-- dump date 20140619_224440 -- class Genbank::misc_feature -- table misc_feature_note -- id note 357244000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 357244000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357244000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244000004 Walker A motif; other site 357244000005 ATP binding site [chemical binding]; other site 357244000006 Walker B motif; other site 357244000007 arginine finger; other site 357244000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 357244000009 DnaA box-binding interface [nucleotide binding]; other site 357244000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 357244000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 357244000012 putative DNA binding surface [nucleotide binding]; other site 357244000013 dimer interface [polypeptide binding]; other site 357244000014 beta-clamp/clamp loader binding surface; other site 357244000015 beta-clamp/translesion DNA polymerase binding surface; other site 357244000016 VirB8 protein; Region: VirB8; pfam04335 357244000017 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 357244000018 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 357244000019 type IV secretion system ATPase VirB11; Provisional; Region: PRK13900 357244000020 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244000021 ATP binding site [chemical binding]; other site 357244000022 Walker B motif; other site 357244000023 type IV secretion system component VirD4; Provisional; Region: PRK13897 357244000024 The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126 357244000025 Walker A motif; other site 357244000026 ATP binding site [chemical binding]; other site 357244000027 Walker B motif; other site 357244000028 transposase and inactivated derivative 357244000029 replicative DNA helicase 357244000030 RNA-directed DNA polymerase (Reverse transcriptase) 357244000031 deoxyribodipyrimidine photo-lyase 357244000032 transposase and inactivated derivative 357244000033 deoxyribodipyrimidine photo-lyase 357244000034 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 357244000035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357244000036 Predicted permeases [General function prediction only]; Region: COG0679 357244000037 translocation protein TolB; Provisional; Region: tolB; PRK05137 357244000038 TolB amino-terminal domain; Region: TolB_N; pfam04052 357244000039 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357244000040 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 357244000041 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357244000042 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357244000043 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357244000044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357244000045 S-adenosylmethionine binding site [chemical binding]; other site 357244000046 conjugative transfer protein 357244000047 conjugative transfer protein 357244000048 tetratricopeptide repeat protein with 5 trp repeats 357244000049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244000050 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244000051 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244000052 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 357244000053 Class I ribonucleotide reductase; Region: RNR_I; cd01679 357244000054 active site 357244000055 dimer interface [polypeptide binding]; other site 357244000056 catalytic residues [active] 357244000057 effector binding site; other site 357244000058 R2 peptide binding site; other site 357244000059 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 357244000060 dimer interface [polypeptide binding]; other site 357244000061 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 357244000062 putative radical transfer pathway; other site 357244000063 diiron center [ion binding]; other site 357244000064 tyrosyl radical; other site 357244000065 conserved hypothetical protein 357244000066 replicative DNA helicase 357244000067 conserved hypothetical protein 357244000068 phage-related integrase 357244000069 submitted as non-pseudo;conjugative transfer protein 357244000070 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244000071 conjugative transfer protein 357244000072 conjugative transfer protein 357244000073 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 357244000074 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 357244000075 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244000076 HD domain; Region: HD_4; pfam13328 357244000077 signal transduction histidine kinase 357244000078 signal transduction histidine kinase 357244000079 copy of ankyrin repeat protein missing the ankyrin repeat domain 357244000080 transposase and inactivated derivative 357244000081 conserved hypothetical protein 357244000082 transposase and inactivated derivative 357244000083 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 357244000084 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357244000085 amidase catalytic site [active] 357244000086 Zn binding residues [ion binding]; other site 357244000087 substrate binding site [chemical binding]; other site 357244000088 transposase and inactivated derivative 357244000089 transposase and inactivated derivative 357244000090 transposase and inactivated derivative 357244000091 transposase and inactivated derivative 357244000092 phage-related integrase 357244000093 transposase and inactivated derivative 357244000094 hypothetical protein 357244000095 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 357244000096 phage-related integrase 357244000097 conserved hypothetical protein 357244000098 RNA-directed DNA polymerase (Reverse transcriptase) 357244000099 transposase and inactivated derivative 357244000100 phage-related integrase 357244000101 submitted as non-pseudo;conjugative transfer protein 357244000102 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244000103 conjugative transfer protein 357244000104 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244000105 conjugative transfer protein 357244000106 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000107 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000108 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000109 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244000110 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244000111 conserved hypothetical protein 357244000112 transposase and inactivated derivative 357244000113 conjugative pilus assembly protein 357244000114 conjugative pilus assembly protein 357244000115 conjugative transfer protein 357244000116 conjugative transfer protein 357244000117 transposase and inactivated derivative 357244000118 conjugative transfer protein 357244000119 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244000120 conjugative transfer protein 357244000121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244000122 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244000123 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244000124 RNA-directed DNA polymerase (Reverse transcriptase) 357244000125 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000126 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244000127 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000128 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000129 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000130 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000131 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000132 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000133 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000134 transposase and inactivated derivative 357244000135 conjugative transfer protein 357244000136 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244000137 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244000138 HD domain; Region: HD_4; pfam13328 357244000139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244000140 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244000141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244000142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244000143 ATP binding site [chemical binding]; other site 357244000144 Mg2+ binding site [ion binding]; other site 357244000145 G-X-G motif; other site 357244000146 submitted as non-pseudo;site-specific DNA adenine methylase 357244000147 spoT-like ppGpp hydrolase 357244000148 replicative DNA helicase 357244000149 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357244000150 conserved hypothetical protein 357244000151 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244000152 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000153 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000154 RNA-directed DNA polymerase (Reverse transcriptase) 357244000155 transposase and inactivated derivative 357244000156 transposase and inactivated derivative 357244000157 Autotransporter beta-domain; Region: Autotransporter; pfam03797 357244000158 transposase and inactivated derivative 357244000159 RNA-directed DNA polymerase (Reverse transcriptase) 357244000160 transposase and inactivated derivative 357244000161 TPR repeat; Region: TPR_11; pfam13414 357244000162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244000163 binding surface 357244000164 TPR motif; other site 357244000165 transposase and inactivated derivative 357244000166 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 357244000167 conjugative pilus assembly protein 357244000168 conjugative pilus assembly protein 357244000169 conjugative transfer protein 357244000170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244000171 TPR motif; other site 357244000172 TPR repeat; Region: TPR_11; pfam13414 357244000173 binding surface 357244000174 TPR repeat; Region: TPR_11; pfam13414 357244000175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244000176 binding surface 357244000177 TPR motif; other site 357244000178 TPR repeat; Region: TPR_11; pfam13414 357244000179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244000180 binding surface 357244000181 TPR motif; other site 357244000182 F sex factor protein N terminal; Region: TraD_N; pfam12615 357244000183 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244000184 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244000185 Walker A motif; other site 357244000186 ATP binding site [chemical binding]; other site 357244000187 Walker B motif; other site 357244000188 transposase and inactivated derivative 357244000189 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 357244000190 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 357244000191 trimer interface [polypeptide binding]; other site 357244000192 active site 357244000193 substrate binding site [chemical binding]; other site 357244000194 CoA binding site [chemical binding]; other site 357244000195 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 357244000196 transposase and inactivated derivative 357244000197 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244000198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244000199 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244000200 transposase and inactivated derivative 357244000201 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 357244000202 submitted as non-pseudo;hypothetical protein 357244000203 transposase and inactivated derivative 357244000204 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244000205 signal transduction histidine kinase 357244000206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244000207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244000208 ATP binding site [chemical binding]; other site 357244000209 Mg2+ binding site [ion binding]; other site 357244000210 G-X-G motif; other site 357244000211 transposase and inactivated derivative 357244000212 tetratricopeptide repeat protein with 8 trp repeats 357244000213 conjugative transfer protein 357244000214 conjugative transfer protein 357244000215 transposase and inactivated derivative 357244000216 conjugative transfer protein 357244000217 transposase and inactivated derivative 357244000218 SurA N-terminal domain; Region: SurA_N_3; cl07813 357244000219 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 357244000220 triosephosphate isomerase; Provisional; Region: PRK14565 357244000221 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 357244000222 substrate binding site [chemical binding]; other site 357244000223 dimer interface [polypeptide binding]; other site 357244000224 catalytic triad [active] 357244000225 Preprotein translocase SecG subunit; Region: SecG; pfam03840 357244000226 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 357244000227 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357244000228 active site 357244000229 nucleotide binding site [chemical binding]; other site 357244000230 HIGH motif; other site 357244000231 KMSKS motif; other site 357244000232 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 357244000233 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 357244000234 diiron binding motif [ion binding]; other site 357244000235 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 357244000236 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 357244000237 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 357244000238 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 357244000239 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 357244000240 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 357244000241 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 357244000242 CoA binding domain; Region: CoA_binding; pfam02629 357244000243 CoA-ligase; Region: Ligase_CoA; pfam00549 357244000244 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 357244000245 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 357244000246 CoA-ligase; Region: Ligase_CoA; pfam00549 357244000247 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 357244000248 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357244000249 Protein of unknown function (DUF1013); Region: DUF1013; cl11533 357244000250 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 357244000251 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 357244000252 HIGH motif; other site 357244000253 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 357244000254 active site 357244000255 KMSKS motif; other site 357244000256 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 357244000257 tRNA binding surface [nucleotide binding]; other site 357244000258 anticodon binding site; other site 357244000259 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 357244000260 COQ9; Region: COQ9; pfam08511 357244000261 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 357244000262 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; cl01106 357244000263 metabolite-proton symporter; Region: 2A0106; TIGR00883 357244000264 replicative DNA helicase 357244000265 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 357244000266 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 357244000267 RNase E interface [polypeptide binding]; other site 357244000268 trimer interface [polypeptide binding]; other site 357244000269 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 357244000270 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 357244000271 RNase E interface [polypeptide binding]; other site 357244000272 trimer interface [polypeptide binding]; other site 357244000273 active site 357244000274 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 357244000275 putative nucleic acid binding region [nucleotide binding]; other site 357244000276 G-X-X-G motif; other site 357244000277 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 357244000278 RNA binding site [nucleotide binding]; other site 357244000279 domain interface; other site 357244000280 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 357244000281 16S/18S rRNA binding site [nucleotide binding]; other site 357244000282 S13e-L30e interaction site [polypeptide binding]; other site 357244000283 25S rRNA binding site [nucleotide binding]; other site 357244000284 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 357244000285 RNA binding site [nucleotide binding]; other site 357244000286 phage-related integrase 357244000287 transposase and inactivated derivative 357244000288 transposase and inactivated derivative 357244000289 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357244000290 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357244000291 non-specific DNA binding site [nucleotide binding]; other site 357244000292 salt bridge; other site 357244000293 sequence-specific DNA binding site [nucleotide binding]; other site 357244000294 transposase and inactivated derivative 357244000295 transposase and inactivated derivative 357244000296 transposase and inactivated derivative 357244000297 ankyrin repeat protein with 4 ankyrin repeats 357244000298 replicative DNA helicase 357244000299 conserved hypothetical protein 357244000300 transposase and inactivated derivative 357244000301 transposase and inactivated derivative 357244000302 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 357244000303 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 357244000304 active site 357244000305 HIGH motif; other site 357244000306 dimer interface [polypeptide binding]; other site 357244000307 KMSKS motif; other site 357244000308 conserved hypothetical protein 357244000309 conjugative transfer protein 357244000310 transposase and inactivated derivative 357244000311 transposase and inactivated derivative 357244000312 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 357244000313 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 357244000314 tandem repeat interface [polypeptide binding]; other site 357244000315 oligomer interface [polypeptide binding]; other site 357244000316 active site residues [active] 357244000317 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 357244000318 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357244000319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357244000320 FeS/SAM binding site; other site 357244000321 TRAM domain; Region: TRAM; pfam01938 357244000322 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 357244000323 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 357244000324 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 357244000325 transposase and inactivated derivative 357244000326 transposase and inactivated derivative 357244000327 transposase and inactivated derivative 357244000328 conserved hypothetical protein 357244000329 conserved hypothetical protein 357244000330 conjugative transfer protein 357244000331 phage-related integrase 357244000332 Uncharacterized conserved protein [Function unknown]; Region: COG2835 357244000333 50S ribosomal protein L31; Provisional; Region: PRK01397 357244000334 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 357244000335 EamA-like transporter family; Region: EamA; pfam00892 357244000336 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 357244000337 EamA-like transporter family; Region: EamA; cl17759 357244000338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244000339 putative substrate translocation pore; other site 357244000340 Beta-lactamase; Region: Beta-lactamase; pfam00144 357244000341 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357244000342 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 357244000343 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 357244000344 dimer interface [polypeptide binding]; other site 357244000345 anticodon binding site; other site 357244000346 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 357244000347 homodimer interface [polypeptide binding]; other site 357244000348 motif 1; other site 357244000349 active site 357244000350 motif 2; other site 357244000351 GAD domain; Region: GAD; pfam02938 357244000352 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357244000353 active site 357244000354 motif 3; other site 357244000355 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 357244000356 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 357244000357 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 357244000358 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 357244000359 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 357244000360 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 357244000361 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 357244000362 cleft; other site 357244000363 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 357244000364 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 357244000365 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 357244000366 DNA binding site [nucleotide binding] 357244000367 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 357244000368 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 357244000369 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357244000370 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 357244000371 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 357244000372 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 357244000373 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 357244000374 RPB1 interaction site [polypeptide binding]; other site 357244000375 RNA polymerase Rpb2, domain 7; Region: RNA_pol_Rpb2_7; pfam04560 357244000376 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 357244000377 core dimer interface [polypeptide binding]; other site 357244000378 peripheral dimer interface [polypeptide binding]; other site 357244000379 L10 interface [polypeptide binding]; other site 357244000380 L11 interface [polypeptide binding]; other site 357244000381 putative EF-Tu interaction site [polypeptide binding]; other site 357244000382 putative EF-G interaction site [polypeptide binding]; other site 357244000383 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 357244000384 23S rRNA interface [nucleotide binding]; other site 357244000385 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 357244000386 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 357244000387 mRNA/rRNA interface [nucleotide binding]; other site 357244000388 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 357244000389 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 357244000390 23S rRNA interface [nucleotide binding]; other site 357244000391 L7/L12 interface [polypeptide binding]; other site 357244000392 putative thiostrepton binding site; other site 357244000393 L25 interface [polypeptide binding]; other site 357244000394 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 357244000395 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 357244000396 putative homodimer interface [polypeptide binding]; other site 357244000397 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 357244000398 heterodimer interface [polypeptide binding]; other site 357244000399 homodimer interface [polypeptide binding]; other site 357244000400 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 357244000401 elongation factor Tu; Reviewed; Region: PRK00049 357244000402 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357244000403 G1 box; other site 357244000404 GEF interaction site [polypeptide binding]; other site 357244000405 GTP/Mg2+ binding site [chemical binding]; other site 357244000406 Switch I region; other site 357244000407 G2 box; other site 357244000408 G3 box; other site 357244000409 Switch II region; other site 357244000410 G4 box; other site 357244000411 G5 box; other site 357244000412 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357244000413 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357244000414 Antibiotic Binding Site [chemical binding]; other site 357244000415 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357244000416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357244000417 putative acyl-acceptor binding pocket; other site 357244000418 recombination protein RecR; Reviewed; Region: recR; PRK00076 357244000419 RecR protein; Region: RecR; pfam02132 357244000420 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 357244000421 putative active site [active] 357244000422 putative metal-binding site [ion binding]; other site 357244000423 tetramer interface [polypeptide binding]; other site 357244000424 intracellular septation protein A; Reviewed; Region: PRK00259 357244000425 Iron permease FTR1 family; Region: FTR1; cl00475 357244000426 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 357244000427 submitted as non-pseudo;conserved hypothetical protein 357244000428 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357244000429 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357244000430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244000431 Walker A/P-loop; other site 357244000432 ATP binding site [chemical binding]; other site 357244000433 Q-loop/lid; other site 357244000434 ABC transporter signature motif; other site 357244000435 Walker B; other site 357244000436 D-loop; other site 357244000437 H-loop/switch region; other site 357244000438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357244000439 dimer interface [polypeptide binding]; other site 357244000440 conserved gate region; other site 357244000441 putative PBP binding loops; other site 357244000442 ABC-ATPase subunit interface; other site 357244000443 transposase and inactivated derivative 357244000444 transposase and inactivated derivative 357244000445 tetratricopeptide repeat protein with 2 trp repeats 357244000446 conjugative transfer protein 357244000447 conjugative pilus assembly protein 357244000448 conjugative pilus assembly protein 357244000449 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244000450 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244000451 conjugative transfer protein 357244000452 ankyrin repeat protein with 5 ankyrin repeats 357244000453 conjugative transfer protein 357244000454 conjugative transfer protein 357244000455 spoT-like ppGpp hydrolase 357244000456 transposase and inactivated derivative 357244000457 spoT-like ppGpp hydrolase 357244000458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244000459 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244000460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244000461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244000462 ATP binding site [chemical binding]; other site 357244000463 Mg2+ binding site [ion binding]; other site 357244000464 G-X-G motif; other site 357244000465 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244000466 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000467 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000468 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000469 conserved hypothetical protein 357244000470 conjugative pilus assembly protein 357244000471 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 357244000472 rRNA binding site [nucleotide binding]; other site 357244000473 predicted 30S ribosome binding site; other site 357244000474 Maf-like protein; Region: Maf; pfam02545 357244000475 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 357244000476 active site 357244000477 dimer interface [polypeptide binding]; other site 357244000478 hypothetical protein; Validated; Region: PRK00110 357244000479 DNA gyrase subunit A; Validated; Region: PRK05560 357244000480 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 357244000481 CAP-like domain; other site 357244000482 active site 357244000483 primary dimer interface [polypeptide binding]; other site 357244000484 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357244000485 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357244000486 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357244000487 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357244000488 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357244000489 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357244000490 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 357244000491 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 357244000492 dimer interface [polypeptide binding]; other site 357244000493 active site 357244000494 glycine-pyridoxal phosphate binding site [chemical binding]; other site 357244000495 folate binding site [chemical binding]; other site 357244000496 Protein of unknown function; Region: DUF3971; pfam13116 357244000497 transposase and inactivated derivative 357244000498 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 357244000499 RNA-directed DNA polymerase (Reverse transcriptase) 357244000500 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 357244000501 Cytochrome c; Region: Cytochrom_C; cl11414 357244000502 ribonuclease PH; Reviewed; Region: rph; PRK00173 357244000503 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 357244000504 oligomer interface [polypeptide binding]; other site 357244000505 RNA binding site [nucleotide binding]; other site 357244000506 GrpE; Region: GrpE; pfam01025 357244000507 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 357244000508 dimer interface [polypeptide binding]; other site 357244000509 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 357244000510 transposase and inactivated derivative 357244000511 transposase and inactivated derivative 357244000512 transposase and inactivated derivative 357244000513 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 357244000514 catalytic site [active] 357244000515 putative active site [active] 357244000516 putative substrate binding site [chemical binding]; other site 357244000517 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 357244000518 Septum formation initiator; Region: DivIC; pfam04977 357244000519 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 357244000520 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 357244000521 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 357244000522 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 357244000523 catalytic residue [active] 357244000524 putative FPP diphosphate binding site; other site 357244000525 putative FPP binding hydrophobic cleft; other site 357244000526 dimer interface [polypeptide binding]; other site 357244000527 putative IPP diphosphate binding site; other site 357244000528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357244000529 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357244000530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357244000531 transposase and inactivated derivative 357244000532 transposase and inactivated derivative 357244000533 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 357244000534 PHP domain; Region: PHP; pfam02811 357244000535 putative active site [active] 357244000536 putative PHP Thumb interface [polypeptide binding]; other site 357244000537 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 357244000538 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 357244000539 generic binding surface II; other site 357244000540 generic binding surface I; other site 357244000541 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 357244000542 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357244000543 active site 357244000544 HIGH motif; other site 357244000545 nucleotide binding site [chemical binding]; other site 357244000546 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357244000547 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357244000548 active site 357244000549 KMSKS motif; other site 357244000550 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 357244000551 tRNA binding surface [nucleotide binding]; other site 357244000552 anticodon binding site; other site 357244000553 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12847 357244000554 UbiA prenyltransferase family; Region: UbiA; pfam01040 357244000555 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 357244000556 dimer interface [polypeptide binding]; other site 357244000557 catalytic triad [active] 357244000558 RNA-directed DNA polymerase (Reverse transcriptase) 357244000559 bacterioferritin comigratory like-protein 357244000560 phage-related integrase 357244000561 transposase and inactivated derivative 357244000562 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 357244000563 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357244000564 RDD family; Region: RDD; pfam06271 357244000565 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 357244000566 transposase and inactivated derivative 357244000567 conjugative transfer protein 357244000568 transposase and inactivated derivative 357244000569 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 357244000570 TPR repeat; Region: TPR_11; pfam13414 357244000571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244000572 binding surface 357244000573 TPR motif; other site 357244000574 transposase and inactivated derivative 357244000575 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 357244000576 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357244000577 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357244000578 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 357244000579 transposase and inactivated derivative 357244000580 spoT-like ppGpp hydrolase 357244000581 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 357244000582 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 357244000583 RNA-directed DNA polymerase (Reverse transcriptase) 357244000584 hypothetical protein 357244000585 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000586 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244000587 transposase and inactivated derivative 357244000588 transposase and inactivated derivative 357244000589 conserved hypothetical protein 357244000590 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 357244000591 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 357244000592 transposase and inactivated derivative 357244000593 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 357244000594 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357244000595 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 357244000596 Walker A/P-loop; other site 357244000597 ATP binding site [chemical binding]; other site 357244000598 Q-loop/lid; other site 357244000599 ABC transporter signature motif; other site 357244000600 Walker B; other site 357244000601 D-loop; other site 357244000602 H-loop/switch region; other site 357244000603 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 357244000604 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357244000605 HlyD family secretion protein; Region: HlyD_3; pfam13437 357244000606 transposase and inactivated derivative 357244000607 transposase and inactivated derivative 357244000608 transposase and inactivated derivative 357244000609 conjugative transfer protein 357244000610 transposase and inactivated derivative 357244000611 TLC ATP/ADP transporter; Region: TLC; pfam03219 357244000612 TLC ATP/ADP transporter; Region: TLC; pfam03219 357244000613 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357244000614 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357244000615 substrate binding pocket [chemical binding]; other site 357244000616 chain length determination region; other site 357244000617 substrate-Mg2+ binding site; other site 357244000618 catalytic residues [active] 357244000619 aspartate-rich region 1; other site 357244000620 active site lid residues [active] 357244000621 aspartate-rich region 2; other site 357244000622 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 357244000623 conjugative transfer protein 357244000624 conjugative transfer protein 357244000625 tetratricopeptide repeat protein with 6 trp repeats 357244000626 conjugative transfer protein 357244000627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244000628 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244000629 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244000630 transposase and inactivated derivative 357244000631 transposase and inactivated derivative 357244000632 transposase and inactivated derivative 357244000633 conjugative transfer protein 357244000634 ankyrin repeat protein with 1 ankyrin repeats 357244000635 conjugative transfer protein 357244000636 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 357244000637 response regulator PleD; Reviewed; Region: pleD; PRK09581 357244000638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357244000639 active site 357244000640 phosphorylation site [posttranslational modification] 357244000641 intermolecular recognition site; other site 357244000642 dimerization interface [polypeptide binding]; other site 357244000643 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357244000644 metal binding site [ion binding]; metal-binding site 357244000645 active site 357244000646 I-site; other site 357244000647 Flavoprotein; Region: Flavoprotein; pfam02441 357244000648 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 357244000649 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357244000650 Transporter associated domain; Region: CorC_HlyC; smart01091 357244000651 metal-binding heat shock protein; Provisional; Region: PRK00016 357244000652 transposase and inactivated derivative 357244000653 tetratricopeptide repeat protein with 1 trp repeats 357244000654 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 357244000655 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 357244000656 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357244000657 Protein of unknown function (DUF2660); Region: DUF2660; pfam10859 357244000658 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 357244000659 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 357244000660 VirB7 interaction site; other site 357244000661 VirB8 protein; Region: VirB8; cl01500 357244000662 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 357244000663 Competence-damaged protein; Region: CinA; pfam02464 357244000664 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 357244000665 tetramer interfaces [polypeptide binding]; other site 357244000666 binuclear metal-binding site [ion binding]; other site 357244000667 transposase and inactivated derivative 357244000668 phage-related integrase 357244000669 conjugative transfer protein 357244000670 transposase and inactivated derivative 357244000671 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357244000672 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357244000673 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 357244000674 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 357244000675 substrate-cofactor binding pocket; other site 357244000676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357244000677 catalytic residue [active] 357244000678 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 357244000679 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357244000680 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 357244000681 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 357244000682 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 357244000683 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 357244000684 alphaNTD homodimer interface [polypeptide binding]; other site 357244000685 alphaNTD - beta interaction site [polypeptide binding]; other site 357244000686 alphaNTD - beta' interaction site [polypeptide binding]; other site 357244000687 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 357244000688 30S ribosomal protein S11; Validated; Region: PRK05309 357244000689 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 357244000690 30S ribosomal protein S13; Region: bact_S13; TIGR03631 357244000691 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 357244000692 adenylate kinase; Region: adk; TIGR01351 357244000693 AMP-binding site [chemical binding]; other site 357244000694 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 357244000695 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 357244000696 SecY translocase; Region: SecY; pfam00344 357244000697 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 357244000698 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 357244000699 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 357244000700 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 357244000701 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 357244000702 5S rRNA interface [nucleotide binding]; other site 357244000703 23S rRNA interface [nucleotide binding]; other site 357244000704 L5 interface [polypeptide binding]; other site 357244000705 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 357244000706 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357244000707 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357244000708 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 357244000709 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 357244000710 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 357244000711 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 357244000712 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 357244000713 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 357244000714 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 357244000715 RNA binding site [nucleotide binding]; other site 357244000716 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 357244000717 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 357244000718 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 357244000719 23S rRNA interface [nucleotide binding]; other site 357244000720 5S rRNA interface [nucleotide binding]; other site 357244000721 putative antibiotic binding site [chemical binding]; other site 357244000722 L25 interface [polypeptide binding]; other site 357244000723 L27 interface [polypeptide binding]; other site 357244000724 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 357244000725 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 357244000726 G-X-X-G motif; other site 357244000727 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 357244000728 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 357244000729 putative translocon binding site; other site 357244000730 protein-rRNA interface [nucleotide binding]; other site 357244000731 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 357244000732 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 357244000733 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 357244000734 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 357244000735 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 357244000736 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 357244000737 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 357244000738 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 357244000739 elongation factor Tu; Reviewed; Region: PRK00049 357244000740 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357244000741 G1 box; other site 357244000742 GEF interaction site [polypeptide binding]; other site 357244000743 GTP/Mg2+ binding site [chemical binding]; other site 357244000744 Switch I region; other site 357244000745 G2 box; other site 357244000746 G3 box; other site 357244000747 Switch II region; other site 357244000748 G4 box; other site 357244000749 G5 box; other site 357244000750 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357244000751 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357244000752 Antibiotic Binding Site [chemical binding]; other site 357244000753 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 357244000754 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 357244000755 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357244000756 recombinase A; Provisional; Region: recA; PRK09354 357244000757 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 357244000758 hexamer interface [polypeptide binding]; other site 357244000759 Walker A motif; other site 357244000760 ATP binding site [chemical binding]; other site 357244000761 Walker B motif; other site 357244000762 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357244000763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357244000764 NAD(P) binding site [chemical binding]; other site 357244000765 active site 357244000766 acyl carrier protein; Provisional; Region: acpP; PRK00982 357244000767 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357244000768 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 357244000769 dimer interface [polypeptide binding]; other site 357244000770 active site 357244000771 transposase and inactivated derivative 357244000772 transposase and inactivated derivative 357244000773 transposase and inactivated derivative 357244000774 transposase and inactivated derivative 357244000775 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 357244000776 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 357244000777 ATP binding site [chemical binding]; other site 357244000778 active site 357244000779 substrate binding site [chemical binding]; other site 357244000780 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 357244000781 putative coenzyme Q binding site [chemical binding]; other site 357244000782 lipoyl synthase; Provisional; Region: PRK05481 357244000783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357244000784 FeS/SAM binding site; other site 357244000785 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 357244000786 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 357244000787 tandem repeat interface [polypeptide binding]; other site 357244000788 oligomer interface [polypeptide binding]; other site 357244000789 active site residues [active] 357244000790 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 357244000791 SmpB-tmRNA interface; other site 357244000792 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 357244000793 dihydrodipicolinate synthase; Region: dapA; TIGR00674 357244000794 dimer interface [polypeptide binding]; other site 357244000795 active site 357244000796 catalytic residue [active] 357244000797 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357244000798 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 357244000799 homodimer interface [polypeptide binding]; other site 357244000800 substrate-cofactor binding pocket; other site 357244000801 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357244000802 catalytic residue [active] 357244000803 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 357244000804 AAA domain; Region: AAA_30; pfam13604 357244000805 Family description; Region: UvrD_C_2; pfam13538 357244000806 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 357244000807 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 357244000808 Protein of unknown function (DUF2497); Region: DUF2497; pfam10691 357244000809 Outer membrane efflux protein; Region: OEP; pfam02321 357244000810 Outer membrane efflux protein; Region: OEP; pfam02321 357244000811 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 357244000812 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244000813 active site 357244000814 DNA binding site [nucleotide binding] 357244000815 Int/Topo IB signature motif; other site 357244000816 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 357244000817 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357244000818 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 357244000819 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 357244000820 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 357244000821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357244000822 S-adenosylmethionine binding site [chemical binding]; other site 357244000823 DNA repair protein RadA; Provisional; Region: PRK11823 357244000824 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244000825 Walker A motif; other site 357244000826 ATP binding site [chemical binding]; other site 357244000827 Walker B motif; other site 357244000828 EamA-like transporter family; Region: EamA; pfam00892 357244000829 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357244000830 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 357244000831 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 357244000832 conserved hypothetical protein 357244000833 transposase and inactivated derivative 357244000834 transposase and inactivated derivative 357244000835 conserved hypothetical protein 357244000836 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244000837 active site 357244000838 Int/Topo IB signature motif; other site 357244000839 DNA binding site [nucleotide binding] 357244000840 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244000841 conjugative transfer protein 357244000842 ankyrin repeat protein with 3 ankyrin repeats 357244000843 conjugative transfer protein 357244000844 transposase and inactivated derivative 357244000845 conserved hypothetical protein 357244000846 transposase and inactivated derivative 357244000847 RNA-directed DNA polymerase (Reverse transcriptase) 357244000848 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 357244000849 transposase and inactivated derivative 357244000850 transposase and inactivated derivative 357244000851 transposase and inactivated derivative 357244000852 transposase and inactivated derivative 357244000853 transposase and inactivated derivative 357244000854 RNA-directed DNA polymerase (Reverse transcriptase) 357244000855 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357244000856 catalytic residues [active] 357244000857 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 357244000858 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357244000859 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357244000860 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357244000861 Surface antigen; Region: Bac_surface_Ag; pfam01103 357244000862 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 357244000863 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 357244000864 active site 357244000865 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357244000866 protein binding site [polypeptide binding]; other site 357244000867 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 357244000868 putative substrate binding region [chemical binding]; other site 357244000869 RmuC family; Region: RmuC; pfam02646 357244000870 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 357244000871 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 357244000872 SurA N-terminal domain; Region: SurA_N_3; cl07813 357244000873 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 357244000874 IHF dimer interface [polypeptide binding]; other site 357244000875 IHF - DNA interface [nucleotide binding]; other site 357244000876 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 357244000877 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357244000878 intersubunit interface [polypeptide binding]; other site 357244000879 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 357244000880 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 357244000881 active site 357244000882 NTP binding site [chemical binding]; other site 357244000883 metal binding triad [ion binding]; metal-binding site 357244000884 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 357244000885 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357244000886 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 357244000887 Part of AAA domain; Region: AAA_19; pfam13245 357244000888 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 357244000889 Family description; Region: UvrD_C_2; pfam13538 357244000890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357244000891 catalytic core [active] 357244000892 dihydrodipicolinate reductase; Provisional; Region: PRK00048 357244000893 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 357244000894 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 357244000895 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357244000896 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357244000897 substrate binding pocket [chemical binding]; other site 357244000898 membrane-bound complex binding site; other site 357244000899 hinge residues; other site 357244000900 conserved hypothetical protein 357244000901 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 357244000902 transposase and inactivated derivative 357244000903 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 357244000904 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 357244000905 transposase and inactivated derivative 357244000906 GTPase Era; Reviewed; Region: era; PRK00089 357244000907 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 357244000908 G1 box; other site 357244000909 GTP/Mg2+ binding site [chemical binding]; other site 357244000910 Switch I region; other site 357244000911 G2 box; other site 357244000912 Switch II region; other site 357244000913 G3 box; other site 357244000914 G4 box; other site 357244000915 G5 box; other site 357244000916 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357244000917 peptide chain release factor 1; Validated; Region: prfA; PRK00591 357244000918 This domain is found in peptide chain release factors; Region: PCRF; smart00937 357244000919 RF-1 domain; Region: RF-1; pfam00472 357244000920 transposase and inactivated derivative 357244000921 conserved hypothetical protein 357244000922 replicative DNA helicase 357244000923 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000924 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000925 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000926 PRANC domain; Region: PRANC; pfam09372 357244000927 RNA-directed DNA polymerase (Reverse transcriptase) 357244000928 RNA-directed DNA polymerase (Reverse transcriptase) 357244000929 transposase and inactivated derivative 357244000930 exopolyphosphatase; Region: exo_poly_only; TIGR03706 357244000931 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 357244000932 transposase and inactivated derivative 357244000933 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 357244000934 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 357244000935 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 357244000936 HIGH motif; other site 357244000937 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357244000938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357244000939 active site 357244000940 KMSKS motif; other site 357244000941 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 357244000942 tRNA binding surface [nucleotide binding]; other site 357244000943 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 357244000944 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 357244000945 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 357244000946 MgtE intracellular N domain; Region: MgtE_N; pfam03448 357244000947 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 357244000948 Divalent cation transporter; Region: MgtE; pfam01769 357244000949 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 357244000950 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 357244000951 active site 357244000952 Zn binding site [ion binding]; other site 357244000953 conjugative pilus assembly protein 357244000954 conserved hypothetical protein 357244000955 replicative DNA helicase 357244000956 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244000957 HD domain; Region: HD_4; pfam13328 357244000958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000959 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000960 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000961 transposase and inactivated derivative 357244000962 signal transduction histidine kinase 357244000963 transposase and inactivated derivative 357244000964 signal transduction histidine kinase 357244000965 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244000966 HD domain; Region: HD_4; pfam13328 357244000967 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 357244000968 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 357244000969 RNA-directed DNA polymerase (Reverse transcriptase) 357244000970 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244000971 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244000972 PRANC domain; Region: PRANC; pfam09372 357244000973 conjugative transfer protein 357244000974 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 357244000975 phage-related integrase 357244000976 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 357244000977 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 357244000978 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357244000979 RNA binding surface [nucleotide binding]; other site 357244000980 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 357244000981 RNA methyltransferase, RsmE family; Region: TIGR00046 357244000982 transposase and inactivated derivative 357244000983 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 357244000984 Permease; Region: Permease; pfam02405 357244000985 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 357244000986 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 357244000987 Walker A/P-loop; other site 357244000988 ATP binding site [chemical binding]; other site 357244000989 Q-loop/lid; other site 357244000990 ABC transporter signature motif; other site 357244000991 Walker B; other site 357244000992 D-loop; other site 357244000993 H-loop/switch region; other site 357244000994 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 357244000995 DHH family; Region: DHH; pfam01368 357244000996 DHHA1 domain; Region: DHHA1; pfam02272 357244000997 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 357244000998 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 357244000999 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357244001000 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 357244001001 Enoylreductase; Region: PKS_ER; smart00829 357244001002 NADP binding site [chemical binding]; other site 357244001003 dimer interface [polypeptide binding]; other site 357244001004 phage-related integrase 357244001005 transposase and inactivated derivative 357244001006 transposase and inactivated derivative 357244001007 transposase and inactivated derivative 357244001008 conserved hypothetical protein 357244001009 transposase and inactivated derivative 357244001010 TraE protein; Region: TraE; cl05060 357244001011 conjugative transfer protein 357244001012 transposase and inactivated derivative 357244001013 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 357244001014 Na binding site [ion binding]; other site 357244001015 muropeptide transporter; Reviewed; Region: ampG; PRK11902 357244001016 muropeptide transporter; Validated; Region: ampG; cl17669 357244001017 phage-related integrase 357244001018 conjugative transfer protein 357244001019 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244001020 spoT-like ppGpp hydrolase 357244001021 transposase and inactivated derivative 357244001022 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 357244001023 TPR repeat; Region: TPR_11; pfam13414 357244001024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001025 binding surface 357244001026 TPR motif; other site 357244001027 TPR repeat; Region: TPR_11; pfam13414 357244001028 TPR repeat; Region: TPR_11; pfam13414 357244001029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001030 binding surface 357244001031 TPR motif; other site 357244001032 TPR repeat; Region: TPR_11; pfam13414 357244001033 conjugative transfer protein 357244001034 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001035 conjugative transfer protein 357244001036 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244001037 conjugative transfer protein 357244001038 phage-related integrase 357244001039 transposase and inactivated derivative 357244001040 RNA-directed DNA polymerase (Reverse transcriptase) 357244001041 transposase and inactivated derivative 357244001042 transposase and inactivated derivative 357244001043 conserved hypothetical protein 357244001044 transposase and inactivated derivative 357244001045 transposase and inactivated derivative 357244001046 transposase and inactivated derivative 357244001047 phage-related integrase 357244001048 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357244001049 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 357244001050 catalytic triad [active] 357244001051 transposase and inactivated derivative 357244001052 conserved hypothetical protein 357244001053 TLC ATP/ADP transporter; Region: TLC; pfam03219 357244001054 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 357244001055 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 357244001056 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 357244001057 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 357244001058 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 357244001059 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 357244001060 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357244001061 DNA binding site [nucleotide binding] 357244001062 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357244001063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357244001064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244001065 Walker A/P-loop; other site 357244001066 ATP binding site [chemical binding]; other site 357244001067 Q-loop/lid; other site 357244001068 ABC transporter signature motif; other site 357244001069 Walker B; other site 357244001070 D-loop; other site 357244001071 H-loop/switch region; other site 357244001072 transposase and inactivated derivative 357244001073 trigger factor; Region: tig; TIGR00115 357244001074 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 357244001075 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 357244001076 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 357244001077 metal binding site [ion binding]; metal-binding site 357244001078 dimer interface [polypeptide binding]; other site 357244001079 heat shock protein 90; Provisional; Region: PRK05218 357244001080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001081 ATP binding site [chemical binding]; other site 357244001082 Mg2+ binding site [ion binding]; other site 357244001083 G-X-G motif; other site 357244001084 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 357244001085 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 357244001086 23S rRNA binding site [nucleotide binding]; other site 357244001087 L21 binding site [polypeptide binding]; other site 357244001088 L13 binding site [polypeptide binding]; other site 357244001089 transposase and inactivated derivative 357244001090 transposase and inactivated derivative 357244001091 transposase and inactivated derivative 357244001092 RNA-directed DNA polymerase (Reverse transcriptase) 357244001093 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 357244001094 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 357244001095 RNA-directed DNA polymerase (Reverse transcriptase) 357244001096 transposase and inactivated derivative 357244001097 RNA-directed DNA polymerase (Reverse transcriptase) 357244001098 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 357244001099 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357244001100 Sporulation related domain; Region: SPOR; pfam05036 357244001101 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 357244001102 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 357244001103 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 357244001104 active site 357244001105 HIGH motif; other site 357244001106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357244001107 KMSK motif region; other site 357244001108 tRNA binding surface [nucleotide binding]; other site 357244001109 DALR anticodon binding domain; Region: DALR_1; smart00836 357244001110 anticodon binding site; other site 357244001111 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 357244001112 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 357244001113 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357244001114 HIGH motif; other site 357244001115 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357244001116 active site 357244001117 KMSKS motif; other site 357244001118 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 357244001119 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 357244001120 motif 1; other site 357244001121 active site 357244001122 motif 2; other site 357244001123 motif 3; other site 357244001124 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357244001125 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 357244001126 core domain interface [polypeptide binding]; other site 357244001127 delta subunit interface [polypeptide binding]; other site 357244001128 epsilon subunit interface [polypeptide binding]; other site 357244001129 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 357244001130 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357244001131 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 357244001132 beta subunit interaction interface [polypeptide binding]; other site 357244001133 Walker A motif; other site 357244001134 ATP binding site [chemical binding]; other site 357244001135 Walker B motif; other site 357244001136 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357244001137 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 357244001138 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 357244001139 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 357244001140 trimer interface [polypeptide binding]; other site 357244001141 active site 357244001142 transposase and inactivated derivative 357244001143 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 357244001144 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 357244001145 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 357244001146 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 357244001147 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 357244001148 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357244001149 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 357244001150 active site 357244001151 dimer interface [polypeptide binding]; other site 357244001152 motif 1; other site 357244001153 motif 2; other site 357244001154 motif 3; other site 357244001155 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 357244001156 anticodon binding site; other site 357244001157 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 357244001158 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357244001159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357244001160 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 357244001161 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 357244001162 SEC-C motif; Region: SEC-C; pfam02810 357244001163 transposase and inactivated derivative 357244001164 conjugative transfer protein 357244001165 transposase and inactivated derivative 357244001166 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 357244001167 putative active site [active] 357244001168 Ap4A binding site [chemical binding]; other site 357244001169 nudix motif; other site 357244001170 putative metal binding site [ion binding]; other site 357244001171 conserved hypothetical protein 357244001172 transposase and inactivated derivative 357244001173 RNA-directed DNA polymerase (Reverse transcriptase) 357244001174 conjugative pilus assembly protein 357244001175 transposase and inactivated derivative 357244001176 recombination protein F; Reviewed; Region: recF; PRK00064 357244001177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244001178 Walker A/P-loop; other site 357244001179 ATP binding site [chemical binding]; other site 357244001180 Q-loop/lid; other site 357244001181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244001182 ABC transporter signature motif; other site 357244001183 Walker B; other site 357244001184 D-loop; other site 357244001185 H-loop/switch region; other site 357244001186 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 357244001187 Cell division protein FtsQ; Region: FtsQ; pfam03799 357244001188 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 357244001189 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 357244001190 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357244001191 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 357244001192 FAD binding domain; Region: FAD_binding_4; pfam01565 357244001193 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 357244001194 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 357244001195 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357244001196 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357244001197 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357244001198 Type specific antigen; Region: TSA; pfam03249 357244001199 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 357244001200 motif 1; other site 357244001201 dimer interface [polypeptide binding]; other site 357244001202 active site 357244001203 motif 2; other site 357244001204 motif 3; other site 357244001205 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 357244001206 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 357244001207 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 357244001208 transposase and inactivated derivative 357244001209 transposase and inactivated derivative 357244001210 RNA-directed DNA polymerase (Reverse transcriptase) 357244001211 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 357244001212 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 357244001213 spoT-like ppGpp hydrolase 357244001214 conserved hypothetical protein 357244001215 replicative DNA helicase 357244001216 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001217 HD domain; Region: HD_4; pfam13328 357244001218 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001219 Ankyrin repeat; Region: Ank; pfam00023 357244001220 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001221 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001222 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244001223 signal transduction histidine kinase 357244001224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001226 ATP binding site [chemical binding]; other site 357244001227 Mg2+ binding site [ion binding]; other site 357244001228 G-X-G motif; other site 357244001229 transposase and inactivated derivative 357244001230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 357244001231 ATP binding site [chemical binding]; other site 357244001232 Mg2+ binding site [ion binding]; other site 357244001233 G-X-G motif; other site 357244001234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001236 ATP binding site [chemical binding]; other site 357244001237 Mg2+ binding site [ion binding]; other site 357244001238 G-X-G motif; other site 357244001239 signal transduction histidine kinase 357244001240 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001241 HD domain; Region: HD_4; pfam13328 357244001242 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 357244001243 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 357244001244 transposase and inactivated derivative 357244001245 spoT-like ppGpp hydrolase 357244001246 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244001247 conjugative transfer protein 357244001248 putative transposase; Provisional; Region: PRK09857 357244001249 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244001250 conjugative transfer protein 357244001251 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001252 TPR motif; other site 357244001253 TPR repeat; Region: TPR_11; pfam13414 357244001254 binding surface 357244001255 TPR repeat; Region: TPR_11; pfam13414 357244001256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001257 binding surface 357244001258 TPR motif; other site 357244001259 TPR repeat; Region: TPR_11; pfam13414 357244001260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001261 binding surface 357244001262 TPR motif; other site 357244001263 conjugative transfer protein 357244001264 conjugative pilus assembly protein 357244001265 conjugative pilus assembly protein 357244001266 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244001267 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001268 TraU protein; Region: TraU; pfam06834 357244001269 conjugative transfer protein 357244001270 conserved hypothetical protein 357244001271 conjugative pilus assembly protein 357244001272 conjugative transfer protein 357244001273 phage-related integrase 357244001274 conserved hypothetical protein 357244001275 phage-related integrase 357244001276 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 357244001277 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 357244001278 Walker A motif; other site 357244001279 ATP binding site [chemical binding]; other site 357244001280 Walker B motif; other site 357244001281 DNA binding loops [nucleotide binding] 357244001282 spoT-like ppGpp hydrolase 357244001283 phage-related integrase 357244001284 replicative DNA helicase 357244001285 conserved hypothetical protein 357244001286 RNA-directed DNA polymerase (Reverse transcriptase) 357244001287 conjugative pilus assembly protein 357244001288 bacterioferritin comigratory protein 357244001289 conjugative transfer protein 357244001290 transposase and inactivated derivative 357244001291 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 357244001292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244001293 POT family; Region: PTR2; cl17359 357244001294 fumarate hydratase; Reviewed; Region: fumC; PRK00485 357244001295 Class II fumarases; Region: Fumarase_classII; cd01362 357244001296 active site 357244001297 tetramer interface [polypeptide binding]; other site 357244001298 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 357244001299 transposase and inactivated derivative 357244001300 transposase and inactivated derivative 357244001301 RNA-directed DNA polymerase (Reverse transcriptase) 357244001302 transposase and inactivated derivative 357244001303 conjugative transfer protein 357244001304 conjugative transfer protein 357244001305 conjugative transfer protein 357244001306 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 357244001307 GSH binding site [chemical binding]; other site 357244001308 catalytic residues [active] 357244001309 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 357244001310 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 357244001311 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 357244001312 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 357244001313 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 357244001314 Phage capsid family; Region: Phage_capsid; pfam05065 357244001315 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 357244001316 conserved hypothetical protein 357244001317 transposase and inactivated derivative 357244001318 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 357244001319 transposase and inactivated derivative 357244001320 conjugative transfer protein 357244001321 phage-related integrase 357244001322 transposase and inactivated derivative 357244001323 conjugative transfer protein 357244001324 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244001325 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001326 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001327 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001328 PRANC domain; Region: PRANC; pfam09372 357244001329 conjugative transfer protein 357244001330 transposase and inactivated derivative 357244001331 transposase and inactivated derivative 357244001332 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357244001333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244001334 Walker A/P-loop; other site 357244001335 ATP binding site [chemical binding]; other site 357244001336 Q-loop/lid; other site 357244001337 ABC transporter signature motif; other site 357244001338 Walker B; other site 357244001339 D-loop; other site 357244001340 H-loop/switch region; other site 357244001341 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 357244001342 putative nucleotide binding site [chemical binding]; other site 357244001343 uridine monophosphate binding site [chemical binding]; other site 357244001344 homohexameric interface [polypeptide binding]; other site 357244001345 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 357244001346 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 357244001347 Mg++ binding site [ion binding]; other site 357244001348 putative catalytic motif [active] 357244001349 putative substrate binding site [chemical binding]; other site 357244001350 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357244001351 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 357244001352 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357244001353 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357244001354 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 357244001355 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357244001356 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357244001357 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357244001358 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357244001359 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357244001360 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357244001361 conserved hypothetical protein 357244001362 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 357244001363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357244001364 S-adenosylmethionine binding site [chemical binding]; other site 357244001365 chaperone protein DnaJ; Provisional; Region: PRK10767 357244001366 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357244001367 HSP70 interaction site [polypeptide binding]; other site 357244001368 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 357244001369 substrate binding site [polypeptide binding]; other site 357244001370 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 357244001371 Zn binding sites [ion binding]; other site 357244001372 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 357244001373 dimer interface [polypeptide binding]; other site 357244001374 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 357244001375 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 357244001376 nucleotide binding site [chemical binding]; other site 357244001377 NEF interaction site [polypeptide binding]; other site 357244001378 SBD interface [polypeptide binding]; other site 357244001379 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 357244001380 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 357244001381 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 357244001382 NAD binding site [chemical binding]; other site 357244001383 homotetramer interface [polypeptide binding]; other site 357244001384 homodimer interface [polypeptide binding]; other site 357244001385 substrate binding site [chemical binding]; other site 357244001386 active site 357244001387 RNA-directed DNA polymerase (Reverse transcriptase) 357244001388 transposase and inactivated derivative 357244001389 phage-related integrase 357244001390 submitted as non-pseudo;conjugative transfer protein 357244001391 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244001392 conjugative transfer protein 357244001393 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 357244001394 conjugative transfer protein 357244001395 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001396 conjugative transfer protein 357244001397 conjugative pilus assembly protein 357244001398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001399 binding surface 357244001400 TPR motif; other site 357244001401 TPR repeat; Region: TPR_11; pfam13414 357244001402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001403 binding surface 357244001404 TPR motif; other site 357244001405 TPR repeat; Region: TPR_11; pfam13414 357244001406 TPR repeat; Region: TPR_11; pfam13414 357244001407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001408 binding surface 357244001409 TPR motif; other site 357244001410 TPR repeat; Region: TPR_11; pfam13414 357244001411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244001412 binding surface 357244001413 TPR motif; other site 357244001414 conjugative transfer protein 357244001415 conjugative transfer protein 357244001416 transposase and inactivated derivative 357244001417 conjugative transfer protein 357244001418 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001419 HD domain; Region: HD_4; pfam13328 357244001420 signal transduction histidine kinase 357244001421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001422 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244001423 submitted as non-pseudo;conserved hypothetical protein 357244001424 submitted as non-pseudo;site-specific DNA adenine methylase 357244001425 transposase and inactivated derivative 357244001426 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 357244001427 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 357244001428 gamma subunit interface [polypeptide binding]; other site 357244001429 epsilon subunit interface [polypeptide binding]; other site 357244001430 LBP interface [polypeptide binding]; other site 357244001431 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 357244001432 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357244001433 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 357244001434 alpha subunit interaction interface [polypeptide binding]; other site 357244001435 Walker A motif; other site 357244001436 ATP binding site [chemical binding]; other site 357244001437 Walker B motif; other site 357244001438 inhibitor binding site; inhibition site 357244001439 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357244001440 transposase and inactivated derivative 357244001441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357244001442 This family is most closely related to the GT1 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core; Region: GT1_WavL_like; cd03819 357244001443 putative ADP-binding pocket [chemical binding]; other site 357244001444 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357244001445 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 357244001446 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357244001447 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357244001448 catalytic residue [active] 357244001449 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 357244001450 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357244001451 transposase and inactivated derivative 357244001452 transposase and inactivated derivative 357244001453 transposase and inactivated derivative 357244001454 transposase and inactivated derivative 357244001455 phage-related integrase 357244001456 RNA-directed DNA polymerase (Reverse transcriptase) 357244001457 transposase and inactivated derivative 357244001458 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 357244001459 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357244001460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001461 ATP binding site [chemical binding]; other site 357244001462 Mg2+ binding site [ion binding]; other site 357244001463 G-X-G motif; other site 357244001464 signal transduction histidine kinase 357244001465 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001466 HD domain; Region: HD_4; pfam13328 357244001467 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 357244001468 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 357244001469 RNA-directed DNA polymerase (Reverse transcriptase) 357244001470 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001471 transposase and inactivated derivative 357244001472 transposase and inactivated derivative 357244001473 transposase and inactivated derivative 357244001474 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 357244001475 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 357244001476 active site 357244001477 HIGH motif; other site 357244001478 dimer interface [polypeptide binding]; other site 357244001479 KMSKS motif; other site 357244001480 ankyrin repeat protein with 1 ankyrin repeats 357244001481 RNA-directed DNA polymerase (Reverse transcriptase) 357244001482 transposase and inactivated derivative 357244001483 pyruvate phosphate dikinase; Provisional; Region: PRK09279 357244001484 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 357244001485 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357244001486 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357244001487 transposase and inactivated derivative 357244001488 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 357244001489 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 357244001490 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 357244001491 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 357244001492 F0F1 ATP synthase subunit B'; Validated; Region: PRK06569 357244001493 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 357244001494 transposase and inactivated derivative 357244001495 transposase and inactivated derivative 357244001496 transposase and inactivated derivative 357244001497 transposase and inactivated derivative 357244001498 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 357244001499 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357244001500 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 357244001501 Protein of unknown function (DUF2672); Region: DUF2672; pfam10878 357244001502 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 357244001503 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357244001504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357244001505 ABC transporter; Region: ABC_tran_2; pfam12848 357244001506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357244001507 transposase and inactivated derivative 357244001508 transposase and inactivated derivative 357244001509 signal recognition particle protein; Provisional; Region: PRK10867 357244001510 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 357244001511 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357244001512 Signal peptide binding domain; Region: SRP_SPB; pfam02978 357244001513 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 357244001514 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 357244001515 Guanylate kinase; Region: Guanylate_kin; pfam00625 357244001516 catalytic site [active] 357244001517 G-X2-G-X-G-K; other site 357244001518 120 KDa Rickettsia surface antigen; Region: 120_Rick_ant; pfam12574 357244001519 conserved hypothetical protein 357244001520 replicative DNA helicase 357244001521 spoT-like ppGpp hydrolase 357244001522 phage-related integrase 357244001523 transposase and inactivated derivative 357244001524 transposase and inactivated derivative 357244001525 conjugative transfer protein 357244001526 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244001527 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001528 HD domain; Region: HD_4; pfam13328 357244001529 replicative DNA helicase 357244001530 conserved hypothetical protein 357244001531 transposase and inactivated derivative 357244001532 hypothetical protein; Validated; Region: PRK01415 357244001533 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 357244001534 active site residue [active] 357244001535 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 357244001536 RNA-directed DNA polymerase (Reverse transcriptase) 357244001537 transposase and inactivated derivative 357244001538 conserved hypothetical protein 357244001539 Uncharacterized conserved protein [Function unknown]; Region: COG1565 357244001540 RNA-directed DNA polymerase (Reverse transcriptase) 357244001541 transposase and inactivated derivative 357244001542 submitted as non-pseudo;conjugative transfer protein 357244001543 conserved hypothetical protein 357244001544 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001545 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244001546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001547 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244001548 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001550 ATP binding site [chemical binding]; other site 357244001551 Mg2+ binding site [ion binding]; other site 357244001552 G-X-G motif; other site 357244001553 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001554 HD domain; Region: HD_4; pfam13328 357244001555 conjugative transfer protein 357244001556 conjugative transfer protein 357244001557 transposase and inactivated derivative 357244001558 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244001559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244001560 Walker B motif; other site 357244001561 conjugative transfer protein 357244001562 conjugative pilus assembly protein 357244001563 conjugative pilus assembly protein 357244001564 conjugative transfer protein 357244001565 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001566 conjugative transfer protein 357244001567 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244001568 submitted as non-pseudo;conjugative transfer protein 357244001569 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244001570 active site 357244001571 Int/Topo IB signature motif; other site 357244001572 DNA binding site [nucleotide binding] 357244001573 transposase and inactivated derivative 357244001574 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 357244001575 Na binding site [ion binding]; other site 357244001576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001577 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357244001578 dimer interface [polypeptide binding]; other site 357244001579 phosphorylation site [posttranslational modification] 357244001580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001581 ATP binding site [chemical binding]; other site 357244001582 Mg2+ binding site [ion binding]; other site 357244001583 G-X-G motif; other site 357244001584 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357244001585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357244001586 active site 357244001587 phosphorylation site [posttranslational modification] 357244001588 intermolecular recognition site; other site 357244001589 dimerization interface [polypeptide binding]; other site 357244001590 isocitrate dehydrogenase; Validated; Region: PRK09222 357244001591 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 357244001592 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 357244001593 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 357244001594 domain interfaces; other site 357244001595 active site 357244001596 metabolite-proton symporter; Region: 2A0106; TIGR00883 357244001597 transposase and inactivated derivative 357244001598 transposase and inactivated derivative 357244001599 RNA-directed DNA polymerase (Reverse transcriptase) 357244001600 hypothetical protein 357244001601 This domain is found in various eukaryotic species, particularly in apicomplexans; Region: RAP; smart00952 357244001602 replicative DNA helicase 357244001603 transposase and inactivated derivative 357244001604 ABC-type anion transport system permease component 357244001605 threonine dehydratase; Provisional; Region: PRK06608 357244001606 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 357244001607 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357244001608 catalytic residue [active] 357244001609 Found in ATP-dependent protease La (LON); Region: LON; smart00464 357244001610 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357244001611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244001612 Walker A motif; other site 357244001613 ATP binding site [chemical binding]; other site 357244001614 Walker B motif; other site 357244001615 arginine finger; other site 357244001616 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357244001617 hypothetical protein; Validated; Region: PRK06620 357244001618 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 357244001619 Walker A motif; other site 357244001620 ATP binding site [chemical binding]; other site 357244001621 Walker B motif; other site 357244001622 arginine finger; other site 357244001623 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 357244001624 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 357244001625 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 357244001626 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 357244001627 RNA/DNA hybrid binding site [nucleotide binding]; other site 357244001628 active site 357244001629 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 357244001630 phage-related integrase 357244001631 RNA-directed DNA polymerase (Reverse transcriptase) 357244001632 transposase and inactivated derivative 357244001633 Autotransporter beta-domain; Region: Autotransporter; smart00869 357244001634 transposase and inactivated derivative 357244001635 hypothetical protein 357244001636 transposase and inactivated derivative 357244001637 transposase and inactivated derivative 357244001638 transposase and inactivated derivative 357244001639 transposase and inactivated derivative 357244001640 conserved hypothetical protein 357244001641 transposase and inactivated derivative 357244001642 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244001643 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244001644 Walker B motif; other site 357244001645 conjugative transfer protein 357244001646 conjugative pilus assembly protein 357244001647 conjugative pilus assembly protein 357244001648 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244001649 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001650 conjugative transfer protein 357244001651 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244001652 TraE protein; Region: TraE; cl05060 357244001653 phage-related integrase 357244001654 transposase and inactivated derivative 357244001655 conjugative transfer protein 357244001656 conserved hypothetical protein 357244001657 conjugative transfer protein 357244001658 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244001659 spoT-like ppGpp hydrolase 357244001660 transposase and inactivated derivative 357244001661 signal transduction histidine kinase 357244001662 signal transduction histidine kinase 357244001663 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244001664 site-specific DNA adenine methylase 357244001665 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001666 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001667 conserved hypothetical protein 357244001668 transposase and inactivated derivative 357244001669 conserved hypothetical protein 357244001670 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 357244001671 30S subunit binding site; other site 357244001672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357244001673 dimer interface [polypeptide binding]; other site 357244001674 phosphorylation site [posttranslational modification] 357244001675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001676 ATP binding site [chemical binding]; other site 357244001677 Mg2+ binding site [ion binding]; other site 357244001678 G-X-G motif; other site 357244001679 transposase and inactivated derivative 357244001680 transposase and inactivated derivative 357244001681 submitted as non-pseudo;hypothetical protein 357244001682 replicative DNA helicase; Provisional; Region: PRK09165 357244001683 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 357244001684 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 357244001685 Walker A motif; other site 357244001686 ATP binding site [chemical binding]; other site 357244001687 Walker B motif; other site 357244001688 DNA binding loops [nucleotide binding] 357244001689 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001690 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001691 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001692 PRANC domain; Region: PRANC; pfam09372 357244001693 RNA-directed DNA polymerase (Reverse transcriptase) 357244001694 RNA-directed DNA polymerase (Reverse transcriptase) 357244001695 transposase and inactivated derivative 357244001696 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357244001697 oligomerisation interface [polypeptide binding]; other site 357244001698 mobile loop; other site 357244001699 roof hairpin; other site 357244001700 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 357244001701 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 357244001702 ring oligomerisation interface [polypeptide binding]; other site 357244001703 ATP/Mg binding site [chemical binding]; other site 357244001704 stacking interactions; other site 357244001705 hinge regions; other site 357244001706 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 357244001707 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001708 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357244001709 Zn2+ binding site [ion binding]; other site 357244001710 Mg2+ binding site [ion binding]; other site 357244001711 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357244001712 synthetase active site [active] 357244001713 NTP binding site [chemical binding]; other site 357244001714 metal binding site [ion binding]; metal-binding site 357244001715 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 357244001716 ACT domain; Region: ACT_4; pfam13291 357244001717 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 357244001718 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 357244001719 Cytochrome C biogenesis protein; Region: CcmH; cl01179 357244001720 GTPase CgtA; Reviewed; Region: obgE; PRK12299 357244001721 GTP1/OBG; Region: GTP1_OBG; pfam01018 357244001722 Obg GTPase; Region: Obg; cd01898 357244001723 G1 box; other site 357244001724 GTP/Mg2+ binding site [chemical binding]; other site 357244001725 Switch I region; other site 357244001726 G2 box; other site 357244001727 G3 box; other site 357244001728 Switch II region; other site 357244001729 G4 box; other site 357244001730 G5 box; other site 357244001731 twin arginine translocase protein A; Provisional; Region: tatA; PRK01470 357244001732 conserved hypothetical protein 357244001733 phage-related integrase 357244001734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244001735 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244001736 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244001737 conjugative transfer protein 357244001738 conjugative pilus assembly protein 357244001739 conjugative pilus assembly protein 357244001740 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001741 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001742 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001743 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001744 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001745 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244001746 conjugative transfer protein 357244001747 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001748 conjugative transfer protein 357244001749 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244001750 TraE protein; Region: TraE; cl05060 357244001751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244001752 active site 357244001753 Int/Topo IB signature motif; other site 357244001754 DNA binding site [nucleotide binding] 357244001755 transposase and inactivated derivative 357244001756 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 357244001757 Glycoprotease family; Region: Peptidase_M22; pfam00814 357244001758 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 357244001759 active site 357244001760 elongation factor P; Validated; Region: PRK00529 357244001761 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 357244001762 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 357244001763 RNA binding site [nucleotide binding]; other site 357244001764 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 357244001765 RNA binding site [nucleotide binding]; other site 357244001766 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 357244001767 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 357244001768 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244001769 Walker A motif; other site 357244001770 ATP binding site [chemical binding]; other site 357244001771 Walker B motif; other site 357244001772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357244001773 prolyl-tRNA synthetase; Provisional; Region: PRK12325 357244001774 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 357244001775 dimer interface [polypeptide binding]; other site 357244001776 motif 1; other site 357244001777 active site 357244001778 motif 2; other site 357244001779 motif 3; other site 357244001780 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 357244001781 anticodon binding site; other site 357244001782 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 357244001783 Phosphoglycerate kinase; Region: PGK; pfam00162 357244001784 substrate binding site [chemical binding]; other site 357244001785 hinge regions; other site 357244001786 ADP binding site [chemical binding]; other site 357244001787 catalytic site [active] 357244001788 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357244001789 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 357244001790 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357244001791 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 357244001792 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 357244001793 transposase and inactivated derivative 357244001794 transposase and inactivated derivative 357244001795 RNA-directed DNA polymerase (Reverse transcriptase) 357244001796 conserved hypothetical protein 357244001797 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244001798 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001799 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001800 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001801 site-specific DNA adenine methylase 357244001802 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001803 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244001804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244001805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244001806 ATP binding site [chemical binding]; other site 357244001807 Mg2+ binding site [ion binding]; other site 357244001808 G-X-G motif; other site 357244001809 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244001810 HD domain; Region: HD_4; pfam13328 357244001811 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244001812 conjugative transfer protein 357244001813 transposase and inactivated derivative 357244001814 conjugative transfer protein 357244001815 conjugative transfer protein 357244001816 transposase and inactivated derivative 357244001817 conjugative transfer protein 357244001818 transposase and inactivated derivative 357244001819 conjugative transfer protein 357244001820 transposase and inactivated derivative 357244001821 conserved hypothetical protein 357244001822 replicative DNA helicase 357244001823 RNA-directed DNA polymerase (Reverse transcriptase) 357244001824 conjugative transfer protein 357244001825 conjugative transfer protein 357244001826 conjugative pilus assembly protein 357244001827 conjugative pilus assembly protein 357244001828 conjugative transfer protein 357244001829 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244001830 conjugative transfer protein 357244001831 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244001832 TraE protein; Region: TraE; cl05060 357244001833 phage-related integrase 357244001834 transposase and inactivated derivative 357244001835 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 357244001836 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357244001837 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244001838 Walker A/P-loop; other site 357244001839 ATP binding site [chemical binding]; other site 357244001840 Q-loop/lid; other site 357244001841 ABC transporter signature motif; other site 357244001842 Walker B; other site 357244001843 D-loop; other site 357244001844 H-loop/switch region; other site 357244001845 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cl00238 357244001846 conjugative transfer protein 357244001847 transposase and inactivated derivative 357244001848 Ulp1 protease family, C-terminal catalytic domain; Region: Peptidase_C48; cl17784 357244001849 conserved hypothetical protein 357244001850 replicative DNA helicase 357244001851 conserved hypothetical protein 357244001852 conserved hypothetical protein 357244001853 transposase and inactivated derivative 357244001854 RNA-directed DNA polymerase (Reverse transcriptase) 357244001855 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 357244001856 ferrochelatase; Reviewed; Region: hemH; PRK00035 357244001857 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 357244001858 C-terminal domain interface [polypeptide binding]; other site 357244001859 active site 357244001860 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 357244001861 active site 357244001862 N-terminal domain interface [polypeptide binding]; other site 357244001863 uroporphyrinogen decarboxylase; Validated; Region: hemE; PRK00115 357244001864 conjugative transfer protein 357244001865 transcription termination factor Rho; Provisional; Region: rho; PRK09376 357244001866 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 357244001867 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 357244001868 RNA binding site [nucleotide binding]; other site 357244001869 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 357244001870 multimer interface [polypeptide binding]; other site 357244001871 Walker A motif; other site 357244001872 ATP binding site [chemical binding]; other site 357244001873 Walker B motif; other site 357244001874 conserved hypothetical protein 357244001875 transposase and inactivated derivative 357244001876 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 357244001877 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 357244001878 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 357244001879 thymidylate kinase; Validated; Region: tmk; PRK00698 357244001880 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 357244001881 TMP-binding site; other site 357244001882 ATP-binding site [chemical binding]; other site 357244001883 Predicted ATPase [General function prediction only]; Region: COG1485 357244001884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357244001885 Walker A motif; other site 357244001886 ATP binding site [chemical binding]; other site 357244001887 uroporphyrinogen-III synthase 357244001888 GTP-binding protein Der; Reviewed; Region: PRK00093 357244001889 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 357244001890 G1 box; other site 357244001891 GTP/Mg2+ binding site [chemical binding]; other site 357244001892 Switch I region; other site 357244001893 G2 box; other site 357244001894 Switch II region; other site 357244001895 G3 box; other site 357244001896 G4 box; other site 357244001897 G5 box; other site 357244001898 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 357244001899 G1 box; other site 357244001900 GTP/Mg2+ binding site [chemical binding]; other site 357244001901 Switch I region; other site 357244001902 G2 box; other site 357244001903 G3 box; other site 357244001904 Switch II region; other site 357244001905 G4 box; other site 357244001906 G5 box; other site 357244001907 DNA polymerase I; Provisional; Region: PRK05755 357244001908 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 357244001909 active site 357244001910 metal binding site 1 [ion binding]; metal-binding site 357244001911 putative 5' ssDNA interaction site; other site 357244001912 metal binding site 3; metal-binding site 357244001913 metal binding site 2 [ion binding]; metal-binding site 357244001914 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 357244001915 putative DNA binding site [nucleotide binding]; other site 357244001916 putative metal binding site [ion binding]; other site 357244001917 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 357244001918 active site 357244001919 DNA binding site [nucleotide binding] 357244001920 catalytic site [active] 357244001921 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 357244001922 Na binding site [ion binding]; other site 357244001923 transposase and inactivated derivative 357244001924 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 357244001925 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 357244001926 catalytic residues [active] 357244001927 transposase and inactivated derivative 357244001928 transposase and inactivated derivative 357244001929 RNA-directed DNA polymerase (Reverse transcriptase) 357244001930 transposase and inactivated derivative 357244001931 transposase and inactivated derivative 357244001932 transposase and inactivated derivative 357244001933 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 357244001934 Protein export membrane protein; Region: SecD_SecF; pfam02355 357244001935 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 357244001936 MutS domain I; Region: MutS_I; pfam01624 357244001937 MutS domain II; Region: MutS_II; pfam05188 357244001938 MutS domain III; Region: MutS_III; pfam05192 357244001939 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 357244001940 Walker A/P-loop; other site 357244001941 ATP binding site [chemical binding]; other site 357244001942 Q-loop/lid; other site 357244001943 ABC transporter signature motif; other site 357244001944 Walker B; other site 357244001945 D-loop; other site 357244001946 H-loop/switch region; other site 357244001947 TLC ATP/ADP transporter; Region: TLC; pfam03219 357244001948 Predicted methyltransferases [General function prediction only]; Region: COG0313 357244001949 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 357244001950 putative SAM binding site [chemical binding]; other site 357244001951 putative homodimer interface [polypeptide binding]; other site 357244001952 seryl-tRNA synthetase; Provisional; Region: PRK05431 357244001953 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 357244001954 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 357244001955 dimer interface [polypeptide binding]; other site 357244001956 active site 357244001957 motif 1; other site 357244001958 motif 2; other site 357244001959 motif 3; other site 357244001960 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 357244001961 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 357244001962 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 357244001963 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357244001964 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357244001965 P-loop; other site 357244001966 Magnesium ion binding site [ion binding]; other site 357244001967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357244001968 Magnesium ion binding site [ion binding]; other site 357244001969 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 357244001970 ParB-like nuclease domain; Region: ParB; smart00470 357244001971 transposase and inactivated derivative 357244001972 transposase and inactivated derivative 357244001973 RNA-directed DNA polymerase (Reverse transcriptase) 357244001974 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 357244001975 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 357244001976 transposase and inactivated derivative 357244001977 transposase and inactivated derivative 357244001978 conserved hypothetical protein 357244001979 transposase and inactivated derivative 357244001980 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357244001981 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244001982 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001983 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244001984 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244001985 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244001986 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244001987 transposase and inactivated derivative 357244001988 transposase and inactivated derivative 357244001989 transposase and inactivated derivative 357244001990 hypothetical protein 357244001991 transposase and inactivated derivative 357244001992 transposase and inactivated derivative 357244001993 conjugative transfer protein 357244001994 transposase and inactivated derivative 357244001995 conjugative transfer protein 357244001996 conserved hypothetical protein 357244001997 conjugative transfer protein 357244001998 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 357244001999 RNA-directed DNA polymerase (Reverse transcriptase) 357244002000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 357244002001 Homeodomain-like domain; Region: HTH_23; pfam13384 357244002002 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357244002003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 357244002004 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244002005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002008 ATP binding site [chemical binding]; other site 357244002009 Mg2+ binding site [ion binding]; other site 357244002010 G-X-G motif; other site 357244002011 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244002012 HD domain; Region: HD_4; pfam13328 357244002013 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244002014 conjugative transfer protein 357244002015 putative transposase; Provisional; Region: PRK09857 357244002016 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244002017 conjugative transfer protein 357244002018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002019 TPR motif; other site 357244002020 TPR repeat; Region: TPR_11; pfam13414 357244002021 binding surface 357244002022 TPR repeat; Region: TPR_11; pfam13414 357244002023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002024 binding surface 357244002025 TPR motif; other site 357244002026 TPR repeat; Region: TPR_11; pfam13414 357244002027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002028 binding surface 357244002029 TPR motif; other site 357244002030 conjugative transfer protein 357244002031 conjugative pilus assembly protein 357244002032 conjugative pilus assembly protein 357244002033 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244002034 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002035 conjugative transfer protein 357244002036 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244002037 TraE protein; Region: TraE; cl05060 357244002038 phage-related integrase 357244002039 transposase and inactivated derivative 357244002040 hypothetical protein 357244002041 alcohol-acetaldehyde dehydrogenase 357244002042 transposase and inactivated derivative 357244002043 RNA-directed DNA polymerase (Reverse transcriptase) 357244002044 transposase and inactivated derivative 357244002045 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 357244002046 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357244002047 catalytic loop [active] 357244002048 iron binding site [ion binding]; other site 357244002049 chaperone protein HscA; Provisional; Region: hscA; PRK01433 357244002050 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 357244002051 nucleotide binding site [chemical binding]; other site 357244002052 putative NEF/HSP70 interaction site [polypeptide binding]; other site 357244002053 SBD interface [polypeptide binding]; other site 357244002054 co-chaperone HscB; Provisional; Region: hscB; PRK01356 357244002055 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357244002056 HSP70 interaction site [polypeptide binding]; other site 357244002057 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 357244002058 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 357244002059 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357244002060 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 357244002061 trimerization site [polypeptide binding]; other site 357244002062 active site 357244002063 cysteine desulfurase IscS 357244002064 Rrf2 family protein; Region: rrf2_super; TIGR00738 357244002065 Transcriptional regulator; Region: Rrf2; cl17282 357244002066 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 357244002067 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357244002068 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 357244002069 Cell division protein FtsA; Region: FtsA; smart00842 357244002070 Cell division protein FtsA; Region: FtsA; pfam14450 357244002071 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 357244002072 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357244002073 active site 357244002074 transposase and inactivated derivative 357244002075 transposase and inactivated derivative 357244002076 conserved hypothetical protein 357244002077 replicative DNA helicase 357244002078 phage-related integrase 357244002079 transposase and inactivated derivative 357244002080 conserved hypothetical protein 357244002081 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357244002082 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 357244002083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357244002084 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357244002085 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357244002086 DNA binding residues [nucleotide binding] 357244002087 DNA primase, catalytic core; Region: dnaG; TIGR01391 357244002088 CHC2 zinc finger; Region: zf-CHC2; cl17510 357244002089 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 357244002090 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 357244002091 active site 357244002092 metal binding site [ion binding]; metal-binding site 357244002093 interdomain interaction site; other site 357244002094 transposase and inactivated derivative 357244002095 DNA protecting protein DprA; Region: dprA; TIGR00732 357244002096 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 357244002097 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357244002098 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 357244002099 dimer interface [polypeptide binding]; other site 357244002100 decamer (pentamer of dimers) interface [polypeptide binding]; other site 357244002101 catalytic triad [active] 357244002102 peroxidatic and resolving cysteines [active] 357244002103 transposase and inactivated derivative 357244002104 RNA-directed DNA polymerase (Reverse transcriptase) 357244002105 phage-related integrase 357244002106 phage-related integrase 357244002107 transposase and inactivated derivative 357244002108 submitted as non-pseudo;RNA-directed DNA polymerase (Reverse transcriptase) 357244002109 ankyrin repeat protein; Provisional; Region: PHA03100 357244002110 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002111 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002112 Ankyrin repeat; Region: Ank; pfam00023 357244002113 PRANC domain; Region: PRANC; pfam09372 357244002114 transposase and inactivated derivative 357244002115 multifunctional aminopeptidase A; Provisional; Region: PRK00913 357244002116 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 357244002117 interface (dimer of trimers) [polypeptide binding]; other site 357244002118 Substrate-binding/catalytic site; other site 357244002119 Zn-binding sites [ion binding]; other site 357244002120 ATPase MipZ; Region: MipZ; pfam09140 357244002121 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357244002122 P-loop; other site 357244002123 Magnesium ion binding site [ion binding]; other site 357244002124 hypothetical protein 357244002125 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 357244002126 rRNA interaction site [nucleotide binding]; other site 357244002127 S8 interaction site; other site 357244002128 putative laminin-1 binding site; other site 357244002129 elongation factor Ts; Provisional; Region: tsf; PRK09377 357244002130 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 357244002131 Elongation factor TS; Region: EF_TS; pfam00889 357244002132 Elongation factor TS; Region: EF_TS; pfam00889 357244002133 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 357244002134 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 357244002135 putative tRNA-binding site [nucleotide binding]; other site 357244002136 B3/4 domain; Region: B3_4; pfam03483 357244002137 tRNA synthetase B5 domain; Region: B5; smart00874 357244002138 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 357244002139 dimer interface [polypeptide binding]; other site 357244002140 motif 1; other site 357244002141 motif 3; other site 357244002142 motif 2; other site 357244002143 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 357244002144 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 357244002145 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 357244002146 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 357244002147 dimer interface [polypeptide binding]; other site 357244002148 motif 1; other site 357244002149 active site 357244002150 motif 2; other site 357244002151 motif 3; other site 357244002152 spoT-like ppGpp hydrolase 357244002153 conjugative transfer protein 357244002154 transposase and inactivated derivative 357244002155 phage-related integrase 357244002156 RNA-directed DNA polymerase (Reverse transcriptase) 357244002157 transposase and inactivated derivative 357244002158 phage-related integrase 357244002159 conjugative transfer protein 357244002160 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244002161 conjugative transfer protein 357244002162 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002163 conjugative transfer protein 357244002164 ankyrin repeat protein with 8 ankyrin repeats 357244002165 conjugative pilus assembly protein 357244002166 conjugative pilus assembly protein 357244002167 conjugative transfer protein 357244002168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002169 TPR motif; other site 357244002170 TPR repeat; Region: TPR_11; pfam13414 357244002171 binding surface 357244002172 TPR repeat; Region: TPR_11; pfam13414 357244002173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002174 binding surface 357244002175 TPR motif; other site 357244002176 TPR repeat; Region: TPR_11; pfam13414 357244002177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002178 binding surface 357244002179 TPR motif; other site 357244002180 submitted as non-pseudo;conjugative transfer protein 357244002181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244002182 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244002183 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244002184 spoT-like ppGpp hydrolase 357244002185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002187 ATP binding site [chemical binding]; other site 357244002188 Mg2+ binding site [ion binding]; other site 357244002189 G-X-G motif; other site 357244002190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002191 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 357244002192 submitted as non-pseudo;site-specific DNA adenine methylase 357244002193 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002194 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244002195 RNA-directed DNA polymerase (Reverse transcriptase) 357244002196 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002197 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244002198 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244002199 HD domain; Region: HD_4; pfam13328 357244002200 replicative DNA helicase 357244002201 conserved hypothetical protein 357244002202 spoT-like ppGpp hydrolase 357244002203 site-specific DNA adenine methylase 357244002204 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002207 ATP binding site [chemical binding]; other site 357244002208 Mg2+ binding site [ion binding]; other site 357244002209 G-X-G motif; other site 357244002210 spoT-like ppGpp hydrolase 357244002211 conserved hypothetical protein 357244002212 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244002213 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244002214 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244002215 submitted as non-pseudo;conjugative transfer protein 357244002216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002217 TPR motif; other site 357244002218 TPR repeat; Region: TPR_11; pfam13414 357244002219 binding surface 357244002220 TPR repeat; Region: TPR_11; pfam13414 357244002221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002222 binding surface 357244002223 TPR motif; other site 357244002224 TPR repeat; Region: TPR_11; pfam13414 357244002225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002226 binding surface 357244002227 TPR motif; other site 357244002228 conjugative transfer protein 357244002229 conjugative pilus assembly protein 357244002230 conjugative pilus assembly protein 357244002231 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 357244002232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244002233 TPR repeat; Region: TPR_11; pfam13414 357244002234 binding surface 357244002235 TPR motif; other site 357244002236 transposase and inactivated derivative 357244002237 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002238 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244002239 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002240 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244002241 transposase and inactivated derivative 357244002242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244002243 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244002244 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244002245 submitted as non-pseudo;hypothetical protein 357244002246 transposase and inactivated derivative 357244002247 conjugative transfer protein 357244002248 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002249 conjugative transfer protein 357244002250 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 357244002251 TraE protein; Region: TraE; cl05060 357244002252 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244002253 active site 357244002254 Int/Topo IB signature motif; other site 357244002255 DNA binding site [nucleotide binding] 357244002256 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357244002257 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357244002258 Cu(I) binding site [ion binding]; other site 357244002259 hypothetical protein 357244002260 transposase and inactivated derivative 357244002261 transposase and inactivated derivative 357244002262 Na+/proline symporter/Histidine kinase/Response regualator receivor domain 357244002263 hypothetical protein 357244002264 hypothetical protein 357244002265 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 357244002266 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 357244002267 active site 357244002268 catalytic site [active] 357244002269 substrate binding site [chemical binding]; other site 357244002270 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 357244002271 UGMP family protein; Validated; Region: PRK09604 357244002272 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 357244002273 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 357244002274 septum formation inhibitor; Provisional; Region: minC; PRK00030 357244002275 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 357244002276 TolR protein; Region: tolR; TIGR02801 357244002277 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 357244002278 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 357244002279 dimer interface [polypeptide binding]; other site 357244002280 allosteric magnesium binding site [ion binding]; other site 357244002281 active site 357244002282 aspartate-rich active site metal binding site; other site 357244002283 Schiff base residues; other site 357244002284 transposase and inactivated derivative 357244002285 peptide chain release factor 357244002286 GTP-binding protein LepA; Provisional; Region: PRK05433 357244002287 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 357244002288 G1 box; other site 357244002289 putative GEF interaction site [polypeptide binding]; other site 357244002290 GTP/Mg2+ binding site [chemical binding]; other site 357244002291 Switch I region; other site 357244002292 G2 box; other site 357244002293 G3 box; other site 357244002294 Switch II region; other site 357244002295 G4 box; other site 357244002296 G5 box; other site 357244002297 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 357244002298 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 357244002299 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 357244002300 conjugative transfer protein 357244002301 RNA-directed DNA polymerase (Reverse transcriptase) 357244002302 transposase and inactivated derivative 357244002303 transposase and inactivated derivative 357244002304 transposase and inactivated derivative 357244002305 transposase and inactivated derivative 357244002306 transposase and inactivated derivative 357244002307 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357244002308 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357244002309 dimer interface [polypeptide binding]; other site 357244002310 ssDNA binding site [nucleotide binding]; other site 357244002311 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357244002312 transposase and inactivated derivative 357244002313 RNA-directed DNA polymerase (Reverse transcriptase) 357244002314 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244002315 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002316 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244002317 conserved hypothetical protein 357244002318 transposase and inactivated derivative 357244002319 transposase and inactivated derivative 357244002320 transposase and inactivated derivative 357244002321 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 357244002322 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 357244002323 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357244002324 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 357244002325 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357244002326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357244002327 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357244002328 DNA binding residues [nucleotide binding] 357244002329 transposase and inactivated derivative 357244002330 transposase and inactivated derivative 357244002331 Protein of unknown function (DUF461); Region: DUF461; pfam04314 357244002332 hypothetical protein 357244002333 RNA-directed DNA polymerase (Reverse transcriptase) 357244002334 ankyrin repeat protein with 8 ankyrin repeats 357244002335 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 357244002336 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244002337 submitted as non-pseudo;conjugative transfer protein 357244002338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244002339 active site 357244002340 Int/Topo IB signature motif; other site 357244002341 DNA binding site [nucleotide binding] 357244002342 conserved hypothetical protein 357244002343 transposase and inactivated derivative 357244002344 transposase and inactivated derivative 357244002345 transposase and inactivated derivative 357244002346 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357244002347 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357244002348 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357244002349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357244002350 active site 357244002351 phosphorylation site [posttranslational modification] 357244002352 intermolecular recognition site; other site 357244002353 dimerization interface [polypeptide binding]; other site 357244002354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244002355 Walker A motif; other site 357244002356 ATP binding site [chemical binding]; other site 357244002357 Walker B motif; other site 357244002358 arginine finger; other site 357244002359 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357244002360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357244002361 dimer interface [polypeptide binding]; other site 357244002362 phosphorylation site [posttranslational modification] 357244002363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002364 ATP binding site [chemical binding]; other site 357244002365 Mg2+ binding site [ion binding]; other site 357244002366 G-X-G motif; other site 357244002367 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 357244002368 Competence protein; Region: Competence; pfam03772 357244002369 conserved hypothetical protein 357244002370 replicative DNA helicase 357244002371 spoT-like ppGpp hydrolase 357244002372 site-specific DNA adenine methylase 357244002373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002374 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244002375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002377 ATP binding site [chemical binding]; other site 357244002378 Mg2+ binding site [ion binding]; other site 357244002379 G-X-G motif; other site 357244002380 spoT-like ppGpp hydrolase 357244002381 tetratricopeptide repeat protein with 12 trp repeats 357244002382 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244002383 conjugative transfer protein 357244002384 transposase and inactivated derivative 357244002385 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244002386 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244002387 Walker B motif; other site 357244002388 conjugative transfer protein 357244002389 conjugative pilus assembly protein 357244002390 conjugative pilus assembly protein 357244002391 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244002392 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002393 conjugative transfer protein 357244002394 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 357244002395 conjugative transfer protein 357244002396 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244002397 conjugative transfer protein 357244002398 phage-related integrase 357244002399 transposase and inactivated derivative 357244002400 RNA-directed DNA polymerase (Reverse transcriptase) 357244002401 conjugative pilus assembly protein 357244002402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244002403 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244002404 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244002405 transposase and inactivated derivative 357244002406 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 357244002407 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357244002408 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 357244002409 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 357244002410 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357244002411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357244002412 FeS/SAM binding site; other site 357244002413 transposase and inactivated derivative 357244002414 citrate synthase 357244002415 Predicted permeases [General function prediction only]; Region: COG0679 357244002416 Malic enzyme, N-terminal domain; Region: malic; pfam00390 357244002417 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 357244002418 putative NAD(P) binding site [chemical binding]; other site 357244002419 conjugative transfer protein 357244002420 transposase and inactivated derivative 357244002421 transposase and inactivated derivative 357244002422 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244002423 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 357244002424 ankyrin repeat protein with 4 ankyrin repeats 357244002425 transposase and inactivated derivative 357244002426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002428 ATP binding site [chemical binding]; other site 357244002429 Mg2+ binding site [ion binding]; other site 357244002430 G-X-G motif; other site 357244002431 transposase and inactivated derivative 357244002432 tetratricopeptide repeat protein with 7 trp repeats 357244002433 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244002434 conjugative transfer protein 357244002435 conjugative transfer protein 357244002436 tetratricopeptide repeat protein with 8 trp repeats 357244002437 conjugative pilus assembly protein 357244002438 conjugative transfer protein 357244002439 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002440 conjugative transfer protein 357244002441 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244002442 TraE protein; Region: TraE; cl05060 357244002443 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244002444 active site 357244002445 Int/Topo IB signature motif; other site 357244002446 DNA binding site [nucleotide binding] 357244002447 transposase and inactivated derivative 357244002448 RAP domain; Region: RAP; cl17746 357244002449 transposase and inactivated derivative 357244002450 rod shape-determining protein MreC; Provisional; Region: PRK13922 357244002451 rod shape-determining protein MreC; Region: MreC; pfam04085 357244002452 rod shape-determining protein MreB; Provisional; Region: PRK13927 357244002453 MreB and similar proteins; Region: MreB_like; cd10225 357244002454 nucleotide binding site [chemical binding]; other site 357244002455 Mg binding site [ion binding]; other site 357244002456 putative protofilament interaction site [polypeptide binding]; other site 357244002457 RodZ interaction site [polypeptide binding]; other site 357244002458 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357244002459 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357244002460 RNA-directed DNA polymerase (Reverse transcriptase) 357244002461 RNA-directed DNA polymerase (Reverse transcriptase) 357244002462 Clp protease; Region: CLP_protease; pfam00574 357244002463 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 357244002464 oligomer interface [polypeptide binding]; other site 357244002465 active site residues [active] 357244002466 transposase and inactivated derivative 357244002467 transposase and inactivated derivative 357244002468 transposase and inactivated derivative 357244002469 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 357244002470 active site 357244002471 transposase and inactivated derivative 357244002472 transposase and inactivated derivative 357244002473 transposase and inactivated derivative 357244002474 conjugative pilus assembly protein 357244002475 conserved hypothetical protein 357244002476 transposase and inactivated derivative 357244002477 transposase and inactivated derivative 357244002478 transposase and inactivated derivative 357244002479 transposase and inactivated derivative 357244002480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357244002481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357244002482 active site 357244002483 phosphorylation site [posttranslational modification] 357244002484 intermolecular recognition site; other site 357244002485 dimerization interface [polypeptide binding]; other site 357244002486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357244002487 DNA binding site [nucleotide binding] 357244002488 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 357244002489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357244002490 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 357244002491 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 357244002492 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 357244002493 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 357244002494 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 357244002495 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 357244002496 GatB domain; Region: GatB_Yqey; smart00845 357244002497 site-specific DNA adenine methylase 357244002498 ankyrin repeat protein with 1 ankyrin repeats 357244002499 RNA-directed DNA polymerase (Reverse transcriptase) 357244002500 transposase and inactivated derivative 357244002501 RNA-directed DNA polymerase (Reverse transcriptase) 357244002502 transposase and inactivated derivative 357244002503 transposase and inactivated derivative 357244002504 hypothetical protein 357244002505 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357244002506 Na binding site [ion binding]; other site 357244002507 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357244002509 dimer interface [polypeptide binding]; other site 357244002510 phosphorylation site [posttranslational modification] 357244002511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002512 ATP binding site [chemical binding]; other site 357244002513 Mg2+ binding site [ion binding]; other site 357244002514 G-X-G motif; other site 357244002515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357244002516 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357244002517 active site 357244002518 phosphorylation site [posttranslational modification] 357244002519 intermolecular recognition site; other site 357244002520 dimerization interface [polypeptide binding]; other site 357244002521 RNA-directed DNA polymerase (Reverse transcriptase) 357244002522 transposase and inactivated derivative 357244002523 transposase and inactivated derivative 357244002524 conserved hypothetical protein 357244002525 transposase and inactivated derivative 357244002526 transposase and inactivated derivative 357244002527 site-specific DNA adenine methylase 357244002528 site-specific DNA adenine methylase 357244002529 conserved hypothetical protein 357244002530 transposase and inactivated derivative 357244002531 RNA-directed DNA polymerase (Reverse transcriptase) 357244002532 aconitate hydratase 357244002533 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541 357244002534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244002535 Walker A/P-loop; other site 357244002536 ATP binding site [chemical binding]; other site 357244002537 Q-loop/lid; other site 357244002538 ABC transporter signature motif; other site 357244002539 Walker B; other site 357244002540 D-loop; other site 357244002541 H-loop/switch region; other site 357244002542 conserved hypothetical protein 357244002543 Protein of unknown function (DUF2670); Region: DUF2670; pfam10875 357244002544 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 357244002545 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 357244002546 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 357244002547 [2Fe-2S] cluster binding site [ion binding]; other site 357244002548 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 357244002549 Qi binding site; other site 357244002550 intrachain domain interface; other site 357244002551 interchain domain interface [polypeptide binding]; other site 357244002552 cytochrome b; Provisional; Region: CYTB; MTH00156 357244002553 heme bH binding site [chemical binding]; other site 357244002554 heme bL binding site [chemical binding]; other site 357244002555 Qo binding site; other site 357244002556 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 357244002557 interchain domain interface [polypeptide binding]; other site 357244002558 intrachain domain interface; other site 357244002559 Qi binding site; other site 357244002560 Qo binding site; other site 357244002561 transposase and inactivated derivative 357244002562 replicative DNA helicase 357244002563 transposase and inactivated derivative 357244002564 putrescine-ornithine antiporter 357244002565 conserved hypothetical protein 357244002566 transposase and inactivated derivative 357244002567 hypothetical protein 357244002568 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 357244002569 Fe-S cluster binding site [ion binding]; other site 357244002570 active site 357244002571 RNA-directed DNA polymerase (Reverse transcriptase) 357244002572 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244002573 active site 357244002574 Int/Topo IB signature motif; other site 357244002575 DNA binding site [nucleotide binding] 357244002576 phage-related integrase 357244002577 transposase and inactivated derivative 357244002578 transposase and inactivated derivative 357244002579 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 357244002580 nucleotide binding site [chemical binding]; other site 357244002581 substrate binding site [chemical binding]; other site 357244002582 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 357244002583 G1 box; other site 357244002584 GTP/Mg2+ binding site [chemical binding]; other site 357244002585 Switch I region; other site 357244002586 G2 box; other site 357244002587 G3 box; other site 357244002588 Switch II region; other site 357244002589 G4 box; other site 357244002590 G5 box; other site 357244002591 membrane protein insertase; Provisional; Region: PRK01318 357244002592 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 357244002593 amino acid transporter; Region: 2A0306; TIGR00909 357244002594 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 357244002595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002596 Mg2+ binding site [ion binding]; other site 357244002597 G-X-G motif; other site 357244002598 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 357244002599 anchoring element; other site 357244002600 dimer interface [polypeptide binding]; other site 357244002601 ATP binding site [chemical binding]; other site 357244002602 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 357244002603 active site 357244002604 putative metal-binding site [ion binding]; other site 357244002605 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 357244002606 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 357244002607 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357244002608 active site 357244002609 motif I; other site 357244002610 motif II; other site 357244002611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357244002612 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 357244002613 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 357244002614 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 357244002615 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 357244002616 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 357244002617 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 357244002618 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK06591 357244002619 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357244002620 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00200 357244002621 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357244002622 RNA-directed DNA polymerase (Reverse transcriptase) 357244002623 transposase and inactivated derivative 357244002624 transposase and inactivated derivative 357244002625 transposase and inactivated derivative 357244002626 transposase and inactivated derivative 357244002627 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244002628 conserved hypothetical protein 357244002629 phage-related integrase 357244002630 conjugative transfer protein 357244002631 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244002632 conjugative transfer protein 357244002633 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002634 conjugative transfer protein 357244002635 F plasmid transfer operon protein; Region: TraF; pfam13728 357244002636 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 357244002637 conjugative pilus assembly protein 357244002638 conjugative transfer protein 357244002639 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244002640 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244002641 Walker B motif; other site 357244002642 putative transposase; Provisional; Region: PRK09857 357244002643 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244002644 conjugative transfer protein 357244002645 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244002646 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244002647 HD domain; Region: HD_4; pfam13328 357244002648 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002649 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244002650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002652 ATP binding site [chemical binding]; other site 357244002653 Mg2+ binding site [ion binding]; other site 357244002654 G-X-G motif; other site 357244002655 hypothetical protein 357244002656 hypothetical protein 357244002657 submitted as non-pseudo;site-specific DNA adenine methylase 357244002658 spoT-like ppGpp hydrolase 357244002659 replicative DNA helicase 357244002660 conserved hypothetical protein 357244002661 conjugative pilus assembly protein 357244002662 phage-related integrase 357244002663 transposase and inactivated derivative 357244002664 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357244002665 active site 357244002666 PQQ-like domain; Region: PQQ_2; pfam13360 357244002667 Trp docking motif [polypeptide binding]; other site 357244002668 Protein of unknown function (DUF2659); Region: DUF2659; pfam10858 357244002669 transposase and inactivated derivative 357244002670 transposase and inactivated derivative 357244002671 transposase and inactivated derivative 357244002672 transposase and inactivated derivative 357244002673 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244002674 Walker B motif; other site 357244002675 conjugative transfer protein 357244002676 conjugative pilus assembly protein 357244002677 conjugative pilus assembly protein 357244002678 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244002679 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002680 conjugative transfer protein 357244002681 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 357244002682 conjugative transfer protein 357244002683 transposase and inactivated derivative 357244002684 transposase and inactivated derivative 357244002685 transposase and inactivated derivative 357244002686 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 357244002687 Domain of unknown function DUF21; Region: DUF21; pfam01595 357244002688 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 357244002689 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357244002690 Transporter associated domain; Region: CorC_HlyC; smart01091 357244002691 RNA-directed DNA polymerase (Reverse transcriptase) 357244002692 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 357244002693 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 357244002694 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 357244002695 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 357244002696 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 357244002697 TPP-binding site [chemical binding]; other site 357244002698 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 357244002699 dimer interface [polypeptide binding]; other site 357244002700 PYR/PP interface [polypeptide binding]; other site 357244002701 TPP binding site [chemical binding]; other site 357244002702 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 357244002703 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357244002704 E3 interaction surface; other site 357244002705 lipoyl attachment site [posttranslational modification]; other site 357244002706 e3 binding domain; Region: E3_binding; pfam02817 357244002707 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357244002708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244002709 metabolite-proton symporter; Region: 2A0106; TIGR00883 357244002710 putative substrate translocation pore; other site 357244002711 hypothetical protein; Reviewed; Region: PRK12497 357244002712 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 357244002713 Subunit III/VIIa interface [polypeptide binding]; other site 357244002714 Phospholipid binding site [chemical binding]; other site 357244002715 Subunit I/III interface [polypeptide binding]; other site 357244002716 Subunit III/VIb interface [polypeptide binding]; other site 357244002717 Subunit III/VIa interface; other site 357244002718 Subunit III/Vb interface [polypeptide binding]; other site 357244002719 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 357244002720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244002721 Walker A motif; other site 357244002722 ATP binding site [chemical binding]; other site 357244002723 Walker B motif; other site 357244002724 arginine finger; other site 357244002725 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 357244002726 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 357244002727 RuvA N terminal domain; Region: RuvA_N; pfam01330 357244002728 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 357244002729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244002730 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357244002731 putative substrate translocation pore; other site 357244002732 submitted as non-pseudo;hypothetical protein 357244002733 transposase and inactivated derivative 357244002734 transposase and inactivated derivative 357244002735 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 357244002736 Na binding site [ion binding]; other site 357244002737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244002738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357244002739 dimer interface [polypeptide binding]; other site 357244002740 phosphorylation site [posttranslational modification] 357244002741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244002742 ATP binding site [chemical binding]; other site 357244002743 Mg2+ binding site [ion binding]; other site 357244002744 G-X-G motif; other site 357244002745 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357244002746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357244002747 active site 357244002748 phosphorylation site [posttranslational modification] 357244002749 intermolecular recognition site; other site 357244002750 dimerization interface [polypeptide binding]; other site 357244002751 transposase and inactivated derivative 357244002752 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244002753 active site 357244002754 Int/Topo IB signature motif; other site 357244002755 DNA binding site [nucleotide binding] 357244002756 TraE protein; Region: TraE; cl05060 357244002757 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 357244002758 conjugative transfer protein 357244002759 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244002760 conjugative transfer protein 357244002761 conjugative pilus assembly protein 357244002762 conjugative pilus assembly protein 357244002763 conjugative transfer protein 357244002764 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244002765 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244002766 Walker B motif; other site 357244002767 putative transposase; Provisional; Region: PRK09857 357244002768 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244002769 conjugative transfer protein 357244002770 ankyrin repeat protein; Provisional; Region: PHA02874 357244002771 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002772 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002773 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244002774 PRANC domain; Region: PRANC; pfam09372 357244002775 conjugative transfer protein 357244002776 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244002777 tetratricopeptide repeat protein with 8 trp repeats 357244002778 transposase and inactivated derivative 357244002779 lipoate-protein ligase B; Provisional; Region: PRK14341 357244002780 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01368 357244002781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357244002782 cell division protein FtsW; Region: ftsW; TIGR02614 357244002783 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 357244002784 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 357244002785 active site 357244002786 homodimer interface [polypeptide binding]; other site 357244002787 RNA-directed DNA polymerase (Reverse transcriptase) 357244002788 RNA-directed DNA polymerase (Reverse transcriptase) 357244002789 transposase and inactivated derivative 357244002790 RNA-directed DNA polymerase (Reverse transcriptase) 357244002791 transposase and inactivated derivative 357244002792 transposase and inactivated derivative 357244002793 aspartate kinase; Reviewed; Region: PRK06635 357244002794 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 357244002795 putative catalytic residues [active] 357244002796 putative nucleotide binding site [chemical binding]; other site 357244002797 putative aspartate binding site [chemical binding]; other site 357244002798 Bacterial SH3 domain; Region: SH3_4; pfam06347 357244002799 Bacterial SH3 domain; Region: SH3_4; pfam06347 357244002800 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 357244002801 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 357244002802 TrkA-N domain; Region: TrkA_N; pfam02254 357244002803 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 357244002804 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 357244002805 Colicin V production protein; Region: Colicin_V; pfam02674 357244002806 conjugative transfer protein 357244002807 conjugative transfer protein 357244002808 conjugative pilus assembly protein 357244002809 transposase and inactivated derivative 357244002810 RNA-directed DNA polymerase (Reverse transcriptase) 357244002811 transposase and inactivated derivative 357244002812 phage-related integrase 357244002813 transposase and inactivated derivative 357244002814 transposase and inactivated derivative 357244002815 submitted as non-pseudo;conserved hypothetical protein 357244002816 transposase and inactivated derivative 357244002817 submitted as non-pseudo;hypothetical protein 357244002818 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 357244002819 homodimer interface [polypeptide binding]; other site 357244002820 oligonucleotide binding site [chemical binding]; other site 357244002821 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357244002822 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 357244002823 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244002824 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357244002825 synthetase active site [active] 357244002826 NTP binding site [chemical binding]; other site 357244002827 metal binding site [ion binding]; metal-binding site 357244002828 RNA-directed DNA polymerase (Reverse transcriptase) 357244002829 transposase and inactivated derivative 357244002830 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 357244002831 ABC1 family; Region: ABC1; pfam03109 357244002832 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 357244002833 active site 357244002834 ATP binding site [chemical binding]; other site 357244002835 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 357244002836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357244002837 S-adenosylmethionine binding site [chemical binding]; other site 357244002838 ribosome maturation protein RimP; Reviewed; Region: PRK00092 357244002839 Sm and related proteins; Region: Sm_like; cl00259 357244002840 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 357244002841 putative oligomer interface [polypeptide binding]; other site 357244002842 putative RNA binding site [nucleotide binding]; other site 357244002843 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 357244002844 NusA N-terminal domain; Region: NusA_N; pfam08529 357244002845 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 357244002846 RNA binding site [nucleotide binding]; other site 357244002847 homodimer interface [polypeptide binding]; other site 357244002848 NusA-like KH domain; Region: KH_5; pfam13184 357244002849 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 357244002850 G-X-X-G motif; other site 357244002851 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 357244002852 translation initiation factor IF-2; Region: IF-2; TIGR00487 357244002853 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 357244002854 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 357244002855 G1 box; other site 357244002856 putative GEF interaction site [polypeptide binding]; other site 357244002857 GTP/Mg2+ binding site [chemical binding]; other site 357244002858 Switch I region; other site 357244002859 G2 box; other site 357244002860 G3 box; other site 357244002861 Switch II region; other site 357244002862 G4 box; other site 357244002863 G5 box; other site 357244002864 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 357244002865 Translation-initiation factor 2; Region: IF-2; pfam11987 357244002866 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 357244002867 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 357244002868 RNA-directed DNA polymerase (Reverse transcriptase) 357244002869 transposase and inactivated derivative 357244002870 transposase and inactivated derivative 357244002871 transposase and inactivated derivative 357244002872 transposase and inactivated derivative 357244002873 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357244002874 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 357244002875 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 357244002876 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 357244002877 Ferredoxin [Energy production and conversion]; Region: COG1146 357244002878 4Fe-4S binding domain; Region: Fer4; pfam00037 357244002879 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 357244002880 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357244002881 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 357244002882 submitted as non-pseudo;hypothetical protein 357244002883 Stringent starvation protein B; Region: SspB; pfam04386 357244002884 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 357244002885 RNA/DNA hybrid binding site [nucleotide binding]; other site 357244002886 active site 357244002887 NADH ubiquinone oxidoreductase subunit NDUFA12; Region: NDUFA12; pfam05071 357244002888 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 357244002889 mce related protein; Region: MCE; pfam02470 357244002890 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 357244002891 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357244002892 dimer interface [polypeptide binding]; other site 357244002893 motif 1; other site 357244002894 active site 357244002895 motif 2; other site 357244002896 motif 3; other site 357244002897 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 357244002898 anticodon binding site; other site 357244002899 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 357244002900 putative RNA binding site [nucleotide binding]; other site 357244002901 submitted as non-pseudo;hypothetical protein 357244002902 transposase and inactivated derivative 357244002903 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357244002904 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 357244002905 C-terminal domain interface [polypeptide binding]; other site 357244002906 GSH binding site (G-site) [chemical binding]; other site 357244002907 dimer interface [polypeptide binding]; other site 357244002908 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 357244002909 N-terminal domain interface [polypeptide binding]; other site 357244002910 dimer interface [polypeptide binding]; other site 357244002911 substrate binding pocket (H-site) [chemical binding]; other site 357244002912 conjugative pilus assembly protein 357244002913 transposase and inactivated derivative 357244002914 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244002915 HD domain; Region: HD_4; pfam13328 357244002916 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244002917 conjugative transfer protein 357244002918 signal transduction histidine kinase 357244002919 transposase and inactivated derivative 357244002920 hypothetical protein 357244002921 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244002922 conserved hypothetical protein 357244002923 RNA-directed DNA polymerase (Reverse transcriptase) 357244002924 transposase and inactivated derivative 357244002925 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 357244002926 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357244002927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244002928 Walker A motif; other site 357244002929 ATP binding site [chemical binding]; other site 357244002930 Walker B motif; other site 357244002931 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 357244002932 RNA-directed DNA polymerase (Reverse transcriptase) 357244002933 hypothetical protein 357244002934 transposase and inactivated derivative 357244002935 RNA-directed DNA polymerase (Reverse transcriptase) 357244002936 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 357244002937 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 357244002938 nucleotide binding site [chemical binding]; other site 357244002939 SulA interaction site; other site 357244002940 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 357244002941 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 357244002942 hinge; other site 357244002943 active site 357244002944 transposase and inactivated derivative 357244002945 conjugative pilus assembly protein 357244002946 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 357244002947 proline/betaine transporter 357244002948 transposase and inactivated derivative 357244002949 submitted as non-pseudo;hypothetical protein 357244002950 transposase and inactivated derivative 357244002951 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 357244002952 NADH dehydrogenase subunit B; Validated; Region: PRK06411 357244002953 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 357244002954 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 357244002955 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 357244002956 NADH dehydrogenase subunit D; Validated; Region: PRK06075 357244002957 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 357244002958 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 357244002959 putative dimer interface [polypeptide binding]; other site 357244002960 [2Fe-2S] cluster binding site [ion binding]; other site 357244002961 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 357244002962 SLBB domain; Region: SLBB; pfam10531 357244002963 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 357244002964 transposase and inactivated derivative 357244002965 transposase and inactivated derivative 357244002966 TLC ATP/ADP transporter; Region: TLC; pfam03219 357244002967 VirB2-like type IV secretion system protein 357244002968 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 357244002969 active site 357244002970 putative DNA-binding cleft [nucleotide binding]; other site 357244002971 dimer interface [polypeptide binding]; other site 357244002972 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 357244002973 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 357244002974 FMN binding site [chemical binding]; other site 357244002975 active site 357244002976 catalytic residues [active] 357244002977 substrate binding site [chemical binding]; other site 357244002978 hypothetical protein; Reviewed; Region: PRK01530 357244002979 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 357244002980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357244002981 S-adenosylmethionine binding site [chemical binding]; other site 357244002982 methylase 357244002983 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 357244002984 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 357244002985 dimerization interface 3.5A [polypeptide binding]; other site 357244002986 active site 357244002987 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 357244002988 23S rRNA interface [nucleotide binding]; other site 357244002989 L3 interface [polypeptide binding]; other site 357244002990 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 357244002991 transposase and inactivated derivative 357244002992 site-specific DNA adenine methylase 357244002993 conserved hypothetical protein 357244002994 transposase and inactivated derivative 357244002995 transposase and inactivated derivative 357244002996 transposase and inactivated derivative 357244002997 transposase and inactivated derivative 357244002998 conserved hypothetical protein 357244002999 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244003000 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003001 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244003002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003004 ATP binding site [chemical binding]; other site 357244003005 Mg2+ binding site [ion binding]; other site 357244003006 G-X-G motif; other site 357244003007 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003008 HD domain; Region: HD_4; pfam13328 357244003009 submitted as non-pseudo;hypothetical protein 357244003010 spoT-like ppGpp hydrolase 357244003011 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 357244003012 putative catalytic site [active] 357244003013 putative phosphate binding site [ion binding]; other site 357244003014 active site 357244003015 metal binding site A [ion binding]; metal-binding site 357244003016 DNA binding site [nucleotide binding] 357244003017 putative AP binding site [nucleotide binding]; other site 357244003018 putative metal binding site B [ion binding]; other site 357244003019 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244003020 conjugative transfer protein 357244003021 conjugative transfer protein 357244003022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003023 binding surface 357244003024 TPR motif; other site 357244003025 TPR repeat; Region: TPR_11; pfam13414 357244003026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003027 binding surface 357244003028 TPR motif; other site 357244003029 TPR repeat; Region: TPR_11; pfam13414 357244003030 TPR repeat; Region: TPR_11; pfam13414 357244003031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003032 binding surface 357244003033 TPR motif; other site 357244003034 TPR repeat; Region: TPR_11; pfam13414 357244003035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003036 binding surface 357244003037 TPR motif; other site 357244003038 conjugative pilus assembly protein 357244003039 conjugative transfer protein 357244003040 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244003041 conjugative transfer protein 357244003042 conjugative pilus assembly protein 357244003043 TraE protein; Region: TraE; cl05060 357244003044 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003045 active site 357244003046 Int/Topo IB signature motif; other site 357244003047 DNA binding site [nucleotide binding] 357244003048 transposase and inactivated derivative 357244003049 RNA-directed DNA polymerase (Reverse transcriptase) 357244003050 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003051 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003052 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003053 PRANC domain; Region: PRANC; pfam09372 357244003054 replicative DNA helicase 357244003055 conserved hypothetical protein 357244003056 Phage-related protein [Function unknown]; Region: COG4695 357244003057 Phage portal protein; Region: Phage_portal; pfam04860 357244003058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357244003059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357244003060 non-specific DNA binding site [nucleotide binding]; other site 357244003061 salt bridge; other site 357244003062 sequence-specific DNA binding site [nucleotide binding]; other site 357244003063 Autotransporter beta-domain; Region: Autotransporter; smart00869 357244003064 transposase and inactivated derivative 357244003065 submitted as non-pseudo;hypothetical protein 357244003066 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003067 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003068 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003069 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 357244003070 active site 357244003071 NTP binding site [chemical binding]; other site 357244003072 nucleic acid binding site [nucleotide binding]; other site 357244003073 RNA-directed DNA polymerase (Reverse transcriptase) 357244003074 transposase and inactivated derivative 357244003075 phage-related integrase 357244003076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003077 active site 357244003078 Int/Topo IB signature motif; other site 357244003079 DNA binding site [nucleotide binding] 357244003080 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 357244003081 Iron-sulfur protein interface; other site 357244003082 proximal quinone binding site [chemical binding]; other site 357244003083 SdhD (CybS) interface [polypeptide binding]; other site 357244003084 proximal heme binding site [chemical binding]; other site 357244003085 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 357244003086 putative SdhC subunit interface [polypeptide binding]; other site 357244003087 putative proximal heme binding site [chemical binding]; other site 357244003088 putative Iron-sulfur protein interface [polypeptide binding]; other site 357244003089 putative proximal quinone binding site; other site 357244003090 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 357244003091 L-aspartate oxidase; Provisional; Region: PRK06175 357244003092 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 357244003093 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 357244003094 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 357244003095 conjugative pilus assembly protein 357244003096 transposase and inactivated derivative 357244003097 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 357244003098 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357244003099 Catalytic site [active] 357244003100 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357244003101 ribonuclease III; Reviewed; Region: rnc; PRK00102 357244003102 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 357244003103 dimerization interface [polypeptide binding]; other site 357244003104 active site 357244003105 metal binding site [ion binding]; metal-binding site 357244003106 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 357244003107 dsRNA binding site [nucleotide binding]; other site 357244003108 transposase and inactivated derivative 357244003109 spoT-like ppGpp hydrolase 357244003110 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 357244003111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244003112 putative substrate translocation pore; other site 357244003113 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357244003114 putative acyl-acceptor binding pocket; other site 357244003115 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 357244003116 acyl-activating enzyme (AAE) consensus motif; other site 357244003117 putative AMP binding site [chemical binding]; other site 357244003118 Predicted esterase [General function prediction only]; Region: COG0400 357244003119 putative hydrolase; Provisional; Region: PRK11460 357244003120 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 357244003121 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357244003122 minor groove reading motif; other site 357244003123 helix-hairpin-helix signature motif; other site 357244003124 active site 357244003125 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 357244003126 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 357244003127 putative GSH binding site [chemical binding]; other site 357244003128 catalytic residues [active] 357244003129 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 357244003130 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 357244003131 transposase and inactivated derivative 357244003132 disulfide bond formation protein DsbB 357244003133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 357244003134 Cation efflux family; Region: Cation_efflux; cl00316 357244003135 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 357244003136 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 357244003137 nucleoside/Zn binding site; other site 357244003138 dimer interface [polypeptide binding]; other site 357244003139 catalytic motif [active] 357244003140 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 357244003141 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 357244003142 nucleotide binding pocket [chemical binding]; other site 357244003143 K-X-D-G motif; other site 357244003144 catalytic site [active] 357244003145 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 357244003146 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 357244003147 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 357244003148 Dimer interface [polypeptide binding]; other site 357244003149 BRCT sequence motif; other site 357244003150 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 357244003151 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357244003152 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 357244003153 active site 357244003154 transposase and inactivated derivative 357244003155 site-specific DNA adenine methylase 357244003156 signal transduction histidine kinase 357244003157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003158 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003159 ATP binding site [chemical binding]; other site 357244003160 Mg2+ binding site [ion binding]; other site 357244003161 G-X-G motif; other site 357244003162 signal transduction histidine kinase 357244003163 spoT-like ppGpp hydrolase 357244003164 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003165 active site 357244003166 Int/Topo IB signature motif; other site 357244003167 DNA binding site [nucleotide binding] 357244003168 TraE protein; Region: TraE; cl05060 357244003169 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244003170 conjugative transfer protein 357244003171 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244003172 conjugative transfer protein 357244003173 conjugative pilus assembly protein 357244003174 conjugative pilus assembly protein 357244003175 conjugative transfer protein 357244003176 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244003177 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357244003178 Walker B motif; other site 357244003179 putative transposase; Provisional; Region: PRK09857 357244003180 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244003181 conjugative transfer protein 357244003182 cytochrome b 357244003183 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244003184 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003185 HD domain; Region: HD_4; pfam13328 357244003186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003187 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244003188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003190 ATP binding site [chemical binding]; other site 357244003191 Mg2+ binding site [ion binding]; other site 357244003192 G-X-G motif; other site 357244003193 conserved hypothetical protein 357244003194 hypothetical protein 357244003195 submitted as non-pseudo;site-specific DNA adenine methylase 357244003196 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003197 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003198 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003199 spoT-like ppGpp hydrolase 357244003200 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003201 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003202 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003203 Ankyrin repeat; Region: Ank; pfam00023 357244003204 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003205 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003206 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003207 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003208 submitted as non-pseudo;hypothetical protein 357244003209 transposase and inactivated derivative 357244003210 transposase and inactivated derivative 357244003211 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 357244003212 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 357244003213 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 357244003214 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 357244003215 transposase and inactivated derivative 357244003216 transposase and inactivated derivative 357244003217 transposase and inactivated derivative 357244003218 transposase and inactivated derivative 357244003219 aspartate aminotransferase; Provisional; Region: PRK05764 357244003220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357244003221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357244003222 homodimer interface [polypeptide binding]; other site 357244003223 catalytic residue [active] 357244003224 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357244003225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357244003226 S-adenosylmethionine binding site [chemical binding]; other site 357244003227 VacJ like lipoprotein; Region: VacJ; cl01073 357244003228 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 357244003229 oxygen-independent coproporphyrinogen III oxidase;truncated 357244003230 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 357244003231 Recombination protein O N terminal; Region: RecO_N; pfam11967 357244003232 Recombination protein O C terminal; Region: RecO_C; pfam02565 357244003233 conjugative transfer protein 357244003234 transposase and inactivated derivative 357244003235 transposase and inactivated derivative 357244003236 replicative DNA helicase 357244003237 phage-related integrase 357244003238 transposase and inactivated derivative 357244003239 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 357244003240 Protein of unknown function (DUF721); Region: DUF721; pfam05258 357244003241 hypothetical protein; Reviewed; Region: PRK00024 357244003242 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 357244003243 MPN+ (JAMM) motif; other site 357244003244 Zinc-binding site [ion binding]; other site 357244003245 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 357244003246 S17 interaction site [polypeptide binding]; other site 357244003247 S8 interaction site; other site 357244003248 16S rRNA interaction site [nucleotide binding]; other site 357244003249 streptomycin interaction site [chemical binding]; other site 357244003250 23S rRNA interaction site [nucleotide binding]; other site 357244003251 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 357244003252 30S ribosomal protein S7; Validated; Region: PRK05302 357244003253 elongation factor G; Reviewed; Region: PRK00007 357244003254 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 357244003255 G1 box; other site 357244003256 putative GEF interaction site [polypeptide binding]; other site 357244003257 GTP/Mg2+ binding site [chemical binding]; other site 357244003258 Switch I region; other site 357244003259 G2 box; other site 357244003260 G3 box; other site 357244003261 Switch II region; other site 357244003262 G4 box; other site 357244003263 G5 box; other site 357244003264 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357244003265 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357244003266 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357244003267 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 357244003268 RNA binding site [nucleotide binding]; other site 357244003269 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 357244003270 RNA binding site [nucleotide binding]; other site 357244003271 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357244003272 RNA binding site [nucleotide binding]; other site 357244003273 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357244003274 RNA binding site [nucleotide binding]; other site 357244003275 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 357244003276 RNA binding site [nucleotide binding]; other site 357244003277 transposase and inactivated derivative 357244003278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 357244003279 Homeodomain-like domain; Region: HTH_23; pfam13384 357244003280 DDE superfamily endonuclease; Region: DDE_3; pfam13358 357244003281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 357244003282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357244003283 DNA-binding site [nucleotide binding]; DNA binding site 357244003284 RNA-binding motif; other site 357244003285 transposase and inactivated derivative 357244003286 transposase and inactivated derivative 357244003287 submitted as non-pseudo;hypothetical protein 357244003288 transposase and inactivated derivative 357244003289 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 357244003290 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 357244003291 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 357244003292 transposase and inactivated derivative 357244003293 submitted as non-pseudo;conserved hypothetical protein 357244003294 NADH dehydrogenase I chain N 357244003295 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 357244003296 nucleotide binding site/active site [active] 357244003297 HIT family signature motif; other site 357244003298 catalytic residue [active] 357244003299 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 357244003300 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357244003301 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 357244003302 UbiA prenyltransferase family; Region: UbiA; pfam01040 357244003303 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357244003304 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 357244003305 Subunit I/III interface [polypeptide binding]; other site 357244003306 D-pathway; other site 357244003307 Subunit I/VIIc interface [polypeptide binding]; other site 357244003308 Subunit I/IV interface [polypeptide binding]; other site 357244003309 Subunit I/II interface [polypeptide binding]; other site 357244003310 Low-spin heme (heme a) binding site [chemical binding]; other site 357244003311 Subunit I/VIIa interface [polypeptide binding]; other site 357244003312 Subunit I/VIa interface [polypeptide binding]; other site 357244003313 Dimer interface; other site 357244003314 Putative water exit pathway; other site 357244003315 Binuclear center (heme a3/CuB) [ion binding]; other site 357244003316 K-pathway; other site 357244003317 Subunit I/Vb interface [polypeptide binding]; other site 357244003318 Putative proton exit pathway; other site 357244003319 Subunit I/VIb interface; other site 357244003320 Subunit I/VIc interface [polypeptide binding]; other site 357244003321 Electron transfer pathway; other site 357244003322 Subunit I/VIIIb interface [polypeptide binding]; other site 357244003323 Subunit I/VIIb interface [polypeptide binding]; other site 357244003324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 357244003325 Terminase-like family; Region: Terminase_6; pfam03237 357244003326 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 357244003327 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 357244003328 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 357244003329 5S rRNA interface [nucleotide binding]; other site 357244003330 CTC domain interface [polypeptide binding]; other site 357244003331 L16 interface [polypeptide binding]; other site 357244003332 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 357244003333 putative active site [active] 357244003334 catalytic residue [active] 357244003335 GTP-binding protein YchF; Reviewed; Region: PRK09601 357244003336 YchF GTPase; Region: YchF; cd01900 357244003337 G1 box; other site 357244003338 GTP/Mg2+ binding site [chemical binding]; other site 357244003339 Switch I region; other site 357244003340 G2 box; other site 357244003341 Switch II region; other site 357244003342 G3 box; other site 357244003343 G4 box; other site 357244003344 G5 box; other site 357244003345 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 357244003346 transposase and inactivated derivative 357244003347 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 357244003348 putative catalytic site [active] 357244003349 putative phosphate binding site [ion binding]; other site 357244003350 active site 357244003351 metal binding site A [ion binding]; metal-binding site 357244003352 DNA binding site [nucleotide binding] 357244003353 putative AP binding site [nucleotide binding]; other site 357244003354 putative metal binding site B [ion binding]; other site 357244003355 RNA-directed DNA polymerase (Reverse transcriptase) 357244003356 submitted as non-pseudo;hypothetical protein 357244003357 transposase and inactivated derivative 357244003358 transposase and inactivated derivative 357244003359 transposase and inactivated derivative 357244003360 RNA-directed DNA polymerase (Reverse transcriptase) 357244003361 conjugative transfer protein 357244003362 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357244003363 Cytochrome c2 [Energy production and conversion]; Region: COG3474 357244003364 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357244003365 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 357244003366 replicative DNA helicase 357244003367 conserved hypothetical protein 357244003368 spoT-like ppGpp hydrolase 357244003369 RNA-directed DNA polymerase (Reverse transcriptase) 357244003370 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 357244003371 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 357244003372 active site 357244003373 HIGH motif; other site 357244003374 dimer interface [polypeptide binding]; other site 357244003375 KMSKS motif; other site 357244003376 transposase and inactivated derivative 357244003377 transposase and inactivated derivative 357244003378 transposase and inactivated derivative 357244003379 transposase and inactivated derivative 357244003380 phage-related integrase 357244003381 RNA-directed DNA polymerase (Reverse transcriptase) 357244003382 replicative DNA helicase 357244003383 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 357244003384 Walker A motif; other site 357244003385 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 357244003386 HflK protein; Region: hflK; TIGR01933 357244003387 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357244003388 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 357244003389 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 357244003390 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357244003391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357244003392 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357244003393 protein binding site [polypeptide binding]; other site 357244003394 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 357244003395 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357244003396 ligand binding site [chemical binding]; other site 357244003397 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 357244003398 Putative phage tail protein; Region: Phage-tail_3; pfam13550 357244003399 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 357244003400 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357244003401 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 357244003402 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 357244003403 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 357244003404 homodimer interface [polypeptide binding]; other site 357244003405 NADP binding site [chemical binding]; other site 357244003406 substrate binding site [chemical binding]; other site 357244003407 DNA topoisomerase I; Validated; Region: PRK06599 357244003408 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 357244003409 active site 357244003410 interdomain interaction site; other site 357244003411 putative metal-binding site [ion binding]; other site 357244003412 nucleotide binding site [chemical binding]; other site 357244003413 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 357244003414 domain I; other site 357244003415 DNA binding groove [nucleotide binding] 357244003416 phosphate binding site [ion binding]; other site 357244003417 domain II; other site 357244003418 domain III; other site 357244003419 nucleotide binding site [chemical binding]; other site 357244003420 catalytic site [active] 357244003421 domain IV; other site 357244003422 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 357244003423 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 357244003424 malate dehydrogenase; Reviewed; Region: PRK06223 357244003425 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 357244003426 NAD(P) binding site [chemical binding]; other site 357244003427 dimer interface [polypeptide binding]; other site 357244003428 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357244003429 substrate binding site [chemical binding]; other site 357244003430 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 357244003431 RimM N-terminal domain; Region: RimM; pfam01782 357244003432 PRC-barrel domain; Region: PRC; pfam05239 357244003433 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 357244003434 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 357244003435 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 357244003436 putative active site [active] 357244003437 substrate binding site [chemical binding]; other site 357244003438 putative cosubstrate binding site; other site 357244003439 catalytic site [active] 357244003440 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 357244003441 substrate binding site [chemical binding]; other site 357244003442 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 357244003443 active site 357244003444 catalytic residues [active] 357244003445 metal binding site [ion binding]; metal-binding site 357244003446 conserved hypothetical protein 357244003447 replicative DNA helicase 357244003448 spoT-like ppGpp hydrolase 357244003449 hypothetical protein 357244003450 site-specific DNA adenine methylase 357244003451 transposase and inactivated derivative 357244003452 tetratricopeptide repeat protein with 8 trp repeats 357244003453 conjugative transfer protein 357244003454 conjugative transfer protein 357244003455 transposase and inactivated derivative 357244003456 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 357244003457 active site 357244003458 multimer interface [polypeptide binding]; other site 357244003459 RNA-directed DNA polymerase (Reverse transcriptase) 357244003460 conserved hypothetical protein 357244003461 replicative DNA helicase 357244003462 phage-related integrase 357244003463 conjugative transfer protein 357244003464 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244003465 conjugative transfer protein 357244003466 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244003467 conjugative transfer protein 357244003468 F plasmid transfer operon protein; Region: TraF; pfam13728 357244003469 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 357244003470 conjugative pilus assembly protein 357244003471 conjugative transfer protein 357244003472 conjugative transfer protein 357244003473 site-specific DNA adenine methylase 357244003474 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 357244003475 transposase and inactivated derivative 357244003476 conjugative pilus assembly protein 357244003477 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 357244003478 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 357244003479 transposase and inactivated derivative 357244003480 transposase and inactivated derivative 357244003481 RNA-directed DNA polymerase (Reverse transcriptase) 357244003482 hypothetical protein 357244003483 transposase and inactivated derivative 357244003484 transposase and inactivated derivative 357244003485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244003486 putative substrate translocation pore; other site 357244003487 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003488 active site 357244003489 Int/Topo IB signature motif; other site 357244003490 DNA binding site [nucleotide binding] 357244003491 TraE protein; Region: TraE; cl05060 357244003492 hypothetical protein 357244003493 conserved hypothetical protein 357244003494 conjugative transfer protein 357244003495 conjugative pilus assembly protein 357244003496 transposase and inactivated derivative 357244003497 conserved hypothetical protein 357244003498 phage-related integrase 357244003499 hypothetical protein 357244003500 RNA-directed DNA polymerase (Reverse transcriptase) 357244003501 transposase and inactivated derivative 357244003502 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357244003503 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 357244003504 ABC-ATPase subunit interface; other site 357244003505 dimer interface [polypeptide binding]; other site 357244003506 putative PBP binding regions; other site 357244003507 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357244003508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244003509 Walker A/P-loop; other site 357244003510 ATP binding site [chemical binding]; other site 357244003511 Q-loop/lid; other site 357244003512 ABC transporter signature motif; other site 357244003513 Walker B; other site 357244003514 D-loop; other site 357244003515 H-loop/switch region; other site 357244003516 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 357244003517 hypothetical protein; Validated; Region: PRK00153 357244003518 DNA polymerase III subunits gamma and tau; Validated; Region: PRK06645 357244003519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244003520 Walker B motif; other site 357244003521 arginine finger; other site 357244003522 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 357244003523 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 357244003524 Autotransporter beta-domain; Region: Autotransporter; smart00869 357244003525 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357244003526 substrate binding pocket [chemical binding]; other site 357244003527 membrane-bound complex binding site; other site 357244003528 UPF0126 domain; Region: UPF0126; pfam03458 357244003529 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 357244003530 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 357244003531 generic binding surface I; other site 357244003532 generic binding surface II; other site 357244003533 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 357244003534 putative hydrolase; Provisional; Region: PRK02113 357244003535 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 357244003536 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 357244003537 active site 357244003538 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 357244003539 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 357244003540 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 357244003541 RNA-directed DNA polymerase (Reverse transcriptase) 357244003542 transposase and inactivated derivative 357244003543 transposase and inactivated derivative 357244003544 conjugative transfer protein 357244003545 transposase and inactivated derivative 357244003546 conserved hypothetical protein 357244003547 hypothetical protein 357244003548 exodeoxyribonuclease III 357244003549 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 357244003550 transposase and inactivated derivative 357244003551 conserved hypothetical protein 357244003552 replicative DNA helicase 357244003553 transposase and inactivated derivative 357244003554 transposase and inactivated derivative 357244003555 replicative DNA helicase 357244003556 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003557 HD domain; Region: HD_4; pfam13328 357244003558 hypothetical protein 357244003559 transposase and inactivated derivative 357244003560 transposase and inactivated derivative 357244003561 transposase and inactivated derivative 357244003562 hypothetical protein 357244003563 hypothetical protein 357244003564 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 357244003565 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 357244003566 phage-related integrase 357244003567 Mechanosensitive ion channel; Region: MS_channel; pfam00924 357244003568 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 357244003569 active site 357244003570 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 357244003571 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 357244003572 active site 357244003573 HIGH motif; other site 357244003574 KMSKS motif; other site 357244003575 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 357244003576 tRNA binding surface [nucleotide binding]; other site 357244003577 anticodon binding site; other site 357244003578 primosome assembly protein PriA; Validated; Region: PRK05580 357244003579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357244003580 ATP binding site [chemical binding]; other site 357244003581 putative Mg++ binding site [ion binding]; other site 357244003582 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357244003583 helicase superfamily c-terminal domain; Region: HELICc; smart00490 357244003584 type IV secretion system protein VirB3; Provisional; Region: PRK13899 357244003585 type IV secretion system ATPase VirB4; Provisional; Region: PRK13898 357244003586 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 357244003587 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357244003588 Walker A/P-loop; other site 357244003589 ATP binding site [chemical binding]; other site 357244003590 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 357244003591 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 357244003592 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 357244003593 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 357244003594 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 357244003595 metabolite-proton symporter; Region: 2A0106; TIGR00883 357244003596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357244003597 putative substrate translocation pore; other site 357244003598 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 357244003599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003600 ATP binding site [chemical binding]; other site 357244003601 Mg2+ binding site [ion binding]; other site 357244003602 G-X-G motif; other site 357244003603 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 357244003604 ATP binding site [chemical binding]; other site 357244003605 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 357244003606 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 357244003607 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357244003608 active site 357244003609 HIGH motif; other site 357244003610 nucleotide binding site [chemical binding]; other site 357244003611 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357244003612 active site 357244003613 KMSKS motif; other site 357244003614 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 357244003615 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357244003616 active site 357244003617 HIGH motif; other site 357244003618 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357244003619 KMSKS motif; other site 357244003620 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 357244003621 tRNA binding surface [nucleotide binding]; other site 357244003622 anticodon binding site; other site 357244003623 conserved hypothetical protein 357244003624 transposase and inactivated derivative 357244003625 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 357244003626 Part of AAA domain; Region: AAA_19; pfam13245 357244003627 Family description; Region: UvrD_C_2; pfam13538 357244003628 transposase and inactivated derivative 357244003629 transposase and inactivated derivative 357244003630 conserved hypothetical protein 357244003631 transposase and inactivated derivative 357244003632 transposase and inactivated derivative 357244003633 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 357244003634 PLD-like domain; Region: PLDc_2; pfam13091 357244003635 putative active site [active] 357244003636 catalytic site [active] 357244003637 transposase and inactivated derivative 357244003638 conjugative transfer protein 357244003639 hypothetical protein 357244003640 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003641 HD domain; Region: HD_4; pfam13328 357244003642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003644 ATP binding site [chemical binding]; other site 357244003645 Mg2+ binding site [ion binding]; other site 357244003646 G-X-G motif; other site 357244003647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003648 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244003649 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244003650 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003651 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003652 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003653 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 357244003654 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244003655 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244003656 conserved hypothetical protein 357244003657 leucine-rich repeat protein 357244003658 phage-related integrase 357244003659 transposase and inactivated derivative 357244003660 transposase and inactivated derivative 357244003661 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003662 active site 357244003663 Int/Topo IB signature motif; other site 357244003664 DNA binding site [nucleotide binding] 357244003665 TraE protein; Region: TraE; cl05060 357244003666 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244003667 conjugative transfer protein 357244003668 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244003669 conjugative transfer protein 357244003670 ankyrin repeat protein with 8 ankyrin repeats 357244003671 conjugative pilus assembly protein 357244003672 conjugative pilus assembly protein 357244003673 conjugative transfer protein 357244003674 TPR repeat; Region: TPR_11; pfam13414 357244003675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003676 binding surface 357244003677 TPR motif; other site 357244003678 TPR repeat; Region: TPR_11; pfam13414 357244003679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003680 binding surface 357244003681 TPR repeat; Region: TPR_11; pfam13414 357244003682 TPR motif; other site 357244003683 TPR repeat; Region: TPR_11; pfam13414 357244003684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003685 binding surface 357244003686 TPR motif; other site 357244003687 TPR repeat; Region: TPR_11; pfam13414 357244003688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003689 binding surface 357244003690 TPR motif; other site 357244003691 conjugative transfer protein 357244003692 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244003693 conjugative transfer protein 357244003694 Conjugal transfer protein TraD; Region: TraD; pfam06412 357244003695 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003696 HD domain; Region: HD_4; pfam13328 357244003697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003699 ATP binding site [chemical binding]; other site 357244003700 Mg2+ binding site [ion binding]; other site 357244003701 G-X-G motif; other site 357244003702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003703 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003704 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003705 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357244003706 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357244003707 transposase and inactivated derivative 357244003708 conserved hypothetical protein 357244003709 transposase and inactivated derivative 357244003710 transposase and inactivated derivative 357244003711 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003712 active site 357244003713 Int/Topo IB signature motif; other site 357244003714 DNA binding site [nucleotide binding] 357244003715 TraE protein; Region: TraE; cl05060 357244003716 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244003717 conjugative transfer protein 357244003718 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244003719 conjugative transfer protein 357244003720 conjugative pilus assembly protein 357244003721 conjugative pilus assembly protein 357244003722 conjugative transfer protein 357244003723 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 357244003724 transposase and inactivated derivative 357244003725 conjugative transfer protein 357244003726 transposase and inactivated derivative 357244003727 conjugative transfer protein 357244003728 conjugative transfer protein 357244003729 conserved hypothetical protein 357244003730 transposase and inactivated derivative 357244003731 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 357244003732 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 357244003733 conserved hypothetical protein 357244003734 replicative DNA helicase 357244003735 spoT-like ppGpp hydrolase 357244003736 submitted as non-pseudo;site-specific DNA adenine methylase 357244003737 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003738 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357244003739 Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441 357244003740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003741 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357244003742 signal transduction histidine kinase 357244003743 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003744 HD domain; Region: HD_4; pfam13328 357244003745 conjugative transfer protein 357244003746 transposase and inactivated derivative 357244003747 conjugative transfer protein 357244003748 putative transposase; Provisional; Region: PRK09857 357244003749 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 357244003750 conjugative transfer protein 357244003751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003752 TPR motif; other site 357244003753 TPR repeat; Region: TPR_11; pfam13414 357244003754 binding surface 357244003755 TPR repeat; Region: TPR_11; pfam13414 357244003756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003757 binding surface 357244003758 TPR motif; other site 357244003759 TPR repeat; Region: TPR_11; pfam13414 357244003760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357244003761 binding surface 357244003762 TPR motif; other site 357244003763 conjugative transfer protein 357244003764 conjugative pilus assembly protein 357244003765 conjugative pilus assembly protein 357244003766 Type-1V conjugative transfer system mating pair stabilisation; Region: TraN; pfam06986 357244003767 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 357244003768 conjugative transfer protein 357244003769 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 357244003770 conjugative transfer protein 357244003771 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 357244003772 conjugative transfer protein 357244003773 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 357244003774 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003775 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 357244003776 active site 357244003777 DNA binding site [nucleotide binding] 357244003778 Int/Topo IB signature motif; other site 357244003779 transposase and inactivated derivative 357244003780 replicative DNA helicase 357244003781 conserved hypothetical protein 357244003782 replicative DNA helicase 357244003783 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357244003784 HD domain; Region: HD_4; pfam13328 357244003785 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 357244003786 Protein of unknown function (DUF2748); Region: DUF2748; pfam10871 357244003787 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 357244003788 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 357244003789 Ligand Binding Site [chemical binding]; other site 357244003790 propionyl-CoA carboxylase beta chain precursor 357244003791 transposase and inactivated derivative 357244003792 conserved hypothetical protein 357244003793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357244003794 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357244003795 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357244003796 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003797 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 357244003798 site-specific DNA adenine methylase 357244003799 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 357244003800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003801 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357244003802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357244003803 ATP binding site [chemical binding]; other site 357244003804 Mg2+ binding site [ion binding]; other site 357244003805 G-X-G motif; other site 357244003806 spoT-like ppGpp hydrolase 357244003807 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 357244003808 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357244003809 submitted as non-pseudo;conserved hypothetical protein 357244003810 transposase and inactivated derivative 357244003811 conjugative transfer protein 357244003812 conjugative transfer protein 357244003813 RNA-directed DNA polymerase (Reverse transcriptase) 357244003814 conjugative transfer protein 357244003815 conjugative transfer protein 357244003816 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 357244003817 putative catalytic site [active] 357244003818 putative phosphate binding site [ion binding]; other site 357244003819 active site 357244003820 metal binding site A [ion binding]; metal-binding site 357244003821 DNA binding site [nucleotide binding] 357244003822 putative AP binding site [nucleotide binding]; other site 357244003823 putative metal binding site B [ion binding]; other site 357244003824 spoT-like ppGpp hydrolase 357244003825 transposase and inactivated derivative 357244003826 hypothetical protein 357244003827 replicative DNA helicase 357244003828 transposase and inactivated derivative 357244003829 conjugative transfer protein 357244003830 transposase and inactivated derivative 357244003831 transposase and inactivated derivative 357244003832 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357244003833 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357244003834 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357244003835 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357244003836 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357244003837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357244003838 conserved hypothetical protein 357244003839 Autotransporter beta-domain; Region: Autotransporter; smart00869 357244003840 transposase and inactivated derivative 357244003841 transposase and inactivated derivative 357244003842 transposase and inactivated derivative 357244003843 transposase and inactivated derivative 357244003844 transposase and inactivated derivative 357244003845 transposase and inactivated derivative 357244003846 transposase and inactivated derivative 357244003847 transposase and inactivated derivative 357244003848 phenylalanyl-tRNA synthetase alpha chain 357244003849 transposase and inactivated derivative 357244003850 Autotransporter beta-domain; Region: Autotransporter; smart00869 357244003851 transposase and inactivated derivative 357244003852 RNA-directed DNA polymerase (Reverse transcriptase) 357244003853 submitted as non-pseudo;hypothetical protein 357244003854 hypothetical protein 357244003855 transposase and inactivated derivative 357244003856 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357244003857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357244003858 RNA binding surface [nucleotide binding]; other site 357244003859 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357244003860 active site 357244003861 DNA polymerase III subunit delta'; Validated; Region: PRK06581 357244003862 DNA polymerase III subunit delta'; Validated; Region: PRK08485 357244003863 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 357244003864 dimer interface [polypeptide binding]; other site 357244003865 substrate binding site [chemical binding]; other site 357244003866 metal binding sites [ion binding]; metal-binding site 357244003867 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 357244003868 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 357244003869 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357244003870 active site 357244003871 DNA binding site [nucleotide binding] 357244003872 Int/Topo IB signature motif; other site 357244003873 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 357244003874 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 357244003875 trmE is a tRNA modification GTPase; Region: trmE; cd04164 357244003876 G1 box; other site 357244003877 GTP/Mg2+ binding site [chemical binding]; other site 357244003878 Switch I region; other site 357244003879 G2 box; other site 357244003880 Switch II region; other site 357244003881 G3 box; other site 357244003882 G4 box; other site 357244003883 G5 box; other site 357244003884 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 357244003885 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 357244003886 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 357244003887 transposase and inactivated derivative 357244003888 transposase and inactivated derivative 357244003889 transposase and inactivated derivative 357244003890 transposase and inactivated derivative 357244003891 Preprotein translocase subunit SecB; Region: SecB; pfam02556 357244003892 SecA binding site; other site 357244003893 Preprotein binding site; other site 357244003894 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 357244003895 trimer interface [polypeptide binding]; other site 357244003896 active site 357244003897 Gram-negative porin; Region: Porin_4; pfam13609 357244003898 Ribosome recycling factor [Translation, ribosomal structure and biogenesis]; Region: Frr; COG0233 357244003899 ribosome recycling factor; Reviewed; Region: frr; PRK00083 357244003900 hinge region; other site 357244003901 NADH dehydrogenase subunit G; Validated; Region: PRK09130 357244003902 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357244003903 catalytic loop [active] 357244003904 iron binding site [ion binding]; other site 357244003905 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 357244003906 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357244003907 molybdopterin cofactor binding site; other site 357244003908 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 357244003909 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 357244003910 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 357244003911 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 357244003912 4Fe-4S binding domain; Region: Fer4; pfam00037 357244003913 4Fe-4S binding domain; Region: Fer4; pfam00037 357244003914 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 357244003915 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 357244003916 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 357244003917 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 357244003918 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 357244003919 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 357244003920 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357244003921 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 357244003922 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357244003923 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 357244003924 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357244003925 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 357244003926 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 357244003927 Ligand Binding Site [chemical binding]; other site 357244003928 FtsH Extracellular; Region: FtsH_ext; pfam06480 357244003929 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 357244003930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357244003931 Walker A motif; other site 357244003932 ATP binding site [chemical binding]; other site 357244003933 Walker B motif; other site 357244003934 arginine finger; other site 357244003935 Peptidase family M41; Region: Peptidase_M41; pfam01434 357244003936 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 357244003937 active site 357244003938 DNA binding site [nucleotide binding] 357244003939 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 357244003940 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 357244003941 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 357244003942 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357244003943 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357244003944 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 357244003945 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 357244003946 hypothetical protein 357244003947 conjugative transfer protein 357244003948 ankyrin repeat protein; Provisional; Region: PHA03100 357244003949 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003950 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357244003951 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110