003523 H-loop/switch region; other site 693746003524 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 693746003525 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 693746003526 ATP-binding site [chemical binding]; other site 693746003527 Sugar specificity; other site 693746003528 Pyrimidine base specificity; other site 693746003529 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 693746003530 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 693746003531 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 693746003532 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 693746003533 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 693746003534 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 693746003535 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693746003536 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 693746003537 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746003538 dimer interface [polypeptide binding]; other site 693746003539 PYR/PP interface [polypeptide binding]; other site 693746003540 TPP binding site [chemical binding]; other site 693746003541 substrate binding site [chemical binding]; other site 693746003542 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 693746003543 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 693746003544 TPP-binding site [chemical binding]; other site 693746003545 putative dimer interface [polypeptide binding]; other site 693746003546 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 693746003547 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693746003548 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 693746003549 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693746003550 homodimer interface [polypeptide binding]; other site 693746003551 NADP binding site [chemical binding]; other site 693746003552 substrate binding site [chemical binding]; other site 693746003553 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746003554 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 693746003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746003556 dimer interface [polypeptide binding]; other site 693746003557 conserved gate region; other site 693746003558 putative PBP binding loops; other site 693746003559 ABC-ATPase subunit interface; other site 693746003560 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 693746003561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746003562 dimer interface [polypeptide binding]; other site 693746003563 conserved gate region; other site 693746003564 putative PBP binding loops; other site 693746003565 ABC-ATPase subunit interface; other site 693746003566 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 693746003567 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 693746003568 Walker A/P-loop; other site 693746003569 ATP binding site [chemical binding]; other site 693746003570 Q-loop/lid; other site 693746003571 ABC transporter signature motif; other site 693746003572 Walker B; other site 693746003573 D-loop; other site 693746003574 H-loop/switch region; other site 693746003575 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 693746003576 PhoU domain; Region: PhoU; pfam01895 693746003577 PhoU domain; Region: PhoU; pfam01895 693746003578 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746003579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746003580 active site 693746003581 phosphorylation site [posttranslational modification] 693746003582 intermolecular recognition site; other site 693746003583 dimerization interface [polypeptide binding]; other site 693746003584 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746003585 DNA binding site [nucleotide binding] 693746003586 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 693746003587 PAS domain; Region: PAS_8; pfam13188 693746003588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746003589 dimer interface [polypeptide binding]; other site 693746003590 phosphorylation site [posttranslational modification] 693746003591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746003592 ATP binding site [chemical binding]; other site 693746003593 Mg2+ binding site [ion binding]; other site 693746003594 G-X-G motif; other site 693746003595 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746003596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746003597 non-specific DNA binding site [nucleotide binding]; other site 693746003598 salt bridge; other site 693746003599 sequence-specific DNA binding site [nucleotide binding]; other site 693746003600 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 693746003601 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 693746003602 generic binding surface II; other site 693746003603 ssDNA binding site; other site 693746003604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746003605 ATP binding site [chemical binding]; other site 693746003606 putative Mg++ binding site [ion binding]; other site 693746003607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746003608 nucleotide binding region [chemical binding]; other site 693746003609 ATP-binding site [chemical binding]; other site 693746003610 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 693746003611 folate binding site [chemical binding]; other site 693746003612 NADP+ binding site [chemical binding]; other site 693746003613 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 693746003614 dimerization interface [polypeptide binding]; other site 693746003615 active site 693746003616 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693746003617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746003618 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746003619 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746003620 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746003621 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 693746003622 Na2 binding site [ion binding]; other site 693746003623 putative substrate binding site 1 [chemical binding]; other site 693746003624 Na binding site 1 [ion binding]; other site 693746003625 putative substrate binding site 2 [chemical binding]; other site 693746003626 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 693746003627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693746003628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746003629 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 693746003630 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 693746003631 active site 693746003632 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 693746003633 active site 2 [active] 693746003634 active site 1 [active] 693746003635 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 693746003636 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 693746003637 active site 693746003638 substrate binding site [chemical binding]; other site 693746003639 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 693746003640 FMN binding site [chemical binding]; other site 693746003641 putative catalytic residues [active] 693746003642 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 693746003643 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 693746003644 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 693746003645 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 693746003646 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase; Region: TPM; cl01535 693746003647 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693746003648 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 693746003649 NodB motif; other site 693746003650 active site 693746003651 catalytic site [active] 693746003652 Preprotein translocase SecG subunit; Region: SecG; pfam03840 693746003653 LexA repressor; Validated; Region: PRK00215 693746003654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746003655 putative Zn2+ binding site [ion binding]; other site 693746003656 putative DNA binding site [nucleotide binding]; other site 693746003657 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693746003658 Catalytic site [active] 693746003659 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693746003660 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 693746003661 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 693746003662 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 693746003663 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693746003664 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 693746003665 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746003666 nucleotide binding region [chemical binding]; other site 693746003667 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 693746003668 SEC-C motif; Region: SEC-C; pfam02810 693746003669 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 693746003670 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 693746003671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693746003672 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 693746003673 glycerol kinase; Provisional; Region: glpK; PRK00047 693746003674 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 693746003675 N- and C-terminal domain interface [polypeptide binding]; other site 693746003676 active site 693746003677 MgATP binding site [chemical binding]; other site 693746003678 catalytic site [active] 693746003679 metal binding site [ion binding]; metal-binding site 693746003680 glycerol binding site [chemical binding]; other site 693746003681 homotetramer interface [polypeptide binding]; other site 693746003682 homodimer interface [polypeptide binding]; other site 693746003683 FBP binding site [chemical binding]; other site 693746003684 protein IIAGlc interface [polypeptide binding]; other site 693746003685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 693746003686 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 693746003687 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 693746003688 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746003689 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 693746003690 Fe-S cluster binding site [ion binding]; other site 693746003691 active site 693746003692 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 693746003693 DAK2 domain; Region: Dak2; pfam02734 693746003694 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 693746003695 Asp23 family; Region: Asp23; pfam03780 693746003696 Predicted permeases [General function prediction only]; Region: RarD; COG2962 693746003697 EamA-like transporter family; Region: EamA; pfam00892 693746003698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003699 S-adenosylmethionine binding site [chemical binding]; other site 693746003700 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 693746003701 active site 693746003702 nucleotide binding site [chemical binding]; other site 693746003703 HIGH motif; other site 693746003704 KMSKS motif; other site 693746003705 MraZ protein; Region: MraZ; pfam02381 693746003706 cell division protein MraZ; Reviewed; Region: PRK00326 693746003707 MraZ protein; Region: MraZ; pfam02381 693746003708 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 693746003709 Septum formation initiator; Region: DivIC; cl17659 693746003710 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 693746003711 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 693746003712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693746003713 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 693746003714 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693746003715 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 693746003716 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693746003717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746003718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693746003719 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 693746003720 Mg++ binding site [ion binding]; other site 693746003721 putative catalytic motif [active] 693746003722 putative substrate binding site [chemical binding]; other site 693746003723 cell division protein FtsW; Region: ftsW; TIGR02614 693746003724 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 693746003725 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 693746003726 active site 693746003727 homodimer interface [polypeptide binding]; other site 693746003728 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 693746003729 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746003730 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746003731 P-loop; other site 693746003732 Magnesium ion binding site [ion binding]; other site 693746003733 ParB-like nuclease domain; Region: ParBc; pfam02195 693746003734 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 693746003735 MutS domain I; Region: MutS_I; pfam01624 693746003736 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 693746003737 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693746003738 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 693746003739 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 693746003740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746003741 ATP binding site [chemical binding]; other site 693746003742 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 693746003743 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693746003744 Protein of unknown function (DUF3848); Region: DUF3848; pfam12959 693746003745 Protein of unknown function (DUF3849); Region: DUF3849; pfam12960 693746003746 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 693746003747 Toprim-like; Region: Toprim_2; pfam13155 693746003748 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 693746003749 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746003750 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 693746003751 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 693746003752 active site 693746003753 catalytic site [active] 693746003754 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 693746003755 AAA domain; Region: AAA_14; pfam13173 693746003756 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 693746003757 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693746003758 TQXA domain; Region: TQXA_dom; TIGR03934 693746003759 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003760 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003761 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003762 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003763 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003764 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003765 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003766 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003767 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003768 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003769 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003770 Cna protein B-type domain; Region: Cna_B; pfam05738 693746003771 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 693746003772 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746003773 Walker A motif; other site 693746003774 ATP binding site [chemical binding]; other site 693746003775 Walker B motif; other site 693746003776 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746003777 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746003778 Integrase core domain; Region: rve; pfam00665 693746003779 PrgI family protein; Region: PrgI; pfam12666 693746003780 AAA-like domain; Region: AAA_10; pfam12846 693746003781 Domain of unknown function DUF87; Region: DUF87; cl19135 693746003782 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746003783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746003784 non-specific DNA binding site [nucleotide binding]; other site 693746003785 salt bridge; other site 693746003786 sequence-specific DNA binding site [nucleotide binding]; other site 693746003787 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693746003788 NlpC/P60 family; Region: NLPC_P60; cl17555 693746003789 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 693746003790 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693746003791 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 693746003792 Walker A motif; other site 693746003793 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 693746003794 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 693746003795 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 693746003796 P loop nucleotide binding; other site 693746003797 switch II; other site 693746003798 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 693746003799 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 693746003800 P loop nucleotide binding; other site 693746003801 switch II; other site 693746003802 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 693746003803 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 693746003804 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 693746003805 trimerization site [polypeptide binding]; other site 693746003806 active site 693746003807 Predicted DNA-binding proteins [General function prediction only]; Region: COG1342 693746003808 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746003809 DNA binding residues [nucleotide binding] 693746003810 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693746003811 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746003812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746003813 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746003814 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746003815 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693746003816 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693746003817 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 693746003818 Probable zinc-binding domain; Region: zf-trcl; pfam13451 693746003819 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 693746003820 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693746003821 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693746003822 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693746003823 TIGR03943 family protein; Region: TIGR03943 693746003824 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746003825 Predicted permeases [General function prediction only]; Region: COG0701 693746003826 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 693746003827 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 693746003828 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693746003829 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693746003830 metal binding site 2 [ion binding]; metal-binding site 693746003831 putative DNA binding helix; other site 693746003832 metal binding site 1 [ion binding]; metal-binding site 693746003833 dimer interface [polypeptide binding]; other site 693746003834 structural Zn2+ binding site [ion binding]; other site 693746003835 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693746003836 ABC-ATPase subunit interface; other site 693746003837 dimer interface [polypeptide binding]; other site 693746003838 putative PBP binding regions; other site 693746003839 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 693746003840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003841 Walker A/P-loop; other site 693746003842 ATP binding site [chemical binding]; other site 693746003843 Q-loop/lid; other site 693746003844 ABC transporter signature motif; other site 693746003845 Walker B; other site 693746003846 D-loop; other site 693746003847 H-loop/switch region; other site 693746003848 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 693746003849 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 693746003850 metal binding site [ion binding]; metal-binding site 693746003851 Probable zinc-binding domain; Region: zf-trcl; pfam13451 693746003852 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 693746003853 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 693746003854 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 693746003855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746003856 dimer interface [polypeptide binding]; other site 693746003857 conserved gate region; other site 693746003858 putative PBP binding loops; other site 693746003859 ABC-ATPase subunit interface; other site 693746003860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003861 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 693746003862 Walker A/P-loop; other site 693746003863 ATP binding site [chemical binding]; other site 693746003864 Q-loop/lid; other site 693746003865 ABC transporter signature motif; other site 693746003866 Walker B; other site 693746003867 D-loop; other site 693746003868 H-loop/switch region; other site 693746003869 Domain of unknown function (DUF364); Region: DUF364; pfam04016 693746003870 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 693746003871 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746003872 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693746003873 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693746003874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746003875 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693746003876 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746003877 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746003878 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746003879 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746003880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746003881 putative Zn2+ binding site [ion binding]; other site 693746003882 putative DNA binding site [nucleotide binding]; other site 693746003883 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 693746003884 Condensation domain; Region: Condensation; cl19241 693746003885 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746003886 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746003887 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746003888 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746003889 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746003890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003891 Walker A/P-loop; other site 693746003892 ATP binding site [chemical binding]; other site 693746003893 Q-loop/lid; other site 693746003894 ABC transporter signature motif; other site 693746003895 Walker B; other site 693746003896 D-loop; other site 693746003897 H-loop/switch region; other site 693746003898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746003899 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746003900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003901 Walker A/P-loop; other site 693746003902 ATP binding site [chemical binding]; other site 693746003903 Q-loop/lid; other site 693746003904 ABC transporter signature motif; other site 693746003905 Walker B; other site 693746003906 D-loop; other site 693746003907 H-loop/switch region; other site 693746003908 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746003909 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746003910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003911 Walker B; other site 693746003912 D-loop; other site 693746003913 H-loop/switch region; other site 693746003914 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693746003915 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693746003916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003917 S-adenosylmethionine binding site [chemical binding]; other site 693746003918 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746003919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746003920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746003921 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 693746003922 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693746003923 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746003924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003925 S-adenosylmethionine binding site [chemical binding]; other site 693746003926 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 693746003927 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693746003928 catalytic core [active] 693746003929 Domain of unknown function (DUF1693); Region: DUF1693; pfam07984 693746003930 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 693746003931 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746003932 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746003933 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746003934 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746003935 FeoA domain; Region: FeoA; pfam04023 693746003936 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 693746003937 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 693746003938 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693746003939 G1 box; other site 693746003940 GTP/Mg2+ binding site [chemical binding]; other site 693746003941 Switch I region; other site 693746003942 G2 box; other site 693746003943 G3 box; other site 693746003944 Switch II region; other site 693746003945 G4 box; other site 693746003946 G5 box; other site 693746003947 Nucleoside recognition; Region: Gate; pfam07670 693746003948 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693746003949 Nucleoside recognition; Region: Gate; pfam07670 693746003950 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746003951 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693746003952 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746003953 Zn2+ binding site [ion binding]; other site 693746003954 Mg2+ binding site [ion binding]; other site 693746003955 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746003956 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746003957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003958 Walker A/P-loop; other site 693746003959 ATP binding site [chemical binding]; other site 693746003960 Q-loop/lid; other site 693746003961 ABC transporter signature motif; other site 693746003962 Walker B; other site 693746003963 D-loop; other site 693746003964 H-loop/switch region; other site 693746003965 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746003966 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746003967 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003968 Walker A/P-loop; other site 693746003969 ATP binding site [chemical binding]; other site 693746003970 Q-loop/lid; other site 693746003971 ABC transporter signature motif; other site 693746003972 Walker B; other site 693746003973 D-loop; other site 693746003974 H-loop/switch region; other site 693746003975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746003976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746003977 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693746003978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746003979 S-adenosylmethionine binding site [chemical binding]; other site 693746003980 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746003981 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746003982 putative Zn2+ binding site [ion binding]; other site 693746003983 putative DNA binding site [nucleotide binding]; other site 693746003984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746003985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746003986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003987 Walker A/P-loop; other site 693746003988 ATP binding site [chemical binding]; other site 693746003989 Q-loop/lid; other site 693746003990 ABC transporter signature motif; other site 693746003991 Walker B; other site 693746003992 D-loop; other site 693746003993 H-loop/switch region; other site 693746003994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746003995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746003996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746003997 Walker A/P-loop; other site 693746003998 ATP binding site [chemical binding]; other site 693746003999 Q-loop/lid; other site 693746004000 ABC transporter signature motif; other site 693746004001 Walker B; other site 693746004002 D-loop; other site 693746004003 H-loop/switch region; other site 693746004004 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 693746004005 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693746004006 intersubunit interface [polypeptide binding]; other site 693746004007 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693746004008 ABC-ATPase subunit interface; other site 693746004009 dimer interface [polypeptide binding]; other site 693746004010 putative PBP binding regions; other site 693746004011 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693746004012 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693746004013 Walker A/P-loop; other site 693746004014 ATP binding site [chemical binding]; other site 693746004015 Q-loop/lid; other site 693746004016 ABC transporter signature motif; other site 693746004017 Walker B; other site 693746004018 D-loop; other site 693746004019 H-loop/switch region; other site 693746004020 YodA lipocalin-like domain; Region: YodA; cl01365 693746004021 S-layer homology domain; Region: SLH; pfam00395 693746004022 S-layer homology domain; Region: SLH; pfam00395 693746004023 H+ Antiporter protein; Region: 2A0121; TIGR00900 693746004024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746004025 putative substrate translocation pore; other site 693746004026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746004027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746004028 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746004029 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746004030 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 693746004031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746004032 flavodoxin; Provisional; Region: PRK06242 693746004033 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746004034 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746004035 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746004036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746004037 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693746004038 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693746004039 active site 693746004040 metal binding site [ion binding]; metal-binding site 693746004041 YibE/F-like protein; Region: YibE_F; cl02259 693746004042 YibE/F-like protein; Region: YibE_F; pfam07907 693746004043 YibE/F-like protein; Region: YibE_F; pfam07907 693746004044 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 693746004045 YibE/F-like protein; Region: YibE_F; pfam07907 693746004046 YibE/F-like protein; Region: YibE_F; pfam07907 693746004047 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 693746004048 Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]; Region: COG5124 693746004049 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746004050 Vomeronasal organ pheromone receptor family, V1R; Region: V1R; pfam03402 693746004051 Alpha helical coiled-coil rod protein (HCR); Region: HCR; pfam07111 693746004052 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746004053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746004054 Walker A/P-loop; other site 693746004055 ATP binding site [chemical binding]; other site 693746004056 Q-loop/lid; other site 693746004057 ABC transporter signature motif; other site 693746004058 Walker B; other site 693746004059 D-loop; other site 693746004060 H-loop/switch region; other site 693746004061 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 693746004062 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746004063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746004064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746004065 DNA binding residues [nucleotide binding] 693746004066 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746004067 RNA polymerase sigma factor; Provisional; Region: PRK11924 693746004068 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746004069 DNA binding residues [nucleotide binding] 693746004070 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746004071 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746004072 catalytic residues [active] 693746004073 catalytic nucleophile [active] 693746004074 Recombinase; Region: Recombinase; pfam07508 693746004075 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746004076 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 693746004077 putative active site [active] 693746004078 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 693746004079 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 693746004080 cell division protein FtsZ; Validated; Region: PRK09330 693746004081 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 693746004082 nucleotide binding site [chemical binding]; other site 693746004083 SulA interaction site; other site 693746004084 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693746004085 protein binding site [polypeptide binding]; other site 693746004086 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 693746004087 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 693746004088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004089 active site 693746004090 phosphorylation site [posttranslational modification] 693746004091 intermolecular recognition site; other site 693746004092 dimerization interface [polypeptide binding]; other site 693746004093 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 693746004094 TSCPD domain; Region: TSCPD; cl14834 693746004095 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 693746004096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746004097 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693746004098 motif II; other site 693746004099 elongation factor P; Validated; Region: PRK00529 693746004100 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 693746004101 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 693746004102 RNA binding site [nucleotide binding]; other site 693746004103 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 693746004104 RNA binding site [nucleotide binding]; other site 693746004105 Transcription initiation factor IIE; Region: TFIIE; smart00531 693746004106 SpoVA protein; Region: SpoVA; cl04298 693746004107 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 693746004108 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 693746004109 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 693746004110 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 693746004111 putative ATP binding site [chemical binding]; other site 693746004112 putative substrate interface [chemical binding]; other site 693746004113 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 693746004114 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 693746004115 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 693746004116 Chemoreceptor zinc-binding domain; Region: CZB; pfam13682 693746004117 CheW-like domain; Region: CheW; pfam01584 693746004118 YcxB-like protein; Region: YcxB; pfam14317 693746004119 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 693746004120 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 693746004121 active site 693746004122 HIGH motif; other site 693746004123 KMSKS motif; other site 693746004124 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 693746004125 tRNA binding surface [nucleotide binding]; other site 693746004126 anticodon binding site; other site 693746004127 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 693746004128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746004129 DNA polymerase IV; Reviewed; Region: PRK03103 693746004130 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 693746004131 active site 693746004132 DNA binding site [nucleotide binding] 693746004133 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 693746004134 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693746004135 dimer interface [polypeptide binding]; other site 693746004136 active site 693746004137 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693746004138 folate binding site [chemical binding]; other site 693746004139 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 693746004140 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 693746004141 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 693746004142 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 693746004143 Na binding site [ion binding]; other site 693746004144 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 693746004145 dimer interface [polypeptide binding]; other site 693746004146 substrate binding site [chemical binding]; other site 693746004147 ATP binding site [chemical binding]; other site 693746004148 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693746004149 thiamine phosphate binding site [chemical binding]; other site 693746004150 active site 693746004151 pyrophosphate binding site [ion binding]; other site 693746004152 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 693746004153 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 693746004154 substrate binding site [chemical binding]; other site 693746004155 multimerization interface [polypeptide binding]; other site 693746004156 ATP binding site [chemical binding]; other site 693746004157 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 693746004158 Subtilase family; Region: Peptidase_S8; pfam00082 693746004159 catalytic triad [active] 693746004160 putative active site [active] 693746004161 large tegument protein UL36; Provisional; Region: PHA03247 693746004162 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 693746004163 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746004164 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693746004165 catalytic residues [active] 693746004166 catalytic nucleophile [active] 693746004167 Presynaptic Site I dimer interface [polypeptide binding]; other site 693746004168 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693746004169 Synaptic Flat tetramer interface [polypeptide binding]; other site 693746004170 Synaptic Site I dimer interface [polypeptide binding]; other site 693746004171 DNA binding site [nucleotide binding] 693746004172 Recombinase; Region: Recombinase; pfam07508 693746004173 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746004174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746004175 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 693746004176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 693746004177 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746004178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746004179 Walker A motif; other site 693746004180 ATP binding site [chemical binding]; other site 693746004181 Walker B motif; other site 693746004182 arginine finger; other site 693746004183 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693746004184 putative catalytic cysteine [active] 693746004185 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746004186 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746004187 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746004188 dimerization interface [polypeptide binding]; other site 693746004189 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 693746004190 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693746004191 PYR/PP interface [polypeptide binding]; other site 693746004192 dimer interface [polypeptide binding]; other site 693746004193 TPP binding site [chemical binding]; other site 693746004194 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693746004195 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 693746004196 TPP-binding site [chemical binding]; other site 693746004197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746004198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746004199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746004200 dimerization interface [polypeptide binding]; other site 693746004201 EamA-like transporter family; Region: EamA; pfam00892 693746004202 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 693746004203 EamA-like transporter family; Region: EamA; pfam00892 693746004204 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 693746004205 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693746004206 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693746004207 NAD(P) binding pocket [chemical binding]; other site 693746004208 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693746004209 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693746004210 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 693746004211 active site 693746004212 catalytic residues [active] 693746004213 metal binding site [ion binding]; metal-binding site 693746004214 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746004215 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746004216 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693746004217 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 693746004218 active site 693746004219 NodB motif; other site 693746004220 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693746004221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746004222 dimerization interface [polypeptide binding]; other site 693746004223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746004224 dimer interface [polypeptide binding]; other site 693746004225 putative CheW interface [polypeptide binding]; other site 693746004226 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693746004227 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746004228 Zn2+ binding site [ion binding]; other site 693746004229 Mg2+ binding site [ion binding]; other site 693746004230 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746004231 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746004232 catalytic residues [active] 693746004233 catalytic nucleophile [active] 693746004234 Recombinase; Region: Recombinase; pfam07508 693746004235 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746004236 Bacterial SH3 domain; Region: SH3_3; pfam08239 693746004237 Bacterial SH3 domain; Region: SH3_3; pfam08239 693746004238 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693746004239 NlpC/P60 family; Region: NLPC_P60; pfam00877 693746004240 Predicted transcriptional regulator [Transcription]; Region: COG1959 693746004241 Rrf2 family protein; Region: rrf2_super; TIGR00738 693746004242 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746004243 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693746004244 FAD binding site [chemical binding]; other site 693746004245 homotetramer interface [polypeptide binding]; other site 693746004246 substrate binding pocket [chemical binding]; other site 693746004247 catalytic base [active] 693746004248 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693746004249 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693746004250 Rubredoxin [Energy production and conversion]; Region: COG1773 693746004251 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 693746004252 iron binding site [ion binding]; other site 693746004253 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 693746004254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746004255 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746004256 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693746004257 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693746004258 active site 693746004259 metal binding site [ion binding]; metal-binding site 693746004260 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746004261 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746004262 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746004263 Integrase core domain; Region: rve; pfam00665 693746004264 Integrase core domain; Region: rve_2; pfam13333 693746004265 HTH-like domain; Region: HTH_21; pfam13276 693746004266 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746004267 EamA-like transporter family; Region: EamA; pfam00892 693746004268 EamA-like transporter family; Region: EamA; pfam00892 693746004269 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 693746004270 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 693746004271 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 693746004272 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 693746004273 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 693746004274 23S rRNA binding site [nucleotide binding]; other site 693746004275 L21 binding site [polypeptide binding]; other site 693746004276 L13 binding site [polypeptide binding]; other site 693746004277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746004278 S-adenosylmethionine binding site [chemical binding]; other site 693746004279 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 693746004280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693746004281 substrate binding site [chemical binding]; other site 693746004282 oxyanion hole (OAH) forming residues; other site 693746004283 trimer interface [polypeptide binding]; other site 693746004284 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 693746004285 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693746004286 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693746004287 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746004288 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693746004289 FAD binding site [chemical binding]; other site 693746004290 homotetramer interface [polypeptide binding]; other site 693746004291 substrate binding pocket [chemical binding]; other site 693746004292 catalytic base [active] 693746004293 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693746004294 Ligand binding site [chemical binding]; other site 693746004295 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693746004296 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693746004297 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693746004298 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 693746004299 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 693746004300 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 693746004301 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 693746004302 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 693746004303 homodimer interface [polypeptide binding]; other site 693746004304 NADP binding site [chemical binding]; other site 693746004305 substrate binding site [chemical binding]; other site 693746004306 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 693746004307 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 693746004308 Potassium binding sites [ion binding]; other site 693746004309 Cesium cation binding sites [ion binding]; other site 693746004310 Cupin domain; Region: Cupin_2; pfam07883 693746004311 Histidine kinase; Region: His_kinase; pfam06580 693746004312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004313 active site 693746004314 phosphorylation site [posttranslational modification] 693746004315 intermolecular recognition site; other site 693746004316 dimerization interface [polypeptide binding]; other site 693746004317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746004318 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746004319 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 693746004320 dimer interface [polypeptide binding]; other site 693746004321 active site 693746004322 glycine-pyridoxal phosphate binding site [chemical binding]; other site 693746004323 folate binding site [chemical binding]; other site 693746004324 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 693746004325 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746004326 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 693746004327 metal binding site [ion binding]; metal-binding site 693746004328 dimer interface [polypeptide binding]; other site 693746004329 potential frameshift: common BLAST hit: gi|219683956|ref|YP_002470339.1| transposase, IS4 693746004330 Transposase domain (DUF772); Region: DUF772; pfam05598 693746004331 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746004332 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746004333 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 693746004334 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 693746004335 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 693746004336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004337 active site 693746004338 phosphorylation site [posttranslational modification] 693746004339 intermolecular recognition site; other site 693746004340 dimerization interface [polypeptide binding]; other site 693746004341 YcbB domain; Region: YcbB; pfam08664 693746004342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746004343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746004344 ATP binding site [chemical binding]; other site 693746004345 Mg2+ binding site [ion binding]; other site 693746004346 G-X-G motif; other site 693746004347 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 693746004348 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 693746004349 NAD binding site [chemical binding]; other site 693746004350 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 693746004351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746004352 Transposase; Region: HTH_Tnp_1; cl17663 693746004353 HTH-like domain; Region: HTH_21; pfam13276 693746004354 Integrase core domain; Region: rve; pfam00665 693746004355 Integrase core domain; Region: rve_2; pfam13333 693746004356 Integrase core domain; Region: rve; pfam00665 693746004357 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 693746004358 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693746004359 putative catalytic cysteine [active] 693746004360 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693746004361 active site 693746004362 NAD binding site [chemical binding]; other site 693746004363 metal binding site [ion binding]; metal-binding site 693746004364 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693746004365 active site 693746004366 NAD binding site [chemical binding]; other site 693746004367 Sensory domain found in PocR; Region: PocR; pfam10114 693746004368 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746004369 dimer interface [polypeptide binding]; other site 693746004370 putative CheW interface [polypeptide binding]; other site 693746004371 putative transposase OrfB; Reviewed; Region: PHA02517 693746004372 HTH-like domain; Region: HTH_21; pfam13276 693746004373 Integrase core domain; Region: rve; pfam00665 693746004374 Integrase core domain; Region: rve_3; cl15866 693746004375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746004376 Transposase; Region: HTH_Tnp_1; cl17663 693746004377 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 693746004378 catalytic triad [active] 693746004379 conserved cis-peptide bond; other site 693746004380 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746004381 catalytic loop [active] 693746004382 iron binding site [ion binding]; other site 693746004383 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693746004384 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 693746004385 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693746004386 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 693746004387 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 693746004388 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 693746004389 dimer interface [polypeptide binding]; other site 693746004390 [2Fe-2S] cluster binding site [ion binding]; other site 693746004391 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 693746004392 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 693746004393 SLBB domain; Region: SLBB; pfam10531 693746004394 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 693746004395 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693746004396 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746004397 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 693746004398 Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cd00086 693746004399 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 693746004400 putative dimer interface [polypeptide binding]; other site 693746004401 [2Fe-2S] cluster binding site [ion binding]; other site 693746004402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746004403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746004404 ATP binding site [chemical binding]; other site 693746004405 Mg2+ binding site [ion binding]; other site 693746004406 G-X-G motif; other site 693746004407 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693746004408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004409 active site 693746004410 phosphorylation site [posttranslational modification] 693746004411 intermolecular recognition site; other site 693746004412 dimerization interface [polypeptide binding]; other site 693746004413 YcbB domain; Region: YcbB; pfam08664 693746004414 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 693746004415 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746004416 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746004417 Walker A/P-loop; other site 693746004418 ATP binding site [chemical binding]; other site 693746004419 Q-loop/lid; other site 693746004420 ABC transporter signature motif; other site 693746004421 Walker B; other site 693746004422 D-loop; other site 693746004423 H-loop/switch region; other site 693746004424 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693746004425 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746004426 FtsX-like permease family; Region: FtsX; pfam02687 693746004427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693746004428 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 693746004429 FtsX-like permease family; Region: FtsX; pfam02687 693746004430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746004431 Transposase; Region: HTH_Tnp_1; cl17663 693746004432 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746004433 HTH-like domain; Region: HTH_21; pfam13276 693746004434 Integrase core domain; Region: rve; pfam00665 693746004435 Integrase core domain; Region: rve_3; cl15866 693746004436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746004437 active site 693746004438 DNA binding site [nucleotide binding] 693746004439 Int/Topo IB signature motif; other site 693746004440 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746004441 HTH-like domain; Region: HTH_21; pfam13276 693746004442 Integrase core domain; Region: rve; pfam00665 693746004443 Integrase core domain; Region: rve_3; pfam13683 693746004444 Transposase; Region: HTH_Tnp_1; pfam01527 693746004445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746004446 Transposase; Region: HTH_Tnp_1; cl17663 693746004447 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746004448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004449 active site 693746004450 phosphorylation site [posttranslational modification] 693746004451 intermolecular recognition site; other site 693746004452 dimerization interface [polypeptide binding]; other site 693746004453 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746004454 DNA binding site [nucleotide binding] 693746004455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746004456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746004457 dimer interface [polypeptide binding]; other site 693746004458 phosphorylation site [posttranslational modification] 693746004459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746004460 ATP binding site [chemical binding]; other site 693746004461 Mg2+ binding site [ion binding]; other site 693746004462 G-X-G motif; other site 693746004463 Beta-lactamase; Region: Beta-lactamase; cl17358 693746004464 potential frameshift: common BLAST hit: gi|300857009|ref|YP_003781993.1| putative penicillin-binding protein 693746004465 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693746004466 Beta-lactamase; Region: Beta-lactamase; pfam00144 693746004467 putative transposase OrfB; Reviewed; Region: PHA02517 693746004468 Integrase core domain; Region: rve; pfam00665 693746004469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746004470 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 693746004471 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 693746004472 5S rRNA interface [nucleotide binding]; other site 693746004473 CTC domain interface [polypeptide binding]; other site 693746004474 L16 interface [polypeptide binding]; other site 693746004475 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 693746004476 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 693746004477 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693746004478 HAMP domain; Region: HAMP; pfam00672 693746004479 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746004480 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746004481 dimer interface [polypeptide binding]; other site 693746004482 putative CheW interface [polypeptide binding]; other site 693746004483 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746004484 Integrase core domain; Region: rve; pfam00665 693746004485 Integrase core domain; Region: rve_3; cl15866 693746004486 HTH-like domain; Region: HTH_21; pfam13276 693746004487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746004488 Transposase; Region: HTH_Tnp_1; cl17663 693746004489 S-layer homology domain; Region: SLH; pfam00395 693746004490 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693746004491 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 693746004492 NodB motif; other site 693746004493 active site 693746004494 catalytic site [active] 693746004495 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746004496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746004497 Transposase; Region: HTH_Tnp_1; pfam01527 693746004498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746004499 HTH-like domain; Region: HTH_21; pfam13276 693746004500 Integrase core domain; Region: rve; pfam00665 693746004501 Integrase core domain; Region: rve_3; pfam13683 693746004502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746004503 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746004504 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 693746004505 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746004506 Sel1-like repeats; Region: SEL1; smart00671 693746004507 Sel1-like repeats; Region: SEL1; smart00671 693746004508 Sel1-like repeats; Region: SEL1; smart00671 693746004509 Sel1-like repeats; Region: SEL1; smart00671 693746004510 Sel1-like repeats; Region: SEL1; smart00671 693746004511 Sel1-like repeats; Region: SEL1; smart00671 693746004512 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746004513 Sel1-like repeats; Region: SEL1; smart00671 693746004514 Sel1-like repeats; Region: SEL1; smart00671 693746004515 Sel1-like repeats; Region: SEL1; smart00671 693746004516 Sel1-like repeats; Region: SEL1; smart00671 693746004517 Sel1-like repeats; Region: SEL1; smart00671 693746004518 Sel1-like repeats; Region: SEL1; smart00671 693746004519 Sel1-like repeats; Region: SEL1; smart00671 693746004520 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746004521 Sel1-like repeats; Region: SEL1; smart00671 693746004522 Sel1-like repeats; Region: SEL1; smart00671 693746004523 Sel1-like repeats; Region: SEL1; smart00671 693746004524 Sel1-like repeats; Region: SEL1; smart00671 693746004525 Sel1-like repeats; Region: SEL1; smart00671 693746004526 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746004527 Sel1-like repeats; Region: SEL1; smart00671 693746004528 Sel1-like repeats; Region: SEL1; smart00671 693746004529 Sel1 repeat; Region: Sel1; pfam08238 693746004530 Sel1-like repeats; Region: SEL1; smart00671 693746004531 Sel1-like repeats; Region: SEL1; smart00671 693746004532 Sel1-like repeats; Region: SEL1; smart00671 693746004533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 693746004534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746004535 Coenzyme A binding pocket [chemical binding]; other site 693746004536 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746004537 HTH-like domain; Region: HTH_21; pfam13276 693746004538 Integrase core domain; Region: rve; pfam00665 693746004539 Integrase core domain; Region: rve_3; pfam13683 693746004540 Transposase; Region: HTH_Tnp_1; pfam01527 693746004541 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746004542 Integrase core domain; Region: rve; pfam00665 693746004543 Integrase core domain; Region: rve_3; pfam13683 693746004544 CAAX protease self-immunity; Region: Abi; pfam02517 693746004545 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 693746004546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746004547 active site 693746004548 DNA binding site [nucleotide binding] 693746004549 Int/Topo IB signature motif; other site 693746004550 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746004551 Putative transposase; Region: Y2_Tnp; pfam04986 693746004552 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 693746004553 Thiamine pyrophosphokinase; Region: TPK; cd07995 693746004554 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 693746004555 active site 693746004556 dimerization interface [polypeptide binding]; other site 693746004557 thiamine binding site [chemical binding]; other site 693746004558 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746004559 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 693746004560 catalytic loop [active] 693746004561 iron binding site [ion binding]; other site 693746004562 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693746004563 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746004564 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746004565 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 693746004566 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 693746004567 Ligand binding site; other site 693746004568 metal-binding site 693746004569 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 693746004570 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746004571 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746004572 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 693746004573 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 693746004574 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 693746004575 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693746004576 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746004577 catalytic loop [active] 693746004578 iron binding site [ion binding]; other site 693746004579 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693746004580 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 693746004581 AAA domain; Region: AAA_18; pfam13238 693746004582 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 693746004583 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693746004584 metal-binding site [ion binding] 693746004585 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 693746004586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746004587 motif II; other site 693746004588 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 693746004589 putative homodimer interface [polypeptide binding]; other site 693746004590 putative homotetramer interface [polypeptide binding]; other site 693746004591 putative allosteric switch controlling residues; other site 693746004592 putative metal binding site [ion binding]; other site 693746004593 putative homodimer-homodimer interface [polypeptide binding]; other site 693746004594 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 693746004595 metal-binding site [ion binding] 693746004596 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 693746004597 G5 domain; Region: G5; pfam07501 693746004598 3D domain; Region: 3D; cl01439 693746004599 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 693746004600 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 693746004601 NodB motif; other site 693746004602 active site 693746004603 catalytic site [active] 693746004604 Zn binding site [ion binding]; other site 693746004605 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 693746004606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746004607 S-adenosylmethionine binding site [chemical binding]; other site 693746004608 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 693746004609 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 693746004610 active site 693746004611 catalytic tetrad [active] 693746004612 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693746004613 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 693746004614 Transcriptional regulator PadR-like family; Region: PadR; cl17335 693746004615 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 693746004616 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693746004617 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746004618 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746004619 catalytic residues [active] 693746004620 catalytic nucleophile [active] 693746004621 Recombinase; Region: Recombinase; pfam07508 693746004622 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746004623 Cache domain; Region: Cache_1; pfam02743 693746004624 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 693746004625 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746004626 dimerization interface [polypeptide binding]; other site 693746004627 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746004628 dimer interface [polypeptide binding]; other site 693746004629 putative CheW interface [polypeptide binding]; other site 693746004630 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693746004631 active site 693746004632 NAD binding site [chemical binding]; other site 693746004633 metal binding site [ion binding]; metal-binding site 693746004634 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 693746004635 SLBB domain; Region: SLBB; pfam10531 693746004636 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693746004637 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 693746004638 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 693746004639 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 693746004640 putative hexamer interface [polypeptide binding]; other site 693746004641 putative hexagonal pore; other site 693746004642 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 693746004643 putative hexamer interface [polypeptide binding]; other site 693746004644 putative hexagonal pore; other site 693746004645 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 693746004646 intracellular protease, PfpI family; Region: PfpI; TIGR01382 693746004647 conserved cys residue [active] 693746004648 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 693746004649 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 693746004650 dimer interface [polypeptide binding]; other site 693746004651 active site 693746004652 glycine loop; other site 693746004653 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 693746004654 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693746004655 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 693746004656 propanediol utilization protein PduB; Provisional; Region: PRK15415 693746004657 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 693746004658 putative hexamer interface [polypeptide binding]; other site 693746004659 putative hexagonal pore; other site 693746004660 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 693746004661 putative hexamer interface [polypeptide binding]; other site 693746004662 putative hexagonal pore; other site 693746004663 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 693746004664 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 693746004665 Hexamer interface [polypeptide binding]; other site 693746004666 Hexagonal pore residue; other site 693746004667 Sensory domain found in PocR; Region: PocR; pfam10114 693746004668 Histidine kinase; Region: His_kinase; pfam06580 693746004669 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 693746004670 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 693746004671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004672 active site 693746004673 phosphorylation site [posttranslational modification] 693746004674 intermolecular recognition site; other site 693746004675 dimerization interface [polypeptide binding]; other site 693746004676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746004677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746004678 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693746004679 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693746004680 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693746004681 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693746004682 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 693746004683 putative catalytic cysteine [active] 693746004684 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 693746004685 Hexamer interface [polypeptide binding]; other site 693746004686 Hexagonal pore residue; other site 693746004687 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 693746004688 Propanediol utilisation protein PduL; Region: PduL; pfam06130 693746004689 Propanediol utilisation protein PduL; Region: PduL; pfam06130 693746004690 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 693746004691 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693746004692 nucleotide binding site [chemical binding]; other site 693746004693 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746004694 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 693746004695 Hexamer/Pentamer interface [polypeptide binding]; other site 693746004696 central pore; other site 693746004697 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 693746004698 putative hexamer interface [polypeptide binding]; other site 693746004699 putative hexagonal pore; other site 693746004700 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 693746004701 G1 box; other site 693746004702 GTP/Mg2+ binding site [chemical binding]; other site 693746004703 G2 box; other site 693746004704 Switch I region; other site 693746004705 G3 box; other site 693746004706 Switch II region; other site 693746004707 G4 box; other site 693746004708 G5 box; other site 693746004709 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 693746004710 Hexamer interface [polypeptide binding]; other site 693746004711 Hexagonal pore residue; other site 693746004712 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746004713 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746004714 catalytic residues [active] 693746004715 catalytic nucleophile [active] 693746004716 Recombinase; Region: Recombinase; pfam07508 693746004717 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746004718 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746004719 Translocon-associated protein, gamma subunit (TRAP-gamma); Region: TRAP-gamma; pfam07074 693746004720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746004721 metal binding site [ion binding]; metal-binding site 693746004722 active site 693746004723 I-site; other site 693746004724 Integrase core domain; Region: rve_3; cl15866 693746004725 potential frameshift: common BLAST hit: gi|308069337|ref|YP_003870942.1| transposase-like protein 693746004726 Integrase core domain; Region: rve; pfam00665 693746004727 putative transposase OrfB; Reviewed; Region: PHA02517 693746004728 CoA binding domain; Region: CoA_binding_2; pfam13380 693746004729 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 693746004730 catalytic triad [active] 693746004731 conserved cis-peptide bond; other site 693746004732 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 693746004733 dimerization interface [polypeptide binding]; other site 693746004734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746004735 dimerization interface [polypeptide binding]; other site 693746004736 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746004737 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746004738 dimer interface [polypeptide binding]; other site 693746004739 putative CheW interface [polypeptide binding]; other site 693746004740 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004744 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004747 Peptidase family S41; Region: Peptidase_S41; cl19216 693746004748 Predicted membrane protein [Function unknown]; Region: COG2261 693746004749 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 693746004750 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 693746004751 active site 693746004752 NTP binding site [chemical binding]; other site 693746004753 metal binding triad [ion binding]; metal-binding site 693746004754 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 693746004755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746004756 Zn2+ binding site [ion binding]; other site 693746004757 Mg2+ binding site [ion binding]; other site 693746004758 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 693746004759 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693746004760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746004761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693746004762 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 693746004763 putative deacylase active site [active] 693746004764 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 693746004765 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 693746004766 DNA primase, catalytic core; Region: dnaG; TIGR01391 693746004767 CHC2 zinc finger; Region: zf-CHC2; pfam01807 693746004768 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 693746004769 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 693746004770 active site 693746004771 metal binding site [ion binding]; metal-binding site 693746004772 interdomain interaction site; other site 693746004773 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 693746004774 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 693746004775 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 693746004776 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746004777 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693746004778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746004779 DNA binding residues [nucleotide binding] 693746004780 potential frameshift: common BLAST hit: gi|347533384|ref|YP_004840147.1| transposase mutator type 693746004781 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746004782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746004783 potential frameshift: common BLAST hit: gi|347533384|ref|YP_004840147.1| transposase mutator type 693746004784 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746004785 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746004786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746004787 transposase/IS protein; Provisional; Region: PRK09183 693746004788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693746004789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746004790 Walker A motif; other site 693746004791 ATP binding site [chemical binding]; other site 693746004792 Walker B motif; other site 693746004793 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746004794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746004795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746004796 Integrase core domain; Region: rve; pfam00665 693746004797 Transposase; Region: HTH_Tnp_1; cl17663 693746004798 Phage terminase large subunit; Region: Terminase_3; cl12054 693746004799 Terminase-like family; Region: Terminase_6; pfam03237 693746004800 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531 693746004801 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 693746004802 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693746004803 C2H2 type zinc-finger (2 copies); Region: zf-C2H2_2; pfam12756 693746004804 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 693746004805 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 693746004806 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693746004807 NlpC/P60 family; Region: NLPC_P60; cl17555 693746004808 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 693746004809 Putative amidase domain; Region: Amidase_6; pfam12671 693746004810 Small acid-soluble spore protein H family; Region: SspH; pfam08141 693746004811 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 693746004812 classical (c) SDRs; Region: SDR_c; cd05233 693746004813 NAD(P) binding site [chemical binding]; other site 693746004814 active site 693746004815 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 693746004816 active site 693746004817 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 693746004818 SmpB-tmRNA interface; other site 693746004819 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 693746004820 dimer interface [polypeptide binding]; other site 693746004821 ADP-ribose binding site [chemical binding]; other site 693746004822 active site 693746004823 nudix motif; other site 693746004824 metal binding site [ion binding]; metal-binding site 693746004825 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746004826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004827 active site 693746004828 phosphorylation site [posttranslational modification] 693746004829 intermolecular recognition site; other site 693746004830 dimerization interface [polypeptide binding]; other site 693746004831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746004832 DNA binding site [nucleotide binding] 693746004833 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 693746004834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746004835 dimerization interface [polypeptide binding]; other site 693746004836 PAS domain; Region: PAS; smart00091 693746004837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746004838 dimer interface [polypeptide binding]; other site 693746004839 phosphorylation site [posttranslational modification] 693746004840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746004841 ATP binding site [chemical binding]; other site 693746004842 Mg2+ binding site [ion binding]; other site 693746004843 G-X-G motif; other site 693746004844 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 693746004845 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 693746004846 hinge; other site 693746004847 active site 693746004848 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 693746004849 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 693746004850 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 693746004851 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 693746004852 active site 693746004853 substrate binding site [chemical binding]; other site 693746004854 metal binding site [ion binding]; metal-binding site 693746004855 Transposase; Region: HTH_Tnp_1; cl17663 693746004856 putative transposase OrfB; Reviewed; Region: PHA02517 693746004857 Integrase core domain; Region: rve; pfam00665 693746004858 Integrase core domain; Region: rve_3; cl15866 693746004859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746004860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746004861 dimer interface [polypeptide binding]; other site 693746004862 phosphorylation site [posttranslational modification] 693746004863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746004864 ATP binding site [chemical binding]; other site 693746004865 Mg2+ binding site [ion binding]; other site 693746004866 G-X-G motif; other site 693746004867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746004868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746004869 active site 693746004870 phosphorylation site [posttranslational modification] 693746004871 intermolecular recognition site; other site 693746004872 dimerization interface [polypeptide binding]; other site 693746004873 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746004874 DNA binding site [nucleotide binding] 693746004875 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746004876 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746004877 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746004878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746004879 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 693746004880 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 693746004881 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 693746004882 dimer interface [polypeptide binding]; other site 693746004883 putative functional site; other site 693746004884 putative MPT binding site; other site 693746004885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746004886 S-adenosylmethionine binding site [chemical binding]; other site 693746004887 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 693746004888 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 693746004889 Walker A/P-loop; other site 693746004890 ATP binding site [chemical binding]; other site 693746004891 Q-loop/lid; other site 693746004892 ABC transporter signature motif; other site 693746004893 Walker B; other site 693746004894 D-loop; other site 693746004895 H-loop/switch region; other site 693746004896 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 693746004897 ABC-ATPase subunit interface; other site 693746004898 dimer interface [polypeptide binding]; other site 693746004899 putative PBP binding regions; other site 693746004900 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693746004901 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 693746004902 intersubunit interface [polypeptide binding]; other site 693746004903 biotin synthase; Region: bioB; TIGR00433 693746004904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746004905 FeS/SAM binding site; other site 693746004906 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746004907 NTPase; Region: NTPase_1; cl17478 693746004908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004910 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693746004911 active site 693746004912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746004913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746004914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746004915 dimerization interface [polypeptide binding]; other site 693746004916 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 693746004917 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 693746004918 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 693746004919 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 693746004920 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 693746004921 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 693746004922 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 693746004923 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 693746004924 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693746004925 hydrogenase 4 subunit F; Validated; Region: PRK06458 693746004926 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693746004927 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 693746004928 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 693746004929 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693746004930 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 693746004931 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 693746004932 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 693746004933 Phage terminase large subunit; Region: Terminase_3; cl12054 693746004934 Terminase-like family; Region: Terminase_6; pfam03237 693746004935 Phage portal protein; Region: Phage_portal; cl19194 693746004936 Phage capsid family; Region: Phage_capsid; cl19393 693746004937 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 693746004938 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 693746004939 DNA circularisation protein N-terminus; Region: DNA_circ_N; cl19561 693746004940 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 693746004941 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746004942 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 693746004943 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 693746004944 hypothetical protein; Region: PHA02414 693746004945 TIGR02594 family protein; Region: TIGR02594 693746004946 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746004947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746004948 non-specific DNA binding site [nucleotide binding]; other site 693746004949 salt bridge; other site 693746004950 sequence-specific DNA binding site [nucleotide binding]; other site 693746004951 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 693746004952 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 693746004953 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 693746004954 hypothetical protein; Provisional; Region: PRK05473 693746004955 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 693746004956 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 693746004957 putative tRNA-binding site [nucleotide binding]; other site 693746004958 B3/4 domain; Region: B3_4; pfam03483 693746004959 tRNA synthetase B5 domain; Region: B5; smart00874 693746004960 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 693746004961 dimer interface [polypeptide binding]; other site 693746004962 motif 1; other site 693746004963 motif 3; other site 693746004964 motif 2; other site 693746004965 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 693746004966 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 693746004967 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 693746004968 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 693746004969 dimer interface [polypeptide binding]; other site 693746004970 motif 1; other site 693746004971 active site 693746004972 motif 2; other site 693746004973 motif 3; other site 693746004974 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 693746004975 putative substrate binding site [chemical binding]; other site 693746004976 putative ATP binding site [chemical binding]; other site 693746004977 alanine racemase; Reviewed; Region: alr; PRK00053 693746004978 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 693746004979 active site 693746004980 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693746004981 dimer interface [polypeptide binding]; other site 693746004982 substrate binding site [chemical binding]; other site 693746004983 catalytic residues [active] 693746004984 PemK-like protein; Region: PemK; pfam02452 693746004985 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 693746004986 ATP cone domain; Region: ATP-cone; pfam03477 693746004987 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746004988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746004989 non-specific DNA binding site [nucleotide binding]; other site 693746004990 salt bridge; other site 693746004991 sequence-specific DNA binding site [nucleotide binding]; other site 693746004992 Protein of unknown function (DUF2675); Region: DUF2675; pfam11247 693746004993 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746004994 putative DNA binding site [nucleotide binding]; other site 693746004995 putative Zn2+ binding site [ion binding]; other site 693746004996 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 693746004997 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 693746004998 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 693746004999 Catalytic site [active] 693746005000 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 693746005001 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 693746005002 GTP/Mg2+ binding site [chemical binding]; other site 693746005003 G4 box; other site 693746005004 G5 box; other site 693746005005 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 693746005006 G1 box; other site 693746005007 G1 box; other site 693746005008 GTP/Mg2+ binding site [chemical binding]; other site 693746005009 Switch I region; other site 693746005010 G2 box; other site 693746005011 G2 box; other site 693746005012 G3 box; other site 693746005013 G3 box; other site 693746005014 Switch II region; other site 693746005015 Switch II region; other site 693746005016 G4 box; other site 693746005017 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 693746005018 RNA/DNA hybrid binding site [nucleotide binding]; other site 693746005019 active site 693746005020 hypothetical protein; Reviewed; Region: PRK12497 693746005021 threonine synthase; Validated; Region: PRK09225 693746005022 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 693746005023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746005024 catalytic residue [active] 693746005025 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 693746005026 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693746005027 active site 693746005028 metal binding site [ion binding]; metal-binding site 693746005029 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 693746005030 trigger factor; Provisional; Region: tig; PRK01490 693746005031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 693746005032 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 693746005033 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 693746005034 oligomer interface [polypeptide binding]; other site 693746005035 active site residues [active] 693746005036 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 693746005037 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 693746005038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005039 Walker A motif; other site 693746005040 ATP binding site [chemical binding]; other site 693746005041 Walker B motif; other site 693746005042 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693746005043 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 693746005044 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 693746005045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005046 Walker A motif; other site 693746005047 ATP binding site [chemical binding]; other site 693746005048 Walker B motif; other site 693746005049 arginine finger; other site 693746005050 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693746005051 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 693746005052 Predicted GTPase [General function prediction only]; Region: COG0218 693746005053 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 693746005054 G1 box; other site 693746005055 GTP/Mg2+ binding site [chemical binding]; other site 693746005056 Switch I region; other site 693746005057 G2 box; other site 693746005058 G3 box; other site 693746005059 Switch II region; other site 693746005060 G4 box; other site 693746005061 G5 box; other site 693746005062 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 693746005063 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 693746005064 putative nucleotide binding site [chemical binding]; other site 693746005065 uridine monophosphate binding site [chemical binding]; other site 693746005066 homohexameric interface [polypeptide binding]; other site 693746005067 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 693746005068 hinge region; other site 693746005069 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 693746005070 active site 693746005071 dimer interface [polypeptide binding]; other site 693746005072 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 693746005073 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 693746005074 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 693746005075 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 693746005076 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 693746005077 RIP metalloprotease RseP; Region: TIGR00054 693746005078 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 693746005079 active site 693746005080 putative substrate binding region [chemical binding]; other site 693746005081 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 693746005082 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 693746005083 DNA polymerase III, alpha chain, Gram-positive type; Region: polC_Gram_pos; TIGR01405 693746005084 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 693746005085 generic binding surface II; other site 693746005086 generic binding surface I; other site 693746005087 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 693746005088 active site 693746005089 putative PHP Thumb interface [polypeptide binding]; other site 693746005090 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160 693746005091 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 693746005092 Cation transport protein; Region: TrkH; cl17365 693746005093 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693746005094 Cation transport protein; Region: TrkH; pfam02386 693746005095 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 693746005096 TrkA-N domain; Region: TrkA_N; pfam02254 693746005097 TrkA-C domain; Region: TrkA_C; pfam02080 693746005098 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 693746005099 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693746005100 minor groove reading motif; other site 693746005101 helix-hairpin-helix signature motif; other site 693746005102 substrate binding pocket [chemical binding]; other site 693746005103 active site 693746005104 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 693746005105 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 693746005106 Predicted membrane protein [Function unknown]; Region: COG2323 693746005107 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 693746005108 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 693746005109 glutaminase active site [active] 693746005110 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 693746005111 dimer interface [polypeptide binding]; other site 693746005112 active site 693746005113 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 693746005114 dimer interface [polypeptide binding]; other site 693746005115 active site 693746005116 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746005117 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746005118 Integrase core domain; Region: rve; pfam00665 693746005119 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746005120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746005121 transposase/IS protein; Provisional; Region: PRK09183 693746005122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005123 Walker A motif; other site 693746005124 ATP binding site [chemical binding]; other site 693746005125 Walker B motif; other site 693746005126 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 693746005127 transposase/IS protein; Provisional; Region: PRK09183 693746005128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005129 Walker A motif; other site 693746005130 ATP binding site [chemical binding]; other site 693746005131 Walker B motif; other site 693746005132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746005133 Integrase core domain; Region: rve; pfam00665 693746005134 Transposase; Region: HTH_Tnp_1; pfam01527 693746005135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746005136 HTH-like domain; Region: HTH_21; pfam13276 693746005137 Integrase core domain; Region: rve; pfam00665 693746005138 Integrase core domain; Region: rve_3; pfam13683 693746005139 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 693746005140 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746005141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746005142 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746005143 Predicted permeases [General function prediction only]; Region: COG0679 693746005144 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 693746005145 Predicted membrane protein [Function unknown]; Region: COG1971 693746005146 Domain of unknown function DUF; Region: DUF204; pfam02659 693746005147 Domain of unknown function DUF; Region: DUF204; pfam02659 693746005148 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 693746005149 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693746005150 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693746005151 glutamate dehydrogenase; Provisional; Region: PRK09414 693746005152 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 693746005153 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 693746005154 NAD(P) binding pocket [chemical binding]; other site 693746005155 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746005156 active site 693746005157 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 693746005158 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746005159 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693746005160 active site 693746005161 catalytic residues [active] 693746005162 DNA binding site [nucleotide binding] 693746005163 Int/Topo IB signature motif; other site 693746005164 Uncharacterized conserved protein [Function unknown]; Region: COG4748 693746005165 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 693746005166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746005167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746005168 non-specific DNA binding site [nucleotide binding]; other site 693746005169 salt bridge; other site 693746005170 sequence-specific DNA binding site [nucleotide binding]; other site 693746005171 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746005172 non-specific DNA binding site [nucleotide binding]; other site 693746005173 salt bridge; other site 693746005174 sequence-specific DNA binding site [nucleotide binding]; other site 693746005175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746005176 salt bridge; other site 693746005177 non-specific DNA binding site [nucleotide binding]; other site 693746005178 sequence-specific DNA binding site [nucleotide binding]; other site 693746005179 RecF/RecN/SMC N terminal domain; Region: SMC_N; pfam02463 693746005180 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746005181 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 693746005182 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746005183 Walker A motif; other site 693746005184 ATP binding site [chemical binding]; other site 693746005185 Walker B motif; other site 693746005186 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746005187 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746005188 P-loop; other site 693746005189 Magnesium ion binding site [ion binding]; other site 693746005190 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 693746005191 ParB-like nuclease domain; Region: ParBc; pfam02195 693746005192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746005193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746005194 non-specific DNA binding site [nucleotide binding]; other site 693746005195 salt bridge; other site 693746005196 sequence-specific DNA binding site [nucleotide binding]; other site 693746005197 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 693746005198 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693746005199 dimer interface [polypeptide binding]; other site 693746005200 ssDNA binding site [nucleotide binding]; other site 693746005201 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693746005202 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 693746005203 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693746005204 active site 693746005205 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 693746005206 ParB-like nuclease domain; Region: ParBc; pfam02195 693746005207 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 693746005208 Phage terminase, small subunit; Region: Terminase_4; cl01525 693746005209 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 693746005210 Phage Terminase; Region: Terminase_1; cl19862 693746005211 Phage portal protein; Region: Phage_portal; pfam04860 693746005212 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 693746005213 oligomer interface [polypeptide binding]; other site 693746005214 active site residues [active] 693746005215 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 693746005216 Phage capsid family; Region: Phage_capsid; pfam05065 693746005217 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 693746005218 oligomerization interface [polypeptide binding]; other site 693746005219 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 693746005220 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 693746005221 Phage XkdN-like protein; Region: XkdN; pfam08890 693746005222 tape measure domain; Region: tape_meas_nterm; TIGR02675 693746005223 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746005224 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 693746005225 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 693746005226 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 693746005227 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 693746005228 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 693746005229 aromatic chitin/cellulose binding site residues [chemical binding]; other site 693746005230 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 693746005231 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746005232 Holin family; Region: Phage_holin_4; cl01989 693746005233 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 693746005234 catalytic residue [active] 693746005235 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693746005236 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 693746005237 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 693746005238 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 693746005239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 693746005240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746005241 metal binding site [ion binding]; metal-binding site 693746005242 active site 693746005243 I-site; other site 693746005244 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746005245 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746005246 catalytic residue [active] 693746005247 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746005248 EamA-like transporter family; Region: EamA; pfam00892 693746005249 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 693746005250 putative ADP-ribose binding site [chemical binding]; other site 693746005251 putative active site [active] 693746005252 Class I aldolases; Region: Aldolase_Class_I; cl17187 693746005253 catalytic residue [active] 693746005254 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 693746005255 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 693746005256 active site 693746005257 putative substrate binding pocket [chemical binding]; other site 693746005258 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 693746005259 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693746005260 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 693746005261 putative L-serine binding site [chemical binding]; other site 693746005262 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 693746005263 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 693746005264 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693746005265 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693746005266 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746005267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746005268 ATP binding site [chemical binding]; other site 693746005269 putative Mg++ binding site [ion binding]; other site 693746005270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746005271 nucleotide binding region [chemical binding]; other site 693746005272 ATP-binding site [chemical binding]; other site 693746005273 Mitochondrial degradasome RNA helicase subunit C terminal; Region: SUV3_C; pfam12513 693746005274 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 693746005275 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746005276 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 693746005277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746005278 dimerization interface [polypeptide binding]; other site 693746005279 putative DNA binding site [nucleotide binding]; other site 693746005280 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746005281 putative Zn2+ binding site [ion binding]; other site 693746005282 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 693746005283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746005284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746005285 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693746005286 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746005287 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 693746005288 DNA binding residues [nucleotide binding] 693746005289 dimer interface [polypeptide binding]; other site 693746005290 RDD family; Region: RDD; pfam06271 693746005291 Protein of unknown function (DUF4001); Region: DUF4001; pfam13165 693746005292 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 693746005293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746005294 FeS/SAM binding site; other site 693746005295 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 693746005296 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 693746005297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746005298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746005299 catalytic residue [active] 693746005300 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 693746005301 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746005302 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746005303 Magnesium ion binding site [ion binding]; other site 693746005304 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 693746005305 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746005306 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746005307 non-specific DNA binding site [nucleotide binding]; other site 693746005308 salt bridge; other site 693746005309 sequence-specific DNA binding site [nucleotide binding]; other site 693746005310 peroxiredoxin; Provisional; Region: PRK13189 693746005311 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693746005312 Transposase; Region: HTH_Tnp_1; pfam01527 693746005313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746005314 HTH-like domain; Region: HTH_21; pfam13276 693746005315 Integrase core domain; Region: rve; pfam00665 693746005316 Integrase core domain; Region: rve_3; pfam13683 693746005317 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 693746005318 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 693746005319 DXD motif; other site 693746005320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746005321 HTH-like domain; Region: HTH_21; pfam13276 693746005322 Integrase core domain; Region: rve; pfam00665 693746005323 Integrase core domain; Region: rve_3; pfam13683 693746005324 Transposase; Region: HTH_Tnp_1; pfam01527 693746005325 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 693746005326 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 693746005327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746005328 dimer interface [polypeptide binding]; other site 693746005329 conserved gate region; other site 693746005330 putative PBP binding loops; other site 693746005331 ABC-ATPase subunit interface; other site 693746005332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746005333 dimer interface [polypeptide binding]; other site 693746005334 conserved gate region; other site 693746005335 putative PBP binding loops; other site 693746005336 ABC-ATPase subunit interface; other site 693746005337 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693746005338 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 693746005339 Walker A/P-loop; other site 693746005340 ATP binding site [chemical binding]; other site 693746005341 Q-loop/lid; other site 693746005342 ABC transporter signature motif; other site 693746005343 Walker B; other site 693746005344 D-loop; other site 693746005345 H-loop/switch region; other site 693746005346 TOBE domain; Region: TOBE_2; pfam08402 693746005347 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693746005348 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746005349 RNA binding surface [nucleotide binding]; other site 693746005350 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693746005351 active site 693746005352 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 693746005353 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 693746005354 GTP-binding protein Der; Reviewed; Region: PRK00093 693746005355 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 693746005356 G1 box; other site 693746005357 GTP/Mg2+ binding site [chemical binding]; other site 693746005358 Switch I region; other site 693746005359 G2 box; other site 693746005360 Switch II region; other site 693746005361 G3 box; other site 693746005362 G4 box; other site 693746005363 G5 box; other site 693746005364 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 693746005365 G1 box; other site 693746005366 GTP/Mg2+ binding site [chemical binding]; other site 693746005367 Switch I region; other site 693746005368 G2 box; other site 693746005369 G3 box; other site 693746005370 Switch II region; other site 693746005371 G4 box; other site 693746005372 G5 box; other site 693746005373 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 693746005374 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 693746005375 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 693746005376 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693746005377 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 693746005378 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 693746005379 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 693746005380 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 693746005381 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 693746005382 Hpr binding site; other site 693746005383 active site 693746005384 homohexamer subunit interaction site [polypeptide binding]; other site 693746005385 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 693746005386 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 693746005387 nucleotide binding site [chemical binding]; other site 693746005388 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 693746005389 FAD binding domain; Region: FAD_binding_4; pfam01565 693746005390 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 693746005391 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 693746005392 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693746005393 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 693746005394 phosphate binding site [ion binding]; other site 693746005395 putative substrate binding pocket [chemical binding]; other site 693746005396 dimer interface [polypeptide binding]; other site 693746005397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 693746005398 LAGLIDADG-like domain; Region: LAGLIDADG_3; cl08299 693746005399 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 693746005400 Chloramphenicol acetyltransferase; Region: CAT; cl02008 693746005401 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 693746005402 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 693746005403 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 693746005404 active site 693746005405 PHP Thumb interface [polypeptide binding]; other site 693746005406 metal binding site [ion binding]; metal-binding site 693746005407 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 693746005408 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 693746005409 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 693746005410 generic binding surface II; other site 693746005411 generic binding surface I; other site 693746005412 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 693746005413 proposed active site lysine [active] 693746005414 conserved cys residue [active] 693746005415 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693746005416 homodimer interface [polypeptide binding]; other site 693746005417 substrate-cofactor binding pocket; other site 693746005418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746005419 catalytic residue [active] 693746005420 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 693746005421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746005422 S-adenosylmethionine binding site [chemical binding]; other site 693746005423 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 693746005424 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693746005425 Walker A/P-loop; other site 693746005426 ATP binding site [chemical binding]; other site 693746005427 Q-loop/lid; other site 693746005428 ABC transporter signature motif; other site 693746005429 Walker B; other site 693746005430 D-loop; other site 693746005431 H-loop/switch region; other site 693746005432 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 693746005433 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 693746005434 Walker A/P-loop; other site 693746005435 ATP binding site [chemical binding]; other site 693746005436 Q-loop/lid; other site 693746005437 ABC transporter signature motif; other site 693746005438 Walker B; other site 693746005439 D-loop; other site 693746005440 H-loop/switch region; other site 693746005441 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 693746005442 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 693746005443 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 693746005444 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 693746005445 dimerization interface 3.5A [polypeptide binding]; other site 693746005446 active site 693746005447 Colicin V production protein; Region: Colicin_V; pfam02674 693746005448 Colicin V production protein; Region: Colicin_V; pfam02674 693746005449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005450 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746005451 Walker A motif; other site 693746005452 ATP binding site [chemical binding]; other site 693746005453 Walker B motif; other site 693746005454 arginine finger; other site 693746005455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005456 Walker A motif; other site 693746005457 ATP binding site [chemical binding]; other site 693746005458 Walker B motif; other site 693746005459 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 693746005460 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746005461 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693746005462 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693746005463 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693746005464 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693746005465 hypothetical protein; Provisional; Region: PRK06851 693746005466 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 693746005467 homodimer interaction site [polypeptide binding]; other site 693746005468 cofactor binding site; other site 693746005469 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 693746005470 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 693746005471 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 693746005472 active site 693746005473 dimer interface [polypeptide binding]; other site 693746005474 motif 1; other site 693746005475 motif 2; other site 693746005476 motif 3; other site 693746005477 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 693746005478 anticodon binding site; other site 693746005479 pyruvate carboxylase; Reviewed; Region: PRK12999 693746005480 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693746005481 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693746005482 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693746005483 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 693746005484 active site 693746005485 catalytic residues [active] 693746005486 metal binding site [ion binding]; metal-binding site 693746005487 homodimer binding site [polypeptide binding]; other site 693746005488 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 693746005489 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693746005490 carboxyltransferase (CT) interaction site; other site 693746005491 biotinylation site [posttranslational modification]; other site 693746005492 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 693746005493 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693746005494 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 693746005495 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693746005496 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693746005497 HlyD family secretion protein; Region: HlyD; pfam00529 693746005498 HlyD family secretion protein; Region: HlyD_3; pfam13437 693746005499 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693746005500 HlyD family secretion protein; Region: HlyD_3; pfam13437 693746005501 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746005502 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 693746005503 Walker A/P-loop; other site 693746005504 ATP binding site [chemical binding]; other site 693746005505 Q-loop/lid; other site 693746005506 ABC transporter signature motif; other site 693746005507 Walker B; other site 693746005508 D-loop; other site 693746005509 H-loop/switch region; other site 693746005510 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 693746005511 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 693746005512 FtsX-like permease family; Region: FtsX; pfam02687 693746005513 S-layer homology domain; Region: SLH; pfam00395 693746005514 S-layer homology domain; Region: SLH; pfam00395 693746005515 S-layer homology domain; Region: SLH; pfam00395 693746005516 S-layer homology domain; Region: SLH; pfam00395 693746005517 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 693746005518 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 693746005519 active site 693746005520 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 693746005521 active site 693746005522 metal binding site [ion binding]; metal-binding site 693746005523 dimerization interface [polypeptide binding]; other site 693746005524 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 693746005525 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 693746005526 Domain of unknown function (DUF814); Region: DUF814; pfam05670 693746005527 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 693746005528 Part of AAA domain; Region: AAA_19; pfam13245 693746005529 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693746005530 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693746005531 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693746005532 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 693746005533 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746005534 active site 693746005535 motif I; other site 693746005536 motif II; other site 693746005537 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 693746005538 active site 693746005539 DNA binding site [nucleotide binding] 693746005540 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746005541 EamA-like transporter family; Region: EamA; pfam00892 693746005542 EamA-like transporter family; Region: EamA; pfam00892 693746005543 SdpI/YhfL protein family; Region: SdpI; pfam13630 693746005544 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693746005545 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746005546 DNA-binding site [nucleotide binding]; DNA binding site 693746005547 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 693746005548 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 693746005549 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 693746005550 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 693746005551 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693746005552 tetramer interface [polypeptide binding]; other site 693746005553 TPP-binding site [chemical binding]; other site 693746005554 heterodimer interface [polypeptide binding]; other site 693746005555 phosphorylation loop region [posttranslational modification] 693746005556 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693746005557 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693746005558 alpha subunit interface [polypeptide binding]; other site 693746005559 TPP binding site [chemical binding]; other site 693746005560 heterodimer interface [polypeptide binding]; other site 693746005561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693746005562 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 693746005563 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 693746005564 DctM-like transporters; Region: DctM; pfam06808 693746005565 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746005566 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746005567 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693746005568 tetramer interface [polypeptide binding]; other site 693746005569 TPP-binding site [chemical binding]; other site 693746005570 heterodimer interface [polypeptide binding]; other site 693746005571 phosphorylation loop region [posttranslational modification] 693746005572 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693746005573 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 693746005574 alpha subunit interface [polypeptide binding]; other site 693746005575 TPP binding site [chemical binding]; other site 693746005576 heterodimer interface [polypeptide binding]; other site 693746005577 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693746005578 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 693746005579 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693746005580 E3 interaction surface; other site 693746005581 lipoyl attachment site [posttranslational modification]; other site 693746005582 e3 binding domain; Region: E3_binding; pfam02817 693746005583 e3 binding domain; Region: E3_binding; pfam02817 693746005584 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693746005585 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693746005586 E3 interaction surface; other site 693746005587 lipoyl attachment site [posttranslational modification]; other site 693746005588 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 693746005589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746005590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746005591 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693746005592 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 693746005593 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746005594 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693746005595 RNA binding surface [nucleotide binding]; other site 693746005596 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 693746005597 active site 693746005598 uracil binding [chemical binding]; other site 693746005599 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 693746005600 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 693746005601 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 693746005602 dimerization interface [polypeptide binding]; other site 693746005603 putative protease; Provisional; Region: PRK15452 693746005604 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693746005605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746005606 Sporulation factor SpoIIGA; Region: Peptidase_U4; cl19579 693746005607 sporulation sigma factor SigE; Reviewed; Region: PRK08301 693746005608 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746005609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746005610 DNA binding residues [nucleotide binding] 693746005611 Transglycosylase; Region: Transgly; pfam00912 693746005612 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 693746005613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 693746005614 hypothetical protein; Provisional; Region: PRK04435 693746005615 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 693746005616 DNA-binding interface [nucleotide binding]; DNA binding site 693746005617 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 693746005618 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 693746005619 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 693746005620 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 693746005621 aspartate kinase; Reviewed; Region: PRK06635 693746005622 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 693746005623 putative nucleotide binding site [chemical binding]; other site 693746005624 putative catalytic residues [active] 693746005625 putative Mg ion binding site [ion binding]; other site 693746005626 putative aspartate binding site [chemical binding]; other site 693746005627 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 693746005628 putative allosteric regulatory site; other site 693746005629 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 693746005630 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 693746005631 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 693746005632 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 693746005633 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 693746005634 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 693746005635 ATP cone domain; Region: ATP-cone; pfam03477 693746005636 Class III ribonucleotide reductase; Region: RNR_III; cd01675 693746005637 effector binding site; other site 693746005638 active site 693746005639 Zn binding site [ion binding]; other site 693746005640 glycine loop; other site 693746005641 S-layer homology domain; Region: SLH; pfam00395 693746005642 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 693746005643 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 693746005644 CoA binding domain; Region: CoA_binding; smart00881 693746005645 Cache domain; Region: Cache_1; pfam02743 693746005646 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746005647 dimerization interface [polypeptide binding]; other site 693746005648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746005649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746005650 dimer interface [polypeptide binding]; other site 693746005651 putative CheW interface [polypeptide binding]; other site 693746005652 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 693746005653 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693746005654 trimer interface [polypeptide binding]; other site 693746005655 active site 693746005656 substrate binding site [chemical binding]; other site 693746005657 CoA binding site [chemical binding]; other site 693746005658 CAAX protease self-immunity; Region: Abi; pfam02517 693746005659 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; cl01153 693746005660 CAAX protease self-immunity; Region: Abi; pfam02517 693746005661 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 693746005662 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 693746005663 CotJB protein; Region: CotJB; pfam12652 693746005664 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 693746005665 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 693746005666 active site 693746005667 metal binding site [ion binding]; metal-binding site 693746005668 DNA repair protein RadA; Provisional; Region: PRK11823 693746005669 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 693746005670 Walker A motif/ATP binding site; other site 693746005671 ATP binding site [chemical binding]; other site 693746005672 Walker B motif; other site 693746005673 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693746005674 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693746005675 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746005676 active site 693746005677 DNA binding site [nucleotide binding] 693746005678 Int/Topo IB signature motif; other site 693746005679 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746005680 TspO/MBR family; Region: TspO_MBR; pfam03073 693746005681 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746005682 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746005683 catalytic residues [active] 693746005684 catalytic nucleophile [active] 693746005685 Recombinase; Region: Recombinase; pfam07508 693746005686 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746005687 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 693746005688 dinuclear metal binding motif [ion binding]; other site 693746005689 Transposase domain (DUF772); Region: DUF772; pfam05598 693746005690 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746005691 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746005692 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 693746005693 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 693746005694 nucleotide binding pocket [chemical binding]; other site 693746005695 K-X-D-G motif; other site 693746005696 catalytic site [active] 693746005697 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 693746005698 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 693746005699 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693746005700 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 693746005701 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 693746005702 Dimer interface [polypeptide binding]; other site 693746005703 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 693746005704 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746005705 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 693746005706 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746005707 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746005708 Integrase core domain; Region: rve; pfam00665 693746005709 Integrase core domain; Region: rve_3; cl15866 693746005710 HTH-like domain; Region: HTH_21; pfam13276 693746005711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746005712 Transposase; Region: HTH_Tnp_1; cl17663 693746005713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746005714 Transposase; Region: HTH_Tnp_1; cl17663 693746005715 hypothetical protein; Validated; Region: PRK00110 693746005716 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 693746005717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746005718 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 693746005719 Probable zinc-binding domain; Region: zf-trcl; pfam13451 693746005720 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 693746005721 RNA polymerase factor sigma-70; Validated; Region: PRK08295 693746005722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746005723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 693746005724 DNA binding residues [nucleotide binding] 693746005725 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 693746005726 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 693746005727 active site 693746005728 substrate binding site [chemical binding]; other site 693746005729 metal binding site [ion binding]; metal-binding site 693746005730 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 693746005731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005732 Walker A motif; other site 693746005733 ATP binding site [chemical binding]; other site 693746005734 Walker B motif; other site 693746005735 arginine finger; other site 693746005736 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 693746005737 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 693746005738 RuvA N terminal domain; Region: RuvA_N; pfam01330 693746005739 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693746005740 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 693746005741 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 693746005742 active site 693746005743 putative DNA-binding cleft [nucleotide binding]; other site 693746005744 dimer interface [polypeptide binding]; other site 693746005745 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 693746005746 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746005747 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746005748 DNA binding residues [nucleotide binding] 693746005749 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746005750 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 693746005751 active site 693746005752 DNA binding site [nucleotide binding] 693746005753 Int/Topo IB signature motif; other site 693746005754 Integral membrane protein DUF95; Region: DUF95; cl00572 693746005755 Preprotein translocase subunit; Region: YajC; pfam02699 693746005756 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 693746005757 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 693746005758 TfoX C-terminal domain; Region: TfoX_C; pfam04994 693746005759 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 693746005760 Stage II sporulation protein; Region: SpoIID; pfam08486 693746005761 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 693746005762 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 693746005763 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693746005764 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 693746005765 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693746005766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746005767 ABC transporter; Region: ABC_tran_2; pfam12848 693746005768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746005769 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 693746005770 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 693746005771 active site 693746005772 HIGH motif; other site 693746005773 dimer interface [polypeptide binding]; other site 693746005774 KMSKS motif; other site 693746005775 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746005776 RNA binding surface [nucleotide binding]; other site 693746005777 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 693746005778 Sulfate transporter family; Region: Sulfate_transp; cl19250 693746005779 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 693746005780 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 693746005781 Part of AAA domain; Region: AAA_19; pfam13245 693746005782 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693746005783 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 693746005784 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 693746005785 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 693746005786 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 693746005787 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 693746005788 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 693746005789 active site 693746005790 homodimer interface [polypeptide binding]; other site 693746005791 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 693746005792 Mg++ binding site [ion binding]; other site 693746005793 putative catalytic motif [active] 693746005794 substrate binding site [chemical binding]; other site 693746005795 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 693746005796 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 693746005797 active site 693746005798 HIGH motif; other site 693746005799 dimer interface [polypeptide binding]; other site 693746005800 KMSKS motif; other site 693746005801 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 693746005802 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 693746005803 active site 693746005804 HIGH motif; other site 693746005805 KMSKS motif; other site 693746005806 asparagine synthetase AsnA; Provisional; Region: PRK05425 693746005807 motif 1; other site 693746005808 dimer interface [polypeptide binding]; other site 693746005809 active site 693746005810 motif 2; other site 693746005811 motif 3; other site 693746005812 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 693746005813 oligomer interface [polypeptide binding]; other site 693746005814 putative active site [active] 693746005815 metal binding site [ion binding]; metal-binding site 693746005816 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 693746005817 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 693746005818 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 693746005819 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 693746005820 CoA-binding site [chemical binding]; other site 693746005821 peptide chain release factor 1; Validated; Region: prfA; PRK00591 693746005822 PCRF domain; Region: PCRF; pfam03462 693746005823 RF-1 domain; Region: RF-1; pfam00472 693746005824 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 693746005825 putative active site [active] 693746005826 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693746005827 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746005828 ABC transporter; Region: ABC_tran_2; pfam12848 693746005829 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746005830 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 693746005831 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 693746005832 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746005833 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 693746005834 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 693746005835 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 693746005836 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693746005837 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 693746005838 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 693746005839 V-type ATP synthase subunit B; Provisional; Region: PRK04196 693746005840 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693746005841 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 693746005842 Walker A motif homologous position; other site 693746005843 Walker B motif; other site 693746005844 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693746005845 V-type ATP synthase subunit A; Provisional; Region: PRK04192 693746005846 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693746005847 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 693746005848 Walker A motif/ATP binding site; other site 693746005849 Walker B motif; other site 693746005850 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 693746005851 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 693746005852 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660 693746005853 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 693746005854 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 693746005855 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 693746005856 V-type ATP synthase subunit K; Validated; Region: PRK06558 693746005857 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 693746005858 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 693746005859 V-type ATP synthase subunit I; Validated; Region: PRK05771 693746005860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746005861 putative substrate translocation pore; other site 693746005862 ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926 693746005863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746005864 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 693746005865 Transposase; Region: HTH_Tnp_1; pfam01527 693746005866 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746005867 HTH-like domain; Region: HTH_21; pfam13276 693746005868 Integrase core domain; Region: rve; pfam00665 693746005869 Integrase core domain; Region: rve_3; pfam13683 693746005870 TIGR02594 family protein; Region: TIGR02594 693746005871 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746005872 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 693746005873 Baseplate J-like protein; Region: Baseplate_J; cl01294 693746005874 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 693746005875 Phage P2 GpU; Region: Phage_P2_GpU; cl01391 693746005876 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 693746005877 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 693746005878 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746005879 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 693746005880 Phage tail tube protein FII; Region: Phage_tube; cl01390 693746005881 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 693746005882 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746005883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746005884 Integrase core domain; Region: rve; pfam00665 693746005885 transposase/IS protein; Provisional; Region: PRK09183 693746005886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746005887 Walker A motif; other site 693746005888 ATP binding site [chemical binding]; other site 693746005889 Walker B motif; other site 693746005890 Transposase domain (DUF772); Region: DUF772; pfam05598 693746005891 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746005892 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746005893 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693746005894 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 693746005895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746005896 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746005897 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 693746005898 iron binding site [ion binding]; other site 693746005899 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746005900 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 693746005901 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746005902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746005903 non-specific DNA binding site [nucleotide binding]; other site 693746005904 salt bridge; other site 693746005905 sequence-specific DNA binding site [nucleotide binding]; other site 693746005906 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 693746005907 dimer interface [polypeptide binding]; other site 693746005908 catalytic triad [active] 693746005909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746005910 Zn2+ binding site [ion binding]; other site 693746005911 Mg2+ binding site [ion binding]; other site 693746005912 S-layer homology domain; Region: SLH; pfam00395 693746005913 S-layer homology domain; Region: SLH; pfam00395 693746005914 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693746005915 active site 693746005916 Putative amidase domain; Region: Amidase_6; pfam12671 693746005917 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 693746005918 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 693746005919 intersubunit interface [polypeptide binding]; other site 693746005920 active site 693746005921 zinc binding site [ion binding]; other site 693746005922 Na+ binding site [ion binding]; other site 693746005923 6-phosphofructokinase; Provisional; Region: PRK14072 693746005924 active site 693746005925 ADP/pyrophosphate binding site [chemical binding]; other site 693746005926 dimerization interface [polypeptide binding]; other site 693746005927 allosteric effector site; other site 693746005928 fructose-1,6-bisphosphate binding site; other site 693746005929 Type III pantothenate kinase; Region: Pan_kinase; cl17198 693746005930 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 693746005931 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 693746005932 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 693746005933 DNA binding site [nucleotide binding] 693746005934 active site 693746005935 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 693746005936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 693746005937 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 693746005938 substrate binding pocket [chemical binding]; other site 693746005939 membrane-bound complex binding site; other site 693746005940 hinge residues; other site 693746005941 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693746005942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746005943 dimer interface [polypeptide binding]; other site 693746005944 conserved gate region; other site 693746005945 putative PBP binding loops; other site 693746005946 ABC-ATPase subunit interface; other site 693746005947 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 693746005948 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 693746005949 Walker A/P-loop; other site 693746005950 ATP binding site [chemical binding]; other site 693746005951 Q-loop/lid; other site 693746005952 ABC transporter signature motif; other site 693746005953 Walker B; other site 693746005954 D-loop; other site 693746005955 H-loop/switch region; other site 693746005956 Flavoprotein; Region: Flavoprotein; cl19190 693746005957 potential frameshift: common BLAST hit: gi|328954731|ref|YP_004372064.1| Carboxylyase-related protein 693746005958 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 693746005959 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 693746005960 potential frameshift: common BLAST hit: gi|158319222|ref|YP_001511729.1| coenzyme A transferase 693746005961 Coenzyme A transferase; Region: CoA_trans; cl17247 693746005962 Coenzyme A transferase; Region: CoA_trans; cl17247 693746005963 Integrase core domain; Region: rve; pfam00665 693746005964 Coenzyme A transferase; Region: CoA_trans; cl17247 693746005965 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 693746005966 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 693746005967 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746005968 GTPase RsgA; Reviewed; Region: PRK00098 693746005969 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 693746005970 RNA binding site [nucleotide binding]; other site 693746005971 homodimer interface [polypeptide binding]; other site 693746005972 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693746005973 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693746005974 GTP/Mg2+ binding site [chemical binding]; other site 693746005975 G4 box; other site 693746005976 G5 box; other site 693746005977 G1 box; other site 693746005978 Switch I region; other site 693746005979 G2 box; other site 693746005980 G3 box; other site 693746005981 Switch II region; other site 693746005982 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693746005983 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693746005984 active site 693746005985 ATP binding site [chemical binding]; other site 693746005986 substrate binding site [chemical binding]; other site 693746005987 activation loop (A-loop); other site 693746005988 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693746005989 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693746005990 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 693746005991 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 693746005992 active site 693746005993 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 693746005994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746005995 FeS/SAM binding site; other site 693746005996 16S rRNA methyltransferase B; Provisional; Region: PRK14902 693746005997 NusB family; Region: NusB; pfam01029 693746005998 putative RNA binding site [nucleotide binding]; other site 693746005999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746006000 S-adenosylmethionine binding site [chemical binding]; other site 693746006001 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 693746006002 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 693746006003 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 693746006004 putative active site [active] 693746006005 substrate binding site [chemical binding]; other site 693746006006 putative cosubstrate binding site; other site 693746006007 catalytic site [active] 693746006008 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 693746006009 substrate binding site [chemical binding]; other site 693746006010 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693746006011 active site 693746006012 catalytic residues [active] 693746006013 metal binding site [ion binding]; metal-binding site 693746006014 primosome assembly protein PriA; Validated; Region: PRK05580 693746006015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746006016 ATP binding site [chemical binding]; other site 693746006017 putative Mg++ binding site [ion binding]; other site 693746006018 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cl19048 693746006019 Zn binding sites [ion binding]; other site 693746006020 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693746006021 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 693746006022 Guanylate kinase; Region: Guanylate_kin; pfam00625 693746006023 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 693746006024 catalytic site [active] 693746006025 G-X2-G-X-G-K; other site 693746006026 hypothetical protein; Provisional; Region: PRK04323 693746006027 hypothetical protein; Provisional; Region: PRK11820 693746006028 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 693746006029 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 693746006030 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 693746006031 HSP70 interaction site [polypeptide binding]; other site 693746006032 Tetratricopeptide repeat; Region: TPR_16; pfam13432 693746006033 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 693746006034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 693746006035 YbbR-like protein; Region: YbbR; pfam07949 693746006036 Uncharacterized conserved protein [Function unknown]; Region: COG1624 693746006037 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 693746006038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746006039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746006040 catalytic residue [active] 693746006041 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 693746006042 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 693746006043 homotrimer interaction site [polypeptide binding]; other site 693746006044 zinc binding site [ion binding]; other site 693746006045 CDP-binding sites; other site 693746006046 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 693746006047 substrate binding site; other site 693746006048 dimer interface; other site 693746006049 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 693746006050 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 693746006051 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 693746006052 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693746006053 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 693746006054 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 693746006055 Fe-S cluster binding site [ion binding]; other site 693746006056 substrate binding site [chemical binding]; other site 693746006057 catalytic site [active] 693746006058 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 693746006059 RNA binding site [nucleotide binding]; other site 693746006060 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 693746006061 RNA binding site [nucleotide binding]; other site 693746006062 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 693746006063 RNA binding site [nucleotide binding]; other site 693746006064 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693746006065 RNA binding site [nucleotide binding]; other site 693746006066 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 693746006067 putative acyl-acceptor binding pocket; other site 693746006068 cytidylate kinase; Provisional; Region: cmk; PRK00023 693746006069 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 693746006070 CMP-binding site; other site 693746006071 The sites determining sugar specificity; other site 693746006072 flavoprotein, HI0933 family; Region: TIGR00275 693746006073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746006074 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693746006075 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693746006076 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693746006077 putative active site [active] 693746006078 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 693746006079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746006080 RNA binding surface [nucleotide binding]; other site 693746006081 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 693746006082 active site 693746006083 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 693746006084 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 693746006085 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 693746006086 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 693746006087 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 693746006088 ScpA/B protein; Region: ScpA_ScpB; cl00598 693746006089 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 693746006090 Peptidase family M50; Region: Peptidase_M50; pfam02163 693746006091 active site 693746006092 putative substrate binding region [chemical binding]; other site 693746006093 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 693746006094 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 693746006095 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693746006096 Walker A/P-loop; other site 693746006097 ATP binding site [chemical binding]; other site 693746006098 Q-loop/lid; other site 693746006099 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 693746006100 ABC transporter signature motif; other site 693746006101 Walker B; other site 693746006102 D-loop; other site 693746006103 H-loop/switch region; other site 693746006104 Arginine repressor [Transcription]; Region: ArgR; COG1438 693746006105 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 693746006106 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 693746006107 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 693746006108 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 693746006109 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746006110 RNA binding surface [nucleotide binding]; other site 693746006111 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 693746006112 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 693746006113 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 693746006114 TPP-binding site; other site 693746006115 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693746006116 PYR/PP interface [polypeptide binding]; other site 693746006117 dimer interface [polypeptide binding]; other site 693746006118 TPP binding site [chemical binding]; other site 693746006119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693746006120 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 693746006121 substrate binding pocket [chemical binding]; other site 693746006122 chain length determination region; other site 693746006123 active site lid residues [active] 693746006124 substrate-Mg2+ binding site; other site 693746006125 catalytic residues [active] 693746006126 aspartate-rich region 1; other site 693746006127 aspartate-rich region 2; other site 693746006128 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 693746006129 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 693746006130 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 693746006131 generic binding surface II; other site 693746006132 generic binding surface I; other site 693746006133 transcription antitermination factor NusB; Region: nusB; TIGR01951 693746006134 putative RNA binding site [nucleotide binding]; other site 693746006135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 693746006136 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 693746006137 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 693746006138 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl17562 693746006139 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 693746006140 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 693746006141 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 693746006142 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 693746006143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693746006144 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 693746006145 SIR2-like domain; Region: SIR2_2; pfam13289 693746006146 RIM-binding protein of the cytomatrix active zone; Region: Cast; pfam10174 693746006147 NlpC/P60 family; Region: NLPC_P60; cl17555 693746006148 Holin family; Region: Phage_holin_4; cl01989 693746006149 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746006150 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 693746006151 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 693746006152 Terminase small subunit; Region: Terminase_2; cl01513 693746006153 large terminase protein; Provisional; Region: 17; PHA02533 693746006154 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 693746006155 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746006156 PcfJ-like protein; Region: PcfJ; pfam14284 693746006157 PcfK-like protein; Region: PcfK; pfam14058 693746006158 3D domain; Region: 3D; cl01439 693746006159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006160 non-specific DNA binding site [nucleotide binding]; other site 693746006161 salt bridge; other site 693746006162 sequence-specific DNA binding site [nucleotide binding]; other site 693746006163 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746006164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006165 non-specific DNA binding site [nucleotide binding]; other site 693746006166 salt bridge; other site 693746006167 sequence-specific DNA binding site [nucleotide binding]; other site 693746006168 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693746006169 AAA domain; Region: AAA_11; pfam13086 693746006170 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746006171 ATP binding site [chemical binding]; other site 693746006172 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 693746006173 AAA domain; Region: AAA_12; pfam13087 693746006174 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746006175 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746006176 catalytic residues [active] 693746006177 catalytic nucleophile [active] 693746006178 Recombinase; Region: Recombinase; pfam07508 693746006179 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746006180 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 693746006181 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 693746006182 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 693746006183 putative acyltransferase; Provisional; Region: PRK05790 693746006184 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693746006185 dimer interface [polypeptide binding]; other site 693746006186 active site 693746006187 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 693746006188 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693746006189 substrate binding site [chemical binding]; other site 693746006190 oxyanion hole (OAH) forming residues; other site 693746006191 trimer interface [polypeptide binding]; other site 693746006192 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 693746006193 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 693746006194 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 693746006195 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 693746006196 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 693746006197 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 693746006198 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746006199 PAS domain; Region: PAS_9; pfam13426 693746006200 putative active site [active] 693746006201 heme pocket [chemical binding]; other site 693746006202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746006203 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693746006204 Walker A motif; other site 693746006205 ATP binding site [chemical binding]; other site 693746006206 Walker B motif; other site 693746006207 arginine finger; other site 693746006208 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693746006209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746006210 Glucose inhibited division protein A; Region: GIDA; pfam01134 693746006211 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 693746006212 aspartate aminotransferase; Provisional; Region: PRK05764 693746006213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746006214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746006215 homodimer interface [polypeptide binding]; other site 693746006216 catalytic residue [active] 693746006217 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693746006218 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 693746006219 NAD binding site [chemical binding]; other site 693746006220 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746006221 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 693746006222 ligand binding site [chemical binding]; other site 693746006223 NAD binding site [chemical binding]; other site 693746006224 dimerization interface [polypeptide binding]; other site 693746006225 catalytic site [active] 693746006226 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 693746006227 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 693746006228 hypothetical protein; Provisional; Region: PRK07475 693746006229 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 693746006230 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746006231 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746006232 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746006233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746006234 elongation factor Ts; Provisional; Region: tsf; PRK09377 693746006235 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cd00194 693746006236 putative protein-protein interaction site; other site 693746006237 GFP-loop; other site 693746006238 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 693746006239 rRNA interaction site [nucleotide binding]; other site 693746006240 S8 interaction site; other site 693746006241 putative laminin-1 binding site; other site 693746006242 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 693746006243 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 693746006244 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693746006245 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746006246 Walker A/P-loop; other site 693746006247 ATP binding site [chemical binding]; other site 693746006248 Q-loop/lid; other site 693746006249 ABC transporter signature motif; other site 693746006250 Walker B; other site 693746006251 D-loop; other site 693746006252 H-loop/switch region; other site 693746006253 sporulation sigma factor SigG; Reviewed; Region: PRK08215 693746006254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746006255 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693746006256 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746006257 DNA binding residues [nucleotide binding] 693746006258 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 693746006259 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693746006260 active site 693746006261 nucleotide binding site [chemical binding]; other site 693746006262 HIGH motif; other site 693746006263 KMSKS motif; other site 693746006264 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 693746006265 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 693746006266 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 693746006267 active site 693746006268 metal binding site [ion binding]; metal-binding site 693746006269 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 693746006270 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 693746006271 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 693746006272 Competence protein; Region: Competence; pfam03772 693746006273 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746006274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746006275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006276 non-specific DNA binding site [nucleotide binding]; other site 693746006277 salt bridge; other site 693746006278 sequence-specific DNA binding site [nucleotide binding]; other site 693746006279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746006280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006281 non-specific DNA binding site [nucleotide binding]; other site 693746006282 salt bridge; other site 693746006283 sequence-specific DNA binding site [nucleotide binding]; other site 693746006284 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 693746006285 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 693746006286 Inclusion body protein; Region: PixA; pfam12306 693746006287 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746006288 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 693746006289 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746006290 catalytic residue [active] 693746006291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746006292 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 693746006293 transposase/IS protein; Provisional; Region: PRK09183 693746006294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746006295 Walker A motif; other site 693746006296 ATP binding site [chemical binding]; other site 693746006297 Walker B motif; other site 693746006298 arginine finger; other site 693746006299 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746006300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746006301 Integrase core domain; Region: rve; pfam00665 693746006302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746006303 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 693746006304 active site 693746006305 dimer interface [polypeptide binding]; other site 693746006306 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746006307 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746006308 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746006309 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693746006310 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693746006311 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693746006312 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693746006313 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746006314 Transposase; Region: HTH_Tnp_1; cl17663 693746006315 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746006316 HTH-like domain; Region: HTH_21; pfam13276 693746006317 Integrase core domain; Region: rve; pfam00665 693746006318 Integrase core domain; Region: rve_3; cl15866 693746006319 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 693746006320 Maff2 family; Region: Maff2; pfam12750 693746006321 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746006322 Predicted membrane protein [Function unknown]; Region: COG4709 693746006323 Transposase; Region: HTH_Tnp_1; pfam01527 693746006324 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746006325 HTH-like domain; Region: HTH_21; pfam13276 693746006326 Integrase core domain; Region: rve; pfam00665 693746006327 Integrase core domain; Region: rve_3; pfam13683 693746006328 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746006329 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746006330 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746006331 DNA binding residues [nucleotide binding] 693746006332 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 693746006333 NlpC/P60 family; Region: NLPC_P60; cl17555 693746006334 Holin family; Region: Phage_holin_4; cl01989 693746006335 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 693746006336 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 693746006337 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 693746006338 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 693746006339 Baseplate J-like protein; Region: Baseplate_J; pfam04865 693746006340 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 693746006341 Phage Tail Protein X; Region: Phage_tail_X; cl02088 693746006342 Phage-related minor tail protein [Function unknown]; Region: COG5280 693746006343 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 693746006344 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 693746006345 Phage tail tube protein FII; Region: Phage_tube; cl01390 693746006346 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 693746006347 transcription termination factor Rho; Provisional; Region: PRK12678 693746006348 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 693746006349 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 693746006350 oligomer interface [polypeptide binding]; other site 693746006351 active site residues [active] 693746006352 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 693746006353 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 693746006354 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 693746006355 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 693746006356 Homeodomain-like domain; Region: HTH_23; cl17451 693746006357 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746006358 Coenzyme A binding pocket [chemical binding]; other site 693746006359 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693746006360 active site 693746006361 DNA polymerase III subunit beta; Validated; Region: PRK05643 693746006362 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 693746006363 putative DNA binding surface [nucleotide binding]; other site 693746006364 dimer interface [polypeptide binding]; other site 693746006365 beta-clamp/clamp loader binding surface; other site 693746006366 beta-clamp/translesion DNA polymerase binding surface; other site 693746006367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746006368 FeS/SAM binding site; other site 693746006369 Uncharacterized conserved protein [Function unknown]; Region: COG4933 693746006370 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 693746006371 PcfJ-like protein; Region: PcfJ; pfam14284 693746006372 PcfK-like protein; Region: PcfK; pfam14058 693746006373 3D domain; Region: 3D; cl01439 693746006374 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 693746006375 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746006376 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006377 salt bridge; other site 693746006378 non-specific DNA binding site [nucleotide binding]; other site 693746006379 sequence-specific DNA binding site [nucleotide binding]; other site 693746006380 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 693746006381 Reversibly glycosylated polypeptide; Region: RGP; cl07847 693746006382 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746006383 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693746006384 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746006385 active site 693746006386 DNA binding site [nucleotide binding] 693746006387 Int/Topo IB signature motif; other site 693746006388 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693746006389 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746006390 Peptidase family M50; Region: Peptidase_M50; pfam02163 693746006391 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 693746006392 active site 693746006393 putative substrate binding region [chemical binding]; other site 693746006394 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 693746006395 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 693746006396 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 693746006397 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 693746006398 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 693746006399 dimer interface [polypeptide binding]; other site 693746006400 putative anticodon binding site; other site 693746006401 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 693746006402 motif 1; other site 693746006403 active site 693746006404 motif 2; other site 693746006405 motif 3; other site 693746006406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746006407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 693746006408 homodimer interface [polypeptide binding]; other site 693746006409 chemical substrate binding site [chemical binding]; other site 693746006410 oligomer interface [polypeptide binding]; other site 693746006411 metal binding site [ion binding]; metal-binding site 693746006412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693746006413 ATP binding site [chemical binding]; other site 693746006414 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 693746006415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 693746006416 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746006417 nucleotide binding region [chemical binding]; other site 693746006418 RQC domain; Region: RQC; pfam09382 693746006419 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 693746006420 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 693746006421 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 693746006422 metal binding site [ion binding]; metal-binding site 693746006423 dimer interface [polypeptide binding]; other site 693746006424 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402 693746006425 OPT oligopeptide transporter protein; Region: OPT; cl14607 693746006426 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 693746006427 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693746006428 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693746006429 putative NAD(P) binding site [chemical binding]; other site 693746006430 aspartate aminotransferase; Provisional; Region: PRK07568 693746006431 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746006432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746006433 homodimer interface [polypeptide binding]; other site 693746006434 catalytic residue [active] 693746006435 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 693746006436 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 693746006437 HerA helicase [Replication, recombination, and repair]; Region: COG0433 693746006438 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693746006439 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746006440 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 693746006441 Bacitracin resistance protein BacA; Region: BacA; pfam02673 693746006442 ribonuclease III; Reviewed; Region: rnc; PRK00102 693746006443 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 693746006444 dimerization interface [polypeptide binding]; other site 693746006445 active site 693746006446 metal binding site [ion binding]; metal-binding site 693746006447 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 693746006448 dsRNA binding site [nucleotide binding]; other site 693746006449 acyl carrier protein; Provisional; Region: acpP; PRK00982 693746006450 putative phosphate acyltransferase; Provisional; Region: PRK05331 693746006451 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 693746006452 Glucose inhibited division protein A; Region: GIDA; pfam01134 693746006453 DNA topoisomerase I; Validated; Region: PRK05582 693746006454 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 693746006455 active site 693746006456 interdomain interaction site; other site 693746006457 putative metal-binding site [ion binding]; other site 693746006458 nucleotide binding site [chemical binding]; other site 693746006459 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693746006460 domain I; other site 693746006461 DNA binding groove [nucleotide binding] 693746006462 phosphate binding site [ion binding]; other site 693746006463 domain II; other site 693746006464 domain III; other site 693746006465 nucleotide binding site [chemical binding]; other site 693746006466 catalytic site [active] 693746006467 domain IV; other site 693746006468 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 693746006469 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 693746006470 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693746006471 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 693746006472 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693746006473 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 693746006474 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693746006475 Mechanosensitive ion channel porin domain; Region: MscS_porin; pfam12795 693746006476 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 693746006477 linker region; other site 693746006478 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693746006479 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746006480 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 693746006481 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 693746006482 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 693746006483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746006484 Walker A/P-loop; other site 693746006485 ATP binding site [chemical binding]; other site 693746006486 Q-loop/lid; other site 693746006487 ABC transporter signature motif; other site 693746006488 Walker B; other site 693746006489 D-loop; other site 693746006490 H-loop/switch region; other site 693746006491 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 693746006492 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 693746006493 selenophosphate synthetase; Provisional; Region: PRK00943 693746006494 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 693746006495 dimerization interface [polypeptide binding]; other site 693746006496 putative ATP binding site [chemical binding]; other site 693746006497 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 693746006498 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 693746006499 G1 box; other site 693746006500 putative GEF interaction site [polypeptide binding]; other site 693746006501 GTP/Mg2+ binding site [chemical binding]; other site 693746006502 Switch I region; other site 693746006503 G2 box; other site 693746006504 G3 box; other site 693746006505 Switch II region; other site 693746006506 G4 box; other site 693746006507 G5 box; other site 693746006508 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 693746006509 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 693746006510 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 693746006511 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 693746006512 Walker A motif; other site 693746006513 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 693746006514 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 693746006515 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 693746006516 P loop nucleotide binding; other site 693746006517 switch II; other site 693746006518 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 693746006519 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 693746006520 P loop nucleotide binding; other site 693746006521 switch II; other site 693746006522 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 693746006523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746006524 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746006525 DNA binding residues [nucleotide binding] 693746006526 S-layer homology domain; Region: SLH; pfam00395 693746006527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746006528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746006529 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 693746006530 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 693746006531 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 693746006532 HAMP domain; Region: HAMP; pfam00672 693746006533 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 693746006534 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 693746006535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746006536 dimerization interface [polypeptide binding]; other site 693746006537 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 693746006538 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746006539 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746006540 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693746006541 anti sigma factor interaction site; other site 693746006542 regulatory phosphorylation site [posttranslational modification]; other site 693746006543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746006544 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746006545 Walker A motif; other site 693746006546 ATP binding site [chemical binding]; other site 693746006547 Walker B motif; other site 693746006548 arginine finger; other site 693746006549 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 693746006550 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 693746006551 MORN repeat; Region: MORN; cl14787 693746006552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 693746006553 MORN repeat; Region: MORN; cl14787 693746006554 MORN repeat; Region: MORN; cl14787 693746006555 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 693746006556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746006557 dimerization interface [polypeptide binding]; other site 693746006558 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693746006559 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 693746006560 metal binding site [ion binding]; metal-binding site 693746006561 phage tail protein domain; Region: tail_TIGR02242 693746006562 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 693746006563 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 693746006564 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 693746006565 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 693746006566 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 693746006567 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746006568 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 693746006569 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 693746006570 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 693746006571 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 693746006572 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 693746006573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 693746006574 intermolecular recognition site; other site 693746006575 active site 693746006576 dimerization interface [polypeptide binding]; other site 693746006577 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746006578 LytTr DNA-binding domain; Region: LytTR; smart00850 693746006579 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746006580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746006581 active site 693746006582 phosphorylation site [posttranslational modification] 693746006583 intermolecular recognition site; other site 693746006584 dimerization interface [polypeptide binding]; other site 693746006585 LytTr DNA-binding domain; Region: LytTR; pfam04397 693746006586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746006587 ATP binding site [chemical binding]; other site 693746006588 Mg2+ binding site [ion binding]; other site 693746006589 G-X-G motif; other site 693746006590 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693746006591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746006592 DNA-binding site [nucleotide binding]; DNA binding site 693746006593 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746006594 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746006595 homodimer interface [polypeptide binding]; other site 693746006596 catalytic residue [active] 693746006597 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 693746006598 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 693746006599 active site 693746006600 substrate binding site [chemical binding]; other site 693746006601 trimer interface [polypeptide binding]; other site 693746006602 CoA binding site [chemical binding]; other site 693746006603 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 693746006604 active site 1 [active] 693746006605 active site 2 [active] 693746006606 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 693746006607 nucleotide binding site/active site [active] 693746006608 HIT family signature motif; other site 693746006609 catalytic residue [active] 693746006610 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 693746006611 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 693746006612 motif 1; other site 693746006613 active site 693746006614 motif 2; other site 693746006615 motif 3; other site 693746006616 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 693746006617 DHHA1 domain; Region: DHHA1; pfam02272 693746006618 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746006619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006620 non-specific DNA binding site [nucleotide binding]; other site 693746006621 salt bridge; other site 693746006622 sequence-specific DNA binding site [nucleotide binding]; other site 693746006623 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 693746006624 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 693746006625 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 693746006626 RNA binding site [nucleotide binding]; other site 693746006627 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 693746006628 RNA binding site [nucleotide binding]; other site 693746006629 recombination factor protein RarA; Reviewed; Region: PRK13342 693746006630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746006631 Walker A motif; other site 693746006632 ATP binding site [chemical binding]; other site 693746006633 Walker B motif; other site 693746006634 arginine finger; other site 693746006635 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 693746006636 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 693746006637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746006638 putative DNA binding site [nucleotide binding]; other site 693746006639 putative Zn2+ binding site [ion binding]; other site 693746006640 AsnC family; Region: AsnC_trans_reg; pfam01037 693746006641 oxaloacetate decarboxylase; Provisional; Region: PRK12331 693746006642 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 693746006643 active site 693746006644 catalytic residues [active] 693746006645 metal binding site [ion binding]; metal-binding site 693746006646 homodimer binding site [polypeptide binding]; other site 693746006647 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 693746006648 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 693746006649 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693746006650 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693746006651 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 693746006652 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 693746006653 active sites [active] 693746006654 tetramer interface [polypeptide binding]; other site 693746006655 Trp repressor protein; Region: Trp_repressor; cl17266 693746006656 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746006657 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693746006658 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746006659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746006660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746006661 Walker A/P-loop; other site 693746006662 ATP binding site [chemical binding]; other site 693746006663 Q-loop/lid; other site 693746006664 ABC transporter signature motif; other site 693746006665 Walker B; other site 693746006666 D-loop; other site 693746006667 H-loop/switch region; other site 693746006668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746006669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746006670 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 693746006671 Walker A/P-loop; other site 693746006672 ATP binding site [chemical binding]; other site 693746006673 Q-loop/lid; other site 693746006674 ABC transporter signature motif; other site 693746006675 Walker B; other site 693746006676 D-loop; other site 693746006677 H-loop/switch region; other site 693746006678 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 693746006679 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 693746006680 putative NADH binding site [chemical binding]; other site 693746006681 putative active site [active] 693746006682 nudix motif; other site 693746006683 putative metal binding site [ion binding]; other site 693746006684 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 693746006685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746006686 dimer interface [polypeptide binding]; other site 693746006687 conserved gate region; other site 693746006688 putative PBP binding loops; other site 693746006689 ABC-ATPase subunit interface; other site 693746006690 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746006691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746006692 dimer interface [polypeptide binding]; other site 693746006693 conserved gate region; other site 693746006694 putative PBP binding loops; other site 693746006695 ABC-ATPase subunit interface; other site 693746006696 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 693746006697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746006698 Walker A/P-loop; other site 693746006699 ATP binding site [chemical binding]; other site 693746006700 Q-loop/lid; other site 693746006701 ABC transporter signature motif; other site 693746006702 Walker B; other site 693746006703 D-loop; other site 693746006704 H-loop/switch region; other site 693746006705 FOG: CBS domain [General function prediction only]; Region: COG0517 693746006706 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 693746006707 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 693746006708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746006709 DNA-binding site [nucleotide binding]; DNA binding site 693746006710 TrkA-C domain; Region: TrkA_C; pfam02080 693746006711 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746006712 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 693746006713 putative acetyltransferase; Provisional; Region: PRK03624 693746006714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746006715 Coenzyme A binding pocket [chemical binding]; other site 693746006716 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746006717 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 693746006718 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 693746006719 Predicted membrane protein [Function unknown]; Region: COG2323 693746006720 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 693746006721 Cl- selectivity filter; other site 693746006722 Cl- binding residues [ion binding]; other site 693746006723 pore gating glutamate residue; other site 693746006724 dimer interface [polypeptide binding]; other site 693746006725 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 693746006726 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746006727 catalytic residue [active] 693746006728 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 693746006729 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746006730 NAD binding site [chemical binding]; other site 693746006731 phenylhydantoinase; Validated; Region: PRK08323 693746006732 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 693746006733 tetramer interface [polypeptide binding]; other site 693746006734 active site 693746006735 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 693746006736 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693746006737 active site 693746006738 metal binding site [ion binding]; metal-binding site 693746006739 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693746006740 S-layer homology domain; Region: SLH; pfam00395 693746006741 S-layer homology domain; Region: SLH; pfam00395 693746006742 S-layer homology domain; Region: SLH; pfam00395 693746006743 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 693746006744 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 693746006745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746006746 active site 693746006747 phosphorylation site [posttranslational modification] 693746006748 intermolecular recognition site; other site 693746006749 dimerization interface [polypeptide binding]; other site 693746006750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746006751 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746006752 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 693746006753 Histidine kinase; Region: His_kinase; pfam06580 693746006754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746006755 ATP binding site [chemical binding]; other site 693746006756 Mg2+ binding site [ion binding]; other site 693746006757 G-X-G motif; other site 693746006758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746006759 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693746006760 Walker A/P-loop; other site 693746006761 ATP binding site [chemical binding]; other site 693746006762 Q-loop/lid; other site 693746006763 ABC transporter signature motif; other site 693746006764 Walker B; other site 693746006765 D-loop; other site 693746006766 H-loop/switch region; other site 693746006767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746006768 Walker A/P-loop; other site 693746006769 ATP binding site [chemical binding]; other site 693746006770 ABC transporter signature motif; other site 693746006771 Walker B; other site 693746006772 D-loop; other site 693746006773 H-loop/switch region; other site 693746006774 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 693746006775 N- and C-terminal domain interface [polypeptide binding]; other site 693746006776 D-xylulose kinase; Region: XylB; TIGR01312 693746006777 active site 693746006778 MgATP binding site [chemical binding]; other site 693746006779 catalytic site [active] 693746006780 metal binding site [ion binding]; metal-binding site 693746006781 xylulose binding site [chemical binding]; other site 693746006782 homodimer interface [polypeptide binding]; other site 693746006783 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 693746006784 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 693746006785 active site 693746006786 catalytic residues [active] 693746006787 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 693746006788 substrate binding site [chemical binding]; other site 693746006789 ATP binding site [chemical binding]; other site 693746006790 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 693746006791 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 693746006792 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 693746006793 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693746006794 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693746006795 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 693746006796 TM-ABC transporter signature motif; other site 693746006797 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 693746006798 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746006799 Walker A/P-loop; other site 693746006800 ATP binding site [chemical binding]; other site 693746006801 Q-loop/lid; other site 693746006802 ABC transporter signature motif; other site 693746006803 Walker B; other site 693746006804 D-loop; other site 693746006805 H-loop/switch region; other site 693746006806 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693746006807 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 693746006808 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 693746006809 E3 interaction surface; other site 693746006810 lipoyl attachment site [posttranslational modification]; other site 693746006811 e3 binding domain; Region: E3_binding; pfam02817 693746006812 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 693746006813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746006814 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746006815 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 693746006816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746006817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746006818 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693746006819 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 693746006820 tetramer interface [polypeptide binding]; other site 693746006821 TPP-binding site [chemical binding]; other site 693746006822 heterodimer interface [polypeptide binding]; other site 693746006823 phosphorylation loop region [posttranslational modification] 693746006824 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 693746006825 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 693746006826 PYR/PP interface [polypeptide binding]; other site 693746006827 dimer interface [polypeptide binding]; other site 693746006828 TPP binding site [chemical binding]; other site 693746006829 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693746006830 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 693746006831 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 693746006832 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 693746006833 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 693746006834 Flavin Reductases; Region: FlaRed; cl00801 693746006835 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 693746006836 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 693746006837 HflX GTPase family; Region: HflX; cd01878 693746006838 G1 box; other site 693746006839 GTP/Mg2+ binding site [chemical binding]; other site 693746006840 Switch I region; other site 693746006841 G2 box; other site 693746006842 G3 box; other site 693746006843 Switch II region; other site 693746006844 G4 box; other site 693746006845 G5 box; other site 693746006846 Uncharacterized conserved protein [Function unknown]; Region: COG1739 693746006847 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 693746006848 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 693746006849 Transposase domain (DUF772); Region: DUF772; pfam05598 693746006850 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746006851 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746006852 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746006853 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746006854 Homeodomain-like domain; Region: HTH_32; pfam13565 693746006855 Integrase core domain; Region: rve; pfam00665 693746006856 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746006857 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746006858 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746006859 CAAX protease self-immunity; Region: Abi; pfam02517 693746006860 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 693746006861 glycosyltransferase, MGT family; Region: MGT; TIGR01426 693746006862 active site 693746006863 TDP-binding site; other site 693746006864 acceptor substrate-binding pocket; other site 693746006865 homodimer interface [polypeptide binding]; other site 693746006866 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746006867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746006868 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746006869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746006870 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 693746006871 heterodimer interface [polypeptide binding]; other site 693746006872 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 693746006873 tape measure domain; Region: tape_meas_nterm; TIGR02675 693746006874 Phage XkdN-like protein; Region: XkdN; pfam08890 693746006875 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 693746006876 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 693746006877 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 693746006878 oligomerization interface [polypeptide binding]; other site 693746006879 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 693746006880 Phage capsid family; Region: Phage_capsid; pfam05065 693746006881 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 693746006882 oligomer interface [polypeptide binding]; other site 693746006883 active site residues [active] 693746006884 Phage portal protein; Region: Phage_portal; pfam04860 693746006885 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746006886 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746006887 P-loop; other site 693746006888 Magnesium ion binding site [ion binding]; other site 693746006889 replicative DNA helicase; Region: DnaB; TIGR00665 693746006890 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693746006891 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746006892 Walker A motif; other site 693746006893 ATP binding site [chemical binding]; other site 693746006894 Walker B motif; other site 693746006895 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746006896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006897 salt bridge; other site 693746006898 non-specific DNA binding site [nucleotide binding]; other site 693746006899 sequence-specific DNA binding site [nucleotide binding]; other site 693746006900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006901 non-specific DNA binding site [nucleotide binding]; other site 693746006902 salt bridge; other site 693746006903 sequence-specific DNA binding site [nucleotide binding]; other site 693746006904 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 693746006905 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693746006906 active site 693746006907 catalytic residues [active] 693746006908 DNA binding site [nucleotide binding] 693746006909 Int/Topo IB signature motif; other site 693746006910 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 693746006911 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 693746006912 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 693746006913 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693746006914 Cache domain; Region: Cache_1; pfam02743 693746006915 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746006916 dimerization interface [polypeptide binding]; other site 693746006917 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746006918 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746006919 dimer interface [polypeptide binding]; other site 693746006920 putative CheW interface [polypeptide binding]; other site 693746006921 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693746006922 active site 693746006923 metal binding site [ion binding]; metal-binding site 693746006924 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 693746006925 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 693746006926 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 693746006927 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 693746006928 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 693746006929 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 693746006930 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746006931 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746006932 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746006933 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746006934 Integrase core domain; Region: rve; pfam00665 693746006935 Integrase core domain; Region: rve_3; cl15866 693746006936 HTH-like domain; Region: HTH_21; pfam13276 693746006937 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746006938 Transposase; Region: HTH_Tnp_1; cl17663 693746006939 Predicted membrane protein [Function unknown]; Region: COG3601 693746006940 Sulfatase; Region: Sulfatase; pfam00884 693746006941 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 693746006942 Ligand Binding Site [chemical binding]; other site 693746006943 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 693746006944 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 693746006945 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693746006946 putative active site [active] 693746006947 catalytic site [active] 693746006948 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 693746006949 putative active site [active] 693746006950 catalytic site [active] 693746006951 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 693746006952 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 693746006953 active site 693746006954 Fumble; Region: Fumble; cl17357 693746006955 FeoA domain; Region: FeoA; pfam04023 693746006956 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 693746006957 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693746006958 G1 box; other site 693746006959 GTP/Mg2+ binding site [chemical binding]; other site 693746006960 Switch I region; other site 693746006961 G2 box; other site 693746006962 G3 box; other site 693746006963 Switch II region; other site 693746006964 G4 box; other site 693746006965 G5 box; other site 693746006966 Nucleoside recognition; Region: Gate; pfam07670 693746006967 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693746006968 Nucleoside recognition; Region: Gate; pfam07670 693746006969 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 693746006970 FMN binding site [chemical binding]; other site 693746006971 active site 693746006972 catalytic residues [active] 693746006973 substrate binding site [chemical binding]; other site 693746006974 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 693746006975 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746006976 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746006977 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746006978 DNA binding residues [nucleotide binding] 693746006979 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 693746006980 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 693746006981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746006982 non-specific DNA binding site [nucleotide binding]; other site 693746006983 salt bridge; other site 693746006984 sequence-specific DNA binding site [nucleotide binding]; other site 693746006985 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 693746006986 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u1; cd12826 693746006987 Cl binding site [ion binding]; other site 693746006988 oligomer interface [polypeptide binding]; other site 693746006989 Domain of unknown function (DUF368); Region: DUF368; cl00893 693746006990 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 693746006991 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 693746006992 Walker A/P-loop; other site 693746006993 ATP binding site [chemical binding]; other site 693746006994 Q-loop/lid; other site 693746006995 ABC transporter signature motif; other site 693746006996 Walker B; other site 693746006997 D-loop; other site 693746006998 H-loop/switch region; other site 693746006999 NIL domain; Region: NIL; pfam09383 693746007000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746007001 dimer interface [polypeptide binding]; other site 693746007002 conserved gate region; other site 693746007003 putative PBP binding loops; other site 693746007004 ABC-ATPase subunit interface; other site 693746007005 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 693746007006 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 693746007007 dimer interface [polypeptide binding]; other site 693746007008 active site 693746007009 metal binding site [ion binding]; metal-binding site 693746007010 glutathione binding site [chemical binding]; other site 693746007011 Protein of unknown function (DUF1015); Region: DUF1015; cl19858 693746007012 Uncharacterized conserved protein [Function unknown]; Region: COG2155 693746007013 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 693746007014 pyruvate kinase; Provisional; Region: PRK06354 693746007015 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 693746007016 domain interfaces; other site 693746007017 active site 693746007018 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 693746007019 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 693746007020 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693746007021 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 693746007022 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693746007023 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 693746007024 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 693746007025 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693746007026 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007027 non-specific DNA binding site [nucleotide binding]; other site 693746007028 salt bridge; other site 693746007029 sequence-specific DNA binding site [nucleotide binding]; other site 693746007030 Cupin domain; Region: Cupin_2; pfam07883 693746007031 Integrase core domain; Region: rve_3; cl15866 693746007032 putative transposase OrfB; Reviewed; Region: PHA02517 693746007033 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746007034 active site 693746007035 Protein of unknown function (DUF819); Region: DUF819; cl02317 693746007036 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 693746007037 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746007038 signal recognition particle protein; Provisional; Region: PRK10867 693746007039 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 693746007040 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 693746007041 P loop; other site 693746007042 GTP binding site [chemical binding]; other site 693746007043 Signal peptide binding domain; Region: SRP_SPB; pfam02978 693746007044 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 693746007045 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 693746007046 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 693746007047 RimM N-terminal domain; Region: RimM; pfam01782 693746007048 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 693746007049 aspartate aminotransferase; Provisional; Region: PRK06836 693746007050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746007051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746007052 homodimer interface [polypeptide binding]; other site 693746007053 catalytic residue [active] 693746007054 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 693746007055 core dimer interface [polypeptide binding]; other site 693746007056 peripheral dimer interface [polypeptide binding]; other site 693746007057 L10 interface [polypeptide binding]; other site 693746007058 L11 interface [polypeptide binding]; other site 693746007059 putative EF-Tu interaction site [polypeptide binding]; other site 693746007060 putative EF-G interaction site [polypeptide binding]; other site 693746007061 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 693746007062 23S rRNA interface [nucleotide binding]; other site 693746007063 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 693746007064 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 693746007065 mRNA/rRNA interface [nucleotide binding]; other site 693746007066 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 693746007067 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 693746007068 23S rRNA interface [nucleotide binding]; other site 693746007069 L7/L12 interface [polypeptide binding]; other site 693746007070 putative thiostrepton binding site; other site 693746007071 L25 interface [polypeptide binding]; other site 693746007072 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 693746007073 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 693746007074 putative homodimer interface [polypeptide binding]; other site 693746007075 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 693746007076 heterodimer interface [polypeptide binding]; other site 693746007077 homodimer interface [polypeptide binding]; other site 693746007078 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 693746007079 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 693746007080 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 693746007081 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 693746007082 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746007083 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746007084 threonine synthase; Validated; Region: PRK06260 693746007085 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 693746007086 homodimer interface [polypeptide binding]; other site 693746007087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746007088 catalytic residue [active] 693746007089 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 693746007090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746007091 YheO-like PAS domain; Region: PAS_6; pfam08348 693746007092 HTH domain; Region: HTH_22; pfam13309 693746007093 peptidase; Reviewed; Region: PRK13004 693746007094 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 693746007095 putative metal binding site [ion binding]; other site 693746007096 putative dimer interface [polypeptide binding]; other site 693746007097 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 693746007098 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693746007099 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693746007100 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 693746007101 putative substrate binding site [chemical binding]; other site 693746007102 nucleotide binding site [chemical binding]; other site 693746007103 nucleotide binding site [chemical binding]; other site 693746007104 homodimer interface [polypeptide binding]; other site 693746007105 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 693746007106 putative ligand binding site [chemical binding]; other site 693746007107 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693746007108 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746007109 Walker A/P-loop; other site 693746007110 ATP binding site [chemical binding]; other site 693746007111 Q-loop/lid; other site 693746007112 ABC transporter signature motif; other site 693746007113 Walker B; other site 693746007114 D-loop; other site 693746007115 H-loop/switch region; other site 693746007116 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693746007117 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693746007118 TM-ABC transporter signature motif; other site 693746007119 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693746007120 TM-ABC transporter signature motif; other site 693746007121 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 693746007122 single-stranded DNA-binding protein; Provisional; Region: PRK05813 693746007123 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 693746007124 dimer interface [polypeptide binding]; other site 693746007125 ssDNA binding site [nucleotide binding]; other site 693746007126 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693746007127 methionine sulfoxide reductase A; Provisional; Region: PRK14054 693746007128 methionine sulfoxide reductase B; Provisional; Region: PRK00222 693746007129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746007130 metal binding site [ion binding]; metal-binding site 693746007131 active site 693746007132 I-site; other site 693746007133 Protein of unknown function (DUF342); Region: DUF342; pfam03961 693746007134 Predicted transcriptional regulator [Transcription]; Region: COG1959 693746007135 Rrf2 family protein; Region: rrf2_super; TIGR00738 693746007136 DNA polymerase I; Provisional; Region: PRK05755 693746007137 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 693746007138 active site 693746007139 metal binding site 1 [ion binding]; metal-binding site 693746007140 putative 5' ssDNA interaction site; other site 693746007141 metal binding site 3; metal-binding site 693746007142 metal binding site 2 [ion binding]; metal-binding site 693746007143 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 693746007144 putative DNA binding site [nucleotide binding]; other site 693746007145 putative metal binding site [ion binding]; other site 693746007146 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 693746007147 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 693746007148 active site 693746007149 DNA binding site [nucleotide binding] 693746007150 catalytic site [active] 693746007151 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 693746007152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007153 Coenzyme A binding pocket [chemical binding]; other site 693746007154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007155 Coenzyme A binding pocket [chemical binding]; other site 693746007156 UGMP family protein; Validated; Region: PRK09604 693746007157 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 693746007158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693746007159 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 693746007160 FIC domain binding interface [polypeptide binding]; other site 693746007161 Fic/DOC family; Region: Fic; cl00960 693746007162 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 693746007163 Part of AAA domain; Region: AAA_19; pfam13245 693746007164 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 693746007165 AAA domain; Region: AAA_12; pfam13087 693746007166 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 693746007167 putative active site [active] 693746007168 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 693746007169 Bacteriophage Lambda NinG protein; Region: NinG; pfam05766 693746007170 AAA domain; Region: AAA_25; pfam13481 693746007171 Walker A motif; other site 693746007172 ATP binding site [chemical binding]; other site 693746007173 Walker B motif; other site 693746007174 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 693746007175 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746007176 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746007177 catalytic residues [active] 693746007178 catalytic nucleophile [active] 693746007179 Recombinase; Region: Recombinase; pfam07508 693746007180 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746007181 Adhesion protein FadA; Region: FadA; pfam09403 693746007182 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746007183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746007184 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746007185 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746007186 putative Zn2+ binding site [ion binding]; other site 693746007187 putative DNA binding site [nucleotide binding]; other site 693746007188 BDLF3; Provisional; Region: PHA03255 693746007189 S-layer homology domain; Region: SLH; pfam00395 693746007190 S-layer homology domain; Region: SLH; pfam00395 693746007191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746007192 HTH-like domain; Region: HTH_21; pfam13276 693746007193 Integrase core domain; Region: rve; pfam00665 693746007194 Integrase core domain; Region: rve_3; pfam13683 693746007195 Transposase; Region: HTH_Tnp_1; pfam01527 693746007196 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746007197 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 693746007198 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693746007199 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746007200 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746007201 DNA binding residues [nucleotide binding] 693746007202 PrgI family protein; Region: PrgI; pfam12666 693746007203 Escherichia coli YaeB and related proteins; Region: UPF0066; cl00749 693746007204 cofactor binding site; other site 693746007205 Transposase domain (DUF772); Region: DUF772; pfam05598 693746007206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746007207 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746007208 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693746007209 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693746007210 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693746007211 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693746007212 Ligand binding site [chemical binding]; other site 693746007213 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746007214 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693746007215 FAD binding site [chemical binding]; other site 693746007216 homotetramer interface [polypeptide binding]; other site 693746007217 substrate binding pocket [chemical binding]; other site 693746007218 catalytic base [active] 693746007219 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 693746007220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693746007221 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693746007222 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 693746007223 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693746007224 substrate binding site [chemical binding]; other site 693746007225 oxyanion hole (OAH) forming residues; other site 693746007226 trimer interface [polypeptide binding]; other site 693746007227 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693746007228 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746007229 dimer interface [polypeptide binding]; other site 693746007230 PYR/PP interface [polypeptide binding]; other site 693746007231 TPP binding site [chemical binding]; other site 693746007232 substrate binding site [chemical binding]; other site 693746007233 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693746007234 Domain of unknown function; Region: EKR; smart00890 693746007235 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746007236 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 693746007237 TPP-binding site [chemical binding]; other site 693746007238 aspartate aminotransferase; Provisional; Region: PRK05764 693746007239 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746007240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746007241 homodimer interface [polypeptide binding]; other site 693746007242 catalytic residue [active] 693746007243 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 693746007244 Transcriptional regulator [Transcription]; Region: IclR; COG1414 693746007245 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 693746007246 Bacterial transcriptional regulator; Region: IclR; pfam01614 693746007247 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746007248 LytTr DNA-binding domain; Region: LytTR; smart00850 693746007249 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746007250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746007251 Walker A/P-loop; other site 693746007252 ATP binding site [chemical binding]; other site 693746007253 Q-loop/lid; other site 693746007254 ABC transporter signature motif; other site 693746007255 Walker B; other site 693746007256 D-loop; other site 693746007257 H-loop/switch region; other site 693746007258 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693746007259 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 693746007260 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746007261 MarR family; Region: MarR_2; pfam12802 693746007262 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746007263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746007264 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746007265 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746007266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746007267 Walker A/P-loop; other site 693746007268 ATP binding site [chemical binding]; other site 693746007269 Q-loop/lid; other site 693746007270 ABC transporter signature motif; other site 693746007271 Walker B; other site 693746007272 D-loop; other site 693746007273 H-loop/switch region; other site 693746007274 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746007275 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746007276 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 693746007277 Walker A/P-loop; other site 693746007278 ATP binding site [chemical binding]; other site 693746007279 Q-loop/lid; other site 693746007280 ABC transporter signature motif; other site 693746007281 Walker B; other site 693746007282 D-loop; other site 693746007283 H-loop/switch region; other site 693746007284 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 693746007285 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 693746007286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693746007287 Histidine kinase; Region: His_kinase; pfam06580 693746007288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746007289 ATP binding site [chemical binding]; other site 693746007290 Mg2+ binding site [ion binding]; other site 693746007291 G-X-G motif; other site 693746007292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746007293 active site 693746007294 phosphorylation site [posttranslational modification] 693746007295 intermolecular recognition site; other site 693746007296 dimerization interface [polypeptide binding]; other site 693746007297 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 693746007298 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 693746007299 S-layer homology domain; Region: SLH; pfam00395 693746007300 S-layer homology domain; Region: SLH; pfam00395 693746007301 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 693746007302 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 693746007303 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693746007304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746007305 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746007306 WHG domain; Region: WHG; pfam13305 693746007307 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746007308 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746007309 catalytic residues [active] 693746007310 catalytic nucleophile [active] 693746007311 Recombinase; Region: Recombinase; pfam07508 693746007312 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746007313 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746007314 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 693746007315 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 693746007316 oxalacetate binding site [chemical binding]; other site 693746007317 citrylCoA binding site [chemical binding]; other site 693746007318 coenzyme A binding site [chemical binding]; other site 693746007319 catalytic triad [active] 693746007320 NAD-dependent deacetylase; Provisional; Region: PRK00481 693746007321 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 693746007322 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 693746007323 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746007324 FeS/SAM binding site; other site 693746007325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 693746007326 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 693746007327 putative transposase OrfB; Reviewed; Region: PHA02517 693746007328 Integrase core domain; Region: rve; pfam00665 693746007329 Integrase core domain; Region: rve_3; cl15866 693746007330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746007331 Transposase; Region: HTH_Tnp_1; cl17663 693746007332 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 693746007333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746007334 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693746007335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746007336 DNA binding residues [nucleotide binding] 693746007337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746007338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746007339 ATP binding site [chemical binding]; other site 693746007340 Mg2+ binding site [ion binding]; other site 693746007341 G-X-G motif; other site 693746007342 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 693746007343 anti sigma factor interaction site; other site 693746007344 regulatory phosphorylation site [posttranslational modification]; other site 693746007345 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 693746007346 putative substrate binding site [chemical binding]; other site 693746007347 putative ATP binding site [chemical binding]; other site 693746007348 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746007349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 693746007350 DNA binding residues [nucleotide binding] 693746007351 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746007352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746007353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746007354 transposase/IS protein; Provisional; Region: PRK09183 693746007355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746007356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746007357 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746007358 dimerization interface [polypeptide binding]; other site 693746007359 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746007360 EamA-like transporter family; Region: EamA; pfam00892 693746007361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746007362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746007363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746007364 dimerization interface [polypeptide binding]; other site 693746007365 S-layer homology domain; Region: SLH; pfam00395 693746007366 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 693746007367 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 693746007368 active site 693746007369 Zn binding site [ion binding]; other site 693746007370 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693746007371 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693746007372 Predicted integral membrane protein [Function unknown]; Region: COG5505 693746007373 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 693746007374 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 693746007375 active site 693746007376 dipeptidase PepV; Reviewed; Region: PRK07318 693746007377 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 693746007378 active site 693746007379 metal binding site [ion binding]; metal-binding site 693746007380 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 693746007381 putative oxidoreductase; Provisional; Region: PRK12831 693746007382 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 693746007383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746007384 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 693746007385 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 693746007386 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 693746007387 FAD binding pocket [chemical binding]; other site 693746007388 FAD binding motif [chemical binding]; other site 693746007389 phosphate binding motif [ion binding]; other site 693746007390 beta-alpha-beta structure motif; other site 693746007391 NAD binding pocket [chemical binding]; other site 693746007392 Iron coordination center [ion binding]; other site 693746007393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693746007394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693746007395 ligand binding site [chemical binding]; other site 693746007396 flexible hinge region; other site 693746007397 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693746007398 FOG: CBS domain [General function prediction only]; Region: COG0517 693746007399 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 693746007400 Integrase core domain; Region: rve; pfam00665 693746007401 Integrase core domain; Region: rve_3; cl15866 693746007402 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693746007403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746007404 ABC transporter; Region: ABC_tran_2; pfam12848 693746007405 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746007406 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693746007407 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693746007408 active site 693746007409 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 693746007410 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 693746007411 intersubunit interface [polypeptide binding]; other site 693746007412 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 693746007413 MgtC family; Region: MgtC; pfam02308 693746007414 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 693746007415 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 693746007416 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 693746007417 Glycoprotease family; Region: Peptidase_M22; pfam00814 693746007418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746007419 active site 693746007420 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693746007421 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 693746007422 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 693746007423 trimer interface [polypeptide binding]; other site 693746007424 putative metal binding site [ion binding]; other site 693746007425 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 693746007426 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 693746007427 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 693746007428 metal ion-dependent adhesion site (MIDAS); other site 693746007429 MoxR-like ATPases [General function prediction only]; Region: COG0714 693746007430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746007431 Walker A motif; other site 693746007432 ATP binding site [chemical binding]; other site 693746007433 Walker B motif; other site 693746007434 arginine finger; other site 693746007435 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 693746007436 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 693746007437 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 693746007438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693746007439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746007440 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746007441 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746007442 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746007443 catalytic loop [active] 693746007444 iron binding site [ion binding]; other site 693746007445 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 693746007446 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 693746007447 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693746007448 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 693746007449 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 693746007450 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 693746007451 homotrimer interaction site [polypeptide binding]; other site 693746007452 putative active site [active] 693746007453 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 693746007454 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 693746007455 beta and beta' interface [polypeptide binding]; other site 693746007456 beta' and sigma factor interface [polypeptide binding]; other site 693746007457 Zn-binding [ion binding]; other site 693746007458 active site region [active] 693746007459 catalytic site [active] 693746007460 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 693746007461 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 693746007462 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 693746007463 G-loop; other site 693746007464 DNA binding site [nucleotide binding] 693746007465 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 693746007466 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 693746007467 RPB12 interaction site [polypeptide binding]; other site 693746007468 RPB1 interaction site [polypeptide binding]; other site 693746007469 RPB10 interaction site [polypeptide binding]; other site 693746007470 RPB11 interaction site [polypeptide binding]; other site 693746007471 RPB3 interaction site [polypeptide binding]; other site 693746007472 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 693746007473 D-serine dehydratase; Provisional; Region: PRK02991 693746007474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746007475 catalytic residue [active] 693746007476 Cache domain; Region: Cache_1; pfam02743 693746007477 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746007478 dimer interface [polypeptide binding]; other site 693746007479 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746007480 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746007481 dimer interface [polypeptide binding]; other site 693746007482 putative CheW interface [polypeptide binding]; other site 693746007483 GTP-binding protein YchF; Reviewed; Region: PRK09601 693746007484 YchF GTPase; Region: YchF; cd01900 693746007485 G1 box; other site 693746007486 GTP/Mg2+ binding site [chemical binding]; other site 693746007487 Switch I region; other site 693746007488 G2 box; other site 693746007489 Switch II region; other site 693746007490 G3 box; other site 693746007491 G4 box; other site 693746007492 G5 box; other site 693746007493 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 693746007494 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746007495 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746007496 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 693746007497 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 693746007498 active site 693746007499 HIGH motif; other site 693746007500 KMSKS motif; other site 693746007501 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 693746007502 tRNA binding surface [nucleotide binding]; other site 693746007503 Oligomerization domain; Region: Oligomerization; pfam02410 693746007504 Transcriptional regulator [Transcription]; Region: LytR; COG1316 693746007505 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 693746007506 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 693746007507 active site 693746007508 (T/H)XGH motif; other site 693746007509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746007510 Zn2+ binding site [ion binding]; other site 693746007511 Mg2+ binding site [ion binding]; other site 693746007512 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 693746007513 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 693746007514 active site 693746007515 dimerization interface [polypeptide binding]; other site 693746007516 ribonuclease PH; Reviewed; Region: rph; PRK00173 693746007517 Ribonuclease PH; Region: RNase_PH_bact; cd11362 693746007518 hexamer interface [polypeptide binding]; other site 693746007519 active site 693746007520 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 693746007521 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 693746007522 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 693746007523 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 693746007524 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 693746007525 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693746007526 Walker A/P-loop; other site 693746007527 ATP binding site [chemical binding]; other site 693746007528 Q-loop/lid; other site 693746007529 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 693746007530 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 693746007531 ABC transporter signature motif; other site 693746007532 Walker B; other site 693746007533 D-loop; other site 693746007534 H-loop/switch region; other site 693746007535 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746007536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007537 non-specific DNA binding site [nucleotide binding]; other site 693746007538 salt bridge; other site 693746007539 sequence-specific DNA binding site [nucleotide binding]; other site 693746007540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746007541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007542 non-specific DNA binding site [nucleotide binding]; other site 693746007543 salt bridge; other site 693746007544 sequence-specific DNA binding site [nucleotide binding]; other site 693746007545 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 693746007546 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 693746007547 non-heme iron binding site [ion binding]; other site 693746007548 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 693746007549 active site 693746007550 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 693746007551 nucleotide binding site [chemical binding]; other site 693746007552 homotetrameric interface [polypeptide binding]; other site 693746007553 putative phosphate binding site [ion binding]; other site 693746007554 putative allosteric binding site; other site 693746007555 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 693746007556 putative catalytic cysteine [active] 693746007557 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 693746007558 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 693746007559 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 693746007560 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 693746007561 putative metal binding residues [ion binding]; other site 693746007562 signature motif; other site 693746007563 dimer interface [polypeptide binding]; other site 693746007564 active site 693746007565 polyP binding site; other site 693746007566 substrate binding site [chemical binding]; other site 693746007567 acceptor-phosphate pocket; other site 693746007568 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 693746007569 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746007570 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746007571 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693746007572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007573 Coenzyme A binding pocket [chemical binding]; other site 693746007574 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 693746007575 active site 693746007576 catalytic residues [active] 693746007577 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693746007578 cofactor binding site; other site 693746007579 DNA binding site [nucleotide binding] 693746007580 substrate interaction site [chemical binding]; other site 693746007581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007582 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746007583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746007584 active site 693746007585 phosphorylation site [posttranslational modification] 693746007586 intermolecular recognition site; other site 693746007587 dimerization interface [polypeptide binding]; other site 693746007588 LytTr DNA-binding domain; Region: LytTR; cl04498 693746007589 GHKL domain; Region: HATPase_c_5; pfam14501 693746007590 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 693746007591 S-layer homology domain; Region: SLH; pfam00395 693746007592 S-layer homology domain; Region: SLH; pfam00395 693746007593 S-layer homology domain; Region: SLH; pfam00395 693746007594 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693746007595 ParB-like nuclease domain; Region: ParBc; pfam02195 693746007596 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746007597 AAA domain; Region: AAA_23; pfam13476 693746007598 Walker A/P-loop; other site 693746007599 ATP binding site [chemical binding]; other site 693746007600 AAA domain; Region: AAA_21; pfam13304 693746007601 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 693746007602 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 693746007603 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 693746007604 Maff2 family; Region: Maff2; pfam12750 693746007605 PrgI family protein; Region: PrgI; pfam12666 693746007606 AAA-like domain; Region: AAA_10; pfam12846 693746007607 Domain of unknown function DUF87; Region: DUF87; cl19135 693746007608 NlpC/P60 family; Region: NLPC_P60; pfam00877 693746007609 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 693746007610 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 693746007611 DNA topoisomerase III; Provisional; Region: PRK07726 693746007612 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 693746007613 active site 693746007614 putative interdomain interaction site [polypeptide binding]; other site 693746007615 putative metal-binding site [ion binding]; other site 693746007616 putative nucleotide binding site [chemical binding]; other site 693746007617 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 693746007618 domain I; other site 693746007619 DNA binding groove [nucleotide binding] 693746007620 phosphate binding site [ion binding]; other site 693746007621 domain II; other site 693746007622 domain III; other site 693746007623 nucleotide binding site [chemical binding]; other site 693746007624 catalytic site [active] 693746007625 domain IV; other site 693746007626 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 693746007627 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 693746007628 YodL-like; Region: YodL; pfam14191 693746007629 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 693746007630 Domain of unknown function (DUF4319); Region: DUF4319; pfam14203 693746007631 Restriction endonuclease BamHI; Region: BamHI; pfam02923 693746007632 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746007633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007634 non-specific DNA binding site [nucleotide binding]; other site 693746007635 salt bridge; other site 693746007636 sequence-specific DNA binding site [nucleotide binding]; other site 693746007637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746007638 DNA methylase; Region: N6_N4_Mtase; pfam01555 693746007639 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693746007640 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 693746007641 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 693746007642 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693746007643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746007644 ATP binding site [chemical binding]; other site 693746007645 putative Mg++ binding site [ion binding]; other site 693746007646 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 693746007647 helicase superfamily c-terminal domain; Region: HELICc; smart00490 693746007648 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 693746007649 Protein of unknown function (DUF3849); Region: DUF3849; pfam12960 693746007650 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746007651 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693746007652 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693746007653 ligand binding site [chemical binding]; other site 693746007654 flexible hinge region; other site 693746007655 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 693746007656 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 693746007657 methionine aminopeptidase; Provisional; Region: PRK12318 693746007658 SEC-C motif; Region: SEC-C; pfam02810 693746007659 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 693746007660 active site 693746007661 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746007662 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746007663 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746007664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746007665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746007666 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746007667 dimerization interface [polypeptide binding]; other site 693746007668 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 693746007669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746007670 Walker A/P-loop; other site 693746007671 ATP binding site [chemical binding]; other site 693746007672 Q-loop/lid; other site 693746007673 ABC transporter signature motif; other site 693746007674 Walker B; other site 693746007675 D-loop; other site 693746007676 H-loop/switch region; other site 693746007677 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 693746007678 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 693746007679 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 693746007680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746007681 putative substrate translocation pore; other site 693746007682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746007683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007684 non-specific DNA binding site [nucleotide binding]; other site 693746007685 salt bridge; other site 693746007686 sequence-specific DNA binding site [nucleotide binding]; other site 693746007687 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746007688 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; cl17893 693746007689 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746007690 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746007691 catalytic residues [active] 693746007692 catalytic nucleophile [active] 693746007693 Recombinase; Region: Recombinase; pfam07508 693746007694 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746007695 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746007696 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746007697 catalytic residues [active] 693746007698 catalytic nucleophile [active] 693746007699 Recombinase; Region: Recombinase; pfam07508 693746007700 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746007701 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746007702 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746007703 catalytic residues [active] 693746007704 catalytic nucleophile [active] 693746007705 Recombinase; Region: Recombinase; pfam07508 693746007706 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746007707 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746007708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007709 non-specific DNA binding site [nucleotide binding]; other site 693746007710 salt bridge; other site 693746007711 sequence-specific DNA binding site [nucleotide binding]; other site 693746007712 Domain of unknown function (DUF955); Region: DUF955; cl01076 693746007713 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746007714 active site 693746007715 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 693746007716 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 693746007717 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746007718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007719 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 693746007720 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746007721 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746007722 Int/Topo IB signature motif; other site 693746007723 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746007724 Sel1-like repeats; Region: SEL1; smart00671 693746007725 Sel1 repeat; Region: Sel1; pfam08238 693746007726 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746007727 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746007728 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746007729 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 693746007730 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 693746007731 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746007732 ATP-binding site [chemical binding]; other site 693746007733 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 693746007734 additional DNA contacts [nucleotide binding]; other site 693746007735 mismatch recognition site; other site 693746007736 active site 693746007737 zinc binding site [ion binding]; other site 693746007738 DNA intercalation site [nucleotide binding]; other site 693746007739 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693746007740 active site 693746007741 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746007742 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746007743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007744 non-specific DNA binding site [nucleotide binding]; other site 693746007745 salt bridge; other site 693746007746 sequence-specific DNA binding site [nucleotide binding]; other site 693746007747 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746007748 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746007749 Homeodomain-like domain; Region: HTH_32; pfam13565 693746007750 Integrase core domain; Region: rve; pfam00665 693746007751 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 693746007752 Chloramphenicol acetyltransferase; Region: CAT; cl02008 693746007753 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 693746007754 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693746007755 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 693746007756 active site 693746007757 catalytic residues [active] 693746007758 metal binding site [ion binding]; metal-binding site 693746007759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746007760 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 693746007761 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 693746007762 nudix motif; other site 693746007763 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 693746007764 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693746007765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746007766 motif II; other site 693746007767 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 693746007768 thiamine phosphate binding site [chemical binding]; other site 693746007769 active site 693746007770 pyrophosphate binding site [ion binding]; other site 693746007771 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 693746007772 Na binding site [ion binding]; other site 693746007773 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 693746007774 dimer interface [polypeptide binding]; other site 693746007775 substrate binding site [chemical binding]; other site 693746007776 ATP binding site [chemical binding]; other site 693746007777 Thiamine pyrophosphokinase; Region: TPK; cd07995 693746007778 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 693746007779 active site 693746007780 dimerization interface [polypeptide binding]; other site 693746007781 thiamine binding site [chemical binding]; other site 693746007782 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 693746007783 Integrase core domain; Region: rve; pfam00665 693746007784 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693746007785 tetramer interface [polypeptide binding]; other site 693746007786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746007787 catalytic residue [active] 693746007788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746007789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746007790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746007791 dimerization interface [polypeptide binding]; other site 693746007792 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 693746007793 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 693746007794 Flavodoxins [Energy production and conversion]; Region: FldA; COG0716 693746007795 Ferredoxin [Energy production and conversion]; Region: COG1146 693746007796 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 693746007797 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693746007798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746007799 non-specific DNA binding site [nucleotide binding]; other site 693746007800 salt bridge; other site 693746007801 sequence-specific DNA binding site [nucleotide binding]; other site 693746007802 Cupin domain; Region: Cupin_2; pfam07883 693746007803 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746007804 EamA-like transporter family; Region: EamA; pfam00892 693746007805 EamA-like transporter family; Region: EamA; pfam00892 693746007806 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 693746007807 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 693746007808 S-layer homology domain; Region: SLH; pfam00395 693746007809 S-layer homology domain; Region: SLH; pfam00395 693746007810 S-layer homology domain; Region: SLH; pfam00395 693746007811 potential frameshift: common BLAST hit: gi|317057226|ref|YP_004105693.1| DNA repair ATPase 693746007812 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746007813 Walker B; other site 693746007814 D-loop; other site 693746007815 H-loop/switch region; other site 693746007816 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 693746007817 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 693746007818 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746007819 Fic family protein [Function unknown]; Region: COG3177 693746007820 Fic/DOC family; Region: Fic; pfam02661 693746007821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 693746007822 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746007823 dimerization interface [polypeptide binding]; other site 693746007824 putative Zn2+ binding site [ion binding]; other site 693746007825 putative DNA binding site [nucleotide binding]; other site 693746007826 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 693746007827 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693746007828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746007829 Walker A/P-loop; other site 693746007830 ATP binding site [chemical binding]; other site 693746007831 Q-loop/lid; other site 693746007832 ABC transporter signature motif; other site 693746007833 Walker B; other site 693746007834 D-loop; other site 693746007835 H-loop/switch region; other site 693746007836 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746007837 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746007838 DNA binding residues [nucleotide binding] 693746007839 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746007840 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746007841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746007842 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 693746007843 Putative amidase domain; Region: Amidase_6; pfam12671 693746007844 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746007845 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746007846 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746007847 transposase/IS protein; Provisional; Region: PRK09183 693746007848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746007849 Walker A motif; other site 693746007850 ATP binding site [chemical binding]; other site 693746007851 Walker B motif; other site 693746007852 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746007853 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746007854 Integrase core domain; Region: rve; pfam00665 693746007855 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746007856 Putative amidase domain; Region: Amidase_6; pfam12671 693746007857 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746007858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746007859 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 693746007860 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746007861 RNA polymerase sigma factor; Provisional; Region: PRK11924 693746007862 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746007863 DNA binding residues [nucleotide binding] 693746007864 Transposon-encoded protein TnpW; Region: TnpW; pfam14202 693746007865 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746007866 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746007867 catalytic residues [active] 693746007868 catalytic nucleophile [active] 693746007869 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746007870 RNA polymerase sigma factor; Provisional; Region: PRK11924 693746007871 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746007872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746007873 DNA binding residues [nucleotide binding] 693746007874 Snf7; Region: Snf7; cl19390 693746007875 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 693746007876 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 693746007877 MMPL family; Region: MMPL; cl14618 693746007878 MMPL family; Region: MMPL; cl14618 693746007879 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 693746007880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746007881 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 693746007882 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746007883 Putative transposase; Region: Y2_Tnp; pfam04986 693746007884 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746007885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007886 active site 693746007887 DNA binding site [nucleotide binding] 693746007888 Int/Topo IB signature motif; other site 693746007889 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 693746007890 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746007891 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746007892 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746007893 Integrase core domain; Region: rve; pfam00665 693746007894 Integrase core domain; Region: rve_3; cl15866 693746007895 HTH-like domain; Region: HTH_21; pfam13276 693746007896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746007897 Transposase; Region: HTH_Tnp_1; cl17663 693746007898 BCCT family transporter; Region: BCCT; pfam02028 693746007899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746007900 HTH-like domain; Region: HTH_21; pfam13276 693746007901 Integrase core domain; Region: rve; pfam00665 693746007902 Integrase core domain; Region: rve_3; pfam13683 693746007903 Transposase; Region: HTH_Tnp_1; pfam01527 693746007904 potential frameshift: common BLAST hit: gi|237794099|ref|YP_002861651.1| tyrosine recombinase XerC 693746007905 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007906 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007907 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746007908 transposase/IS protein; Provisional; Region: PRK09183 693746007909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746007910 Walker A motif; other site 693746007911 ATP binding site [chemical binding]; other site 693746007912 Walker B motif; other site 693746007913 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746007914 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746007915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746007916 Integrase core domain; Region: rve; pfam00665 693746007917 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; cl17873 693746007918 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007919 active site 693746007920 DNA binding site [nucleotide binding] 693746007921 Int/Topo IB signature motif; other site 693746007922 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746007923 Putative transposase; Region: Y2_Tnp; pfam04986 693746007924 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693746007925 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746007926 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746007927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746007928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746007929 hypothetical protein; Provisional; Region: PRK07877 693746007930 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 693746007931 GIY-YIG motif/motif A; other site 693746007932 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 693746007933 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746007934 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007935 active site 693746007936 DNA binding site [nucleotide binding] 693746007937 Int/Topo IB signature motif; other site 693746007938 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746007939 Putative transposase; Region: Y2_Tnp; pfam04986 693746007940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746007941 Walker A/P-loop; other site 693746007942 ATP binding site [chemical binding]; other site 693746007943 Q-loop/lid; other site 693746007944 ABC transporter signature motif; other site 693746007945 Walker B; other site 693746007946 D-loop; other site 693746007947 H-loop/switch region; other site 693746007948 chromosome segregation protein; Provisional; Region: PRK03918 693746007949 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746007950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746007951 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746007952 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746007953 Helix-turn-helix domain; Region: HTH_17; cl17695 693746007954 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 693746007955 Helicase conserved C-terminal domain; Region: Helicase_C; cl17351 693746007956 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746007957 Fic family protein [Function unknown]; Region: COG3177 693746007958 Fic/DOC family; Region: Fic; pfam02661 693746007959 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 693746007960 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746007961 putative DNA binding site [nucleotide binding]; other site 693746007962 putative Zn2+ binding site [ion binding]; other site 693746007963 WYL domain; Region: WYL; pfam13280 693746007964 WYL domain; Region: WYL; pfam13280 693746007965 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 693746007966 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 693746007967 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 693746007968 Predicted choloylglycine hydrolase [General function prediction only]; Region: COG4927 693746007969 active site 693746007970 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 693746007971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007972 Coenzyme A binding pocket [chemical binding]; other site 693746007973 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746007974 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693746007975 active site 693746007976 catalytic residues [active] 693746007977 DNA binding site [nucleotide binding] 693746007978 Int/Topo IB signature motif; other site 693746007979 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746007980 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693746007981 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693746007982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007983 Coenzyme A binding pocket [chemical binding]; other site 693746007984 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 693746007985 hydrophobic ligand binding site; other site 693746007986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007987 Coenzyme A binding pocket [chemical binding]; other site 693746007988 YoaP-like; Region: YoaP; pfam14268 693746007989 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 693746007990 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 693746007991 trimer interface [polypeptide binding]; other site 693746007992 active site 693746007993 substrate binding site [chemical binding]; other site 693746007994 CoA binding site [chemical binding]; other site 693746007995 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 693746007996 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693746007997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746007998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746007999 Coenzyme A binding pocket [chemical binding]; other site 693746008000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746008001 Coenzyme A binding pocket [chemical binding]; other site 693746008002 YoaP-like; Region: YoaP; pfam14268 693746008003 Flavodoxin domain; Region: Flavodoxin_5; cl17428 693746008004 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 693746008005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746008006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 693746008007 Recombinase; Region: Recombinase; pfam07508 693746008008 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746008009 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746008010 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746008011 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 693746008012 putative catalytic residues [active] 693746008013 catalytic nucleophile [active] 693746008014 Recombinase; Region: Recombinase; pfam07508 693746008015 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746008016 Mitochondrial ribosomal protein L28; Region: MRP-L28; pfam09812 693746008017 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746008018 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746008019 Snf7; Region: Snf7; cl19390 693746008020 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 693746008021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746008022 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746008023 DNA binding residues [nucleotide binding] 693746008024 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 693746008025 VanZ like family; Region: VanZ; cl01971 693746008026 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746008027 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746008028 catalytic residues [active] 693746008029 catalytic nucleophile [active] 693746008030 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746008031 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693746008032 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746008033 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 693746008034 potential frameshift: common BLAST hit: gi|347532995|ref|YP_004839758.1| Relaxase/mobilization nuclease family protein 693746008035 potential frameshift: common BLAST hit: gi|302384720|ref|YP_003820542.1| Relaxase/mobilization nuclease family protein 693746008036 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746008037 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746008038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746008039 non-specific DNA binding site [nucleotide binding]; other site 693746008040 salt bridge; other site 693746008041 sequence-specific DNA binding site [nucleotide binding]; other site 693746008042 Domain of unknown function (DUF4316); Region: DUF4316; pfam14195 693746008043 Cysteine-rich VLP; Region: Cys_rich_VLP; pfam14194 693746008044 Domain of unknown function (DUF4366); Region: DUF4366; pfam14283 693746008045 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 693746008046 PrgI family protein; Region: PrgI; pfam12666 693746008047 MT-A70; Region: MT-A70; cl01947 693746008048 DNA methylase; Region: N6_N4_Mtase; pfam01555 693746008049 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 693746008050 Maff2 family; Region: Maff2; pfam12750 693746008051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746008052 HTH-like domain; Region: HTH_21; pfam13276 693746008053 Integrase core domain; Region: rve; pfam00665 693746008054 Integrase core domain; Region: rve_3; pfam13683 693746008055 Transposase; Region: HTH_Tnp_1; pfam01527 693746008056 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746008057 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746008058 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746008059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746008060 Walker A/P-loop; other site 693746008061 ATP binding site [chemical binding]; other site 693746008062 Q-loop/lid; other site 693746008063 ABC transporter signature motif; other site 693746008064 Walker B; other site 693746008065 D-loop; other site 693746008066 H-loop/switch region; other site 693746008067 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746008068 HTH-like domain; Region: HTH_21; pfam13276 693746008069 Integrase core domain; Region: rve; pfam00665 693746008070 Putative amidase domain; Region: Amidase_6; pfam12671 693746008071 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 693746008072 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 693746008073 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 693746008074 conserved cys residue [active] 693746008075 Predicted transcriptional regulator [Transcription]; Region: COG2378 693746008076 HTH domain; Region: HTH_11; pfam08279 693746008077 WYL domain; Region: WYL; pfam13280 693746008078 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 693746008079 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 693746008080 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746008081 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746008082 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746008083 DNA binding residues [nucleotide binding] 693746008084 Putative zinc-finger; Region: zf-HC2; pfam13490 693746008085 Chloramphenicol acetyltransferase; Region: CAT; cl02008 693746008086 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693746008087 YoaP-like; Region: YoaP; pfam14268 693746008088 Phospholipid methyltransferase; Region: PEMT; cl17370 693746008089 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746008090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746008091 ABC transporter signature motif; other site 693746008092 Walker B; other site 693746008093 D-loop; other site 693746008094 H-loop/switch region; other site 693746008095 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 693746008096 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746008097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746008098 DNA binding residues [nucleotide binding] 693746008099 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 693746008100 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 693746008101 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746008102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746008103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746008104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746008105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746008106 non-specific DNA binding site [nucleotide binding]; other site 693746008107 salt bridge; other site 693746008108 sequence-specific DNA binding site [nucleotide binding]; other site 693746008109 HTH-like domain; Region: HTH_21; pfam13276 693746008110 Integrase core domain; Region: rve; pfam00665 693746008111 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 693746008112 active site 693746008113 metal binding site [ion binding]; metal-binding site 693746008114 homotetramer interface [polypeptide binding]; other site 693746008115 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 693746008116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746008117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746008118 non-specific DNA binding site [nucleotide binding]; other site 693746008119 salt bridge; other site 693746008120 sequence-specific DNA binding site [nucleotide binding]; other site 693746008121 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746008122 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746008123 Homeodomain-like domain; Region: HTH_32; pfam13565 693746008124 Integrase core domain; Region: rve; pfam00665 693746008125 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746008126 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008127 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746008128 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 693746008129 DNA binding residues [nucleotide binding] 693746008130 dimer interface [polypeptide binding]; other site 693746008131 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 693746008132 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 693746008133 Malic enzyme, N-terminal domain; Region: malic; pfam00390 693746008134 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 693746008135 putative NAD(P) binding site [chemical binding]; other site 693746008136 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 693746008137 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 693746008138 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746008139 putative active site [active] 693746008140 heme pocket [chemical binding]; other site 693746008141 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 693746008142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746008143 ATP binding site [chemical binding]; other site 693746008144 Mg2+ binding site [ion binding]; other site 693746008145 G-X-G motif; other site 693746008146 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 693746008147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746008148 active site 693746008149 phosphorylation site [posttranslational modification] 693746008150 intermolecular recognition site; other site 693746008151 dimerization interface [polypeptide binding]; other site 693746008152 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746008153 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 693746008154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746008155 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693746008156 FeS/SAM binding site; other site 693746008157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 693746008158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746008159 Radical SAM superfamily; Region: Radical_SAM; pfam04055 693746008160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746008161 FeS/SAM binding site; other site 693746008162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746008163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746008164 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 693746008165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746008166 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 693746008167 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 693746008168 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693746008169 catalytic residue [active] 693746008170 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 693746008171 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693746008172 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693746008173 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693746008174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693746008175 inhibitor-cofactor binding pocket; inhibition site 693746008176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746008177 catalytic residue [active] 693746008178 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 693746008179 homohexameric interface [polypeptide binding]; other site 693746008180 feedback inhibition sensing region; other site 693746008181 nucleotide binding site [chemical binding]; other site 693746008182 N-acetyl-L-glutamate binding site [chemical binding]; other site 693746008183 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 693746008184 heterotetramer interface [polypeptide binding]; other site 693746008185 active site pocket [active] 693746008186 cleavage site 693746008187 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 693746008188 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 693746008189 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 693746008190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746008191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746008192 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746008193 dimerization interface [polypeptide binding]; other site 693746008194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746008195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746008196 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 693746008197 putative transposase OrfB; Reviewed; Region: PHA02517 693746008198 Integrase core domain; Region: rve; pfam00665 693746008199 Integrase core domain; Region: rve_3; cl15866 693746008200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746008201 Transposase; Region: HTH_Tnp_1; cl17663 693746008202 DctM-like transporters; Region: DctM; pfam06808 693746008203 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746008204 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 693746008205 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746008206 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746008207 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 693746008208 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 693746008209 active site 693746008210 FMN binding site [chemical binding]; other site 693746008211 substrate binding site [chemical binding]; other site 693746008212 putative catalytic residue [active] 693746008213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746008214 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 693746008215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746008216 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693746008217 FAD binding site [chemical binding]; other site 693746008218 homotetramer interface [polypeptide binding]; other site 693746008219 substrate binding pocket [chemical binding]; other site 693746008220 catalytic base [active] 693746008221 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 693746008222 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693746008223 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693746008224 Predicted permeases [General function prediction only]; Region: COG0679 693746008225 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 693746008226 Cupin domain; Region: Cupin_2; pfam07883 693746008227 Coenzyme A transferase; Region: CoA_trans; cl17247 693746008228 Coenzyme A transferase; Region: CoA_trans; cl17247 693746008229 Coenzyme A transferase; Region: CoA_trans; cl17247 693746008230 PAS domain; Region: PAS_9; pfam13426 693746008231 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 693746008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746008233 Walker A motif; other site 693746008234 ATP binding site [chemical binding]; other site 693746008235 Walker B motif; other site 693746008236 arginine finger; other site 693746008237 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693746008238 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 693746008239 catalytic residues [active] 693746008240 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 693746008241 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 693746008242 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 693746008243 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746008244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746008245 homodimer interface [polypeptide binding]; other site 693746008246 catalytic residue [active] 693746008247 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693746008248 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 693746008249 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 693746008250 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 693746008251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746008252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746008253 homodimer interface [polypeptide binding]; other site 693746008254 catalytic residue [active] 693746008255 Restriction endonuclease; Region: Mrr_cat; cl19295 693746008256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746008257 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 693746008258 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 693746008259 NAD binding site [chemical binding]; other site 693746008260 ligand binding site [chemical binding]; other site 693746008261 catalytic site [active] 693746008262 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 693746008263 dimer interface [polypeptide binding]; other site 693746008264 active site 693746008265 metal binding site [ion binding]; metal-binding site 693746008266 HTH-like domain; Region: HTH_21; pfam13276 693746008267 Integrase core domain; Region: rve; pfam00665 693746008268 Integrase core domain; Region: rve_2; pfam13333 693746008269 prolyl-tRNA synthetase; Provisional; Region: PRK08661 693746008270 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 693746008271 dimer interface [polypeptide binding]; other site 693746008272 motif 1; other site 693746008273 active site 693746008274 motif 2; other site 693746008275 motif 3; other site 693746008276 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 693746008277 anticodon binding site; other site 693746008278 zinc-binding site [ion binding]; other site 693746008279 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746008280 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746008281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746008282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746008283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746008284 dimerization interface [polypeptide binding]; other site 693746008285 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 693746008286 homodimer interface [polypeptide binding]; other site 693746008287 substrate-cofactor binding pocket; other site 693746008288 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746008289 catalytic residue [active] 693746008290 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 693746008291 tetramer (dimer of dimers) interface [polypeptide binding]; other site 693746008292 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 693746008293 NAD binding site [chemical binding]; other site 693746008294 dimer interface [polypeptide binding]; other site 693746008295 substrate binding site [chemical binding]; other site 693746008296 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 693746008297 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 693746008298 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 693746008299 iron binding site [ion binding]; other site 693746008300 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 693746008301 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746008302 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 693746008303 active site 693746008304 putative hydratase; Provisional; Region: PRK11413 693746008305 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 693746008306 substrate binding site [chemical binding]; other site 693746008307 ligand binding site [chemical binding]; other site 693746008308 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 693746008309 substrate binding site [chemical binding]; other site 693746008310 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 693746008311 TIGR04255 family protein; Region: sporadTIGR04255 693746008312 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 693746008313 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 693746008314 cysteine synthase; Region: PLN02565 693746008315 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 693746008316 dimer interface [polypeptide binding]; other site 693746008317 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746008318 catalytic residue [active] 693746008319 hypothetical protein; Provisional; Region: PRK10621 693746008320 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 693746008321 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 693746008322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693746008323 active site 693746008324 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693746008325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746008326 motif II; other site 693746008327 S-adenosylmethionine synthetase; Validated; Region: PRK05250 693746008328 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693746008329 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 693746008330 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 693746008331 Rhomboid family; Region: Rhomboid; cl11446 693746008332 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 693746008333 active site 693746008334 nucleotide binding site [chemical binding]; other site 693746008335 HIGH motif; other site 693746008336 KMSKS motif; other site 693746008337 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 693746008338 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 693746008339 NAD(P) binding site [chemical binding]; other site 693746008340 LDH/MDH dimer interface [polypeptide binding]; other site 693746008341 substrate binding site [chemical binding]; other site 693746008342 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 693746008343 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746008344 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 693746008345 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 693746008346 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 693746008347 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 693746008348 hypothetical protein; Provisional; Region: PRK13670 693746008349 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 693746008350 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 693746008351 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 693746008352 dinuclear metal binding motif [ion binding]; other site 693746008353 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 693746008354 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 693746008355 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746008356 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746008357 DNA binding residues [nucleotide binding] 693746008358 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746008359 Penicillinase repressor; Region: Penicillinase_R; pfam03965 693746008360 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746008361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746008362 Transposase; Region: HTH_Tnp_1; cl17663 693746008363 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746008364 Integrase core domain; Region: rve; pfam00665 693746008365 Integrase core domain; Region: rve_3; cl15866 693746008366 Protein of unknown function DUF86; Region: DUF86; cl01031 693746008367 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 693746008368 active site 693746008369 NTP binding site [chemical binding]; other site 693746008370 metal binding triad [ion binding]; metal-binding site 693746008371 antibiotic binding site [chemical binding]; other site 693746008372 Restriction endonuclease [Defense mechanisms]; Region: COG3587 693746008373 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746008374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746008375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 693746008376 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 693746008377 Double zinc ribbon; Region: DZR; pfam12773 693746008378 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 693746008379 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 693746008380 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 693746008381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693746008382 metal ion-dependent adhesion site (MIDAS); other site 693746008383 Double zinc ribbon; Region: DZR; pfam12773 693746008384 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 693746008385 Catalytic domain of Protein Kinases; Region: PKc; cd00180 693746008386 active site 693746008387 ATP binding site [chemical binding]; other site 693746008388 substrate binding site [chemical binding]; other site 693746008389 activation loop (A-loop); other site 693746008390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693746008391 binding surface 693746008392 TPR motif; other site 693746008393 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693746008394 TPR motif; other site 693746008395 binding surface 693746008396 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 693746008397 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 693746008398 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 693746008399 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 693746008400 Proteins of 100 residues with WXG; Region: WXG100; cl02005 693746008401 phosphodiesterase; Provisional; Region: PRK12704 693746008402 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 693746008403 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 693746008404 LytTr DNA-binding domain; Region: LytTR; smart00850 693746008405 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 693746008406 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 693746008407 phosphopeptide binding site; other site 693746008408 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 693746008409 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693746008410 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 693746008411 S-layer homology domain; Region: SLH; pfam00395 693746008412 S-layer homology domain; Region: SLH; pfam00395 693746008413 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 693746008414 phosphopeptide binding site; other site 693746008415 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 693746008416 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 693746008417 Double zinc ribbon; Region: DZR; pfam12773 693746008418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746008419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746008420 Walker A/P-loop; other site 693746008421 ATP binding site [chemical binding]; other site 693746008422 Q-loop/lid; other site 693746008423 ABC transporter signature motif; other site 693746008424 Walker B; other site 693746008425 D-loop; other site 693746008426 H-loop/switch region; other site 693746008427 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 693746008428 Double zinc ribbon; Region: DZR; pfam12773 693746008429 Transposase; Region: HTH_Tnp_1; cl17663 693746008430 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746008431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746008432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746008433 DNA binding residues [nucleotide binding] 693746008434 Integrase core domain; Region: rve; pfam00665 693746008435 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693746008436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746008437 Walker A motif; other site 693746008438 ATP binding site [chemical binding]; other site 693746008439 Walker B motif; other site 693746008440 arginine finger; other site 693746008441 Integrase core domain; Region: rve; pfam00665 693746008442 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008443 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 693746008444 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 693746008445 BNR repeat-like domain; Region: BNR_2; pfam13088 693746008446 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 693746008447 L-aspartate oxidase; Provisional; Region: PRK06175 693746008448 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 693746008449 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 693746008450 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693746008451 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 693746008452 classical (c) SDRs; Region: SDR_c; cd05233 693746008453 NAD(P) binding site [chemical binding]; other site 693746008454 active site 693746008455 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 693746008456 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 693746008457 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 693746008458 inhibitor site; inhibition site 693746008459 active site 693746008460 dimer interface [polypeptide binding]; other site 693746008461 catalytic residue [active] 693746008462 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 693746008463 putative active site [active] 693746008464 metal binding site [ion binding]; metal-binding site 693746008465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 693746008466 Propionate catabolism activator; Region: PrpR_N; pfam06506 693746008467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693746008468 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 693746008469 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 693746008470 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 693746008471 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 693746008472 Zn binding site [ion binding]; other site 693746008473 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 693746008474 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 693746008475 active site 693746008476 Protein of unknown function DUF86; Region: DUF86; cl01031 693746008477 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 693746008478 active site 693746008479 NTP binding site [chemical binding]; other site 693746008480 metal binding triad [ion binding]; metal-binding site 693746008481 antibiotic binding site [chemical binding]; other site 693746008482 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746008483 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 693746008484 catalytic residues [active] 693746008485 catalytic nucleophile [active] 693746008486 Presynaptic Site I dimer interface [polypeptide binding]; other site 693746008487 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 693746008488 Synaptic Flat tetramer interface [polypeptide binding]; other site 693746008489 Synaptic Site I dimer interface [polypeptide binding]; other site 693746008490 DNA binding site [nucleotide binding] 693746008491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746008492 non-specific DNA binding site [nucleotide binding]; other site 693746008493 salt bridge; other site 693746008494 sequence-specific DNA binding site [nucleotide binding]; other site 693746008495 Predicted transcriptional regulator [Transcription]; Region: COG2378 693746008496 WYL domain; Region: WYL; pfam13280 693746008497 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746008498 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746008499 Integrase core domain; Region: rve; pfam00665 693746008500 tellurium resistance terB-like protein; Region: terB_like; cl11965 693746008501 metal binding site [ion binding]; metal-binding site 693746008502 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 693746008503 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 693746008504 active site 693746008505 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 693746008506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746008507 ATP binding site [chemical binding]; other site 693746008508 putative Mg++ binding site [ion binding]; other site 693746008509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746008510 nucleotide binding region [chemical binding]; other site 693746008511 ATP-binding site [chemical binding]; other site 693746008512 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746008513 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746008514 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746008515 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746008516 Int/Topo IB signature motif; other site 693746008517 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 693746008518 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 693746008519 dimerization interface [polypeptide binding]; other site 693746008520 domain crossover interface; other site 693746008521 redox-dependent activation switch; other site 693746008522 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693746008523 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746008524 S-adenosylmethionine binding site [chemical binding]; other site 693746008525 Trp repressor protein; Region: Trp_repressor; cl17266 693746008526 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 693746008527 AAA domain; Region: AAA_18; pfam13238 693746008528 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693746008529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746008530 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 693746008531 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746008532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746008533 putative active site [active] 693746008534 heme pocket [chemical binding]; other site 693746008535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746008536 putative active site [active] 693746008537 heme pocket [chemical binding]; other site 693746008538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 693746008539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746008540 dimer interface [polypeptide binding]; other site 693746008541 phosphorylation site [posttranslational modification] 693746008542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746008543 ATP binding site [chemical binding]; other site 693746008544 Mg2+ binding site [ion binding]; other site 693746008545 G-X-G motif; other site 693746008546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746008547 active site 693746008548 phosphorylation site [posttranslational modification] 693746008549 intermolecular recognition site; other site 693746008550 dimerization interface [polypeptide binding]; other site 693746008551 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 693746008552 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 693746008553 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746008554 active site 693746008555 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 693746008556 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 693746008557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693746008558 elongation factor Tu; Reviewed; Region: PRK00049 693746008559 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 693746008560 G1 box; other site 693746008561 GEF interaction site [polypeptide binding]; other site 693746008562 GTP/Mg2+ binding site [chemical binding]; other site 693746008563 Switch I region; other site 693746008564 G2 box; other site 693746008565 G3 box; other site 693746008566 Switch II region; other site 693746008567 G4 box; other site 693746008568 G5 box; other site 693746008569 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 693746008570 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 693746008571 Antibiotic Binding Site [chemical binding]; other site 693746008572 elongation factor G; Reviewed; Region: PRK00007 693746008573 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 693746008574 G1 box; other site 693746008575 putative GEF interaction site [polypeptide binding]; other site 693746008576 GTP/Mg2+ binding site [chemical binding]; other site 693746008577 Switch I region; other site 693746008578 G2 box; other site 693746008579 G3 box; other site 693746008580 Switch II region; other site 693746008581 G4 box; other site 693746008582 G5 box; other site 693746008583 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693746008584 Elongation Factor G, domain II; Region: EFG_II; pfam14492 693746008585 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693746008586 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693746008587 30S ribosomal protein S7; Validated; Region: PRK05302 693746008588 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 693746008589 S17 interaction site [polypeptide binding]; other site 693746008590 S8 interaction site; other site 693746008591 16S rRNA interaction site [nucleotide binding]; other site 693746008592 streptomycin interaction site [chemical binding]; other site 693746008593 23S rRNA interaction site [nucleotide binding]; other site 693746008594 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 693746008595 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 693746008596 Uncharacterized conserved protein (DUF2042); Region: DUF2042; cl10727 693746008597 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746008598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746008599 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746008600 catalytic nucleophile [active] 693746008601 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746008602 Integrase core domain; Region: rve; pfam00665 693746008603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746008604 Transposase; Region: HTH_Tnp_1; cl17663 693746008605 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 693746008606 NlpC/p60-like transpeptidase; Region: Transpep_BrtH; pfam14399 693746008607 putative active site [active] 693746008608 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746008609 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 693746008610 DNA binding residues [nucleotide binding] 693746008611 drug binding residues [chemical binding]; other site 693746008612 dimer interface [polypeptide binding]; other site 693746008613 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693746008614 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 693746008615 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746008616 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008617 active site 693746008618 DNA binding site [nucleotide binding] 693746008619 Int/Topo IB signature motif; other site 693746008620 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746008621 Putative transposase; Region: Y2_Tnp; pfam04986 693746008622 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 693746008623 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008624 active site 693746008625 DNA binding site [nucleotide binding] 693746008626 Int/Topo IB signature motif; other site 693746008627 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 693746008628 Putative transposase; Region: Y2_Tnp; pfam04986 693746008629 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746008630 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746008631 EDD domain protein, DegV family; Region: DegV; TIGR00762 693746008632 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_4; pfam13495 693746008633 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746008636 DNA binding site [nucleotide binding] 693746008637 active site 693746008638 Int/Topo IB signature motif; other site 693746008639 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693746008640 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 693746008641 active site 693746008642 S-layer homology domain; Region: SLH; pfam00395 693746008643 S-layer homology domain; Region: SLH; pfam00395 693746008644 S-layer homology domain; Region: SLH; pfam00395 693746008645 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746008646 Integrase core domain; Region: rve; pfam00665 693746008647 Integrase core domain; Region: rve_3; cl15866 693746008648 HTH-like domain; Region: HTH_21; pfam13276 693746008649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746008650 Transposase; Region: HTH_Tnp_1; cl17663 693746008651 Transposase domain (DUF772); Region: DUF772; pfam05598 693746008652 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746008653 aspartate aminotransferase; Provisional; Region: PRK05764 693746008654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746008655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746008656 homodimer interface [polypeptide binding]; other site 693746008657 catalytic residue [active] 693746008658 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746008659 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 693746008660 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693746008661 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693746008662 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693746008663 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746008664 dimer interface [polypeptide binding]; other site 693746008665 PYR/PP interface [polypeptide binding]; other site 693746008666 TPP binding site [chemical binding]; other site 693746008667 substrate binding site [chemical binding]; other site 693746008668 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693746008669 Domain of unknown function; Region: EKR; pfam10371 693746008670 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693746008671 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 693746008672 TPP-binding site [chemical binding]; other site 693746008673 dimer interface [polypeptide binding]; other site 693746008674 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 693746008675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746008676 DNA-binding site [nucleotide binding]; DNA binding site 693746008677 FCD domain; Region: FCD; pfam07729 693746008678 potential frameshift: common BLAST hit: gi|89895586|ref|YP_519073.1| transposase 693746008679 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746008680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746008681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746008682 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746008683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693746008684 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693746008685 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 693746008686 GTP/Mg2+ binding site [chemical binding]; other site 693746008687 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 693746008688 G5 box; other site 693746008689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746008690 G1 box; other site 693746008691 Walker A motif; other site 693746008692 ATP binding site [chemical binding]; other site 693746008693 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 693746008694 active site 693746008695 catalytic residue [active] 693746008696 dimer interface [polypeptide binding]; other site 693746008697 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 693746008698 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693746008699 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693746008700 shikimate binding site; other site 693746008701 NAD(P) binding site [chemical binding]; other site 693746008702 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 693746008703 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693746008704 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 693746008705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746008706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746008707 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746008708 dimerization interface [polypeptide binding]; other site 693746008709 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 693746008710 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 693746008711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 693746008712 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746008713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746008714 Walker A motif; other site 693746008715 ATP binding site [chemical binding]; other site 693746008716 Walker B motif; other site 693746008717 arginine finger; other site 693746008718 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 693746008719 putative catalytic cysteine [active] 693746008720 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 693746008721 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 693746008722 PYR/PP interface [polypeptide binding]; other site 693746008723 dimer interface [polypeptide binding]; other site 693746008724 TPP binding site [chemical binding]; other site 693746008725 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 693746008726 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 693746008727 TPP-binding site [chemical binding]; other site 693746008728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746008729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746008730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746008731 dimerization interface [polypeptide binding]; other site 693746008732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746008733 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746008734 Walker A motif; other site 693746008735 ATP binding site [chemical binding]; other site 693746008736 Walker B motif; other site 693746008737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746008738 Integrase core domain; Region: rve; pfam00665 693746008739 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 693746008740 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 693746008741 ring oligomerisation interface [polypeptide binding]; other site 693746008742 ATP/Mg binding site [chemical binding]; other site 693746008743 stacking interactions; other site 693746008744 hinge regions; other site 693746008745 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 693746008746 oligomerisation interface [polypeptide binding]; other site 693746008747 mobile loop; other site 693746008748 roof hairpin; other site 693746008749 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 693746008750 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 693746008751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746008752 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 693746008753 prohibitin homologues; Region: PHB; smart00244 693746008754 Paraslipin or slipin-2 (SLP-2, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_paraslipin; cd08829 693746008755 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 693746008756 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 693746008757 XdhC Rossmann domain; Region: XdhC_C; pfam13478 693746008758 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 693746008759 catalytic motif [active] 693746008760 Zn binding site [ion binding]; other site 693746008761 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 693746008762 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693746008763 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746008764 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 693746008765 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 693746008766 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 693746008767 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 693746008768 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 693746008769 Uncharacterized conserved protein [Function unknown]; Region: COG1683 693746008770 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 693746008771 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 693746008772 putative active site [active] 693746008773 nucleotide binding site [chemical binding]; other site 693746008774 nudix motif; other site 693746008775 putative metal binding site [ion binding]; other site 693746008776 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693746008777 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 693746008778 rod shape-determining protein Mbl; Provisional; Region: PRK13928 693746008779 MreB and similar proteins; Region: MreB_like; cd10225 693746008780 nucleotide binding site [chemical binding]; other site 693746008781 Mg binding site [ion binding]; other site 693746008782 putative protofilament interaction site [polypeptide binding]; other site 693746008783 RodZ interaction site [polypeptide binding]; other site 693746008784 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 693746008785 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746008786 active site 693746008787 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746008788 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746008789 non-specific DNA binding site [nucleotide binding]; other site 693746008790 salt bridge; other site 693746008791 sequence-specific DNA binding site [nucleotide binding]; other site 693746008792 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 693746008793 Nucleoside recognition; Region: Gate; pfam07670 693746008794 YabP family; Region: YabP; cl06766 693746008795 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 693746008796 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 693746008797 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 693746008798 PhoH-like protein; Region: PhoH; pfam02562 693746008799 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 693746008800 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 693746008801 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693746008802 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 693746008803 AAA domain; Region: AAA_30; pfam13604 693746008804 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 693746008805 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693746008806 TM-ABC transporter signature motif; other site 693746008807 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 693746008808 TM-ABC transporter signature motif; other site 693746008809 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 693746008810 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 693746008811 Walker A/P-loop; other site 693746008812 ATP binding site [chemical binding]; other site 693746008813 Q-loop/lid; other site 693746008814 ABC transporter signature motif; other site 693746008815 Walker B; other site 693746008816 D-loop; other site 693746008817 H-loop/switch region; other site 693746008818 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 693746008819 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693746008820 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 693746008821 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693746008822 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 693746008823 intersubunit interface [polypeptide binding]; other site 693746008824 active site 693746008825 catalytic residue [active] 693746008826 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 693746008827 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746008828 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 693746008829 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693746008830 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 693746008831 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693746008832 DEAD-like helicases superfamily; Region: DEXDc; smart00487 693746008833 ATP binding site [chemical binding]; other site 693746008834 Mg++ binding site [ion binding]; other site 693746008835 motif III; other site 693746008836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746008837 nucleotide binding region [chemical binding]; other site 693746008838 ATP-binding site [chemical binding]; other site 693746008839 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 693746008840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746008841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746008842 non-specific DNA binding site [nucleotide binding]; other site 693746008843 salt bridge; other site 693746008844 sequence-specific DNA binding site [nucleotide binding]; other site 693746008845 Transposase domain (DUF772); Region: DUF772; pfam05598 693746008846 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746008847 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746008848 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 693746008849 homodimer interface [polypeptide binding]; other site 693746008850 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 693746008851 active site pocket [active] 693746008852 glycogen synthase; Provisional; Region: glgA; PRK00654 693746008853 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 693746008854 ADP-binding pocket [chemical binding]; other site 693746008855 homodimer interface [polypeptide binding]; other site 693746008856 Histone H1-like nucleoprotein HC2; Region: HC2; cl19298 693746008857 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 693746008858 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693746008859 ligand binding site; other site 693746008860 oligomer interface; other site 693746008861 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693746008862 putative trimer interface [polypeptide binding]; other site 693746008863 putative CoA binding site [chemical binding]; other site 693746008864 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 693746008865 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 693746008866 ligand binding site; other site 693746008867 oligomer interface; other site 693746008868 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 693746008869 putative trimer interface [polypeptide binding]; other site 693746008870 putative CoA binding site [chemical binding]; other site 693746008871 glycogen branching enzyme; Provisional; Region: PRK12313 693746008872 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 693746008873 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 693746008874 active site 693746008875 catalytic site [active] 693746008876 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 693746008877 transcription factor E; Region: TIGR00373 693746008878 RNAse P Rpr2/Rpp21/SNM1 subunit domain; Region: Rpr2; cl00887 693746008879 heat shock protein 90; Provisional; Region: PRK05218 693746008880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746008881 ATP binding site [chemical binding]; other site 693746008882 Mg2+ binding site [ion binding]; other site 693746008883 G-X-G motif; other site 693746008884 Hsp90 protein; Region: HSP90; pfam00183 693746008885 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 693746008886 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 693746008887 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693746008888 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746008889 FeS/SAM binding site; other site 693746008890 recombination regulator RecX; Reviewed; Region: recX; PRK00117 693746008891 recombinase A; Provisional; Region: recA; PRK09354 693746008892 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 693746008893 hexamer interface [polypeptide binding]; other site 693746008894 Walker A motif; other site 693746008895 ATP binding site [chemical binding]; other site 693746008896 Walker B motif; other site 693746008897 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 693746008898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746008899 S-adenosylmethionine binding site [chemical binding]; other site 693746008900 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 693746008901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746008902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746008903 dimerization interface [polypeptide binding]; other site 693746008904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746008905 dimer interface [polypeptide binding]; other site 693746008906 phosphorylation site [posttranslational modification] 693746008907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746008908 ATP binding site [chemical binding]; other site 693746008909 Mg2+ binding site [ion binding]; other site 693746008910 G-X-G motif; other site 693746008911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746008912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746008913 active site 693746008914 phosphorylation site [posttranslational modification] 693746008915 intermolecular recognition site; other site 693746008916 dimerization interface [polypeptide binding]; other site 693746008917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746008918 DNA binding site [nucleotide binding] 693746008919 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella; Region: VCBS; pfam13517 693746008920 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 693746008921 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693746008922 ATP binding site [chemical binding]; other site 693746008923 Mg++ binding site [ion binding]; other site 693746008924 motif III; other site 693746008925 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746008926 nucleotide binding region [chemical binding]; other site 693746008927 ATP-binding site [chemical binding]; other site 693746008928 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746008929 Integrase core domain; Region: rve; pfam00665 693746008930 Integrase core domain; Region: rve_3; cl15866 693746008931 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693746008932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746008933 Transposase; Region: HTH_Tnp_1; cl17663 693746008934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 693746008935 DNA-binding site [nucleotide binding]; DNA binding site 693746008936 RNA-binding motif; other site 693746008937 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 693746008938 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746008939 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746008940 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746008941 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 693746008942 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 693746008943 ATP binding site [chemical binding]; other site 693746008944 Mg++ binding site [ion binding]; other site 693746008945 motif III; other site 693746008946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746008947 nucleotide binding region [chemical binding]; other site 693746008948 ATP-binding site [chemical binding]; other site 693746008949 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 693746008950 RNA binding site [nucleotide binding]; other site 693746008951 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746008952 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746008953 catalytic residues [active] 693746008954 catalytic nucleophile [active] 693746008955 Recombinase; Region: Recombinase; pfam07508 693746008956 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746008957 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746008958 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 693746008959 DNA binding residues [nucleotide binding] 693746008960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746008961 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 693746008962 Walker A/P-loop; other site 693746008963 ATP binding site [chemical binding]; other site 693746008964 Q-loop/lid; other site 693746008965 ABC transporter signature motif; other site 693746008966 Walker B; other site 693746008967 D-loop; other site 693746008968 H-loop/switch region; other site 693746008969 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746008970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746008971 Integrase core domain; Region: rve; pfam00665 693746008972 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746008973 transposase/IS protein; Provisional; Region: PRK09183 693746008974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746008975 Walker A motif; other site 693746008976 ATP binding site [chemical binding]; other site 693746008977 Walker B motif; other site 693746008978 potential frameshift: common BLAST hit: gi|317132854|ref|YP_004092168.1| Relaxase/mobilization nuclease family protein 693746008979 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746008980 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746008981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746008982 Walker A/P-loop; other site 693746008983 ATP binding site [chemical binding]; other site 693746008984 Q-loop/lid; other site 693746008985 ABC transporter signature motif; other site 693746008986 Walker B; other site 693746008987 D-loop; other site 693746008988 H-loop/switch region; other site 693746008989 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693746008990 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693746008991 ABC-2 type transporter; Region: ABC2_membrane; cl17235 693746008992 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 693746008993 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 693746008994 AAA ATPase domain; Region: AAA_16; pfam13191 693746008995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 693746008996 TPR motif; other site 693746008997 binding surface 693746008998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693746008999 DNA binding residues [nucleotide binding] 693746009000 dimerization interface [polypeptide binding]; other site 693746009001 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 693746009002 Condensation domain; Region: Condensation; cl19241 693746009003 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746009004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746009005 S-adenosylmethionine binding site [chemical binding]; other site 693746009006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 693746009007 Predicted transcriptional regulators [Transcription]; Region: COG1695 693746009008 putative DNA binding site [nucleotide binding]; other site 693746009009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009011 active site 693746009012 phosphorylation site [posttranslational modification] 693746009013 intermolecular recognition site; other site 693746009014 dimerization interface [polypeptide binding]; other site 693746009015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746009016 dimer interface [polypeptide binding]; other site 693746009017 phosphorylation site [posttranslational modification] 693746009018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746009019 ATP binding site [chemical binding]; other site 693746009020 Mg2+ binding site [ion binding]; other site 693746009021 G-X-G motif; other site 693746009022 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746009023 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746009024 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746009025 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746009026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746009027 putative DNA binding site [nucleotide binding]; other site 693746009028 putative Zn2+ binding site [ion binding]; other site 693746009029 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746009030 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746009031 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 693746009032 AAA domain; Region: AAA_18; pfam13238 693746009033 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 693746009034 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746009035 FeS/SAM binding site; other site 693746009036 Uncharacterized protein, DegV family COG1307; Region: DegV; cl19360 693746009037 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746009038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746009039 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746009040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746009041 Integrase core domain; Region: rve; pfam00665 693746009042 transposase/IS protein; Provisional; Region: PRK09183 693746009043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746009044 Walker A motif; other site 693746009045 ATP binding site [chemical binding]; other site 693746009046 Walker B motif; other site 693746009047 Integrase core domain; Region: rve; pfam00665 693746009048 Integrase core domain; Region: rve; pfam00665 693746009049 Helix-turn-helix domain; Region: HTH_28; pfam13518 693746009050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 693746009051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 693746009052 ligand binding site [chemical binding]; other site 693746009053 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 693746009054 Ferredoxin [Energy production and conversion]; Region: COG1146 693746009055 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746009056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746009057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009058 active site 693746009059 phosphorylation site [posttranslational modification] 693746009060 intermolecular recognition site; other site 693746009061 dimerization interface [polypeptide binding]; other site 693746009062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746009063 DNA binding site [nucleotide binding] 693746009064 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 693746009065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746009066 dimer interface [polypeptide binding]; other site 693746009067 phosphorylation site [posttranslational modification] 693746009068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746009069 ATP binding site [chemical binding]; other site 693746009070 Mg2+ binding site [ion binding]; other site 693746009071 G-X-G motif; other site 693746009072 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 693746009073 TrkA-N domain; Region: TrkA_N; pfam02254 693746009074 TrkA-C domain; Region: TrkA_C; pfam02080 693746009075 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 693746009076 Cation transport protein; Region: TrkH; cl17365 693746009077 TrkA-N domain; Region: TrkA_N; pfam02254 693746009078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 693746009079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746009080 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 693746009081 MMPL family; Region: MMPL; cl14618 693746009082 MMPL family; Region: MMPL; cl14618 693746009083 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 693746009084 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 693746009085 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 693746009086 HlyD family secretion protein; Region: HlyD_3; pfam13437 693746009087 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 693746009088 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 693746009089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746009090 Walker A motif; other site 693746009091 ATP binding site [chemical binding]; other site 693746009092 Walker B motif; other site 693746009093 arginine finger; other site 693746009094 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 693746009095 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 693746009096 metal ion-dependent adhesion site (MIDAS); other site 693746009097 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 693746009098 Predicted transcriptional regulators [Transcription]; Region: COG1725 693746009099 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746009100 DNA-binding site [nucleotide binding]; DNA binding site 693746009101 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746009102 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746009103 Walker A/P-loop; other site 693746009104 ATP binding site [chemical binding]; other site 693746009105 Q-loop/lid; other site 693746009106 ABC transporter signature motif; other site 693746009107 Walker B; other site 693746009108 D-loop; other site 693746009109 H-loop/switch region; other site 693746009110 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 693746009111 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 693746009112 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 693746009113 Walker A/P-loop; other site 693746009114 ATP binding site [chemical binding]; other site 693746009115 Q-loop/lid; other site 693746009116 ABC transporter signature motif; other site 693746009117 Walker B; other site 693746009118 D-loop; other site 693746009119 H-loop/switch region; other site 693746009120 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 693746009121 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 693746009122 Walker A/P-loop; other site 693746009123 ATP binding site [chemical binding]; other site 693746009124 Q-loop/lid; other site 693746009125 ABC transporter signature motif; other site 693746009126 Walker B; other site 693746009127 D-loop; other site 693746009128 H-loop/switch region; other site 693746009129 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 693746009130 TM-ABC transporter signature motif; other site 693746009131 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 693746009132 TM-ABC transporter signature motif; other site 693746009133 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 693746009134 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 693746009135 FtsH Extracellular; Region: FtsH_ext; pfam06480 693746009136 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 693746009137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746009138 Walker A motif; other site 693746009139 ATP binding site [chemical binding]; other site 693746009140 Walker B motif; other site 693746009141 arginine finger; other site 693746009142 Peptidase family M41; Region: Peptidase_M41; pfam01434 693746009143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 693746009144 active site 693746009145 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 693746009146 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 693746009147 Ligand Binding Site [chemical binding]; other site 693746009148 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 693746009149 replicative DNA helicase; Region: DnaB; TIGR00665 693746009150 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 693746009151 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 693746009152 Walker A motif; other site 693746009153 ATP binding site [chemical binding]; other site 693746009154 Walker B motif; other site 693746009155 DNA binding loops [nucleotide binding] 693746009156 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 693746009157 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 693746009158 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 693746009159 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 693746009160 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693746009161 DHH family; Region: DHH; pfam01368 693746009162 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 693746009163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 693746009164 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 693746009165 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693746009166 stage V sporulation protein T; Region: spore_V_T; TIGR02851 693746009167 GAF domain; Region: GAF_3; pfam13492 693746009168 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 693746009169 Cupin domain; Region: Cupin_2; pfam07883 693746009170 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693746009171 putative binding surface; other site 693746009172 active site 693746009173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746009174 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 693746009175 Walker A motif; other site 693746009176 ATP binding site [chemical binding]; other site 693746009177 Walker B motif; other site 693746009178 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 693746009179 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 693746009180 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 693746009181 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 693746009182 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746009183 DNA binding residues [nucleotide binding] 693746009184 dimer interface [polypeptide binding]; other site 693746009185 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 693746009186 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 693746009187 minor groove reading motif; other site 693746009188 helix-hairpin-helix signature motif; other site 693746009189 substrate binding pocket [chemical binding]; other site 693746009190 active site 693746009191 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 693746009192 DNA binding and oxoG recognition site [nucleotide binding] 693746009193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746009194 Coenzyme A binding pocket [chemical binding]; other site 693746009195 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 693746009196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746009197 Coenzyme A binding pocket [chemical binding]; other site 693746009198 thymidine kinase; Provisional; Region: PRK04296 693746009199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746009200 FeS/SAM binding site; other site 693746009201 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746009202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746009203 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 693746009204 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746009205 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 693746009206 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; cl19124 693746009207 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746009208 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746009209 EamA-like transporter family; Region: EamA; pfam00892 693746009210 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 693746009211 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 693746009212 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 693746009213 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693746009214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746009215 DNA-binding site [nucleotide binding]; DNA binding site 693746009216 FCD domain; Region: FCD; pfam07729 693746009217 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 693746009218 homotrimer interaction site [polypeptide binding]; other site 693746009219 putative active site [active] 693746009220 fumarate hydratase; Reviewed; Region: fumC; PRK00485 693746009221 Class II fumarases; Region: Fumarase_classII; cd01362 693746009222 active site 693746009223 tetramer interface [polypeptide binding]; other site 693746009224 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 693746009225 TPP-binding site [chemical binding]; other site 693746009226 dimer interface [polypeptide binding]; other site 693746009227 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 693746009228 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 693746009229 PYR/PP interface [polypeptide binding]; other site 693746009230 dimer interface [polypeptide binding]; other site 693746009231 TPP binding site [chemical binding]; other site 693746009232 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 693746009233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 693746009234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 693746009235 DNA binding site [nucleotide binding] 693746009236 domain linker motif; other site 693746009237 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 693746009238 dimerization interface [polypeptide binding]; other site 693746009239 ligand binding site [chemical binding]; other site 693746009240 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 693746009241 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 693746009242 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 693746009243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746009244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746009245 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 693746009246 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 693746009247 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 693746009248 dimer interface [polypeptide binding]; other site 693746009249 active site 693746009250 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693746009251 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 693746009252 NAD(P) binding site [chemical binding]; other site 693746009253 homotetramer interface [polypeptide binding]; other site 693746009254 homodimer interface [polypeptide binding]; other site 693746009255 active site 693746009256 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 693746009257 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 693746009258 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693746009259 FMN binding site [chemical binding]; other site 693746009260 substrate binding site [chemical binding]; other site 693746009261 putative catalytic residue [active] 693746009262 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 693746009263 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 693746009264 dimer interface [polypeptide binding]; other site 693746009265 active site 693746009266 CoA binding pocket [chemical binding]; other site 693746009267 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 693746009268 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 693746009269 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 693746009270 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693746009271 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693746009272 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 693746009273 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 693746009274 carboxyltransferase (CT) interaction site; other site 693746009275 biotinylation site [posttranslational modification]; other site 693746009276 acyl carrier protein; Provisional; Region: acpP; PRK00982 693746009277 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 693746009278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746009279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746009280 homodimer interface [polypeptide binding]; other site 693746009281 catalytic residue [active] 693746009282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746009283 metal binding site [ion binding]; metal-binding site 693746009284 active site 693746009285 I-site; other site 693746009286 EDD domain protein, DegV family; Region: DegV; TIGR00762 693746009287 Glycerate kinase family; Region: Gly_kinase; cl00841 693746009288 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 693746009289 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746009290 Walker A/P-loop; other site 693746009291 ATP binding site [chemical binding]; other site 693746009292 Q-loop/lid; other site 693746009293 ABC transporter signature motif; other site 693746009294 Walker B; other site 693746009295 D-loop; other site 693746009296 H-loop/switch region; other site 693746009297 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 693746009298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746009299 dimer interface [polypeptide binding]; other site 693746009300 conserved gate region; other site 693746009301 putative PBP binding loops; other site 693746009302 ABC-ATPase subunit interface; other site 693746009303 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 693746009304 NMT1-like family; Region: NMT1_2; cl17432 693746009305 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 693746009306 4-alpha-glucanotransferase; Provisional; Region: PRK14508 693746009307 ornithine carbamoyltransferase; Validated; Region: PRK02102 693746009308 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693746009309 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693746009310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 693746009311 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 693746009312 inhibitor-cofactor binding pocket; inhibition site 693746009313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746009314 catalytic residue [active] 693746009315 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 693746009316 feedback inhibition sensing region; other site 693746009317 homohexameric interface [polypeptide binding]; other site 693746009318 nucleotide binding site [chemical binding]; other site 693746009319 N-acetyl-L-glutamate binding site [chemical binding]; other site 693746009320 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 693746009321 heterotetramer interface [polypeptide binding]; other site 693746009322 active site pocket [active] 693746009323 cleavage site 693746009324 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 693746009325 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 693746009326 argininosuccinate lyase; Provisional; Region: PRK00855 693746009327 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 693746009328 active sites [active] 693746009329 tetramer interface [polypeptide binding]; other site 693746009330 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 693746009331 ANP binding site [chemical binding]; other site 693746009332 Substrate Binding Site II [chemical binding]; other site 693746009333 Substrate Binding Site I [chemical binding]; other site 693746009334 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 693746009335 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 693746009336 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 693746009337 FMN binding site [chemical binding]; other site 693746009338 dimer interface [polypeptide binding]; other site 693746009339 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746009340 dimerization interface [polypeptide binding]; other site 693746009341 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746009342 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746009343 dimer interface [polypeptide binding]; other site 693746009344 putative CheW interface [polypeptide binding]; other site 693746009345 Minimal MMP-like domain found in Thermus thermophilus hypothetical protein TTHA0227 and similar proteins; Region: MMP_TTHA0227; cd12953 693746009346 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 693746009347 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 693746009348 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 693746009349 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 693746009350 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 693746009351 RNA binding site [nucleotide binding]; other site 693746009352 hypothetical protein; Provisional; Region: PRK13663 693746009353 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 693746009354 GDP-binding site [chemical binding]; other site 693746009355 ACT binding site; other site 693746009356 IMP binding site; other site 693746009357 LysE type translocator; Region: LysE; cl00565 693746009358 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 693746009359 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 693746009360 tetramer interface [polypeptide binding]; other site 693746009361 active site 693746009362 asparagine synthetase B; Provisional; Region: asnB; PRK09431 693746009363 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 693746009364 dimer interface [polypeptide binding]; other site 693746009365 active site 693746009366 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 693746009367 Ligand Binding Site [chemical binding]; other site 693746009368 Molecular Tunnel; other site 693746009369 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 693746009370 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 693746009371 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 693746009372 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 693746009373 LrgA family; Region: LrgA; cl00608 693746009374 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 693746009375 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 693746009376 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 693746009377 prephenate dehydrogenase; Validated; Region: PRK08507 693746009378 Prephenate dehydrogenase; Region: PDH; pfam02153 693746009379 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 693746009380 active site 693746009381 dimer interface [polypeptide binding]; other site 693746009382 metal binding site [ion binding]; metal-binding site 693746009383 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 693746009384 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 693746009385 hinge; other site 693746009386 active site 693746009387 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 693746009388 Tetramer interface [polypeptide binding]; other site 693746009389 active site 693746009390 FMN-binding site [chemical binding]; other site 693746009391 Chorismate mutase [Amino acid transport and metabolism]; Region: PheA; COG1605 693746009392 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 693746009393 Prephenate dehydratase; Region: PDT; pfam00800 693746009394 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 693746009395 putative L-Phe binding site [chemical binding]; other site 693746009396 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 693746009397 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 693746009398 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 693746009399 shikimate binding site; other site 693746009400 NAD(P) binding site [chemical binding]; other site 693746009401 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 693746009402 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 693746009403 ADP binding site [chemical binding]; other site 693746009404 magnesium binding site [ion binding]; other site 693746009405 putative shikimate binding site; other site 693746009406 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 693746009407 trimer interface [polypeptide binding]; other site 693746009408 active site 693746009409 dimer interface [polypeptide binding]; other site 693746009410 Virus attachment protein p12 family; Region: P12; pfam12669 693746009411 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 693746009412 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693746009413 G1 box; other site 693746009414 GTP/Mg2+ binding site [chemical binding]; other site 693746009415 Switch I region; other site 693746009416 G2 box; other site 693746009417 G3 box; other site 693746009418 Switch II region; other site 693746009419 G4 box; other site 693746009420 G5 box; other site 693746009421 Nucleoside recognition; Region: Gate; pfam07670 693746009422 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693746009423 Nucleoside recognition; Region: Gate; pfam07670 693746009424 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 693746009425 FeoA domain; Region: FeoA; pfam04023 693746009426 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746009427 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746009428 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746009429 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 693746009430 Carbon starvation protein CstA; Region: CstA; pfam02554 693746009431 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 693746009432 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693746009433 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746009434 DNA-binding site [nucleotide binding]; DNA binding site 693746009435 FCD domain; Region: FCD; pfam07729 693746009436 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746009437 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 693746009438 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 693746009439 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 693746009440 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746009441 dimer interface [polypeptide binding]; other site 693746009442 PYR/PP interface [polypeptide binding]; other site 693746009443 TPP binding site [chemical binding]; other site 693746009444 substrate binding site [chemical binding]; other site 693746009445 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 693746009446 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 693746009447 TPP-binding site [chemical binding]; other site 693746009448 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 693746009449 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 693746009450 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 693746009451 homodimer interface [polypeptide binding]; other site 693746009452 substrate-cofactor binding pocket; other site 693746009453 catalytic residue [active] 693746009454 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 693746009455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746009456 NAD(P) binding site [chemical binding]; other site 693746009457 active site 693746009458 DctM-like transporters; Region: DctM; pfam06808 693746009459 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746009460 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693746009461 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746009462 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 693746009463 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 693746009464 putative active site [active] 693746009465 catalytic triad [active] 693746009466 putative dimer interface [polypeptide binding]; other site 693746009467 Transcriptional regulators [Transcription]; Region: GntR; COG1802 693746009468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746009469 DNA-binding site [nucleotide binding]; DNA binding site 693746009470 FCD domain; Region: FCD; pfam07729 693746009471 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 693746009472 putative transposase OrfB; Reviewed; Region: PHA02517 693746009473 HTH-like domain; Region: HTH_21; pfam13276 693746009474 Integrase core domain; Region: rve; pfam00665 693746009475 Integrase core domain; Region: rve_3; cl15866 693746009476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009477 Transposase; Region: HTH_Tnp_1; cl17663 693746009478 Transcriptional regulators [Transcription]; Region: MarR; COG1846 693746009479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746009480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746009481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746009482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746009483 Walker A/P-loop; other site 693746009484 ATP binding site [chemical binding]; other site 693746009485 Q-loop/lid; other site 693746009486 ABC transporter signature motif; other site 693746009487 Walker B; other site 693746009488 D-loop; other site 693746009489 H-loop/switch region; other site 693746009490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 693746009491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 693746009492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746009493 Walker A/P-loop; other site 693746009494 ATP binding site [chemical binding]; other site 693746009495 Q-loop/lid; other site 693746009496 ABC transporter signature motif; other site 693746009497 Walker B; other site 693746009498 D-loop; other site 693746009499 H-loop/switch region; other site 693746009500 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693746009501 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 693746009502 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693746009503 active site 693746009504 metal binding site [ion binding]; metal-binding site 693746009505 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746009506 Integrase core domain; Region: rve; pfam00665 693746009507 Integrase core domain; Region: rve_3; cl15866 693746009508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009509 Transposase; Region: HTH_Tnp_1; cl17663 693746009510 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 693746009511 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746009512 transposase/IS protein; Provisional; Region: PRK09183 693746009513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746009514 Walker A motif; other site 693746009515 ATP binding site [chemical binding]; other site 693746009516 Walker B motif; other site 693746009517 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746009518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746009519 Integrase core domain; Region: rve; pfam00665 693746009520 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746009521 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746009522 catalytic residues [active] 693746009523 catalytic nucleophile [active] 693746009524 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 693746009525 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 693746009526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009527 Transposase; Region: HTH_Tnp_1; cl17663 693746009528 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746009529 HTH-like domain; Region: HTH_21; pfam13276 693746009530 Integrase core domain; Region: rve; pfam00665 693746009531 Integrase core domain; Region: rve_3; cl15866 693746009532 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693746009533 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693746009534 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693746009535 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693746009536 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 693746009537 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746009538 Transposase domain (DUF772); Region: DUF772; pfam05598 693746009539 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746009540 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 693746009541 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746009542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009543 Transposase; Region: HTH_Tnp_1; cl17663 693746009544 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746009545 HTH-like domain; Region: HTH_21; pfam13276 693746009546 Integrase core domain; Region: rve; pfam00665 693746009547 Integrase core domain; Region: rve_3; cl15866 693746009548 Transposase domain (DUF772); Region: DUF772; pfam05598 693746009549 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746009550 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 693746009551 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693746009552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746009553 DNA-binding site [nucleotide binding]; DNA binding site 693746009554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746009555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746009556 homodimer interface [polypeptide binding]; other site 693746009557 catalytic residue [active] 693746009558 Domain of unknown function (DUF4428); Region: DUF4428; pfam14471 693746009559 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 693746009560 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 693746009561 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 693746009562 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746009563 catalytic loop [active] 693746009564 iron binding site [ion binding]; other site 693746009565 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693746009566 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 693746009567 FAD binding domain; Region: FAD_binding_4; cl19922 693746009568 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 693746009569 potential frameshift: common BLAST hit: gi|170760001|ref|YP_001788172.1| xanthine dehydrogenase family protein, molybdopterin-binding 693746009570 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746009571 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693746009572 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746009573 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 693746009574 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746009575 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746009576 YIEGIA protein; Region: YIEGIA; pfam14045 693746009577 YIEGIA protein; Region: YIEGIA; pfam14045 693746009578 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 693746009579 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 693746009580 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 693746009581 G1 box; other site 693746009582 GTP/Mg2+ binding site [chemical binding]; other site 693746009583 Switch I region; other site 693746009584 G2 box; other site 693746009585 G3 box; other site 693746009586 Switch II region; other site 693746009587 G4 box; other site 693746009588 G5 box; other site 693746009589 Nucleoside recognition; Region: Gate; pfam07670 693746009590 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 693746009591 Nucleoside recognition; Region: Gate; pfam07670 693746009592 FeoA domain; Region: FeoA; pfam04023 693746009593 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 693746009594 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 693746009595 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 693746009596 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 693746009597 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746009598 Integrase core domain; Region: rve; pfam00665 693746009599 Integrase core domain; Region: rve_3; cl15866 693746009600 HTH-like domain; Region: HTH_21; pfam13276 693746009601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009602 Transposase; Region: HTH_Tnp_1; cl17663 693746009603 Integrase core domain; Region: rve; pfam00665 693746009604 Integrase core domain; Region: rve_3; cl15866 693746009605 Integrase core domain; Region: rve_3; cl15866 693746009606 Integrase core domain; Region: rve; pfam00665 693746009607 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746009608 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 693746009609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 693746009610 Histidine kinase; Region: HisKA_3; pfam07730 693746009611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746009612 ATP binding site [chemical binding]; other site 693746009613 Mg2+ binding site [ion binding]; other site 693746009614 G-X-G motif; other site 693746009615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693746009616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009617 active site 693746009618 phosphorylation site [posttranslational modification] 693746009619 intermolecular recognition site; other site 693746009620 dimerization interface [polypeptide binding]; other site 693746009621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 693746009622 DNA binding residues [nucleotide binding] 693746009623 dimerization interface [polypeptide binding]; other site 693746009624 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 693746009625 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 693746009626 phosphate binding site [ion binding]; other site 693746009627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746009628 Walker A/P-loop; other site 693746009629 ATP binding site [chemical binding]; other site 693746009630 Q-loop/lid; other site 693746009631 ABC transporter signature motif; other site 693746009632 Walker B; other site 693746009633 D-loop; other site 693746009634 H-loop/switch region; other site 693746009635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 693746009636 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 693746009637 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 693746009638 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746009639 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 693746009640 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 693746009641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746009642 catalytic residue [active] 693746009643 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 693746009644 tetramer interface [polypeptide binding]; other site 693746009645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746009646 catalytic residue [active] 693746009647 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 693746009648 lipoyl attachment site [posttranslational modification]; other site 693746009649 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 693746009650 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 693746009651 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 693746009652 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 693746009653 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746009654 catalytic residue [active] 693746009655 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746009656 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 693746009657 glutaminase A; Region: Gln_ase; TIGR03814 693746009658 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746009659 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746009660 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 693746009661 dimerization interface [polypeptide binding]; other site 693746009662 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 693746009663 potential frameshift: common BLAST hit: gi|347531492|ref|YP_004838255.1| L-ribulokinase 693746009664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746009665 nucleotide binding site [chemical binding]; other site 693746009666 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 693746009667 nucleotide binding site [chemical binding]; other site 693746009668 Domain of unknown function (DUF386); Region: DUF386; cl01047 693746009669 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 693746009670 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746009671 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693746009672 DctM-like transporters; Region: DctM; pfam06808 693746009673 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746009674 Transcriptional regulators [Transcription]; Region: FadR; COG2186 693746009675 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746009676 DNA-binding site [nucleotide binding]; DNA binding site 693746009677 FCD domain; Region: FCD; pfam07729 693746009678 imidazole glycerol phosphate synthase hisHF; Region: PLN02617 693746009679 potential frameshift: common BLAST hit: gi|89895586|ref|YP_519073.1| transposase 693746009680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746009681 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746009682 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746009683 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746009684 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746009685 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746009686 Integrase core domain; Region: rve; pfam00665 693746009687 Integrase core domain; Region: rve_3; cl15866 693746009688 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 693746009689 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009690 Transposase; Region: HTH_Tnp_1; cl17663 693746009691 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746009692 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746009693 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746009694 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746009695 putative active site [active] 693746009696 heme pocket [chemical binding]; other site 693746009697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746009698 putative active site [active] 693746009699 heme pocket [chemical binding]; other site 693746009700 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746009701 metal binding site [ion binding]; metal-binding site 693746009702 active site 693746009703 I-site; other site 693746009704 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 693746009705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 693746009706 Zn2+ binding site [ion binding]; other site 693746009707 Mg2+ binding site [ion binding]; other site 693746009708 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 693746009709 HAMP domain; Region: HAMP; pfam00672 693746009710 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746009711 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 693746009712 dimer interface [polypeptide binding]; other site 693746009713 putative CheW interface [polypeptide binding]; other site 693746009714 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693746009715 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 693746009716 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 693746009717 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746009718 Int/Topo IB signature motif; other site 693746009719 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 693746009720 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 693746009721 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 693746009722 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 693746009723 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 693746009724 active site 693746009725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746009726 S-adenosylmethionine binding site [chemical binding]; other site 693746009727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 693746009728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 693746009729 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 693746009730 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 693746009731 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 693746009732 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 693746009733 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 693746009734 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 693746009735 Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659 693746009736 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746009737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746009738 potential frameshift: common BLAST hit: gi|302340126|ref|YP_003805332.1| Integrase catalytic subunit 693746009739 Integrase core domain; Region: rve; pfam00665 693746009740 Integrase core domain; Region: rve_3; cl15866 693746009741 HTH-like domain; Region: HTH_21; pfam13276 693746009742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009743 Transposase; Region: HTH_Tnp_1; cl17663 693746009744 potential frameshift: common BLAST hit: gi|347533384|ref|YP_004840147.1| transposase mutator type 693746009745 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746009746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746009747 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746009748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 693746009749 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 693746009750 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 693746009751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 693746009752 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 693746009753 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746009754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009755 active site 693746009756 phosphorylation site [posttranslational modification] 693746009757 intermolecular recognition site; other site 693746009758 dimerization interface [polypeptide binding]; other site 693746009759 CheD chemotactic sensory transduction; Region: CheD; cl00810 693746009760 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 693746009761 CheC-like family; Region: CheC; pfam04509 693746009762 Chemotaxis phosphatase CheX; Region: CheX; cl15816 693746009763 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 693746009764 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693746009765 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693746009766 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 693746009767 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693746009768 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 693746009769 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 693746009770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 693746009771 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 693746009772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 693746009773 DNA binding residues [nucleotide binding] 693746009774 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 693746009775 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 693746009776 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 693746009777 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 693746009778 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 693746009779 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 693746009780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009781 active site 693746009782 phosphorylation site [posttranslational modification] 693746009783 intermolecular recognition site; other site 693746009784 dimerization interface [polypeptide binding]; other site 693746009785 flagellar motor switch protein; Reviewed; Region: PRK06782 693746009786 CheC-like family; Region: CheC; pfam04509 693746009787 CheC-like family; Region: CheC; pfam04509 693746009788 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 693746009789 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 693746009790 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 693746009791 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 693746009792 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 693746009793 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 693746009794 ligand binding site [chemical binding]; other site 693746009795 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 693746009796 Flagellar protein (FlbD); Region: FlbD; pfam06289 693746009797 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 693746009798 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693746009799 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693746009800 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 693746009801 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 693746009802 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 693746009803 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 693746009804 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 693746009805 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 693746009806 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 693746009807 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 693746009808 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 693746009809 Walker A motif/ATP binding site; other site 693746009810 Walker B motif; other site 693746009811 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 693746009812 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 693746009813 Flagellar assembly protein FliH; Region: FliH; cl19405 693746009814 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 693746009815 FliG N-terminal domain; Region: FliG_N; pfam14842 693746009816 FliG middle domain; Region: FliG_M; pfam14841 693746009817 FliG C-terminal domain; Region: FliG_C; pfam01706 693746009818 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 693746009819 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 693746009820 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 693746009821 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 693746009822 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 693746009823 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693746009824 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693746009825 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 693746009826 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 693746009827 Global regulator protein family; Region: CsrA; pfam02599 693746009828 FliW protein; Region: FliW; cl00740 693746009829 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 693746009830 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 693746009831 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 693746009832 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 693746009833 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 693746009834 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 693746009835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009836 active site 693746009837 phosphorylation site [posttranslational modification] 693746009838 intermolecular recognition site; other site 693746009839 dimerization interface [polypeptide binding]; other site 693746009840 CheB methylesterase; Region: CheB_methylest; pfam01339 693746009841 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 693746009842 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 693746009843 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 693746009844 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 693746009845 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 693746009846 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 693746009847 putative binding surface; other site 693746009848 active site 693746009849 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 693746009850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746009851 ATP binding site [chemical binding]; other site 693746009852 Mg2+ binding site [ion binding]; other site 693746009853 G-X-G motif; other site 693746009854 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 693746009855 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 693746009856 PilZ domain; Region: PilZ; pfam07238 693746009857 S-layer homology domain; Region: SLH; pfam00395 693746009858 S-layer homology domain; Region: SLH; pfam00395 693746009859 S-layer homology domain; Region: SLH; pfam00395 693746009860 S-layer homology domain; Region: SLH; pfam00395 693746009861 S-layer homology domain; Region: SLH; pfam00395 693746009862 S-layer homology domain; Region: SLH; pfam00395 693746009863 PilZ domain; Region: PilZ; pfam07238 693746009864 PilZ domain; Region: PilZ; pfam07238 693746009865 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 693746009866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746009867 S-adenosylmethionine binding site [chemical binding]; other site 693746009868 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746009869 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746009870 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 693746009871 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 693746009872 catalytic residue [active] 693746009873 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 693746009874 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693746009875 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746009876 FeS/SAM binding site; other site 693746009877 5'-nucleotidase; Provisional; Region: PRK03826 693746009878 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 693746009879 Domain of unknown function (DUF362); Region: DUF362; cl19822 693746009880 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746009881 glutamate racemase; Provisional; Region: PRK00865 693746009882 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 693746009883 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 693746009884 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 693746009885 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 693746009886 active site 693746009887 HIGH motif; other site 693746009888 KMSK motif region; other site 693746009889 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 693746009890 tRNA binding surface [nucleotide binding]; other site 693746009891 anticodon binding site; other site 693746009892 AzlC protein; Region: AzlC; cl00570 693746009893 Predicted branched-chain amino acid permeases (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlD; COG1687 693746009894 S-layer homology domain; Region: SLH; pfam00395 693746009895 S-layer homology domain; Region: SLH; pfam00395 693746009896 S-layer homology domain; Region: SLH; pfam00395 693746009897 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 693746009898 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 693746009899 G1 box; other site 693746009900 putative GEF interaction site [polypeptide binding]; other site 693746009901 GTP/Mg2+ binding site [chemical binding]; other site 693746009902 Switch I region; other site 693746009903 G2 box; other site 693746009904 G3 box; other site 693746009905 Switch II region; other site 693746009906 G4 box; other site 693746009907 G5 box; other site 693746009908 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 693746009909 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 693746009910 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 693746009911 putative ligand binding site [chemical binding]; other site 693746009912 putative NAD binding site [chemical binding]; other site 693746009913 putative catalytic site [active] 693746009914 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 693746009915 L-serine binding site [chemical binding]; other site 693746009916 ACT domain interface; other site 693746009917 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746009918 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746009919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746009920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 693746009921 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 693746009922 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746009923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746009924 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 693746009925 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 693746009926 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 693746009927 threonine dehydratase; Provisional; Region: PRK08198 693746009928 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 693746009929 tetramer interface [polypeptide binding]; other site 693746009930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746009931 catalytic residue [active] 693746009932 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 693746009933 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746009934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746009935 active site 693746009936 phosphorylation site [posttranslational modification] 693746009937 intermolecular recognition site; other site 693746009938 dimerization interface [polypeptide binding]; other site 693746009939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746009940 DNA binding site [nucleotide binding] 693746009941 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 693746009942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746009943 dimer interface [polypeptide binding]; other site 693746009944 phosphorylation site [posttranslational modification] 693746009945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746009946 ATP binding site [chemical binding]; other site 693746009947 Mg2+ binding site [ion binding]; other site 693746009948 G-X-G motif; other site 693746009949 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746009950 Integrase core domain; Region: rve; pfam00665 693746009951 Integrase core domain; Region: rve_3; cl15866 693746009952 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746009953 Transposase; Region: HTH_Tnp_1; cl17663 693746009954 Amidinotransferase; Region: Amidinotransf; cl19186 693746009955 ornithine carbamoyltransferase; Validated; Region: PRK02102 693746009956 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 693746009957 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 693746009958 EDD domain protein, DegV family; Region: DegV; TIGR00762 693746009959 potential frameshift: common BLAST hit: gi|160881444|ref|YP_001560412.1| MATE efflux family protein 693746009960 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746009961 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746009962 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 693746009963 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 693746009964 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 693746009965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746009966 active site 693746009967 motif I; other site 693746009968 motif II; other site 693746009969 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 693746009970 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 693746009971 peptide binding site [polypeptide binding]; other site 693746009972 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746009973 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 693746009974 metal binding site [ion binding]; metal-binding site 693746009975 dimer interface [polypeptide binding]; other site 693746009976 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 693746009977 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 693746009978 active site 693746009979 Riboflavin kinase; Region: Flavokinase; smart00904 693746009980 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 693746009981 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 693746009982 RNA binding site [nucleotide binding]; other site 693746009983 active site 693746009984 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 693746009985 DHH family; Region: DHH; pfam01368 693746009986 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 693746009987 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693746009988 translation initiation factor IF-2; Validated; Region: infB; PRK05306 693746009989 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 693746009990 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 693746009991 G1 box; other site 693746009992 putative GEF interaction site [polypeptide binding]; other site 693746009993 GTP/Mg2+ binding site [chemical binding]; other site 693746009994 Switch I region; other site 693746009995 G2 box; other site 693746009996 G3 box; other site 693746009997 Switch II region; other site 693746009998 G4 box; other site 693746009999 G5 box; other site 693746010000 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 693746010001 Translation-initiation factor 2; Region: IF-2; pfam11987 693746010002 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 693746010003 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 693746010004 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 693746010005 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 693746010006 putative RNA binding cleft [nucleotide binding]; other site 693746010007 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 693746010008 NusA N-terminal domain; Region: NusA_N; pfam08529 693746010009 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 693746010010 RNA binding site [nucleotide binding]; other site 693746010011 homodimer interface [polypeptide binding]; other site 693746010012 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693746010013 G-X-X-G motif; other site 693746010014 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 693746010015 G-X-X-G motif; other site 693746010016 Sm and related proteins; Region: Sm_like; cl00259 693746010017 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 693746010018 putative oligomer interface [polypeptide binding]; other site 693746010019 putative RNA binding site [nucleotide binding]; other site 693746010020 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 693746010021 ABC-ATPase subunit interface; other site 693746010022 dimer interface [polypeptide binding]; other site 693746010023 putative PBP binding regions; other site 693746010024 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 693746010025 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 693746010026 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 693746010027 metal binding site 2 [ion binding]; metal-binding site 693746010028 putative DNA binding helix; other site 693746010029 metal binding site 1 [ion binding]; metal-binding site 693746010030 dimer interface [polypeptide binding]; other site 693746010031 structural Zn2+ binding site [ion binding]; other site 693746010032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 693746010033 active site 693746010034 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 693746010035 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 693746010036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746010037 putative active site [active] 693746010038 heme pocket [chemical binding]; other site 693746010039 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 693746010040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746010041 ATP binding site [chemical binding]; other site 693746010042 Mg2+ binding site [ion binding]; other site 693746010043 G-X-G motif; other site 693746010044 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 693746010045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010046 active site 693746010047 phosphorylation site [posttranslational modification] 693746010048 intermolecular recognition site; other site 693746010049 dimerization interface [polypeptide binding]; other site 693746010050 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 693746010051 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 693746010052 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 693746010053 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 693746010054 active site 693746010055 metal binding site [ion binding]; metal-binding site 693746010056 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 693746010057 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 693746010058 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746010059 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 693746010060 metal binding site [ion binding]; metal-binding site 693746010061 dimer interface [polypeptide binding]; other site 693746010062 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 693746010063 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 693746010064 active site 693746010065 nucleophile elbow; other site 693746010066 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 693746010067 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693746010068 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 693746010069 PhoU domain; Region: PhoU; pfam01895 693746010070 PhoU domain; Region: PhoU; pfam01895 693746010071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 693746010072 Nucleoside recognition; Region: Gate; pfam07670 693746010073 FtsH Extracellular; Region: FtsH_ext; pfam06480 693746010074 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 693746010075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746010076 Walker A motif; other site 693746010077 ATP binding site [chemical binding]; other site 693746010078 Walker B motif; other site 693746010079 arginine finger; other site 693746010080 Peptidase family M41; Region: Peptidase_M41; pfam01434 693746010081 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 693746010082 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 693746010083 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 693746010084 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 693746010085 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 693746010086 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 693746010087 dimer interface [polypeptide binding]; other site 693746010088 putative CheW interface [polypeptide binding]; other site 693746010089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746010090 PAS domain; Region: PAS_9; pfam13426 693746010091 putative active site [active] 693746010092 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 693746010093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746010094 Walker A motif; other site 693746010095 ATP binding site [chemical binding]; other site 693746010096 Walker B motif; other site 693746010097 arginine finger; other site 693746010098 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693746010099 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746010100 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 693746010101 DctM-like transporters; Region: DctM; pfam06808 693746010102 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746010103 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 693746010104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 693746010105 NAD(P) binding site [chemical binding]; other site 693746010106 active site 693746010107 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 693746010108 Coenzyme A transferase; Region: CoA_trans; smart00882 693746010109 Coenzyme A transferase; Region: CoA_trans; cl17247 693746010110 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 693746010111 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 693746010112 putative NAD(P) binding site [chemical binding]; other site 693746010113 catalytic Zn binding site [ion binding]; other site 693746010114 structural Zn binding site [ion binding]; other site 693746010115 Creatinine amidohydrolase; Region: Creatininase; pfam02633 693746010116 putative acyltransferase; Provisional; Region: PRK05790 693746010117 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 693746010118 dimer interface [polypeptide binding]; other site 693746010119 active site 693746010120 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 693746010121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 693746010122 substrate binding site [chemical binding]; other site 693746010123 oxyanion hole (OAH) forming residues; other site 693746010124 trimer interface [polypeptide binding]; other site 693746010125 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 693746010126 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 693746010127 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 693746010128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 693746010129 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 693746010130 FAD binding site [chemical binding]; other site 693746010131 homotetramer interface [polypeptide binding]; other site 693746010132 substrate binding pocket [chemical binding]; other site 693746010133 catalytic base [active] 693746010134 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 693746010135 Ligand binding site [chemical binding]; other site 693746010136 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 693746010137 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 693746010138 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 693746010139 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 693746010140 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746010141 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746010142 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 693746010143 catalytic residues [active] 693746010144 dimer interface [polypeptide binding]; other site 693746010145 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 693746010146 Ferritin-like domain; Region: Ferritin; pfam00210 693746010147 ferroxidase diiron center [ion binding]; other site 693746010148 Rubrerythrin [Energy production and conversion]; Region: COG1592 693746010149 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 693746010150 binuclear metal center [ion binding]; other site 693746010151 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 693746010152 iron binding site [ion binding]; other site 693746010153 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 693746010154 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 693746010155 non-heme iron binding site [ion binding]; other site 693746010156 dimer interface [polypeptide binding]; other site 693746010157 Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014 693746010158 non-heme iron binding site [ion binding]; other site 693746010159 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 693746010160 FMN binding site [chemical binding]; other site 693746010161 dimer interface [polypeptide binding]; other site 693746010162 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 693746010163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 693746010164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 693746010165 Rubredoxin [Energy production and conversion]; Region: COG1773 693746010166 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 693746010167 iron binding site [ion binding]; other site 693746010168 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 693746010169 putative active site [active] 693746010170 putative metal binding site [ion binding]; other site 693746010171 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 693746010172 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 693746010173 FMN binding site [chemical binding]; other site 693746010174 substrate binding site [chemical binding]; other site 693746010175 putative catalytic residue [active] 693746010176 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 693746010177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 693746010178 S-layer homology domain; Region: SLH; pfam00395 693746010179 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 693746010180 oligomerization interface [polypeptide binding]; other site 693746010181 active site 693746010182 metal binding site [ion binding]; metal-binding site 693746010183 DctM-like transporters; Region: DctM; pfam06808 693746010184 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746010185 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746010186 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 693746010187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746010188 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746010189 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746010190 dimerization interface [polypeptide binding]; other site 693746010191 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 693746010192 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 693746010193 dimer interface [polypeptide binding]; other site 693746010194 active site 693746010195 glycine loop; other site 693746010196 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 693746010197 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746010198 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 693746010199 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 693746010200 aldehyde dehydrogenase family 2 member; Region: PLN02466 693746010201 Glutamate binding site [chemical binding]; other site 693746010202 NAD binding site [chemical binding]; other site 693746010203 catalytic residues [active] 693746010204 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746010205 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 693746010206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010207 non-specific DNA binding site [nucleotide binding]; other site 693746010208 salt bridge; other site 693746010209 sequence-specific DNA binding site [nucleotide binding]; other site 693746010210 Cupin domain; Region: Cupin_2; pfam07883 693746010211 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 693746010212 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 693746010213 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 693746010214 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 693746010215 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 693746010216 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 693746010217 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 693746010218 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 693746010219 putative active site [active] 693746010220 putative metal binding site [ion binding]; other site 693746010221 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 693746010222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 693746010223 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 693746010224 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 693746010225 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 693746010226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746010227 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 693746010228 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 693746010229 conserved cys residue [active] 693746010230 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 693746010231 putative active site [active] 693746010232 putative CoA binding site [chemical binding]; other site 693746010233 nudix motif; other site 693746010234 metal binding site [ion binding]; metal-binding site 693746010235 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 693746010236 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 693746010237 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 693746010238 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 693746010239 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 693746010240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 693746010241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746010242 dimer interface [polypeptide binding]; other site 693746010243 conserved gate region; other site 693746010244 putative PBP binding loops; other site 693746010245 ABC-ATPase subunit interface; other site 693746010246 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 693746010247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746010248 dimer interface [polypeptide binding]; other site 693746010249 conserved gate region; other site 693746010250 putative PBP binding loops; other site 693746010251 ABC-ATPase subunit interface; other site 693746010252 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693746010253 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693746010254 Walker A/P-loop; other site 693746010255 ATP binding site [chemical binding]; other site 693746010256 Q-loop/lid; other site 693746010257 ABC transporter signature motif; other site 693746010258 Walker B; other site 693746010259 D-loop; other site 693746010260 H-loop/switch region; other site 693746010261 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693746010262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 693746010263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 693746010264 Walker A/P-loop; other site 693746010265 ATP binding site [chemical binding]; other site 693746010266 Q-loop/lid; other site 693746010267 ABC transporter signature motif; other site 693746010268 Walker B; other site 693746010269 D-loop; other site 693746010270 H-loop/switch region; other site 693746010271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 693746010272 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 693746010273 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746010274 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746010275 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 693746010276 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 693746010277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746010278 putative active site [active] 693746010279 heme pocket [chemical binding]; other site 693746010280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 693746010281 putative active site [active] 693746010282 heme pocket [chemical binding]; other site 693746010283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746010284 dimer interface [polypeptide binding]; other site 693746010285 phosphorylation site [posttranslational modification] 693746010286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746010287 ATP binding site [chemical binding]; other site 693746010288 Mg2+ binding site [ion binding]; other site 693746010289 G-X-G motif; other site 693746010290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010291 active site 693746010292 phosphorylation site [posttranslational modification] 693746010293 intermolecular recognition site; other site 693746010294 dimerization interface [polypeptide binding]; other site 693746010295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010296 active site 693746010297 phosphorylation site [posttranslational modification] 693746010298 intermolecular recognition site; other site 693746010299 dimerization interface [polypeptide binding]; other site 693746010300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010301 active site 693746010302 phosphorylation site [posttranslational modification] 693746010303 intermolecular recognition site; other site 693746010304 dimerization interface [polypeptide binding]; other site 693746010305 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 693746010306 metal binding site [ion binding]; metal-binding site 693746010307 nucleotidyl binding site; other site 693746010308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 693746010309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746010310 metal binding site [ion binding]; metal-binding site 693746010311 active site 693746010312 I-site; other site 693746010313 integron integrase; Region: integrase_gron; TIGR02249 693746010314 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693746010315 active site 693746010316 Int/Topo IB signature motif; other site 693746010317 catalytic residues [active] 693746010318 DNA binding site [nucleotide binding] 693746010319 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 693746010320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746010321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746010322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746010323 dimerization interface [polypeptide binding]; other site 693746010324 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693746010325 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693746010326 transmembrane helices; other site 693746010327 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 693746010328 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746010329 ligand binding site [chemical binding]; other site 693746010330 NAD binding site [chemical binding]; other site 693746010331 catalytic site [active] 693746010332 hypothetical protein; Validated; Region: PRK06201 693746010333 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 693746010334 Catalytic site [active] 693746010335 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746010336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010337 non-specific DNA binding site [nucleotide binding]; other site 693746010338 salt bridge; other site 693746010339 sequence-specific DNA binding site [nucleotide binding]; other site 693746010340 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 693746010341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746010342 Siphovirus ReqiPepy6 Gp37-like protein; Region: Sipho_Gp37; pfam14594 693746010343 Phage tail protein; Region: Sipho_tail; pfam05709 693746010344 membrane protein P6; Region: PHA01399 693746010345 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 693746010346 Domain of unknown function DUF20; Region: UPF0118; cl00465 693746010347 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 693746010348 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 693746010349 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 693746010350 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 693746010351 oligomerization interface [polypeptide binding]; other site 693746010352 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 693746010353 Phage capsid family; Region: Phage_capsid; pfam05065 693746010354 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 693746010355 oligomer interface [polypeptide binding]; other site 693746010356 active site residues [active] 693746010357 Phage portal protein; Region: Phage_portal; pfam04860 693746010358 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746010359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746010360 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746010361 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 693746010362 Phage Terminase; Region: Terminase_1; cl19862 693746010363 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 693746010364 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693746010365 cofactor binding site; other site 693746010366 DNA binding site [nucleotide binding] 693746010367 substrate interaction site [chemical binding]; other site 693746010368 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 693746010369 ParB-like nuclease domain; Region: ParB; smart00470 693746010370 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 693746010371 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 693746010372 Phage terminase, small subunit; Region: Terminase_4; cl01525 693746010373 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 693746010374 active site 693746010375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746010376 DNA binding residues [nucleotide binding] 693746010377 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 693746010378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746010379 putative Mg++ binding site [ion binding]; other site 693746010380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746010381 nucleotide binding region [chemical binding]; other site 693746010382 ATP-binding site [chemical binding]; other site 693746010383 VRR-NUC domain; Region: VRR_NUC; pfam08774 693746010384 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 693746010385 Domain of unknown function (DUF927); Region: DUF927; cl12098 693746010386 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 693746010387 catalytic site [active] 693746010388 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 693746010389 active site 693746010390 DNA binding site [nucleotide binding] 693746010391 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 693746010392 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 693746010393 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746010394 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746010395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746010396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010397 non-specific DNA binding site [nucleotide binding]; other site 693746010398 salt bridge; other site 693746010399 sequence-specific DNA binding site [nucleotide binding]; other site 693746010400 Domain of unknown function (DUF955); Region: DUF955; cl01076 693746010401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010402 sequence-specific DNA binding site [nucleotide binding]; other site 693746010403 salt bridge; other site 693746010404 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 693746010405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746010406 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 693746010407 Walker A motif; other site 693746010408 ATP binding site [chemical binding]; other site 693746010409 Walker B motif; other site 693746010410 arginine finger; other site 693746010411 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 693746010412 cofactor binding site; other site 693746010413 DNA binding site [nucleotide binding] 693746010414 substrate interaction site [chemical binding]; other site 693746010415 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693746010416 cofactor binding site; other site 693746010417 DNA binding site [nucleotide binding] 693746010418 substrate interaction site [chemical binding]; other site 693746010419 DNA binding domain, excisionase family; Region: excise; TIGR01764 693746010420 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 693746010421 catalytic core [active] 693746010422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 693746010423 Coenzyme A binding pocket [chemical binding]; other site 693746010424 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 693746010425 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693746010426 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 693746010427 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693746010428 active site 693746010429 motif 2; other site 693746010430 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 693746010431 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 693746010432 histidinol dehydrogenase; Region: hisD; TIGR00069 693746010433 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 693746010434 NAD binding site [chemical binding]; other site 693746010435 dimerization interface [polypeptide binding]; other site 693746010436 product binding site; other site 693746010437 substrate binding site [chemical binding]; other site 693746010438 zinc binding site [ion binding]; other site 693746010439 catalytic residues [active] 693746010440 histidinol-phosphate aminotransferase; Provisional; Region: PRK05387 693746010441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746010442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746010443 homodimer interface [polypeptide binding]; other site 693746010444 catalytic residue [active] 693746010445 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 693746010446 putative active site pocket [active] 693746010447 4-fold oligomerization interface [polypeptide binding]; other site 693746010448 metal binding residues [ion binding]; metal-binding site 693746010449 3-fold/trimer interface [polypeptide binding]; other site 693746010450 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 693746010451 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 693746010452 putative active site [active] 693746010453 oxyanion strand; other site 693746010454 catalytic triad [active] 693746010455 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 693746010456 catalytic residues [active] 693746010457 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693746010458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746010459 S-adenosylmethionine binding site [chemical binding]; other site 693746010460 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 693746010461 substrate binding site [chemical binding]; other site 693746010462 glutamase interaction surface [polypeptide binding]; other site 693746010463 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 693746010464 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 693746010465 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 693746010466 metal binding site [ion binding]; metal-binding site 693746010467 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 693746010468 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 693746010469 active site 693746010470 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 693746010471 dimerization domain swap beta strand [polypeptide binding]; other site 693746010472 regulatory protein interface [polypeptide binding]; other site 693746010473 active site 693746010474 regulatory phosphorylation site [posttranslational modification]; other site 693746010475 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 693746010476 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 693746010477 GIY-YIG motif/motif A; other site 693746010478 active site 693746010479 catalytic site [active] 693746010480 putative DNA binding site [nucleotide binding]; other site 693746010481 metal binding site [ion binding]; metal-binding site 693746010482 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 693746010483 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 693746010484 Sulfatase; Region: Sulfatase; cl19157 693746010485 Putative motility protein; Region: YjfB_motility; pfam14070 693746010486 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 693746010487 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746010488 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746010489 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693746010490 DNA binding residues [nucleotide binding] 693746010491 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 693746010492 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 693746010493 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 693746010494 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693746010495 catalytic triad [active] 693746010496 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 693746010497 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 693746010498 catalytic triad [active] 693746010499 Integrase core domain; Region: rve_2; pfam13333 693746010500 putative transposase OrfB; Reviewed; Region: PHA02517 693746010501 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746010502 Transposase; Region: HTH_Tnp_1; cl17663 693746010503 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 693746010504 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 693746010505 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 693746010506 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 693746010507 Int/Topo IB signature motif; other site 693746010508 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746010509 Resolvase, N terminal domain; Region: Resolvase; smart00857 693746010510 catalytic residues [active] 693746010511 catalytic nucleophile [active] 693746010512 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746010513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 693746010514 DNA binding residues [nucleotide binding] 693746010515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010516 non-specific DNA binding site [nucleotide binding]; other site 693746010517 salt bridge; other site 693746010518 sequence-specific DNA binding site [nucleotide binding]; other site 693746010519 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 693746010520 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746010521 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 693746010522 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 693746010523 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 693746010524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010525 salt bridge; other site 693746010526 non-specific DNA binding site [nucleotide binding]; other site 693746010527 sequence-specific DNA binding site [nucleotide binding]; other site 693746010528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746010529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746010530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746010531 CHC2 zinc finger; Region: zf-CHC2; cl17510 693746010532 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 693746010533 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 693746010534 active site 693746010535 metal binding site [ion binding]; metal-binding site 693746010536 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 693746010537 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746010538 Sel1-like repeats; Region: SEL1; smart00671 693746010539 Sel1-like repeats; Region: SEL1; smart00671 693746010540 Sel1-like repeats; Region: SEL1; smart00671 693746010541 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746010542 Sel1-like repeats; Region: SEL1; smart00671 693746010543 Sel1-like repeats; Region: SEL1; smart00671 693746010544 Sel1-like repeats; Region: SEL1; smart00671 693746010545 Sel1-like repeats; Region: SEL1; smart00671 693746010546 Sel1-like repeats; Region: SEL1; smart00671 693746010547 Sel1-like repeats; Region: SEL1; smart00671 693746010548 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 693746010549 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 693746010550 Mg binding site [ion binding]; other site 693746010551 nucleotide binding site [chemical binding]; other site 693746010552 putative protofilament interface [polypeptide binding]; other site 693746010553 valyl-tRNA synthetase-like protein; Provisional; Region: PTZ00419 693746010554 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746010555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010556 non-specific DNA binding site [nucleotide binding]; other site 693746010557 salt bridge; other site 693746010558 sequence-specific DNA binding site [nucleotide binding]; other site 693746010559 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 693746010560 Eukaryotic rRNA processing protein EBP2; Region: Ebp2; pfam05890 693746010561 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693746010562 putative active site pocket [active] 693746010563 dimerization interface [polypeptide binding]; other site 693746010564 putative catalytic residue [active] 693746010565 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 693746010566 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 693746010567 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 693746010568 Ligand Binding Site [chemical binding]; other site 693746010569 AAA-like domain; Region: AAA_10; pfam12846 693746010570 NTPase; Region: NTPase_1; cl17478 693746010571 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693746010572 cofactor binding site; other site 693746010573 DNA binding site [nucleotide binding] 693746010574 substrate interaction site [chemical binding]; other site 693746010575 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 693746010576 Putative lysophospholipase; Region: Hydrolase_4; cl19140 693746010577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 693746010578 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 693746010579 Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934 693746010580 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 693746010581 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 693746010582 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746010583 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746010584 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746010585 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 693746010586 Walker A motif; other site 693746010587 ATP binding site [chemical binding]; other site 693746010588 Walker B motif; other site 693746010589 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 693746010590 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746010591 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693746010592 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 693746010593 SpoVG; Region: SpoVG; pfam04026 693746010594 Protein of unknown function (DUF3849); Region: DUF3849; pfam12960 693746010595 YodL-like; Region: YodL; pfam14191 693746010596 potential frameshift: common BLAST hit: gi|258514744|ref|YP_003190966.1| S-layer domain-containing protein 693746010597 S-layer homology domain; Region: SLH; pfam00395 693746010598 S-layer homology domain; Region: SLH; pfam00395 693746010599 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693746010600 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 693746010601 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 693746010602 Fic family protein [Function unknown]; Region: COG3177 693746010603 Fic/DOC family; Region: Fic; pfam02661 693746010604 Antirestriction protein (ArdA); Region: ArdA; cl01953 693746010605 Antirestriction protein (ArdA); Region: ArdA; cl01953 693746010606 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 693746010607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 693746010608 HTH-like domain; Region: HTH_21; pfam13276 693746010609 Integrase core domain; Region: rve; pfam00665 693746010610 Integrase core domain; Region: rve_3; pfam13683 693746010611 Transposase; Region: HTH_Tnp_1; cl17663 693746010612 potential frameshift: common BLAST hit: gi|208702230|ref|YP_002267406.1| IS3-family transposase, OrfB 693746010613 Integrase core domain; Region: rve; pfam00665 693746010614 Integrase core domain; Region: rve_3; cl15866 693746010615 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 693746010616 cofactor binding site; other site 693746010617 DNA binding site [nucleotide binding] 693746010618 substrate interaction site [chemical binding]; other site 693746010619 BpuSI N-terminal domain; Region: BpuSI_N; pfam15516 693746010620 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 693746010621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746010622 S-adenosylmethionine binding site [chemical binding]; other site 693746010623 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 693746010624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746010625 S-adenosylmethionine binding site [chemical binding]; other site 693746010626 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746010627 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 693746010628 putative DNA binding site [nucleotide binding]; other site 693746010629 putative Zn2+ binding site [ion binding]; other site 693746010630 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 693746010631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 693746010632 ATP binding site [chemical binding]; other site 693746010633 putative Mg++ binding site [ion binding]; other site 693746010634 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 693746010635 nucleotide binding region [chemical binding]; other site 693746010636 ATP-binding site [chemical binding]; other site 693746010637 VRR-NUC domain; Region: VRR_NUC; pfam08774 693746010638 Virulence-associated protein E; Region: VirE; pfam05272 693746010639 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 693746010640 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 693746010641 active site 693746010642 DNA binding site [nucleotide binding] 693746010643 catalytic site [active] 693746010644 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 693746010645 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 693746010646 HNH endonuclease; Region: HNH_3; pfam13392 693746010647 AP2 domain; Region: AP2; pfam00847 693746010648 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 693746010649 Helix-turn-helix domain; Region: HTH_17; pfam12728 693746010650 3D domain; Region: 3D; cl01439 693746010651 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 693746010652 DNA binding residues [nucleotide binding] 693746010653 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746010654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010655 non-specific DNA binding site [nucleotide binding]; other site 693746010656 salt bridge; other site 693746010657 sequence-specific DNA binding site [nucleotide binding]; other site 693746010658 Domain of unknown function (DUF955); Region: DUF955; cl01076 693746010659 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 693746010660 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 693746010661 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 693746010662 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 693746010663 active site 693746010664 catalytic residues [active] 693746010665 DNA binding site [nucleotide binding] 693746010666 Int/Topo IB signature motif; other site 693746010667 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746010668 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746010669 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 693746010670 active site 693746010671 Zn binding site [ion binding]; other site 693746010672 DctM-like transporters; Region: DctM; pfam06808 693746010673 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 693746010674 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 693746010675 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 693746010676 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 693746010677 sec-independent translocase; Provisional; Region: PRK04654 693746010678 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 693746010679 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746010680 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 693746010681 active site 693746010682 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 693746010683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010684 active site 693746010685 phosphorylation site [posttranslational modification] 693746010686 intermolecular recognition site; other site 693746010687 dimerization interface [polypeptide binding]; other site 693746010688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746010689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746010690 dimer interface [polypeptide binding]; other site 693746010691 phosphorylation site [posttranslational modification] 693746010692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746010693 ATP binding site [chemical binding]; other site 693746010694 Mg2+ binding site [ion binding]; other site 693746010695 G-X-G motif; other site 693746010696 poly-gamma-glutamate system protein; Region: gamma_Glu_sys; TIGR04332 693746010697 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 693746010698 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 693746010699 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 693746010700 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693746010701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010702 active site 693746010703 phosphorylation site [posttranslational modification] 693746010704 intermolecular recognition site; other site 693746010705 dimerization interface [polypeptide binding]; other site 693746010706 Protein of unknown function (DUF342); Region: DUF342; pfam03961 693746010707 S-layer homology domain; Region: SLH; pfam00395 693746010708 S-layer homology domain; Region: SLH; pfam00395 693746010709 Probable zinc-binding domain; Region: zf-trcl; pfam13451 693746010710 CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272 693746010711 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 693746010712 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 693746010713 acyl-activating enzyme (AAE) consensus motif; other site 693746010714 active site 693746010715 AMP binding site [chemical binding]; other site 693746010716 CoA binding site [chemical binding]; other site 693746010717 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 693746010718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746010719 FeS/SAM binding site; other site 693746010720 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 693746010721 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693746010722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746010723 S-adenosylmethionine binding site [chemical binding]; other site 693746010724 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746010725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 693746010726 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 693746010727 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 693746010728 Cysteine-rich domain; Region: CCG; pfam02754 693746010729 Cysteine-rich domain; Region: CCG; pfam02754 693746010730 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 693746010731 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 693746010732 catalytic loop [active] 693746010733 iron binding site [ion binding]; other site 693746010734 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 693746010735 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 693746010736 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 693746010737 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 693746010738 putative active site [active] 693746010739 metal binding site [ion binding]; metal-binding site 693746010740 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 693746010741 nudix motif; other site 693746010742 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 693746010743 Dehydratase family; Region: ILVD_EDD; cl00340 693746010744 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 693746010745 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746010746 dimerization interface [polypeptide binding]; other site 693746010747 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746010748 dimer interface [polypeptide binding]; other site 693746010749 phosphorylation site [posttranslational modification] 693746010750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746010751 ATP binding site [chemical binding]; other site 693746010752 Mg2+ binding site [ion binding]; other site 693746010753 G-X-G motif; other site 693746010754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 693746010755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746010756 active site 693746010757 phosphorylation site [posttranslational modification] 693746010758 intermolecular recognition site; other site 693746010759 dimerization interface [polypeptide binding]; other site 693746010760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746010761 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746010762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746010763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746010764 dimerization interface [polypeptide binding]; other site 693746010765 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 693746010766 Histidine kinase; Region: His_kinase; pfam06580 693746010767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746010768 ATP binding site [chemical binding]; other site 693746010769 Mg2+ binding site [ion binding]; other site 693746010770 G-X-G motif; other site 693746010771 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 693746010772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746010773 dimer interface [polypeptide binding]; other site 693746010774 conserved gate region; other site 693746010775 putative PBP binding loops; other site 693746010776 ABC-ATPase subunit interface; other site 693746010777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 693746010778 dimer interface [polypeptide binding]; other site 693746010779 conserved gate region; other site 693746010780 putative PBP binding loops; other site 693746010781 ABC-ATPase subunit interface; other site 693746010782 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 693746010783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746010784 Walker A/P-loop; other site 693746010785 ATP binding site [chemical binding]; other site 693746010786 Q-loop/lid; other site 693746010787 ABC transporter signature motif; other site 693746010788 Walker B; other site 693746010789 D-loop; other site 693746010790 H-loop/switch region; other site 693746010791 TOBE domain; Region: TOBE_2; pfam08402 693746010792 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 693746010793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746010794 Transposase; Region: HTH_Tnp_1; cl17663 693746010795 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746010796 HTH-like domain; Region: HTH_21; pfam13276 693746010797 Integrase core domain; Region: rve; pfam00665 693746010798 Integrase core domain; Region: rve_3; cl15866 693746010799 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 693746010800 Propionate catabolism activator; Region: PrpR_N; pfam06506 693746010801 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 693746010802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 693746010803 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693746010804 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 693746010805 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 693746010806 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 693746010807 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 693746010808 Glutamine amidotransferase class-I; Region: GATase; pfam00117 693746010809 glutamine binding [chemical binding]; other site 693746010810 catalytic triad [active] 693746010811 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 693746010812 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 693746010813 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 693746010814 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 693746010815 active site 693746010816 ribulose/triose binding site [chemical binding]; other site 693746010817 phosphate binding site [ion binding]; other site 693746010818 substrate (anthranilate) binding pocket [chemical binding]; other site 693746010819 product (indole) binding pocket [chemical binding]; other site 693746010820 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 693746010821 active site 693746010822 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 693746010823 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 693746010824 substrate binding site [chemical binding]; other site 693746010825 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 693746010826 substrate binding site [chemical binding]; other site 693746010827 ligand binding site [chemical binding]; other site 693746010828 2-isopropylmalate synthase; Validated; Region: PRK00915 693746010829 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 693746010830 active site 693746010831 catalytic residues [active] 693746010832 metal binding site [ion binding]; metal-binding site 693746010833 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 693746010834 Helix-turn-helix domain; Region: HTH_38; pfam13936 693746010835 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 693746010836 Integrase core domain; Region: rve; pfam00665 693746010837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746010838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746010839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746010840 dimerization interface [polypeptide binding]; other site 693746010841 Creatinine amidohydrolase; Region: Creatininase; pfam02633 693746010842 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 693746010843 DctM-like transporters; Region: DctM; pfam06808 693746010844 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 693746010845 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 693746010846 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 693746010847 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 693746010848 metal binding site [ion binding]; metal-binding site 693746010849 dimer interface [polypeptide binding]; other site 693746010850 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 693746010851 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 693746010852 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 693746010853 WG containing repeat; Region: WG_beta_rep; pfam14903 693746010854 Sulfate transporter family; Region: Sulfate_transp; cl19250 693746010855 xanthine permease; Region: pbuX; TIGR03173 693746010856 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 693746010857 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693746010858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 693746010859 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 693746010860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 693746010861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 693746010862 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 693746010863 dimerization interface [polypeptide binding]; other site 693746010864 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 693746010865 A new structural DNA glycosylase; Region: AlkD_like; cl11434 693746010866 active site 693746010867 A new structural DNA glycosylase; Region: AlkD_like; cl11434 693746010868 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 693746010869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746010870 FeS/SAM binding site; other site 693746010871 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 693746010872 active site 693746010873 TfoX N-terminal domain; Region: TfoX_N; pfam04993 693746010874 Transposase domain (DUF772); Region: DUF772; pfam05598 693746010875 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 693746010876 putative transposase OrfB; Reviewed; Region: PHA02517 693746010877 HTH-like domain; Region: HTH_21; pfam13276 693746010878 Integrase core domain; Region: rve; pfam00665 693746010879 Integrase core domain; Region: rve_3; cl15866 693746010880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746010881 Transposase; Region: HTH_Tnp_1; cl17663 693746010882 GTPase RsgA; Reviewed; Region: PRK01889 693746010883 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 693746010884 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 693746010885 GTPase/Zn-binding domain interface [polypeptide binding]; other site 693746010886 GTP/Mg2+ binding site [chemical binding]; other site 693746010887 G4 box; other site 693746010888 G5 box; other site 693746010889 G1 box; other site 693746010890 Switch I region; other site 693746010891 G2 box; other site 693746010892 G3 box; other site 693746010893 Switch II region; other site 693746010894 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 693746010895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746010896 S-adenosylmethionine binding site [chemical binding]; other site 693746010897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 693746010898 Transposase; Region: HTH_Tnp_1; cl17663 693746010899 potential frameshift: common BLAST hit: gi|302340425|ref|YP_003805631.1| Integrase catalytic subunit 693746010900 HTH-like domain; Region: HTH_21; pfam13276 693746010901 Integrase core domain; Region: rve; pfam00665 693746010902 Integrase core domain; Region: rve_3; cl15866 693746010903 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 693746010904 Penicillinase repressor; Region: Penicillinase_R; cl17580 693746010905 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 693746010906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 693746010907 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 693746010908 VanZ like family; Region: VanZ; pfam04892 693746010909 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746010910 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746010911 catalytic residues [active] 693746010912 catalytic nucleophile [active] 693746010913 Recombinase; Region: Recombinase; pfam07508 693746010914 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746010915 Recombinase; Region: Recombinase; pfam07508 693746010916 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746010917 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746010918 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746010919 catalytic residues [active] 693746010920 catalytic nucleophile [active] 693746010921 Recombinase; Region: Recombinase; pfam07508 693746010922 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746010923 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746010924 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 693746010925 catalytic residues [active] 693746010926 PemK-like protein; Region: PemK; pfam02452 693746010927 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 693746010928 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693746010929 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 693746010930 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 693746010931 DNA binding residues [nucleotide binding] 693746010932 drug binding residues [chemical binding]; other site 693746010933 dimer interface [polypeptide binding]; other site 693746010934 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693746010935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746010936 H+ Antiporter protein; Region: 2A0121; TIGR00900 693746010937 putative substrate translocation pore; other site 693746010938 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 693746010939 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 693746010940 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 693746010941 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746010942 Walker A/P-loop; other site 693746010943 ATP binding site [chemical binding]; other site 693746010944 Q-loop/lid; other site 693746010945 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 693746010946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 693746010947 Walker A/P-loop; other site 693746010948 ATP binding site [chemical binding]; other site 693746010949 Q-loop/lid; other site 693746010950 ABC transporter signature motif; other site 693746010951 Walker B; other site 693746010952 D-loop; other site 693746010953 H-loop/switch region; other site 693746010954 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746010955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746010956 non-specific DNA binding site [nucleotide binding]; other site 693746010957 salt bridge; other site 693746010958 sequence-specific DNA binding site [nucleotide binding]; other site 693746010959 Helix-turn-helix domain; Region: HTH_36; pfam13730 693746010960 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 693746010961 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 693746010962 Walker A motif; other site 693746010963 ATP binding site [chemical binding]; other site 693746010964 Walker B motif; other site 693746010965 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 693746010966 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 693746010967 Toprim-like; Region: Toprim_2; pfam13155 693746010968 active site 693746010969 metal binding site [ion binding]; metal-binding site 693746010970 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746010971 Sel1-like repeats; Region: SEL1; smart00671 693746010972 Sel1-like repeats; Region: SEL1; smart00671 693746010973 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 693746010974 Sel1-like repeats; Region: SEL1; smart00671 693746010975 Sel1-like repeats; Region: SEL1; smart00671 693746010976 Sel1-like repeats; Region: SEL1; smart00671 693746010977 Sel1-like repeats; Region: SEL1; smart00671 693746010978 Sel1-like repeats; Region: SEL1; smart00671 693746010979 Sel1-like repeats; Region: SEL1; smart00671 693746010980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746010981 DNA-binding site [nucleotide binding]; DNA binding site 693746010982 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 693746010983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746010984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746010985 homodimer interface [polypeptide binding]; other site 693746010986 catalytic residue [active] 693746010987 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 693746010988 EamA-like transporter family; Region: EamA; pfam00892 693746010989 EamA-like transporter family; Region: EamA; pfam00892 693746010990 B3/4 domain; Region: B3_4; cl19243 693746010991 potential frameshift: common BLAST hit: gi|153939553|ref|YP_001390076.1| AraC family transcriptional regulator 693746010992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746010993 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 693746010994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746010995 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 693746010996 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 693746010997 Protein of unknown function (DUF1152); Region: DUF1152; cl19851 693746010998 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 693746010999 Peptidase family M23; Region: Peptidase_M23; pfam01551 693746011000 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 693746011001 putative active site pocket [active] 693746011002 dimerization interface [polypeptide binding]; other site 693746011003 putative catalytic residue [active] 693746011004 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 693746011005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011006 AAA-like domain; Region: AAA_10; pfam12846 693746011007 Domain of unknown function DUF87; Region: DUF87; cl19135 693746011008 Walker A motif; other site 693746011009 ATP binding site [chemical binding]; other site 693746011010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746011011 non-specific DNA binding site [nucleotide binding]; other site 693746011012 salt bridge; other site 693746011013 sequence-specific DNA binding site [nucleotide binding]; other site 693746011014 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 693746011015 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 693746011016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746011017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 693746011018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746011019 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693746011020 putative substrate translocation pore; other site 693746011021 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 693746011022 AAA domain; Region: AAA_17; cl19128 693746011023 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 693746011024 Protein of unknown function (DUF3852); Region: DUF3852; pfam12963 693746011025 DNA translocase FtsK; Provisional; Region: PRK10263 693746011026 Fungal Rad9-like Rad53-binding; Region: Rad9_Rad53_bind; pfam08605 693746011027 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 693746011028 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 693746011029 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 693746011030 Walker A motif; other site 693746011031 ATP binding site [chemical binding]; other site 693746011032 Walker B motif; other site 693746011033 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 693746011034 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746011035 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 693746011036 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 693746011037 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 693746011038 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 693746011039 putative active site [active] 693746011040 putative NTP binding site [chemical binding]; other site 693746011041 putative nucleic acid binding site [nucleotide binding]; other site 693746011042 Type II intron maturase; Region: Intron_maturas2; pfam01348 693746011043 SpoVG; Region: SpoVG; pfam04026 693746011044 YodL-like; Region: YodL; pfam14191 693746011045 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 693746011046 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 693746011047 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 693746011048 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746011049 Transposase, Mutator family; Region: Transposase_mut; cl19537 693746011050 potential frameshift: common BLAST hit: gi|284049350|ref|YP_003399689.1| D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein 693746011051 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746011052 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 693746011053 NAD binding site [chemical binding]; other site 693746011054 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746011055 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 693746011056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746011057 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 693746011058 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 693746011059 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 693746011060 putative active site [active] 693746011061 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 693746011062 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 693746011063 ligand binding site [chemical binding]; other site 693746011064 NAD binding site [chemical binding]; other site 693746011065 dimerization interface [polypeptide binding]; other site 693746011066 catalytic site [active] 693746011067 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746011068 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 693746011069 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 693746011070 transmembrane helices; other site 693746011071 hypothetical protein; Validated; Region: PRK06201 693746011072 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 693746011073 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 693746011074 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 693746011075 putative metallo-dependent hydrolase; Provisional; Region: PRK12394 693746011076 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746011077 active site 693746011078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 693746011079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 693746011080 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 693746011081 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 693746011082 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 693746011083 catalytic residues [active] 693746011084 catalytic nucleophile [active] 693746011085 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746011086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746011087 Integrase core domain; Region: rve; pfam00665 693746011088 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746011089 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746011090 transposase/IS protein; Provisional; Region: PRK09183 693746011091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011092 Walker A motif; other site 693746011093 ATP binding site [chemical binding]; other site 693746011094 Walker B motif; other site 693746011095 Recombinase; Region: Recombinase; pfam07508 693746011096 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 693746011097 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 693746011098 dimer interface [polypeptide binding]; other site 693746011099 pyridoxal binding site [chemical binding]; other site 693746011100 ATP binding site [chemical binding]; other site 693746011101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 693746011102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 693746011103 putative substrate translocation pore; other site 693746011104 Beta-lactamase; Region: Beta-lactamase; pfam00144 693746011105 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 693746011106 elongation factor G; Reviewed; Region: PRK12740 693746011107 G1 box; other site 693746011108 putative GEF interaction site [polypeptide binding]; other site 693746011109 GTP/Mg2+ binding site [chemical binding]; other site 693746011110 Switch I region; other site 693746011111 G2 box; other site 693746011112 G3 box; other site 693746011113 Switch II region; other site 693746011114 G4 box; other site 693746011115 G5 box; other site 693746011116 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 693746011117 Elongation Factor G, domain II; Region: EFG_II; pfam14492 693746011118 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 693746011119 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 693746011120 aspartate aminotransferase; Provisional; Region: PRK05764 693746011121 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 693746011122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 693746011123 homodimer interface [polypeptide binding]; other site 693746011124 catalytic residue [active] 693746011125 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 693746011126 DNA polymerase III subunit delta'; Validated; Region: PRK08485 693746011127 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 693746011128 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 693746011129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746011130 active site 693746011131 motif I; other site 693746011132 motif II; other site 693746011133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 693746011134 Predicted transcriptional regulators [Transcription]; Region: COG1725 693746011135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746011136 DNA-binding site [nucleotide binding]; DNA binding site 693746011137 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 693746011138 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746011139 Walker A/P-loop; other site 693746011140 ATP binding site [chemical binding]; other site 693746011141 Q-loop/lid; other site 693746011142 ABC transporter signature motif; other site 693746011143 Walker B; other site 693746011144 D-loop; other site 693746011145 H-loop/switch region; other site 693746011146 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 693746011147 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 693746011148 guanine deaminase; Region: guan_deamin; TIGR02967 693746011149 active site 693746011150 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 693746011151 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 693746011152 competence damage-inducible protein A; Provisional; Region: PRK00549 693746011153 putative MPT binding site; other site 693746011154 Competence-damaged protein; Region: CinA; pfam02464 693746011155 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 693746011156 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 693746011157 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 693746011158 Ligand Binding Site [chemical binding]; other site 693746011159 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 693746011160 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 693746011161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011162 Walker A motif; other site 693746011163 ATP binding site [chemical binding]; other site 693746011164 Walker B motif; other site 693746011165 arginine finger; other site 693746011166 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 693746011167 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 693746011168 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 693746011169 dimer interface [polypeptide binding]; other site 693746011170 PYR/PP interface [polypeptide binding]; other site 693746011171 TPP binding site [chemical binding]; other site 693746011172 substrate binding site [chemical binding]; other site 693746011173 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 693746011174 Domain of unknown function; Region: EKR; pfam10371 693746011175 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 693746011176 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 693746011177 TPP-binding site [chemical binding]; other site 693746011178 dimer interface [polypeptide binding]; other site 693746011179 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 693746011180 pyruvate phosphate dikinase; Provisional; Region: PRK09279 693746011181 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 693746011182 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 693746011183 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 693746011184 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 693746011185 Clp amino terminal domain; Region: Clp_N; pfam02861 693746011186 Clp amino terminal domain; Region: Clp_N; pfam02861 693746011187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011188 Walker A motif; other site 693746011189 ATP binding site [chemical binding]; other site 693746011190 Walker B motif; other site 693746011191 arginine finger; other site 693746011192 UvrB/uvrC motif; Region: UVR; pfam02151 693746011193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011194 Walker A motif; other site 693746011195 ATP binding site [chemical binding]; other site 693746011196 Walker B motif; other site 693746011197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 693746011198 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 693746011199 UvrB/uvrC motif; Region: UVR; pfam02151 693746011200 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 693746011201 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 693746011202 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 693746011203 Methyltransferase domain; Region: Methyltransf_26; pfam13659 693746011204 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 693746011205 putative SAM binding site [chemical binding]; other site 693746011206 putative homodimer interface [polypeptide binding]; other site 693746011207 S-layer homology domain; Region: SLH; pfam00395 693746011208 S-layer homology domain; Region: SLH; pfam00395 693746011209 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 693746011210 Transcriptional regulator [Transcription]; Region: LytR; COG1316 693746011211 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 693746011212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 693746011213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 693746011214 active site 693746011215 phosphorylation site [posttranslational modification] 693746011216 intermolecular recognition site; other site 693746011217 dimerization interface [polypeptide binding]; other site 693746011218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 693746011219 DNA binding site [nucleotide binding] 693746011220 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 693746011221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 693746011222 dimerization interface [polypeptide binding]; other site 693746011223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 693746011224 dimer interface [polypeptide binding]; other site 693746011225 phosphorylation site [posttranslational modification] 693746011226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746011227 ATP binding site [chemical binding]; other site 693746011228 Mg2+ binding site [ion binding]; other site 693746011229 G-X-G motif; other site 693746011230 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 693746011231 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 693746011232 protein binding site [polypeptide binding]; other site 693746011233 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 693746011234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 693746011235 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 693746011236 Predicted membrane protein [Function unknown]; Region: COG1511 693746011237 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 693746011238 MMPL family; Region: MMPL; cl14618 693746011239 MMPL family; Region: MMPL; cl14618 693746011240 potential frameshift: common BLAST hit: gi|317131920|ref|YP_004091234.1| Integrase catalytic region 693746011241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746011242 Integrase core domain; Region: rve; pfam00665 693746011243 potential frameshift: common BLAST hit: gi|317132204|ref|YP_004091518.1| Integrase catalytic region 693746011244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 693746011245 transposase/IS protein; Provisional; Region: PRK09183 693746011246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011247 Walker A motif; other site 693746011248 ATP binding site [chemical binding]; other site 693746011249 Walker B motif; other site 693746011250 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 693746011251 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 693746011252 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693746011253 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693746011254 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 693746011255 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 693746011256 ATP-grasp domain; Region: ATP-grasp_4; cl17255 693746011257 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 693746011258 substrate binding site [chemical binding]; other site 693746011259 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 693746011260 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693746011261 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 693746011262 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 693746011263 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 693746011264 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 693746011265 catalytic site [active] 693746011266 subunit interface [polypeptide binding]; other site 693746011267 GTP-binding protein LepA; Provisional; Region: PRK05433 693746011268 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 693746011269 G1 box; other site 693746011270 putative GEF interaction site [polypeptide binding]; other site 693746011271 GTP/Mg2+ binding site [chemical binding]; other site 693746011272 Switch I region; other site 693746011273 G2 box; other site 693746011274 G3 box; other site 693746011275 Switch II region; other site 693746011276 G4 box; other site 693746011277 G5 box; other site 693746011278 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 693746011279 Elongation Factor G, domain II; Region: EFG_II; pfam14492 693746011280 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 693746011281 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 693746011282 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 693746011283 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 693746011284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 693746011285 non-specific DNA binding site [nucleotide binding]; other site 693746011286 salt bridge; other site 693746011287 sequence-specific DNA binding site [nucleotide binding]; other site 693746011288 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 693746011289 DivIVA protein; Region: DivIVA; pfam05103 693746011290 Protein of unknown function (DUF552); Region: DUF552; pfam04472 693746011291 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 693746011292 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 693746011293 catalytic residue [active] 693746011294 HlyD family secretion protein; Region: HlyD_2; pfam12700 693746011295 putative membrane fusion protein; Region: TIGR02828 693746011296 bacterial Hfq-like; Region: Hfq; cd01716 693746011297 hexamer interface [polypeptide binding]; other site 693746011298 Sm1 motif; other site 693746011299 RNA binding site [nucleotide binding]; other site 693746011300 Sm2 motif; other site 693746011301 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 693746011302 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 693746011303 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 693746011304 ATP binding site [chemical binding]; other site 693746011305 Mg2+ binding site [ion binding]; other site 693746011306 G-X-G motif; other site 693746011307 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 693746011308 ATP binding site [chemical binding]; other site 693746011309 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 693746011310 CAAX protease self-immunity; Region: Abi; pfam02517 693746011311 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 693746011312 MutS domain I; Region: MutS_I; pfam01624 693746011313 MutS domain II; Region: MutS_II; pfam05188 693746011314 MutS domain III; Region: MutS_III; pfam05192 693746011315 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 693746011316 Walker A/P-loop; other site 693746011317 ATP binding site [chemical binding]; other site 693746011318 Q-loop/lid; other site 693746011319 ABC transporter signature motif; other site 693746011320 Walker B; other site 693746011321 D-loop; other site 693746011322 H-loop/switch region; other site 693746011323 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 693746011324 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 693746011325 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 693746011326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 693746011327 FeS/SAM binding site; other site 693746011328 TRAM domain; Region: TRAM; pfam01938 693746011329 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 693746011330 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 693746011331 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 693746011332 RNA binding surface [nucleotide binding]; other site 693746011333 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 693746011334 active site 693746011335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 693746011336 metal binding site [ion binding]; metal-binding site 693746011337 active site 693746011338 I-site; other site 693746011339 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 693746011340 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 693746011341 active site 693746011342 HIGH motif; other site 693746011343 KMSKS motif; other site 693746011344 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 693746011345 tRNA binding surface [nucleotide binding]; other site 693746011346 anticodon binding site; other site 693746011347 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 693746011348 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 693746011349 amidase catalytic site [active] 693746011350 Zn binding residues [ion binding]; other site 693746011351 substrate binding site [chemical binding]; other site 693746011352 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 693746011353 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 693746011354 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 693746011355 Walker A/P-loop; other site 693746011356 ATP binding site [chemical binding]; other site 693746011357 Q-loop/lid; other site 693746011358 ABC transporter signature motif; other site 693746011359 Walker B; other site 693746011360 D-loop; other site 693746011361 H-loop/switch region; other site 693746011362 Predicted transcriptional regulators [Transcription]; Region: COG1725 693746011363 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 693746011364 DNA-binding site [nucleotide binding]; DNA binding site 693746011365 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 693746011366 16S/18S rRNA binding site [nucleotide binding]; other site 693746011367 S13e-L30e interaction site [polypeptide binding]; other site 693746011368 25S rRNA binding site [nucleotide binding]; other site 693746011369 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 693746011370 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 693746011371 RNase E interface [polypeptide binding]; other site 693746011372 trimer interface [polypeptide binding]; other site 693746011373 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 693746011374 RNase E interface [polypeptide binding]; other site 693746011375 trimer interface [polypeptide binding]; other site 693746011376 active site 693746011377 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 693746011378 putative nucleic acid binding region [nucleotide binding]; other site 693746011379 G-X-X-G motif; other site 693746011380 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 693746011381 RNA binding site [nucleotide binding]; other site 693746011382 domain interface; other site 693746011383 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 693746011384 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 693746011385 trmE is a tRNA modification GTPase; Region: trmE; cd04164 693746011386 G1 box; other site 693746011387 GTP/Mg2+ binding site [chemical binding]; other site 693746011388 Switch I region; other site 693746011389 G2 box; other site 693746011390 Switch II region; other site 693746011391 G3 box; other site 693746011392 G4 box; other site 693746011393 G5 box; other site 693746011394 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 693746011395 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 693746011396 EDD domain protein, DegV family; Region: DegV; TIGR00762 693746011397 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 693746011398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746011399 S-adenosylmethionine binding site [chemical binding]; other site 693746011400 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 693746011401 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 693746011402 Subtilase family; Region: Peptidase_S8; pfam00082 693746011403 active site 693746011404 catalytic triad [active] 693746011405 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 693746011406 active site 693746011407 catalytic triad [active] 693746011408 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 693746011409 active site 693746011410 catalytic triad [active] 693746011411 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 693746011412 active site 693746011413 catalytic triad [active] 693746011414 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 693746011415 ParB-like nuclease domain; Region: ParBc; pfam02195 693746011416 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 693746011417 VanW like protein; Region: VanW; pfam04294 693746011418 G5 domain; Region: G5; pfam07501 693746011419 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 693746011420 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 693746011421 Predicted transcriptional regulator [Transcription]; Region: COG2378 693746011422 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 693746011423 putative DNA binding site [nucleotide binding]; other site 693746011424 putative Zn2+ binding site [ion binding]; other site 693746011425 WYL domain; Region: WYL; pfam13280 693746011426 DNA replication protein DnaC; Validated; Region: PRK06835 693746011427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 693746011428 Walker A motif; other site 693746011429 ATP binding site [chemical binding]; other site 693746011430 Walker B motif; other site 693746011431 arginine finger; other site 693746011432 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 693746011433 Cell division protein ZapA; Region: ZapA; cl01146 693746011434 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 693746011435 Collagenase; Region: DUF3656; pfam12392 693746011436 Peptidase family U32; Region: Peptidase_U32; cl03113 693746011437 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 693746011438 trimer interface [polypeptide binding]; other site 693746011439 active site 693746011440 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 693746011441 active site 693746011442 dimer interface [polypeptide binding]; other site 693746011443 rod shape-determining protein MreC; Provisional; Region: PRK13922 693746011444 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 693746011445 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 693746011446 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 693746011447 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 693746011448 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 693746011449 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 693746011450 active site 693746011451 homodimer interface [polypeptide binding]; other site 693746011452 catalytic site [active] 693746011453 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 693746011454 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 693746011455 P-loop; other site 693746011456 Magnesium ion binding site [ion binding]; other site 693746011457 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 693746011458 ParB-like nuclease domain; Region: ParB; smart00470 693746011459 KorB domain; Region: KorB; pfam08535 693746011460 Protein of unknown function (DUF4527); Region: DUF4527; pfam15030 693746011461 seryl-tRNA synthetase; Provisional; Region: PRK05431 693746011462 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 693746011463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 693746011464 motif 1; other site 693746011465 dimer interface [polypeptide binding]; other site 693746011466 active site 693746011467 motif 2; other site 693746011468 motif 3; other site 693746011469 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 693746011470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 693746011471 Methyltransferase domain; Region: Methyltransf_31; pfam13847 693746011472 S-adenosylmethionine binding site [chemical binding]; other site 693746011473 septum site-determining protein MinD; Region: minD_bact; TIGR01968 693746011474 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 693746011475 P-loop; other site 693746011476 ADP binding residues [chemical binding]; other site 693746011477 Switch I; other site 693746011478 Switch II; other site 693746011479 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 693746011480 substrate binding site [chemical binding]; other site 693746011481 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 693746011482 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 693746011483 dimer interface [polypeptide binding]; other site 693746011484 motif 1; other site 693746011485 active site 693746011486 motif 2; other site 693746011487 motif 3; other site 693746011488 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 693746011489 anticodon binding site; other site 693746011490 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 693746011491 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 693746011492 dimer interface [polypeptide binding]; other site 693746011493 anticodon binding site; other site 693746011494 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 693746011495 homodimer interface [polypeptide binding]; other site 693746011496 motif 1; other site 693746011497 active site 693746011498 motif 2; other site 693746011499 motif 3; other site 693746011500 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 693746011501 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 693746011502 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 693746011503 Sulfatase; Region: Sulfatase; cl19157 693746011504 glycyl-tRNA synthetase; Provisional; Region: PRK04173 693746011505 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 693746011506 dimer interface [polypeptide binding]; other site 693746011507 motif 1; other site 693746011508 active site 693746011509 motif 2; other site 693746011510 motif 3; other site 693746011511 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 693746011512 anticodon binding site; other site 693746011513 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 693746011514 Jag N-terminus; Region: Jag_N; pfam14804 693746011515 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 693746011516 G-X-X-G motif; other site 693746011517 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 693746011518 RxxxH motif; other site 693746011519 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 693746011520 Haemolytic domain; Region: Haemolytic; pfam01809 693746011521 Ribonuclease P; Region: Ribonuclease_P; cl00457 693746011522 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399