-- dump date 20140619_165640 -- class Genbank::misc_feature -- table misc_feature_note -- id note 63737000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 63737000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 63737000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737000004 Walker A motif; other site 63737000005 ATP binding site [chemical binding]; other site 63737000006 Walker B motif; other site 63737000007 arginine finger; other site 63737000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 63737000009 DnaA box-binding interface [nucleotide binding]; other site 63737000010 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737000011 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 63737000012 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 63737000013 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737000014 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737000015 homodimer interface [polypeptide binding]; other site 63737000016 catalytic residue [active] 63737000017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 63737000018 AAA ATPase domain; Region: AAA_16; pfam13191 63737000019 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737000020 WD40 repeats; Region: WD40; smart00320 63737000021 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000022 structural tetrad; other site 63737000023 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737000024 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000025 structural tetrad; other site 63737000026 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737000027 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000028 structural tetrad; other site 63737000029 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 63737000030 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 63737000031 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 63737000032 catalytic motif [active] 63737000033 Zn binding site [ion binding]; other site 63737000034 RibD C-terminal domain; Region: RibD_C; cl17279 63737000035 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 63737000036 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737000037 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737000038 active site 63737000039 ATP binding site [chemical binding]; other site 63737000040 substrate binding site [chemical binding]; other site 63737000041 activation loop (A-loop); other site 63737000042 tellurium resistance terB-like protein; Region: terB_like; cl11965 63737000043 metal binding site [ion binding]; metal-binding site 63737000044 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 63737000045 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 63737000046 active site 63737000047 catalytic site [active] 63737000048 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 63737000049 starch-binding site 2 [chemical binding]; other site 63737000050 starch-binding site 1 [chemical binding]; other site 63737000051 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737000052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737000053 S-adenosylmethionine binding site [chemical binding]; other site 63737000054 phosphoenolpyruvate synthase; Validated; Region: PRK06464 63737000055 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 63737000056 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 63737000057 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 63737000058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 63737000059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 63737000060 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 63737000061 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 63737000062 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737000063 Phytochrome region; Region: PHY; pfam00360 63737000064 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737000065 dimer interface [polypeptide binding]; other site 63737000066 phosphorylation site [posttranslational modification] 63737000067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737000068 ATP binding site [chemical binding]; other site 63737000069 Mg2+ binding site [ion binding]; other site 63737000070 G-X-G motif; other site 63737000071 Response regulator receiver domain; Region: Response_reg; pfam00072 63737000072 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737000073 active site 63737000074 phosphorylation site [posttranslational modification] 63737000075 intermolecular recognition site; other site 63737000076 dimerization interface [polypeptide binding]; other site 63737000077 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737000078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737000079 active site 63737000080 phosphorylation site [posttranslational modification] 63737000081 intermolecular recognition site; other site 63737000082 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737000083 dimerization interface [polypeptide binding]; other site 63737000084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737000085 dimer interface [polypeptide binding]; other site 63737000086 phosphorylation site [posttranslational modification] 63737000087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737000088 ATP binding site [chemical binding]; other site 63737000089 Mg2+ binding site [ion binding]; other site 63737000090 G-X-G motif; other site 63737000091 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 63737000092 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737000093 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000094 DNA gyrase subunit A; Validated; Region: PRK05560 63737000095 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 63737000096 CAP-like domain; other site 63737000097 active site 63737000098 primary dimer interface [polypeptide binding]; other site 63737000099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737000100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737000101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737000102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737000103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737000104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737000105 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 63737000106 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 63737000107 putative active site [active] 63737000108 catalytic triad [active] 63737000109 putative dimer interface [polypeptide binding]; other site 63737000110 Tic20-like protein; Region: Tic20; pfam09685 63737000111 transaldolase-like protein; Provisional; Region: PTZ00411 63737000112 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 63737000113 active site 63737000114 dimer interface [polypeptide binding]; other site 63737000115 catalytic residue [active] 63737000116 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 63737000117 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 63737000118 domain interfaces; other site 63737000119 active site 63737000120 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 63737000121 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 63737000122 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 63737000123 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 63737000124 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 63737000125 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 63737000126 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 63737000127 DNA polymerase III subunit beta; Validated; Region: PRK05643 63737000128 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 63737000129 putative DNA binding surface [nucleotide binding]; other site 63737000130 dimer interface [polypeptide binding]; other site 63737000131 beta-clamp/clamp loader binding surface; other site 63737000132 beta-clamp/translesion DNA polymerase binding surface; other site 63737000133 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 63737000134 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 63737000135 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737000136 classical (c) SDRs; Region: SDR_c; cd05233 63737000137 NAD(P) binding site [chemical binding]; other site 63737000138 active site 63737000139 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737000140 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 63737000141 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 63737000142 putative NAD(P) binding site [chemical binding]; other site 63737000143 active site 63737000144 putative substrate binding site [chemical binding]; other site 63737000145 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 63737000146 FMN binding site [chemical binding]; other site 63737000147 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 63737000148 substrate binding site [chemical binding]; other site 63737000149 putative catalytic residue [active] 63737000150 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737000151 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 63737000152 active site 63737000153 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737000154 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 63737000155 active site 63737000156 Acyl transferase domain; Region: Acyl_transf_1; cl08282 63737000157 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737000158 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 63737000159 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737000160 putative NADP binding site [chemical binding]; other site 63737000161 active site 63737000162 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737000163 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737000164 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 63737000165 active site 63737000166 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 63737000167 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737000168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737000169 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737000170 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737000171 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737000172 DevC protein; Region: devC; TIGR01185 63737000173 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737000174 FtsX-like permease family; Region: FtsX; pfam02687 63737000175 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737000176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737000177 NAD(P) binding site [chemical binding]; other site 63737000178 active site 63737000179 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000180 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 63737000181 active site 63737000182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 63737000183 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 63737000184 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737000185 active site 63737000186 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737000187 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 63737000188 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 63737000189 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 63737000190 catalytic residues [active] 63737000191 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 63737000192 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 63737000193 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 63737000194 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 63737000195 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 63737000196 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 63737000197 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 63737000198 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 63737000199 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 63737000200 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 63737000201 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737000202 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 63737000203 Lumazine binding domain; Region: Lum_binding; pfam00677 63737000204 Lumazine binding domain; Region: Lum_binding; pfam00677 63737000205 Bifunctional nuclease; Region: DNase-RNase; pfam02577 63737000206 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 63737000207 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737000208 active site 63737000209 catalytic tetrad [active] 63737000210 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737000211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737000212 Walker A/P-loop; other site 63737000213 ATP binding site [chemical binding]; other site 63737000214 Q-loop/lid; other site 63737000215 ABC transporter signature motif; other site 63737000216 Walker B; other site 63737000217 D-loop; other site 63737000218 H-loop/switch region; other site 63737000219 Protein of unknown function, DUF488; Region: DUF488; pfam04343 63737000220 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 63737000221 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 63737000222 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 63737000223 substrate binding pocket [chemical binding]; other site 63737000224 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 63737000225 B12 binding site [chemical binding]; other site 63737000226 cobalt ligand [ion binding]; other site 63737000227 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 63737000228 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 63737000229 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 63737000230 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 63737000231 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737000233 active site 63737000234 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737000236 active site 63737000237 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000238 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737000239 active site 63737000240 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 63737000241 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 63737000242 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737000243 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737000244 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 63737000245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737000246 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 63737000247 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 63737000248 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000249 putative metal binding site; other site 63737000250 Uncharacterized conserved protein [Function unknown]; Region: COG2928 63737000251 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 63737000252 putative RNA binding site [nucleotide binding]; other site 63737000253 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 63737000254 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 63737000255 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 63737000256 P loop; other site 63737000257 GTP binding site [chemical binding]; other site 63737000258 GAF domain; Region: GAF_3; pfam13492 63737000259 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 63737000260 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 63737000261 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 63737000262 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 63737000263 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 63737000264 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 63737000265 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 63737000266 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 63737000267 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 63737000268 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 63737000269 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 63737000270 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 63737000271 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 63737000272 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 63737000273 NADH(P)-binding; Region: NAD_binding_10; pfam13460 63737000274 NAD(P) binding site [chemical binding]; other site 63737000275 putative active site [active] 63737000276 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 63737000277 N-acetyl-D-glucosamine binding site [chemical binding]; other site 63737000278 catalytic residue [active] 63737000279 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 63737000280 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 63737000281 putative homodimer interface [polypeptide binding]; other site 63737000282 putative homotetramer interface [polypeptide binding]; other site 63737000283 putative metal binding site [ion binding]; other site 63737000284 putative homodimer-homodimer interface [polypeptide binding]; other site 63737000285 putative allosteric switch controlling residues; other site 63737000286 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 63737000287 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 63737000288 Uncharacterized conserved protein [Function unknown]; Region: COG1432 63737000289 LabA_like proteins; Region: LabA; cd10911 63737000290 putative metal binding site [ion binding]; other site 63737000291 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 63737000292 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 63737000293 active site 63737000294 HIGH motif; other site 63737000295 KMSKS motif; other site 63737000296 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 63737000297 anticodon binding site; other site 63737000298 tRNA binding surface [nucleotide binding]; other site 63737000299 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 63737000300 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 63737000301 putative acyl-acceptor binding pocket; other site 63737000302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737000303 multifunctional aminopeptidase A; Provisional; Region: PRK00913 63737000304 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 63737000305 interface (dimer of trimers) [polypeptide binding]; other site 63737000306 Substrate-binding/catalytic site; other site 63737000307 Zn-binding sites [ion binding]; other site 63737000308 putative phosphate acyltransferase; Provisional; Region: PRK05331 63737000309 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 63737000310 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 63737000311 dimer interface [polypeptide binding]; other site 63737000312 active site 63737000313 CoA binding pocket [chemical binding]; other site 63737000314 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 63737000315 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737000316 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 63737000317 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 63737000318 putative acyl-acceptor binding pocket; other site 63737000319 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737000320 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737000321 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 63737000322 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 63737000323 MutS domain III; Region: MutS_III; pfam05192 63737000324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737000325 Walker A/P-loop; other site 63737000326 ATP binding site [chemical binding]; other site 63737000327 Q-loop/lid; other site 63737000328 ABC transporter signature motif; other site 63737000329 Walker B; other site 63737000330 D-loop; other site 63737000331 H-loop/switch region; other site 63737000332 Smr domain; Region: Smr; pfam01713 63737000333 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 63737000334 molybdate ABC transporter periplasmic molybdate-binding protein; Provisional; Region: PRK03537 63737000335 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 63737000336 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 63737000337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298 63737000338 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 63737000339 Ycf35; Provisional; Region: ycf35; CHL00193 63737000340 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 63737000341 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 63737000342 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 63737000343 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 63737000344 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 63737000345 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 63737000346 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 63737000347 Walker A motif; other site 63737000348 ATP binding site [chemical binding]; other site 63737000349 Walker B motif; other site 63737000350 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 63737000351 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 63737000352 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 63737000353 Walker A motif; other site 63737000354 ATP binding site [chemical binding]; other site 63737000355 Walker B motif; other site 63737000356 GrpE; Region: GrpE; pfam01025 63737000357 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 63737000358 dimer interface [polypeptide binding]; other site 63737000359 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 63737000360 molecular chaperone DnaK; Provisional; Region: PRK13411 63737000361 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 63737000362 nucleotide binding site [chemical binding]; other site 63737000363 NEF interaction site [polypeptide binding]; other site 63737000364 SBD interface [polypeptide binding]; other site 63737000365 chaperone protein DnaJ; Provisional; Region: PRK14293 63737000366 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737000367 HSP70 interaction site [polypeptide binding]; other site 63737000368 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 63737000369 Zn binding sites [ion binding]; other site 63737000370 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 63737000371 dimer interface [polypeptide binding]; other site 63737000372 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 63737000373 CPxP motif; other site 63737000374 GTPase RsgA; Reviewed; Region: PRK12289 63737000375 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 63737000376 RNA binding site [nucleotide binding]; other site 63737000377 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 63737000378 GTPase/Zn-binding domain interface [polypeptide binding]; other site 63737000379 GTP/Mg2+ binding site [chemical binding]; other site 63737000380 G4 box; other site 63737000381 G5 box; other site 63737000382 G1 box; other site 63737000383 Switch I region; other site 63737000384 G2 box; other site 63737000385 G3 box; other site 63737000386 Switch II region; other site 63737000387 Uncharacterized conserved protein [Function unknown]; Region: COG1543 63737000388 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 63737000389 active site 63737000390 substrate binding site [chemical binding]; other site 63737000391 catalytic site [active] 63737000392 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 63737000393 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737000394 putative active site [active] 63737000395 Cupin domain; Region: Cupin_2; pfam07883 63737000396 cytochrome f; Region: petA; CHL00037 63737000397 apocytochrome f; Reviewed; Region: PRK02693 63737000398 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 63737000399 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 63737000400 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 63737000401 cytochrome b subunit interaction site [polypeptide binding]; other site 63737000402 [2Fe-2S] cluster binding site [ion binding]; other site 63737000403 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 63737000404 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 63737000405 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 63737000406 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 63737000407 dimer interface [polypeptide binding]; other site 63737000408 putative tRNA-binding site [nucleotide binding]; other site 63737000409 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 63737000410 short chain dehydrogenase; Validated; Region: PRK06182 63737000411 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 63737000412 NADP binding site [chemical binding]; other site 63737000413 active site 63737000414 steroid binding site; other site 63737000415 AAA ATPase domain; Region: AAA_16; pfam13191 63737000416 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 63737000417 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000418 structural tetrad; other site 63737000419 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737000420 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000421 structural tetrad; other site 63737000422 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000423 structural tetrad; other site 63737000424 Protein of unknown function DUF262; Region: DUF262; pfam03235 63737000425 Uncharacterized conserved protein [Function unknown]; Region: COG1479 63737000426 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737000427 putative active site [active] 63737000428 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 63737000429 non-specific DNA binding site [nucleotide binding]; other site 63737000430 salt bridge; other site 63737000431 sequence-specific DNA binding site [nucleotide binding]; other site 63737000432 Phage-related protein [Function unknown]; Region: COG4679 63737000433 Protein of unknown function (DUF433); Region: DUF433; cl01030 63737000434 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 63737000435 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737000436 HSP70 interaction site [polypeptide binding]; other site 63737000437 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737000438 TPR repeat; Region: TPR_11; pfam13414 63737000439 binding surface 63737000440 TPR motif; other site 63737000441 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737000442 HSP70 interaction site [polypeptide binding]; other site 63737000443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737000444 TPR repeat; Region: TPR_11; pfam13414 63737000445 binding surface 63737000446 TPR motif; other site 63737000447 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737000448 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000449 structural tetrad; other site 63737000450 phosphodiesterase YaeI; Provisional; Region: PRK11340 63737000451 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 63737000452 putative active site [active] 63737000453 putative metal binding site [ion binding]; other site 63737000454 phosphodiesterase YaeI; Provisional; Region: PRK11340 63737000455 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 63737000456 putative active site [active] 63737000457 putative metal binding site [ion binding]; other site 63737000458 Protein of unknown function DUF262; Region: DUF262; pfam03235 63737000459 Uncharacterized conserved protein [Function unknown]; Region: COG1479 63737000460 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 63737000461 Winged helix-turn helix; Region: HTH_29; pfam13551 63737000462 Homeodomain-like domain; Region: HTH_23; pfam13384 63737000463 Homeodomain-like domain; Region: HTH_32; pfam13565 63737000464 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737000465 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737000466 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 63737000467 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 63737000468 substrate binding site [chemical binding]; other site 63737000469 ligand binding site [chemical binding]; other site 63737000470 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 63737000471 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 63737000472 substrate binding site [chemical binding]; other site 63737000473 glycogen branching enzyme; Provisional; Region: PRK05402 63737000474 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 63737000475 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 63737000476 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 63737000477 active site 63737000478 catalytic site [active] 63737000479 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 63737000480 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 63737000481 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 63737000482 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737000483 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 63737000484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737000485 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 63737000486 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 63737000487 putative active site [active] 63737000488 catalytic site [active] 63737000489 putative metal binding site [ion binding]; other site 63737000490 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 63737000491 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 63737000492 nucleotide binding pocket [chemical binding]; other site 63737000493 K-X-D-G motif; other site 63737000494 catalytic site [active] 63737000495 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 63737000496 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 63737000497 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 63737000498 Dimer interface [polypeptide binding]; other site 63737000499 Winged helix-turn helix; Region: HTH_29; pfam13551 63737000500 Homeodomain-like domain; Region: HTH_23; pfam13384 63737000501 Homeodomain-like domain; Region: HTH_32; pfam13565 63737000502 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737000503 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737000504 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737000505 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737000506 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737000507 GAF domain; Region: GAF; pfam01590 63737000508 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737000509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737000510 metal binding site [ion binding]; metal-binding site 63737000511 active site 63737000512 I-site; other site 63737000513 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737000514 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737000515 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737000516 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737000517 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000518 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 63737000519 putative metal binding site; other site 63737000520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737000521 TPR motif; other site 63737000522 binding surface 63737000523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737000524 binding surface 63737000525 TPR repeat; Region: TPR_11; pfam13414 63737000526 TPR motif; other site 63737000527 TPR repeat; Region: TPR_11; pfam13414 63737000528 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 63737000529 aspartate aminotransferase; Provisional; Region: PRK05764 63737000530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737000531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737000532 homodimer interface [polypeptide binding]; other site 63737000533 catalytic residue [active] 63737000534 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 63737000535 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 63737000536 putative active site; other site 63737000537 catalytic residue [active] 63737000538 Peptidase family M48; Region: Peptidase_M48; cl12018 63737000539 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 63737000540 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737000541 catalytic residues [active] 63737000542 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 63737000543 proposed catalytic triad [active] 63737000544 active site nucleophile [active] 63737000545 Protein of unknown function (DUF1392); Region: DUF1392; pfam07154 63737000546 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 63737000547 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 63737000548 putative dimer interface [polypeptide binding]; other site 63737000549 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737000550 classical (c) SDRs; Region: SDR_c; cd05233 63737000551 NAD(P) binding site [chemical binding]; other site 63737000552 active site 63737000553 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 63737000554 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 63737000555 substrate binding site [chemical binding]; other site 63737000556 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737000557 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000558 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000559 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737000560 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000561 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000562 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 63737000563 short chain dehydrogenase; Provisional; Region: PRK06701 63737000564 NAD binding site [chemical binding]; other site 63737000565 metal binding site [ion binding]; metal-binding site 63737000566 active site 63737000567 short chain dehydrogenase; Provisional; Region: PRK07109 63737000568 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 63737000569 putative NAD(P) binding site [chemical binding]; other site 63737000570 active site 63737000571 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 63737000572 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 63737000573 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 63737000574 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 63737000575 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 63737000576 dimer interface [polypeptide binding]; other site 63737000577 active site 63737000578 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 63737000579 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 63737000580 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 63737000581 active site 63737000582 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 63737000583 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 63737000584 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 63737000585 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 63737000586 Cupin domain; Region: Cupin_2; cl17218 63737000587 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 63737000588 Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991 63737000589 active site 63737000590 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 63737000591 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 63737000592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737000593 putative homodimer interface [polypeptide binding]; other site 63737000594 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 63737000595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737000596 UDP-galactopyranose mutase; Region: GLF; pfam03275 63737000597 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 63737000598 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 63737000599 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 63737000600 NADP binding site [chemical binding]; other site 63737000601 active site 63737000602 putative substrate binding site [chemical binding]; other site 63737000603 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 63737000604 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 63737000605 NAD binding site [chemical binding]; other site 63737000606 homodimer interface [polypeptide binding]; other site 63737000607 active site 63737000608 substrate binding site [chemical binding]; other site 63737000609 UV damage repair endonuclease [DNA replication, recombination, and repair]; Region: Uve; COG4294 63737000610 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 63737000611 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 63737000612 HflX GTPase family; Region: HflX; cd01878 63737000613 G1 box; other site 63737000614 GTP/Mg2+ binding site [chemical binding]; other site 63737000615 Switch I region; other site 63737000616 G2 box; other site 63737000617 G3 box; other site 63737000618 Switch II region; other site 63737000619 G4 box; other site 63737000620 G5 box; other site 63737000621 ASRGL1_like domains, a subfamily of the L-Asparaginase type 2-like enzymes. The wider family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. The proenzymes undergo autoproteolytic cleavage before a threonine to generate alpha...; Region: ASRGL1_like; cd04702 63737000622 catalytic nucleophile [active] 63737000623 Protein of unknown function DUF72; Region: DUF72; pfam01904 63737000624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737000625 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 63737000626 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 63737000627 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 63737000628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737000629 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 63737000630 short chain dehydrogenase; Provisional; Region: PRK07109 63737000631 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 63737000632 putative NAD(P) binding site [chemical binding]; other site 63737000633 active site 63737000634 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 63737000635 dimanganese center [ion binding]; other site 63737000636 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 63737000637 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 63737000638 putative active site [active] 63737000639 putative dimer interface [polypeptide binding]; other site 63737000640 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 63737000641 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 63737000642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737000643 O-methyltransferase; Region: Methyltransf_2; pfam00891 63737000644 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737000645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737000646 Coenzyme A binding pocket [chemical binding]; other site 63737000647 SdiA-regulated; Region: SdiA-regulated; cd09971 63737000648 putative active site [active] 63737000649 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737000650 Ligand Binding Site [chemical binding]; other site 63737000651 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 63737000652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737000653 active site 63737000654 phosphorylation site [posttranslational modification] 63737000655 intermolecular recognition site; other site 63737000656 CheB methylesterase; Region: CheB_methylest; pfam01339 63737000657 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737000658 putative binding surface; other site 63737000659 active site 63737000660 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 63737000661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737000662 ATP binding site [chemical binding]; other site 63737000663 Mg2+ binding site [ion binding]; other site 63737000664 G-X-G motif; other site 63737000665 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 63737000666 Response regulator receiver domain; Region: Response_reg; pfam00072 63737000667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737000668 active site 63737000669 phosphorylation site [posttranslational modification] 63737000670 intermolecular recognition site; other site 63737000671 dimerization interface [polypeptide binding]; other site 63737000672 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 63737000673 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 63737000674 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 63737000675 HAMP domain; Region: HAMP; pfam00672 63737000676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737000677 dimer interface [polypeptide binding]; other site 63737000678 putative CheW interface [polypeptide binding]; other site 63737000679 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 63737000680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737000681 S-adenosylmethionine binding site [chemical binding]; other site 63737000682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737000683 binding surface 63737000684 TPR motif; other site 63737000685 TPR repeat; Region: TPR_11; pfam13414 63737000686 CHASE3 domain; Region: CHASE3; cl05000 63737000687 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 63737000688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737000689 dimerization interface [polypeptide binding]; other site 63737000690 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 63737000691 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737000692 dimer interface [polypeptide binding]; other site 63737000693 putative CheW interface [polypeptide binding]; other site 63737000694 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 63737000695 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 63737000696 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 63737000697 Cation transporter family protein; Region: LIC; TIGR00860 63737000698 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 63737000699 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 63737000700 NADP binding site [chemical binding]; other site 63737000701 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 63737000702 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 63737000703 glycogen binding site [chemical binding]; other site 63737000704 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 63737000705 active site 63737000706 catalytic site [active] 63737000707 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 63737000708 proton extrusion protein PcxA; Provisional; Region: PRK02507 63737000709 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 63737000710 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 63737000711 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 63737000712 CheB methylesterase; Region: CheB_methylest; pfam01339 63737000713 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 63737000714 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 63737000715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737000716 S-adenosylmethionine binding site [chemical binding]; other site 63737000717 PAS fold; Region: PAS_4; pfam08448 63737000718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737000719 putative active site [active] 63737000720 heme pocket [chemical binding]; other site 63737000721 PAS domain S-box; Region: sensory_box; TIGR00229 63737000722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737000723 putative active site [active] 63737000724 heme pocket [chemical binding]; other site 63737000725 AAA ATPase domain; Region: AAA_16; pfam13191 63737000726 WD domain, G-beta repeat; Region: WD40; pfam00400 63737000727 PQQ-like domain; Region: PQQ_2; pfam13360 63737000728 WD40 repeats; Region: WD40; smart00320 63737000729 WD40 repeats; Region: WD40; smart00320 63737000730 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000731 structural tetrad; other site 63737000732 AAA ATPase domain; Region: AAA_16; pfam13191 63737000733 NACHT domain; Region: NACHT; pfam05729 63737000734 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 63737000735 active site 63737000736 dinuclear metal binding site [ion binding]; other site 63737000737 dimerization interface [polypeptide binding]; other site 63737000738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737000739 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737000740 active site 63737000741 metal binding site [ion binding]; metal-binding site 63737000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737000743 Coenzyme A binding pocket [chemical binding]; other site 63737000744 comF family protein; Region: comF; TIGR00201 63737000745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737000746 active site 63737000747 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 63737000748 cobalamin synthase; Reviewed; Region: cobS; PRK00235 63737000749 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 63737000750 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 63737000751 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737000752 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 63737000753 catalytic loop [active] 63737000754 iron binding site [ion binding]; other site 63737000755 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 63737000756 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737000757 Ligand Binding Site [chemical binding]; other site 63737000758 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737000759 Ligand Binding Site [chemical binding]; other site 63737000760 PhoD-like phosphatase; Region: PhoD; pfam09423 63737000761 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 63737000762 putative active site [active] 63737000763 putative metal binding site [ion binding]; other site 63737000764 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 63737000765 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 63737000766 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 63737000767 putative catalytic cysteine [active] 63737000768 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 63737000769 homopentamer interface [polypeptide binding]; other site 63737000770 active site 63737000771 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 63737000772 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 63737000773 DHH family; Region: DHH; pfam01368 63737000774 FOG: CBS domain [General function prediction only]; Region: COG0517 63737000775 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 63737000776 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 63737000777 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 63737000778 active site 63737000779 NTP binding site [chemical binding]; other site 63737000780 metal binding triad [ion binding]; metal-binding site 63737000781 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 63737000782 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737000783 putative active site [active] 63737000784 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 63737000785 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 63737000786 ABC transporter; Region: ABC_tran_2; pfam12848 63737000787 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 63737000788 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 63737000789 ABC1 family; Region: ABC1; cl17513 63737000790 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 63737000791 active site 63737000792 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 63737000793 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737000794 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737000795 active site 63737000796 ATP binding site [chemical binding]; other site 63737000797 substrate binding site [chemical binding]; other site 63737000798 activation loop (A-loop); other site 63737000799 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737000800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737000801 active site 63737000802 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 63737000803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737000804 BT1 family; Region: BT1; pfam03092 63737000805 putative substrate translocation pore; other site 63737000806 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 63737000807 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 63737000808 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 63737000809 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 63737000810 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 63737000811 Ligand Binding Site [chemical binding]; other site 63737000812 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 63737000813 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 63737000814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737000815 Soluble P-type ATPase [General function prediction only]; Region: COG4087 63737000816 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 63737000817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737000818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737000819 dimer interface [polypeptide binding]; other site 63737000820 phosphorylation site [posttranslational modification] 63737000821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737000822 ATP binding site [chemical binding]; other site 63737000823 Mg2+ binding site [ion binding]; other site 63737000824 G-X-G motif; other site 63737000825 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737000826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737000827 active site 63737000828 phosphorylation site [posttranslational modification] 63737000829 intermolecular recognition site; other site 63737000830 dimerization interface [polypeptide binding]; other site 63737000831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737000832 DNA binding residues [nucleotide binding] 63737000833 dimerization interface [polypeptide binding]; other site 63737000834 Family description; Region: VCBS; pfam13517 63737000835 Family description; Region: VCBS; pfam13517 63737000836 Family description; Region: VCBS; pfam13517 63737000837 Family description; Region: VCBS; pfam13517 63737000838 Family description; Region: VCBS; pfam13517 63737000839 Family description; Region: VCBS; pfam13517 63737000840 Calx-beta domain; Region: Calx-beta; cl02522 63737000841 Calx-beta domain; Region: Calx-beta; pfam03160 63737000842 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 63737000843 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737000844 ATP binding site [chemical binding]; other site 63737000845 putative Mg++ binding site [ion binding]; other site 63737000846 helicase superfamily c-terminal domain; Region: HELICc; smart00490 63737000847 ATP-binding site [chemical binding]; other site 63737000848 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737000849 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 63737000850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737000851 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737000852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737000853 DNA binding residues [nucleotide binding] 63737000854 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 63737000855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737000856 Coenzyme A binding pocket [chemical binding]; other site 63737000857 carboxyl-terminal processing protease; Provisional; Region: PLN00049 63737000858 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 63737000859 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 63737000860 protein binding site [polypeptide binding]; other site 63737000861 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 63737000862 Catalytic dyad [active] 63737000863 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 63737000864 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 63737000865 Qi binding site; other site 63737000866 intrachain domain interface; other site 63737000867 interchain domain interface [polypeptide binding]; other site 63737000868 heme bH binding site [chemical binding]; other site 63737000869 heme bL binding site [chemical binding]; other site 63737000870 Qo binding site; other site 63737000871 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 63737000872 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 63737000873 interchain domain interface [polypeptide binding]; other site 63737000874 intrachain domain interface; other site 63737000875 Qi binding site; other site 63737000876 Qo binding site; other site 63737000877 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 63737000878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 63737000879 Mg2+ binding site [ion binding]; other site 63737000880 G-X-G motif; other site 63737000881 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 63737000882 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 63737000883 NADP-binding site; other site 63737000884 homotetramer interface [polypeptide binding]; other site 63737000885 substrate binding site [chemical binding]; other site 63737000886 homodimer interface [polypeptide binding]; other site 63737000887 active site 63737000888 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737000889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737000890 alkylphosphonate utilization operon protein PhnA; Region: phnA; TIGR00686 63737000891 RDD family; Region: RDD; pfam06271 63737000892 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737000893 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000894 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737000897 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 63737000898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737000899 Coenzyme A binding pocket [chemical binding]; other site 63737000900 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 63737000901 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 63737000902 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 63737000903 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 63737000904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737000905 gamma-glutamyl kinase; Provisional; Region: PRK05429 63737000906 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 63737000907 nucleotide binding site [chemical binding]; other site 63737000908 homotetrameric interface [polypeptide binding]; other site 63737000909 putative phosphate binding site [ion binding]; other site 63737000910 putative allosteric binding site; other site 63737000911 PUA domain; Region: PUA; pfam01472 63737000912 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 63737000913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 63737000914 nucleotide binding site [chemical binding]; other site 63737000915 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 63737000916 Uncharacterized conserved protein [Function unknown]; Region: COG1656 63737000917 Protein of unknown function DUF82; Region: DUF82; pfam01927 63737000918 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 63737000919 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 63737000920 putative dimer interface [polypeptide binding]; other site 63737000921 putative [2Fe-2S] cluster binding site [ion binding]; other site 63737000922 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 63737000923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737000924 non-specific DNA binding site [nucleotide binding]; other site 63737000925 salt bridge; other site 63737000926 sequence-specific DNA binding site [nucleotide binding]; other site 63737000927 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 63737000928 4Fe-4S binding domain; Region: Fer4; cl02805 63737000929 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 63737000930 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 63737000931 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 63737000932 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 63737000933 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 63737000934 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 63737000935 Subunit I/III interface [polypeptide binding]; other site 63737000936 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 63737000937 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 63737000938 ArsC family; Region: ArsC; pfam03960 63737000939 putative catalytic residues [active] 63737000940 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737000941 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737000942 active site 63737000943 ATP binding site [chemical binding]; other site 63737000944 substrate binding site [chemical binding]; other site 63737000945 activation loop (A-loop); other site 63737000946 Predicted ATPase [General function prediction only]; Region: COG3899 63737000947 AAA ATPase domain; Region: AAA_16; pfam13191 63737000948 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737000949 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737000950 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737000951 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737000952 dimer interface [polypeptide binding]; other site 63737000953 phosphorylation site [posttranslational modification] 63737000954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737000955 ATP binding site [chemical binding]; other site 63737000956 Mg2+ binding site [ion binding]; other site 63737000957 G-X-G motif; other site 63737000958 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 63737000959 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 63737000960 dimer interface [polypeptide binding]; other site 63737000961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737000962 catalytic residue [active] 63737000963 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 63737000964 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 63737000965 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 63737000966 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 63737000967 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 63737000968 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 63737000969 active site 63737000970 catalytic site [active] 63737000971 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 63737000972 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 63737000973 cyclase homology domain; Region: CHD; cd07302 63737000974 nucleotidyl binding site; other site 63737000975 metal binding site [ion binding]; metal-binding site 63737000976 dimer interface [polypeptide binding]; other site 63737000977 NACHT domain; Region: NACHT; pfam05729 63737000978 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 63737000979 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737000980 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000981 structural tetrad; other site 63737000982 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737000983 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000984 structural tetrad; other site 63737000985 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737000986 structural tetrad; other site 63737000987 FOG: CBS domain [General function prediction only]; Region: COG0517 63737000988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 63737000989 FOG: CBS domain [General function prediction only]; Region: COG0517 63737000990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611 63737000991 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737000992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737000993 putative active site [active] 63737000994 heme pocket [chemical binding]; other site 63737000995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737000996 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737000997 putative active site [active] 63737000998 heme pocket [chemical binding]; other site 63737000999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737001000 putative active site [active] 63737001001 heme pocket [chemical binding]; other site 63737001002 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737001003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737001004 putative active site [active] 63737001005 heme pocket [chemical binding]; other site 63737001006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737001007 dimer interface [polypeptide binding]; other site 63737001008 phosphorylation site [posttranslational modification] 63737001009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737001010 ATP binding site [chemical binding]; other site 63737001011 Mg2+ binding site [ion binding]; other site 63737001012 G-X-G motif; other site 63737001013 Response regulator receiver domain; Region: Response_reg; pfam00072 63737001014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737001015 active site 63737001016 phosphorylation site [posttranslational modification] 63737001017 intermolecular recognition site; other site 63737001018 dimerization interface [polypeptide binding]; other site 63737001019 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737001020 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737001021 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737001022 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737001023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737001024 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 63737001025 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 63737001026 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 63737001027 dimerization interface [polypeptide binding]; other site 63737001028 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 63737001029 ATP binding site [chemical binding]; other site 63737001030 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 63737001031 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 63737001032 HupF/HypC family; Region: HupF_HypC; pfam01455 63737001033 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 63737001034 Acylphosphatase; Region: Acylphosphatase; pfam00708 63737001035 HypF finger; Region: zf-HYPF; pfam07503 63737001036 HypF finger; Region: zf-HYPF; pfam07503 63737001037 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 63737001038 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 63737001039 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 63737001040 iron-sulfur cluster [ion binding]; other site 63737001041 [2Fe-2S] cluster binding site [ion binding]; other site 63737001042 hypothetical protein; Validated; Region: PRK00068 63737001043 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 63737001044 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 63737001045 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 63737001046 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 63737001047 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 63737001048 P-loop containing region of AAA domain; Region: AAA_29; cl17516 63737001049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737001050 Walker B; other site 63737001051 D-loop; other site 63737001052 H-loop/switch region; other site 63737001053 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 63737001054 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 63737001055 putative active site [active] 63737001056 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 63737001057 nickel binding site [ion binding]; other site 63737001058 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 63737001059 NADPH bind site [chemical binding]; other site 63737001060 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 63737001061 putative FMN binding site [chemical binding]; other site 63737001062 NADPH bind site [chemical binding]; other site 63737001063 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 63737001064 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 63737001065 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 63737001066 FeoA domain; Region: FeoA; pfam04023 63737001067 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737001068 catalytic loop [active] 63737001069 iron binding site [ion binding]; other site 63737001070 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 63737001071 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 63737001072 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 63737001073 ATP binding site [chemical binding]; other site 63737001074 substrate interface [chemical binding]; other site 63737001075 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 63737001076 Rop-like; Region: Rop-like; pfam05082 63737001077 Protein of unknown function, DUF269; Region: DUF269; pfam03270 63737001078 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 63737001079 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 63737001080 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 63737001081 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 63737001082 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 63737001083 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737001084 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 63737001085 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 63737001086 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 63737001087 MoFe protein beta/alpha subunit interactions; other site 63737001088 Beta subunit P cluster binding residues; other site 63737001089 MoFe protein beta subunit/Fe protein contacts; other site 63737001090 MoFe protein dimer/ dimer interactions; other site 63737001091 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737001092 active site 63737001093 catalytic residues [active] 63737001094 DNA binding site [nucleotide binding] 63737001095 Int/Topo IB signature motif; other site 63737001096 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 63737001097 putative active site [active] 63737001098 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 63737001099 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 63737001100 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 63737001101 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737001103 S-adenosylmethionine binding site [chemical binding]; other site 63737001104 Cache domain; Region: Cache_1; pfam02743 63737001105 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 63737001106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737001107 dimerization interface [polypeptide binding]; other site 63737001108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737001109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737001110 dimer interface [polypeptide binding]; other site 63737001111 phosphorylation site [posttranslational modification] 63737001112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737001113 ATP binding site [chemical binding]; other site 63737001114 Mg2+ binding site [ion binding]; other site 63737001115 G-X-G motif; other site 63737001116 Bacterial SH3 domain; Region: SH3_3; cl17532 63737001117 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 63737001118 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 63737001119 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 63737001120 TraX protein; Region: TraX; pfam05857 63737001121 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 63737001122 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 63737001123 putative active site [active] 63737001124 putative NTP binding site [chemical binding]; other site 63737001125 putative nucleic acid binding site [nucleotide binding]; other site 63737001126 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 63737001127 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 63737001128 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 63737001129 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 63737001130 nitrogenase reductase; Reviewed; Region: PRK13236 63737001131 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 63737001132 Nucleotide-binding sites [chemical binding]; other site 63737001133 Walker A motif; other site 63737001134 Switch I region of nucleotide binding site; other site 63737001135 Fe4S4 binding sites [ion binding]; other site 63737001136 Switch II region of nucleotide binding site; other site 63737001137 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 63737001138 apolar tunnel; other site 63737001139 heme binding site [chemical binding]; other site 63737001140 dimerization interface [polypeptide binding]; other site 63737001141 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 63737001142 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 63737001143 trimerization site [polypeptide binding]; other site 63737001144 active site 63737001145 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 63737001146 NifU-like domain; Region: NifU; pfam01106 63737001147 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 63737001148 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 63737001149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737001150 catalytic residue [active] 63737001151 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 63737001152 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 63737001153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737001154 FeS/SAM binding site; other site 63737001155 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 63737001156 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 63737001157 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 63737001158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737001159 Walker A motif; other site 63737001160 ATP binding site [chemical binding]; other site 63737001161 Walker B motif; other site 63737001162 HEAT repeats; Region: HEAT_2; pfam13646 63737001163 A new structural DNA glycosylase; Region: AlkD_like; cl11434 63737001164 HEAT repeats; Region: HEAT_2; pfam13646 63737001165 active site 63737001166 HEAT repeats; Region: HEAT_2; pfam13646 63737001167 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 63737001168 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 63737001169 active site 63737001170 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 63737001171 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 63737001172 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 63737001173 trimer interface [polypeptide binding]; other site 63737001174 active site 63737001175 substrate binding site [chemical binding]; other site 63737001176 CoA binding site [chemical binding]; other site 63737001177 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 63737001178 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 63737001179 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 63737001180 active site 63737001181 catalytic residues [active] 63737001182 metal binding site [ion binding]; metal-binding site 63737001183 NifZ domain; Region: NifZ; pfam04319 63737001184 NifT/FixU protein; Region: NifT; pfam06988 63737001185 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 63737001186 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 63737001187 dimer interface [polypeptide binding]; other site 63737001188 [2Fe-2S] cluster binding site [ion binding]; other site 63737001189 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 63737001190 putative acyl-acceptor binding pocket; other site 63737001191 prolyl-tRNA synthetase; Provisional; Region: PRK09194 63737001192 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 63737001193 dimer interface [polypeptide binding]; other site 63737001194 motif 1; other site 63737001195 active site 63737001196 motif 2; other site 63737001197 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 63737001198 putative deacylase active site [active] 63737001199 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 63737001200 active site 63737001201 motif 3; other site 63737001202 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 63737001203 anticodon binding site; other site 63737001204 Sporulation and spore germination; Region: Germane; pfam10646 63737001205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737001206 putative DNA binding site [nucleotide binding]; other site 63737001207 putative Zn2+ binding site [ion binding]; other site 63737001208 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 63737001209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 63737001210 carboxyltransferase (CT) interaction site; other site 63737001211 biotinylation site [posttranslational modification]; other site 63737001212 elongation factor P; Validated; Region: PRK00529 63737001213 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 63737001214 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 63737001215 RNA binding site [nucleotide binding]; other site 63737001216 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 63737001217 RNA binding site [nucleotide binding]; other site 63737001218 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 63737001219 active site 63737001220 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737001221 putative active site [active] 63737001222 thiamine monophosphate kinase; Provisional; Region: PRK05731 63737001223 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 63737001224 ATP binding site [chemical binding]; other site 63737001225 dimerization interface [polypeptide binding]; other site 63737001226 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 63737001227 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 63737001228 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 63737001229 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 63737001230 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 63737001231 active site 63737001232 (T/H)XGH motif; other site 63737001233 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 63737001234 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 63737001235 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 63737001236 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 63737001237 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 63737001238 FAD binding domain; Region: FAD_binding_4; pfam01565 63737001239 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 63737001240 hypothetical protein; Validated; Region: PRK00153 63737001241 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 63737001242 Low molecular weight phosphatase family; Region: LMWPc; cd00115 63737001243 active site 63737001244 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737001245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737001246 active site 63737001247 phosphorylation site [posttranslational modification] 63737001248 intermolecular recognition site; other site 63737001249 dimerization interface [polypeptide binding]; other site 63737001250 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737001251 DNA binding residues [nucleotide binding] 63737001252 dimerization interface [polypeptide binding]; other site 63737001253 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 63737001254 SmpB-tmRNA interface; other site 63737001255 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 63737001256 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 63737001257 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737001258 GAF domain; Region: GAF; pfam01590 63737001259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737001260 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737001261 dimer interface [polypeptide binding]; other site 63737001262 phosphorylation site [posttranslational modification] 63737001263 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 63737001264 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 63737001265 inhibitor-cofactor binding pocket; inhibition site 63737001266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001267 catalytic residue [active] 63737001268 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 63737001269 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 63737001270 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 63737001271 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 63737001272 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 63737001273 SLBB domain; Region: SLBB; pfam10531 63737001274 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737001275 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 63737001276 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737001277 Nucleotide binding site [chemical binding]; other site 63737001278 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 63737001279 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 63737001280 tropinone reductase; Provisional; Region: PRK09242 63737001281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737001282 NAD(P) binding site [chemical binding]; other site 63737001283 active site 63737001284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 63737001285 TPR motif; other site 63737001286 binding surface 63737001287 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737001288 putative active site [active] 63737001289 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 63737001290 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737001291 putative active site [active] 63737001292 excinuclease ABC subunit B; Provisional; Region: PRK05298 63737001293 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737001294 ATP binding site [chemical binding]; other site 63737001295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737001296 nucleotide binding region [chemical binding]; other site 63737001297 ATP-binding site [chemical binding]; other site 63737001298 Ultra-violet resistance protein B; Region: UvrB; pfam12344 63737001299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 63737001300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 63737001301 catalytic core [active] 63737001302 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 63737001303 Transposase; Region: DDE_Tnp_ISL3; pfam01610 63737001304 PIN domain; Region: PIN_3; pfam13470 63737001305 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737001306 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737001307 CHAT domain; Region: CHAT; pfam12770 63737001308 AAA ATPase domain; Region: AAA_16; pfam13191 63737001309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001310 binding surface 63737001311 TPR motif; other site 63737001312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001315 binding surface 63737001316 TPR motif; other site 63737001317 TPR repeat; Region: TPR_11; pfam13414 63737001318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001319 binding surface 63737001320 TPR motif; other site 63737001321 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001322 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 63737001323 active site 63737001324 Zn binding site [ion binding]; other site 63737001325 6-phosphofructokinase; Provisional; Region: PRK14071 63737001326 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 63737001327 active site 63737001328 ADP/pyrophosphate binding site [chemical binding]; other site 63737001329 dimerization interface [polypeptide binding]; other site 63737001330 allosteric effector site; other site 63737001331 fructose-1,6-bisphosphate binding site; other site 63737001332 GTPase Era; Reviewed; Region: era; PRK00089 63737001333 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 63737001334 G1 box; other site 63737001335 GTP/Mg2+ binding site [chemical binding]; other site 63737001336 Switch I region; other site 63737001337 G2 box; other site 63737001338 Switch II region; other site 63737001339 G3 box; other site 63737001340 G4 box; other site 63737001341 G5 box; other site 63737001342 KH domain; Region: KH_2; pfam07650 63737001343 Response regulator receiver domain; Region: Response_reg; pfam00072 63737001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737001345 active site 63737001346 phosphorylation site [posttranslational modification] 63737001347 intermolecular recognition site; other site 63737001348 dimerization interface [polypeptide binding]; other site 63737001349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737001350 DNA binding residues [nucleotide binding] 63737001351 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 63737001352 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 63737001353 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 63737001354 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 63737001355 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 63737001356 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 63737001357 homodimer interface [polypeptide binding]; other site 63737001358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001359 catalytic residue [active] 63737001360 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 63737001361 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 63737001362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737001363 Walker A/P-loop; other site 63737001364 ATP binding site [chemical binding]; other site 63737001365 Q-loop/lid; other site 63737001366 ABC transporter signature motif; other site 63737001367 Walker B; other site 63737001368 D-loop; other site 63737001369 H-loop/switch region; other site 63737001370 ABC-2 type transporter; Region: ABC2_membrane; cl17235 63737001371 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 63737001372 ABC-2 type transporter; Region: ABC2_membrane; cl17235 63737001373 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 63737001374 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737001375 catalytic triad [active] 63737001376 cobyric acid synthase; Provisional; Region: PRK00784 63737001377 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 63737001378 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 63737001379 catalytic triad [active] 63737001380 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737001381 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737001382 catalytic loop [active] 63737001383 iron binding site [ion binding]; other site 63737001384 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 63737001385 putative hydrophobic ligand binding site [chemical binding]; other site 63737001386 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 63737001387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737001388 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 63737001389 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 63737001390 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 63737001391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001392 binding surface 63737001393 TPR motif; other site 63737001394 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 63737001395 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 63737001396 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 63737001397 putative NAD(P) binding site [chemical binding]; other site 63737001398 putative active site [active] 63737001399 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737001400 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 63737001401 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 63737001402 metal-binding site [ion binding] 63737001403 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737001404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737001405 motif I; other site 63737001406 motif II; other site 63737001407 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 63737001408 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 63737001409 CAAX protease self-immunity; Region: Abi; pfam02517 63737001410 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737001411 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737001412 phosphopeptide binding site; other site 63737001413 Ycf46; Provisional; Region: ycf46; CHL00195 63737001414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737001415 Walker A motif; other site 63737001416 ATP binding site [chemical binding]; other site 63737001417 Walker B motif; other site 63737001418 arginine finger; other site 63737001419 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 63737001420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 63737001421 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 63737001422 NADP binding site [chemical binding]; other site 63737001423 substrate binding site [chemical binding]; other site 63737001424 active site 63737001425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 63737001426 XisH protein; Region: XisH; pfam08814 63737001427 XisI protein; Region: XisI; pfam08869 63737001428 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 63737001429 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737001430 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 63737001431 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 63737001432 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 63737001433 active site residue [active] 63737001434 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 63737001435 active site residue [active] 63737001436 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737001437 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737001438 structural tetrad; other site 63737001439 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 63737001440 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 63737001441 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 63737001442 active site 63737001443 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737001444 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737001445 structural tetrad; other site 63737001446 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 63737001447 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737001448 Soluble P-type ATPase [General function prediction only]; Region: COG4087 63737001449 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 63737001450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 63737001451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737001452 Walker A/P-loop; other site 63737001453 ATP binding site [chemical binding]; other site 63737001454 Q-loop/lid; other site 63737001455 ABC transporter signature motif; other site 63737001456 Walker B; other site 63737001457 D-loop; other site 63737001458 H-loop/switch region; other site 63737001459 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 63737001460 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225 63737001461 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 63737001462 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 63737001463 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 63737001464 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 63737001465 putative active site [active] 63737001466 putative substrate binding site [chemical binding]; other site 63737001467 putative cosubstrate binding site; other site 63737001468 catalytic site [active] 63737001469 putative acetyltransferase; Provisional; Region: PRK03624 63737001470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737001471 Coenzyme A binding pocket [chemical binding]; other site 63737001472 M domain of GW182; Region: M_domain; pfam12938 63737001473 tellurium resistance terB-like protein; Region: terB_like; cd07177 63737001474 metal binding site [ion binding]; metal-binding site 63737001475 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737001476 Dynamin family; Region: Dynamin_N; pfam00350 63737001477 G1 box; other site 63737001478 GTP/Mg2+ binding site [chemical binding]; other site 63737001479 G2 box; other site 63737001480 Switch I region; other site 63737001481 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 63737001482 G3 box; other site 63737001483 Switch II region; other site 63737001484 GTP/Mg2+ binding site [chemical binding]; other site 63737001485 G4 box; other site 63737001486 G5 box; other site 63737001487 Lipoxygenase; Region: Lipoxygenase; pfam00305 63737001488 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737001489 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737001490 metal binding site [ion binding]; metal-binding site 63737001491 active site 63737001492 I-site; other site 63737001493 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 63737001494 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 63737001495 motif 1; other site 63737001496 active site 63737001497 motif 2; other site 63737001498 motif 3; other site 63737001499 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 63737001500 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 63737001501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737001502 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 63737001503 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737001504 dimerization interface [polypeptide binding]; other site 63737001505 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737001506 dimer interface [polypeptide binding]; other site 63737001507 phosphorylation site [posttranslational modification] 63737001508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737001509 ATP binding site [chemical binding]; other site 63737001510 Mg2+ binding site [ion binding]; other site 63737001511 G-X-G motif; other site 63737001512 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 63737001513 NADH(P)-binding; Region: NAD_binding_10; pfam13460 63737001514 NAD(P) binding site [chemical binding]; other site 63737001515 putative active site [active] 63737001516 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 63737001517 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 63737001518 nucleotide binding site [chemical binding]; other site 63737001519 NEF interaction site [polypeptide binding]; other site 63737001520 SBD interface [polypeptide binding]; other site 63737001521 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737001522 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737001523 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 63737001524 Walker A/P-loop; other site 63737001525 ATP binding site [chemical binding]; other site 63737001526 Q-loop/lid; other site 63737001527 ABC transporter signature motif; other site 63737001528 Walker B; other site 63737001529 D-loop; other site 63737001530 H-loop/switch region; other site 63737001531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737001532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737001533 active site 63737001534 catalytic tetrad [active] 63737001535 short chain dehydrogenase; Provisional; Region: PRK06180 63737001536 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 63737001537 NADP binding site [chemical binding]; other site 63737001538 active site 63737001539 steroid binding site; other site 63737001540 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 63737001541 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 63737001542 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 63737001543 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 63737001544 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 63737001545 putative NAD(P) binding site [chemical binding]; other site 63737001546 putative substrate binding site [chemical binding]; other site 63737001547 catalytic Zn binding site [ion binding]; other site 63737001548 structural Zn binding site [ion binding]; other site 63737001549 dimer interface [polypeptide binding]; other site 63737001550 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 63737001551 classical (c) SDRs; Region: SDR_c; cd05233 63737001552 NAD(P) binding site [chemical binding]; other site 63737001553 active site 63737001554 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 63737001555 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 63737001556 short chain dehydrogenase; Provisional; Region: PRK06172 63737001557 classical (c) SDRs; Region: SDR_c; cd05233 63737001558 NAD(P) binding site [chemical binding]; other site 63737001559 active site 63737001560 Uncharacterized conserved protein [Function unknown]; Region: COG1359 63737001561 Uncharacterized conserved protein [Function unknown]; Region: COG4925 63737001562 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 63737001563 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 63737001564 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 63737001565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737001566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001567 TPR motif; other site 63737001568 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001569 binding surface 63737001570 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001572 binding surface 63737001573 TPR motif; other site 63737001574 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001576 binding surface 63737001577 TPR motif; other site 63737001578 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001580 aspartate aminotransferase; Provisional; Region: PRK05957 63737001581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001583 homodimer interface [polypeptide binding]; other site 63737001584 catalytic residue [active] 63737001585 Uncharacterized conserved protein [Function unknown]; Region: COG0432 63737001586 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737001587 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 63737001588 [2Fe-2S] cluster binding site [ion binding]; other site 63737001589 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 63737001590 hydrophobic ligand binding site; other site 63737001591 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737001592 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737001593 ligand binding site [chemical binding]; other site 63737001594 flexible hinge region; other site 63737001595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737001596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737001597 ATP binding site [chemical binding]; other site 63737001598 Mg2+ binding site [ion binding]; other site 63737001599 G-X-G motif; other site 63737001600 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737001601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737001602 active site 63737001603 phosphorylation site [posttranslational modification] 63737001604 intermolecular recognition site; other site 63737001605 dimerization interface [polypeptide binding]; other site 63737001606 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 63737001607 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 63737001608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737001609 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 63737001610 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737001611 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 63737001612 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 63737001613 Predicted membrane protein [Function unknown]; Region: COG3431 63737001614 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737001615 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 63737001616 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 63737001617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737001618 catalytic residue [active] 63737001619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737001620 S-adenosylmethionine binding site [chemical binding]; other site 63737001621 TPR repeat; Region: TPR_11; pfam13414 63737001622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001623 TPR motif; other site 63737001624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737001625 binding surface 63737001626 TPR repeat; Region: TPR_11; pfam13414 63737001627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001628 binding surface 63737001629 TPR motif; other site 63737001630 TPR repeat; Region: TPR_11; pfam13414 63737001631 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 63737001632 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 63737001633 S-layer homology domain; Region: SLH; pfam00395 63737001634 S-layer homology domain; Region: SLH; pfam00395 63737001635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 63737001636 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737001637 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 63737001638 inhibitor binding site; inhibition site 63737001639 catalytic motif [active] 63737001640 Catalytic residue [active] 63737001641 Active site flap [active] 63737001642 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 63737001643 CHASE3 domain; Region: CHASE3; pfam05227 63737001644 PAS fold; Region: PAS_4; pfam08448 63737001645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737001646 putative active site [active] 63737001647 heme pocket [chemical binding]; other site 63737001648 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737001649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737001650 putative active site [active] 63737001651 heme pocket [chemical binding]; other site 63737001652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737001653 dimer interface [polypeptide binding]; other site 63737001654 phosphorylation site [posttranslational modification] 63737001655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737001656 ATP binding site [chemical binding]; other site 63737001657 Mg2+ binding site [ion binding]; other site 63737001658 G-X-G motif; other site 63737001659 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 63737001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737001661 NAD(P) binding site [chemical binding]; other site 63737001662 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 63737001663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737001664 active site 63737001665 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 63737001666 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 63737001667 GDP-binding site [chemical binding]; other site 63737001668 ACT binding site; other site 63737001669 IMP binding site; other site 63737001670 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 63737001671 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 63737001672 5S rRNA interface [nucleotide binding]; other site 63737001673 CTC domain interface [polypeptide binding]; other site 63737001674 L16 interface [polypeptide binding]; other site 63737001675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 63737001676 Predicted kinase [General function prediction only]; Region: COG0645 63737001677 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 63737001678 ATP-binding site [chemical binding]; other site 63737001679 Gluconate-6-phosphate binding site [chemical binding]; other site 63737001680 Uncharacterized conserved protein [Function unknown]; Region: COG1434 63737001681 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 63737001682 putative active site [active] 63737001683 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 63737001684 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 63737001685 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 63737001686 putative NAD(P) binding site [chemical binding]; other site 63737001687 putative active site [active] 63737001688 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 63737001689 dimer interface [polypeptide binding]; other site 63737001690 FMN binding site [chemical binding]; other site 63737001691 NADPH bind site [chemical binding]; other site 63737001692 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 63737001693 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737001694 substrate binding pocket [chemical binding]; other site 63737001695 membrane-bound complex binding site; other site 63737001696 hinge residues; other site 63737001697 hypothetical protein; Provisional; Region: PRK06208 63737001698 intersubunit interface [polypeptide binding]; other site 63737001699 active site 63737001700 Zn2+ binding site [ion binding]; other site 63737001701 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 63737001702 RRXRR protein; Region: RRXRR; pfam14239 63737001703 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 63737001704 active site 63737001705 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 63737001706 dimer interface [polypeptide binding]; other site 63737001707 non-prolyl cis peptide bond; other site 63737001708 insertion regions; other site 63737001709 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737001710 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737001711 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737001712 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 63737001713 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 63737001714 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 63737001715 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 63737001716 active site 63737001717 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 63737001718 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 63737001719 active site 63737001720 nucleotide binding site [chemical binding]; other site 63737001721 HIGH motif; other site 63737001722 KMSKS motif; other site 63737001723 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 63737001724 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 63737001725 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 63737001726 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 63737001727 Beta-lactamase; Region: Beta-lactamase; pfam00144 63737001728 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737001729 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 63737001730 putative ADP-binding pocket [chemical binding]; other site 63737001731 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737001732 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 63737001733 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 63737001734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737001735 active site 63737001736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737001737 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737001738 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 63737001739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737001740 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 63737001741 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 63737001742 active site 63737001743 substrate binding site [chemical binding]; other site 63737001744 metal binding site [ion binding]; metal-binding site 63737001745 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 63737001746 heme binding pocket [chemical binding]; other site 63737001747 heme ligand [chemical binding]; other site 63737001748 Transcriptional regulator [Transcription]; Region: LysR; COG0583 63737001749 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737001750 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 63737001751 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 63737001752 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 63737001753 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 63737001754 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 63737001755 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 63737001756 active site 63737001757 dimer interface [polypeptide binding]; other site 63737001758 non-prolyl cis peptide bond; other site 63737001759 insertion regions; other site 63737001760 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 63737001761 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 63737001762 Flavin binding site [chemical binding]; other site 63737001763 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 63737001764 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 63737001765 Flavin binding site [chemical binding]; other site 63737001766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001767 binding surface 63737001768 TPR motif; other site 63737001769 TPR repeat; Region: TPR_11; pfam13414 63737001770 TPR repeat; Region: TPR_11; pfam13414 63737001771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001772 binding surface 63737001773 TPR motif; other site 63737001774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001775 binding surface 63737001776 TPR repeat; Region: TPR_11; pfam13414 63737001777 TPR motif; other site 63737001778 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737001779 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001780 binding surface 63737001781 TPR motif; other site 63737001782 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 63737001783 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 63737001784 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 63737001785 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 63737001786 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 63737001787 2TM domain; Region: 2TM; pfam13239 63737001788 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 63737001789 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 63737001790 trimer interface [polypeptide binding]; other site 63737001791 dimer interface [polypeptide binding]; other site 63737001792 putative active site [active] 63737001793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737001794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737001795 putative substrate translocation pore; other site 63737001796 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 63737001797 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 63737001798 Ligand binding site; other site 63737001799 Putative Catalytic site; other site 63737001800 DXD motif; other site 63737001801 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 63737001802 NlpC/P60 family; Region: NLPC_P60; pfam00877 63737001803 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 63737001804 DoxX-like family; Region: DoxX_3; pfam13781 63737001805 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 63737001806 TIR domain; Region: TIR_2; pfam13676 63737001807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001808 binding surface 63737001809 TPR motif; other site 63737001810 TPR repeat; Region: TPR_11; pfam13414 63737001811 TPR repeat; Region: TPR_11; pfam13414 63737001812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001813 binding surface 63737001814 TPR motif; other site 63737001815 TPR repeat; Region: TPR_11; pfam13414 63737001816 TPR repeat; Region: TPR_11; pfam13414 63737001817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001818 binding surface 63737001819 TPR motif; other site 63737001820 TPR repeat; Region: TPR_11; pfam13414 63737001821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001822 binding surface 63737001823 TPR motif; other site 63737001824 TIR domain; Region: TIR_2; pfam13676 63737001825 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 63737001826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 63737001827 nucleotide binding site [chemical binding]; other site 63737001828 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 63737001829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737001830 dimer interface [polypeptide binding]; other site 63737001831 conserved gate region; other site 63737001832 ABC-ATPase subunit interface; other site 63737001833 PIN domain; Region: PIN_3; cl17397 63737001834 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 63737001835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737001836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737001837 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 63737001838 catalytic residues [active] 63737001839 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737001840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737001841 S-adenosylmethionine binding site [chemical binding]; other site 63737001842 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737001843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737001844 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 63737001845 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001846 TPR repeat; Region: TPR_11; pfam13414 63737001847 binding surface 63737001848 TPR motif; other site 63737001849 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 63737001850 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 63737001851 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 63737001852 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 63737001853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737001854 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 63737001855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737001856 TPR motif; other site 63737001857 binding surface 63737001858 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737001859 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 63737001860 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 63737001861 inhibitor-cofactor binding pocket; inhibition site 63737001862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001863 catalytic residue [active] 63737001864 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737001865 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737001866 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 63737001867 ligand binding site; other site 63737001868 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 63737001869 pseudaminic acid synthase; Region: PseI; TIGR03586 63737001870 NeuB family; Region: NeuB; pfam03102 63737001871 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 63737001872 NeuB binding interface [polypeptide binding]; other site 63737001873 putative substrate binding site [chemical binding]; other site 63737001874 WbqC-like protein family; Region: WbqC; pfam08889 63737001875 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737001876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737001877 S-adenosylmethionine binding site [chemical binding]; other site 63737001878 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 63737001879 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737001880 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 63737001881 ligand binding site; other site 63737001882 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 63737001883 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 63737001884 inhibitor-cofactor binding pocket; inhibition site 63737001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001886 catalytic residue [active] 63737001887 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 63737001888 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 63737001889 NAD(P) binding site [chemical binding]; other site 63737001890 homodimer interface [polypeptide binding]; other site 63737001891 substrate binding site [chemical binding]; other site 63737001892 active site 63737001893 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 63737001894 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737001895 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737001896 phosphopeptide binding site; other site 63737001897 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737001898 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737001899 active site 63737001900 ATP binding site [chemical binding]; other site 63737001901 substrate binding site [chemical binding]; other site 63737001902 activation loop (A-loop); other site 63737001903 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 63737001904 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 63737001905 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 63737001906 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 63737001907 active site 63737001908 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 63737001909 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737001910 substrate binding pocket [chemical binding]; other site 63737001911 membrane-bound complex binding site; other site 63737001912 hinge residues; other site 63737001913 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 63737001914 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737001915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001916 homodimer interface [polypeptide binding]; other site 63737001917 catalytic residue [active] 63737001918 hypothetical protein; Provisional; Region: PRK04194 63737001919 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 63737001920 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 63737001921 Protein of unknown function (DUF751); Region: DUF751; pfam05421 63737001922 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 63737001923 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 63737001924 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 63737001925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737001926 NAD(P) binding site [chemical binding]; other site 63737001927 active site 63737001928 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 63737001929 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 63737001930 Response regulator receiver domain; Region: Response_reg; pfam00072 63737001931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737001932 active site 63737001933 phosphorylation site [posttranslational modification] 63737001934 intermolecular recognition site; other site 63737001935 dimerization interface [polypeptide binding]; other site 63737001936 GMP synthase; Reviewed; Region: guaA; PRK00074 63737001937 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 63737001938 AMP/PPi binding site [chemical binding]; other site 63737001939 candidate oxyanion hole; other site 63737001940 catalytic triad [active] 63737001941 potential glutamine specificity residues [chemical binding]; other site 63737001942 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 63737001943 ATP Binding subdomain [chemical binding]; other site 63737001944 Ligand Binding sites [chemical binding]; other site 63737001945 Dimerization subdomain; other site 63737001946 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 63737001947 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 63737001948 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 63737001949 CP12 domain; Region: CP12; pfam02672 63737001950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 63737001951 FIST N domain; Region: FIST; pfam08495 63737001952 FIST C domain; Region: FIST_C; pfam10442 63737001953 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 63737001954 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 63737001955 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737001956 Soluble P-type ATPase [General function prediction only]; Region: COG4087 63737001957 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 63737001958 S-layer homology domain; Region: SLH; pfam00395 63737001959 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737001960 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 63737001961 16S/18S rRNA binding site [nucleotide binding]; other site 63737001962 S13e-L30e interaction site [polypeptide binding]; other site 63737001963 25S rRNA binding site [nucleotide binding]; other site 63737001964 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 63737001965 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 63737001966 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 63737001967 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 63737001968 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737001969 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737001970 protein binding site [polypeptide binding]; other site 63737001971 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 63737001972 ATP adenylyltransferase; Region: ATP_transf; pfam09830 63737001973 phycoerythrobilin:ferredoxin oxidoreductase; Provisional; Region: PRK13250 63737001974 dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247 63737001975 CpeS-like protein; Region: CpeS; pfam09367 63737001976 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737001977 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737001978 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737001979 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737001980 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737001981 HEAT repeats; Region: HEAT_2; pfam13646 63737001982 HEAT repeats; Region: HEAT_2; pfam13646 63737001983 Phycobilisome protein; Region: Phycobilisome; cl08227 63737001984 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737001985 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 63737001986 CpeS-like protein; Region: CpeS; pfam09367 63737001987 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 63737001988 S-layer homology domain; Region: SLH; pfam00395 63737001989 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737001990 threonine synthase; Reviewed; Region: PRK06721 63737001991 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 63737001992 homodimer interface [polypeptide binding]; other site 63737001993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737001994 catalytic residue [active] 63737001995 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 63737001996 Virulence-associated protein E; Region: VirE; pfam05272 63737001997 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 63737001998 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737001999 active site 63737002000 catalytic residues [active] 63737002001 DNA binding site [nucleotide binding] 63737002002 Int/Topo IB signature motif; other site 63737002003 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 63737002004 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737002005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737002006 homodimer interface [polypeptide binding]; other site 63737002007 catalytic residue [active] 63737002008 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 63737002009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737002010 S-adenosylmethionine binding site [chemical binding]; other site 63737002011 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 63737002012 pseudouridine synthase; Region: TIGR00093 63737002013 probable active site [active] 63737002014 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 63737002015 zinc binding site [ion binding]; other site 63737002016 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737002017 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 63737002018 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 63737002019 FAD binding domain; Region: FAD_binding_4; pfam01565 63737002020 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 63737002021 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 63737002022 Cysteine-rich domain; Region: CCG; pfam02754 63737002023 Cysteine-rich domain; Region: CCG; pfam02754 63737002024 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 63737002025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737002026 Protein of unknown function, DUF258; Region: DUF258; pfam03193 63737002027 CHASE2 domain; Region: CHASE2; cl01732 63737002028 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737002029 CHASE2 domain; Region: CHASE2; pfam05226 63737002030 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737002031 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737002032 motif II; other site 63737002033 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 63737002034 MoaE interaction surface [polypeptide binding]; other site 63737002035 thiocarboxylated glycine; other site 63737002036 threonine synthase; Validated; Region: PRK07591 63737002037 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 63737002038 homodimer interface [polypeptide binding]; other site 63737002039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737002040 catalytic residue [active] 63737002041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 63737002042 conserved repeat domain; Region: B_ant_repeat; TIGR01451 63737002043 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 63737002044 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 63737002045 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 63737002046 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 63737002047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737002048 FeS/SAM binding site; other site 63737002049 TRAM domain; Region: TRAM; pfam01938 63737002050 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 63737002051 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 63737002052 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737002053 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737002054 NACHT domain; Region: NACHT; pfam05729 63737002055 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 63737002056 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 63737002057 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 63737002058 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 63737002059 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 63737002060 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 63737002061 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 63737002062 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 63737002063 putative dimer interface [polypeptide binding]; other site 63737002064 threonine dehydratase; Reviewed; Region: PRK09224 63737002065 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 63737002066 tetramer interface [polypeptide binding]; other site 63737002067 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737002068 catalytic residue [active] 63737002069 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 63737002070 putative Ile/Val binding site [chemical binding]; other site 63737002071 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 63737002072 putative Ile/Val binding site [chemical binding]; other site 63737002073 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 63737002074 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 63737002075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737002076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737002077 active site 63737002078 catalytic tetrad [active] 63737002079 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737002080 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 63737002081 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737002082 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 63737002083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 63737002084 Uncharacterized conserved protein [Function unknown]; Region: COG4748 63737002085 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 63737002086 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 63737002087 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737002088 active site 63737002089 catalytic residues [active] 63737002090 DNA binding site [nucleotide binding] 63737002091 Int/Topo IB signature motif; other site 63737002092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737002093 active site 63737002094 DNA binding site [nucleotide binding] 63737002095 Int/Topo IB signature motif; other site 63737002096 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 63737002097 DNA-binding interface [nucleotide binding]; DNA binding site 63737002098 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 63737002099 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 63737002100 ferredoxin-sulfite reductase; Region: sir; TIGR02042 63737002101 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 63737002102 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 63737002103 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737002104 putative active site [active] 63737002105 RNA methyltransferase, RsmE family; Region: TIGR00046 63737002106 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 63737002107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 63737002108 binding surface 63737002109 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737002110 TPR motif; other site 63737002111 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 63737002112 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 63737002113 alpha-gamma subunit interface [polypeptide binding]; other site 63737002114 beta-gamma subunit interface [polypeptide binding]; other site 63737002115 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 63737002116 gamma-beta subunit interface [polypeptide binding]; other site 63737002117 alpha-beta subunit interface [polypeptide binding]; other site 63737002118 urease subunit alpha; Reviewed; Region: ureC; PRK13207 63737002119 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 63737002120 subunit interactions [polypeptide binding]; other site 63737002121 active site 63737002122 flap region; other site 63737002123 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 63737002124 YcfA-like protein; Region: YcfA; pfam07927 63737002125 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 63737002126 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 63737002127 ring oligomerisation interface [polypeptide binding]; other site 63737002128 ATP/Mg binding site [chemical binding]; other site 63737002129 stacking interactions; other site 63737002130 hinge regions; other site 63737002131 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 63737002132 oligomerisation interface [polypeptide binding]; other site 63737002133 mobile loop; other site 63737002134 roof hairpin; other site 63737002135 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 63737002136 dimer interface [polypeptide binding]; other site 63737002137 [2Fe-2S] cluster binding site [ion binding]; other site 63737002138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737002139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002140 active site 63737002141 phosphorylation site [posttranslational modification] 63737002142 intermolecular recognition site; other site 63737002143 dimerization interface [polypeptide binding]; other site 63737002144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737002145 DNA binding residues [nucleotide binding] 63737002146 dimerization interface [polypeptide binding]; other site 63737002147 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 63737002148 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875 63737002149 putative active site [active] 63737002150 TPR repeat; Region: TPR_11; pfam13414 63737002151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737002152 binding surface 63737002153 TPR motif; other site 63737002154 TPR repeat; Region: TPR_11; pfam13414 63737002155 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737002156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737002157 binding surface 63737002158 TPR motif; other site 63737002159 TIR domain; Region: TIR_2; pfam13676 63737002160 Response regulator receiver domain; Region: Response_reg; pfam00072 63737002161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002162 active site 63737002163 phosphorylation site [posttranslational modification] 63737002164 intermolecular recognition site; other site 63737002165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002166 dimerization interface [polypeptide binding]; other site 63737002167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737002168 dimer interface [polypeptide binding]; other site 63737002169 phosphorylation site [posttranslational modification] 63737002170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002171 ATP binding site [chemical binding]; other site 63737002172 Mg2+ binding site [ion binding]; other site 63737002173 G-X-G motif; other site 63737002174 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 63737002175 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 63737002176 NAD(P) binding site [chemical binding]; other site 63737002177 catalytic residues [active] 63737002178 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 63737002179 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 63737002180 Moco binding site; other site 63737002181 metal coordination site [ion binding]; other site 63737002182 ribosomal protein L32; Validated; Region: rpl32; CHL00152 63737002183 Caspase domain; Region: Peptidase_C14; pfam00656 63737002184 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737002185 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737002186 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 63737002187 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 63737002188 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 63737002189 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 63737002190 dihydrodipicolinate synthase; Region: dapA; TIGR00674 63737002191 dimer interface [polypeptide binding]; other site 63737002192 active site 63737002193 catalytic residue [active] 63737002194 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 63737002195 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 63737002196 trigger factor; Provisional; Region: tig; PRK01490 63737002197 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 63737002198 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 63737002199 Clp protease; Region: CLP_protease; pfam00574 63737002200 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 63737002201 oligomer interface [polypeptide binding]; other site 63737002202 active site residues [active] 63737002203 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 63737002204 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 63737002205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737002206 Walker A motif; other site 63737002207 ATP binding site [chemical binding]; other site 63737002208 Walker B motif; other site 63737002209 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 63737002210 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737002211 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737002212 Predicted transcriptional regulators [Transcription]; Region: COG1725 63737002213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 63737002214 DNA-binding site [nucleotide binding]; DNA binding site 63737002215 Dienelactone hydrolase family; Region: DLH; pfam01738 63737002216 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 63737002217 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 63737002218 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 63737002219 RNA binding site [nucleotide binding]; other site 63737002220 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 63737002221 RNA binding site [nucleotide binding]; other site 63737002222 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 63737002223 RNA binding site [nucleotide binding]; other site 63737002224 TIR domain; Region: TIR_2; pfam13676 63737002225 GUN4-like; Region: GUN4; pfam05419 63737002226 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 63737002227 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 63737002228 NAD(P) binding site [chemical binding]; other site 63737002229 putative active site [active] 63737002230 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 63737002231 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 63737002232 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737002233 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 63737002234 active site 63737002235 catalytic triad [active] 63737002236 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 63737002237 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 63737002238 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 63737002239 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737002240 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737002241 active site 63737002242 catalytic residues [active] 63737002243 DNA binding site [nucleotide binding] 63737002244 Int/Topo IB signature motif; other site 63737002245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737002246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737002247 salt bridge; other site 63737002248 non-specific DNA binding site [nucleotide binding]; other site 63737002249 sequence-specific DNA binding site [nucleotide binding]; other site 63737002250 Double zinc ribbon; Region: DZR; pfam12773 63737002251 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 63737002252 CARDB; Region: CARDB; pfam07705 63737002253 Uncharacterized conserved protein [Function unknown]; Region: COG1572 63737002254 CARDB; Region: CARDB; pfam07705 63737002255 CARDB; Region: CARDB; pfam07705 63737002256 CARDB; Region: CARDB; pfam07705 63737002257 CARDB; Region: CARDB; pfam07705 63737002258 CARDB; Region: CARDB; pfam07705 63737002259 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 63737002260 catalytic triad [active] 63737002261 putative active site [active] 63737002262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 63737002263 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 63737002264 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 63737002265 putative active site [active] 63737002266 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737002267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737002268 Walker A/P-loop; other site 63737002269 ATP binding site [chemical binding]; other site 63737002270 Q-loop/lid; other site 63737002271 ABC transporter signature motif; other site 63737002272 Walker B; other site 63737002273 D-loop; other site 63737002274 H-loop/switch region; other site 63737002275 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 63737002276 Integral membrane protein DUF92; Region: DUF92; pfam01940 63737002277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737002278 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 63737002279 active site 63737002280 metal binding site [ion binding]; metal-binding site 63737002281 Lipase (class 2); Region: Lipase_2; pfam01674 63737002282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737002283 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737002284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737002285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737002286 active site 63737002287 ATP binding site [chemical binding]; other site 63737002288 substrate binding site [chemical binding]; other site 63737002289 activation loop (A-loop); other site 63737002290 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 63737002291 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 63737002292 putative dimer interface [polypeptide binding]; other site 63737002293 putative anticodon binding site; other site 63737002294 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 63737002295 homodimer interface [polypeptide binding]; other site 63737002296 motif 1; other site 63737002297 motif 2; other site 63737002298 active site 63737002299 motif 3; other site 63737002300 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 63737002301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 63737002302 ATP binding site [chemical binding]; other site 63737002303 Mg2+ binding site [ion binding]; other site 63737002304 G-X-G motif; other site 63737002305 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 63737002306 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 63737002307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737002308 S-adenosylmethionine binding site [chemical binding]; other site 63737002309 Phycobilisome protein; Region: Phycobilisome; cl08227 63737002310 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 63737002311 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 63737002312 dimerization interface [polypeptide binding]; other site 63737002313 ATP binding site [chemical binding]; other site 63737002314 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 63737002315 dimerization interface [polypeptide binding]; other site 63737002316 ATP binding site [chemical binding]; other site 63737002317 amidophosphoribosyltransferase; Provisional; Region: PRK07349 63737002318 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 63737002319 active site 63737002320 tetramer interface [polypeptide binding]; other site 63737002321 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737002322 active site 63737002323 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 63737002324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737002325 dimer interface [polypeptide binding]; other site 63737002326 conserved gate region; other site 63737002327 putative PBP binding loops; other site 63737002328 ABC-ATPase subunit interface; other site 63737002329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737002330 active site 63737002331 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 63737002332 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 63737002333 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737002334 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737002335 phosphopeptide binding site; other site 63737002336 Transglycosylase; Region: Transgly; pfam00912 63737002337 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 63737002338 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737002339 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 63737002340 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 63737002341 lipoprotein signal peptidase; Provisional; Region: PRK14787 63737002342 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 63737002343 PBP superfamily domain; Region: PBP_like_2; cl17296 63737002344 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 63737002345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737002346 dimer interface [polypeptide binding]; other site 63737002347 conserved gate region; other site 63737002348 putative PBP binding loops; other site 63737002349 ABC-ATPase subunit interface; other site 63737002350 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 63737002351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737002352 dimer interface [polypeptide binding]; other site 63737002353 conserved gate region; other site 63737002354 putative PBP binding loops; other site 63737002355 ABC-ATPase subunit interface; other site 63737002356 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 63737002357 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 63737002358 Walker A/P-loop; other site 63737002359 ATP binding site [chemical binding]; other site 63737002360 Q-loop/lid; other site 63737002361 ABC transporter signature motif; other site 63737002362 Walker B; other site 63737002363 D-loop; other site 63737002364 H-loop/switch region; other site 63737002365 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737002366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002367 active site 63737002368 phosphorylation site [posttranslational modification] 63737002369 intermolecular recognition site; other site 63737002370 dimerization interface [polypeptide binding]; other site 63737002371 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002372 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737002373 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002374 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737002375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737002377 dimer interface [polypeptide binding]; other site 63737002378 phosphorylation site [posttranslational modification] 63737002379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002380 ATP binding site [chemical binding]; other site 63737002381 Mg2+ binding site [ion binding]; other site 63737002382 G-X-G motif; other site 63737002383 Response regulator receiver domain; Region: Response_reg; pfam00072 63737002384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002385 active site 63737002386 phosphorylation site [posttranslational modification] 63737002387 intermolecular recognition site; other site 63737002388 dimerization interface [polypeptide binding]; other site 63737002389 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 63737002390 cyclase homology domain; Region: CHD; cd07302 63737002391 nucleotidyl binding site; other site 63737002392 metal binding site [ion binding]; metal-binding site 63737002393 dimer interface [polypeptide binding]; other site 63737002394 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 63737002395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737002396 Coenzyme A binding pocket [chemical binding]; other site 63737002397 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 63737002398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737002399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737002400 homodimer interface [polypeptide binding]; other site 63737002401 catalytic residue [active] 63737002402 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 63737002403 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 63737002404 glutathione reductase; Validated; Region: PRK06116 63737002405 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737002406 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737002407 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737002408 FecR protein; Region: FecR; pfam04773 63737002409 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 63737002410 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 63737002411 active site residue [active] 63737002412 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 63737002413 active site residue [active] 63737002414 Uncharacterized conserved protein [Function unknown]; Region: COG4121 63737002415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002416 Response regulator receiver domain; Region: Response_reg; pfam00072 63737002417 active site 63737002418 phosphorylation site [posttranslational modification] 63737002419 intermolecular recognition site; other site 63737002420 dimerization interface [polypeptide binding]; other site 63737002421 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 63737002422 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 63737002423 Zn2+ binding site [ion binding]; other site 63737002424 Mg2+ binding site [ion binding]; other site 63737002425 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 63737002426 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 63737002427 Substrate binding site; other site 63737002428 Mg++ binding site; other site 63737002429 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 63737002430 active site 63737002431 substrate binding site [chemical binding]; other site 63737002432 CoA binding site [chemical binding]; other site 63737002433 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737002434 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 63737002435 active site 63737002436 dimer interface [polypeptide binding]; other site 63737002437 catalytic nucleophile [active] 63737002438 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 63737002439 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002440 GAF domain; Region: GAF; cl17456 63737002441 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002442 GAF domain; Region: GAF; pfam01590 63737002443 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002444 GAF domain; Region: GAF_3; pfam13492 63737002445 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 63737002446 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 63737002447 quinone interaction residues [chemical binding]; other site 63737002448 active site 63737002449 catalytic residues [active] 63737002450 FMN binding site [chemical binding]; other site 63737002451 substrate binding site [chemical binding]; other site 63737002452 TROVE domain; Region: TROVE; pfam05731 63737002453 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 63737002454 metal ion-dependent adhesion site (MIDAS); other site 63737002455 AAA ATPase domain; Region: AAA_16; pfam13191 63737002456 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737002457 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737002458 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737002459 AAA ATPase domain; Region: AAA_16; pfam13191 63737002460 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737002461 glutathione reductase; Validated; Region: PRK06116 63737002462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737002463 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737002464 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737002465 Uncharacterized conserved protein [Function unknown]; Region: COG1432 63737002466 LabA_like proteins; Region: LabA; cd10911 63737002467 putative metal binding site [ion binding]; other site 63737002468 2-isopropylmalate synthase; Validated; Region: PRK00915 63737002469 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 63737002470 active site 63737002471 catalytic residues [active] 63737002472 metal binding site [ion binding]; metal-binding site 63737002473 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 63737002474 HEAT repeats; Region: HEAT_2; pfam13646 63737002475 HEAT repeats; Region: HEAT_2; pfam13646 63737002476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737002477 Coenzyme A binding pocket [chemical binding]; other site 63737002478 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 63737002479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737002480 ATP binding site [chemical binding]; other site 63737002481 putative Mg++ binding site [ion binding]; other site 63737002482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737002483 nucleotide binding region [chemical binding]; other site 63737002484 ATP-binding site [chemical binding]; other site 63737002485 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 63737002486 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737002487 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737002488 putative active site [active] 63737002489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 63737002490 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 63737002491 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 63737002492 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 63737002493 dimer interface [polypeptide binding]; other site 63737002494 motif 1; other site 63737002495 active site 63737002496 motif 2; other site 63737002497 motif 3; other site 63737002498 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 63737002499 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 63737002500 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 63737002501 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 63737002502 active site 63737002503 Riboflavin kinase; Region: Flavokinase; smart00904 63737002504 MoxR-like ATPases [General function prediction only]; Region: COG0714 63737002505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737002506 ATP binding site [chemical binding]; other site 63737002507 Walker A motif; other site 63737002508 Walker B motif; other site 63737002509 arginine finger; other site 63737002510 cytochrome c-550; Provisional; Region: psbV; cl17239 63737002511 Dihaem cytochrome c; Region: DHC; pfam09626 63737002512 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 63737002513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 63737002514 ATP binding site [chemical binding]; other site 63737002515 putative Mg++ binding site [ion binding]; other site 63737002516 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 63737002517 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 63737002518 inhibitor binding site; inhibition site 63737002519 catalytic motif [active] 63737002520 Catalytic residue [active] 63737002521 Active site flap [active] 63737002522 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 63737002523 active site 63737002524 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 63737002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737002526 S-adenosylmethionine binding site [chemical binding]; other site 63737002527 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 63737002528 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 63737002529 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 63737002530 active site 63737002531 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 63737002532 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737002533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737002534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002535 active site 63737002536 phosphorylation site [posttranslational modification] 63737002537 intermolecular recognition site; other site 63737002538 dimerization interface [polypeptide binding]; other site 63737002539 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737002540 DNA binding residues [nucleotide binding] 63737002541 dimerization interface [polypeptide binding]; other site 63737002542 Response regulator receiver domain; Region: Response_reg; pfam00072 63737002543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002544 active site 63737002545 phosphorylation site [posttranslational modification] 63737002546 intermolecular recognition site; other site 63737002547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002548 dimerization interface [polypeptide binding]; other site 63737002549 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 63737002550 dimer interface [polypeptide binding]; other site 63737002551 phosphorylation site [posttranslational modification] 63737002552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002553 ATP binding site [chemical binding]; other site 63737002554 Mg2+ binding site [ion binding]; other site 63737002555 G-X-G motif; other site 63737002556 CsbD-like; Region: CsbD; cl17424 63737002557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737002558 TPR motif; other site 63737002559 binding surface 63737002560 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 63737002561 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 63737002562 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 63737002563 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737002564 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737002565 active site 63737002566 ATP binding site [chemical binding]; other site 63737002567 substrate binding site [chemical binding]; other site 63737002568 activation loop (A-loop); other site 63737002569 AAA ATPase domain; Region: AAA_16; pfam13191 63737002570 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737002571 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737002572 structural tetrad; other site 63737002573 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737002574 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737002575 structural tetrad; other site 63737002576 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 63737002577 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002578 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737002579 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002580 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002581 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 63737002582 amidohydrolase; Region: amidohydrolases; TIGR01891 63737002583 metal binding site [ion binding]; metal-binding site 63737002584 dimer interface [polypeptide binding]; other site 63737002585 Hemerythrin-like domain; Region: Hr-like; cd12108 63737002586 Fe binding site [ion binding]; other site 63737002587 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 63737002588 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 63737002589 putative ligand binding site [chemical binding]; other site 63737002590 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737002591 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737002592 active site 63737002593 ATP binding site [chemical binding]; other site 63737002594 substrate binding site [chemical binding]; other site 63737002595 activation loop (A-loop); other site 63737002596 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 63737002597 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 63737002598 G1 box; other site 63737002599 putative GEF interaction site [polypeptide binding]; other site 63737002600 GTP/Mg2+ binding site [chemical binding]; other site 63737002601 Switch I region; other site 63737002602 G2 box; other site 63737002603 G3 box; other site 63737002604 Switch II region; other site 63737002605 G4 box; other site 63737002606 G5 box; other site 63737002607 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 63737002608 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 63737002609 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 63737002610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 63737002611 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 63737002612 arogenate dehydrogenase; Reviewed; Region: PRK07417 63737002613 prephenate dehydrogenase; Validated; Region: PRK08507 63737002614 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737002615 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002616 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002617 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002618 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002619 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002620 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002621 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 63737002622 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737002623 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 63737002624 HSP70 interaction site [polypeptide binding]; other site 63737002625 Clp protease; Region: CLP_protease; pfam00574 63737002626 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 63737002627 oligomer interface [polypeptide binding]; other site 63737002628 active site residues [active] 63737002629 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 63737002630 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 63737002631 oligomer interface [polypeptide binding]; other site 63737002632 active site residues [active] 63737002633 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 63737002634 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 63737002635 metal ion-dependent adhesion site (MIDAS); other site 63737002636 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 63737002637 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 63737002638 metal ion-dependent adhesion site (MIDAS); other site 63737002639 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 63737002640 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 63737002641 NodB motif; other site 63737002642 active site 63737002643 catalytic site [active] 63737002644 metal binding site [ion binding]; metal-binding site 63737002645 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 63737002646 Family of unknown function (DUF490); Region: DUF490; pfam04357 63737002647 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 63737002648 Family of unknown function (DUF490); Region: DUF490; pfam04357 63737002649 Family of unknown function (DUF490); Region: DUF490; pfam04357 63737002650 lipoyl synthase; Provisional; Region: PRK05481 63737002651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 63737002652 FeS/SAM binding site; other site 63737002653 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 63737002654 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 63737002655 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 63737002656 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 63737002657 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737002658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737002659 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737002660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737002661 DNA binding residues [nucleotide binding] 63737002662 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 63737002663 metal binding site 2 [ion binding]; metal-binding site 63737002664 putative DNA binding helix; other site 63737002665 metal binding site 1 [ion binding]; metal-binding site 63737002666 dimer interface [polypeptide binding]; other site 63737002667 structural Zn2+ binding site [ion binding]; other site 63737002668 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737002669 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737002670 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737002671 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737002672 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737002673 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737002674 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737002675 CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514 63737002676 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737002677 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737002678 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002679 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737002680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737002682 dimer interface [polypeptide binding]; other site 63737002683 phosphorylation site [posttranslational modification] 63737002684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002685 ATP binding site [chemical binding]; other site 63737002686 Mg2+ binding site [ion binding]; other site 63737002687 G-X-G motif; other site 63737002688 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 63737002689 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737002690 Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378 63737002691 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 63737002692 active site 63737002693 metal binding site [ion binding]; metal-binding site 63737002694 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737002695 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 63737002696 apolar tunnel; other site 63737002697 heme binding site [chemical binding]; other site 63737002698 dimerization interface [polypeptide binding]; other site 63737002699 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 63737002700 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 63737002701 Part of AAA domain; Region: AAA_19; pfam13245 63737002702 Family description; Region: UvrD_C_2; pfam13538 63737002703 Domain of unknown function (DUF897); Region: DUF897; pfam05982 63737002704 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 63737002705 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 63737002706 active site clefts [active] 63737002707 zinc binding site [ion binding]; other site 63737002708 dimer interface [polypeptide binding]; other site 63737002709 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737002711 dimerization interface [polypeptide binding]; other site 63737002712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737002713 dimer interface [polypeptide binding]; other site 63737002714 phosphorylation site [posttranslational modification] 63737002715 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002716 ATP binding site [chemical binding]; other site 63737002717 Mg2+ binding site [ion binding]; other site 63737002718 G-X-G motif; other site 63737002719 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 63737002720 S-layer homology domain; Region: SLH; pfam00395 63737002721 S-layer homology domain; Region: SLH; pfam00395 63737002722 S-layer homology domain; Region: SLH; pfam00395 63737002723 Putative restriction endonuclease; Region: Uma2; pfam05685 63737002724 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 63737002725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002727 ATP binding site [chemical binding]; other site 63737002728 Mg2+ binding site [ion binding]; other site 63737002729 G-X-G motif; other site 63737002730 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 63737002731 active site 63737002732 catalytic site [active] 63737002733 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737002734 classical (c) SDRs; Region: SDR_c; cd05233 63737002735 NAD(P) binding site [chemical binding]; other site 63737002736 active site 63737002737 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737002738 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 63737002739 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737002740 putative active site [active] 63737002741 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 63737002742 protein I interface; other site 63737002743 D2 interface; other site 63737002744 protein T interface; other site 63737002745 chlorophyll binding site; other site 63737002746 beta carotene binding site; other site 63737002747 pheophytin binding site; other site 63737002748 manganese-stabilizing polypeptide interface; other site 63737002749 CP43 interface; other site 63737002750 protein L interface; other site 63737002751 oxygen evolving complex binding site; other site 63737002752 bromide binding site; other site 63737002753 quinone binding site; other site 63737002754 Fe binding site [ion binding]; other site 63737002755 core light harvesting interface; other site 63737002756 cytochrome b559 alpha subunit interface; other site 63737002757 cytochrome c-550 interface; other site 63737002758 protein J interface; other site 63737002759 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 63737002760 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 63737002761 Malic enzyme, N-terminal domain; Region: malic; pfam00390 63737002762 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 63737002763 putative NAD(P) binding site [chemical binding]; other site 63737002764 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737002765 metal binding site [ion binding]; metal-binding site 63737002766 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 63737002767 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737002768 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 63737002769 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 63737002770 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 63737002771 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 63737002772 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 63737002773 active site 63737002774 catalytic site [active] 63737002775 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 63737002776 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 63737002777 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737002778 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737002779 acylphosphatase; Provisional; Region: PRK14423 63737002780 light-harvesting-like protein 3; Provisional; Region: PLN00014 63737002781 sensory histidine kinase AtoS; Provisional; Region: PRK11360 63737002782 nitrogenase reductase; Reviewed; Region: PRK13236 63737002783 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 63737002784 Nucleotide-binding sites [chemical binding]; other site 63737002785 Walker A motif; other site 63737002786 Switch I region of nucleotide binding site; other site 63737002787 Fe4S4 binding sites [ion binding]; other site 63737002788 Switch II region of nucleotide binding site; other site 63737002789 Uncharacterized conserved protein [Function unknown]; Region: COG1801 63737002790 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 63737002791 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737002792 HSP70 interaction site [polypeptide binding]; other site 63737002793 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002794 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737002795 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002796 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002797 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737002798 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 63737002799 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 63737002800 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737002801 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737002802 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737002803 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 63737002804 Protein export membrane protein; Region: SecD_SecF; cl14618 63737002805 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 63737002806 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737002807 putative di-iron ligands [ion binding]; other site 63737002808 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 63737002809 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 63737002810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737002811 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 63737002812 XisI protein; Region: XisI; pfam08869 63737002813 DNA methylase; Region: N6_N4_Mtase; pfam01555 63737002814 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 63737002815 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 63737002816 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 63737002817 homotetramer interface [polypeptide binding]; other site 63737002818 ligand binding site [chemical binding]; other site 63737002819 catalytic site [active] 63737002820 NAD binding site [chemical binding]; other site 63737002821 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 63737002822 Mechanosensitive ion channel; Region: MS_channel; pfam00924 63737002823 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 63737002824 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 63737002825 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737002826 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 63737002827 Mechanosensitive ion channel; Region: MS_channel; pfam00924 63737002828 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737002829 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737002830 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737002831 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737002832 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737002833 metal binding site [ion binding]; metal-binding site 63737002834 active site 63737002835 I-site; other site 63737002836 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737002837 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 63737002838 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 63737002839 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737002840 active site 63737002841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737002842 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737002843 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 63737002844 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737002845 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 63737002846 active site 63737002847 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 63737002848 putative ADP-binding pocket [chemical binding]; other site 63737002849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737002850 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737002851 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737002852 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 63737002853 Walker A/P-loop; other site 63737002854 ATP binding site [chemical binding]; other site 63737002855 Q-loop/lid; other site 63737002856 ABC transporter signature motif; other site 63737002857 Walker B; other site 63737002858 D-loop; other site 63737002859 H-loop/switch region; other site 63737002860 Bacterial sugar transferase; Region: Bac_transf; cl00939 63737002861 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737002862 Chain length determinant protein; Region: Wzz; pfam02706 63737002863 AAA domain; Region: AAA_31; pfam13614 63737002864 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737002865 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 63737002866 putative ADP-binding pocket [chemical binding]; other site 63737002867 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 63737002868 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737002869 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 63737002870 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737002871 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737002872 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 63737002873 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 63737002874 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737002875 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737002876 active site 63737002877 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 63737002878 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737002879 Methyltransferase domain; Region: Methyltransf_12; pfam08242 63737002880 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 63737002881 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 63737002882 extended (e) SDRs; Region: SDR_e; cd08946 63737002883 NAD(P) binding site [chemical binding]; other site 63737002884 active site 63737002885 substrate binding site [chemical binding]; other site 63737002886 Predicted dehydrogenase [General function prediction only]; Region: COG0579 63737002887 hydroxyglutarate oxidase; Provisional; Region: PRK11728 63737002888 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 63737002889 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 63737002890 substrate binding site; other site 63737002891 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 63737002892 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 63737002893 substrate binding site [chemical binding]; other site 63737002894 activation loop (A-loop); other site 63737002895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737002896 binding surface 63737002897 TPR repeat; Region: TPR_11; pfam13414 63737002898 TPR motif; other site 63737002899 TPR repeat; Region: TPR_11; pfam13414 63737002900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737002901 binding surface 63737002902 TPR motif; other site 63737002903 TPR repeat; Region: TPR_11; pfam13414 63737002904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737002905 binding surface 63737002906 TPR motif; other site 63737002907 Protein phosphatase 2C; Region: PP2C_2; pfam13672 63737002908 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 63737002909 metal ion-dependent adhesion site (MIDAS); other site 63737002910 Response regulator receiver domain; Region: Response_reg; pfam00072 63737002911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002912 active site 63737002913 phosphorylation site [posttranslational modification] 63737002914 intermolecular recognition site; other site 63737002915 dimerization interface [polypeptide binding]; other site 63737002916 Response regulator receiver domain; Region: Response_reg; pfam00072 63737002917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002918 active site 63737002919 phosphorylation site [posttranslational modification] 63737002920 intermolecular recognition site; other site 63737002921 dimerization interface [polypeptide binding]; other site 63737002922 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 63737002923 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 63737002924 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 63737002925 putative tRNA-binding site [nucleotide binding]; other site 63737002926 B3/4 domain; Region: B3_4; pfam03483 63737002927 tRNA synthetase B5 domain; Region: B5; smart00874 63737002928 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 63737002929 dimer interface [polypeptide binding]; other site 63737002930 motif 1; other site 63737002931 motif 3; other site 63737002932 motif 2; other site 63737002933 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 63737002934 YciI-like protein; Reviewed; Region: PRK12864 63737002935 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 63737002936 PemK-like protein; Region: PemK; pfam02452 63737002937 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 63737002938 phage tail protein domain; Region: tail_TIGR02242 63737002939 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 63737002940 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 63737002941 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 63737002942 PAAR motif; Region: PAAR_motif; pfam05488 63737002943 Phage protein D [General function prediction only]; Region: COG3500 63737002944 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 63737002945 ribonuclease E; Reviewed; Region: rne; PRK10811 63737002946 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 63737002947 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 63737002948 XisI protein; Region: XisI; pfam08869 63737002949 XisH protein; Region: XisH; pfam08814 63737002950 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 63737002951 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737002952 phosphopeptide binding site; other site 63737002953 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 63737002954 active site 63737002955 ATP binding site [chemical binding]; other site 63737002956 substrate binding site [chemical binding]; other site 63737002957 PBP superfamily domain; Region: PBP_like_2; cl17296 63737002958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737002959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737002960 active site 63737002961 phosphorylation site [posttranslational modification] 63737002962 intermolecular recognition site; other site 63737002963 dimerization interface [polypeptide binding]; other site 63737002964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737002965 DNA binding residues [nucleotide binding] 63737002966 dimerization interface [polypeptide binding]; other site 63737002967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737002968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737002969 ATP binding site [chemical binding]; other site 63737002970 Mg2+ binding site [ion binding]; other site 63737002971 G-X-G motif; other site 63737002972 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 63737002973 Cna protein B-type domain; Region: Cna_B_2; pfam13715 63737002974 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 63737002975 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 63737002976 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 63737002977 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 63737002978 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737002979 phosphopeptide binding site; other site 63737002980 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 63737002981 active site 63737002982 dimer interfaces [polypeptide binding]; other site 63737002983 catalytic residues [active] 63737002984 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737002985 CHASE2 domain; Region: CHASE2; pfam05226 63737002986 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737002987 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737002988 active site 63737002989 ATP binding site [chemical binding]; other site 63737002990 substrate binding site [chemical binding]; other site 63737002991 activation loop (A-loop); other site 63737002992 MOSC domain; Region: MOSC; pfam03473 63737002993 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 63737002994 DNA binding site [nucleotide binding] 63737002995 active site 63737002996 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 63737002997 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 63737002998 tetramer (dimer of dimers) interface [polypeptide binding]; other site 63737002999 active site 63737003000 dimer interface [polypeptide binding]; other site 63737003001 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737003002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003003 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 63737003004 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737003005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003006 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003007 S-layer homology domain; Region: SLH; pfam00395 63737003008 S-layer homology domain; Region: SLH; pfam00395 63737003009 FOG: CBS domain [General function prediction only]; Region: COG0517 63737003010 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 63737003011 CP12 domain; Region: CP12; pfam02672 63737003012 Predicted permeases [General function prediction only]; Region: COG0795 63737003013 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 63737003014 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 63737003015 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 63737003016 Walker A/P-loop; other site 63737003017 ATP binding site [chemical binding]; other site 63737003018 Q-loop/lid; other site 63737003019 ABC transporter signature motif; other site 63737003020 Walker B; other site 63737003021 D-loop; other site 63737003022 H-loop/switch region; other site 63737003023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 63737003024 OstA-like protein; Region: OstA; pfam03968 63737003025 Domain of unknown function (DUF309); Region: DUF309; pfam03745 63737003026 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 63737003027 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 63737003028 Protein of unknown function DUF58; Region: DUF58; pfam01882 63737003029 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 63737003030 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 63737003031 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 63737003032 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 63737003033 Phosphoesterase family; Region: Phosphoesterase; pfam04185 63737003034 S-layer homology domain; Region: SLH; pfam00395 63737003035 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737003036 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 63737003037 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 63737003038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737003039 putative metal binding site [ion binding]; other site 63737003040 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737003041 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 63737003042 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 63737003043 putative active site [active] 63737003044 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 63737003045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737003046 FeS/SAM binding site; other site 63737003047 HemN C-terminal domain; Region: HemN_C; pfam06969 63737003048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737003049 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 63737003050 active site 63737003051 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 63737003052 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 63737003053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737003054 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 63737003055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737003056 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 63737003057 dimer interface [polypeptide binding]; other site 63737003058 catalytic triad [active] 63737003059 KGK domain; Region: KGK; pfam08872 63737003060 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 63737003061 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737003062 G1 box; other site 63737003063 GTP/Mg2+ binding site [chemical binding]; other site 63737003064 G2 box; other site 63737003065 Switch I region; other site 63737003066 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737003067 G3 box; other site 63737003068 Switch II region; other site 63737003069 GTP/Mg2+ binding site [chemical binding]; other site 63737003070 G4 box; other site 63737003071 G5 box; other site 63737003072 HPP family; Region: HPP; pfam04982 63737003073 CpeS-like protein; Region: CpeS; pfam09367 63737003074 HEAT repeats; Region: HEAT_2; pfam13646 63737003075 HEAT repeats; Region: HEAT_2; pfam13646 63737003076 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 63737003077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 63737003078 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737003079 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737003080 catalytic loop [active] 63737003081 iron binding site [ion binding]; other site 63737003082 Staphylococcal nuclease homologues; Region: SNc; smart00318 63737003083 Catalytic site; other site 63737003084 Staphylococcal nuclease homologue; Region: SNase; pfam00565 63737003085 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 63737003086 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 63737003087 active site 63737003088 dimerization interface [polypeptide binding]; other site 63737003089 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 63737003090 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737003091 HSP70 interaction site [polypeptide binding]; other site 63737003092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737003093 binding surface 63737003094 TPR motif; other site 63737003095 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 63737003096 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 63737003097 dimer interface [polypeptide binding]; other site 63737003098 motif 1; other site 63737003099 active site 63737003100 motif 2; other site 63737003101 motif 3; other site 63737003102 PIN domain; Region: PIN_3; cl17397 63737003103 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 63737003104 oligomeric interface; other site 63737003105 putative active site [active] 63737003106 homodimer interface [polypeptide binding]; other site 63737003107 GUN4-like; Region: GUN4; pfam05419 63737003108 Ferredoxin [Energy production and conversion]; Region: COG1146 63737003109 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 63737003110 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 63737003111 Walker A/P-loop; other site 63737003112 ATP binding site [chemical binding]; other site 63737003113 Q-loop/lid; other site 63737003114 ABC transporter signature motif; other site 63737003115 Walker B; other site 63737003116 D-loop; other site 63737003117 H-loop/switch region; other site 63737003118 cytochrome c6; Provisional; Region: PRK13697 63737003119 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 63737003120 TPR repeat; Region: TPR_11; pfam13414 63737003121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737003122 binding surface 63737003123 TPR motif; other site 63737003124 TPR repeat; Region: TPR_11; pfam13414 63737003125 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737003126 TPR repeat; Region: TPR_11; pfam13414 63737003127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737003128 binding surface 63737003129 TPR motif; other site 63737003130 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737003131 putative active site [active] 63737003132 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 63737003133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 63737003134 N-terminal plug; other site 63737003135 ligand-binding site [chemical binding]; other site 63737003136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737003137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 63737003138 Coenzyme A binding pocket [chemical binding]; other site 63737003139 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 63737003140 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 63737003141 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 63737003142 dimerization domain swap beta strand [polypeptide binding]; other site 63737003143 regulatory protein interface [polypeptide binding]; other site 63737003144 active site 63737003145 regulatory phosphorylation site [posttranslational modification]; other site 63737003146 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 63737003147 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 63737003148 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 63737003149 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 63737003150 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 63737003151 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 63737003152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 63737003153 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 63737003154 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 63737003155 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 63737003156 EamA-like transporter family; Region: EamA; pfam00892 63737003157 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737003158 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 63737003159 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737003160 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 63737003161 GAF domain; Region: GAF; pfam01590 63737003162 Phytochrome region; Region: PHY; pfam00360 63737003163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003164 dimer interface [polypeptide binding]; other site 63737003165 phosphorylation site [posttranslational modification] 63737003166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003167 ATP binding site [chemical binding]; other site 63737003168 Mg2+ binding site [ion binding]; other site 63737003169 G-X-G motif; other site 63737003170 Response regulator receiver domain; Region: Response_reg; pfam00072 63737003171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003172 active site 63737003173 phosphorylation site [posttranslational modification] 63737003174 intermolecular recognition site; other site 63737003175 dimerization interface [polypeptide binding]; other site 63737003176 Response regulator receiver domain; Region: Response_reg; pfam00072 63737003177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003178 active site 63737003179 phosphorylation site [posttranslational modification] 63737003180 intermolecular recognition site; other site 63737003181 dimerization interface [polypeptide binding]; other site 63737003182 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737003183 GAF domain; Region: GAF; pfam01590 63737003184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737003186 dimer interface [polypeptide binding]; other site 63737003187 phosphorylation site [posttranslational modification] 63737003188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003189 ATP binding site [chemical binding]; other site 63737003190 Mg2+ binding site [ion binding]; other site 63737003191 G-X-G motif; other site 63737003192 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 63737003193 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 63737003194 RNA binding site [nucleotide binding]; other site 63737003195 active site 63737003196 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 63737003197 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737003198 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 63737003199 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 63737003200 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 63737003201 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 63737003202 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 63737003203 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 63737003204 active site 63737003205 metal binding site [ion binding]; metal-binding site 63737003206 dimerization interface [polypeptide binding]; other site 63737003207 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737003208 anti sigma factor interaction site; other site 63737003209 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 63737003210 regulatory phosphorylation site [posttranslational modification]; other site 63737003211 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 63737003212 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 63737003213 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 63737003214 catalytic site [active] 63737003215 subunit interface [polypeptide binding]; other site 63737003216 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 63737003217 catalytic motif [active] 63737003218 Catalytic residue [active] 63737003219 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 63737003220 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 63737003221 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 63737003222 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 63737003223 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 63737003224 putative high light inducible protein; Region: PHA02337 63737003225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 63737003226 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 63737003227 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737003228 G1 box; other site 63737003229 GTP/Mg2+ binding site [chemical binding]; other site 63737003230 G2 box; other site 63737003231 PAS fold; Region: PAS_3; pfam08447 63737003232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737003233 heme pocket [chemical binding]; other site 63737003234 putative active site [active] 63737003235 PAS fold; Region: PAS_4; pfam08448 63737003236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737003237 putative active site [active] 63737003238 heme pocket [chemical binding]; other site 63737003239 PAS domain S-box; Region: sensory_box; TIGR00229 63737003240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737003241 putative active site [active] 63737003242 heme pocket [chemical binding]; other site 63737003243 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737003244 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737003245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737003246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003247 dimer interface [polypeptide binding]; other site 63737003248 phosphorylation site [posttranslational modification] 63737003249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003250 ATP binding site [chemical binding]; other site 63737003251 Mg2+ binding site [ion binding]; other site 63737003252 G-X-G motif; other site 63737003253 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 63737003254 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 63737003255 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 63737003256 NAD binding site [chemical binding]; other site 63737003257 catalytic residues [active] 63737003258 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 63737003259 metal ion-dependent adhesion site (MIDAS); other site 63737003260 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 63737003261 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737003262 substrate binding pocket [chemical binding]; other site 63737003263 membrane-bound complex binding site; other site 63737003264 hinge residues; other site 63737003265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737003266 dimerization interface [polypeptide binding]; other site 63737003267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003268 dimer interface [polypeptide binding]; other site 63737003269 phosphorylation site [posttranslational modification] 63737003270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003271 ATP binding site [chemical binding]; other site 63737003272 Mg2+ binding site [ion binding]; other site 63737003273 G-X-G motif; other site 63737003274 Response regulator receiver domain; Region: Response_reg; pfam00072 63737003275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003276 active site 63737003277 phosphorylation site [posttranslational modification] 63737003278 intermolecular recognition site; other site 63737003279 dimerization interface [polypeptide binding]; other site 63737003280 Response regulator receiver domain; Region: Response_reg; pfam00072 63737003281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003282 active site 63737003283 phosphorylation site [posttranslational modification] 63737003284 intermolecular recognition site; other site 63737003285 dimerization interface [polypeptide binding]; other site 63737003286 Response regulator receiver domain; Region: Response_reg; pfam00072 63737003287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003288 active site 63737003289 phosphorylation site [posttranslational modification] 63737003290 intermolecular recognition site; other site 63737003291 dimerization interface [polypeptide binding]; other site 63737003292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003293 dimer interface [polypeptide binding]; other site 63737003294 phosphorylation site [posttranslational modification] 63737003295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003296 ATP binding site [chemical binding]; other site 63737003297 Mg2+ binding site [ion binding]; other site 63737003298 G-X-G motif; other site 63737003299 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 63737003300 Leucine-rich repeats; other site 63737003301 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 63737003302 Substrate binding site [chemical binding]; other site 63737003303 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737003304 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 63737003305 Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914 63737003306 G1 box; other site 63737003307 GTP/Mg2+ binding site [chemical binding]; other site 63737003308 G2 box; other site 63737003309 Switch I region; other site 63737003310 G3 box; other site 63737003311 Switch II region; other site 63737003312 G4 box; other site 63737003313 G5 box; other site 63737003314 TIR domain; Region: TIR_2; pfam13676 63737003315 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 63737003316 dimer interface [polypeptide binding]; other site 63737003317 putative metal binding site [ion binding]; other site 63737003318 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737003319 Dienelactone hydrolase family; Region: DLH; pfam01738 63737003320 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 63737003321 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 63737003322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737003323 substrate binding pocket [chemical binding]; other site 63737003324 membrane-bound complex binding site; other site 63737003325 hinge residues; other site 63737003326 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737003327 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737003328 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737003329 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737003330 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737003331 active site 63737003332 haemagglutination activity domain; Region: Haemagg_act; pfam05860 63737003333 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737003334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 63737003335 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 63737003336 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737003337 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737003338 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003339 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737003340 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003341 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003342 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003343 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737003344 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737003345 AAA ATPase domain; Region: AAA_16; pfam13191 63737003346 WD domain, G-beta repeat; Region: WD40; pfam00400 63737003347 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737003348 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737003349 structural tetrad; other site 63737003350 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737003351 structural tetrad; other site 63737003352 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737003353 WD domain, G-beta repeat; Region: WD40; pfam00400 63737003354 WD40 repeats; Region: WD40; smart00320 63737003355 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 63737003356 hypothetical protein; Validated; Region: PRK07413 63737003357 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 63737003358 homodimer interface [polypeptide binding]; other site 63737003359 Walker A motif; other site 63737003360 ATP binding site [chemical binding]; other site 63737003361 hydroxycobalamin binding site [chemical binding]; other site 63737003362 Walker B motif; other site 63737003363 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 63737003364 Walker A motif; other site 63737003365 homodimer interface [polypeptide binding]; other site 63737003366 ATP binding site [chemical binding]; other site 63737003367 hydroxycobalamin binding site [chemical binding]; other site 63737003368 Walker B motif; other site 63737003369 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 63737003370 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 63737003371 Mg++ binding site [ion binding]; other site 63737003372 putative catalytic motif [active] 63737003373 substrate binding site [chemical binding]; other site 63737003374 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 63737003375 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 63737003376 ring oligomerisation interface [polypeptide binding]; other site 63737003377 ATP/Mg binding site [chemical binding]; other site 63737003378 stacking interactions; other site 63737003379 hinge regions; other site 63737003380 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 63737003381 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 63737003382 oligomer interface [polypeptide binding]; other site 63737003383 metal binding site [ion binding]; metal-binding site 63737003384 metal binding site [ion binding]; metal-binding site 63737003385 Cl binding site [ion binding]; other site 63737003386 aspartate ring; other site 63737003387 basic sphincter; other site 63737003388 putative hydrophobic gate; other site 63737003389 periplasmic entrance; other site 63737003390 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 63737003391 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 63737003392 dimerization interface [polypeptide binding]; other site 63737003393 active site 63737003394 metal binding site [ion binding]; metal-binding site 63737003395 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 63737003396 dsRNA binding site [nucleotide binding]; other site 63737003397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737003398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737003399 Tetratricopeptide repeat; Region: TPR_1; pfam00515 63737003400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 63737003401 dimerization interface [polypeptide binding]; other site 63737003402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003403 dimer interface [polypeptide binding]; other site 63737003404 phosphorylation site [posttranslational modification] 63737003405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003406 ATP binding site [chemical binding]; other site 63737003407 Mg2+ binding site [ion binding]; other site 63737003408 G-X-G motif; other site 63737003409 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 63737003410 RibD C-terminal domain; Region: RibD_C; cl17279 63737003411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 63737003412 Protein of unknown function, DUF482; Region: DUF482; pfam04339 63737003413 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 63737003414 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 63737003415 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 63737003416 Repair protein; Region: Repair_PSII; pfam04536 63737003417 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 63737003418 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 63737003419 tandem repeat interface [polypeptide binding]; other site 63737003420 oligomer interface [polypeptide binding]; other site 63737003421 active site residues [active] 63737003422 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 63737003423 tandem repeat interface [polypeptide binding]; other site 63737003424 oligomer interface [polypeptide binding]; other site 63737003425 active site residues [active] 63737003426 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 63737003427 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 63737003428 homotetramer interface [polypeptide binding]; other site 63737003429 FMN binding site [chemical binding]; other site 63737003430 homodimer contacts [polypeptide binding]; other site 63737003431 putative active site [active] 63737003432 putative substrate binding site [chemical binding]; other site 63737003433 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737003434 putative active site [active] 63737003435 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 63737003436 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 63737003437 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 63737003438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 63737003439 acyl-activating enzyme (AAE) consensus motif; other site 63737003440 CoA binding site [chemical binding]; other site 63737003441 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737003442 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737003443 active site 63737003444 ATP binding site [chemical binding]; other site 63737003445 substrate binding site [chemical binding]; other site 63737003446 activation loop (A-loop); other site 63737003447 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 63737003448 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737003449 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737003450 active site 63737003451 ATP binding site [chemical binding]; other site 63737003452 substrate binding site [chemical binding]; other site 63737003453 activation loop (A-loop); other site 63737003454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 63737003455 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 63737003456 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 63737003457 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 63737003458 tetramer interface [polypeptide binding]; other site 63737003459 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737003460 catalytic residue [active] 63737003461 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737003462 classical (c) SDRs; Region: SDR_c; cd05233 63737003463 NAD(P) binding site [chemical binding]; other site 63737003464 active site 63737003465 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 63737003466 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 63737003467 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 63737003468 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 63737003469 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 63737003470 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 63737003471 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 63737003472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737003473 catalytic residue [active] 63737003474 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 63737003475 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 63737003476 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 63737003477 substrate binding site [chemical binding]; other site 63737003478 active site 63737003479 catalytic residues [active] 63737003480 heterodimer interface [polypeptide binding]; other site 63737003481 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 63737003482 active site 63737003483 ribulose/triose binding site [chemical binding]; other site 63737003484 phosphate binding site [ion binding]; other site 63737003485 substrate (anthranilate) binding pocket [chemical binding]; other site 63737003486 product (indole) binding pocket [chemical binding]; other site 63737003487 anthranilate synthase; Provisional; Region: PRK13566 63737003488 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 63737003489 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 63737003490 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 63737003491 glutamine binding [chemical binding]; other site 63737003492 catalytic triad [active] 63737003493 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 63737003494 active site 63737003495 metal binding site [ion binding]; metal-binding site 63737003496 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 63737003497 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 63737003498 catalytic residues [active] 63737003499 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 63737003500 prephenate dehydrogenase; Provisional; Region: PRK06444 63737003501 putative glycosyl transferase; Provisional; Region: PRK10307 63737003502 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 63737003503 Uncharacterized conserved protein [Function unknown]; Region: COG3391 63737003504 NHL repeat; Region: NHL; pfam01436 63737003505 NHL repeat; Region: NHL; pfam01436 63737003506 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 63737003507 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 63737003508 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 63737003509 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 63737003510 NAD binding site [chemical binding]; other site 63737003511 Phe binding site; other site 63737003512 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 63737003513 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737003514 PYR/PP interface [polypeptide binding]; other site 63737003515 dimer interface [polypeptide binding]; other site 63737003516 TPP binding site [chemical binding]; other site 63737003517 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737003518 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 63737003519 TPP-binding site [chemical binding]; other site 63737003520 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737003521 PAS domain; Region: PAS_9; pfam13426 63737003522 putative active site [active] 63737003523 heme pocket [chemical binding]; other site 63737003524 PAS domain; Region: PAS_9; pfam13426 63737003525 PAS domain S-box; Region: sensory_box; TIGR00229 63737003526 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 63737003527 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737003528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003529 dimer interface [polypeptide binding]; other site 63737003530 phosphorylation site [posttranslational modification] 63737003531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003532 ATP binding site [chemical binding]; other site 63737003533 Mg2+ binding site [ion binding]; other site 63737003534 G-X-G motif; other site 63737003535 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737003536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003537 active site 63737003538 phosphorylation site [posttranslational modification] 63737003539 intermolecular recognition site; other site 63737003540 dimerization interface [polypeptide binding]; other site 63737003541 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 63737003542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737003543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737003544 AAA domain; Region: AAA_18; pfam13238 63737003545 Walker A motif; other site 63737003546 ATP binding site [chemical binding]; other site 63737003547 Walker B motif; other site 63737003548 arginine finger; other site 63737003549 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 63737003550 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737003551 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 63737003552 Walker A/P-loop; other site 63737003553 ATP binding site [chemical binding]; other site 63737003554 Q-loop/lid; other site 63737003555 ABC transporter signature motif; other site 63737003556 Walker B; other site 63737003557 D-loop; other site 63737003558 H-loop/switch region; other site 63737003559 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737003560 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 63737003561 Alcohol acetyltransferase; Region: AATase; pfam07247 63737003562 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737003563 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737003564 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737003565 catalytic loop [active] 63737003566 iron binding site [ion binding]; other site 63737003567 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 63737003568 FMN binding site [chemical binding]; other site 63737003569 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 63737003570 substrate binding site [chemical binding]; other site 63737003571 putative catalytic residue [active] 63737003572 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737003573 active site 63737003574 Acyl transferase domain; Region: Acyl_transf_1; cl08282 63737003575 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737003576 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737003577 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 63737003578 active site 63737003579 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737003580 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737003581 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 63737003582 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 63737003583 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 63737003584 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737003585 putative NADP binding site [chemical binding]; other site 63737003586 active site 63737003587 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737003588 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737003589 DevC protein; Region: devC; TIGR01185 63737003590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737003591 FtsX-like permease family; Region: FtsX; pfam02687 63737003592 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 63737003593 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737003594 Walker A/P-loop; other site 63737003595 ATP binding site [chemical binding]; other site 63737003596 Q-loop/lid; other site 63737003597 ABC transporter signature motif; other site 63737003598 Walker B; other site 63737003599 D-loop; other site 63737003600 H-loop/switch region; other site 63737003601 TrkA-N domain; Region: TrkA_N; pfam02254 63737003602 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 63737003603 TrkA-N domain; Region: TrkA_N; pfam02254 63737003604 TrkA-C domain; Region: TrkA_C; pfam02080 63737003605 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 63737003606 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 63737003607 active site 63737003608 trimer interface [polypeptide binding]; other site 63737003609 allosteric site; other site 63737003610 active site lid [active] 63737003611 hexamer (dimer of trimers) interface [polypeptide binding]; other site 63737003612 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 63737003613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737003614 active site 63737003615 motif I; other site 63737003616 motif II; other site 63737003617 Predicted transcriptional regulators [Transcription]; Region: COG1695 63737003618 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 63737003619 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 63737003620 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 63737003621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737003622 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 63737003623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737003624 NAD(P) binding site [chemical binding]; other site 63737003625 active site 63737003626 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 63737003627 Helix-turn-helix domain; Region: HTH_25; pfam13413 63737003628 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 63737003629 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 63737003630 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 63737003631 phosphoenolpyruvate synthase; Validated; Region: PRK06241 63737003632 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 63737003633 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 63737003634 Cupin domain; Region: Cupin_2; pfam07883 63737003635 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737003636 CHASE2 domain; Region: CHASE2; pfam05226 63737003637 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 63737003638 cyclase homology domain; Region: CHD; cd07302 63737003639 nucleotidyl binding site; other site 63737003640 metal binding site [ion binding]; metal-binding site 63737003641 dimer interface [polypeptide binding]; other site 63737003642 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737003643 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 63737003644 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 63737003645 hinge; other site 63737003646 active site 63737003647 PhoD-like phosphatase; Region: PhoD; pfam09423 63737003648 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 63737003649 putative active site [active] 63737003650 putative metal binding site [ion binding]; other site 63737003651 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 63737003652 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 63737003653 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 63737003654 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737003655 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737003656 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 63737003657 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 63737003658 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 63737003659 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 63737003660 transmembrane helices; other site 63737003661 Universal stress protein family; Region: Usp; pfam00582 63737003662 Ligand Binding Site [chemical binding]; other site 63737003663 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 63737003664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737003665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003666 dimer interface [polypeptide binding]; other site 63737003667 phosphorylation site [posttranslational modification] 63737003668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003669 ATP binding site [chemical binding]; other site 63737003670 Mg2+ binding site [ion binding]; other site 63737003671 G-X-G motif; other site 63737003672 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 63737003673 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 63737003674 dimerization interface [polypeptide binding]; other site 63737003675 active site 63737003676 metal binding site [ion binding]; metal-binding site 63737003677 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 63737003678 dsRNA binding site [nucleotide binding]; other site 63737003679 LabA_like proteins; Region: LabA_like; cd06167 63737003680 putative metal binding site [ion binding]; other site 63737003681 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737003682 putative active site [active] 63737003683 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 63737003684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737003685 Walker A motif; other site 63737003686 ATP binding site [chemical binding]; other site 63737003687 Walker B motif; other site 63737003688 arginine finger; other site 63737003689 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 63737003690 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 63737003691 metal ion-dependent adhesion site (MIDAS); other site 63737003692 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 63737003693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737003694 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737003695 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 63737003696 DNA binding residues [nucleotide binding] 63737003697 Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner; Region: homeodomain; cl00084 63737003698 DNA binding site [nucleotide binding] 63737003699 specific DNA base contacts [nucleotide binding]; other site 63737003700 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 63737003701 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 63737003702 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 63737003703 This domain is found in peptide chain release factors; Region: PCRF; smart00937 63737003704 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 63737003705 RF-1 domain; Region: RF-1; pfam00472 63737003706 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 63737003707 metal-binding heat shock protein; Provisional; Region: PRK00016 63737003708 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 63737003709 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 63737003710 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 63737003711 glutamine binding [chemical binding]; other site 63737003712 catalytic triad [active] 63737003713 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 63737003714 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 63737003715 Family description; Region: VCBS; pfam13517 63737003716 Family description; Region: VCBS; pfam13517 63737003717 Family description; Region: VCBS; pfam13517 63737003718 Family description; Region: VCBS; pfam13517 63737003719 Family description; Region: VCBS; pfam13517 63737003720 proline aminopeptidase P II; Provisional; Region: PRK10879 63737003721 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 63737003722 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 63737003723 active site 63737003724 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 63737003725 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 63737003726 active site 63737003727 putative substrate binding region [chemical binding]; other site 63737003728 TPR repeat; Region: TPR_11; pfam13414 63737003729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737003730 binding surface 63737003731 TPR motif; other site 63737003732 cell division protein; Validated; Region: ftsH; CHL00176 63737003733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737003734 Walker A motif; other site 63737003735 ATP binding site [chemical binding]; other site 63737003736 Walker B motif; other site 63737003737 arginine finger; other site 63737003738 Peptidase family M41; Region: Peptidase_M41; pfam01434 63737003739 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 63737003740 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 63737003741 HIGH motif; other site 63737003742 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 63737003743 active site 63737003744 KMSKS motif; other site 63737003745 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737003746 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737003747 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737003748 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737003749 active site 63737003750 ATP binding site [chemical binding]; other site 63737003751 substrate binding site [chemical binding]; other site 63737003752 activation loop (A-loop); other site 63737003753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 63737003754 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 63737003755 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 63737003756 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 63737003757 RNase_H superfamily; Region: RNase_H_2; pfam13482 63737003758 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 63737003759 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 63737003760 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737003761 catalytic residue [active] 63737003762 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 63737003763 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 63737003764 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 63737003765 NAD(P) binding site [chemical binding]; other site 63737003766 homodimer interface [polypeptide binding]; other site 63737003767 substrate binding site [chemical binding]; other site 63737003768 active site 63737003769 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 63737003770 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 63737003771 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737003772 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 63737003773 putative ADP-binding pocket [chemical binding]; other site 63737003774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737003775 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 63737003776 putative ADP-binding pocket [chemical binding]; other site 63737003777 O-Antigen ligase; Region: Wzy_C; pfam04932 63737003778 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737003779 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 63737003780 putative ADP-binding pocket [chemical binding]; other site 63737003781 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 63737003782 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 63737003783 active site 63737003784 dimer interface [polypeptide binding]; other site 63737003785 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 63737003786 Ligand Binding Site [chemical binding]; other site 63737003787 Molecular Tunnel; other site 63737003788 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 63737003789 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 63737003790 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 63737003791 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 63737003792 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 63737003793 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737003794 putative NAD(P) binding site [chemical binding]; other site 63737003795 active site 63737003796 putative substrate binding site [chemical binding]; other site 63737003797 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 63737003798 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737003799 putative ADP-binding pocket [chemical binding]; other site 63737003800 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737003801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737003802 S-adenosylmethionine binding site [chemical binding]; other site 63737003803 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 63737003804 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 63737003805 inhibitor-cofactor binding pocket; inhibition site 63737003806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737003807 catalytic residue [active] 63737003808 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737003809 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737003810 Chain length determinant protein; Region: Wzz; cl15801 63737003811 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 63737003812 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737003813 Uncharacterized conserved protein [Function unknown]; Region: COG0432 63737003814 Uncharacterized conserved protein [Function unknown]; Region: COG0327 63737003815 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 63737003816 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 63737003817 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737003818 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737003819 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 63737003820 SprT-like family; Region: SprT-like; pfam10263 63737003821 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737003822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737003823 active site 63737003824 motif I; other site 63737003825 motif II; other site 63737003826 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737003827 Cytochrome P450; Region: p450; pfam00067 63737003828 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 63737003829 iron-sulfur cluster [ion binding]; other site 63737003830 [2Fe-2S] cluster binding site [ion binding]; other site 63737003831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737003832 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737003833 Walker A motif; other site 63737003834 ATP binding site [chemical binding]; other site 63737003835 Walker B motif; other site 63737003836 arginine finger; other site 63737003837 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 63737003838 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 63737003839 Protein of unknown function (DUF2012); Region: DUF2012; pfam09430 63737003840 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 63737003841 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 63737003842 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 63737003843 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 63737003844 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 63737003845 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 63737003846 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 63737003847 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 63737003848 Phage protein D [General function prediction only]; Region: COG3500 63737003849 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 63737003850 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 63737003851 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 63737003852 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 63737003853 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 63737003854 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 63737003855 phage tail protein domain; Region: tail_TIGR02242 63737003856 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 63737003857 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 63737003858 Protein of unknown function, DUF258; Region: DUF258; pfam03193 63737003859 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737003860 structural tetrad; other site 63737003861 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737003862 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737003863 structural tetrad; other site 63737003864 WD domain, G-beta repeat; Region: WD40; pfam00400 63737003865 WD domain, G-beta repeat; Region: WD40; pfam00400 63737003866 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 63737003867 active site clefts [active] 63737003868 zinc binding site [ion binding]; other site 63737003869 dimer interface [polypeptide binding]; other site 63737003870 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 63737003871 putative heme binding site [chemical binding]; other site 63737003872 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 63737003873 Phosphotransferase enzyme family; Region: APH; pfam01636 63737003874 active site 63737003875 substrate binding site [chemical binding]; other site 63737003876 ATP binding site [chemical binding]; other site 63737003877 Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; Region: CHROMO; cd00024 63737003878 histone binding site; other site 63737003879 Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence...; Region: CHROMO; cd00024 63737003880 histone binding site; other site 63737003881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 63737003882 SdiA-regulated; Region: SdiA-regulated; cd09971 63737003883 putative active site [active] 63737003884 Cadherin repeat-like domain; Region: CA_like; cl15786 63737003885 Ca2+ binding site [ion binding]; other site 63737003886 Lamin Tail Domain; Region: LTD; pfam00932 63737003887 Calx-beta domain; Region: Calx-beta; cl02522 63737003888 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 63737003889 generic binding surface II; other site 63737003890 generic binding surface I; other site 63737003891 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 63737003892 putative active site [active] 63737003893 putative catalytic site [active] 63737003894 putative Mg binding site IVb [ion binding]; other site 63737003895 putative DNA binding site [nucleotide binding]; other site 63737003896 putative phosphate binding site [ion binding]; other site 63737003897 putative Mg binding site IVa [ion binding]; other site 63737003898 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 63737003899 Ca2+ binding site [ion binding]; other site 63737003900 VCBS repeat; Region: VCBS_repeat; TIGR01965 63737003901 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 63737003902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737003903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737003904 active site 63737003905 catalytic tetrad [active] 63737003906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737003907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737003908 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 63737003909 mce related protein; Region: MCE; pfam02470 63737003910 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 63737003911 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 63737003912 Walker A/P-loop; other site 63737003913 ATP binding site [chemical binding]; other site 63737003914 Q-loop/lid; other site 63737003915 ABC transporter signature motif; other site 63737003916 Walker B; other site 63737003917 D-loop; other site 63737003918 H-loop/switch region; other site 63737003919 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 63737003920 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 63737003921 tetramer interface [polypeptide binding]; other site 63737003922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737003923 catalytic residue [active] 63737003924 Staphylococcal nuclease homologues; Region: SNc; smart00318 63737003925 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 63737003926 Catalytic site; other site 63737003927 HD domain; Region: HD_4; pfam13328 63737003928 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 63737003929 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737003930 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737003931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003932 dimer interface [polypeptide binding]; other site 63737003933 phosphorylation site [posttranslational modification] 63737003934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003935 ATP binding site [chemical binding]; other site 63737003936 Mg2+ binding site [ion binding]; other site 63737003937 G-X-G motif; other site 63737003938 Cupin domain; Region: Cupin_2; pfam07883 63737003939 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 63737003940 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 63737003941 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 63737003942 CHAT domain; Region: CHAT; pfam12770 63737003943 AAA ATPase domain; Region: AAA_16; pfam13191 63737003944 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737003945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737003946 binding surface 63737003947 TPR motif; other site 63737003948 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737003949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737003950 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737003951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737003952 binding surface 63737003953 TPR motif; other site 63737003954 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737003955 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737003956 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737003957 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 63737003958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003959 dimer interface [polypeptide binding]; other site 63737003960 phosphorylation site [posttranslational modification] 63737003961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003962 ATP binding site [chemical binding]; other site 63737003963 Mg2+ binding site [ion binding]; other site 63737003964 G-X-G motif; other site 63737003965 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 63737003966 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 63737003967 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 63737003968 metal-binding site [ion binding] 63737003969 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737003970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737003971 motif II; other site 63737003972 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 63737003973 metal-binding site [ion binding] 63737003974 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737003975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003976 active site 63737003977 phosphorylation site [posttranslational modification] 63737003978 intermolecular recognition site; other site 63737003979 dimerization interface [polypeptide binding]; other site 63737003980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003981 active site 63737003982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737003983 phosphorylation site [posttranslational modification] 63737003984 intermolecular recognition site; other site 63737003985 dimerization interface [polypeptide binding]; other site 63737003986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737003987 dimer interface [polypeptide binding]; other site 63737003988 phosphorylation site [posttranslational modification] 63737003989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737003990 ATP binding site [chemical binding]; other site 63737003991 Mg2+ binding site [ion binding]; other site 63737003992 G-X-G motif; other site 63737003993 Response regulator receiver domain; Region: Response_reg; pfam00072 63737003994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737003995 active site 63737003996 phosphorylation site [posttranslational modification] 63737003997 intermolecular recognition site; other site 63737003998 dimerization interface [polypeptide binding]; other site 63737003999 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004000 dimer interface [polypeptide binding]; other site 63737004001 phosphorylation site [posttranslational modification] 63737004002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004003 ATP binding site [chemical binding]; other site 63737004004 Mg2+ binding site [ion binding]; other site 63737004005 G-X-G motif; other site 63737004006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737004007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004008 active site 63737004009 phosphorylation site [posttranslational modification] 63737004010 intermolecular recognition site; other site 63737004011 dimerization interface [polypeptide binding]; other site 63737004012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737004013 DNA binding residues [nucleotide binding] 63737004014 dimerization interface [polypeptide binding]; other site 63737004015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 63737004016 conserved hypothetical protein; Region: TIGR03492 63737004017 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 63737004018 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737004019 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 63737004020 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737004021 TIGR03032 family protein; Region: TIGR03032 63737004022 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737004023 VCBS repeat; Region: VCBS_repeat; TIGR01965 63737004024 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737004025 FG-GAP repeat; Region: FG-GAP; cl15299 63737004026 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737004027 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737004028 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737004029 FG-GAP repeat; Region: FG-GAP; cl15299 63737004030 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737004031 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 63737004032 Prostaglandin dehydrogenases; Region: PGDH; cd05288 63737004033 NAD(P) binding site [chemical binding]; other site 63737004034 substrate binding site [chemical binding]; other site 63737004035 dimer interface [polypeptide binding]; other site 63737004036 Winged helix-turn helix; Region: HTH_29; pfam13551 63737004037 Homeodomain-like domain; Region: HTH_23; pfam13384 63737004038 Homeodomain-like domain; Region: HTH_32; pfam13565 63737004039 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737004040 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737004041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 63737004042 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 63737004043 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737004044 putative active site [active] 63737004045 T5orf172 domain; Region: T5orf172; pfam10544 63737004046 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 63737004047 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 63737004048 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737004049 active site 63737004050 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737004051 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 63737004052 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 63737004053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737004054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737004055 ligand binding site [chemical binding]; other site 63737004056 flexible hinge region; other site 63737004057 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737004058 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 63737004059 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 63737004060 HIGH motif; other site 63737004061 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 63737004062 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 63737004063 active site 63737004064 KMSKS motif; other site 63737004065 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 63737004066 tRNA binding surface [nucleotide binding]; other site 63737004067 anticodon binding site; other site 63737004068 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 63737004069 histidine decarboxylase; Provisional; Region: PRK02769 63737004070 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737004071 catalytic residue [active] 63737004072 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737004073 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737004074 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737004075 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737004076 P-loop; other site 63737004077 Magnesium ion binding site [ion binding]; other site 63737004078 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737004079 Magnesium ion binding site [ion binding]; other site 63737004080 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 63737004081 deoxyhypusine synthase; Region: dhys; TIGR00321 63737004082 cyclase homology domain; Region: CHD; cd07302 63737004083 dimer interface [polypeptide binding]; other site 63737004084 nucleotidyl binding site; other site 63737004085 metal binding site [ion binding]; metal-binding site 63737004086 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 63737004087 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 63737004088 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 63737004089 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737004090 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737004091 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 63737004092 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737004093 active site 63737004094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737004095 This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825 63737004096 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 63737004097 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737004098 active site 63737004099 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 63737004100 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 63737004101 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737004102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737004103 active site 63737004104 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737004105 Chain length determinant protein; Region: Wzz; pfam02706 63737004106 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 63737004107 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 63737004108 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737004109 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 63737004110 catalytic motif [active] 63737004111 Zn binding site [ion binding]; other site 63737004112 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737004113 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 63737004114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737004115 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737004116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737004117 DNA binding residues [nucleotide binding] 63737004118 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 63737004119 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737004120 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004121 PAS domain; Region: PAS_9; pfam13426 63737004122 putative active site [active] 63737004123 heme pocket [chemical binding]; other site 63737004124 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737004125 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737004126 metal binding site [ion binding]; metal-binding site 63737004127 active site 63737004128 I-site; other site 63737004129 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737004130 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 63737004131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737004132 active site 63737004133 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 63737004134 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 63737004135 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 63737004136 protein binding site [polypeptide binding]; other site 63737004137 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 63737004138 Catalytic dyad [active] 63737004139 Uncharacterized conserved protein [Function unknown]; Region: COG1434 63737004140 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 63737004141 putative active site [active] 63737004142 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737004143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737004144 Q-loop/lid; other site 63737004145 ABC transporter signature motif; other site 63737004146 Walker B; other site 63737004147 D-loop; other site 63737004148 H-loop/switch region; other site 63737004149 O-methyltransferase; Region: Methyltransf_2; pfam00891 63737004150 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737004151 putative active site [active] 63737004152 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 63737004153 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737004154 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737004155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737004156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004157 active site 63737004158 phosphorylation site [posttranslational modification] 63737004159 intermolecular recognition site; other site 63737004160 dimerization interface [polypeptide binding]; other site 63737004161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737004162 DNA binding residues [nucleotide binding] 63737004163 dimerization interface [polypeptide binding]; other site 63737004164 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 63737004165 Double zinc ribbon; Region: DZR; pfam12773 63737004166 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 63737004167 Protein phosphatase 2C; Region: PP2C; pfam00481 63737004168 active site 63737004169 CHAT domain; Region: CHAT; cl17868 63737004170 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737004171 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737004172 phosphopeptide binding site; other site 63737004173 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737004174 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737004175 phosphopeptide binding site; other site 63737004176 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 63737004177 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 63737004178 Predicted membrane protein [Function unknown]; Region: COG3431 63737004179 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 63737004180 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 63737004181 [4Fe-4S] binding site [ion binding]; other site 63737004182 molybdopterin cofactor binding site; other site 63737004183 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 63737004184 molybdopterin cofactor binding site; other site 63737004185 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 63737004186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737004187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737004188 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 63737004189 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 63737004190 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 63737004191 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 63737004192 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 63737004193 iron-sulfur cluster [ion binding]; other site 63737004194 [2Fe-2S] cluster binding site [ion binding]; other site 63737004195 HEAT repeats; Region: HEAT_2; pfam13646 63737004196 HEAT repeats; Region: HEAT_2; pfam13646 63737004197 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737004198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737004199 non-specific DNA binding site [nucleotide binding]; other site 63737004200 salt bridge; other site 63737004201 sequence-specific DNA binding site [nucleotide binding]; other site 63737004202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 63737004203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737004204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 63737004205 dimerization interface [polypeptide binding]; other site 63737004206 hypothetical protein; Provisional; Region: PRK07394 63737004207 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 63737004208 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 63737004209 Transcriptional regulator [Transcription]; Region: LytR; COG1316 63737004210 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 63737004211 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737004212 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737004213 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 63737004214 serpin-like protein; Provisional; Region: PHA02660 63737004215 reactive center loop; other site 63737004216 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 63737004217 putative catalytic residues [active] 63737004218 putative active site [active] 63737004219 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 63737004220 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 63737004221 substrate binding site [chemical binding]; other site 63737004222 hexamer interface [polypeptide binding]; other site 63737004223 metal binding site [ion binding]; metal-binding site 63737004224 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 63737004225 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 63737004226 Protein of unknown function, DUF608; Region: DUF608; pfam04685 63737004227 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 63737004228 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737004229 active site 63737004230 ATP binding site [chemical binding]; other site 63737004231 substrate binding site [chemical binding]; other site 63737004232 activation loop (A-loop); other site 63737004233 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737004234 structural tetrad; other site 63737004235 PQQ-like domain; Region: PQQ_2; pfam13360 63737004236 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737004237 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737004238 active site 63737004239 ATP binding site [chemical binding]; other site 63737004240 substrate binding site [chemical binding]; other site 63737004241 activation loop (A-loop); other site 63737004242 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 63737004243 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 63737004244 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 63737004245 putative active site [active] 63737004246 catalytic site [active] 63737004247 NifU-like domain; Region: NifU; pfam01106 63737004248 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004249 GAF domain; Region: GAF_3; pfam13492 63737004250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004251 dimer interface [polypeptide binding]; other site 63737004252 phosphorylation site [posttranslational modification] 63737004253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004254 ATP binding site [chemical binding]; other site 63737004255 Mg2+ binding site [ion binding]; other site 63737004256 G-X-G motif; other site 63737004257 GTP-binding protein LepA; Provisional; Region: PRK05433 63737004258 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 63737004259 G1 box; other site 63737004260 putative GEF interaction site [polypeptide binding]; other site 63737004261 GTP/Mg2+ binding site [chemical binding]; other site 63737004262 Switch I region; other site 63737004263 G2 box; other site 63737004264 G3 box; other site 63737004265 Switch II region; other site 63737004266 G4 box; other site 63737004267 G5 box; other site 63737004268 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 63737004269 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 63737004270 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 63737004271 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737004272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004273 putative active site [active] 63737004274 heme pocket [chemical binding]; other site 63737004275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004276 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737004277 putative active site [active] 63737004278 heme pocket [chemical binding]; other site 63737004279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004280 putative active site [active] 63737004281 heme pocket [chemical binding]; other site 63737004282 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004283 PAS fold; Region: PAS_3; pfam08447 63737004284 putative active site [active] 63737004285 heme pocket [chemical binding]; other site 63737004286 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004287 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004288 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737004289 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737004290 metal binding site [ion binding]; metal-binding site 63737004291 active site 63737004292 I-site; other site 63737004293 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737004294 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737004295 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737004296 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737004297 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737004298 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737004299 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737004300 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737004301 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737004302 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737004303 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 63737004304 putative hexamer interface [polypeptide binding]; other site 63737004305 putative hexagonal pore; other site 63737004306 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 63737004307 Hexamer interface [polypeptide binding]; other site 63737004308 Hexagonal pore residue; other site 63737004309 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 63737004310 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 63737004311 putative ADP-binding pocket [chemical binding]; other site 63737004312 Sulfatase; Region: Sulfatase; cl17466 63737004313 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 63737004314 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 63737004315 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 63737004316 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 63737004317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737004318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737004319 putative substrate translocation pore; other site 63737004320 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 63737004321 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 63737004322 N- and C-terminal domain interface [polypeptide binding]; other site 63737004323 active site 63737004324 MgATP binding site [chemical binding]; other site 63737004325 catalytic site [active] 63737004326 metal binding site [ion binding]; metal-binding site 63737004327 glycerol binding site [chemical binding]; other site 63737004328 homotetramer interface [polypeptide binding]; other site 63737004329 homodimer interface [polypeptide binding]; other site 63737004330 FBP binding site [chemical binding]; other site 63737004331 protein IIAGlc interface [polypeptide binding]; other site 63737004332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004333 PAS domain; Region: PAS_9; pfam13426 63737004334 putative active site [active] 63737004335 heme pocket [chemical binding]; other site 63737004336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737004337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 63737004338 ligand binding site [chemical binding]; other site 63737004339 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 63737004340 putative switch regulator; other site 63737004341 non-specific DNA interactions [nucleotide binding]; other site 63737004342 DNA binding site [nucleotide binding] 63737004343 sequence specific DNA binding site [nucleotide binding]; other site 63737004344 putative cAMP binding site [chemical binding]; other site 63737004345 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737004346 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 63737004347 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 63737004348 putative active site [active] 63737004349 putative dimer interface [polypeptide binding]; other site 63737004350 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 63737004351 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 63737004352 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 63737004353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737004354 S-adenosylmethionine binding site [chemical binding]; other site 63737004355 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 63737004356 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 63737004357 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 63737004358 Walker A/P-loop; other site 63737004359 ATP binding site [chemical binding]; other site 63737004360 Q-loop/lid; other site 63737004361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737004362 ABC transporter signature motif; other site 63737004363 Walker B; other site 63737004364 D-loop; other site 63737004365 H-loop/switch region; other site 63737004366 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737004367 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737004368 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737004369 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737004370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737004371 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737004372 Bacterial SH3 domain; Region: SH3_3; cl17532 63737004373 Ycf46; Provisional; Region: ycf46; CHL00195 63737004374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737004375 Walker A motif; other site 63737004376 ATP binding site [chemical binding]; other site 63737004377 Walker B motif; other site 63737004378 arginine finger; other site 63737004379 HEAT repeats; Region: HEAT_2; pfam13646 63737004380 HEAT repeats; Region: HEAT_2; pfam13646 63737004381 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 63737004382 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 63737004383 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 63737004384 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 63737004385 G-X-X-G motif; other site 63737004386 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 63737004387 RxxxH motif; other site 63737004388 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 63737004389 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 63737004390 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 63737004391 Bacterial PH domain; Region: DUF304; pfam03703 63737004392 ribonuclease P; Reviewed; Region: rnpA; PRK03031 63737004393 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 63737004394 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 63737004395 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 63737004396 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 63737004397 ligand binding site [chemical binding]; other site 63737004398 homodimer interface [polypeptide binding]; other site 63737004399 NAD(P) binding site [chemical binding]; other site 63737004400 trimer interface B [polypeptide binding]; other site 63737004401 trimer interface A [polypeptide binding]; other site 63737004402 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 63737004403 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 63737004404 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 63737004405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 63737004406 active site 63737004407 PemK-like protein; Region: PemK; pfam02452 63737004408 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004409 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004410 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004411 GAF domain; Region: GAF; pfam01590 63737004412 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004413 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004414 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004415 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737004418 dimer interface [polypeptide binding]; other site 63737004419 phosphorylation site [posttranslational modification] 63737004420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004421 ATP binding site [chemical binding]; other site 63737004422 Mg2+ binding site [ion binding]; other site 63737004423 G-X-G motif; other site 63737004424 PetN; Region: PetN; pfam03742 63737004425 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004427 dimer interface [polypeptide binding]; other site 63737004428 phosphorylation site [posttranslational modification] 63737004429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004430 ATP binding site [chemical binding]; other site 63737004431 Mg2+ binding site [ion binding]; other site 63737004432 G-X-G motif; other site 63737004433 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737004434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004435 active site 63737004436 phosphorylation site [posttranslational modification] 63737004437 intermolecular recognition site; other site 63737004438 dimerization interface [polypeptide binding]; other site 63737004439 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004441 active site 63737004442 phosphorylation site [posttranslational modification] 63737004443 intermolecular recognition site; other site 63737004444 dimerization interface [polypeptide binding]; other site 63737004445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004447 ATP binding site [chemical binding]; other site 63737004448 Mg2+ binding site [ion binding]; other site 63737004449 G-X-G motif; other site 63737004450 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 63737004451 active site 63737004452 catalytic site [active] 63737004453 substrate binding site [chemical binding]; other site 63737004454 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 63737004455 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 63737004456 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 63737004457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737004458 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737004459 S-adenosylmethionine binding site [chemical binding]; other site 63737004460 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 63737004461 hypothetical protein; Provisional; Region: PRK02509 63737004462 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 63737004463 Uncharacterized conserved protein [Function unknown]; Region: COG1615 63737004464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737004465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737004466 active site 63737004467 ATP binding site [chemical binding]; other site 63737004468 substrate binding site [chemical binding]; other site 63737004469 activation loop (A-loop); other site 63737004470 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737004471 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737004472 structural tetrad; other site 63737004473 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 63737004474 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 63737004475 Cl- selectivity filter; other site 63737004476 Cl- binding residues [ion binding]; other site 63737004477 pore gating glutamate residue; other site 63737004478 dimer interface [polypeptide binding]; other site 63737004479 H+/Cl- coupling transport residue; other site 63737004480 FOG: CBS domain [General function prediction only]; Region: COG0517 63737004481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 63737004482 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 63737004483 Ligand Binding Site [chemical binding]; other site 63737004484 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737004485 Ligand Binding Site [chemical binding]; other site 63737004486 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 63737004487 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 63737004488 Phosphoesterase family; Region: Phosphoesterase; pfam04185 63737004489 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 63737004490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737004491 motif II; other site 63737004492 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 63737004493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737004494 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737004495 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 63737004496 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 63737004497 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 63737004498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 63737004499 ABC-ATPase subunit interface; other site 63737004500 dimer interface [polypeptide binding]; other site 63737004501 putative PBP binding regions; other site 63737004502 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 63737004503 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 63737004504 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 63737004505 putative dimer interface [polypeptide binding]; other site 63737004506 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737004507 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737004508 catalytic loop [active] 63737004509 iron binding site [ion binding]; other site 63737004510 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 63737004511 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 63737004512 active site 63737004513 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737004514 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 63737004515 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737004516 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737004517 CHASE2 domain; Region: CHASE2; pfam05226 63737004518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 63737004519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737004520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004521 active site 63737004522 phosphorylation site [posttranslational modification] 63737004523 intermolecular recognition site; other site 63737004524 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 63737004525 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 63737004526 CHAT domain; Region: CHAT; cl17868 63737004527 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737004528 CHASE2 domain; Region: CHASE2; pfam05226 63737004529 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737004530 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 63737004531 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 63737004532 Competence protein; Region: Competence; pfam03772 63737004533 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 63737004534 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 63737004535 dimer interface [polypeptide binding]; other site 63737004536 motif 1; other site 63737004537 active site 63737004538 motif 2; other site 63737004539 motif 3; other site 63737004540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 63737004541 Transposase and inactivated derivatives, IS1 family [DNA replication, recombination, and repair]; Region: InsB; COG1662 63737004542 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 63737004543 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737004544 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 63737004545 diiron binding motif [ion binding]; other site 63737004546 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 63737004547 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 63737004548 molybdopterin cofactor binding site; other site 63737004549 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 63737004550 molybdopterin cofactor binding site; other site 63737004551 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 63737004552 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737004553 active site 63737004554 catalytic residues [active] 63737004555 DNA binding site [nucleotide binding] 63737004556 Int/Topo IB signature motif; other site 63737004557 Domain of unknown function DUF87; Region: DUF87; pfam01935 63737004558 KGK domain; Region: KGK; pfam08872 63737004559 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 63737004560 active site 63737004561 metal binding site [ion binding]; metal-binding site 63737004562 interdomain interaction site; other site 63737004563 Virulence-associated protein E; Region: VirE; pfam05272 63737004564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004565 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004566 active site 63737004567 phosphorylation site [posttranslational modification] 63737004568 intermolecular recognition site; other site 63737004569 dimerization interface [polypeptide binding]; other site 63737004570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737004571 dimerization interface [polypeptide binding]; other site 63737004572 putative DNA binding site [nucleotide binding]; other site 63737004573 putative Zn2+ binding site [ion binding]; other site 63737004574 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 63737004575 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737004576 anti sigma factor interaction site; other site 63737004577 regulatory phosphorylation site [posttranslational modification]; other site 63737004578 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004580 active site 63737004581 phosphorylation site [posttranslational modification] 63737004582 intermolecular recognition site; other site 63737004583 dimerization interface [polypeptide binding]; other site 63737004584 Monopolin complex subunit LRS4; Region: LRS4; pfam10422 63737004585 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 63737004586 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 63737004587 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 63737004588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 63737004589 ATP binding site [chemical binding]; other site 63737004590 Mg2+ binding site [ion binding]; other site 63737004591 G-X-G motif; other site 63737004592 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004593 GAF domain; Region: GAF; pfam01590 63737004594 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 63737004595 PAS domain S-box; Region: sensory_box; TIGR00229 63737004596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004597 putative active site [active] 63737004598 heme pocket [chemical binding]; other site 63737004599 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004600 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004601 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004602 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004603 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004605 dimer interface [polypeptide binding]; other site 63737004606 phosphorylation site [posttranslational modification] 63737004607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004608 ATP binding site [chemical binding]; other site 63737004609 Mg2+ binding site [ion binding]; other site 63737004610 G-X-G motif; other site 63737004611 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737004612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004613 active site 63737004614 phosphorylation site [posttranslational modification] 63737004615 intermolecular recognition site; other site 63737004616 dimerization interface [polypeptide binding]; other site 63737004617 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004619 active site 63737004620 phosphorylation site [posttranslational modification] 63737004621 intermolecular recognition site; other site 63737004622 dimerization interface [polypeptide binding]; other site 63737004623 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 63737004624 putative binding surface; other site 63737004625 active site 63737004626 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 63737004627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737004628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004629 active site 63737004630 phosphorylation site [posttranslational modification] 63737004631 intermolecular recognition site; other site 63737004632 dimerization interface [polypeptide binding]; other site 63737004633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737004634 DNA binding site [nucleotide binding] 63737004635 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 63737004636 DNA binding residues [nucleotide binding] 63737004637 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 63737004638 dimer interface [polypeptide binding]; other site 63737004639 metal binding site [ion binding]; metal-binding site 63737004640 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737004641 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 63737004642 [2Fe-2S] cluster binding site [ion binding]; other site 63737004643 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 63737004644 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737004645 Soluble P-type ATPase [General function prediction only]; Region: COG4087 63737004646 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 63737004647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737004648 ATP binding site [chemical binding]; other site 63737004649 putative Mg++ binding site [ion binding]; other site 63737004650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737004651 nucleotide binding region [chemical binding]; other site 63737004652 ATP-binding site [chemical binding]; other site 63737004653 FlxA-like protein; Region: FlxA; pfam14282 63737004654 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 63737004655 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 63737004656 pyrroline-5-carboxylate reductase; Region: PLN02688 63737004657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 63737004658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 63737004659 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 63737004660 catalytic residue [active] 63737004661 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 63737004662 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 63737004663 GTP-binding protein Der; Reviewed; Region: PRK00093 63737004664 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 63737004665 G1 box; other site 63737004666 GTP/Mg2+ binding site [chemical binding]; other site 63737004667 Switch I region; other site 63737004668 G2 box; other site 63737004669 Switch II region; other site 63737004670 G3 box; other site 63737004671 G4 box; other site 63737004672 G5 box; other site 63737004673 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 63737004674 G1 box; other site 63737004675 GTP/Mg2+ binding site [chemical binding]; other site 63737004676 Switch I region; other site 63737004677 G2 box; other site 63737004678 G3 box; other site 63737004679 Switch II region; other site 63737004680 G4 box; other site 63737004681 G5 box; other site 63737004682 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 63737004683 Peptidase family M50; Region: Peptidase_M50; pfam02163 63737004684 active site 63737004685 putative substrate binding region [chemical binding]; other site 63737004686 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 63737004687 FOG: CBS domain [General function prediction only]; Region: COG0517 63737004688 photosystem I reaction center subunit X-like protein; Reviewed; Region: PRK13216 63737004689 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 63737004690 active site 63737004691 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 63737004692 homodecamer interface [polypeptide binding]; other site 63737004693 GTP cyclohydrolase I; Provisional; Region: PLN03044 63737004694 active site 63737004695 putative catalytic site residues [active] 63737004696 zinc binding site [ion binding]; other site 63737004697 GTP-CH-I/GFRP interaction surface; other site 63737004698 short chain dehydrogenase; Provisional; Region: PRK07454 63737004699 classical (c) SDRs; Region: SDR_c; cd05233 63737004700 NAD(P) binding site [chemical binding]; other site 63737004701 active site 63737004702 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 63737004703 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 63737004704 acyl-ACP reductase; Provisional; Region: PRK14982 63737004705 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 63737004706 NAD(P) binding pocket [chemical binding]; other site 63737004707 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 63737004708 dinuclear metal binding motif [ion binding]; other site 63737004709 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 63737004710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737004711 dimer interface [polypeptide binding]; other site 63737004712 conserved gate region; other site 63737004713 putative PBP binding loops; other site 63737004714 ABC-ATPase subunit interface; other site 63737004715 AMP deaminase; Provisional; Region: PTZ00310 63737004716 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737004717 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 63737004718 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737004719 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 63737004720 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737004721 FeS/SAM binding site; other site 63737004722 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 63737004723 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 63737004724 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 63737004725 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 63737004726 RNA binding surface [nucleotide binding]; other site 63737004727 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 63737004728 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 63737004729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737004730 putative substrate translocation pore; other site 63737004731 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 63737004732 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 63737004733 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737004734 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 63737004735 putative NAD(P) binding site [chemical binding]; other site 63737004736 catalytic Zn binding site [ion binding]; other site 63737004737 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 63737004738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737004739 Coenzyme A binding pocket [chemical binding]; other site 63737004740 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 63737004741 tellurite resistance protein terB; Region: terB; cd07176 63737004742 putative metal binding site [ion binding]; other site 63737004743 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 63737004744 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737004745 PYR/PP interface [polypeptide binding]; other site 63737004746 dimer interface [polypeptide binding]; other site 63737004747 TPP binding site [chemical binding]; other site 63737004748 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737004749 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 63737004750 TPP-binding site [chemical binding]; other site 63737004751 dimer interface [polypeptide binding]; other site 63737004752 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 63737004753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737004754 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737004755 putative substrate translocation pore; other site 63737004756 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 63737004757 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 63737004758 C-terminal domain interface [polypeptide binding]; other site 63737004759 active site 63737004760 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 63737004761 active site 63737004762 N-terminal domain interface [polypeptide binding]; other site 63737004763 Predicted flavoprotein [General function prediction only]; Region: COG0431 63737004764 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737004765 cell division protein; Validated; Region: ftsH; CHL00176 63737004766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737004767 Walker A motif; other site 63737004768 ATP binding site [chemical binding]; other site 63737004769 Walker B motif; other site 63737004770 arginine finger; other site 63737004771 Peptidase family M41; Region: Peptidase_M41; pfam01434 63737004772 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737004773 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 63737004774 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 63737004775 active site 63737004776 non-prolyl cis peptide bond; other site 63737004777 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 63737004778 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 63737004779 active site 63737004780 non-prolyl cis peptide bond; other site 63737004781 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737004782 Predicted esterase [General function prediction only]; Region: COG0400 63737004783 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737004784 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737004785 active site 63737004786 catalytic tetrad [active] 63737004787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737004788 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737004789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737004790 Walker A/P-loop; other site 63737004791 ATP binding site [chemical binding]; other site 63737004792 Q-loop/lid; other site 63737004793 ABC transporter signature motif; other site 63737004794 Walker B; other site 63737004795 D-loop; other site 63737004796 H-loop/switch region; other site 63737004797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004798 GAF domain; Region: GAF; pfam01590 63737004799 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737004800 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 63737004801 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 63737004802 active site 63737004803 interdomain interaction site; other site 63737004804 putative metal-binding site [ion binding]; other site 63737004805 nucleotide binding site [chemical binding]; other site 63737004806 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 63737004807 domain I; other site 63737004808 phosphate binding site [ion binding]; other site 63737004809 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 63737004810 domain II; other site 63737004811 domain III; other site 63737004812 nucleotide binding site [chemical binding]; other site 63737004813 DNA binding groove [nucleotide binding] 63737004814 catalytic site [active] 63737004815 domain IV; other site 63737004816 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 63737004817 Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910 63737004818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004819 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004820 active site 63737004821 phosphorylation site [posttranslational modification] 63737004822 intermolecular recognition site; other site 63737004823 dimerization interface [polypeptide binding]; other site 63737004824 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004826 active site 63737004827 phosphorylation site [posttranslational modification] 63737004828 intermolecular recognition site; other site 63737004829 dimerization interface [polypeptide binding]; other site 63737004830 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004831 GAF domain; Region: GAF; pfam01590 63737004832 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 63737004833 Phytochrome region; Region: PHY; pfam00360 63737004834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004835 dimer interface [polypeptide binding]; other site 63737004836 phosphorylation site [posttranslational modification] 63737004837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004838 ATP binding site [chemical binding]; other site 63737004839 Mg2+ binding site [ion binding]; other site 63737004840 G-X-G motif; other site 63737004841 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004842 GAF domain; Region: GAF_2; pfam13185 63737004843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004845 dimer interface [polypeptide binding]; other site 63737004846 phosphorylation site [posttranslational modification] 63737004847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004848 ATP binding site [chemical binding]; other site 63737004849 Mg2+ binding site [ion binding]; other site 63737004850 G-X-G motif; other site 63737004851 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737004852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004853 active site 63737004854 phosphorylation site [posttranslational modification] 63737004855 intermolecular recognition site; other site 63737004856 dimerization interface [polypeptide binding]; other site 63737004857 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 63737004858 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737004859 active site 63737004860 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 63737004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737004862 putative substrate translocation pore; other site 63737004863 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 63737004864 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 63737004865 Peptidase family M50; Region: Peptidase_M50; pfam02163 63737004866 active site 63737004867 putative substrate binding region [chemical binding]; other site 63737004868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737004869 Protein kinase domain; Region: Pkinase; pfam00069 63737004870 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737004871 active site 63737004872 ATP binding site [chemical binding]; other site 63737004873 substrate binding site [chemical binding]; other site 63737004874 activation loop (A-loop); other site 63737004875 AAA ATPase domain; Region: AAA_16; pfam13191 63737004876 Predicted ATPase [General function prediction only]; Region: COG3899 63737004877 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737004878 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737004879 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004880 PAS fold; Region: PAS_3; pfam08447 63737004881 putative active site [active] 63737004882 heme pocket [chemical binding]; other site 63737004883 PAS domain S-box; Region: sensory_box; TIGR00229 63737004884 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737004885 putative active site [active] 63737004886 heme pocket [chemical binding]; other site 63737004887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004889 ATP binding site [chemical binding]; other site 63737004890 Mg2+ binding site [ion binding]; other site 63737004891 G-X-G motif; other site 63737004892 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 63737004893 Protein export membrane protein; Region: SecD_SecF; cl14618 63737004894 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 63737004895 Protein export membrane protein; Region: SecD_SecF; cl14618 63737004896 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737004897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737004898 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737004899 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737004900 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 63737004901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737004902 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737004903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737004904 DNA binding residues [nucleotide binding] 63737004905 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 63737004906 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 63737004907 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 63737004908 protein binding site [polypeptide binding]; other site 63737004909 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 63737004910 Catalytic dyad [active] 63737004911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 63737004912 Histidine kinase; Region: HisKA_3; pfam07730 63737004913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004914 ATP binding site [chemical binding]; other site 63737004915 Mg2+ binding site [ion binding]; other site 63737004916 G-X-G motif; other site 63737004917 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737004918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004919 active site 63737004920 phosphorylation site [posttranslational modification] 63737004921 intermolecular recognition site; other site 63737004922 dimerization interface [polypeptide binding]; other site 63737004923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737004924 DNA binding residues [nucleotide binding] 63737004925 dimerization interface [polypeptide binding]; other site 63737004926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737004927 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004928 dimer interface [polypeptide binding]; other site 63737004929 phosphorylation site [posttranslational modification] 63737004930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004931 ATP binding site [chemical binding]; other site 63737004932 Mg2+ binding site [ion binding]; other site 63737004933 G-X-G motif; other site 63737004934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737004935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004936 active site 63737004937 phosphorylation site [posttranslational modification] 63737004938 intermolecular recognition site; other site 63737004939 dimerization interface [polypeptide binding]; other site 63737004940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737004941 DNA binding site [nucleotide binding] 63737004942 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 63737004943 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737004944 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 63737004945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737004946 substrate binding pocket [chemical binding]; other site 63737004947 membrane-bound complex binding site; other site 63737004948 hinge residues; other site 63737004949 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737004950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737004951 active site 63737004952 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737004953 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737004954 active site 63737004955 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 63737004956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737004957 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737004958 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 63737004959 Subunit I/III interface [polypeptide binding]; other site 63737004960 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 63737004961 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 63737004962 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 63737004963 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 63737004964 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 63737004965 Predicted membrane protein [Function unknown]; Region: COG4244 63737004966 Predicted membrane protein [Function unknown]; Region: COG4244 63737004967 glucose-1-dehydrogenase; Provisional; Region: PRK08936 63737004968 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 63737004969 NAD binding site [chemical binding]; other site 63737004970 homodimer interface [polypeptide binding]; other site 63737004971 active site 63737004972 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 63737004973 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 63737004974 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 63737004975 Cation efflux family; Region: Cation_efflux; pfam01545 63737004976 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 63737004977 Domain interface; other site 63737004978 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 63737004979 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 63737004980 Cupin domain; Region: Cupin_2; cl17218 63737004981 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737004982 Cache domain; Region: Cache_1; pfam02743 63737004983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 63737004984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737004985 dimerization interface [polypeptide binding]; other site 63737004986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737004987 dimer interface [polypeptide binding]; other site 63737004988 phosphorylation site [posttranslational modification] 63737004989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737004990 ATP binding site [chemical binding]; other site 63737004991 Mg2+ binding site [ion binding]; other site 63737004992 G-X-G motif; other site 63737004993 Response regulator receiver domain; Region: Response_reg; pfam00072 63737004994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737004995 active site 63737004996 phosphorylation site [posttranslational modification] 63737004997 intermolecular recognition site; other site 63737004998 dimerization interface [polypeptide binding]; other site 63737004999 Response regulator receiver domain; Region: Response_reg; pfam00072 63737005000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005001 active site 63737005002 phosphorylation site [posttranslational modification] 63737005003 intermolecular recognition site; other site 63737005004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737005005 dimerization interface [polypeptide binding]; other site 63737005006 Histidine kinase; Region: HisKA_3; pfam07730 63737005007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737005008 ATP binding site [chemical binding]; other site 63737005009 Mg2+ binding site [ion binding]; other site 63737005010 G-X-G motif; other site 63737005011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737005012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005013 active site 63737005014 phosphorylation site [posttranslational modification] 63737005015 intermolecular recognition site; other site 63737005016 dimerization interface [polypeptide binding]; other site 63737005017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737005018 DNA binding residues [nucleotide binding] 63737005019 dimerization interface [polypeptide binding]; other site 63737005020 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 63737005021 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 63737005022 ligand binding site [chemical binding]; other site 63737005023 flexible hinge region; other site 63737005024 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 63737005025 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737005026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737005027 Walker A/P-loop; other site 63737005028 ATP binding site [chemical binding]; other site 63737005029 Q-loop/lid; other site 63737005030 ABC transporter signature motif; other site 63737005031 Walker B; other site 63737005032 D-loop; other site 63737005033 H-loop/switch region; other site 63737005034 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 63737005035 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 63737005036 putative active site [active] 63737005037 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737005038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737005039 Walker A/P-loop; other site 63737005040 ATP binding site [chemical binding]; other site 63737005041 Q-loop/lid; other site 63737005042 ABC transporter signature motif; other site 63737005043 Walker B; other site 63737005044 D-loop; other site 63737005045 H-loop/switch region; other site 63737005046 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 63737005047 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737005048 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737005049 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737005050 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 63737005051 ligand binding site [chemical binding]; other site 63737005052 flexible hinge region; other site 63737005053 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737005054 ligand binding site [chemical binding]; other site 63737005055 flexible hinge region; other site 63737005056 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737005057 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 63737005058 HAMP domain; Region: HAMP; pfam00672 63737005059 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 63737005060 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737005061 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 63737005062 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 63737005063 Cl- selectivity filter; other site 63737005064 Cl- binding residues [ion binding]; other site 63737005065 pore gating glutamate residue; other site 63737005066 dimer interface [polypeptide binding]; other site 63737005067 H+/Cl- coupling transport residue; other site 63737005068 FOG: CBS domain [General function prediction only]; Region: COG0517 63737005069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 63737005070 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 63737005071 Ligand Binding Site [chemical binding]; other site 63737005072 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737005073 Ligand Binding Site [chemical binding]; other site 63737005074 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 63737005075 active site clefts [active] 63737005076 zinc binding site [ion binding]; other site 63737005077 dimer interface [polypeptide binding]; other site 63737005078 cyanophycin synthetase; Provisional; Region: PRK14016 63737005079 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 63737005080 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 63737005081 proposed catalytic triad [active] 63737005082 active site nucleophile [active] 63737005083 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 63737005084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005085 binding surface 63737005086 TPR motif; other site 63737005087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005089 binding surface 63737005090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005091 TPR motif; other site 63737005092 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005093 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005094 binding surface 63737005095 TPR motif; other site 63737005096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005097 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737005099 active site 63737005100 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 63737005101 Fe-S cluster binding site [ion binding]; other site 63737005102 active site 63737005103 Bacterial SH3 domain; Region: SH3_3; pfam08239 63737005104 Bacterial SH3 domain; Region: SH3_3; pfam08239 63737005105 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737005106 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 63737005107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005108 TPR repeat; Region: TPR_11; pfam13414 63737005109 binding surface 63737005110 TPR motif; other site 63737005111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005112 binding surface 63737005113 TPR motif; other site 63737005114 TPR repeat; Region: TPR_11; pfam13414 63737005115 TPR repeat; Region: TPR_11; pfam13414 63737005116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005117 binding surface 63737005118 TPR motif; other site 63737005119 TPR repeat; Region: TPR_11; pfam13414 63737005120 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 63737005121 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 63737005122 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 63737005123 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 63737005124 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 63737005125 substrate binding pocket [chemical binding]; other site 63737005126 chain length determination region; other site 63737005127 substrate-Mg2+ binding site; other site 63737005128 catalytic residues [active] 63737005129 aspartate-rich region 1; other site 63737005130 active site lid residues [active] 63737005131 aspartate-rich region 2; other site 63737005132 rod shape-determining protein MreD; Region: MreD; cl01087 63737005133 rod shape-determining protein MreC; Provisional; Region: PRK13922 63737005134 rod shape-determining protein MreC; Region: MreC; pfam04085 63737005135 rod shape-determining protein MreB; Provisional; Region: PRK13927 63737005136 MreB and similar proteins; Region: MreB_like; cd10225 63737005137 nucleotide binding site [chemical binding]; other site 63737005138 Mg binding site [ion binding]; other site 63737005139 putative protofilament interaction site [polypeptide binding]; other site 63737005140 RodZ interaction site [polypeptide binding]; other site 63737005141 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 63737005142 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 63737005143 dimer interface [polypeptide binding]; other site 63737005144 ssDNA binding site [nucleotide binding]; other site 63737005145 tetramer (dimer of dimers) interface [polypeptide binding]; other site 63737005146 Uncharacterized conserved protein [Function unknown]; Region: COG2968 63737005147 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 63737005148 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 63737005149 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 63737005150 AMIN domain; Region: AMIN; pfam11741 63737005151 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 63737005152 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 63737005153 active site 63737005154 metal binding site [ion binding]; metal-binding site 63737005155 AMIN domain; Region: AMIN; pfam11741 63737005156 AMIN domain; Region: AMIN; pfam11741 63737005157 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 63737005158 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 63737005159 active site 63737005160 metal binding site [ion binding]; metal-binding site 63737005161 glutamate racemase; Provisional; Region: PRK00865 63737005162 methionine sulfoxide reductase B; Provisional; Region: PRK00222 63737005163 SelR domain; Region: SelR; pfam01641 63737005164 TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223 63737005165 active site 63737005166 metal binding site [ion binding]; metal-binding site 63737005167 interdomain interaction site; other site 63737005168 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 63737005169 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 63737005170 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 63737005171 catalytic residue [active] 63737005172 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 63737005173 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 63737005174 Ligand Binding Site [chemical binding]; other site 63737005175 Molecular Tunnel; other site 63737005176 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 63737005177 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 63737005178 active site 63737005179 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 63737005180 Ligand Binding Site [chemical binding]; other site 63737005181 Molecular Tunnel; other site 63737005182 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 63737005183 Amidase; Region: Amidase; pfam01425 63737005184 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 63737005185 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 63737005186 active site 63737005187 dimer interface [polypeptide binding]; other site 63737005188 non-prolyl cis peptide bond; other site 63737005189 insertion regions; other site 63737005190 Putative phosphatase (DUF442); Region: DUF442; cl17385 63737005191 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 63737005192 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 63737005193 Ligand binding site; other site 63737005194 metal-binding site 63737005195 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737005196 Tic55 is a 55kDa LLS1-related non-heme iron oxygenase associated with protein transport through the plant inner chloroplast membrane. This domain represents the N-terminal Rieske domain of the Tic55 oxygenase alpha subunit. Tic55 is closely related to...; Region: Rieske_RO_Alpha_Tic55; cd04338 63737005197 Pheophorbide a oxygenase; Region: PaO; pfam08417 63737005198 dephospho-CoA kinase; Region: TIGR00152 63737005199 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 63737005200 CoA-binding site [chemical binding]; other site 63737005201 ATP-binding [chemical binding]; other site 63737005202 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 63737005203 active site 63737005204 SAM binding site [chemical binding]; other site 63737005205 homodimer interface [polypeptide binding]; other site 63737005206 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 63737005207 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 63737005208 active site 63737005209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005210 TPR repeat; Region: TPR_11; pfam13414 63737005211 binding surface 63737005212 TPR motif; other site 63737005213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005214 binding surface 63737005215 TPR repeat; Region: TPR_11; pfam13414 63737005216 TPR motif; other site 63737005217 TPR repeat; Region: TPR_11; pfam13414 63737005218 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737005219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005220 binding surface 63737005221 TPR motif; other site 63737005222 TPR repeat; Region: TPR_11; pfam13414 63737005223 TPR repeat; Region: TPR_11; pfam13414 63737005224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005225 binding surface 63737005226 TPR motif; other site 63737005227 TPR repeat; Region: TPR_11; pfam13414 63737005228 TPR repeat; Region: TPR_11; pfam13414 63737005229 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737005230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005231 putative active site [active] 63737005232 heme pocket [chemical binding]; other site 63737005233 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737005234 dimer interface [polypeptide binding]; other site 63737005235 phosphorylation site [posttranslational modification] 63737005236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737005237 ATP binding site [chemical binding]; other site 63737005238 Mg2+ binding site [ion binding]; other site 63737005239 G-X-G motif; other site 63737005240 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737005241 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005242 active site 63737005243 phosphorylation site [posttranslational modification] 63737005244 intermolecular recognition site; other site 63737005245 dimerization interface [polypeptide binding]; other site 63737005246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005247 binding surface 63737005248 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737005249 TPR motif; other site 63737005250 TPR repeat; Region: TPR_11; pfam13414 63737005251 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 63737005252 UbiA prenyltransferase family; Region: UbiA; pfam01040 63737005253 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737005254 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737005255 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 63737005256 active site 63737005257 SAM binding site [chemical binding]; other site 63737005258 homodimer interface [polypeptide binding]; other site 63737005259 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 63737005260 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 63737005261 putative active site [active] 63737005262 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 63737005263 putative active site [active] 63737005264 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 63737005265 sucrose synthase; Region: sucr_synth; TIGR02470 63737005266 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 63737005267 putative ADP-binding pocket [chemical binding]; other site 63737005268 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737005269 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 63737005270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 63737005271 nucleotide binding site [chemical binding]; other site 63737005272 2TM domain; Region: 2TM; pfam13239 63737005273 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005274 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005275 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005276 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005277 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005278 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005279 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005280 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005281 cytochrome c6; Provisional; Region: PRK13697 63737005282 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 63737005283 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737005284 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737005285 active site 63737005286 catalytic tetrad [active] 63737005287 hydrolase, alpha/beta fold family protein; Region: PLN02824 63737005288 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737005289 BON domain; Region: BON; cl02771 63737005290 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 63737005291 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 63737005292 putative valine binding site [chemical binding]; other site 63737005293 dimer interface [polypeptide binding]; other site 63737005294 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 63737005295 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 63737005296 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 63737005297 ligand binding site [chemical binding]; other site 63737005298 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 63737005299 Rab subfamily motif 1 (RabSF1); other site 63737005300 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 63737005301 G1 box; other site 63737005302 GTP/Mg2+ binding site [chemical binding]; other site 63737005303 Rab subfamily motif 2 (RabSF2); other site 63737005304 Switch I region; other site 63737005305 G2 box; other site 63737005306 effector interaction site; other site 63737005307 GDI interaction site; other site 63737005308 Rab family motif 1 (RabF1); other site 63737005309 GEF interaction site [polypeptide binding]; other site 63737005310 Rab family motif 2 (RabF2); other site 63737005311 G3 box; other site 63737005312 Switch II region; other site 63737005313 Rab family motif 3 (RabF3); other site 63737005314 Rab family motif 4 (RabF4); other site 63737005315 Rab family motif 5 (RabF5); other site 63737005316 Rab subfamily motif 3 (RabSF3); other site 63737005317 G4 box; other site 63737005318 G5 box; other site 63737005319 Rab subfamily motif 4 (RabSF4); other site 63737005320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737005321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737005322 ATP binding site [chemical binding]; other site 63737005323 Mg2+ binding site [ion binding]; other site 63737005324 G-X-G motif; other site 63737005325 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 63737005326 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 63737005327 putative NAD(P) binding site [chemical binding]; other site 63737005328 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 63737005329 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 63737005330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737005331 FeS/SAM binding site; other site 63737005332 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 63737005333 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 63737005334 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737005335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737005336 S-adenosylmethionine binding site [chemical binding]; other site 63737005337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737005338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005339 active site 63737005340 phosphorylation site [posttranslational modification] 63737005341 intermolecular recognition site; other site 63737005342 dimerization interface [polypeptide binding]; other site 63737005343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737005344 DNA binding site [nucleotide binding] 63737005345 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737005346 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737005347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737005348 S-adenosylmethionine binding site [chemical binding]; other site 63737005349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737005350 Coenzyme A binding pocket [chemical binding]; other site 63737005351 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 63737005352 GIY-YIG motif/motif A; other site 63737005353 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737005354 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737005355 active site 63737005356 ATP binding site [chemical binding]; other site 63737005357 substrate binding site [chemical binding]; other site 63737005358 activation loop (A-loop); other site 63737005359 YARHG domain; Region: YARHG; pfam13308 63737005360 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737005361 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 63737005362 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 63737005363 CAAX protease self-immunity; Region: Abi; pfam02517 63737005364 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 63737005365 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737005366 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737005367 catalytic loop [active] 63737005368 iron binding site [ion binding]; other site 63737005369 TIR domain; Region: TIR_2; pfam13676 63737005370 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 63737005371 GUN4-like; Region: GUN4; pfam05419 63737005372 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737005373 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 63737005374 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 63737005375 substrate binding site [chemical binding]; other site 63737005376 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 63737005377 substrate binding site [chemical binding]; other site 63737005378 ligand binding site [chemical binding]; other site 63737005379 AAA domain; Region: AAA_21; pfam13304 63737005380 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 63737005381 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737005382 Ligand Binding Site [chemical binding]; other site 63737005383 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562 63737005384 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 63737005385 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737005386 iron-sulfur cluster [ion binding]; other site 63737005387 [2Fe-2S] cluster binding site [ion binding]; other site 63737005388 Pirin-related protein [General function prediction only]; Region: COG1741 63737005389 Pirin; Region: Pirin; pfam02678 63737005390 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 63737005391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737005392 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 63737005393 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 63737005394 putative dimer interface [polypeptide binding]; other site 63737005395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737005396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737005397 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 63737005398 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737005399 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737005400 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 63737005401 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 63737005402 Walker A/P-loop; other site 63737005403 ATP binding site [chemical binding]; other site 63737005404 Q-loop/lid; other site 63737005405 ABC transporter signature motif; other site 63737005406 Walker B; other site 63737005407 D-loop; other site 63737005408 H-loop/switch region; other site 63737005409 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 63737005410 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 63737005411 Walker A/P-loop; other site 63737005412 ATP binding site [chemical binding]; other site 63737005413 Q-loop/lid; other site 63737005414 ABC transporter signature motif; other site 63737005415 Walker B; other site 63737005416 D-loop; other site 63737005417 H-loop/switch region; other site 63737005418 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 63737005419 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 63737005420 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 63737005421 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 63737005422 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 63737005423 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 63737005424 HSP70 interaction site [polypeptide binding]; other site 63737005425 Protein of unknown function (DUF938); Region: DUF938; pfam06080 63737005426 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737005427 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737005428 FOG: CBS domain [General function prediction only]; Region: COG0517 63737005429 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 63737005430 CP12 domain; Region: CP12; pfam02672 63737005431 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 63737005432 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737005433 inhibitor-cofactor binding pocket; inhibition site 63737005434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737005435 catalytic residue [active] 63737005436 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 63737005437 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005438 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005439 TPR motif; other site 63737005440 binding surface 63737005441 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005443 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005444 binding surface 63737005445 TPR motif; other site 63737005446 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005449 binding surface 63737005450 TPR motif; other site 63737005451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005454 binding surface 63737005455 TPR motif; other site 63737005456 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005457 TPR repeat; Region: TPR_11; pfam13414 63737005458 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737005459 binding surface 63737005460 TPR motif; other site 63737005461 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737005462 CHAT domain; Region: CHAT; pfam12770 63737005463 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 63737005464 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 63737005465 substrate binding site [chemical binding]; other site 63737005466 catalytic Zn binding site [ion binding]; other site 63737005467 NAD binding site [chemical binding]; other site 63737005468 structural Zn binding site [ion binding]; other site 63737005469 dimer interface [polypeptide binding]; other site 63737005470 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 63737005471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737005472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737005473 homodimer interface [polypeptide binding]; other site 63737005474 catalytic residue [active] 63737005475 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 63737005476 RimM N-terminal domain; Region: RimM; pfam01782 63737005477 PRC-barrel domain; Region: PRC; pfam05239 63737005478 PemK-like protein; Region: PemK; pfam02452 63737005479 putative phosphoketolase; Provisional; Region: PRK05261 63737005480 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 63737005481 TPP-binding site; other site 63737005482 XFP C-terminal domain; Region: XFP_C; pfam09363 63737005483 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 63737005484 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 63737005485 catalytic residue [active] 63737005486 putative FPP diphosphate binding site; other site 63737005487 putative FPP binding hydrophobic cleft; other site 63737005488 dimer interface [polypeptide binding]; other site 63737005489 putative IPP diphosphate binding site; other site 63737005490 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 63737005491 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 63737005492 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 63737005493 Helix-turn-helix domain; Region: HTH_25; pfam13413 63737005494 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737005495 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737005496 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 63737005497 C-terminal domain interface [polypeptide binding]; other site 63737005498 GSH binding site (G-site) [chemical binding]; other site 63737005499 dimer interface [polypeptide binding]; other site 63737005500 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737005501 N-terminal domain interface [polypeptide binding]; other site 63737005502 dimer interface [polypeptide binding]; other site 63737005503 substrate binding pocket (H-site) [chemical binding]; other site 63737005504 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 63737005505 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 63737005506 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 63737005507 substrate binding site [chemical binding]; other site 63737005508 ATP binding site [chemical binding]; other site 63737005509 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 63737005510 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 63737005511 short chain dehydrogenase; Provisional; Region: PRK06179 63737005512 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 63737005513 NADP binding site [chemical binding]; other site 63737005514 active site 63737005515 steroid binding site; other site 63737005516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 63737005517 active site 63737005518 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 63737005519 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 63737005520 LDH/MDH dimer interface [polypeptide binding]; other site 63737005521 NAD(P) binding site [chemical binding]; other site 63737005522 substrate binding site [chemical binding]; other site 63737005523 mercuric reductase; Validated; Region: PRK06370 63737005524 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737005525 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737005526 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 63737005527 SnoaL-like domain; Region: SnoaL_2; pfam12680 63737005528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737005529 Epoxide hydrolase N terminus; Region: EHN; pfam06441 63737005530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 63737005531 MOSC domain; Region: MOSC; pfam03473 63737005532 3-alpha domain; Region: 3-alpha; pfam03475 63737005533 short chain dehydrogenase; Provisional; Region: PRK06500 63737005534 classical (c) SDRs; Region: SDR_c; cd05233 63737005535 NAD(P) binding site [chemical binding]; other site 63737005536 active site 63737005537 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 63737005538 oxidoreductase; Provisional; Region: PRK06196 63737005539 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 63737005540 putative NAD(P) binding site [chemical binding]; other site 63737005541 active site 63737005542 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737005543 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737005544 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737005545 Winged helix-turn helix; Region: HTH_29; pfam13551 63737005546 Homeodomain-like domain; Region: HTH_23; pfam13384 63737005547 Homeodomain-like domain; Region: HTH_32; pfam13565 63737005548 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737005549 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737005550 LysM domain; Region: LysM; pfam01476 63737005551 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 63737005552 catalytic residue [active] 63737005553 LysM domain; Region: LysM; pfam01476 63737005554 Transglycosylase; Region: Transgly; pfam00912 63737005555 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 63737005556 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737005557 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 63737005558 MPN+ (JAMM) motif; other site 63737005559 Zinc-binding site [ion binding]; other site 63737005560 hypothetical protein; Validated; Region: PRK07411 63737005561 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 63737005562 ATP binding site [chemical binding]; other site 63737005563 substrate interface [chemical binding]; other site 63737005564 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 63737005565 active site residue [active] 63737005566 FtsH Extracellular; Region: FtsH_ext; pfam06480 63737005567 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 63737005568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737005569 Walker A motif; other site 63737005570 ATP binding site [chemical binding]; other site 63737005571 Walker B motif; other site 63737005572 arginine finger; other site 63737005573 Peptidase family M41; Region: Peptidase_M41; pfam01434 63737005574 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 63737005575 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 63737005576 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 63737005577 FMN binding site [chemical binding]; other site 63737005578 active site 63737005579 catalytic residues [active] 63737005580 substrate binding site [chemical binding]; other site 63737005581 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 63737005582 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 63737005583 Cupin domain; Region: Cupin_2; cl17218 63737005584 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 63737005585 DNA photolyase; Region: DNA_photolyase; pfam00875 63737005586 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 63737005589 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 63737005590 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737005591 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737005592 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737005593 PAS domain S-box; Region: sensory_box; TIGR00229 63737005594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005595 putative active site [active] 63737005596 heme pocket [chemical binding]; other site 63737005597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005598 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737005599 putative active site [active] 63737005600 heme pocket [chemical binding]; other site 63737005601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005602 putative active site [active] 63737005603 heme pocket [chemical binding]; other site 63737005604 PAS domain S-box; Region: sensory_box; TIGR00229 63737005605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005606 putative active site [active] 63737005607 heme pocket [chemical binding]; other site 63737005608 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005609 PAS fold; Region: PAS_3; pfam08447 63737005610 putative active site [active] 63737005611 heme pocket [chemical binding]; other site 63737005612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737005613 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737005614 dimer interface [polypeptide binding]; other site 63737005615 phosphorylation site [posttranslational modification] 63737005616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737005617 ATP binding site [chemical binding]; other site 63737005618 Mg2+ binding site [ion binding]; other site 63737005619 G-X-G motif; other site 63737005620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005621 Response regulator receiver domain; Region: Response_reg; pfam00072 63737005622 active site 63737005623 phosphorylation site [posttranslational modification] 63737005624 intermolecular recognition site; other site 63737005625 dimerization interface [polypeptide binding]; other site 63737005626 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737005627 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737005628 ligand binding site [chemical binding]; other site 63737005629 flexible hinge region; other site 63737005630 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 63737005631 PAS fold; Region: PAS; pfam00989 63737005632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005633 putative active site [active] 63737005634 heme pocket [chemical binding]; other site 63737005635 Winged helix-turn helix; Region: HTH_29; pfam13551 63737005636 Homeodomain-like domain; Region: HTH_23; pfam13384 63737005637 Homeodomain-like domain; Region: HTH_32; pfam13565 63737005638 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737005639 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737005640 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 63737005641 Winged helix-turn helix; Region: HTH_29; pfam13551 63737005642 Homeodomain-like domain; Region: HTH_23; pfam13384 63737005643 Homeodomain-like domain; Region: HTH_32; pfam13565 63737005644 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737005645 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737005646 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737005647 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737005648 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 63737005649 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 63737005650 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 63737005651 catalytic site [active] 63737005652 active site 63737005653 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 63737005654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737005655 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737005656 active site 63737005657 metal binding site [ion binding]; metal-binding site 63737005658 choline dehydrogenase; Validated; Region: PRK02106 63737005659 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 63737005660 SnoaL-like domain; Region: SnoaL_2; pfam12680 63737005661 Cupin domain; Region: Cupin_2; pfam07883 63737005662 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 63737005663 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 63737005664 H2TH interface [polypeptide binding]; other site 63737005665 putative catalytic residues [active] 63737005666 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 63737005667 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 63737005668 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 63737005669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737005670 PYR/PP interface [polypeptide binding]; other site 63737005671 dimer interface [polypeptide binding]; other site 63737005672 TPP binding site [chemical binding]; other site 63737005673 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737005674 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 63737005675 TPP-binding site [chemical binding]; other site 63737005676 dimer interface [polypeptide binding]; other site 63737005677 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 63737005678 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 63737005679 potential catalytic triad [active] 63737005680 conserved cys residue [active] 63737005681 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 63737005682 intracellular protease, PfpI family; Region: PfpI; TIGR01382 63737005683 conserved cys residue [active] 63737005684 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 63737005685 dimerization interface [polypeptide binding]; other site 63737005686 putative active cleft [active] 63737005687 hypothetical protein; Validated; Region: PRK06840 63737005688 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 63737005689 dimer interface [polypeptide binding]; other site 63737005690 active site 63737005691 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 63737005692 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737005693 PYR/PP interface [polypeptide binding]; other site 63737005694 dimer interface [polypeptide binding]; other site 63737005695 TPP binding site [chemical binding]; other site 63737005696 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737005697 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 63737005698 TPP-binding site [chemical binding]; other site 63737005699 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 63737005700 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 63737005701 acyl-activating enzyme (AAE) consensus motif; other site 63737005702 putative AMP binding site [chemical binding]; other site 63737005703 putative active site [active] 63737005704 putative CoA binding site [chemical binding]; other site 63737005705 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 63737005706 active sites [active] 63737005707 tetramer interface [polypeptide binding]; other site 63737005708 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 63737005709 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 63737005710 dimer interface [polypeptide binding]; other site 63737005711 active site 63737005712 CoA binding pocket [chemical binding]; other site 63737005713 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 63737005714 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 63737005715 dimer interface [polypeptide binding]; other site 63737005716 active site 63737005717 acyl carrier protein; Provisional; Region: acpP; PRK00982 63737005718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 63737005719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 63737005720 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 63737005721 putative hydrophobic ligand binding site [chemical binding]; other site 63737005722 Thioesterase domain; Region: Thioesterase; pfam00975 63737005723 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 63737005724 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737005725 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737005726 active site 63737005727 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737005728 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737005729 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005730 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737005731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737005732 active site 63737005733 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737005734 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737005735 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737005736 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737005737 putative NADP binding site [chemical binding]; other site 63737005738 active site 63737005739 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005740 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737005741 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737005742 active site 63737005743 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737005744 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737005745 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737005746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737005747 S-adenosylmethionine binding site [chemical binding]; other site 63737005748 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737005749 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737005750 putative NADP binding site [chemical binding]; other site 63737005751 active site 63737005752 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737005754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737005755 active site 63737005756 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737005757 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737005758 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737005759 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737005760 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737005761 putative NADP binding site [chemical binding]; other site 63737005762 active site 63737005763 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005764 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 63737005765 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 63737005766 acyl-activating enzyme (AAE) consensus motif; other site 63737005767 active site 63737005768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 63737005769 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 63737005770 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 63737005771 active site 63737005772 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005773 hypothetical protein; Provisional; Region: PRK06185 63737005774 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 63737005775 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 63737005776 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 63737005777 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 63737005778 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 63737005779 Acid Phosphatase; Region: Acid_PPase; cl17256 63737005780 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 63737005781 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 63737005782 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 63737005783 active site 63737005784 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 63737005785 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 63737005786 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005787 Response regulator receiver domain; Region: Response_reg; pfam00072 63737005788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005789 active site 63737005790 phosphorylation site [posttranslational modification] 63737005791 intermolecular recognition site; other site 63737005792 dimerization interface [polypeptide binding]; other site 63737005793 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737005794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 63737005795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737005796 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737005797 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 63737005798 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737005799 PYR/PP interface [polypeptide binding]; other site 63737005800 dimer interface [polypeptide binding]; other site 63737005801 TPP binding site [chemical binding]; other site 63737005802 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737005803 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 63737005804 TPP-binding site [chemical binding]; other site 63737005805 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 63737005806 active site 63737005807 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 63737005808 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 63737005809 active site 63737005810 catalytic triad [active] 63737005811 oxyanion hole [active] 63737005812 short chain dehydrogenase; Provisional; Region: PRK06172 63737005813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737005814 NAD(P) binding site [chemical binding]; other site 63737005815 active site 63737005816 AAA ATPase domain; Region: AAA_16; pfam13191 63737005817 NACHT domain; Region: NACHT; pfam05729 63737005818 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737005819 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737005820 structural tetrad; other site 63737005821 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737005822 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737005823 structural tetrad; other site 63737005824 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737005825 structural tetrad; other site 63737005826 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 63737005827 Winged helix-turn helix; Region: HTH_29; pfam13551 63737005828 Homeodomain-like domain; Region: HTH_23; pfam13384 63737005829 Homeodomain-like domain; Region: HTH_32; pfam13565 63737005830 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737005831 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737005832 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 63737005833 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 63737005834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737005835 NAD(P) binding site [chemical binding]; other site 63737005836 active site 63737005837 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 63737005838 putative FMN binding site [chemical binding]; other site 63737005839 Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534 63737005840 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 63737005841 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737005842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005843 putative active site [active] 63737005844 heme pocket [chemical binding]; other site 63737005845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005846 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737005847 putative active site [active] 63737005848 heme pocket [chemical binding]; other site 63737005849 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737005850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737005851 putative active site [active] 63737005852 heme pocket [chemical binding]; other site 63737005853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737005854 ATP binding site [chemical binding]; other site 63737005855 Mg2+ binding site [ion binding]; other site 63737005856 G-X-G motif; other site 63737005857 Winged helix-turn helix; Region: HTH_29; pfam13551 63737005858 Homeodomain-like domain; Region: HTH_23; pfam13384 63737005859 Homeodomain-like domain; Region: HTH_32; pfam13565 63737005860 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737005861 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737005862 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 63737005863 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 63737005864 dimer interface [polypeptide binding]; other site 63737005865 PYR/PP interface [polypeptide binding]; other site 63737005866 TPP binding site [chemical binding]; other site 63737005867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737005868 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 63737005869 TPP-binding site [chemical binding]; other site 63737005870 dimer interface [polypeptide binding]; other site 63737005871 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 63737005872 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737005873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737005874 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 63737005875 dimer interface [polypeptide binding]; other site 63737005876 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 63737005877 SnoaL-like domain; Region: SnoaL_3; pfam13474 63737005878 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 63737005879 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737005880 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 63737005881 YCII-related domain; Region: YCII; cl00999 63737005882 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 63737005883 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 63737005884 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737005885 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737005886 ligand binding site [chemical binding]; other site 63737005887 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 63737005888 putative catalytic cysteine [active] 63737005889 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 63737005890 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737005891 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737005892 ligand binding site [chemical binding]; other site 63737005893 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737005894 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737005895 DevC protein; Region: devC; TIGR01185 63737005896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737005897 FtsX-like permease family; Region: FtsX; pfam02687 63737005898 DevC protein; Region: devC; TIGR01185 63737005899 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737005900 FtsX-like permease family; Region: FtsX; pfam02687 63737005901 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 63737005902 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737005903 Walker A/P-loop; other site 63737005904 ATP binding site [chemical binding]; other site 63737005905 Q-loop/lid; other site 63737005906 ABC transporter signature motif; other site 63737005907 Walker B; other site 63737005908 D-loop; other site 63737005909 H-loop/switch region; other site 63737005910 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005911 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005912 acyl-CoA synthetase; Validated; Region: PRK05850 63737005913 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 63737005914 acyl-activating enzyme (AAE) consensus motif; other site 63737005915 active site 63737005916 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737005917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 63737005918 AAA ATPase domain; Region: AAA_16; pfam13191 63737005919 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737005920 structural tetrad; other site 63737005921 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737005922 structural tetrad; other site 63737005923 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737005924 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737005925 structural tetrad; other site 63737005926 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 63737005927 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737005928 P loop; other site 63737005929 Nucleotide binding site [chemical binding]; other site 63737005930 DTAP/Switch II; other site 63737005931 Switch I; other site 63737005932 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737005933 DTAP/Switch II; other site 63737005934 Switch I; other site 63737005935 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737005936 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737005937 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737005938 Gas vesicle protein G; Region: GvpG; pfam05120 63737005939 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 63737005940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737005941 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 63737005942 Gas vesicle protein; Region: Gas_vesicle; pfam00741 63737005943 Gas vesicle protein K; Region: GvpK; pfam05121 63737005944 Gas vesicle protein; Region: Gas_vesicle; pfam00741 63737005945 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 63737005946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737005947 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 63737005948 Walker A motif; other site 63737005949 ATP binding site [chemical binding]; other site 63737005950 Walker B motif; other site 63737005951 arginine finger; other site 63737005952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737005953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737005954 Walker A motif; other site 63737005955 ATP binding site [chemical binding]; other site 63737005956 Walker B motif; other site 63737005957 arginine finger; other site 63737005958 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 63737005959 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 63737005960 Response regulator receiver domain; Region: Response_reg; pfam00072 63737005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005962 active site 63737005963 phosphorylation site [posttranslational modification] 63737005964 intermolecular recognition site; other site 63737005965 dimerization interface [polypeptide binding]; other site 63737005966 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737005967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737005968 active site 63737005969 phosphorylation site [posttranslational modification] 63737005970 intermolecular recognition site; other site 63737005971 dimerization interface [polypeptide binding]; other site 63737005972 CheW-like domain; Region: CheW; pfam01584 63737005973 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005974 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005975 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005976 GAF domain; Region: GAF; pfam01590 63737005977 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005978 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005979 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005980 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005981 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005982 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005983 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005984 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005985 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737005986 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737005987 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 63737005988 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 63737005989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737005990 dimer interface [polypeptide binding]; other site 63737005991 putative CheW interface [polypeptide binding]; other site 63737005992 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737005993 putative binding surface; other site 63737005994 active site 63737005995 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 63737005996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737005997 ATP binding site [chemical binding]; other site 63737005998 Mg2+ binding site [ion binding]; other site 63737005999 G-X-G motif; other site 63737006000 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 63737006001 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737006002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006003 active site 63737006004 phosphorylation site [posttranslational modification] 63737006005 intermolecular recognition site; other site 63737006006 dimerization interface [polypeptide binding]; other site 63737006007 CheW-like domain; Region: CheW; pfam01584 63737006008 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 63737006009 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737006010 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737006011 dimer interface [polypeptide binding]; other site 63737006012 putative CheW interface [polypeptide binding]; other site 63737006013 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 63737006014 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 63737006015 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 63737006016 DevC protein; Region: devC; TIGR01185 63737006017 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737006018 FtsX-like permease family; Region: FtsX; pfam02687 63737006019 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737006020 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737006021 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737006022 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 63737006023 putative di-iron ligands [ion binding]; other site 63737006024 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737006025 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 63737006026 putative di-iron ligands [ion binding]; other site 63737006027 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 63737006028 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 63737006029 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 63737006030 putative NAD(P) binding site [chemical binding]; other site 63737006031 active site 63737006032 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 63737006033 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 63737006034 active site 63737006035 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737006036 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737006037 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 63737006038 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722 63737006039 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737006040 active site 63737006041 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 63737006042 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 63737006043 putative NADP binding site [chemical binding]; other site 63737006044 active site 63737006045 Condensation domain; Region: Condensation; pfam00668 63737006046 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006047 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006048 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 63737006049 acyl-activating enzyme (AAE) consensus motif; other site 63737006050 AMP binding site [chemical binding]; other site 63737006051 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006052 Condensation domain; Region: Condensation; pfam00668 63737006053 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006054 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006055 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006056 acyl-activating enzyme (AAE) consensus motif; other site 63737006057 AMP binding site [chemical binding]; other site 63737006058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006059 Condensation domain; Region: Condensation; pfam00668 63737006060 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006061 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006062 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006063 acyl-activating enzyme (AAE) consensus motif; other site 63737006064 AMP binding site [chemical binding]; other site 63737006065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006066 Condensation domain; Region: Condensation; pfam00668 63737006067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006068 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006069 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006070 acyl-activating enzyme (AAE) consensus motif; other site 63737006071 AMP binding site [chemical binding]; other site 63737006072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006073 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737006074 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737006075 active site 63737006076 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737006077 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737006078 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006079 peptide synthase; Provisional; Region: PRK12467 63737006080 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006081 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 63737006082 acyl-activating enzyme (AAE) consensus motif; other site 63737006083 AMP binding site [chemical binding]; other site 63737006084 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006085 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006086 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006087 acyl-activating enzyme (AAE) consensus motif; other site 63737006088 AMP binding site [chemical binding]; other site 63737006089 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006090 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737006091 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006092 acyl-activating enzyme (AAE) consensus motif; other site 63737006093 AMP binding site [chemical binding]; other site 63737006094 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006095 Condensation domain; Region: Condensation; pfam00668 63737006096 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006097 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006098 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006099 acyl-activating enzyme (AAE) consensus motif; other site 63737006100 AMP binding site [chemical binding]; other site 63737006101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006102 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 63737006103 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006105 acyl-activating enzyme (AAE) consensus motif; other site 63737006106 AMP binding site [chemical binding]; other site 63737006107 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006108 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737006109 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 63737006110 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737006111 catalytic Zn binding site [ion binding]; other site 63737006112 structural Zn binding site [ion binding]; other site 63737006113 tetramer interface [polypeptide binding]; other site 63737006114 pyrroline-5-carboxylate reductase; Region: PLN02688 63737006115 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 63737006116 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 63737006117 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 63737006118 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 63737006119 ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185 63737006120 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737006121 ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184 63737006122 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737006123 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 63737006124 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 63737006125 active site 63737006126 nucleophile elbow; other site 63737006127 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 63737006128 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 63737006129 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 63737006130 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 63737006131 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 63737006132 FMN binding site [chemical binding]; other site 63737006133 active site 63737006134 substrate binding site [chemical binding]; other site 63737006135 catalytic residue [active] 63737006136 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737006137 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 63737006138 active site 63737006139 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 63737006140 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 63737006141 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 63737006142 HPP family; Region: HPP; pfam04982 63737006143 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 63737006144 Predicted membrane protein [Function unknown]; Region: COG1808 63737006145 HPP family; Region: HPP; pfam04982 63737006146 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 63737006147 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737006148 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737006149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006150 phosphorylation site [posttranslational modification] 63737006151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006152 ATP binding site [chemical binding]; other site 63737006153 Mg2+ binding site [ion binding]; other site 63737006154 G-X-G motif; other site 63737006155 Electron transfer DM13; Region: DM13; pfam10517 63737006156 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 63737006157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737006158 NAD(P) binding site [chemical binding]; other site 63737006159 active site 63737006160 Predicted flavoprotein [General function prediction only]; Region: COG0431 63737006161 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737006162 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 63737006163 amphipathic channel; other site 63737006164 Asn-Pro-Ala signature motifs; other site 63737006165 Cupin domain; Region: Cupin_2; pfam07883 63737006166 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 63737006167 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 63737006168 FAD binding pocket [chemical binding]; other site 63737006169 FAD binding motif [chemical binding]; other site 63737006170 phosphate binding motif [ion binding]; other site 63737006171 beta-alpha-beta structure motif; other site 63737006172 NAD binding pocket [chemical binding]; other site 63737006173 Heme binding pocket [chemical binding]; other site 63737006174 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737006175 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737006176 catalytic loop [active] 63737006177 iron binding site [ion binding]; other site 63737006178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 63737006179 MOSC domain; Region: MOSC; pfam03473 63737006180 3-alpha domain; Region: 3-alpha; pfam03475 63737006181 Restriction endonuclease; Region: Mrr_cat; pfam04471 63737006182 alpha-glucosidase; Provisional; Region: PRK10137 63737006183 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 63737006184 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 63737006185 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 63737006186 methionine sulfoxide reductase A; Provisional; Region: PRK13014 63737006187 methionine sulfoxide reductase A; Provisional; Region: PRK14054 63737006188 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737006189 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737006190 Winged helix-turn helix; Region: HTH_29; pfam13551 63737006191 Homeodomain-like domain; Region: HTH_23; pfam13384 63737006192 Homeodomain-like domain; Region: HTH_32; pfam13565 63737006193 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737006194 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737006195 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 63737006196 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 63737006197 classical (c) SDRs; Region: SDR_c; cd05233 63737006198 NAD(P) binding site [chemical binding]; other site 63737006199 active site 63737006200 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737006201 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737006202 structural tetrad; other site 63737006203 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 63737006204 Transglycosylase; Region: Transgly; pfam00912 63737006205 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737006206 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 63737006207 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 63737006208 EF-hand domain pair; Region: EF_hand_5; pfam13499 63737006209 Ca2+ binding site [ion binding]; other site 63737006210 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 63737006211 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 63737006212 Predicted membrane protein [Function unknown]; Region: COG1808 63737006213 S-layer homology domain; Region: SLH; pfam00395 63737006214 GXWXG protein; Region: GXWXG; pfam14231 63737006215 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 63737006216 hypothetical protein; Provisional; Region: PRK07236 63737006217 salicylate hydroxylase; Provisional; Region: PRK08163 63737006218 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 63737006219 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737006220 catalytic loop [active] 63737006221 iron binding site [ion binding]; other site 63737006222 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 63737006223 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 63737006224 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 63737006225 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 63737006226 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 63737006227 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 63737006228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 63737006229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 63737006230 TM-ABC transporter signature motif; other site 63737006231 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 63737006232 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 63737006233 Walker A/P-loop; other site 63737006234 ATP binding site [chemical binding]; other site 63737006235 Q-loop/lid; other site 63737006236 ABC transporter signature motif; other site 63737006237 Walker B; other site 63737006238 D-loop; other site 63737006239 H-loop/switch region; other site 63737006240 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 63737006241 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 63737006242 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 63737006243 putative ligand binding site [chemical binding]; other site 63737006244 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 63737006245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737006246 motif II; other site 63737006247 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 63737006248 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 63737006249 putative amidase; Provisional; Region: PRK06169 63737006250 Amidase; Region: Amidase; pfam01425 63737006251 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 63737006252 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 63737006253 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737006254 putative active site [active] 63737006255 AAA ATPase domain; Region: AAA_16; pfam13191 63737006256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737006257 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737006258 TPR motif; other site 63737006259 binding surface 63737006260 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737006261 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006263 active site 63737006264 phosphorylation site [posttranslational modification] 63737006265 intermolecular recognition site; other site 63737006266 dimerization interface [polypeptide binding]; other site 63737006267 PAS domain; Region: PAS; smart00091 63737006268 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737006269 putative active site [active] 63737006270 heme pocket [chemical binding]; other site 63737006271 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006272 dimer interface [polypeptide binding]; other site 63737006273 phosphorylation site [posttranslational modification] 63737006274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006275 ATP binding site [chemical binding]; other site 63737006276 Mg2+ binding site [ion binding]; other site 63737006277 G-X-G motif; other site 63737006278 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006280 active site 63737006281 phosphorylation site [posttranslational modification] 63737006282 intermolecular recognition site; other site 63737006283 dimerization interface [polypeptide binding]; other site 63737006284 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 63737006285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006286 ATP binding site [chemical binding]; other site 63737006287 Mg2+ binding site [ion binding]; other site 63737006288 G-X-G motif; other site 63737006289 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006290 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006291 dimer interface [polypeptide binding]; other site 63737006292 phosphorylation site [posttranslational modification] 63737006293 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006294 ATP binding site [chemical binding]; other site 63737006295 Mg2+ binding site [ion binding]; other site 63737006296 G-X-G motif; other site 63737006297 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006299 active site 63737006300 phosphorylation site [posttranslational modification] 63737006301 intermolecular recognition site; other site 63737006302 dimerization interface [polypeptide binding]; other site 63737006303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006304 active site 63737006305 phosphorylation site [posttranslational modification] 63737006306 intermolecular recognition site; other site 63737006307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 63737006308 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 63737006309 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 63737006310 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 63737006311 ATP binding site [chemical binding]; other site 63737006312 Mg2+ binding site [ion binding]; other site 63737006313 G-X-G motif; other site 63737006314 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 63737006315 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 63737006316 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 63737006317 PAS fold; Region: PAS_4; pfam08448 63737006318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737006319 PAS fold; Region: PAS_3; pfam08447 63737006320 putative active site [active] 63737006321 heme pocket [chemical binding]; other site 63737006322 PAS fold; Region: PAS_4; pfam08448 63737006323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737006324 putative active site [active] 63737006325 heme pocket [chemical binding]; other site 63737006326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006328 dimer interface [polypeptide binding]; other site 63737006329 phosphorylation site [posttranslational modification] 63737006330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006331 ATP binding site [chemical binding]; other site 63737006332 Mg2+ binding site [ion binding]; other site 63737006333 G-X-G motif; other site 63737006334 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737006335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006336 active site 63737006337 phosphorylation site [posttranslational modification] 63737006338 intermolecular recognition site; other site 63737006339 dimerization interface [polypeptide binding]; other site 63737006340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 63737006341 PAS domain; Region: PAS_8; pfam13188 63737006342 PAS domain S-box; Region: sensory_box; TIGR00229 63737006343 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006345 active site 63737006346 phosphorylation site [posttranslational modification] 63737006347 intermolecular recognition site; other site 63737006348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006350 dimer interface [polypeptide binding]; other site 63737006351 phosphorylation site [posttranslational modification] 63737006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006353 ATP binding site [chemical binding]; other site 63737006354 Mg2+ binding site [ion binding]; other site 63737006355 G-X-G motif; other site 63737006356 Protein kinase domain; Region: Pkinase; pfam00069 63737006357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737006358 active site 63737006359 ATP binding site [chemical binding]; other site 63737006360 substrate binding site [chemical binding]; other site 63737006361 activation loop (A-loop); other site 63737006362 AAA ATPase domain; Region: AAA_16; pfam13191 63737006363 Predicted ATPase [General function prediction only]; Region: COG3899 63737006364 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737006365 GAF domain; Region: GAF_3; pfam13492 63737006366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006368 ATP binding site [chemical binding]; other site 63737006369 Mg2+ binding site [ion binding]; other site 63737006370 G-X-G motif; other site 63737006371 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 63737006372 protein I interface; other site 63737006373 D2 interface; other site 63737006374 protein T interface; other site 63737006375 chlorophyll binding site; other site 63737006376 beta carotene binding site; other site 63737006377 pheophytin binding site; other site 63737006378 manganese-stabilizing polypeptide interface; other site 63737006379 CP43 interface; other site 63737006380 protein L interface; other site 63737006381 oxygen evolving complex binding site; other site 63737006382 bromide binding site; other site 63737006383 quinone binding site; other site 63737006384 Fe binding site [ion binding]; other site 63737006385 core light harvesting interface; other site 63737006386 cytochrome b559 alpha subunit interface; other site 63737006387 cytochrome c-550 interface; other site 63737006388 protein J interface; other site 63737006389 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 63737006390 nucleoside/Zn binding site; other site 63737006391 dimer interface [polypeptide binding]; other site 63737006392 catalytic motif [active] 63737006393 Ion transport protein; Region: Ion_trans; pfam00520 63737006394 Ion channel; Region: Ion_trans_2; pfam07885 63737006395 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 63737006396 Double zinc ribbon; Region: DZR; pfam12773 63737006397 S-formylglutathione hydrolase; Region: PLN02442 63737006398 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 63737006399 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 63737006400 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 63737006401 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 63737006402 Right handed beta helix region; Region: Beta_helix; pfam13229 63737006403 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 63737006404 S-layer homology domain; Region: SLH; pfam00395 63737006405 S-layer homology domain; Region: SLH; pfam00395 63737006406 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 63737006407 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 63737006408 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 63737006409 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 63737006410 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 63737006411 Patatin-like phospholipase; Region: Patatin; pfam01734 63737006412 active site 63737006413 nucleophile elbow; other site 63737006414 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 63737006415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737006416 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 63737006417 substrate binding pocket [chemical binding]; other site 63737006418 membrane-bound complex binding site; other site 63737006419 hinge residues; other site 63737006420 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737006421 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 63737006422 short chain dehydrogenase; Validated; Region: PRK06182 63737006423 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 63737006424 NADP binding site [chemical binding]; other site 63737006425 active site 63737006426 steroid binding site; other site 63737006427 Winged helix-turn helix; Region: HTH_29; pfam13551 63737006428 Homeodomain-like domain; Region: HTH_23; pfam13384 63737006429 Homeodomain-like domain; Region: HTH_32; pfam13565 63737006430 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737006431 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737006432 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737006433 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737006434 PemK-like protein; Region: PemK; pfam02452 63737006435 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 63737006436 homoserine kinase; Provisional; Region: PRK01212 63737006437 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 63737006438 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 63737006439 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 63737006440 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 63737006441 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 63737006442 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 63737006443 DNA protecting protein DprA; Region: dprA; TIGR00732 63737006444 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737006445 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 63737006446 active site 63737006447 catalytic triad [active] 63737006448 oxyanion hole [active] 63737006449 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 63737006450 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 63737006451 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 63737006452 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 63737006453 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 63737006454 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 63737006455 ligand binding site [chemical binding]; other site 63737006456 HEAT repeats; Region: HEAT_2; pfam13646 63737006457 Predicted integral membrane protein [Function unknown]; Region: COG5500 63737006458 Isochorismatase family; Region: Isochorismatase; pfam00857 63737006459 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 63737006460 catalytic triad [active] 63737006461 conserved cis-peptide bond; other site 63737006462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737006463 AAA domain; Region: AAA_21; pfam13304 63737006464 Walker A/P-loop; other site 63737006465 ATP binding site [chemical binding]; other site 63737006466 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 63737006467 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737006468 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 63737006469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 63737006470 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 63737006471 Probable transposase; Region: OrfB_IS605; pfam01385 63737006472 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 63737006473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 63737006474 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737006475 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 63737006476 dimer interface [polypeptide binding]; other site 63737006477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 63737006478 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737006479 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 63737006480 dimer interface [polypeptide binding]; other site 63737006481 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737006482 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 63737006483 putative C-terminal domain interface [polypeptide binding]; other site 63737006484 putative GSH binding site (G-site) [chemical binding]; other site 63737006485 putative dimer interface [polypeptide binding]; other site 63737006486 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737006487 dimer interface [polypeptide binding]; other site 63737006488 substrate binding pocket (H-site) [chemical binding]; other site 63737006489 N-terminal domain interface [polypeptide binding]; other site 63737006490 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 63737006491 TIGR02687 family protein; Region: TIGR02687 63737006492 PglZ domain; Region: PglZ; pfam08665 63737006493 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 63737006494 Winged helix-turn helix; Region: HTH_29; pfam13551 63737006495 Homeodomain-like domain; Region: HTH_23; pfam13384 63737006496 Homeodomain-like domain; Region: HTH_32; pfam13565 63737006497 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737006498 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737006499 GAF domain; Region: GAF_3; pfam13492 63737006500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006502 dimer interface [polypeptide binding]; other site 63737006503 phosphorylation site [posttranslational modification] 63737006504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006505 ATP binding site [chemical binding]; other site 63737006506 Mg2+ binding site [ion binding]; other site 63737006507 G-X-G motif; other site 63737006508 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006510 active site 63737006511 phosphorylation site [posttranslational modification] 63737006512 intermolecular recognition site; other site 63737006513 dimerization interface [polypeptide binding]; other site 63737006514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006516 dimer interface [polypeptide binding]; other site 63737006517 phosphorylation site [posttranslational modification] 63737006518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006519 ATP binding site [chemical binding]; other site 63737006520 Mg2+ binding site [ion binding]; other site 63737006521 G-X-G motif; other site 63737006522 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006524 active site 63737006525 phosphorylation site [posttranslational modification] 63737006526 intermolecular recognition site; other site 63737006527 dimerization interface [polypeptide binding]; other site 63737006528 S-layer homology domain; Region: SLH; pfam00395 63737006529 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 63737006530 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 63737006531 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 63737006532 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737006533 catalytic residues [active] 63737006534 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 63737006535 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 63737006536 NAD(P) binding site [chemical binding]; other site 63737006537 homotetramer interface [polypeptide binding]; other site 63737006538 homodimer interface [polypeptide binding]; other site 63737006539 active site 63737006540 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 63737006541 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 63737006542 Chromate transporter; Region: Chromate_transp; pfam02417 63737006543 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 63737006544 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737006545 C-terminal domain interface [polypeptide binding]; other site 63737006546 GSH binding site (G-site) [chemical binding]; other site 63737006547 dimer interface [polypeptide binding]; other site 63737006548 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737006549 N-terminal domain interface [polypeptide binding]; other site 63737006550 Phycobilisome protein; Region: Phycobilisome; cl08227 63737006551 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 63737006552 Protein of unknown function DUF58; Region: DUF58; pfam01882 63737006553 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 63737006554 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 63737006555 Walker A/P-loop; other site 63737006556 ATP binding site [chemical binding]; other site 63737006557 Q-loop/lid; other site 63737006558 ABC transporter signature motif; other site 63737006559 Walker B; other site 63737006560 D-loop; other site 63737006561 H-loop/switch region; other site 63737006562 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 63737006563 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 63737006564 Walker A/P-loop; other site 63737006565 ATP binding site [chemical binding]; other site 63737006566 Q-loop/lid; other site 63737006567 ABC transporter signature motif; other site 63737006568 Walker B; other site 63737006569 D-loop; other site 63737006570 H-loop/switch region; other site 63737006571 NMT1-like family; Region: NMT1_2; pfam13379 63737006572 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 63737006573 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 63737006574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737006575 dimer interface [polypeptide binding]; other site 63737006576 conserved gate region; other site 63737006577 putative PBP binding loops; other site 63737006578 ABC-ATPase subunit interface; other site 63737006579 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 63737006580 NMT1-like family; Region: NMT1_2; pfam13379 63737006581 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737006582 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 63737006583 heterotetramer interface [polypeptide binding]; other site 63737006584 active site pocket [active] 63737006585 cleavage site 63737006586 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 63737006587 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 63737006588 GatB domain; Region: GatB_Yqey; smart00845 63737006589 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 63737006590 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737006591 PAS domain S-box; Region: sensory_box; TIGR00229 63737006592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737006593 PAS domain; Region: PAS_9; pfam13426 63737006594 putative active site [active] 63737006595 heme pocket [chemical binding]; other site 63737006596 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737006597 PAS domain; Region: PAS_9; pfam13426 63737006598 putative active site [active] 63737006599 heme pocket [chemical binding]; other site 63737006600 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737006601 GAF domain; Region: GAF; pfam01590 63737006602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006603 dimer interface [polypeptide binding]; other site 63737006604 phosphorylation site [posttranslational modification] 63737006605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006606 ATP binding site [chemical binding]; other site 63737006607 Mg2+ binding site [ion binding]; other site 63737006608 G-X-G motif; other site 63737006609 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737006610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006611 active site 63737006612 phosphorylation site [posttranslational modification] 63737006613 intermolecular recognition site; other site 63737006614 dimerization interface [polypeptide binding]; other site 63737006615 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006617 active site 63737006618 phosphorylation site [posttranslational modification] 63737006619 intermolecular recognition site; other site 63737006620 dimerization interface [polypeptide binding]; other site 63737006621 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737006622 putative binding surface; other site 63737006623 active site 63737006624 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006626 active site 63737006627 phosphorylation site [posttranslational modification] 63737006628 intermolecular recognition site; other site 63737006629 dimerization interface [polypeptide binding]; other site 63737006630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737006631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737006632 metal binding site [ion binding]; metal-binding site 63737006633 active site 63737006634 I-site; other site 63737006635 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 63737006636 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 63737006637 substrate binding pocket [chemical binding]; other site 63737006638 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737006639 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737006640 Uncharacterized conserved protein [Function unknown]; Region: COG3349 63737006641 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737006642 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737006643 active site 63737006644 ATP binding site [chemical binding]; other site 63737006645 substrate binding site [chemical binding]; other site 63737006646 activation loop (A-loop); other site 63737006647 AAA ATPase domain; Region: AAA_16; pfam13191 63737006648 Predicted ATPase [General function prediction only]; Region: COG3899 63737006649 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737006650 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737006651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737006653 dimer interface [polypeptide binding]; other site 63737006654 phosphorylation site [posttranslational modification] 63737006655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006656 ATP binding site [chemical binding]; other site 63737006657 Mg2+ binding site [ion binding]; other site 63737006658 G-X-G motif; other site 63737006659 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 63737006660 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 63737006661 metal binding site [ion binding]; metal-binding site 63737006662 dimer interface [polypeptide binding]; other site 63737006663 Bacitracin resistance protein BacA; Region: BacA; pfam02673 63737006664 AAA domain; Region: AAA_26; pfam13500 63737006665 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 63737006666 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737006667 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737006668 active site 63737006669 ATP binding site [chemical binding]; other site 63737006670 substrate binding site [chemical binding]; other site 63737006671 activation loop (A-loop); other site 63737006672 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 63737006673 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 63737006674 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737006675 active site 63737006676 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 63737006677 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 63737006678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737006679 dimerization interface [polypeptide binding]; other site 63737006680 GAF domain; Region: GAF_2; pfam13185 63737006681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737006682 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737006683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006684 ATP binding site [chemical binding]; other site 63737006685 Mg2+ binding site [ion binding]; other site 63737006686 G-X-G motif; other site 63737006687 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006689 active site 63737006690 phosphorylation site [posttranslational modification] 63737006691 intermolecular recognition site; other site 63737006692 dimerization interface [polypeptide binding]; other site 63737006693 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006695 active site 63737006696 phosphorylation site [posttranslational modification] 63737006697 intermolecular recognition site; other site 63737006698 Response regulator receiver domain; Region: Response_reg; pfam00072 63737006699 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006700 active site 63737006701 phosphorylation site [posttranslational modification] 63737006702 intermolecular recognition site; other site 63737006703 dimerization interface [polypeptide binding]; other site 63737006704 Predicted methyltransferases [General function prediction only]; Region: COG0313 63737006705 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 63737006706 putative SAM binding site [chemical binding]; other site 63737006707 putative homodimer interface [polypeptide binding]; other site 63737006708 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 63737006709 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 63737006710 substrate binding site [chemical binding]; other site 63737006711 ATP binding site [chemical binding]; other site 63737006712 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 63737006713 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 63737006714 active site 63737006715 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 63737006716 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 63737006717 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 63737006718 HEAT repeats; Region: HEAT_2; pfam13646 63737006719 protein binding surface [polypeptide binding]; other site 63737006720 HEAT repeats; Region: HEAT_2; pfam13646 63737006721 HEAT repeats; Region: HEAT_2; pfam13646 63737006722 HEAT repeats; Region: HEAT_2; pfam13646 63737006723 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 63737006724 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 63737006725 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 63737006726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737006727 Coenzyme A binding pocket [chemical binding]; other site 63737006728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737006729 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737006730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737006731 S-adenosylmethionine binding site [chemical binding]; other site 63737006732 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 63737006733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737006734 motif II; other site 63737006735 putative oxidoreductase; Provisional; Region: PRK08275 63737006736 L-aspartate oxidase; Provisional; Region: PRK06175 63737006737 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 63737006738 antiporter inner membrane protein; Provisional; Region: PRK11670 63737006739 Domain of unknown function DUF59; Region: DUF59; pfam01883 63737006740 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 63737006741 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737006742 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737006743 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 63737006744 Sulfatase; Region: Sulfatase; pfam00884 63737006745 Sodium Bile acid symporter family; Region: SBF; cl17470 63737006746 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 63737006747 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 63737006748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 63737006749 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 63737006750 nucleotide binding site/active site [active] 63737006751 HIT family signature motif; other site 63737006752 catalytic residue [active] 63737006753 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737006754 putative active site [active] 63737006755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 63737006756 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 63737006757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737006758 TPR motif; other site 63737006759 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737006760 binding surface 63737006761 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737006762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737006763 binding surface 63737006764 TPR motif; other site 63737006765 TPR repeat; Region: TPR_11; pfam13414 63737006766 CHAT domain; Region: CHAT; pfam12770 63737006767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737006768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006769 active site 63737006770 phosphorylation site [posttranslational modification] 63737006771 intermolecular recognition site; other site 63737006772 dimerization interface [polypeptide binding]; other site 63737006773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737006774 DNA binding residues [nucleotide binding] 63737006775 dimerization interface [polypeptide binding]; other site 63737006776 Cache domain; Region: Cache_1; pfam02743 63737006777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737006778 dimerization interface [polypeptide binding]; other site 63737006779 PAS domain S-box; Region: sensory_box; TIGR00229 63737006780 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 63737006781 PAS domain S-box; Region: sensory_box; TIGR00229 63737006782 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737006783 putative active site [active] 63737006784 heme pocket [chemical binding]; other site 63737006785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 63737006786 Histidine kinase; Region: HisKA_3; pfam07730 63737006787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006788 ATP binding site [chemical binding]; other site 63737006789 Mg2+ binding site [ion binding]; other site 63737006790 G-X-G motif; other site 63737006791 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 63737006792 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 63737006793 putative NAD(P) binding site [chemical binding]; other site 63737006794 homodimer interface [polypeptide binding]; other site 63737006795 homotetramer interface [polypeptide binding]; other site 63737006796 active site 63737006797 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 63737006798 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 63737006799 active site 63737006800 homodimer interface [polypeptide binding]; other site 63737006801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737006802 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737006803 active site 63737006804 catalytic tetrad [active] 63737006805 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 63737006806 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737006807 NAD binding site [chemical binding]; other site 63737006808 catalytic Zn binding site [ion binding]; other site 63737006809 structural Zn binding site [ion binding]; other site 63737006810 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 63737006811 putative hydrophobic ligand binding site [chemical binding]; other site 63737006812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737006813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737006814 active site 63737006815 phosphorylation site [posttranslational modification] 63737006816 intermolecular recognition site; other site 63737006817 dimerization interface [polypeptide binding]; other site 63737006818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737006819 DNA binding residues [nucleotide binding] 63737006820 dimerization interface [polypeptide binding]; other site 63737006821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 63737006822 Histidine kinase; Region: HisKA_3; pfam07730 63737006823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737006824 ATP binding site [chemical binding]; other site 63737006825 Mg2+ binding site [ion binding]; other site 63737006826 G-X-G motif; other site 63737006827 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 63737006828 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 63737006829 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 63737006830 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 63737006831 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 63737006832 catalytic triad [active] 63737006833 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 63737006834 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 63737006835 Amidinotransferase; Region: Amidinotransf; cl12043 63737006836 Uncharacterized conserved protein [Function unknown]; Region: COG1915 63737006837 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 63737006838 homodimer interface [polypeptide binding]; other site 63737006839 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 63737006840 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 63737006841 Nucleoside recognition; Region: Gate; pfam07670 63737006842 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 63737006843 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 63737006844 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 63737006845 active site 63737006846 putative substrate binding pocket [chemical binding]; other site 63737006847 Isochorismatase family; Region: Isochorismatase; pfam00857 63737006848 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 63737006849 catalytic triad [active] 63737006850 conserved cis-peptide bond; other site 63737006851 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 63737006852 B12 binding domain; Region: B12-binding; pfam02310 63737006853 B12 binding site [chemical binding]; other site 63737006854 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 63737006855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737006856 FeS/SAM binding site; other site 63737006857 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 63737006858 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 63737006859 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 63737006860 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737006861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737006862 NAD(P) binding site [chemical binding]; other site 63737006863 active site 63737006864 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 63737006865 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 63737006866 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 63737006867 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 63737006868 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737006869 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737006870 Calx-beta domain; Region: Calx-beta; cl02522 63737006871 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 63737006872 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 63737006873 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 63737006874 CoA binding domain; Region: CoA_binding; cl17356 63737006875 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 63737006876 NAD(P) binding site [chemical binding]; other site 63737006877 homodimer interface [polypeptide binding]; other site 63737006878 substrate binding site [chemical binding]; other site 63737006879 active site 63737006880 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 63737006881 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 63737006882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737006883 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737006884 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737006885 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 63737006886 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737006887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 63737006888 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 63737006889 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 63737006890 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 63737006891 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 63737006892 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 63737006893 inhibitor-cofactor binding pocket; inhibition site 63737006894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737006895 catalytic residue [active] 63737006896 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737006897 Chain length determinant protein; Region: Wzz; cl15801 63737006898 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 63737006899 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 63737006900 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 63737006901 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 63737006902 trimer interface [polypeptide binding]; other site 63737006903 active site 63737006904 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 63737006905 catalytic site [active] 63737006906 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 63737006907 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 63737006908 tartrate dehydrogenase; Region: TTC; TIGR02089 63737006909 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 63737006910 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 63737006911 substrate binding site [chemical binding]; other site 63737006912 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 63737006913 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 63737006914 substrate binding site [chemical binding]; other site 63737006915 ligand binding site [chemical binding]; other site 63737006916 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006917 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737006918 acyl-activating enzyme (AAE) consensus motif; other site 63737006919 AMP binding site [chemical binding]; other site 63737006920 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006921 Condensation domain; Region: Condensation; pfam00668 63737006922 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006923 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006924 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006925 acyl-activating enzyme (AAE) consensus motif; other site 63737006926 AMP binding site [chemical binding]; other site 63737006927 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006928 Condensation domain; Region: Condensation; pfam00668 63737006929 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737006930 Condensation domain; Region: Condensation; pfam00668 63737006931 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006932 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006933 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 63737006934 acyl-activating enzyme (AAE) consensus motif; other site 63737006935 AMP binding site [chemical binding]; other site 63737006936 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006937 Condensation domain; Region: Condensation; pfam00668 63737006938 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006940 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006941 acyl-activating enzyme (AAE) consensus motif; other site 63737006942 AMP binding site [chemical binding]; other site 63737006943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006944 Condensation domain; Region: Condensation; pfam00668 63737006945 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006946 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006947 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 63737006948 acyl-activating enzyme (AAE) consensus motif; other site 63737006949 AMP binding site [chemical binding]; other site 63737006950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737006951 S-adenosylmethionine binding site [chemical binding]; other site 63737006952 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 63737006953 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006954 Condensation domain; Region: Condensation; pfam00668 63737006955 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737006956 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737006957 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737006958 acyl-activating enzyme (AAE) consensus motif; other site 63737006959 AMP binding site [chemical binding]; other site 63737006960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737006961 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737006962 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 63737006963 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 63737006964 active site 63737006965 catalytic residues [active] 63737006966 metal binding site [ion binding]; metal-binding site 63737006967 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 63737006968 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 63737006969 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 63737006970 GUN4-like; Region: GUN4; pfam05419 63737006971 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737006972 putative active site [active] 63737006973 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737006974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737006975 30S ribosomal protein S1; Reviewed; Region: PRK07400 63737006976 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 63737006977 RNA binding site [nucleotide binding]; other site 63737006978 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 63737006979 RNA binding site [nucleotide binding]; other site 63737006980 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 63737006981 RNA binding site [nucleotide binding]; other site 63737006982 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 63737006983 photosystem II 47 kDa protein; Region: psbB; CHL00062 63737006984 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 63737006985 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 63737006986 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 63737006987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 63737006988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737006989 dimer interface [polypeptide binding]; other site 63737006990 conserved gate region; other site 63737006991 putative PBP binding loops; other site 63737006992 ABC-ATPase subunit interface; other site 63737006993 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 63737006994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 63737006995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737006996 dimer interface [polypeptide binding]; other site 63737006997 conserved gate region; other site 63737006998 putative PBP binding loops; other site 63737006999 ABC-ATPase subunit interface; other site 63737007000 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737007001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737007002 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737007003 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 63737007004 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 63737007005 putative active site [active] 63737007006 HEAT-like repeat; Region: HEAT_EZ; pfam13513 63737007007 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 63737007008 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 63737007009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737007010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737007011 dimer interface [polypeptide binding]; other site 63737007012 phosphorylation site [posttranslational modification] 63737007013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007014 ATP binding site [chemical binding]; other site 63737007015 Mg2+ binding site [ion binding]; other site 63737007016 G-X-G motif; other site 63737007017 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 63737007018 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 63737007019 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 63737007020 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 63737007021 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 63737007022 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 63737007023 amidase; Provisional; Region: PRK09201 63737007024 Amidase; Region: Amidase; cl11426 63737007025 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 63737007026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737007027 Coenzyme A binding pocket [chemical binding]; other site 63737007028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737007029 Coenzyme A binding pocket [chemical binding]; other site 63737007030 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 63737007031 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 63737007032 putative NAD(P) binding site [chemical binding]; other site 63737007033 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737007034 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 63737007035 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737007036 N-terminal domain interface [polypeptide binding]; other site 63737007037 dimer interface [polypeptide binding]; other site 63737007038 substrate binding pocket (H-site) [chemical binding]; other site 63737007039 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737007040 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737007041 active site 63737007042 catalytic tetrad [active] 63737007043 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737007044 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737007045 ligand binding site [chemical binding]; other site 63737007046 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 63737007047 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737007048 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 63737007049 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 63737007050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737007051 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737007052 ligand binding site [chemical binding]; other site 63737007053 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 63737007054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007055 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737007056 active site 63737007057 phosphorylation site [posttranslational modification] 63737007058 intermolecular recognition site; other site 63737007059 dimerization interface [polypeptide binding]; other site 63737007060 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737007061 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 63737007062 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 63737007063 active site 63737007064 homodimer interface [polypeptide binding]; other site 63737007065 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 63737007066 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 63737007067 Walker A motif; other site 63737007068 ATP binding site [chemical binding]; other site 63737007069 Walker B motif; other site 63737007070 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 63737007071 tetramer interface [polypeptide binding]; other site 63737007072 dimer interface [polypeptide binding]; other site 63737007073 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737007074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737007075 S-adenosylmethionine binding site [chemical binding]; other site 63737007076 ferrochelatase; Reviewed; Region: hemH; PRK00035 63737007077 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 63737007078 active site 63737007079 C-terminal domain interface [polypeptide binding]; other site 63737007080 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 63737007081 active site 63737007082 N-terminal domain interface [polypeptide binding]; other site 63737007083 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 63737007084 adenylosuccinate lyase; Provisional; Region: PRK07380 63737007085 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 63737007086 tetramer interface [polypeptide binding]; other site 63737007087 active site 63737007088 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 63737007089 Predicted membrane protein [Function unknown]; Region: COG2323 63737007090 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 63737007091 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 63737007092 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 63737007093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737007094 Walker A motif; other site 63737007095 ATP binding site [chemical binding]; other site 63737007096 Walker B motif; other site 63737007097 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 63737007098 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 63737007099 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 63737007100 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 63737007101 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 63737007102 putative ligand binding site [chemical binding]; other site 63737007103 putative NAD binding site [chemical binding]; other site 63737007104 catalytic site [active] 63737007105 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 63737007106 Double zinc ribbon; Region: DZR; pfam12773 63737007107 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 63737007108 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 63737007109 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737007110 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737007111 phosphopeptide binding site; other site 63737007112 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 63737007113 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 63737007114 putative active site [active] 63737007115 ribonuclease PH; Reviewed; Region: rph; PRK00173 63737007116 Ribonuclease PH; Region: RNase_PH_bact; cd11362 63737007117 hexamer interface [polypeptide binding]; other site 63737007118 active site 63737007119 adenylate kinase; Provisional; Region: adk; PRK02496 63737007120 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 63737007121 AMP-binding site [chemical binding]; other site 63737007122 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 63737007123 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 63737007124 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 63737007125 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 63737007126 trimer interface [polypeptide binding]; other site 63737007127 active site 63737007128 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737007129 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 63737007130 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737007131 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 63737007132 light-harvesting-like protein 3; Provisional; Region: PLN00014 63737007133 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 63737007134 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737007135 putative catalytic residue [active] 63737007136 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 63737007137 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 63737007138 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 63737007139 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 63737007140 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 63737007141 Fasciclin domain; Region: Fasciclin; pfam02469 63737007142 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 63737007143 Biofilm formation and stress response factor; Region: BsmA; cl01794 63737007144 Uncharacterized ACR (DUF711); Region: DUF711; pfam05167 63737007145 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 63737007146 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 63737007147 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 63737007148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737007149 NADH(P)-binding; Region: NAD_binding_10; pfam13460 63737007150 NAD(P) binding site [chemical binding]; other site 63737007151 active site 63737007152 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 63737007153 substrate binding site [chemical binding]; other site 63737007154 active site 63737007155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 63737007156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 63737007157 Methyltransferase domain; Region: Methyltransf_24; pfam13578 63737007158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737007159 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737007160 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737007161 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737007162 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 63737007163 putative ADP-binding pocket [chemical binding]; other site 63737007164 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737007165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737007166 S-adenosylmethionine binding site [chemical binding]; other site 63737007167 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 63737007168 dimer interface [polypeptide binding]; other site 63737007169 catalytic triad [active] 63737007170 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 63737007171 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 63737007172 Aspartase; Region: Aspartase; cd01357 63737007173 active sites [active] 63737007174 tetramer interface [polypeptide binding]; other site 63737007175 Uncharacterized conserved protein [Function unknown]; Region: COG2006 63737007176 Domain of unknown function (DUF362); Region: DUF362; pfam04015 63737007177 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 63737007178 dimer interface [polypeptide binding]; other site 63737007179 substrate binding site [chemical binding]; other site 63737007180 metal binding sites [ion binding]; metal-binding site 63737007181 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 63737007182 tetramerization interface [polypeptide binding]; other site 63737007183 active site 63737007184 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 63737007185 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 63737007186 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737007187 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737007188 protein binding site [polypeptide binding]; other site 63737007189 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 63737007190 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 63737007191 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 63737007192 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737007193 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007194 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007195 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007196 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007197 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007198 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007199 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007200 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 63737007201 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 63737007202 active site 63737007203 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 63737007204 Restriction endonuclease NotI; Region: NotI; pfam12183 63737007205 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 63737007206 DNA methylase; Region: N6_N4_Mtase; pfam01555 63737007207 DNA methylase; Region: N6_N4_Mtase; pfam01555 63737007208 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 63737007209 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 63737007210 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 63737007211 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737007212 catalytic residue [active] 63737007213 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 63737007214 PLD-like domain; Region: PLDc_2; pfam13091 63737007215 putative active site [active] 63737007216 catalytic site [active] 63737007217 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 63737007218 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737007219 non-specific DNA binding site [nucleotide binding]; other site 63737007220 salt bridge; other site 63737007221 sequence-specific DNA binding site [nucleotide binding]; other site 63737007222 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 63737007223 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737007224 cofactor binding site; other site 63737007225 DNA binding site [nucleotide binding] 63737007226 substrate interaction site [chemical binding]; other site 63737007227 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 63737007228 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 63737007229 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 63737007230 Terminase small subunit; Region: Terminase_2; cl01513 63737007231 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 63737007232 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 63737007233 Helix-turn-helix domain; Region: HTH_17; pfam12728 63737007234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 63737007235 active site 63737007236 motif I; other site 63737007237 motif II; other site 63737007238 Replication protein; Region: Rep_1; cl02412 63737007239 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 63737007240 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 63737007241 HD domain; Region: HD_4; pfam13328 63737007242 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 63737007243 ParG; Region: ParG; pfam09274 63737007244 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 63737007245 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 63737007246 catalytic residues [active] 63737007247 catalytic nucleophile [active] 63737007248 Presynaptic Site I dimer interface [polypeptide binding]; other site 63737007249 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 63737007250 Synaptic Flat tetramer interface [polypeptide binding]; other site 63737007251 Synaptic Site I dimer interface [polypeptide binding]; other site 63737007252 DNA binding site [nucleotide binding] 63737007253 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 63737007254 PLD-like domain; Region: PLDc_2; pfam13091 63737007255 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 63737007256 putative active site [active] 63737007257 catalytic site [active] 63737007258 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 63737007259 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 63737007260 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737007261 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 63737007262 putative ADP-binding pocket [chemical binding]; other site 63737007263 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 63737007264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737007265 dimer interface [polypeptide binding]; other site 63737007266 conserved gate region; other site 63737007267 putative PBP binding loops; other site 63737007268 ABC-ATPase subunit interface; other site 63737007269 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737007270 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737007271 active site 63737007272 ATP binding site [chemical binding]; other site 63737007273 substrate binding site [chemical binding]; other site 63737007274 activation loop (A-loop); other site 63737007275 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737007276 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737007277 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 63737007278 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 63737007279 conserved cys residue [active] 63737007280 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 63737007281 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 63737007282 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737007283 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 63737007284 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 63737007285 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 63737007286 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 63737007287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737007288 Walker A/P-loop; other site 63737007289 ATP binding site [chemical binding]; other site 63737007290 Q-loop/lid; other site 63737007291 ABC transporter signature motif; other site 63737007292 Walker B; other site 63737007293 D-loop; other site 63737007294 H-loop/switch region; other site 63737007295 ABC transporter; Region: ABC_tran_2; pfam12848 63737007296 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 63737007297 classical (c) SDRs; Region: SDR_c; cd05233 63737007298 NAD(P) binding site [chemical binding]; other site 63737007299 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 63737007300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737007301 active site 63737007302 motif I; other site 63737007303 motif II; other site 63737007304 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 63737007305 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 63737007306 Walker A/P-loop; other site 63737007307 ATP binding site [chemical binding]; other site 63737007308 Q-loop/lid; other site 63737007309 ABC transporter signature motif; other site 63737007310 Walker B; other site 63737007311 D-loop; other site 63737007312 H-loop/switch region; other site 63737007313 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 63737007314 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 63737007315 Poxvirus F12L protein; Region: Pox_F12L; cl17790 63737007316 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737007317 putative active site [active] 63737007318 Phytochelatin synthase; Region: Phytochelatin; pfam05023 63737007319 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 63737007320 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 63737007321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 63737007322 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737007323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737007324 binding surface 63737007325 TPR motif; other site 63737007326 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737007327 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737007328 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737007329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 63737007330 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 63737007331 Moco binding site; other site 63737007332 metal coordination site [ion binding]; other site 63737007333 dimerization interface [polypeptide binding]; other site 63737007334 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737007335 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737007336 active site 63737007337 ATP binding site [chemical binding]; other site 63737007338 substrate binding site [chemical binding]; other site 63737007339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 63737007340 substrate binding site [chemical binding]; other site 63737007341 activation loop (A-loop); other site 63737007342 activation loop (A-loop); other site 63737007343 AAA ATPase domain; Region: AAA_16; pfam13191 63737007344 Predicted ATPase [General function prediction only]; Region: COG3899 63737007345 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007346 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737007347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737007348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737007349 dimer interface [polypeptide binding]; other site 63737007350 phosphorylation site [posttranslational modification] 63737007351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007352 ATP binding site [chemical binding]; other site 63737007353 Mg2+ binding site [ion binding]; other site 63737007354 G-X-G motif; other site 63737007355 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 63737007356 putative cation:proton antiport protein; Provisional; Region: PRK10669 63737007357 TrkA-N domain; Region: TrkA_N; pfam02254 63737007358 TrkA-C domain; Region: TrkA_C; pfam02080 63737007359 TrkA-C domain; Region: TrkA_C; pfam02080 63737007360 short chain dehydrogenase; Provisional; Region: PRK08303 63737007361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737007362 NAD(P) binding site [chemical binding]; other site 63737007363 active site 63737007364 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 63737007365 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 63737007366 active site 63737007367 metal binding site [ion binding]; metal-binding site 63737007368 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737007369 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737007370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737007371 magnesium chelatase subunit H; Provisional; Region: PLN03241 63737007372 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737007373 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737007374 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 63737007375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007376 dimerization interface [polypeptide binding]; other site 63737007377 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007378 dimerization interface [polypeptide binding]; other site 63737007379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007380 dimerization interface [polypeptide binding]; other site 63737007381 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 63737007382 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007383 dimerization interface [polypeptide binding]; other site 63737007384 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007385 dimerization interface [polypeptide binding]; other site 63737007386 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007387 dimerization interface [polypeptide binding]; other site 63737007388 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 63737007389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007390 dimerization interface [polypeptide binding]; other site 63737007391 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007392 dimerization interface [polypeptide binding]; other site 63737007393 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 63737007394 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007395 dimerization interface [polypeptide binding]; other site 63737007396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007397 dimerization interface [polypeptide binding]; other site 63737007398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007399 dimerization interface [polypeptide binding]; other site 63737007400 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737007401 dimerization interface [polypeptide binding]; other site 63737007402 GAF domain; Region: GAF_2; pfam13185 63737007403 GAF domain; Region: GAF; pfam01590 63737007404 Tropomyosin like; Region: Tropomyosin_1; pfam12718 63737007405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737007406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007407 ATP binding site [chemical binding]; other site 63737007408 Mg2+ binding site [ion binding]; other site 63737007409 G-X-G motif; other site 63737007410 Response regulator receiver domain; Region: Response_reg; pfam00072 63737007411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007412 active site 63737007413 phosphorylation site [posttranslational modification] 63737007414 intermolecular recognition site; other site 63737007415 dimerization interface [polypeptide binding]; other site 63737007416 Response regulator receiver domain; Region: Response_reg; pfam00072 63737007417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007418 active site 63737007419 phosphorylation site [posttranslational modification] 63737007420 intermolecular recognition site; other site 63737007421 dimerization interface [polypeptide binding]; other site 63737007422 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737007423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007424 active site 63737007425 phosphorylation site [posttranslational modification] 63737007426 intermolecular recognition site; other site 63737007427 dimerization interface [polypeptide binding]; other site 63737007428 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 63737007429 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 63737007430 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 63737007431 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 63737007432 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 63737007433 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 63737007434 CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain; Region: Cas3_I-D; cd09710 63737007435 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 63737007436 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 63737007437 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 63737007438 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709 63737007439 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 63737007440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 63737007441 Uncharacterized conserved protein [Function unknown]; Region: COG2442 63737007442 WYL domain; Region: WYL; pfam13280 63737007443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 63737007444 Protein of unknown function (DUF433); Region: DUF433; pfam04255 63737007445 Phosphotransferase enzyme family; Region: APH; pfam01636 63737007446 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 63737007447 active site 63737007448 ATP binding site [chemical binding]; other site 63737007449 substrate binding site [chemical binding]; other site 63737007450 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 63737007451 putative catalytic site [active] 63737007452 putative phosphate binding site [ion binding]; other site 63737007453 active site 63737007454 metal binding site A [ion binding]; metal-binding site 63737007455 DNA binding site [nucleotide binding] 63737007456 putative AP binding site [nucleotide binding]; other site 63737007457 putative metal binding site B [ion binding]; other site 63737007458 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737007459 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 63737007460 putative ADP-binding pocket [chemical binding]; other site 63737007461 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737007462 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 63737007463 NAD(P) binding site [chemical binding]; other site 63737007464 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 63737007465 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 63737007466 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 63737007467 Resolvase, N terminal domain; Region: Resolvase; smart00857 63737007468 catalytic residues [active] 63737007469 Recombinase; Region: Recombinase; pfam07508 63737007470 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 63737007471 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 63737007472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737007473 dimer interface [polypeptide binding]; other site 63737007474 putative metal binding site [ion binding]; other site 63737007475 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 63737007476 putative active site [active] 63737007477 putative metal binding residues [ion binding]; other site 63737007478 signature motif; other site 63737007479 putative dimer interface [polypeptide binding]; other site 63737007480 putative phosphate binding site [ion binding]; other site 63737007481 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 63737007482 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 63737007483 active site 63737007484 FMN binding site [chemical binding]; other site 63737007485 substrate binding site [chemical binding]; other site 63737007486 homotetramer interface [polypeptide binding]; other site 63737007487 catalytic residue [active] 63737007488 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 63737007489 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 63737007490 homodimer interface [polypeptide binding]; other site 63737007491 metal binding site [ion binding]; metal-binding site 63737007492 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 63737007493 homodimer interface [polypeptide binding]; other site 63737007494 active site 63737007495 putative chemical substrate binding site [chemical binding]; other site 63737007496 metal binding site [ion binding]; metal-binding site 63737007497 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 63737007498 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 63737007499 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 63737007500 active site 63737007501 intersubunit interface [polypeptide binding]; other site 63737007502 catalytic residue [active] 63737007503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 63737007504 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 63737007505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 63737007506 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 63737007507 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737007508 putative active site [active] 63737007509 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 63737007510 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 63737007511 homodimer interface [polypeptide binding]; other site 63737007512 putative active site [active] 63737007513 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 63737007514 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 63737007515 nucleotide binding site [chemical binding]; other site 63737007516 putative NEF/HSP70 interaction site [polypeptide binding]; other site 63737007517 SBD interface [polypeptide binding]; other site 63737007518 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 63737007519 putative active site [active] 63737007520 putative catalytic site [active] 63737007521 putative Zn binding site [ion binding]; other site 63737007522 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 63737007523 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 63737007524 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 63737007525 active site 63737007526 Zn binding site [ion binding]; other site 63737007527 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 63737007528 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 63737007529 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 63737007530 putative dimer interface [polypeptide binding]; other site 63737007531 N-terminal domain interface [polypeptide binding]; other site 63737007532 putative substrate binding pocket (H-site) [chemical binding]; other site 63737007533 Galactose oxidase, central domain; Region: Kelch_3; cl02701 63737007534 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 63737007535 Kelch domain; Region: Kelch; smart00612 63737007536 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 63737007537 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 63737007538 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 63737007539 substrate binding site [chemical binding]; other site 63737007540 dimer interface [polypeptide binding]; other site 63737007541 ATP binding site [chemical binding]; other site 63737007542 manganese transport protein MntH; Reviewed; Region: PRK00701 63737007543 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 63737007544 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 63737007545 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 63737007546 Sulfate transporter family; Region: Sulfate_transp; pfam00916 63737007547 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 63737007548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737007549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737007550 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 63737007551 Walker A/P-loop; other site 63737007552 ATP binding site [chemical binding]; other site 63737007553 Q-loop/lid; other site 63737007554 ABC transporter signature motif; other site 63737007555 Walker B; other site 63737007556 D-loop; other site 63737007557 H-loop/switch region; other site 63737007558 Divergent AAA domain; Region: AAA_4; pfam04326 63737007559 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 63737007560 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 63737007561 trimer interface [polypeptide binding]; other site 63737007562 active site 63737007563 substrate binding site [chemical binding]; other site 63737007564 CoA binding site [chemical binding]; other site 63737007565 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737007566 Cytochrome P450; Region: p450; cl12078 63737007567 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737007568 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737007569 P-loop; other site 63737007570 Magnesium ion binding site [ion binding]; other site 63737007571 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737007572 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 63737007573 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 63737007574 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 63737007575 Hexamer interface [polypeptide binding]; other site 63737007576 Hexagonal pore residue; other site 63737007577 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 63737007578 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 63737007579 Hexamer interface [polypeptide binding]; other site 63737007580 Hexagonal pore residue; other site 63737007581 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 63737007582 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 63737007583 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737007584 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737007585 ligand binding site [chemical binding]; other site 63737007586 flexible hinge region; other site 63737007587 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 63737007588 homoserine dehydrogenase; Provisional; Region: PRK06349 63737007589 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 63737007590 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 63737007591 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 63737007592 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 63737007593 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 63737007594 dimerization interface [polypeptide binding]; other site 63737007595 FAD binding pocket [chemical binding]; other site 63737007596 FAD binding motif [chemical binding]; other site 63737007597 catalytic residues [active] 63737007598 NAD binding pocket [chemical binding]; other site 63737007599 phosphate binding motif [ion binding]; other site 63737007600 beta-alpha-beta structure motif; other site 63737007601 phosphoribulokinase; Provisional; Region: PRK07429 63737007602 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 63737007603 active site 63737007604 S-adenosylmethionine synthetase; Validated; Region: PRK05250 63737007605 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 63737007606 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 63737007607 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 63737007608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737007609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737007610 ligand binding site [chemical binding]; other site 63737007611 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737007612 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737007613 ligand binding site [chemical binding]; other site 63737007614 flexible hinge region; other site 63737007615 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 63737007616 substrate binding pocket [chemical binding]; other site 63737007617 substrate-Mg2+ binding site; other site 63737007618 aspartate-rich region 1; other site 63737007619 aspartate-rich region 2; other site 63737007620 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 63737007621 substrate binding pocket [chemical binding]; other site 63737007622 substrate-Mg2+ binding site; other site 63737007623 aspartate-rich region 1; other site 63737007624 aspartate-rich region 2; other site 63737007625 Domain of unknown function DUF39; Region: DUF39; pfam01837 63737007626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737007627 TPR motif; other site 63737007628 binding surface 63737007629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737007630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737007631 binding surface 63737007632 TPR motif; other site 63737007633 TPR repeat; Region: TPR_11; pfam13414 63737007634 Predicted membrane protein [Function unknown]; Region: COG2119 63737007635 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 63737007636 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 63737007637 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 63737007638 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 63737007639 putative NAD(P) binding site [chemical binding]; other site 63737007640 active site 63737007641 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 63737007642 L-aspartate oxidase; Provisional; Region: PRK06175 63737007643 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 63737007644 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 63737007645 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 63737007646 putative ligand binding site [chemical binding]; other site 63737007647 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 63737007648 active site lid residues [active] 63737007649 substrate binding pocket [chemical binding]; other site 63737007650 catalytic residues [active] 63737007651 substrate-Mg2+ binding site; other site 63737007652 aspartate-rich region 1; other site 63737007653 aspartate-rich region 2; other site 63737007654 phytoene desaturase; Region: phytoene_desat; TIGR02731 63737007655 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737007656 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 63737007657 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 63737007658 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 63737007659 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 63737007660 NodB motif; other site 63737007661 active site 63737007662 catalytic site [active] 63737007663 metal binding site [ion binding]; metal-binding site 63737007664 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 63737007665 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 63737007666 active site 63737007667 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007668 GAF domain; Region: GAF; pfam01590 63737007669 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007670 GAF domain; Region: GAF; pfam01590 63737007671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737007672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737007673 dimer interface [polypeptide binding]; other site 63737007674 phosphorylation site [posttranslational modification] 63737007675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007676 ATP binding site [chemical binding]; other site 63737007677 Mg2+ binding site [ion binding]; other site 63737007678 G-X-G motif; other site 63737007679 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 63737007680 putative hydrophobic ligand binding site [chemical binding]; other site 63737007681 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 63737007682 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 63737007683 TrkA-N domain; Region: TrkA_N; pfam02254 63737007684 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737007685 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737007686 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 63737007687 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 63737007688 intrachain domain interface; other site 63737007689 heme bH binding site [chemical binding]; other site 63737007690 heme bL binding site [chemical binding]; other site 63737007691 interchain domain interface [polypeptide binding]; other site 63737007692 Qo binding site; other site 63737007693 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 63737007694 PGAP1-like protein; Region: PGAP1; pfam07819 63737007695 Cytochrome c; Region: Cytochrom_C; cl11414 63737007696 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 63737007697 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 63737007698 plastocyanin; Provisional; Region: PRK02710 63737007699 cytochrome c-550; Provisional; Region: psbV; PRK13618 63737007700 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 63737007701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737007702 dimer interface [polypeptide binding]; other site 63737007703 conserved gate region; other site 63737007704 putative PBP binding loops; other site 63737007705 ABC-ATPase subunit interface; other site 63737007706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737007707 dimer interface [polypeptide binding]; other site 63737007708 conserved gate region; other site 63737007709 putative PBP binding loops; other site 63737007710 ABC-ATPase subunit interface; other site 63737007711 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 63737007712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737007713 Walker A motif; other site 63737007714 ATP binding site [chemical binding]; other site 63737007715 Walker B motif; other site 63737007716 arginine finger; other site 63737007717 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 63737007718 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 63737007719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 63737007720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 63737007721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737007722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737007723 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 63737007724 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 63737007725 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 63737007726 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 63737007727 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 63737007728 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 63737007729 tartrate dehydrogenase; Region: TTC; TIGR02089 63737007730 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 63737007731 Mechanosensitive ion channel; Region: MS_channel; pfam00924 63737007732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 63737007733 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 63737007734 Walker A/P-loop; other site 63737007735 ATP binding site [chemical binding]; other site 63737007736 Q-loop/lid; other site 63737007737 ABC transporter signature motif; other site 63737007738 Walker B; other site 63737007739 D-loop; other site 63737007740 H-loop/switch region; other site 63737007741 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 63737007742 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007743 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737007744 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737007745 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 63737007746 ATP-grasp domain; Region: ATP-grasp; pfam02222 63737007747 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 63737007748 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 63737007749 dimer interface [polypeptide binding]; other site 63737007750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737007751 catalytic residue [active] 63737007752 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 63737007753 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737007754 HSP70 interaction site [polypeptide binding]; other site 63737007755 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 63737007756 active site 63737007757 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 63737007758 active site 63737007759 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737007760 putative active site [active] 63737007761 Protease prsW family; Region: PrsW-protease; cl15823 63737007762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737007763 S-adenosylmethionine binding site [chemical binding]; other site 63737007764 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 63737007765 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 63737007766 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 63737007767 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 63737007768 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 63737007769 Zn binding site [ion binding]; other site 63737007770 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 63737007771 ABC1 family; Region: ABC1; cl17513 63737007772 elongation factor 2; Provisional; Region: PTZ00416 63737007773 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 63737007774 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 63737007775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737007776 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737007777 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737007778 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737007779 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 63737007780 Walker A/P-loop; other site 63737007781 ATP binding site [chemical binding]; other site 63737007782 Q-loop/lid; other site 63737007783 ABC transporter signature motif; other site 63737007784 Walker B; other site 63737007785 D-loop; other site 63737007786 H-loop/switch region; other site 63737007787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737007788 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737007789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737007790 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 63737007791 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 63737007792 ribosomal protein L9; Region: L9; TIGR00158 63737007793 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 63737007794 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 63737007795 replicative DNA helicase; Validated; Region: PRK07773 63737007796 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 63737007797 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 63737007798 Walker A motif; other site 63737007799 ATP binding site [chemical binding]; other site 63737007800 Walker B motif; other site 63737007801 DNA binding loops [nucleotide binding] 63737007802 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 63737007803 protein-splicing catalytic site; other site 63737007804 thioester formation/cholesterol transfer; other site 63737007805 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 63737007806 protein-splicing catalytic site; other site 63737007807 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 63737007808 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 63737007809 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 63737007810 Uncharacterized conserved protein [Function unknown]; Region: COG3937 63737007811 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 63737007812 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 63737007813 Phosphotransferase enzyme family; Region: APH; pfam01636 63737007814 substrate binding site [chemical binding]; other site 63737007815 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737007816 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737007817 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737007818 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737007819 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737007820 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737007821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737007822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737007823 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 63737007824 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 63737007825 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 63737007826 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 63737007827 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 63737007828 active site 63737007829 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007830 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737007831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007832 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737007833 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007834 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737007835 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737007836 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737007837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737007838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737007839 dimer interface [polypeptide binding]; other site 63737007840 phosphorylation site [posttranslational modification] 63737007841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007842 ATP binding site [chemical binding]; other site 63737007843 Mg2+ binding site [ion binding]; other site 63737007844 G-X-G motif; other site 63737007845 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 63737007846 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737007847 putative active site [active] 63737007848 signal recognition particle protein; Provisional; Region: PRK10867 63737007849 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 63737007850 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 63737007851 GTP binding site [chemical binding]; other site 63737007852 Signal peptide binding domain; Region: SRP_SPB; pfam02978 63737007853 ribosomal protein S16; Region: rps16; CHL00005 63737007854 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 63737007855 KH domain; Region: KH_4; pfam13083 63737007856 G-X-X-G motif; other site 63737007857 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 63737007858 PhoH-like protein; Region: PhoH; pfam02562 63737007859 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 63737007860 TIR domain; Region: TIR_2; pfam13676 63737007861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737007862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737007863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737007864 Walker A/P-loop; other site 63737007865 ATP binding site [chemical binding]; other site 63737007866 Q-loop/lid; other site 63737007867 ABC transporter signature motif; other site 63737007868 Walker B; other site 63737007869 D-loop; other site 63737007870 H-loop/switch region; other site 63737007871 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 63737007872 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 63737007873 active site 63737007874 Zn binding site [ion binding]; other site 63737007875 Predicted transcriptional regulators [Transcription]; Region: COG1695 63737007876 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 63737007877 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 63737007878 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 63737007879 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 63737007880 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 63737007881 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 63737007882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 63737007883 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 63737007884 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737007885 catalytic triad [active] 63737007886 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 63737007887 30S subunit binding site; other site 63737007888 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 63737007889 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 63737007890 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 63737007891 Walker A/P-loop; other site 63737007892 ATP binding site [chemical binding]; other site 63737007893 Q-loop/lid; other site 63737007894 ABC transporter signature motif; other site 63737007895 Walker B; other site 63737007896 D-loop; other site 63737007897 H-loop/switch region; other site 63737007898 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737007899 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 63737007900 substrate binding pocket [chemical binding]; other site 63737007901 membrane-bound complex binding site; other site 63737007902 hinge residues; other site 63737007903 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 63737007904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737007905 dimer interface [polypeptide binding]; other site 63737007906 conserved gate region; other site 63737007907 putative PBP binding loops; other site 63737007908 ABC-ATPase subunit interface; other site 63737007909 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737007910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737007911 active site 63737007912 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 63737007913 putative lipid kinase; Reviewed; Region: PRK13057 63737007914 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 63737007915 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737007916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737007917 NAD(P) binding site [chemical binding]; other site 63737007918 active site 63737007919 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 63737007920 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 63737007921 RNA binding surface [nucleotide binding]; other site 63737007922 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 63737007923 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 63737007924 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 63737007925 Walker A motif; other site 63737007926 ATP binding site [chemical binding]; other site 63737007927 Walker B motif; other site 63737007928 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 63737007929 ATP binding site [chemical binding]; other site 63737007930 Walker B motif; other site 63737007931 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 63737007932 tetramer interface [polypeptide binding]; other site 63737007933 dimer interface [polypeptide binding]; other site 63737007934 KaiA domain; Region: KaiA; pfam07688 63737007935 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 63737007936 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737007937 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737007938 dimer interface [polypeptide binding]; other site 63737007939 phosphorylation site [posttranslational modification] 63737007940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007941 ATP binding site [chemical binding]; other site 63737007942 Mg2+ binding site [ion binding]; other site 63737007943 G-X-G motif; other site 63737007944 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007946 active site 63737007947 phosphorylation site [posttranslational modification] 63737007948 intermolecular recognition site; other site 63737007949 dimerization interface [polypeptide binding]; other site 63737007950 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 63737007951 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 63737007952 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 63737007953 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 63737007954 Cl- selectivity filter; other site 63737007955 Cl- binding residues [ion binding]; other site 63737007956 pore gating glutamate residue; other site 63737007957 dimer interface [polypeptide binding]; other site 63737007958 FOG: CBS domain [General function prediction only]; Region: COG0517 63737007959 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 63737007960 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 63737007961 Predicted transcriptional regulator [Transcription]; Region: COG1959 63737007962 Transcriptional regulator; Region: Rrf2; cl17282 63737007963 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 63737007964 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 63737007965 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737007966 active site 63737007967 SnoaL-like domain; Region: SnoaL_3; pfam13474 63737007968 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 63737007969 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737007970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007971 active site 63737007972 phosphorylation site [posttranslational modification] 63737007973 intermolecular recognition site; other site 63737007974 dimerization interface [polypeptide binding]; other site 63737007975 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737007976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737007977 putative active site [active] 63737007978 heme pocket [chemical binding]; other site 63737007979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737007980 dimer interface [polypeptide binding]; other site 63737007981 phosphorylation site [posttranslational modification] 63737007982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737007983 ATP binding site [chemical binding]; other site 63737007984 Mg2+ binding site [ion binding]; other site 63737007985 G-X-G motif; other site 63737007986 Response regulator receiver domain; Region: Response_reg; pfam00072 63737007987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007988 active site 63737007989 phosphorylation site [posttranslational modification] 63737007990 intermolecular recognition site; other site 63737007991 dimerization interface [polypeptide binding]; other site 63737007992 Response regulator receiver domain; Region: Response_reg; pfam00072 63737007993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737007994 active site 63737007995 phosphorylation site [posttranslational modification] 63737007996 intermolecular recognition site; other site 63737007997 dimerization interface [polypeptide binding]; other site 63737007998 Response regulator receiver domain; Region: Response_reg; pfam00072 63737007999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008000 active site 63737008001 phosphorylation site [posttranslational modification] 63737008002 intermolecular recognition site; other site 63737008003 dimerization interface [polypeptide binding]; other site 63737008004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008005 PAS fold; Region: PAS_3; pfam08447 63737008006 putative active site [active] 63737008007 heme pocket [chemical binding]; other site 63737008008 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737008009 GAF domain; Region: GAF; pfam01590 63737008010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008011 PAS fold; Region: PAS_3; pfam08447 63737008012 putative active site [active] 63737008013 heme pocket [chemical binding]; other site 63737008014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008015 PAS fold; Region: PAS_3; pfam08447 63737008016 putative active site [active] 63737008017 heme pocket [chemical binding]; other site 63737008018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737008019 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737008020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008021 dimer interface [polypeptide binding]; other site 63737008022 phosphorylation site [posttranslational modification] 63737008023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008024 ATP binding site [chemical binding]; other site 63737008025 Mg2+ binding site [ion binding]; other site 63737008026 G-X-G motif; other site 63737008027 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 63737008028 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 63737008029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737008030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008031 dimer interface [polypeptide binding]; other site 63737008032 phosphorylation site [posttranslational modification] 63737008033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008034 ATP binding site [chemical binding]; other site 63737008035 Mg2+ binding site [ion binding]; other site 63737008036 G-X-G motif; other site 63737008037 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008039 active site 63737008040 phosphorylation site [posttranslational modification] 63737008041 intermolecular recognition site; other site 63737008042 dimerization interface [polypeptide binding]; other site 63737008043 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008044 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737008045 putative active site [active] 63737008046 heme pocket [chemical binding]; other site 63737008047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008048 putative active site [active] 63737008049 heme pocket [chemical binding]; other site 63737008050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737008051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008052 dimer interface [polypeptide binding]; other site 63737008053 phosphorylation site [posttranslational modification] 63737008054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008055 ATP binding site [chemical binding]; other site 63737008056 Mg2+ binding site [ion binding]; other site 63737008057 G-X-G motif; other site 63737008058 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737008059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008060 active site 63737008061 phosphorylation site [posttranslational modification] 63737008062 intermolecular recognition site; other site 63737008063 dimerization interface [polypeptide binding]; other site 63737008064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 63737008065 Mg2+ binding site [ion binding]; other site 63737008066 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 63737008067 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 63737008068 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 63737008069 generic binding surface II; other site 63737008070 generic binding surface I; other site 63737008071 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 63737008072 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 63737008073 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 63737008074 recombinase A; Provisional; Region: recA; PRK09354 63737008075 hexamer interface [polypeptide binding]; other site 63737008076 Walker A motif; other site 63737008077 ATP binding site [chemical binding]; other site 63737008078 Walker B motif; other site 63737008079 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737008080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737008081 phosphopeptide binding site; other site 63737008082 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737008083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737008084 active site 63737008085 ATP binding site [chemical binding]; other site 63737008086 substrate binding site [chemical binding]; other site 63737008087 activation loop (A-loop); other site 63737008088 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008089 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737008090 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008091 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008092 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 63737008093 substrate binding pocket [chemical binding]; other site 63737008094 substrate-Mg2+ binding site; other site 63737008095 aspartate-rich region 1; other site 63737008096 aspartate-rich region 2; other site 63737008097 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 63737008098 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 63737008099 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 63737008100 putative active site [active] 63737008101 adenylation catalytic residue [active] 63737008102 calmodulin; Provisional; Region: PTZ00184 63737008103 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 63737008104 Ca2+ binding site [ion binding]; other site 63737008105 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 63737008106 Ca2+ binding site [ion binding]; other site 63737008107 Erv1 / Alr family; Region: Evr1_Alr; cl02107 63737008108 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 63737008109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737008110 NAD binding site [chemical binding]; other site 63737008111 substrate binding site [chemical binding]; other site 63737008112 active site 63737008113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737008114 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 63737008115 GAF domain; Region: GAF_2; pfam13185 63737008116 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737008117 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737008118 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737008119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008120 putative active site [active] 63737008121 heme pocket [chemical binding]; other site 63737008122 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 63737008123 cyclase homology domain; Region: CHD; cd07302 63737008124 nucleotidyl binding site; other site 63737008125 metal binding site [ion binding]; metal-binding site 63737008126 dimer interface [polypeptide binding]; other site 63737008127 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 63737008128 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 63737008129 ATP binding site [chemical binding]; other site 63737008130 active site 63737008131 substrate binding site [chemical binding]; other site 63737008132 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 63737008133 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737008134 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 63737008135 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737008136 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 63737008137 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 63737008138 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 63737008139 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 63737008140 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 63737008141 active site 63737008142 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 63737008143 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 63737008144 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 63737008145 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737008146 cofactor binding site; other site 63737008147 DNA binding site [nucleotide binding] 63737008148 substrate interaction site [chemical binding]; other site 63737008149 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737008150 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737008151 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737008152 active site 63737008153 catalytic tetrad [active] 63737008154 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 63737008155 Active_site [active] 63737008156 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737008157 phosphopeptide binding site; other site 63737008158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737008159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737008160 phosphopeptide binding site; other site 63737008161 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737008162 magnesium chelatase subunit H; Provisional; Region: PRK12493 63737008163 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737008164 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 63737008165 XisH protein; Region: XisH; pfam08814 63737008166 XisI protein; Region: XisI; pfam08869 63737008167 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 63737008168 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737008169 non-specific DNA binding site [nucleotide binding]; other site 63737008170 salt bridge; other site 63737008171 sequence-specific DNA binding site [nucleotide binding]; other site 63737008172 LabA_like proteins; Region: LabA_like; cd06167 63737008173 putative metal binding site [ion binding]; other site 63737008174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737008175 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737008176 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 63737008177 ArsC family; Region: ArsC; pfam03960 63737008178 catalytic residue [active] 63737008179 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 63737008180 dimerization interface [polypeptide binding]; other site 63737008181 putative active cleft [active] 63737008182 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 63737008183 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 63737008184 active site 63737008185 Zn binding site [ion binding]; other site 63737008186 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 63737008187 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737008188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737008189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737008190 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737008191 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 63737008192 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 63737008193 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 63737008194 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 63737008195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737008196 flavodoxin FldA; Validated; Region: PRK09267 63737008197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737008198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008199 active site 63737008200 phosphorylation site [posttranslational modification] 63737008201 intermolecular recognition site; other site 63737008202 dimerization interface [polypeptide binding]; other site 63737008203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737008204 DNA binding site [nucleotide binding] 63737008205 Hpt domain; Region: Hpt; pfam01627 63737008206 putative binding surface; other site 63737008207 active site 63737008208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008209 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008210 active site 63737008211 phosphorylation site [posttranslational modification] 63737008212 intermolecular recognition site; other site 63737008213 dimerization interface [polypeptide binding]; other site 63737008214 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008216 active site 63737008217 phosphorylation site [posttranslational modification] 63737008218 intermolecular recognition site; other site 63737008219 dimerization interface [polypeptide binding]; other site 63737008220 Winged helix-turn helix; Region: HTH_29; pfam13551 63737008221 Homeodomain-like domain; Region: HTH_23; pfam13384 63737008222 Homeodomain-like domain; Region: HTH_32; pfam13565 63737008223 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737008224 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737008225 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008227 active site 63737008228 phosphorylation site [posttranslational modification] 63737008229 intermolecular recognition site; other site 63737008230 dimerization interface [polypeptide binding]; other site 63737008231 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 63737008232 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 63737008233 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 63737008234 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 63737008235 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 63737008236 Uncharacterized conserved protein [Function unknown]; Region: COG1479 63737008237 Protein of unknown function DUF262; Region: DUF262; pfam03235 63737008238 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 63737008239 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 63737008240 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737008241 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737008242 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 63737008243 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 63737008244 ring oligomerisation interface [polypeptide binding]; other site 63737008245 ATP/Mg binding site [chemical binding]; other site 63737008246 stacking interactions; other site 63737008247 hinge regions; other site 63737008248 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 63737008249 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 63737008250 putative dimer interface [polypeptide binding]; other site 63737008251 Thioredoxin; Region: Thioredoxin_4; pfam13462 63737008252 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 63737008253 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 63737008254 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 63737008255 nucleotide binding site [chemical binding]; other site 63737008256 NEF interaction site [polypeptide binding]; other site 63737008257 SBD interface [polypeptide binding]; other site 63737008258 ChaB; Region: ChaB; cl01887 63737008259 YfdX protein; Region: YfdX; pfam10938 63737008260 YfdX protein; Region: YfdX; pfam10938 63737008261 chaperone protein DnaJ; Provisional; Region: PRK14299 63737008262 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737008263 HSP70 interaction site [polypeptide binding]; other site 63737008264 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 63737008265 substrate binding site [polypeptide binding]; other site 63737008266 dimer interface [polypeptide binding]; other site 63737008267 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 63737008268 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 63737008269 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 63737008270 Clp amino terminal domain; Region: Clp_N; pfam02861 63737008271 Clp amino terminal domain; Region: Clp_N; pfam02861 63737008272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737008273 Walker A motif; other site 63737008274 ATP binding site [chemical binding]; other site 63737008275 Walker B motif; other site 63737008276 arginine finger; other site 63737008277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737008278 Walker A motif; other site 63737008279 ATP binding site [chemical binding]; other site 63737008280 Walker B motif; other site 63737008281 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 63737008282 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 63737008283 Heat induced stress protein YflT; Region: YflT; pfam11181 63737008284 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 63737008285 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737008286 haemagglutination activity domain; Region: Haemagg_act; pfam05860 63737008287 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737008288 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 63737008289 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737008290 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737008291 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 63737008292 active site 63737008293 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737008294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737008295 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737008296 putative substrate translocation pore; other site 63737008297 Condensation domain; Region: Condensation; pfam00668 63737008298 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008299 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737008300 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008301 acyl-activating enzyme (AAE) consensus motif; other site 63737008302 AMP binding site [chemical binding]; other site 63737008303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008304 Condensation domain; Region: Condensation; pfam00668 63737008305 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008306 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737008307 Condensation domain; Region: Condensation; pfam00668 63737008308 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008309 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008310 acyl-activating enzyme (AAE) consensus motif; other site 63737008311 AMP binding site [chemical binding]; other site 63737008312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008313 Condensation domain; Region: Condensation; pfam00668 63737008314 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008315 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737008316 Condensation domain; Region: Condensation; pfam00668 63737008317 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008318 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008319 acyl-activating enzyme (AAE) consensus motif; other site 63737008320 AMP binding site [chemical binding]; other site 63737008321 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008322 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737008323 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008324 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737008325 active site 63737008326 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737008327 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008328 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 63737008329 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737008330 putative NADP binding site [chemical binding]; other site 63737008331 active site 63737008332 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008333 Condensation domain; Region: Condensation; pfam00668 63737008334 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008335 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737008336 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008337 acyl-activating enzyme (AAE) consensus motif; other site 63737008338 AMP binding site [chemical binding]; other site 63737008339 Condensation domain; Region: Condensation; pfam00668 63737008340 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008341 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008342 acyl-activating enzyme (AAE) consensus motif; other site 63737008343 AMP binding site [chemical binding]; other site 63737008344 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008345 Condensation domain; Region: Condensation; pfam00668 63737008346 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008347 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737008348 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 63737008349 acyl-activating enzyme (AAE) consensus motif; other site 63737008350 AMP binding site [chemical binding]; other site 63737008351 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008352 Condensation domain; Region: Condensation; pfam00668 63737008353 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008354 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008355 acyl-activating enzyme (AAE) consensus motif; other site 63737008356 AMP binding site [chemical binding]; other site 63737008357 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008358 Condensation domain; Region: Condensation; pfam00668 63737008359 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008360 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737008361 Condensation domain; Region: Condensation; pfam00668 63737008362 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008363 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737008364 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008365 acyl-activating enzyme (AAE) consensus motif; other site 63737008366 AMP binding site [chemical binding]; other site 63737008367 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008368 Condensation domain; Region: Condensation; pfam00668 63737008369 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008370 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737008371 Condensation domain; Region: Condensation; pfam00668 63737008372 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008373 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 63737008374 acyl-activating enzyme (AAE) consensus motif; other site 63737008375 AMP binding site [chemical binding]; other site 63737008376 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008377 Condensation domain; Region: Condensation; pfam00668 63737008378 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008379 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737008380 acyl-CoA synthetase; Validated; Region: PRK05850 63737008381 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 63737008382 acyl-activating enzyme (AAE) consensus motif; other site 63737008383 active site 63737008384 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 63737008385 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 63737008386 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008387 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008388 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737008389 active site 63737008390 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737008391 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008392 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008393 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 63737008394 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 63737008395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737008396 catalytic residue [active] 63737008397 Condensation domain; Region: Condensation; pfam00668 63737008398 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008399 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737008400 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008401 acyl-activating enzyme (AAE) consensus motif; other site 63737008402 AMP binding site [chemical binding]; other site 63737008403 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008404 Condensation domain; Region: Condensation; pfam00668 63737008405 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008406 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737008407 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008408 acyl-activating enzyme (AAE) consensus motif; other site 63737008409 AMP binding site [chemical binding]; other site 63737008410 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008411 Condensation domain; Region: Condensation; pfam00668 63737008412 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737008413 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737008414 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 63737008415 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737008416 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737008417 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737008418 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737008419 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 63737008420 FtsX-like permease family; Region: FtsX; pfam02687 63737008421 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 63737008422 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737008423 Walker A/P-loop; other site 63737008424 ATP binding site [chemical binding]; other site 63737008425 Q-loop/lid; other site 63737008426 ABC transporter signature motif; other site 63737008427 Walker B; other site 63737008428 D-loop; other site 63737008429 H-loop/switch region; other site 63737008430 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 63737008431 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737008432 cofactor binding site; other site 63737008433 DNA binding site [nucleotide binding] 63737008434 substrate interaction site [chemical binding]; other site 63737008435 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737008436 GAF domain; Region: GAF; pfam01590 63737008437 GAF domain; Region: GAF_2; pfam13185 63737008438 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 63737008439 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 63737008440 Sulfate transporter family; Region: Sulfate_transp; pfam00916 63737008441 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 63737008442 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737008443 Ligand Binding Site [chemical binding]; other site 63737008444 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737008445 Ligand Binding Site [chemical binding]; other site 63737008446 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 63737008447 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737008448 putative trimer interface [polypeptide binding]; other site 63737008449 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 63737008450 trimer interface [polypeptide binding]; other site 63737008451 active site 63737008452 substrate binding site [chemical binding]; other site 63737008453 putative CoA binding site [chemical binding]; other site 63737008454 CoA binding site [chemical binding]; other site 63737008455 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 63737008456 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 63737008457 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 63737008458 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 63737008459 Cl- selectivity filter; other site 63737008460 Cl- binding residues [ion binding]; other site 63737008461 pore gating glutamate residue; other site 63737008462 dimer interface [polypeptide binding]; other site 63737008463 H+/Cl- coupling transport residue; other site 63737008464 FOG: CBS domain [General function prediction only]; Region: COG0517 63737008465 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 63737008466 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 63737008467 Ligand Binding Site [chemical binding]; other site 63737008468 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737008469 Ligand Binding Site [chemical binding]; other site 63737008470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737008471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737008472 dimerization interface [polypeptide binding]; other site 63737008473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008474 dimer interface [polypeptide binding]; other site 63737008475 phosphorylation site [posttranslational modification] 63737008476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008477 ATP binding site [chemical binding]; other site 63737008478 Mg2+ binding site [ion binding]; other site 63737008479 G-X-G motif; other site 63737008480 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008482 active site 63737008483 phosphorylation site [posttranslational modification] 63737008484 intermolecular recognition site; other site 63737008485 dimerization interface [polypeptide binding]; other site 63737008486 CHASE3 domain; Region: CHASE3; pfam05227 63737008487 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737008488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008489 dimer interface [polypeptide binding]; other site 63737008490 phosphorylation site [posttranslational modification] 63737008491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008492 ATP binding site [chemical binding]; other site 63737008493 Mg2+ binding site [ion binding]; other site 63737008494 G-X-G motif; other site 63737008495 Transglycosylase; Region: Transgly; pfam00912 63737008496 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 63737008497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737008498 Predicted transcriptional regulator [Transcription]; Region: COG1959 63737008499 Transcriptional regulator; Region: Rrf2; pfam02082 63737008500 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 63737008501 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 63737008502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737008503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008504 active site 63737008505 phosphorylation site [posttranslational modification] 63737008506 intermolecular recognition site; other site 63737008507 dimerization interface [polypeptide binding]; other site 63737008508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737008509 DNA binding site [nucleotide binding] 63737008510 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 63737008511 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 63737008512 putative ADP-binding pocket [chemical binding]; other site 63737008513 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 63737008514 Found in ATP-dependent protease La (LON); Region: LON; smart00464 63737008515 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 63737008516 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 63737008517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 63737008518 Zn2+ binding site [ion binding]; other site 63737008519 Mg2+ binding site [ion binding]; other site 63737008520 PRC-barrel domain; Region: PRC; pfam05239 63737008521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 63737008522 S-layer homology domain; Region: SLH; pfam00395 63737008523 S-layer homology domain; Region: SLH; pfam00395 63737008524 S-layer homology domain; Region: SLH; pfam00395 63737008525 Ion transport protein; Region: Ion_trans; pfam00520 63737008526 Ion channel; Region: Ion_trans_2; pfam07885 63737008527 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 63737008528 Mechanosensitive ion channel; Region: MS_channel; pfam00924 63737008529 Predicted membrane protein [Function unknown]; Region: COG4325 63737008530 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 63737008531 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737008532 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737008533 protein binding site [polypeptide binding]; other site 63737008534 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737008535 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737008536 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737008537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008538 active site 63737008539 phosphorylation site [posttranslational modification] 63737008540 intermolecular recognition site; other site 63737008541 dimerization interface [polypeptide binding]; other site 63737008542 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737008543 DNA binding site [nucleotide binding] 63737008544 Hpt domain; Region: Hpt; pfam01627 63737008545 putative binding surface; other site 63737008546 active site 63737008547 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008548 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008550 active site 63737008551 phosphorylation site [posttranslational modification] 63737008552 intermolecular recognition site; other site 63737008553 dimerization interface [polypeptide binding]; other site 63737008554 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 63737008555 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 63737008556 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737008557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008558 putative active site [active] 63737008559 heme pocket [chemical binding]; other site 63737008560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008561 dimer interface [polypeptide binding]; other site 63737008562 phosphorylation site [posttranslational modification] 63737008563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008564 ATP binding site [chemical binding]; other site 63737008565 Mg2+ binding site [ion binding]; other site 63737008566 G-X-G motif; other site 63737008567 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008569 active site 63737008570 phosphorylation site [posttranslational modification] 63737008571 intermolecular recognition site; other site 63737008572 dimerization interface [polypeptide binding]; other site 63737008573 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008575 active site 63737008576 phosphorylation site [posttranslational modification] 63737008577 intermolecular recognition site; other site 63737008578 dimerization interface [polypeptide binding]; other site 63737008579 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 63737008580 PRC-barrel domain; Region: PRC; pfam05239 63737008581 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 63737008582 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737008583 hypothetical protein; Reviewed; Region: PRK12275 63737008584 four helix bundle protein; Region: TIGR02436 63737008585 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737008586 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 63737008587 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 63737008588 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 63737008589 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737008590 NAD binding site [chemical binding]; other site 63737008591 catalytic Zn binding site [ion binding]; other site 63737008592 structural Zn binding site [ion binding]; other site 63737008593 Cupin domain; Region: Cupin_2; cl17218 63737008594 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 63737008595 Domain interface; other site 63737008596 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 63737008597 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 63737008598 short chain dehydrogenase; Provisional; Region: PRK07109 63737008599 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 63737008600 putative NAD(P) binding site [chemical binding]; other site 63737008601 active site 63737008602 Cation efflux family; Region: Cation_efflux; pfam01545 63737008603 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 63737008604 glucose-1-dehydrogenase; Provisional; Region: PRK08936 63737008605 NAD binding site [chemical binding]; other site 63737008606 homodimer interface [polypeptide binding]; other site 63737008607 active site 63737008608 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737008609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737008610 active site 63737008611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737008612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737008613 active site 63737008614 metal binding site [ion binding]; metal-binding site 63737008615 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 63737008616 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 63737008617 Predicted esterase [General function prediction only]; Region: COG0400 63737008618 putative hydrolase; Provisional; Region: PRK11460 63737008619 Winged helix-turn helix; Region: HTH_29; pfam13551 63737008620 Homeodomain-like domain; Region: HTH_23; pfam13384 63737008621 Homeodomain-like domain; Region: HTH_32; pfam13565 63737008622 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737008623 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737008624 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 63737008625 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 63737008626 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 63737008627 IHF dimer interface [polypeptide binding]; other site 63737008628 IHF - DNA interface [nucleotide binding]; other site 63737008629 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 63737008630 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 63737008631 putative dimer interface [polypeptide binding]; other site 63737008632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 63737008633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737008634 Muconolactone delta-isomerase; Region: MIase; cl01992 63737008635 SnoaL-like domain; Region: SnoaL_4; pfam13577 63737008636 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 63737008637 SnoaL-like domain; Region: SnoaL_3; pfam13474 63737008638 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 63737008639 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737008640 Winged helix-turn helix; Region: HTH_29; pfam13551 63737008641 Homeodomain-like domain; Region: HTH_23; pfam13384 63737008642 Homeodomain-like domain; Region: HTH_32; pfam13565 63737008643 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737008644 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737008645 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 63737008646 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737008647 active site 63737008648 DNA binding site [nucleotide binding] 63737008649 Int/Topo IB signature motif; other site 63737008650 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737008651 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737008652 non-specific DNA binding site [nucleotide binding]; other site 63737008653 salt bridge; other site 63737008654 sequence-specific DNA binding site [nucleotide binding]; other site 63737008655 Double zinc ribbon; Region: DZR; pfam12773 63737008656 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 63737008657 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737008658 Walker A/P-loop; other site 63737008659 ATP binding site [chemical binding]; other site 63737008660 Q-loop/lid; other site 63737008661 ABC transporter signature motif; other site 63737008662 Walker B; other site 63737008663 D-loop; other site 63737008664 H-loop/switch region; other site 63737008665 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737008666 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737008667 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008668 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008669 active site 63737008670 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008671 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008672 KR domain; Region: KR; pfam08659 63737008673 putative NADP binding site [chemical binding]; other site 63737008674 active site 63737008675 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008676 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 63737008677 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 63737008678 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 63737008679 tetramer interface [polypeptide binding]; other site 63737008680 TPP-binding site [chemical binding]; other site 63737008681 heterodimer interface [polypeptide binding]; other site 63737008682 phosphorylation loop region [posttranslational modification] 63737008683 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 63737008684 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 63737008685 PYR/PP interface [polypeptide binding]; other site 63737008686 dimer interface [polypeptide binding]; other site 63737008687 TPP binding site [chemical binding]; other site 63737008688 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 63737008689 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 63737008690 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 63737008691 E3 interaction surface; other site 63737008692 lipoyl attachment site [posttranslational modification]; other site 63737008693 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 63737008694 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008695 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008696 active site 63737008697 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008698 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737008699 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008700 KR domain; Region: KR; pfam08659 63737008701 putative NADP binding site [chemical binding]; other site 63737008702 active site 63737008703 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008704 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008705 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008706 active site 63737008707 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008708 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008709 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737008710 putative NADP binding site [chemical binding]; other site 63737008711 active site 63737008712 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008713 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008714 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737008715 active site 63737008716 Acyl transferase domain; Region: Acyl_transf_1; cl08282 63737008717 Acyl transferase domain; Region: Acyl_transf_1; cl08282 63737008718 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 63737008719 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 63737008720 dimer interface [polypeptide binding]; other site 63737008721 active site 63737008722 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 63737008723 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 63737008724 substrate binding site [chemical binding]; other site 63737008725 oxyanion hole (OAH) forming residues; other site 63737008726 trimer interface [polypeptide binding]; other site 63737008727 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 63737008728 substrate binding site [chemical binding]; other site 63737008729 oxyanion hole (OAH) forming residues; other site 63737008730 trimer interface [polypeptide binding]; other site 63737008731 acyl carrier protein; Validated; Region: PRK07117 63737008732 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737008733 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008734 active site 63737008735 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737008736 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008737 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008738 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008739 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008740 active site 63737008741 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008742 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737008743 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008744 putative NADP binding site [chemical binding]; other site 63737008745 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737008746 active site 63737008747 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008748 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008749 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008750 active site 63737008751 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008752 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008753 KR domain; Region: KR; pfam08659 63737008754 putative NADP binding site [chemical binding]; other site 63737008755 active site 63737008756 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008757 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008758 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008759 active site 63737008760 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008761 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737008762 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008763 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737008764 putative NADP binding site [chemical binding]; other site 63737008765 active site 63737008766 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008767 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737008768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737008769 active site 63737008770 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737008771 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737008772 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737008773 KR domain; Region: KR; pfam08659 63737008774 putative NADP binding site [chemical binding]; other site 63737008775 active site 63737008776 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737008777 Condensation domain; Region: Condensation; pfam00668 63737008778 Nonribosomal peptide synthase; Region: NRPS; pfam08415 63737008779 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 63737008780 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737008781 acyl-activating enzyme (AAE) consensus motif; other site 63737008782 AMP binding site [chemical binding]; other site 63737008783 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008784 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737008785 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 63737008786 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737008787 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737008788 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737008789 DevC protein; Region: devC; TIGR01185 63737008790 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737008791 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 63737008792 putative hydrophobic ligand binding site [chemical binding]; other site 63737008793 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 63737008794 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737008795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737008796 WHG domain; Region: WHG; pfam13305 63737008797 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 63737008798 IHF dimer interface [polypeptide binding]; other site 63737008799 IHF - DNA interface [nucleotide binding]; other site 63737008800 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737008801 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737008802 structural tetrad; other site 63737008803 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 63737008804 HEAT repeats; Region: HEAT_2; pfam13646 63737008805 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 63737008806 Response regulator receiver domain; Region: Response_reg; pfam00072 63737008807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008808 active site 63737008809 phosphorylation site [posttranslational modification] 63737008810 intermolecular recognition site; other site 63737008811 dimerization interface [polypeptide binding]; other site 63737008812 Helix-turn-helix domain; Region: HTH_18; pfam12833 63737008813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737008814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008815 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737008816 putative active site [active] 63737008817 heme pocket [chemical binding]; other site 63737008818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008819 dimer interface [polypeptide binding]; other site 63737008820 phosphorylation site [posttranslational modification] 63737008821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008822 ATP binding site [chemical binding]; other site 63737008823 Mg2+ binding site [ion binding]; other site 63737008824 G-X-G motif; other site 63737008825 AAA ATPase domain; Region: AAA_16; pfam13191 63737008826 NACHT domain; Region: NACHT; pfam05729 63737008827 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737008828 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737008829 active site 63737008830 ATP binding site [chemical binding]; other site 63737008831 substrate binding site [chemical binding]; other site 63737008832 activation loop (A-loop); other site 63737008833 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737008834 CHASE2 domain; Region: CHASE2; pfam05226 63737008835 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737008836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 63737008837 haemagglutination activity domain; Region: Haemagg_act; pfam05860 63737008838 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737008839 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737008840 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 63737008841 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 63737008842 active site 63737008843 zinc binding site [ion binding]; other site 63737008844 putative alcohol dehydrogenase; Provisional; Region: PRK13771 63737008845 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 63737008846 NAD(P) binding site [chemical binding]; other site 63737008847 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737008848 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737008849 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737008850 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737008851 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737008852 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 63737008853 Cache domain; Region: Cache_1; pfam02743 63737008854 HAMP domain; Region: HAMP; pfam00672 63737008855 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 63737008856 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 63737008857 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737008858 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737008859 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 63737008860 ligand binding site [chemical binding]; other site 63737008861 flexible hinge region; other site 63737008862 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737008863 ligand binding site [chemical binding]; other site 63737008864 flexible hinge region; other site 63737008865 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 63737008866 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 63737008867 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 63737008868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 63737008869 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 63737008870 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 63737008871 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737008872 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737008873 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737008874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737008875 Coenzyme A binding pocket [chemical binding]; other site 63737008876 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737008877 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737008878 acyl-activating enzyme (AAE) consensus motif; other site 63737008879 AMP binding site [chemical binding]; other site 63737008880 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737008881 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 63737008882 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737008883 putative trimer interface [polypeptide binding]; other site 63737008884 putative CoA binding site [chemical binding]; other site 63737008885 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737008886 putative trimer interface [polypeptide binding]; other site 63737008887 putative CoA binding site [chemical binding]; other site 63737008888 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 63737008889 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737008890 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737008891 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 63737008892 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 63737008893 putative active site [active] 63737008894 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737008895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737008896 Walker A/P-loop; other site 63737008897 ATP binding site [chemical binding]; other site 63737008898 Q-loop/lid; other site 63737008899 ABC transporter signature motif; other site 63737008900 Walker B; other site 63737008901 D-loop; other site 63737008902 H-loop/switch region; other site 63737008903 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 63737008904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737008905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737008906 Walker A/P-loop; other site 63737008907 ATP binding site [chemical binding]; other site 63737008908 Q-loop/lid; other site 63737008909 ABC transporter signature motif; other site 63737008910 Walker B; other site 63737008911 D-loop; other site 63737008912 H-loop/switch region; other site 63737008913 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 63737008914 Ycf27; Reviewed; Region: orf27; CHL00148 63737008915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737008916 active site 63737008917 phosphorylation site [posttranslational modification] 63737008918 intermolecular recognition site; other site 63737008919 dimerization interface [polypeptide binding]; other site 63737008920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737008921 DNA binding site [nucleotide binding] 63737008922 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737008923 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008924 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008925 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737008926 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008927 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737008928 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 63737008929 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 63737008930 active site 63737008931 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 63737008932 active site residue [active] 63737008933 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 63737008934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008935 ATP binding site [chemical binding]; other site 63737008936 Mg2+ binding site [ion binding]; other site 63737008937 G-X-G motif; other site 63737008938 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 63737008939 ATP binding site [chemical binding]; other site 63737008940 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 63737008941 CsbD-like; Region: CsbD; cl17424 63737008942 Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622 63737008943 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 63737008944 TIGR02588 family protein; Region: TIGR02588 63737008945 ChaB; Region: ChaB; pfam06150 63737008946 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 63737008947 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 63737008948 dimerization interface [polypeptide binding]; other site 63737008949 DPS ferroxidase diiron center [ion binding]; other site 63737008950 ion pore; other site 63737008951 Flavivirus RNA-directed RNA polymerase; Region: Flavi_NS5; pfam00972 63737008952 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 63737008953 tellurium resistance terB-like protein; Region: terB_like; cd07177 63737008954 metal binding site [ion binding]; metal-binding site 63737008955 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737008956 GTPase CgtA; Reviewed; Region: obgE; PRK12299 63737008957 GTP1/OBG; Region: GTP1_OBG; pfam01018 63737008958 Obg GTPase; Region: Obg; cd01898 63737008959 G1 box; other site 63737008960 GTP/Mg2+ binding site [chemical binding]; other site 63737008961 Switch I region; other site 63737008962 G2 box; other site 63737008963 G3 box; other site 63737008964 Switch II region; other site 63737008965 G4 box; other site 63737008966 G5 box; other site 63737008967 PAS fold; Region: PAS; pfam00989 63737008968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008969 putative active site [active] 63737008970 heme pocket [chemical binding]; other site 63737008971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008972 PAS domain; Region: PAS_9; pfam13426 63737008973 putative active site [active] 63737008974 heme pocket [chemical binding]; other site 63737008975 PAS domain S-box; Region: sensory_box; TIGR00229 63737008976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008977 putative active site [active] 63737008978 heme pocket [chemical binding]; other site 63737008979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737008980 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 63737008981 putative active site [active] 63737008982 heme pocket [chemical binding]; other site 63737008983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737008984 dimer interface [polypeptide binding]; other site 63737008985 phosphorylation site [posttranslational modification] 63737008986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737008987 ATP binding site [chemical binding]; other site 63737008988 Mg2+ binding site [ion binding]; other site 63737008989 G-X-G motif; other site 63737008990 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 63737008991 metal ion-dependent adhesion site (MIDAS); other site 63737008992 Predicted transcriptional regulators [Transcription]; Region: COG1733 63737008993 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737008994 dimerization interface [polypeptide binding]; other site 63737008995 putative DNA binding site [nucleotide binding]; other site 63737008996 putative Zn2+ binding site [ion binding]; other site 63737008997 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737008998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737008999 S-adenosylmethionine binding site [chemical binding]; other site 63737009000 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 63737009001 Staphylococcal nuclease homologues; Region: SNc; smart00318 63737009002 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 63737009003 Catalytic site; other site 63737009004 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 63737009005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737009006 dimer interface [polypeptide binding]; other site 63737009007 conserved gate region; other site 63737009008 putative PBP binding loops; other site 63737009009 ABC-ATPase subunit interface; other site 63737009010 Caspase domain; Region: Peptidase_C14; pfam00656 63737009011 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737009012 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737009013 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 63737009014 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 63737009015 active site 63737009016 substrate binding site [chemical binding]; other site 63737009017 cosubstrate binding site; other site 63737009018 catalytic site [active] 63737009019 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 63737009020 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 63737009021 NAD(P) binding site [chemical binding]; other site 63737009022 catalytic residues [active] 63737009023 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 63737009024 Predicted amidohydrolase [General function prediction only]; Region: COG0388 63737009025 putative active site [active] 63737009026 catalytic triad [active] 63737009027 putative dimer interface [polypeptide binding]; other site 63737009028 Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747 63737009029 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 63737009030 NADP binding site [chemical binding]; other site 63737009031 active site 63737009032 regulatory binding site [polypeptide binding]; other site 63737009033 Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; cl05747 63737009034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737009035 dimer interface [polypeptide binding]; other site 63737009036 phosphorylation site [posttranslational modification] 63737009037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009038 ATP binding site [chemical binding]; other site 63737009039 Mg2+ binding site [ion binding]; other site 63737009040 G-X-G motif; other site 63737009041 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 63737009042 Transglycosylase; Region: Transgly; pfam00912 63737009043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 63737009044 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 63737009045 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 63737009046 Bacterial Ig-like domain; Region: Big_5; pfam13205 63737009047 MG2 domain; Region: A2M_N; pfam01835 63737009048 Alpha-2-macroglobulin family; Region: A2M; pfam00207 63737009049 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 63737009050 surface patch; other site 63737009051 specificity defining residues; other site 63737009052 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 63737009053 active site 63737009054 putative homodimer interface [polypeptide binding]; other site 63737009055 SAM binding site [chemical binding]; other site 63737009056 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 63737009057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009058 S-adenosylmethionine binding site [chemical binding]; other site 63737009059 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 63737009060 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 63737009061 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 63737009062 active site 63737009063 catalytic triad [active] 63737009064 oxyanion hole [active] 63737009065 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 63737009066 hypothetical protein; Provisional; Region: PRK02237 63737009067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737009068 GAF domain; Region: GAF; pfam01590 63737009069 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 63737009070 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 63737009071 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737009072 putative binding surface; other site 63737009073 active site 63737009074 RNA polymerase sigma factor; Validated; Region: PRK05949 63737009075 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737009076 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737009077 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737009078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737009079 DNA binding residues [nucleotide binding] 63737009080 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 63737009081 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 63737009082 ATP binding site [chemical binding]; other site 63737009083 substrate interface [chemical binding]; other site 63737009084 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 63737009085 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 63737009086 Walker A/P-loop; other site 63737009087 ATP binding site [chemical binding]; other site 63737009088 Q-loop/lid; other site 63737009089 ABC transporter signature motif; other site 63737009090 Walker B; other site 63737009091 D-loop; other site 63737009092 H-loop/switch region; other site 63737009093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 63737009094 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 63737009095 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 63737009096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737009097 dimer interface [polypeptide binding]; other site 63737009098 conserved gate region; other site 63737009099 putative PBP binding loops; other site 63737009100 ABC-ATPase subunit interface; other site 63737009101 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 63737009102 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 63737009103 homodimer interface [polypeptide binding]; other site 63737009104 ligand binding site [chemical binding]; other site 63737009105 NAD binding site [chemical binding]; other site 63737009106 catalytic site [active] 63737009107 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 63737009108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737009109 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 63737009110 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 63737009111 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 63737009112 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 63737009113 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 63737009114 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737009115 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737009116 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737009117 DNA binding residues [nucleotide binding] 63737009118 dimerization interface [polypeptide binding]; other site 63737009119 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737009120 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737009121 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 63737009122 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737009123 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737009124 protein binding site [polypeptide binding]; other site 63737009125 Putative transcription activator [Transcription]; Region: TenA; COG0819 63737009126 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 63737009127 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 63737009128 active site 63737009129 zinc binding site [ion binding]; other site 63737009130 HEAT repeats; Region: HEAT_2; pfam13646 63737009131 HEAT repeats; Region: HEAT_2; pfam13646 63737009132 putative pectinesterase; Region: PLN02432; cl01911 63737009133 Right handed beta helix region; Region: Beta_helix; pfam13229 63737009134 Right handed beta helix region; Region: Beta_helix; pfam13229 63737009135 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009136 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737009137 RNA helicase; Region: RNA_helicase; pfam00910 63737009138 Walker A motif; other site 63737009139 ATP binding site [chemical binding]; other site 63737009140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009141 Walker B motif; other site 63737009142 arginine finger; other site 63737009143 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737009144 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 63737009145 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 63737009146 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 63737009147 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 63737009148 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 63737009149 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 63737009150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009151 S-adenosylmethionine binding site [chemical binding]; other site 63737009152 CHAT domain; Region: CHAT; pfam12770 63737009153 Caspase domain; Region: Peptidase_C14; pfam00656 63737009154 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 63737009155 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 63737009156 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 63737009157 AAA ATPase domain; Region: AAA_16; pfam13191 63737009158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737009159 TPR motif; other site 63737009160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737009161 binding surface 63737009162 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737009163 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737009164 Uncharacterized conserved protein [Function unknown]; Region: COG4278 63737009165 CHAT domain; Region: CHAT; pfam12770 63737009166 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 63737009167 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 63737009168 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 63737009169 four helix bundle protein; Region: TIGR02436 63737009170 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 63737009171 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 63737009172 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737009173 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737009174 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737009175 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737009176 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737009177 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737009178 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 63737009179 acyl-CoA synthetase; Validated; Region: PRK05850 63737009180 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 63737009181 acyl-activating enzyme (AAE) consensus motif; other site 63737009182 active site 63737009183 Phosphopantetheine attachment site; Region: PP-binding; cl09936 63737009184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009185 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737009186 active site 63737009187 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737009188 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009189 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737009190 KR domain; Region: KR; pfam08659 63737009191 putative NADP binding site [chemical binding]; other site 63737009192 active site 63737009193 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737009194 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737009195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009196 active site 63737009197 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009198 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737009199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737009200 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 63737009201 Enoylreductase; Region: PKS_ER; smart00829 63737009202 NAD(P) binding site [chemical binding]; other site 63737009203 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737009204 KR domain; Region: KR; pfam08659 63737009205 putative NADP binding site [chemical binding]; other site 63737009206 active site 63737009207 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737009208 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009209 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737009210 active site 63737009211 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737009212 short chain dehydrogenase; Provisional; Region: PRK07825 63737009213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737009214 NAD(P) binding site [chemical binding]; other site 63737009215 active site 63737009216 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 63737009217 FAD binding domain; Region: FAD_binding_4; pfam01565 63737009218 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 63737009219 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737009220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737009221 NAD(P) binding site [chemical binding]; other site 63737009222 active site 63737009223 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 63737009224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737009225 NAD(P) binding site [chemical binding]; other site 63737009226 active site 63737009227 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 63737009228 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 63737009229 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 63737009230 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 63737009231 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 63737009232 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737009233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009234 S-adenosylmethionine binding site [chemical binding]; other site 63737009235 Beta-propeller repeat; Region: SBBP; pfam06739 63737009236 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737009237 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737009238 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737009239 DevC protein; Region: devC; TIGR01185 63737009240 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737009241 FtsX-like permease family; Region: FtsX; pfam02687 63737009242 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 63737009243 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 63737009244 catalytic residues [active] 63737009245 catalytic nucleophile [active] 63737009246 Presynaptic Site I dimer interface [polypeptide binding]; other site 63737009247 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 63737009248 Synaptic Flat tetramer interface [polypeptide binding]; other site 63737009249 Synaptic Site I dimer interface [polypeptide binding]; other site 63737009250 DNA binding site [nucleotide binding] 63737009251 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 63737009252 DNA-binding interface [nucleotide binding]; DNA binding site 63737009253 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737009254 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737009255 ligand binding site [chemical binding]; other site 63737009256 flexible hinge region; other site 63737009257 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 63737009258 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 63737009259 putative active site [active] 63737009260 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737009261 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 63737009262 Walker A/P-loop; other site 63737009263 ATP binding site [chemical binding]; other site 63737009264 Q-loop/lid; other site 63737009265 ABC transporter signature motif; other site 63737009266 Walker B; other site 63737009267 D-loop; other site 63737009268 H-loop/switch region; other site 63737009269 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 63737009270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 63737009271 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737009272 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 63737009273 SurA N-terminal domain; Region: SurA_N; pfam09312 63737009274 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 63737009275 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 63737009276 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 63737009277 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 63737009278 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 63737009279 active site 63737009280 catalytic tetrad [active] 63737009281 Phosphotransferase enzyme family; Region: APH; pfam01636 63737009282 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 63737009283 nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103 63737009284 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737009285 FeS/SAM binding site; other site 63737009286 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 63737009287 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737009288 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737009289 active site 63737009290 DNA binding site [nucleotide binding] 63737009291 Int/Topo IB signature motif; other site 63737009292 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 63737009293 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 63737009294 T5orf172 domain; Region: T5orf172; pfam10544 63737009295 Predicted peptidase [General function prediction only]; Region: COG4099 63737009296 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 63737009297 Winged helix-turn helix; Region: HTH_29; pfam13551 63737009298 Homeodomain-like domain; Region: HTH_23; pfam13384 63737009299 Homeodomain-like domain; Region: HTH_32; pfam13565 63737009300 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737009301 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737009302 Penicillin amidase; Region: Penicil_amidase; pfam01804 63737009303 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 63737009304 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 63737009305 active site 63737009306 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 63737009307 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 63737009308 MbtH-like protein; Region: MbtH; cl01279 63737009309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737009310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737009311 active site 63737009312 catalytic tetrad [active] 63737009313 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737009314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009315 S-adenosylmethionine binding site [chemical binding]; other site 63737009316 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737009317 active site 63737009318 iron coordination sites [ion binding]; other site 63737009319 substrate binding pocket [chemical binding]; other site 63737009320 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009321 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737009322 active site 63737009323 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737009324 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009325 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 63737009326 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737009327 putative NADP binding site [chemical binding]; other site 63737009328 active site 63737009329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009330 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737009331 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737009332 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009333 active site 63737009334 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009335 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 63737009336 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737009337 inhibitor-cofactor binding pocket; inhibition site 63737009338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737009339 catalytic residue [active] 63737009340 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009341 Condensation domain; Region: Condensation; pfam00668 63737009342 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737009343 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737009344 acyl-activating enzyme (AAE) consensus motif; other site 63737009345 AMP binding site [chemical binding]; other site 63737009346 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009347 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 63737009348 Condensation domain; Region: Condensation; pfam00668 63737009349 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009350 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737009351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009352 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737009353 active site 63737009354 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737009355 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009356 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737009357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009358 S-adenosylmethionine binding site [chemical binding]; other site 63737009359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737009360 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 63737009361 putative NADP binding site [chemical binding]; other site 63737009362 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 63737009363 active site 63737009364 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009365 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009366 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 63737009367 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737009368 inhibitor-cofactor binding pocket; inhibition site 63737009369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737009370 catalytic residue [active] 63737009371 Condensation domain; Region: Condensation; pfam00668 63737009372 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009373 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737009374 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737009375 acyl-activating enzyme (AAE) consensus motif; other site 63737009376 AMP binding site [chemical binding]; other site 63737009377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009378 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009379 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737009380 active site 63737009381 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737009382 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009383 Condensation domain; Region: Condensation; pfam00668 63737009384 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009385 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737009386 acyl-activating enzyme (AAE) consensus motif; other site 63737009387 AMP binding site [chemical binding]; other site 63737009388 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737009390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009391 S-adenosylmethionine binding site [chemical binding]; other site 63737009392 Condensation domain; Region: Condensation; pfam00668 63737009393 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009394 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009395 Condensation domain; Region: Condensation; pfam00668 63737009396 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009397 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737009398 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737009399 Condensation domain; Region: Condensation; pfam00668 63737009400 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737009401 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737009402 acyl-activating enzyme (AAE) consensus motif; other site 63737009403 AMP binding site [chemical binding]; other site 63737009404 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009405 Condensation domain; Region: Condensation; pfam00668 63737009406 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 63737009407 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737009408 Condensation domain; Region: Condensation; pfam00668 63737009409 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009410 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737009411 FkbH-like domain; Region: FkbH; TIGR01686 63737009412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737009413 active site 63737009414 motif I; other site 63737009415 motif II; other site 63737009416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 63737009417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 63737009418 active site 63737009419 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 63737009420 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 63737009421 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 63737009422 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 63737009423 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737009424 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737009425 active site 63737009426 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737009427 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737009428 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009429 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 63737009430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737009431 inhibitor-cofactor binding pocket; inhibition site 63737009432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737009433 catalytic residue [active] 63737009434 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 63737009435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737009436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009437 S-adenosylmethionine binding site [chemical binding]; other site 63737009438 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737009439 active site 63737009440 iron coordination sites [ion binding]; other site 63737009441 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 63737009442 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 63737009443 homodimer interface [polypeptide binding]; other site 63737009444 active site 63737009445 TDP-binding site; other site 63737009446 acceptor substrate-binding pocket; other site 63737009447 Condensation domain; Region: Condensation; pfam00668 63737009448 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737009449 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737009450 acyl-activating enzyme (AAE) consensus motif; other site 63737009451 AMP binding site [chemical binding]; other site 63737009452 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737009453 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737009454 acyl-CoA synthetase; Validated; Region: PRK05850 63737009455 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 63737009456 acyl-activating enzyme (AAE) consensus motif; other site 63737009457 active site 63737009458 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737009459 Condensation domain; Region: Condensation; pfam00668 63737009460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737009461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737009462 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 63737009463 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 63737009464 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 63737009465 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 63737009466 AMIN domain; Region: AMIN; pfam11741 63737009467 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 63737009468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 63737009469 N-terminal plug; other site 63737009470 ligand-binding site [chemical binding]; other site 63737009471 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737009472 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737009473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737009474 TPR repeat; Region: TPR_11; pfam13414 63737009475 binding surface 63737009476 TPR motif; other site 63737009477 Methyltransferase domain; Region: Methyltransf_24; pfam13578 63737009478 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 63737009479 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 63737009480 dimer interface [polypeptide binding]; other site 63737009481 anticodon binding site; other site 63737009482 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 63737009483 homodimer interface [polypeptide binding]; other site 63737009484 motif 1; other site 63737009485 active site 63737009486 motif 2; other site 63737009487 GAD domain; Region: GAD; pfam02938 63737009488 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 63737009489 motif 3; other site 63737009490 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 63737009491 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 63737009492 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737009493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009494 Walker A motif; other site 63737009495 ATP binding site [chemical binding]; other site 63737009496 Walker B motif; other site 63737009497 arginine finger; other site 63737009498 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 63737009499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737009500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737009501 active site 63737009502 ATP binding site [chemical binding]; other site 63737009503 substrate binding site [chemical binding]; other site 63737009504 activation loop (A-loop); other site 63737009505 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737009506 short chain dehydrogenase; Provisional; Region: PRK06701 63737009507 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 63737009508 NAD binding site [chemical binding]; other site 63737009509 metal binding site [ion binding]; metal-binding site 63737009510 active site 63737009511 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 63737009512 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 63737009513 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 63737009514 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 63737009515 Calx-beta domain; Region: Calx-beta; pfam03160 63737009516 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 63737009517 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 63737009518 mercuric reductase; Validated; Region: PRK06370 63737009519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737009520 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737009521 Uncharacterized conserved protein [Function unknown]; Region: COG0398 63737009522 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 63737009523 Uncharacterized conserved protein [Function unknown]; Region: COG0398 63737009524 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 63737009525 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 63737009526 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 63737009527 Probable Catalytic site; other site 63737009528 Caspase domain; Region: Peptidase_C14; pfam00656 63737009529 AAA ATPase domain; Region: AAA_16; pfam13191 63737009530 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737009531 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737009532 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737009533 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 63737009534 Predicted membrane protein [Function unknown]; Region: COG4270 63737009535 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 63737009536 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737009537 putative Mg++ binding site [ion binding]; other site 63737009538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737009539 nucleotide binding region [chemical binding]; other site 63737009540 ATP-binding site [chemical binding]; other site 63737009541 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 63737009542 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737009543 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 63737009544 putative NAD(P) binding site [chemical binding]; other site 63737009545 active site 63737009546 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 63737009547 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737009548 putative ADP-binding pocket [chemical binding]; other site 63737009549 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737009550 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 63737009551 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 63737009552 NADP-binding site; other site 63737009553 homotetramer interface [polypeptide binding]; other site 63737009554 substrate binding site [chemical binding]; other site 63737009555 homodimer interface [polypeptide binding]; other site 63737009556 active site 63737009557 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 63737009558 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 63737009559 NADP binding site [chemical binding]; other site 63737009560 active site 63737009561 putative substrate binding site [chemical binding]; other site 63737009562 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 63737009563 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 63737009564 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 63737009565 putative heme binding pocket [chemical binding]; other site 63737009566 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 63737009567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737009568 dimer interface [polypeptide binding]; other site 63737009569 conserved gate region; other site 63737009570 putative PBP binding loops; other site 63737009571 ABC-ATPase subunit interface; other site 63737009572 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737009573 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737009574 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737009575 ligand binding site [chemical binding]; other site 63737009576 flexible hinge region; other site 63737009577 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 63737009578 putative switch regulator; other site 63737009579 non-specific DNA interactions [nucleotide binding]; other site 63737009580 DNA binding site [nucleotide binding] 63737009581 sequence specific DNA binding site [nucleotide binding]; other site 63737009582 putative cAMP binding site [chemical binding]; other site 63737009583 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 63737009584 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 63737009585 putative dimer interface [polypeptide binding]; other site 63737009586 active site pocket [active] 63737009587 putative cataytic base [active] 63737009588 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 63737009589 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 63737009590 Phosphoesterase family; Region: Phosphoesterase; pfam04185 63737009591 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 63737009592 Peptidase family U32; Region: Peptidase_U32; pfam01136 63737009593 Collagenase; Region: DUF3656; pfam12392 63737009594 Peptidase family U32; Region: Peptidase_U32; cl03113 63737009595 YcfA-like protein; Region: YcfA; pfam07927 63737009596 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 63737009597 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 63737009598 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 63737009599 amidase catalytic site [active] 63737009600 Zn binding residues [ion binding]; other site 63737009601 substrate binding site [chemical binding]; other site 63737009602 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 63737009603 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 63737009604 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 63737009605 dimerization interface [polypeptide binding]; other site 63737009606 active site 63737009607 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 63737009608 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 63737009609 enolase; Provisional; Region: eno; PRK00077 63737009610 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 63737009611 dimer interface [polypeptide binding]; other site 63737009612 metal binding site [ion binding]; metal-binding site 63737009613 substrate binding pocket [chemical binding]; other site 63737009614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737009615 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 63737009616 dimer interface [polypeptide binding]; other site 63737009617 active site 63737009618 metal binding site [ion binding]; metal-binding site 63737009619 glutathione binding site [chemical binding]; other site 63737009620 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 63737009621 Clp amino terminal domain; Region: Clp_N; pfam02861 63737009622 Clp amino terminal domain; Region: Clp_N; pfam02861 63737009623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009624 Walker A motif; other site 63737009625 ATP binding site [chemical binding]; other site 63737009626 Walker B motif; other site 63737009627 arginine finger; other site 63737009628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009629 Walker A motif; other site 63737009630 ATP binding site [chemical binding]; other site 63737009631 Walker B motif; other site 63737009632 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 63737009633 PemK-like protein; Region: PemK; pfam02452 63737009634 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 63737009635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737009636 binding surface 63737009637 TPR motif; other site 63737009638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737009639 binding surface 63737009640 TPR motif; other site 63737009641 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737009642 heat shock protein 90; Provisional; Region: PRK05218 63737009643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009644 ATP binding site [chemical binding]; other site 63737009645 Mg2+ binding site [ion binding]; other site 63737009646 G-X-G motif; other site 63737009647 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737009648 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737009649 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737009650 putative active site [active] 63737009651 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737009652 ligand binding site [chemical binding]; other site 63737009653 flexible hinge region; other site 63737009654 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 63737009655 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 63737009656 putative active site [active] 63737009657 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737009658 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 63737009659 Walker A/P-loop; other site 63737009660 ATP binding site [chemical binding]; other site 63737009661 Q-loop/lid; other site 63737009662 ABC transporter signature motif; other site 63737009663 Walker B; other site 63737009664 D-loop; other site 63737009665 H-loop/switch region; other site 63737009666 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 63737009667 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 63737009668 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737009669 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 63737009670 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 63737009671 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 63737009672 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 63737009673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737009674 binding surface 63737009675 TPR motif; other site 63737009676 Uncharacterized conserved protein [Function unknown]; Region: COG2135 63737009677 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737009678 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 63737009679 putative C-terminal domain interface [polypeptide binding]; other site 63737009680 putative GSH binding site (G-site) [chemical binding]; other site 63737009681 putative dimer interface [polypeptide binding]; other site 63737009682 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737009683 N-terminal domain interface [polypeptide binding]; other site 63737009684 dimer interface [polypeptide binding]; other site 63737009685 substrate binding pocket (H-site) [chemical binding]; other site 63737009686 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 63737009687 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 63737009688 Predicted membrane protein [Function unknown]; Region: COG4244 63737009689 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 63737009690 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 63737009691 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 63737009692 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 63737009693 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 63737009694 Subunit I/III interface [polypeptide binding]; other site 63737009695 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 63737009696 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 63737009697 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 63737009698 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 63737009699 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 63737009700 Predicted membrane protein [Function unknown]; Region: COG4244 63737009701 Predicted membrane protein [Function unknown]; Region: COG4244 63737009702 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 63737009703 CheB methylesterase; Region: CheB_methylest; pfam01339 63737009704 Response regulator receiver domain; Region: Response_reg; pfam00072 63737009705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009706 active site 63737009707 phosphorylation site [posttranslational modification] 63737009708 intermolecular recognition site; other site 63737009709 dimerization interface [polypeptide binding]; other site 63737009710 PAS domain S-box; Region: sensory_box; TIGR00229 63737009711 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009712 putative active site [active] 63737009713 heme pocket [chemical binding]; other site 63737009714 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 63737009715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737009716 dimer interface [polypeptide binding]; other site 63737009717 phosphorylation site [posttranslational modification] 63737009718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009719 ATP binding site [chemical binding]; other site 63737009720 Mg2+ binding site [ion binding]; other site 63737009721 G-X-G motif; other site 63737009722 Response regulator receiver domain; Region: Response_reg; pfam00072 63737009723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009724 active site 63737009725 phosphorylation site [posttranslational modification] 63737009726 intermolecular recognition site; other site 63737009727 dimerization interface [polypeptide binding]; other site 63737009728 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 63737009729 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 63737009730 protein I interface; other site 63737009731 D2 interface; other site 63737009732 protein T interface; other site 63737009733 chlorophyll binding site; other site 63737009734 beta carotene binding site; other site 63737009735 pheophytin binding site; other site 63737009736 manganese-stabilizing polypeptide interface; other site 63737009737 CP43 interface; other site 63737009738 protein L interface; other site 63737009739 oxygen evolving complex binding site; other site 63737009740 bromide binding site; other site 63737009741 quinone binding site; other site 63737009742 Fe binding site [ion binding]; other site 63737009743 core light harvesting interface; other site 63737009744 cytochrome b559 alpha subunit interface; other site 63737009745 cytochrome c-550 interface; other site 63737009746 protein J interface; other site 63737009747 PAS domain S-box; Region: sensory_box; TIGR00229 63737009748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009749 putative active site [active] 63737009750 heme pocket [chemical binding]; other site 63737009751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009752 PAS domain; Region: PAS_9; pfam13426 63737009753 putative active site [active] 63737009754 heme pocket [chemical binding]; other site 63737009755 PAS domain S-box; Region: sensory_box; TIGR00229 63737009756 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737009757 GAF domain; Region: GAF; pfam01590 63737009758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737009759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737009760 dimer interface [polypeptide binding]; other site 63737009761 phosphorylation site [posttranslational modification] 63737009762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009763 ATP binding site [chemical binding]; other site 63737009764 Mg2+ binding site [ion binding]; other site 63737009765 G-X-G motif; other site 63737009766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009767 Response regulator receiver domain; Region: Response_reg; pfam00072 63737009768 active site 63737009769 phosphorylation site [posttranslational modification] 63737009770 intermolecular recognition site; other site 63737009771 dimerization interface [polypeptide binding]; other site 63737009772 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 63737009773 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 63737009774 active site 63737009775 catalytic triad [active] 63737009776 CHAT domain; Region: CHAT; pfam12770 63737009777 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737009778 putative active site [active] 63737009779 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 63737009780 catalytic triad [active] 63737009781 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 63737009782 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 63737009783 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 63737009784 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 63737009785 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737009786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009787 active site 63737009788 phosphorylation site [posttranslational modification] 63737009789 intermolecular recognition site; other site 63737009790 dimerization interface [polypeptide binding]; other site 63737009791 PAS fold; Region: PAS_3; pfam08447 63737009792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 63737009793 putative active site [active] 63737009794 heme pocket [chemical binding]; other site 63737009795 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737009796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737009797 metal binding site [ion binding]; metal-binding site 63737009798 active site 63737009799 I-site; other site 63737009800 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737009801 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 63737009802 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737009803 active site 63737009804 ATP binding site [chemical binding]; other site 63737009805 substrate binding site [chemical binding]; other site 63737009806 activation loop (A-loop); other site 63737009807 AAA ATPase domain; Region: AAA_16; pfam13191 63737009808 Predicted ATPase [General function prediction only]; Region: COG3899 63737009809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737009810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737009811 PAS domain; Region: PAS_9; pfam13426 63737009812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737009813 dimer interface [polypeptide binding]; other site 63737009814 phosphorylation site [posttranslational modification] 63737009815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009816 ATP binding site [chemical binding]; other site 63737009817 Mg2+ binding site [ion binding]; other site 63737009818 G-X-G motif; other site 63737009819 Response regulator receiver domain; Region: Response_reg; pfam00072 63737009820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009821 active site 63737009822 phosphorylation site [posttranslational modification] 63737009823 intermolecular recognition site; other site 63737009824 dimerization interface [polypeptide binding]; other site 63737009825 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 63737009826 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 63737009827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737009828 catalytic residue [active] 63737009829 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 63737009830 RuvA N terminal domain; Region: RuvA_N; pfam01330 63737009831 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 63737009832 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 63737009833 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 63737009834 active site 63737009835 motif I; other site 63737009836 motif II; other site 63737009837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 63737009838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009839 Response regulator receiver domain; Region: Response_reg; pfam00072 63737009840 active site 63737009841 phosphorylation site [posttranslational modification] 63737009842 intermolecular recognition site; other site 63737009843 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737009844 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737009845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009846 PAS fold; Region: PAS_3; pfam08447 63737009847 putative active site [active] 63737009848 heme pocket [chemical binding]; other site 63737009849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009850 PAS fold; Region: PAS_3; pfam08447 63737009851 putative active site [active] 63737009852 heme pocket [chemical binding]; other site 63737009853 PAS domain S-box; Region: sensory_box; TIGR00229 63737009854 PAS fold; Region: PAS_4; pfam08448 63737009855 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 63737009856 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737009857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009858 putative active site [active] 63737009859 heme pocket [chemical binding]; other site 63737009860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009861 putative active site [active] 63737009862 heme pocket [chemical binding]; other site 63737009863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737009864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737009865 dimer interface [polypeptide binding]; other site 63737009866 phosphorylation site [posttranslational modification] 63737009867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009868 ATP binding site [chemical binding]; other site 63737009869 Mg2+ binding site [ion binding]; other site 63737009870 G-X-G motif; other site 63737009871 Response regulator receiver domain; Region: Response_reg; pfam00072 63737009872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009873 active site 63737009874 phosphorylation site [posttranslational modification] 63737009875 intermolecular recognition site; other site 63737009876 dimerization interface [polypeptide binding]; other site 63737009877 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 63737009878 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 63737009879 Tetramer interface [polypeptide binding]; other site 63737009880 active site 63737009881 FMN-binding site [chemical binding]; other site 63737009882 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 63737009883 Clp protease ATP binding subunit; Region: clpC; CHL00095 63737009884 Clp amino terminal domain; Region: Clp_N; pfam02861 63737009885 Clp amino terminal domain; Region: Clp_N; pfam02861 63737009886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009887 Walker A motif; other site 63737009888 ATP binding site [chemical binding]; other site 63737009889 Walker B motif; other site 63737009890 arginine finger; other site 63737009891 UvrB/uvrC motif; Region: UVR; pfam02151 63737009892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737009893 Walker A motif; other site 63737009894 ATP binding site [chemical binding]; other site 63737009895 Walker B motif; other site 63737009896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 63737009897 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737009898 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737009899 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 63737009900 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 63737009901 active site 63737009902 dimer interface [polypeptide binding]; other site 63737009903 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737009904 active site 63737009905 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 63737009906 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 63737009907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737009908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 63737009909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737009910 High-affinity nickel-transport protein; Region: NicO; cl00964 63737009911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009912 PAS fold; Region: PAS_3; pfam08447 63737009913 putative active site [active] 63737009914 heme pocket [chemical binding]; other site 63737009915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737009916 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009917 ATP binding site [chemical binding]; other site 63737009918 Mg2+ binding site [ion binding]; other site 63737009919 G-X-G motif; other site 63737009920 DNA primase; Validated; Region: dnaG; PRK05667 63737009921 CHC2 zinc finger; Region: zf-CHC2; pfam01807 63737009922 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 63737009923 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 63737009924 active site 63737009925 metal binding site [ion binding]; metal-binding site 63737009926 interdomain interaction site; other site 63737009927 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 63737009928 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 63737009929 active site 63737009930 metal binding site [ion binding]; metal-binding site 63737009931 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 63737009932 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 63737009933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737009934 ATP binding site [chemical binding]; other site 63737009935 putative Mg++ binding site [ion binding]; other site 63737009936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737009937 nucleotide binding region [chemical binding]; other site 63737009938 ATP-binding site [chemical binding]; other site 63737009939 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 63737009940 HRDC domain; Region: HRDC; pfam00570 63737009941 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 63737009942 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 63737009943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737009944 S-adenosylmethionine binding site [chemical binding]; other site 63737009945 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737009946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737009947 binding surface 63737009948 TPR motif; other site 63737009949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737009950 PAS domain S-box; Region: sensory_box; TIGR00229 63737009951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009952 putative active site [active] 63737009953 heme pocket [chemical binding]; other site 63737009954 PAS domain S-box; Region: sensory_box; TIGR00229 63737009955 PAS fold; Region: PAS_4; pfam08448 63737009956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009957 putative active site [active] 63737009958 heme pocket [chemical binding]; other site 63737009959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737009960 PAS fold; Region: PAS_3; pfam08447 63737009961 putative active site [active] 63737009962 heme pocket [chemical binding]; other site 63737009963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737009964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737009965 dimer interface [polypeptide binding]; other site 63737009966 phosphorylation site [posttranslational modification] 63737009967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737009968 ATP binding site [chemical binding]; other site 63737009969 Mg2+ binding site [ion binding]; other site 63737009970 G-X-G motif; other site 63737009971 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737009972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737009973 active site 63737009974 phosphorylation site [posttranslational modification] 63737009975 intermolecular recognition site; other site 63737009976 dimerization interface [polypeptide binding]; other site 63737009977 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 63737009978 cyclase homology domain; Region: CHD; cd07302 63737009979 nucleotidyl binding site; other site 63737009980 metal binding site [ion binding]; metal-binding site 63737009981 dimer interface [polypeptide binding]; other site 63737009982 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 63737009983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737009984 ATP binding site [chemical binding]; other site 63737009985 putative Mg++ binding site [ion binding]; other site 63737009986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737009987 nucleotide binding region [chemical binding]; other site 63737009988 ATP-binding site [chemical binding]; other site 63737009989 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 63737009990 Protein of unknown function (DUF790); Region: DUF790; pfam05626 63737009991 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 63737009992 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 63737009993 ATP binding site [chemical binding]; other site 63737009994 Mg++ binding site [ion binding]; other site 63737009995 motif III; other site 63737009996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737009997 nucleotide binding region [chemical binding]; other site 63737009998 ATP-binding site [chemical binding]; other site 63737009999 translation initiation factor IF-3; Region: infC; TIGR00168 63737010000 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 63737010001 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 63737010002 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737010003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737010004 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 63737010005 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737010006 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737010007 DevC protein; Region: devC; TIGR01185 63737010008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737010009 FtsX-like permease family; Region: FtsX; pfam02687 63737010010 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 63737010011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737010012 Walker A/P-loop; other site 63737010013 ATP binding site [chemical binding]; other site 63737010014 Q-loop/lid; other site 63737010015 ABC transporter signature motif; other site 63737010016 Walker B; other site 63737010017 D-loop; other site 63737010018 H-loop/switch region; other site 63737010019 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 63737010020 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 63737010021 putative active site [active] 63737010022 putative metal binding site [ion binding]; other site 63737010023 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 63737010024 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737010025 active site 63737010026 ATP binding site [chemical binding]; other site 63737010027 substrate binding site [chemical binding]; other site 63737010028 activation loop (A-loop); other site 63737010029 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 63737010030 AAA ATPase domain; Region: AAA_16; pfam13191 63737010031 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 63737010032 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 63737010033 Protein of unknown function (DUF815); Region: DUF815; pfam05673 63737010034 Transmembrane proteins 14C; Region: Tmemb_14; cl02346 63737010035 Phosphotransferase enzyme family; Region: APH; pfam01636 63737010036 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 63737010037 active site 63737010038 ATP binding site [chemical binding]; other site 63737010039 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 63737010040 active site 63737010041 ATP binding site [chemical binding]; other site 63737010042 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737010043 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737010044 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737010045 heat shock protein HtpX; Provisional; Region: PRK03982 63737010046 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 63737010047 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737010048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737010049 homodimer interface [polypeptide binding]; other site 63737010050 catalytic residue [active] 63737010051 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 63737010052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737010053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737010054 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 63737010055 ketol-acid reductoisomerase; Provisional; Region: PRK05479 63737010056 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 63737010057 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 63737010058 SET domain; Region: SET; pfam00856 63737010059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 63737010060 EamA-like transporter family; Region: EamA; pfam00892 63737010061 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 63737010062 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 63737010063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 63737010064 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 63737010065 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737010066 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 63737010067 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 63737010068 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 63737010069 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 63737010070 RNase E interface [polypeptide binding]; other site 63737010071 trimer interface [polypeptide binding]; other site 63737010072 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 63737010073 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 63737010074 RNase E interface [polypeptide binding]; other site 63737010075 trimer interface [polypeptide binding]; other site 63737010076 active site 63737010077 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 63737010078 putative nucleic acid binding region [nucleotide binding]; other site 63737010079 G-X-X-G motif; other site 63737010080 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 63737010081 RNA binding site [nucleotide binding]; other site 63737010082 domain interface; other site 63737010083 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 63737010084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737010085 Coenzyme A binding pocket [chemical binding]; other site 63737010086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737010087 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737010088 Uncharacterized conserved protein [Function unknown]; Region: COG4279 63737010089 SWIM zinc finger; Region: SWIM; pfam04434 63737010090 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 63737010091 photosystem II 44 kDa protein; Region: psbC; CHL00035 63737010092 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 63737010093 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 63737010094 D1 interface; other site 63737010095 chlorophyll binding site; other site 63737010096 pheophytin binding site; other site 63737010097 beta carotene binding site; other site 63737010098 cytochrome b559 beta interface; other site 63737010099 quinone binding site; other site 63737010100 cytochrome b559 alpha interface; other site 63737010101 protein J interface; other site 63737010102 protein H interface; other site 63737010103 protein X interface; other site 63737010104 core light harvesting protein interface; other site 63737010105 protein L interface; other site 63737010106 CP43 interface; other site 63737010107 protein T interface; other site 63737010108 Fe binding site [ion binding]; other site 63737010109 protein M interface; other site 63737010110 Mn-stabilizing polypeptide interface; other site 63737010111 bromide binding site; other site 63737010112 cytochrome c-550 interface; other site 63737010113 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 63737010114 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 63737010115 active site 63737010116 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 63737010117 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 63737010118 dimer interface [polypeptide binding]; other site 63737010119 active site 63737010120 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 63737010121 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 63737010122 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 63737010123 NAD(P) binding site [chemical binding]; other site 63737010124 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737010125 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737010126 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 63737010127 Hemerythrin family; Region: Hemerythrin-like; cl15774 63737010128 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737010129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 63737010130 septum formation inhibitor; Reviewed; Region: minC; PRK00513 63737010131 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 63737010132 septum site-determining protein MinD; Region: minD_bact; TIGR01968 63737010133 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 63737010134 Switch I; other site 63737010135 Switch II; other site 63737010136 cell division topological specificity factor MinE; Provisional; Region: PRK13988 63737010137 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 63737010138 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 63737010139 putative active site [active] 63737010140 substrate binding site [chemical binding]; other site 63737010141 putative cosubstrate binding site; other site 63737010142 catalytic site [active] 63737010143 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 63737010144 substrate binding site [chemical binding]; other site 63737010145 Uncharacterized conserved protein [Function unknown]; Region: COG3349 63737010146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737010147 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737010148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737010149 S-adenosylmethionine binding site [chemical binding]; other site 63737010150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 63737010151 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 63737010152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737010153 dimer interface [polypeptide binding]; other site 63737010154 conserved gate region; other site 63737010155 putative PBP binding loops; other site 63737010156 ABC-ATPase subunit interface; other site 63737010157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737010158 Walker A/P-loop; other site 63737010159 ATP binding site [chemical binding]; other site 63737010160 ABC transporter; Region: ABC_tran; pfam00005 63737010161 Q-loop/lid; other site 63737010162 ABC transporter signature motif; other site 63737010163 Walker B; other site 63737010164 D-loop; other site 63737010165 H-loop/switch region; other site 63737010166 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 63737010167 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737010168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010169 active site 63737010170 phosphorylation site [posttranslational modification] 63737010171 intermolecular recognition site; other site 63737010172 dimerization interface [polypeptide binding]; other site 63737010173 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737010174 DNA binding site [nucleotide binding] 63737010175 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 63737010176 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 63737010177 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 63737010178 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 63737010179 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 63737010180 nucleotide binding site [chemical binding]; other site 63737010181 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 63737010182 Uncharacterized conserved protein [Function unknown]; Region: COG2947 63737010183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737010184 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 63737010185 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 63737010186 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 63737010187 MarR family; Region: MarR; pfam01047 63737010188 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 63737010189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737010190 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737010191 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737010192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737010193 putative substrate translocation pore; other site 63737010194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737010195 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 63737010196 putative substrate translocation pore; other site 63737010197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737010198 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737010199 putative active site [active] 63737010200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737010201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 63737010202 binding surface 63737010203 TPR motif; other site 63737010204 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278 63737010205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010206 dimer interface [polypeptide binding]; other site 63737010207 phosphorylation site [posttranslational modification] 63737010208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010209 ATP binding site [chemical binding]; other site 63737010210 Mg2+ binding site [ion binding]; other site 63737010211 G-X-G motif; other site 63737010212 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010214 active site 63737010215 phosphorylation site [posttranslational modification] 63737010216 intermolecular recognition site; other site 63737010217 dimerization interface [polypeptide binding]; other site 63737010218 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737010219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010220 active site 63737010221 phosphorylation site [posttranslational modification] 63737010222 intermolecular recognition site; other site 63737010223 dimerization interface [polypeptide binding]; other site 63737010224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 63737010225 Histidine kinase; Region: HisKA_2; pfam07568 63737010226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010227 ATP binding site [chemical binding]; other site 63737010228 Mg2+ binding site [ion binding]; other site 63737010229 G-X-G motif; other site 63737010230 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737010231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010232 active site 63737010233 phosphorylation site [posttranslational modification] 63737010234 intermolecular recognition site; other site 63737010235 dimerization interface [polypeptide binding]; other site 63737010236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010237 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737010238 putative active site [active] 63737010239 heme pocket [chemical binding]; other site 63737010240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010241 putative active site [active] 63737010242 heme pocket [chemical binding]; other site 63737010243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737010244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737010245 metal binding site [ion binding]; metal-binding site 63737010246 active site 63737010247 I-site; other site 63737010248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737010249 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 63737010250 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 63737010251 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 63737010252 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737010253 TAP-like protein; Region: Abhydrolase_4; pfam08386 63737010254 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 63737010255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737010256 S-adenosylmethionine binding site [chemical binding]; other site 63737010257 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 63737010258 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 63737010259 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737010260 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 63737010261 active site clefts [active] 63737010262 zinc binding site [ion binding]; other site 63737010263 dimer interface [polypeptide binding]; other site 63737010264 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 63737010265 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737010266 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 63737010267 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 63737010268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010269 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010270 active site 63737010271 phosphorylation site [posttranslational modification] 63737010272 intermolecular recognition site; other site 63737010273 dimerization interface [polypeptide binding]; other site 63737010274 PAS domain S-box; Region: sensory_box; TIGR00229 63737010275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010276 putative active site [active] 63737010277 heme pocket [chemical binding]; other site 63737010278 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010279 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737010280 PAS domain S-box; Region: sensory_box; TIGR00229 63737010281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010282 putative active site [active] 63737010283 heme pocket [chemical binding]; other site 63737010284 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737010285 PAS fold; Region: PAS_4; pfam08448 63737010286 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737010287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010288 putative active site [active] 63737010289 heme pocket [chemical binding]; other site 63737010290 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010291 putative active site [active] 63737010292 heme pocket [chemical binding]; other site 63737010293 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010294 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737010295 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010296 dimer interface [polypeptide binding]; other site 63737010297 phosphorylation site [posttranslational modification] 63737010298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010299 ATP binding site [chemical binding]; other site 63737010300 Mg2+ binding site [ion binding]; other site 63737010301 G-X-G motif; other site 63737010302 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010304 active site 63737010305 phosphorylation site [posttranslational modification] 63737010306 intermolecular recognition site; other site 63737010307 dimerization interface [polypeptide binding]; other site 63737010308 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737010309 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 63737010310 metal-binding site 63737010311 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 63737010312 iron-sulfur cluster [ion binding]; other site 63737010313 [2Fe-2S] cluster binding site [ion binding]; other site 63737010314 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 63737010315 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 63737010316 metal ion-dependent adhesion site (MIDAS); other site 63737010317 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 63737010318 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 63737010319 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 63737010320 active site 63737010321 catalytic triad [active] 63737010322 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 63737010323 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 63737010324 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 63737010325 Putative phosphatase (DUF442); Region: DUF442; cl17385 63737010326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 63737010327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737010328 Coenzyme A binding pocket [chemical binding]; other site 63737010329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737010330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737010331 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 63737010332 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 63737010333 putative active site pocket [active] 63737010334 dimerization interface [polypeptide binding]; other site 63737010335 putative catalytic residue [active] 63737010336 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 63737010337 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 63737010338 NADP binding site [chemical binding]; other site 63737010339 homotetramer interface [polypeptide binding]; other site 63737010340 homodimer interface [polypeptide binding]; other site 63737010341 active site 63737010342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737010343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737010344 putative substrate translocation pore; other site 63737010345 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 63737010346 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 63737010347 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 63737010348 active site 63737010349 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 63737010350 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737010351 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737010352 P-loop; other site 63737010353 Magnesium ion binding site [ion binding]; other site 63737010354 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737010355 Magnesium ion binding site [ion binding]; other site 63737010356 Double zinc ribbon; Region: DZR; pfam12773 63737010357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737010358 dimerization interface [polypeptide binding]; other site 63737010359 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737010360 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010361 putative active site [active] 63737010362 heme pocket [chemical binding]; other site 63737010363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010364 dimer interface [polypeptide binding]; other site 63737010365 phosphorylation site [posttranslational modification] 63737010366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010367 ATP binding site [chemical binding]; other site 63737010368 Mg2+ binding site [ion binding]; other site 63737010369 G-X-G motif; other site 63737010370 oxo-acid-lyase/anthranilate synthase; Region: PLN02889 63737010371 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 63737010372 glutamine binding [chemical binding]; other site 63737010373 catalytic triad [active] 63737010374 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 63737010375 chorismate binding enzyme; Region: Chorismate_bind; cl10555 63737010376 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 63737010377 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 63737010378 Walker A/P-loop; other site 63737010379 ATP binding site [chemical binding]; other site 63737010380 Q-loop/lid; other site 63737010381 ABC transporter signature motif; other site 63737010382 Walker B; other site 63737010383 D-loop; other site 63737010384 H-loop/switch region; other site 63737010385 TOBE domain; Region: TOBE; pfam03459 63737010386 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 63737010387 geranylgeranyl reductase; Region: ChlP; TIGR02028 63737010388 FAD binding domain; Region: FAD_binding_4; pfam01565 63737010389 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 63737010390 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 63737010391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737010392 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737010393 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737010394 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737010395 putative active site [active] 63737010396 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737010397 putative active site [active] 63737010398 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 63737010399 active site 63737010400 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737010401 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737010402 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737010403 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737010404 catalytic loop [active] 63737010405 iron binding site [ion binding]; other site 63737010406 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 63737010407 Stage II sporulation protein; Region: SpoIID; pfam08486 63737010408 ParB-like nuclease domain; Region: ParBc; cl02129 63737010409 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 63737010410 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 63737010411 dimerization interface [polypeptide binding]; other site 63737010412 DPS ferroxidase diiron center [ion binding]; other site 63737010413 ion pore; other site 63737010414 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 63737010415 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 63737010416 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 63737010417 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737010418 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 63737010419 anti sigma factor interaction site; other site 63737010420 regulatory phosphorylation site [posttranslational modification]; other site 63737010421 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010423 active site 63737010424 phosphorylation site [posttranslational modification] 63737010425 intermolecular recognition site; other site 63737010426 dimerization interface [polypeptide binding]; other site 63737010427 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 63737010428 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 63737010429 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 63737010430 Peptidase family M48; Region: Peptidase_M48; cl12018 63737010431 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 63737010432 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737010433 putative active site [active] 63737010434 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 63737010435 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 63737010436 TPP-binding site [chemical binding]; other site 63737010437 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 63737010438 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737010439 Cytochrome P450; Region: p450; pfam00067 63737010440 Cytochrome P450; Region: p450; cl12078 63737010441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737010442 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 63737010443 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 63737010444 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737010445 TPR repeat; Region: TPR_11; pfam13414 63737010446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737010447 binding surface 63737010448 TPR motif; other site 63737010449 TPR repeat; Region: TPR_11; pfam13414 63737010450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737010451 binding surface 63737010452 TPR motif; other site 63737010453 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 63737010454 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 63737010455 NADP binding site [chemical binding]; other site 63737010456 active site 63737010457 putative substrate binding site [chemical binding]; other site 63737010458 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737010459 putative active site [active] 63737010460 AAA ATPase domain; Region: AAA_16; pfam13191 63737010461 AAA domain; Region: AAA_22; pfam13401 63737010462 glycine dehydrogenase; Provisional; Region: PRK05367 63737010463 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 63737010464 tetramer interface [polypeptide binding]; other site 63737010465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737010466 catalytic residue [active] 63737010467 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 63737010468 tetramer interface [polypeptide binding]; other site 63737010469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737010470 catalytic residue [active] 63737010471 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 63737010472 lipoyl attachment site [posttranslational modification]; other site 63737010473 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 63737010474 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 63737010475 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 63737010476 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737010477 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737010478 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737010479 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737010480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737010481 binding surface 63737010482 TPR motif; other site 63737010483 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737010484 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737010485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737010486 binding surface 63737010487 TPR motif; other site 63737010488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737010489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737010490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737010491 binding surface 63737010492 TPR motif; other site 63737010493 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 63737010494 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 63737010495 MutS domain I; Region: MutS_I; pfam01624 63737010496 MutS domain II; Region: MutS_II; pfam05188 63737010497 MutS domain III; Region: MutS_III; pfam05192 63737010498 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 63737010499 Walker A/P-loop; other site 63737010500 ATP binding site [chemical binding]; other site 63737010501 Q-loop/lid; other site 63737010502 ABC transporter signature motif; other site 63737010503 Walker B; other site 63737010504 D-loop; other site 63737010505 H-loop/switch region; other site 63737010506 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 63737010507 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737010508 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 63737010509 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737010510 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 63737010511 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 63737010512 putative active site [active] 63737010513 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737010514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737010515 Walker A/P-loop; other site 63737010516 ATP binding site [chemical binding]; other site 63737010517 Q-loop/lid; other site 63737010518 ABC transporter signature motif; other site 63737010519 Walker B; other site 63737010520 D-loop; other site 63737010521 H-loop/switch region; other site 63737010522 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 63737010523 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 63737010524 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737010525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737010526 Walker A/P-loop; other site 63737010527 ATP binding site [chemical binding]; other site 63737010528 Q-loop/lid; other site 63737010529 ABC transporter signature motif; other site 63737010530 Walker B; other site 63737010531 D-loop; other site 63737010532 H-loop/switch region; other site 63737010533 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 63737010534 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 63737010535 putative active site [active] 63737010536 putative metal binding site [ion binding]; other site 63737010537 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 63737010538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010539 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010540 dimer interface [polypeptide binding]; other site 63737010541 phosphorylation site [posttranslational modification] 63737010542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010543 ATP binding site [chemical binding]; other site 63737010544 Mg2+ binding site [ion binding]; other site 63737010545 G-X-G motif; other site 63737010546 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737010547 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737010548 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 63737010549 nudix motif; other site 63737010550 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 63737010551 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 63737010552 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 63737010553 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 63737010554 homodimer interface [polypeptide binding]; other site 63737010555 NADP binding site [chemical binding]; other site 63737010556 substrate binding site [chemical binding]; other site 63737010557 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 63737010558 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 63737010559 substrate binding pocket [chemical binding]; other site 63737010560 chain length determination region; other site 63737010561 substrate-Mg2+ binding site; other site 63737010562 catalytic residues [active] 63737010563 aspartate-rich region 1; other site 63737010564 active site lid residues [active] 63737010565 aspartate-rich region 2; other site 63737010566 Divergent PAP2 family; Region: DUF212; pfam02681 63737010567 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 63737010568 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 63737010569 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 63737010570 active site 63737010571 hydrophilic channel; other site 63737010572 dimerization interface [polypeptide binding]; other site 63737010573 catalytic residues [active] 63737010574 active site lid [active] 63737010575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 63737010576 Uncharacterized conserved protein [Function unknown]; Region: COG2442 63737010577 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737010578 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737010579 active site 63737010580 ATP binding site [chemical binding]; other site 63737010581 substrate binding site [chemical binding]; other site 63737010582 activation loop (A-loop); other site 63737010583 AAA ATPase domain; Region: AAA_16; pfam13191 63737010584 Predicted ATPase [General function prediction only]; Region: COG3899 63737010585 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010586 GAF domain; Region: GAF; pfam01590 63737010587 PAS fold; Region: PAS_4; pfam08448 63737010588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010590 ATP binding site [chemical binding]; other site 63737010591 Mg2+ binding site [ion binding]; other site 63737010592 G-X-G motif; other site 63737010593 Cache domain; Region: Cache_1; pfam02743 63737010594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010596 ATP binding site [chemical binding]; other site 63737010597 Mg2+ binding site [ion binding]; other site 63737010598 G-X-G motif; other site 63737010599 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737010600 putative active site [active] 63737010601 Caspase domain; Region: Peptidase_C14; pfam00656 63737010602 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 63737010603 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 63737010604 putative ligand binding site [chemical binding]; other site 63737010605 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 63737010606 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010607 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737010608 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010609 GAF domain; Region: GAF; pfam01590 63737010610 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010611 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737010612 putative active site [active] 63737010613 heme pocket [chemical binding]; other site 63737010614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010615 dimer interface [polypeptide binding]; other site 63737010616 phosphorylation site [posttranslational modification] 63737010617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010618 ATP binding site [chemical binding]; other site 63737010619 Mg2+ binding site [ion binding]; other site 63737010620 G-X-G motif; other site 63737010621 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010623 active site 63737010624 phosphorylation site [posttranslational modification] 63737010625 intermolecular recognition site; other site 63737010626 dimerization interface [polypeptide binding]; other site 63737010627 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 63737010628 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 63737010629 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737010630 active site 63737010631 metal binding site [ion binding]; metal-binding site 63737010632 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737010633 putative lipid kinase; Reviewed; Region: PRK00861 63737010634 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 63737010635 PEGA domain; Region: PEGA; pfam08308 63737010636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 63737010637 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737010638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010639 active site 63737010640 phosphorylation site [posttranslational modification] 63737010641 intermolecular recognition site; other site 63737010642 dimerization interface [polypeptide binding]; other site 63737010643 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737010644 DNA binding site [nucleotide binding] 63737010645 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737010646 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 63737010647 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737010648 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010649 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737010650 PAS domain S-box; Region: sensory_box; TIGR00229 63737010651 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010652 putative active site [active] 63737010653 heme pocket [chemical binding]; other site 63737010654 PAS domain; Region: PAS; smart00091 63737010655 PAS domain; Region: PAS_9; pfam13426 63737010656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010657 putative active site [active] 63737010658 heme pocket [chemical binding]; other site 63737010659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010661 dimer interface [polypeptide binding]; other site 63737010662 phosphorylation site [posttranslational modification] 63737010663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010664 ATP binding site [chemical binding]; other site 63737010665 G-X-G motif; other site 63737010666 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 63737010667 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 63737010668 domain interfaces; other site 63737010669 active site 63737010670 glycogen synthase; Provisional; Region: glgA; PRK00654 63737010671 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 63737010672 ADP-binding pocket [chemical binding]; other site 63737010673 homodimer interface [polypeptide binding]; other site 63737010674 Acyltransferase family; Region: Acyl_transf_3; pfam01757 63737010675 HEAT-like repeat; Region: HEAT_EZ; pfam13513 63737010676 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 63737010677 HEAT repeats; Region: HEAT_2; pfam13646 63737010678 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 63737010679 HEAT repeats; Region: HEAT_2; pfam13646 63737010680 HEAT repeats; Region: HEAT_2; pfam13646 63737010681 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 63737010682 protein binding surface [polypeptide binding]; other site 63737010683 HEAT repeats; Region: HEAT_2; pfam13646 63737010684 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 63737010685 HEAT repeats; Region: HEAT_2; pfam13646 63737010686 protein binding surface [polypeptide binding]; other site 63737010687 HEAT repeats; Region: HEAT_2; pfam13646 63737010688 Phycobilisome protein; Region: Phycobilisome; cl08227 63737010689 Phycobilisome protein; Region: Phycobilisome; cl08227 63737010690 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 63737010691 CpeS-like protein; Region: CpeS; pfam09367 63737010692 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737010693 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 63737010694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 63737010695 RNA binding surface [nucleotide binding]; other site 63737010696 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 63737010697 active site 63737010698 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737010699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737010700 motif II; other site 63737010701 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502 63737010702 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 63737010703 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737010704 catalytic residues [active] 63737010705 Uncharacterized conserved protein [Function unknown]; Region: COG3391 63737010706 glutaminase; Provisional; Region: PRK00971 63737010707 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 63737010708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737010709 dimerization interface [polypeptide binding]; other site 63737010710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010712 dimer interface [polypeptide binding]; other site 63737010713 phosphorylation site [posttranslational modification] 63737010714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010715 ATP binding site [chemical binding]; other site 63737010716 Mg2+ binding site [ion binding]; other site 63737010717 G-X-G motif; other site 63737010718 photosystem I P700 chlorophyll a apoprotein A1; Provisional; Region: psaA; PRK13200 63737010719 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 63737010720 Transposase IS200 like; Region: Y1_Tnp; cl00848 63737010721 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 63737010722 active site 63737010723 catalytic triad [active] 63737010724 oxyanion hole [active] 63737010725 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 63737010726 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 63737010727 Ligand Binding Site [chemical binding]; other site 63737010728 DNA polymerase III psi subunit; Region: DNA_III_psi; cl11436 63737010729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010731 dimer interface [polypeptide binding]; other site 63737010732 phosphorylation site [posttranslational modification] 63737010733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010734 ATP binding site [chemical binding]; other site 63737010735 Mg2+ binding site [ion binding]; other site 63737010736 G-X-G motif; other site 63737010737 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010739 active site 63737010740 phosphorylation site [posttranslational modification] 63737010741 intermolecular recognition site; other site 63737010742 dimerization interface [polypeptide binding]; other site 63737010743 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 63737010744 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 63737010745 TM-ABC transporter signature motif; other site 63737010746 PsaX family; Region: PsaX; pfam08078 63737010747 lipoyl synthase; Provisional; Region: PRK12928 63737010748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737010749 FeS/SAM binding site; other site 63737010750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737010751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010752 active site 63737010753 phosphorylation site [posttranslational modification] 63737010754 intermolecular recognition site; other site 63737010755 dimerization interface [polypeptide binding]; other site 63737010756 Protein kinase domain; Region: Pkinase; pfam00069 63737010757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737010758 active site 63737010759 ATP binding site [chemical binding]; other site 63737010760 substrate binding site [chemical binding]; other site 63737010761 activation loop (A-loop); other site 63737010762 AAA ATPase domain; Region: AAA_16; pfam13191 63737010763 Predicted ATPase [General function prediction only]; Region: COG3899 63737010764 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737010765 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737010766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010768 dimer interface [polypeptide binding]; other site 63737010769 phosphorylation site [posttranslational modification] 63737010770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010771 ATP binding site [chemical binding]; other site 63737010772 Mg2+ binding site [ion binding]; other site 63737010773 G-X-G motif; other site 63737010774 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737010775 Cytochrome P450; Region: p450; cl12078 63737010776 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 63737010777 substrate binding pocket [chemical binding]; other site 63737010778 substrate-Mg2+ binding site; other site 63737010779 aspartate-rich region 1; other site 63737010780 active site lid residues [active] 63737010781 aspartate-rich region 2; other site 63737010782 Response regulator receiver domain; Region: Response_reg; pfam00072 63737010783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737010784 active site 63737010785 phosphorylation site [posttranslational modification] 63737010786 intermolecular recognition site; other site 63737010787 dimerization interface [polypeptide binding]; other site 63737010788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737010789 dimer interface [polypeptide binding]; other site 63737010790 phosphorylation site [posttranslational modification] 63737010791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010792 ATP binding site [chemical binding]; other site 63737010793 Mg2+ binding site [ion binding]; other site 63737010794 G-X-G motif; other site 63737010795 Uncharacterized conserved protein [Function unknown]; Region: COG3287 63737010796 FIST N domain; Region: FIST; pfam08495 63737010797 FIST C domain; Region: FIST_C; pfam10442 63737010798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737010799 dimer interface [polypeptide binding]; other site 63737010800 phosphorylation site [posttranslational modification] 63737010801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010802 ATP binding site [chemical binding]; other site 63737010803 Mg2+ binding site [ion binding]; other site 63737010804 G-X-G motif; other site 63737010805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737010806 PAS fold; Region: PAS; pfam00989 63737010807 putative active site [active] 63737010808 heme pocket [chemical binding]; other site 63737010809 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737010811 dimer interface [polypeptide binding]; other site 63737010812 phosphorylation site [posttranslational modification] 63737010813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737010814 ATP binding site [chemical binding]; other site 63737010815 Mg2+ binding site [ion binding]; other site 63737010816 G-X-G motif; other site 63737010817 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 63737010818 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737010819 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737010820 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737010821 structural tetrad; other site 63737010822 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 63737010823 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 63737010824 P-loop, Walker A motif; other site 63737010825 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 63737010826 Base recognition motif; other site 63737010827 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 63737010828 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 63737010829 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 63737010830 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 63737010831 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 63737010832 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 63737010833 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 63737010834 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 63737010835 G1 box; other site 63737010836 putative GEF interaction site [polypeptide binding]; other site 63737010837 GTP/Mg2+ binding site [chemical binding]; other site 63737010838 Switch I region; other site 63737010839 G2 box; other site 63737010840 G3 box; other site 63737010841 Switch II region; other site 63737010842 G4 box; other site 63737010843 G5 box; other site 63737010844 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 63737010845 Tic20-like protein; Region: Tic20; pfam09685 63737010846 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 63737010847 dimer interface [polypeptide binding]; other site 63737010848 active site 63737010849 Schiff base residues; other site 63737010850 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 63737010851 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 63737010852 alpha subunit interface [polypeptide binding]; other site 63737010853 TPP binding site [chemical binding]; other site 63737010854 heterodimer interface [polypeptide binding]; other site 63737010855 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 63737010856 protein-export membrane protein SecD; Region: secD; TIGR01129 63737010857 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 63737010858 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 63737010859 Protein export membrane protein; Region: SecD_SecF; pfam02355 63737010860 Uncharacterized protein family (UPF0128); Region: UPF0128; cl00799 63737010861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737010862 Coenzyme A binding pocket [chemical binding]; other site 63737010863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737010864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737010865 dimer interface [polypeptide binding]; other site 63737010866 phosphorylation site [posttranslational modification] 63737010867 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 63737010868 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 63737010869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737010870 S-adenosylmethionine binding site [chemical binding]; other site 63737010871 Tic22-like family; Region: Tic22; pfam04278 63737010872 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 63737010873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737010874 Coenzyme A binding pocket [chemical binding]; other site 63737010875 Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479 63737010876 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737010877 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 63737010878 catalytic site [active] 63737010879 UGMP family protein; Validated; Region: PRK09604 63737010880 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 63737010881 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 63737010882 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 63737010883 photosystem I reaction center protein subunit XI; Provisional; Region: PRK00704 63737010884 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 63737010885 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 63737010886 catalytic site [active] 63737010887 G-X2-G-X-G-K; other site 63737010888 hypothetical protein; Provisional; Region: PRK04323 63737010889 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 63737010890 active site 63737010891 dimer interface [polypeptide binding]; other site 63737010892 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 63737010893 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 63737010894 active site 63737010895 HIGH motif; other site 63737010896 dimer interface [polypeptide binding]; other site 63737010897 KMSKS motif; other site 63737010898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 63737010899 Transglycosylase; Region: Transgly; pfam00912 63737010900 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 63737010901 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737010902 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 63737010903 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737010904 HSP70 interaction site [polypeptide binding]; other site 63737010905 TPR repeat; Region: TPR_11; pfam13414 63737010906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737010907 binding surface 63737010908 TPR motif; other site 63737010909 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 63737010910 Short C-terminal domain; Region: SHOCT; pfam09851 63737010911 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 63737010912 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 63737010913 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 63737010914 Catalytic site [active] 63737010915 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 63737010916 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 63737010917 NodB motif; other site 63737010918 active site 63737010919 catalytic site [active] 63737010920 metal binding site [ion binding]; metal-binding site 63737010921 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 63737010922 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 63737010923 active site 63737010924 dimer interface [polypeptide binding]; other site 63737010925 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 63737010926 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 63737010927 active site 63737010928 FMN binding site [chemical binding]; other site 63737010929 substrate binding site [chemical binding]; other site 63737010930 3Fe-4S cluster binding site [ion binding]; other site 63737010931 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 63737010932 domain interface; other site 63737010933 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 63737010934 Cupin domain; Region: Cupin_2; cl17218 63737010935 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 63737010936 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 63737010937 S17 interaction site [polypeptide binding]; other site 63737010938 S8 interaction site; other site 63737010939 16S rRNA interaction site [nucleotide binding]; other site 63737010940 streptomycin interaction site [chemical binding]; other site 63737010941 23S rRNA interaction site [nucleotide binding]; other site 63737010942 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 63737010943 30S ribosomal protein S7; Validated; Region: PRK05302 63737010944 elongation factor G; Reviewed; Region: PRK00007 63737010945 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 63737010946 G1 box; other site 63737010947 putative GEF interaction site [polypeptide binding]; other site 63737010948 GTP/Mg2+ binding site [chemical binding]; other site 63737010949 Switch I region; other site 63737010950 G2 box; other site 63737010951 G3 box; other site 63737010952 Switch II region; other site 63737010953 G4 box; other site 63737010954 G5 box; other site 63737010955 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 63737010956 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 63737010957 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 63737010958 elongation factor Tu; Region: tufA; CHL00071 63737010959 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 63737010960 G1 box; other site 63737010961 GEF interaction site [polypeptide binding]; other site 63737010962 GTP/Mg2+ binding site [chemical binding]; other site 63737010963 Switch I region; other site 63737010964 G2 box; other site 63737010965 G3 box; other site 63737010966 Switch II region; other site 63737010967 G4 box; other site 63737010968 G5 box; other site 63737010969 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 63737010970 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 63737010971 Antibiotic Binding Site [chemical binding]; other site 63737010972 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 63737010973 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 63737010974 prephenate dehydratase; Provisional; Region: PRK11898 63737010975 Prephenate dehydratase; Region: PDT; pfam00800 63737010976 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 63737010977 putative L-Phe binding site [chemical binding]; other site 63737010978 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 63737010979 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 63737010980 RNA/DNA hybrid binding site [nucleotide binding]; other site 63737010981 active site 63737010982 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 63737010983 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 63737010984 homodimer interface [polypeptide binding]; other site 63737010985 oligonucleotide binding site [chemical binding]; other site 63737010986 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 63737010987 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 63737010988 B12 binding site [chemical binding]; other site 63737010989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011 63737010990 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 63737010991 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737010992 anti sigma factor interaction site; other site 63737010993 regulatory phosphorylation site [posttranslational modification]; other site 63737010994 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737010995 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 63737010996 CAAX protease self-immunity; Region: Abi; pfam02517 63737010997 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 63737010998 RNA binding site [nucleotide binding]; other site 63737010999 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 63737011000 RNA binding site [nucleotide binding]; other site 63737011001 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 63737011002 RNA binding site [nucleotide binding]; other site 63737011003 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011005 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011006 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011007 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011008 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011009 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 63737011010 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 63737011011 Zn2+ binding site [ion binding]; other site 63737011012 Mg2+ binding site [ion binding]; other site 63737011013 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 63737011014 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737011015 FeS/SAM binding site; other site 63737011016 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 63737011017 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 63737011018 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 63737011019 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 63737011020 Walker A/P-loop; other site 63737011021 ATP binding site [chemical binding]; other site 63737011022 Q-loop/lid; other site 63737011023 ABC transporter signature motif; other site 63737011024 Walker B; other site 63737011025 D-loop; other site 63737011026 H-loop/switch region; other site 63737011027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737011028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011029 active site 63737011030 phosphorylation site [posttranslational modification] 63737011031 intermolecular recognition site; other site 63737011032 dimerization interface [polypeptide binding]; other site 63737011033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737011034 DNA binding site [nucleotide binding] 63737011035 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 63737011036 putative GSH binding site [chemical binding]; other site 63737011037 catalytic residues [active] 63737011038 BolA-like protein; Region: BolA; pfam01722 63737011039 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 63737011040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 63737011041 putative acyl-acceptor binding pocket; other site 63737011042 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 63737011043 nucleoside/Zn binding site; other site 63737011044 dimer interface [polypeptide binding]; other site 63737011045 catalytic motif [active] 63737011046 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 63737011047 GSH binding site [chemical binding]; other site 63737011048 catalytic residues [active] 63737011049 Predicted membrane protein [Function unknown]; Region: COG3374 63737011050 Protein of unknown function (DUF981); Region: DUF981; pfam06168 63737011051 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 63737011052 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 63737011053 putative active site [active] 63737011054 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 63737011055 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 63737011056 tRNA; other site 63737011057 putative tRNA binding site [nucleotide binding]; other site 63737011058 putative NADP binding site [chemical binding]; other site 63737011059 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 63737011060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737011061 dimerization interface [polypeptide binding]; other site 63737011062 putative DNA binding site [nucleotide binding]; other site 63737011063 putative Zn2+ binding site [ion binding]; other site 63737011064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860 63737011065 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737011066 putative active site [active] 63737011067 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 63737011068 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 63737011069 Walker A/P-loop; other site 63737011070 ATP binding site [chemical binding]; other site 63737011071 Q-loop/lid; other site 63737011072 ABC transporter signature motif; other site 63737011073 Walker B; other site 63737011074 D-loop; other site 63737011075 H-loop/switch region; other site 63737011076 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 63737011077 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 63737011078 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 63737011079 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 63737011080 TM-ABC transporter signature motif; other site 63737011081 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 63737011082 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 63737011083 active site 63737011084 dimer interface [polypeptide binding]; other site 63737011085 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 63737011086 dimer interface [polypeptide binding]; other site 63737011087 active site 63737011088 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737011089 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737011090 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737011091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737011092 malate dehydrogenase; Reviewed; Region: PRK06223 63737011093 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 63737011094 NAD(P) binding site [chemical binding]; other site 63737011095 dimer interface [polypeptide binding]; other site 63737011096 tetramer (dimer of dimers) interface [polypeptide binding]; other site 63737011097 substrate binding site [chemical binding]; other site 63737011098 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 63737011099 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 63737011100 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 63737011101 DNA binding site [nucleotide binding] 63737011102 catalytic residue [active] 63737011103 H2TH interface [polypeptide binding]; other site 63737011104 putative catalytic residues [active] 63737011105 turnover-facilitating residue; other site 63737011106 intercalation triad [nucleotide binding]; other site 63737011107 8OG recognition residue [nucleotide binding]; other site 63737011108 putative reading head residues; other site 63737011109 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 63737011110 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 63737011111 photosystem I reaction center subunit IV; Provisional; Region: PRK02749 63737011112 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 63737011113 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 63737011114 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 63737011115 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 63737011116 Mg++ binding site [ion binding]; other site 63737011117 putative catalytic motif [active] 63737011118 putative substrate binding site [chemical binding]; other site 63737011119 PAS fold; Region: PAS_4; pfam08448 63737011120 GAF domain; Region: GAF_3; pfam13492 63737011121 GAF domain; Region: GAF_2; pfam13185 63737011122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737011123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737011124 metal binding site [ion binding]; metal-binding site 63737011125 active site 63737011126 I-site; other site 63737011127 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 63737011128 MPT binding site; other site 63737011129 trimer interface [polypeptide binding]; other site 63737011130 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 63737011131 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 63737011132 putative active site [active] 63737011133 dimerization interface [polypeptide binding]; other site 63737011134 putative tRNAtyr binding site [nucleotide binding]; other site 63737011135 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 63737011136 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737011137 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 63737011138 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 63737011139 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 63737011140 active site 63737011141 HIGH motif; other site 63737011142 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 63737011143 KMSKS motif; other site 63737011144 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 63737011145 tRNA binding surface [nucleotide binding]; other site 63737011146 anticodon binding site; other site 63737011147 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 63737011148 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 63737011149 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 63737011150 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 63737011151 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 63737011152 active site 63737011153 (T/H)XGH motif; other site 63737011154 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 63737011155 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 63737011156 active site 63737011157 SAM binding site [chemical binding]; other site 63737011158 homodimer interface [polypeptide binding]; other site 63737011159 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 63737011160 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 63737011161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737011162 FeS/SAM binding site; other site 63737011163 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 63737011164 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 63737011165 GIY-YIG motif/motif A; other site 63737011166 active site 63737011167 catalytic site [active] 63737011168 putative DNA binding site [nucleotide binding]; other site 63737011169 metal binding site [ion binding]; metal-binding site 63737011170 UvrB/uvrC motif; Region: UVR; pfam02151 63737011171 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 63737011172 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 63737011173 Response regulator receiver domain; Region: Response_reg; pfam00072 63737011174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011175 active site 63737011176 phosphorylation site [posttranslational modification] 63737011177 intermolecular recognition site; other site 63737011178 dimerization interface [polypeptide binding]; other site 63737011179 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 63737011180 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 63737011181 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737011182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737011183 homodimer interface [polypeptide binding]; other site 63737011184 catalytic residue [active] 63737011185 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 63737011186 catalytic residues [active] 63737011187 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 63737011188 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 63737011189 Protein of unknown function (DUF721); Region: DUF721; cl02324 63737011190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 63737011191 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 63737011192 substrate binding site [chemical binding]; other site 63737011193 oxyanion hole (OAH) forming residues; other site 63737011194 trimer interface [polypeptide binding]; other site 63737011195 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737011196 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 63737011197 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737011198 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 63737011199 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 63737011200 dimer interface [polypeptide binding]; other site 63737011201 tetramer interface [polypeptide binding]; other site 63737011202 PYR/PP interface [polypeptide binding]; other site 63737011203 TPP binding site [chemical binding]; other site 63737011204 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 63737011205 TPP-binding site; other site 63737011206 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 63737011207 homooctamer interface [polypeptide binding]; other site 63737011208 active site 63737011209 Response regulator receiver domain; Region: Response_reg; pfam00072 63737011210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011211 active site 63737011212 phosphorylation site [posttranslational modification] 63737011213 intermolecular recognition site; other site 63737011214 dimerization interface [polypeptide binding]; other site 63737011215 PAS domain; Region: PAS; smart00091 63737011216 PAS domain S-box; Region: sensory_box; TIGR00229 63737011217 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737011218 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737011219 metal binding site [ion binding]; metal-binding site 63737011220 active site 63737011221 I-site; other site 63737011222 maltose O-acetyltransferase; Provisional; Region: PRK10092 63737011223 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 63737011224 active site 63737011225 substrate binding site [chemical binding]; other site 63737011226 trimer interface [polypeptide binding]; other site 63737011227 CoA binding site [chemical binding]; other site 63737011228 Calcium binding; Region: Calci_bind_CcbP; pfam11535 63737011229 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737011230 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 63737011231 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 63737011232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737011233 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 63737011234 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 63737011235 thiS-thiF/thiG interaction site; other site 63737011236 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 63737011237 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 63737011238 thiamine phosphate binding site [chemical binding]; other site 63737011239 active site 63737011240 pyrophosphate binding site [ion binding]; other site 63737011241 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 63737011242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737011243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737011244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737011245 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 63737011246 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737011247 Di-iron ligands [ion binding]; other site 63737011248 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 63737011249 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 63737011250 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 63737011251 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 63737011252 FMN binding site [chemical binding]; other site 63737011253 active site 63737011254 catalytic residues [active] 63737011255 substrate binding site [chemical binding]; other site 63737011256 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737011257 putative active site [active] 63737011258 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 63737011259 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 63737011260 hexamer interface [polypeptide binding]; other site 63737011261 ligand binding site [chemical binding]; other site 63737011262 putative active site [active] 63737011263 NAD(P) binding site [chemical binding]; other site 63737011264 light-harvesting-like protein 3; Provisional; Region: PLN00014 63737011265 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737011266 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737011267 structural tetrad; other site 63737011268 Predicted permeases [General function prediction only]; Region: COG0701 63737011269 TIGR03943 family protein; Region: TIGR03943 63737011270 Bacterial Ig-like domain; Region: Big_5; pfam13205 63737011271 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 63737011272 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 63737011273 Moco binding site; other site 63737011274 metal coordination site [ion binding]; other site 63737011275 dimerization interface [polypeptide binding]; other site 63737011276 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 63737011277 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 63737011278 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737011279 catalytic residue [active] 63737011280 hypothetical protein; Provisional; Region: PRK11281 63737011281 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 63737011282 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 63737011283 active site 63737011284 substrate binding site [chemical binding]; other site 63737011285 catalytic site [active] 63737011286 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 63737011287 arginine-tRNA ligase; Region: PLN02286 63737011288 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 63737011289 active site 63737011290 HIGH motif; other site 63737011291 KMSK motif region; other site 63737011292 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 63737011293 tRNA binding surface [nucleotide binding]; other site 63737011294 anticodon binding site; other site 63737011295 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 63737011296 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 63737011297 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 63737011298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 63737011299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 63737011300 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 63737011301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 63737011302 DALR anticodon binding domain; Region: DALR_1; pfam05746 63737011303 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 63737011304 putative glycosyl transferase; Provisional; Region: PRK10307 63737011305 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 63737011306 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 63737011307 E3 interaction surface; other site 63737011308 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737011309 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737011310 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 63737011311 Protein export membrane protein; Region: SecD_SecF; cl14618 63737011312 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 63737011313 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 63737011314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737011315 Soluble P-type ATPase [General function prediction only]; Region: COG4087 63737011316 Immunity protein Imm1; Region: Imm1; pfam14430 63737011317 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 63737011318 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 63737011319 DNA binding residues [nucleotide binding] 63737011320 dimer interface [polypeptide binding]; other site 63737011321 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 63737011322 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 63737011323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 63737011324 dimerization interface [polypeptide binding]; other site 63737011325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 63737011326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 63737011327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 63737011328 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737011329 putative active site [active] 63737011330 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 63737011331 AMP binding site [chemical binding]; other site 63737011332 metal binding site [ion binding]; metal-binding site 63737011333 active site 63737011334 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 63737011335 putative active site [active] 63737011336 transaldolase; Provisional; Region: PRK03903 63737011337 catalytic residue [active] 63737011338 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 63737011339 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 63737011340 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 63737011341 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 63737011342 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737011343 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 63737011344 S-layer homology domain; Region: SLH; pfam00395 63737011345 S-layer homology domain; Region: SLH; pfam00395 63737011346 S-layer homology domain; Region: SLH; pfam00395 63737011347 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 63737011348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737011349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737011350 dimer interface [polypeptide binding]; other site 63737011351 phosphorylation site [posttranslational modification] 63737011352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737011353 ATP binding site [chemical binding]; other site 63737011354 Mg2+ binding site [ion binding]; other site 63737011355 G-X-G motif; other site 63737011356 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 63737011357 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 63737011358 Predicted transcriptional regulators [Transcription]; Region: COG1695 63737011359 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 63737011360 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 63737011361 seryl-tRNA synthetase; Provisional; Region: PRK05431 63737011362 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 63737011363 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 63737011364 dimer interface [polypeptide binding]; other site 63737011365 active site 63737011366 motif 1; other site 63737011367 motif 2; other site 63737011368 motif 3; other site 63737011369 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 63737011370 active site 63737011371 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 63737011372 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 63737011373 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 63737011374 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 63737011375 minor groove reading motif; other site 63737011376 helix-hairpin-helix signature motif; other site 63737011377 substrate binding pocket [chemical binding]; other site 63737011378 active site 63737011379 ribosomal protein S14; Region: rps14; CHL00074 63737011380 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 63737011381 Protein of unknown function (DUF1308); Region: DUF1308; pfam07000 63737011382 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 63737011383 Protein of unknown function (DUF433); Region: DUF433; pfam04255 63737011384 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 63737011385 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 63737011386 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 63737011387 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 63737011388 active site 63737011389 catalytic residues [active] 63737011390 metal binding site [ion binding]; metal-binding site 63737011391 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 63737011392 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 63737011393 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737011394 Coenzyme A binding pocket [chemical binding]; other site 63737011395 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 63737011396 DHH family; Region: DHH; pfam01368 63737011397 DHHA1 domain; Region: DHHA1; pfam02272 63737011398 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737011399 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011400 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011401 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011402 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 63737011403 Cadmium resistance transporter; Region: Cad; pfam03596 63737011404 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737011405 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737011406 ligand binding site [chemical binding]; other site 63737011407 flexible hinge region; other site 63737011408 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 63737011409 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737011410 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 63737011411 catalytic triad [active] 63737011412 Right handed beta helix region; Region: Beta_helix; pfam13229 63737011413 S-layer homology domain; Region: SLH; pfam00395 63737011414 S-layer homology domain; Region: SLH; pfam00395 63737011415 S-layer homology domain; Region: SLH; pfam00395 63737011416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737011417 TPR motif; other site 63737011418 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737011419 binding surface 63737011420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737011421 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 63737011422 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 63737011423 ThiS interaction site; other site 63737011424 putative active site [active] 63737011425 tetramer interface [polypeptide binding]; other site 63737011426 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737011427 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737011428 catalytic loop [active] 63737011429 iron binding site [ion binding]; other site 63737011430 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 63737011431 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 63737011432 active site 63737011433 catalytic residues [active] 63737011434 metal binding site [ion binding]; metal-binding site 63737011435 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 63737011436 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 63737011437 Predicted membrane protein [Function unknown]; Region: COG1950 63737011438 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737011439 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737011440 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737011441 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737011442 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737011443 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737011444 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737011445 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737011446 Protein kinase domain; Region: Pkinase; pfam00069 63737011447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737011448 active site 63737011449 ATP binding site [chemical binding]; other site 63737011450 substrate binding site [chemical binding]; other site 63737011451 activation loop (A-loop); other site 63737011452 AAA ATPase domain; Region: AAA_16; pfam13191 63737011453 Predicted ATPase [General function prediction only]; Region: COG3899 63737011454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737011455 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737011456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737011457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737011458 ATP binding site [chemical binding]; other site 63737011459 Mg2+ binding site [ion binding]; other site 63737011460 G-X-G motif; other site 63737011461 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 63737011462 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 63737011463 NAD binding site [chemical binding]; other site 63737011464 ATP-grasp domain; Region: ATP-grasp; pfam02222 63737011465 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011466 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011467 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011468 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 63737011469 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 63737011470 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 63737011471 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 63737011472 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 63737011473 MoaE homodimer interface [polypeptide binding]; other site 63737011474 MoaD interaction [polypeptide binding]; other site 63737011475 active site residues [active] 63737011476 KTSC domain; Region: KTSC; pfam13619 63737011477 2-isopropylmalate synthase; Validated; Region: PRK00915 63737011478 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 63737011479 active site 63737011480 catalytic residues [active] 63737011481 metal binding site [ion binding]; metal-binding site 63737011482 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 63737011483 Transcriptional regulators [Transcription]; Region: GntR; COG1802 63737011484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 63737011485 DNA-binding site [nucleotide binding]; DNA binding site 63737011486 FCD domain; Region: FCD; pfam07729 63737011487 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 63737011488 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 63737011489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737011490 active site 63737011491 ATP binding site [chemical binding]; other site 63737011492 substrate binding site [chemical binding]; other site 63737011493 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737011494 activation loop (A-loop); other site 63737011495 AAA ATPase domain; Region: AAA_16; pfam13191 63737011496 Predicted ATPase [General function prediction only]; Region: COG3899 63737011497 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737011498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737011499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737011500 ATP binding site [chemical binding]; other site 63737011501 Mg2+ binding site [ion binding]; other site 63737011502 G-X-G motif; other site 63737011503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 63737011504 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 63737011505 Uncharacterized conserved protein [Function unknown]; Region: COG3791 63737011506 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 63737011507 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 63737011508 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 63737011509 homodimer interface [polypeptide binding]; other site 63737011510 Walker A motif; other site 63737011511 ATP binding site [chemical binding]; other site 63737011512 hydroxycobalamin binding site [chemical binding]; other site 63737011513 Walker B motif; other site 63737011514 RNA polymerase sigma factor; Validated; Region: PRK05949 63737011515 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737011516 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737011517 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737011518 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737011519 DNA binding residues [nucleotide binding] 63737011520 HAS barrel domain; Region: HAS-barrel; pfam09378 63737011521 HerA helicase [Replication, recombination, and repair]; Region: COG0433 63737011522 Domain of unknown function DUF87; Region: DUF87; pfam01935 63737011523 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737011524 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 63737011525 C-terminal domain interface [polypeptide binding]; other site 63737011526 GSH binding site (G-site) [chemical binding]; other site 63737011527 dimer interface [polypeptide binding]; other site 63737011528 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 63737011529 N-terminal domain interface [polypeptide binding]; other site 63737011530 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 63737011531 Fasciclin domain; Region: Fasciclin; pfam02469 63737011532 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 63737011533 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 63737011534 NodB motif; other site 63737011535 active site 63737011536 catalytic site [active] 63737011537 metal binding site [ion binding]; metal-binding site 63737011538 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 63737011539 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737011540 inhibitor-cofactor binding pocket; inhibition site 63737011541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737011542 catalytic residue [active] 63737011543 ChaB; Region: ChaB; cl01887 63737011544 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 63737011545 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 63737011546 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 63737011547 metal binding site [ion binding]; metal-binding site 63737011548 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737011549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737011550 putative substrate translocation pore; other site 63737011551 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 63737011552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737011553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011554 active site 63737011555 phosphorylation site [posttranslational modification] 63737011556 intermolecular recognition site; other site 63737011557 dimerization interface [polypeptide binding]; other site 63737011558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737011559 DNA binding site [nucleotide binding] 63737011560 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 63737011561 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737011562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737011563 motif II; other site 63737011564 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 63737011565 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 63737011566 dimer interface [polypeptide binding]; other site 63737011567 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 63737011568 active site 63737011569 Fe binding site [ion binding]; other site 63737011570 classical (c) SDRs; Region: SDR_c; cd05233 63737011571 NAD(P) binding site [chemical binding]; other site 63737011572 active site 63737011573 LabA_like proteins; Region: LabA_like; cd06167 63737011574 putative metal binding site [ion binding]; other site 63737011575 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258 63737011576 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 63737011577 Walker A/P-loop; other site 63737011578 ATP binding site [chemical binding]; other site 63737011579 Q-loop/lid; other site 63737011580 ABC transporter signature motif; other site 63737011581 Walker B; other site 63737011582 D-loop; other site 63737011583 H-loop/switch region; other site 63737011584 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14260 63737011585 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 63737011586 Walker A/P-loop; other site 63737011587 ATP binding site [chemical binding]; other site 63737011588 Q-loop/lid; other site 63737011589 ABC transporter signature motif; other site 63737011590 Walker B; other site 63737011591 D-loop; other site 63737011592 H-loop/switch region; other site 63737011593 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 63737011594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737011595 dimer interface [polypeptide binding]; other site 63737011596 conserved gate region; other site 63737011597 putative PBP binding loops; other site 63737011598 ABC-ATPase subunit interface; other site 63737011599 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 63737011600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737011601 dimer interface [polypeptide binding]; other site 63737011602 conserved gate region; other site 63737011603 putative PBP binding loops; other site 63737011604 ABC-ATPase subunit interface; other site 63737011605 PBP superfamily domain; Region: PBP_like_2; cl17296 63737011606 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737011607 putative active site [active] 63737011608 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 63737011609 RDD family; Region: RDD; pfam06271 63737011610 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 63737011611 DNA polymerase III subunit delta; Validated; Region: PRK07452 63737011612 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 63737011613 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 63737011614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737011615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737011616 DNA binding residues [nucleotide binding] 63737011617 recombination protein RecR; Reviewed; Region: recR; PRK00076 63737011618 RecR protein; Region: RecR; pfam02132 63737011619 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 63737011620 putative active site [active] 63737011621 putative metal-binding site [ion binding]; other site 63737011622 tetramer interface [polypeptide binding]; other site 63737011623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737011624 binding surface 63737011625 TPR motif; other site 63737011626 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 63737011627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737011628 binding surface 63737011629 TPR motif; other site 63737011630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737011631 binding surface 63737011632 TPR motif; other site 63737011633 CHAT domain; Region: CHAT; cl17868 63737011634 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 63737011635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737011636 Walker A motif; other site 63737011637 ATP binding site [chemical binding]; other site 63737011638 Walker B motif; other site 63737011639 arginine finger; other site 63737011640 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 63737011641 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 63737011642 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 63737011643 DXD motif; other site 63737011644 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; cl01951 63737011645 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 63737011646 RloB-like protein; Region: RloB; pfam13707 63737011647 AAA domain; Region: AAA_21; pfam13304 63737011648 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737011649 ABC transporter signature motif; other site 63737011650 Walker B; other site 63737011651 D-loop; other site 63737011652 H-loop/switch region; other site 63737011653 Predicted GTPase [General function prediction only]; Region: COG3596 63737011654 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737011655 G1 box; other site 63737011656 GTP/Mg2+ binding site [chemical binding]; other site 63737011657 G2 box; other site 63737011658 Switch I region; other site 63737011659 G3 box; other site 63737011660 Switch II region; other site 63737011661 G4 box; other site 63737011662 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737011663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737011664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737011665 dimer interface [polypeptide binding]; other site 63737011666 phosphorylation site [posttranslational modification] 63737011667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737011668 ATP binding site [chemical binding]; other site 63737011669 Mg2+ binding site [ion binding]; other site 63737011670 G-X-G motif; other site 63737011671 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737011672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011673 active site 63737011674 phosphorylation site [posttranslational modification] 63737011675 intermolecular recognition site; other site 63737011676 dimerization interface [polypeptide binding]; other site 63737011677 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 63737011678 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 63737011679 dimer interface [polypeptide binding]; other site 63737011680 PYR/PP interface [polypeptide binding]; other site 63737011681 TPP binding site [chemical binding]; other site 63737011682 substrate binding site [chemical binding]; other site 63737011683 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 63737011684 Domain of unknown function; Region: EKR; pfam10371 63737011685 4Fe-4S binding domain; Region: Fer4_6; pfam12837 63737011686 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 63737011687 TPP-binding site [chemical binding]; other site 63737011688 dimer interface [polypeptide binding]; other site 63737011689 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737011690 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 63737011691 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737011692 M28 Zn-Peptidases; Region: M28_like_1; cd05640 63737011693 Peptidase family M28; Region: Peptidase_M28; pfam04389 63737011694 metal binding site [ion binding]; metal-binding site 63737011695 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 63737011696 Uncharacterized conserved protein [Function unknown]; Region: COG2836 63737011697 Predicted membrane protein [Function unknown]; Region: COG2717 63737011698 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 63737011699 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 63737011700 NAD binding site [chemical binding]; other site 63737011701 homodimer interface [polypeptide binding]; other site 63737011702 active site 63737011703 substrate binding site [chemical binding]; other site 63737011704 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737011705 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737011706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737011707 Walker A/P-loop; other site 63737011708 ATP binding site [chemical binding]; other site 63737011709 Q-loop/lid; other site 63737011710 ABC transporter signature motif; other site 63737011711 Walker B; other site 63737011712 D-loop; other site 63737011713 H-loop/switch region; other site 63737011714 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 63737011715 putative catalytic site [active] 63737011716 putative metal binding site [ion binding]; other site 63737011717 putative phosphate binding site [ion binding]; other site 63737011718 Endonuclease I; Region: Endonuclease_1; cl01003 63737011719 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 63737011720 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737011721 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737011722 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737011723 DevC protein; Region: devC; TIGR01185 63737011724 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737011725 FtsX-like permease family; Region: FtsX; pfam02687 63737011726 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 63737011727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737011728 Walker A/P-loop; other site 63737011729 ATP binding site [chemical binding]; other site 63737011730 Q-loop/lid; other site 63737011731 ABC transporter signature motif; other site 63737011732 Walker B; other site 63737011733 D-loop; other site 63737011734 H-loop/switch region; other site 63737011735 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 63737011736 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737011737 Late competence development protein ComFB; Region: ComFB; pfam10719 63737011738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 63737011739 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 63737011740 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 63737011741 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737011742 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737011743 DNA binding residues [nucleotide binding] 63737011744 Putative zinc-finger; Region: zf-HC2; pfam13490 63737011745 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 63737011746 putative active site pocket [active] 63737011747 dimerization interface [polypeptide binding]; other site 63737011748 putative catalytic residue [active] 63737011749 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 63737011750 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 63737011751 HIGH motif; other site 63737011752 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 63737011753 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 63737011754 active site 63737011755 KMSKS motif; other site 63737011756 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 63737011757 tRNA binding surface [nucleotide binding]; other site 63737011758 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 63737011759 homodimer interface [polypeptide binding]; other site 63737011760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737011761 catalytic residue [active] 63737011762 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 63737011763 Uncharacterized conserved protein [Function unknown]; Region: COG1430 63737011764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737011765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011766 active site 63737011767 phosphorylation site [posttranslational modification] 63737011768 intermolecular recognition site; other site 63737011769 dimerization interface [polypeptide binding]; other site 63737011770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737011771 DNA binding site [nucleotide binding] 63737011772 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 63737011773 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 63737011774 Ycf39; Provisional; Region: ycf39; CHL00194 63737011775 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 63737011776 NAD(P) binding site [chemical binding]; other site 63737011777 putative active site [active] 63737011778 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 63737011779 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 63737011780 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 63737011781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737011782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011783 active site 63737011784 phosphorylation site [posttranslational modification] 63737011785 intermolecular recognition site; other site 63737011786 dimerization interface [polypeptide binding]; other site 63737011787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737011788 DNA binding site [nucleotide binding] 63737011789 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 63737011790 active site residue [active] 63737011791 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 63737011792 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 63737011793 catalytic site [active] 63737011794 putative active site [active] 63737011795 putative substrate binding site [chemical binding]; other site 63737011796 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 63737011797 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 63737011798 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 63737011799 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 63737011800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737011801 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737011802 S-adenosylmethionine binding site [chemical binding]; other site 63737011803 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 63737011804 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 63737011805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737011806 catalytic residue [active] 63737011807 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 63737011808 putative rRNA binding site [nucleotide binding]; other site 63737011809 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 63737011810 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 63737011811 active site clefts [active] 63737011812 zinc binding site [ion binding]; other site 63737011813 dimer interface [polypeptide binding]; other site 63737011814 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 63737011815 active site 63737011816 ribulose/triose binding site [chemical binding]; other site 63737011817 phosphate binding site [ion binding]; other site 63737011818 substrate (anthranilate) binding pocket [chemical binding]; other site 63737011819 product (indole) binding pocket [chemical binding]; other site 63737011820 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 63737011821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737011822 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737011823 Uncharacterized conserved protein [Function unknown]; Region: COG4715 63737011824 SWIM zinc finger; Region: SWIM; pfam04434 63737011825 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 63737011826 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737011827 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737011828 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737011829 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737011830 phosphopeptide binding site; other site 63737011831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737011832 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737011833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737011834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737011835 metal binding site [ion binding]; metal-binding site 63737011836 active site 63737011837 I-site; other site 63737011838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737011839 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 63737011840 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 63737011841 active site 63737011842 Zn binding site [ion binding]; other site 63737011843 tellurite resistance protein terB; Region: terB; cd07176 63737011844 putative metal binding site [ion binding]; other site 63737011845 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 63737011846 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 63737011847 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 63737011848 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 63737011849 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 63737011850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 63737011851 Coenzyme A binding pocket [chemical binding]; other site 63737011852 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 63737011853 Fasciclin domain; Region: Fasciclin; pfam02469 63737011854 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 63737011855 Glucose inhibited division protein A; Region: GIDA; pfam01134 63737011856 TPR repeat; Region: TPR_11; pfam13414 63737011857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737011858 binding surface 63737011859 TPR motif; other site 63737011860 TPR repeat; Region: TPR_11; pfam13414 63737011861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737011862 binding surface 63737011863 TPR motif; other site 63737011864 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737011865 TPR repeat; Region: TPR_11; pfam13414 63737011866 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 63737011867 oligomerization interface [polypeptide binding]; other site 63737011868 active site 63737011869 metal binding site [ion binding]; metal-binding site 63737011870 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 63737011871 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 63737011872 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 63737011873 homodimer interface [polypeptide binding]; other site 63737011874 active site 63737011875 heterodimer interface [polypeptide binding]; other site 63737011876 catalytic residue [active] 63737011877 metal binding site [ion binding]; metal-binding site 63737011878 RbcX protein; Region: RcbX; pfam02341 63737011879 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 63737011880 multimerization interface [polypeptide binding]; other site 63737011881 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 63737011882 active site 63737011883 catalytic triad [active] 63737011884 oxyanion hole [active] 63737011885 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 63737011886 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 63737011887 putative active site [active] 63737011888 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 63737011889 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 63737011890 putative multimerization interface [polypeptide binding]; other site 63737011891 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 63737011892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011893 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011894 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011895 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737011896 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011897 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011898 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 63737011899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737011900 putative active site [active] 63737011901 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737011902 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011903 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737011904 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737011905 S-layer homology domain; Region: SLH; pfam00395 63737011906 S-layer homology domain; Region: SLH; pfam00395 63737011907 S-layer homology domain; Region: SLH; pfam00395 63737011908 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 63737011909 Fasciclin domain; Region: Fasciclin; pfam02469 63737011910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737011911 PAS domain; Region: PAS_9; pfam13426 63737011912 putative active site [active] 63737011913 heme pocket [chemical binding]; other site 63737011914 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737011915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737011916 putative active site [active] 63737011917 heme pocket [chemical binding]; other site 63737011918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737011919 putative active site [active] 63737011920 heme pocket [chemical binding]; other site 63737011921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737011922 PAS fold; Region: PAS_3; pfam08447 63737011923 putative active site [active] 63737011924 heme pocket [chemical binding]; other site 63737011925 PAS domain S-box; Region: sensory_box; TIGR00229 63737011926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737011927 putative active site [active] 63737011928 heme pocket [chemical binding]; other site 63737011929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737011930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737011931 dimer interface [polypeptide binding]; other site 63737011932 phosphorylation site [posttranslational modification] 63737011933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737011934 ATP binding site [chemical binding]; other site 63737011935 Mg2+ binding site [ion binding]; other site 63737011936 G-X-G motif; other site 63737011937 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737011938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011939 active site 63737011940 phosphorylation site [posttranslational modification] 63737011941 intermolecular recognition site; other site 63737011942 dimerization interface [polypeptide binding]; other site 63737011943 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 63737011944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737011945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737011946 active site 63737011947 phosphorylation site [posttranslational modification] 63737011948 intermolecular recognition site; other site 63737011949 dimerization interface [polypeptide binding]; other site 63737011950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737011951 DNA binding site [nucleotide binding] 63737011952 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737011953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737011954 dimer interface [polypeptide binding]; other site 63737011955 phosphorylation site [posttranslational modification] 63737011956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737011957 ATP binding site [chemical binding]; other site 63737011958 Mg2+ binding site [ion binding]; other site 63737011959 G-X-G motif; other site 63737011960 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 63737011961 PhoU domain; Region: PhoU; pfam01895 63737011962 PhoU domain; Region: PhoU; pfam01895 63737011963 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 63737011964 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 63737011965 Ligand binding site; other site 63737011966 Putative Catalytic site; other site 63737011967 DXD motif; other site 63737011968 Predicted membrane protein [Function unknown]; Region: COG2246 63737011969 GtrA-like protein; Region: GtrA; pfam04138 63737011970 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737011971 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 63737011972 putative switch regulator; other site 63737011973 non-specific DNA interactions [nucleotide binding]; other site 63737011974 DNA binding site [nucleotide binding] 63737011975 sequence specific DNA binding site [nucleotide binding]; other site 63737011976 putative cAMP binding site [chemical binding]; other site 63737011977 S-layer homology domain; Region: SLH; pfam00395 63737011978 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737011979 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 63737011980 carotene isomerase; Region: carot_isom; TIGR02730 63737011981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737011982 hydroxyglutarate oxidase; Provisional; Region: PRK11728 63737011983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737011984 active site 63737011985 YGGT family; Region: YGGT; pfam02325 63737011986 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 63737011987 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737011988 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737011989 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 63737011990 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 63737011991 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 63737011992 shikimate binding site; other site 63737011993 NAD(P) binding site [chemical binding]; other site 63737011994 hydrolase, alpha/beta fold family protein; Region: PLN02824 63737011995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 63737011996 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 63737011997 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 63737011998 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 63737011999 NodB motif; other site 63737012000 active site 63737012001 catalytic site [active] 63737012002 metal binding site [ion binding]; metal-binding site 63737012003 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 63737012004 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 63737012005 putative substrate binding site [chemical binding]; other site 63737012006 putative ATP binding site [chemical binding]; other site 63737012007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737012008 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737012009 DNA binding residues [nucleotide binding] 63737012010 dimerization interface [polypeptide binding]; other site 63737012011 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737012012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 63737012013 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 63737012014 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 63737012015 NAD binding site [chemical binding]; other site 63737012016 substrate binding site [chemical binding]; other site 63737012017 homodimer interface [polypeptide binding]; other site 63737012018 active site 63737012019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737012020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737012021 active site 63737012022 ATP binding site [chemical binding]; other site 63737012023 substrate binding site [chemical binding]; other site 63737012024 activation loop (A-loop); other site 63737012025 methionine sulfoxide reductase A; Provisional; Region: PRK00058 63737012026 Predicted membrane protein [Function unknown]; Region: COG2149 63737012027 proton extrusion protein PcxA; Provisional; Region: PRK02507 63737012028 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 63737012029 MltA specific insert domain; Region: MltA; pfam03562 63737012030 3D domain; Region: 3D; pfam06725 63737012031 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 63737012032 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737012033 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737012034 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737012035 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 63737012036 PBP superfamily domain; Region: PBP_like_2; cl17296 63737012037 Domain of unknown function DUF87; Region: DUF87; pfam01935 63737012038 AAA-like domain; Region: AAA_10; pfam12846 63737012039 membrane protein; Provisional; Region: PRK14419 63737012040 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 63737012041 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 63737012042 Permease; Region: Permease; cl00510 63737012043 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 63737012044 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 63737012045 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 63737012046 tandem repeat interface [polypeptide binding]; other site 63737012047 oligomer interface [polypeptide binding]; other site 63737012048 active site residues [active] 63737012049 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 63737012050 homotrimer interaction site [polypeptide binding]; other site 63737012051 active site 63737012052 Opioid growth factor receptor (OGFr) conserved region; Region: OGFr_N; pfam04664 63737012053 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 63737012054 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 63737012055 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737012056 dimerization interface [polypeptide binding]; other site 63737012057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737012058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737012059 metal binding site [ion binding]; metal-binding site 63737012060 active site 63737012061 I-site; other site 63737012062 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 63737012063 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737012064 putative di-iron ligands [ion binding]; other site 63737012065 pyruvate kinase; Provisional; Region: PRK06354 63737012066 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 63737012067 domain interfaces; other site 63737012068 active site 63737012069 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 63737012070 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 63737012071 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 63737012072 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 63737012073 protein binding site [polypeptide binding]; other site 63737012074 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 63737012075 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 63737012076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737012077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737012078 active site 63737012079 ATP binding site [chemical binding]; other site 63737012080 substrate binding site [chemical binding]; other site 63737012081 activation loop (A-loop); other site 63737012082 Protein kinase domain; Region: Pkinase; pfam00069 63737012083 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737012084 active site 63737012085 ATP binding site [chemical binding]; other site 63737012086 substrate binding site [chemical binding]; other site 63737012087 activation loop (A-loop); other site 63737012088 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 63737012089 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 63737012090 putative active site [active] 63737012091 homotetrameric interface [polypeptide binding]; other site 63737012092 metal binding site [ion binding]; metal-binding site 63737012093 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 63737012094 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 63737012095 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 63737012096 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 63737012097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737012098 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 63737012099 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737012100 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 63737012101 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 63737012102 Hexamer interface [polypeptide binding]; other site 63737012103 Hexagonal pore residue; other site 63737012104 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 63737012105 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 63737012106 Hexamer interface [polypeptide binding]; other site 63737012107 Hexagonal pore residue; other site 63737012108 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 63737012109 Hexamer/Pentamer interface [polypeptide binding]; other site 63737012110 central pore; other site 63737012111 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 63737012112 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 63737012113 trimer interface [polypeptide binding]; other site 63737012114 active site 63737012115 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 63737012116 putative multimerization interface [polypeptide binding]; other site 63737012117 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 63737012118 putative multimerization interface [polypeptide binding]; other site 63737012119 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 63737012120 putative multimerization interface [polypeptide binding]; other site 63737012121 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 63737012122 putative multimerization interface [polypeptide binding]; other site 63737012123 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737012124 putative trimer interface [polypeptide binding]; other site 63737012125 putative CoA binding site [chemical binding]; other site 63737012126 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 63737012127 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 63737012128 Hexamer interface [polypeptide binding]; other site 63737012129 Hexagonal pore residue; other site 63737012130 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 63737012131 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 63737012132 Hexamer interface [polypeptide binding]; other site 63737012133 Hexagonal pore residue; other site 63737012134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 63737012135 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737012136 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 63737012137 putative dimerization interface [polypeptide binding]; other site 63737012138 conserved hypothetical protein; Region: TIGR02231 63737012139 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 63737012140 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 63737012141 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737012142 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737012143 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 63737012144 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 63737012145 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 63737012146 trmE is a tRNA modification GTPase; Region: trmE; cd04164 63737012147 G1 box; other site 63737012148 GTP/Mg2+ binding site [chemical binding]; other site 63737012149 Switch I region; other site 63737012150 G2 box; other site 63737012151 Switch II region; other site 63737012152 G3 box; other site 63737012153 G4 box; other site 63737012154 G5 box; other site 63737012155 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 63737012156 C factor cell-cell signaling protein; Provisional; Region: PRK09009 63737012157 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 63737012158 NADP binding site [chemical binding]; other site 63737012159 homodimer interface [polypeptide binding]; other site 63737012160 active site 63737012161 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 63737012162 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 63737012163 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737012164 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 63737012165 nucleophilic elbow; other site 63737012166 catalytic triad; other site 63737012167 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737012168 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 63737012169 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 63737012170 putative acyl-acceptor binding pocket; other site 63737012171 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 63737012172 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 63737012173 active site 63737012174 catalytic site [active] 63737012175 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 63737012176 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 63737012177 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 63737012178 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 63737012179 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 63737012180 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 63737012181 putative active site [active] 63737012182 catalytic residue [active] 63737012183 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 63737012184 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 63737012185 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 63737012186 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 63737012187 dihydropteroate synthase; Region: DHPS; TIGR01496 63737012188 substrate binding pocket [chemical binding]; other site 63737012189 dimer interface [polypeptide binding]; other site 63737012190 inhibitor binding site; inhibition site 63737012191 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 63737012192 triosephosphate isomerase; Provisional; Region: PRK14565 63737012193 substrate binding site [chemical binding]; other site 63737012194 dimer interface [polypeptide binding]; other site 63737012195 catalytic triad [active] 63737012196 Dynamin family; Region: Dynamin_N; pfam00350 63737012197 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 63737012198 G1 box; other site 63737012199 GTP/Mg2+ binding site [chemical binding]; other site 63737012200 Switch I region; other site 63737012201 G2 box; other site 63737012202 Switch II region; other site 63737012203 G3 box; other site 63737012204 G4 box; other site 63737012205 G5 box; other site 63737012206 Domain of unknown function (DUF697); Region: DUF697; pfam05128 63737012207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737012208 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737012209 Walker A motif; other site 63737012210 ATP binding site [chemical binding]; other site 63737012211 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012212 binding surface 63737012213 TPR motif; other site 63737012214 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 63737012215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012216 binding surface 63737012217 TPR motif; other site 63737012218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012219 binding surface 63737012220 TPR motif; other site 63737012221 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012222 binding surface 63737012223 TPR motif; other site 63737012224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012225 binding surface 63737012226 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737012227 TPR motif; other site 63737012228 Conserved TM helix; Region: TM_helix; pfam05552 63737012229 Conserved TM helix; Region: TM_helix; pfam05552 63737012230 Conserved TM helix; Region: TM_helix; pfam05552 63737012231 Conserved TM helix; Region: TM_helix; pfam05552 63737012232 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 63737012233 hydrophobic ligand binding site; other site 63737012234 Uncharacterized conserved protein [Function unknown]; Region: COG2912 63737012235 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 63737012236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012237 binding surface 63737012238 TPR motif; other site 63737012239 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737012240 XisI protein; Region: XisI; pfam08869 63737012241 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 63737012242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737012243 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 63737012244 dimerization interface [polypeptide binding]; other site 63737012245 substrate binding pocket [chemical binding]; other site 63737012246 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 63737012247 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 63737012248 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737012249 FeS/SAM binding site; other site 63737012250 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737012251 anti sigma factor interaction site; other site 63737012252 regulatory phosphorylation site [posttranslational modification]; other site 63737012253 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 63737012254 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737012255 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737012256 G1 box; other site 63737012257 GTP/Mg2+ binding site [chemical binding]; other site 63737012258 G2 box; other site 63737012259 Switch I region; other site 63737012260 Switch II region; other site 63737012261 G4 box; other site 63737012262 G5 box; other site 63737012263 Domain of unknown function (DUF697); Region: DUF697; pfam05128 63737012264 L-asparaginase II; Region: Asparaginase_II; cl01842 63737012265 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 63737012266 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 63737012267 putative glycosyl transferase; Provisional; Region: PRK10307 63737012268 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 63737012269 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 63737012270 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737012271 cofactor binding site; other site 63737012272 DNA binding site [nucleotide binding] 63737012273 substrate interaction site [chemical binding]; other site 63737012274 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 63737012275 intersubunit interface [polypeptide binding]; other site 63737012276 active site 63737012277 catalytic residue [active] 63737012278 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737012279 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737012280 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 63737012281 Recombination protein O N terminal; Region: RecO_N; pfam11967 63737012282 Recombination protein O C terminal; Region: RecO_C; pfam02565 63737012283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737012284 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737012285 putative substrate translocation pore; other site 63737012286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737012287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737012288 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 63737012289 active site 63737012290 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 63737012291 phosphoglyceromutase; Provisional; Region: PRK05434 63737012292 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 63737012293 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 63737012294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737012295 Walker A/P-loop; other site 63737012296 ATP binding site [chemical binding]; other site 63737012297 Q-loop/lid; other site 63737012298 ABC transporter signature motif; other site 63737012299 Walker B; other site 63737012300 D-loop; other site 63737012301 H-loop/switch region; other site 63737012302 ABC transporter; Region: ABC_tran_2; pfam12848 63737012303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 63737012304 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 63737012305 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 63737012306 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737012307 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 63737012308 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737012309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737012310 non-specific DNA binding site [nucleotide binding]; other site 63737012311 salt bridge; other site 63737012312 sequence-specific DNA binding site [nucleotide binding]; other site 63737012313 peptide chain release factor 1; Validated; Region: prfA; PRK00591 63737012314 This domain is found in peptide chain release factors; Region: PCRF; smart00937 63737012315 RF-1 domain; Region: RF-1; pfam00472 63737012316 ribosomal protein L31; Validated; Region: rpl31; CHL00136 63737012317 ribosomal protein S9; Region: rps9; CHL00079 63737012318 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 63737012319 23S rRNA interface [nucleotide binding]; other site 63737012320 L3 interface [polypeptide binding]; other site 63737012321 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 63737012322 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 63737012323 dimerization interface 3.5A [polypeptide binding]; other site 63737012324 active site 63737012325 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 63737012326 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 63737012327 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 63737012328 alphaNTD - beta interaction site [polypeptide binding]; other site 63737012329 alphaNTD homodimer interface [polypeptide binding]; other site 63737012330 alphaNTD - beta' interaction site [polypeptide binding]; other site 63737012331 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 63737012332 30S ribosomal protein S11; Validated; Region: PRK05309 63737012333 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 63737012334 30S ribosomal protein S13; Region: bact_S13; TIGR03631 63737012335 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 63737012336 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 63737012337 rRNA binding site [nucleotide binding]; other site 63737012338 predicted 30S ribosome binding site; other site 63737012339 adenylate kinase; Provisional; Region: adk; PRK02496 63737012340 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 63737012341 AMP-binding site [chemical binding]; other site 63737012342 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 63737012343 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 63737012344 SecY translocase; Region: SecY; pfam00344 63737012345 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 63737012346 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 63737012347 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 63737012348 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 63737012349 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 63737012350 5S rRNA interface [nucleotide binding]; other site 63737012351 23S rRNA interface [nucleotide binding]; other site 63737012352 L5 interface [polypeptide binding]; other site 63737012353 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 63737012354 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 63737012355 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 63737012356 ribosomal protein S8; Region: rps8; CHL00042 63737012357 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 63737012358 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 63737012359 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 63737012360 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 63737012361 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 63737012362 RNA binding site [nucleotide binding]; other site 63737012363 ribosomal protein L14; Region: rpl14; CHL00057 63737012364 ribosomal protein S17; Validated; Region: rps17; CHL00142 63737012365 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 63737012366 23S rRNA interface [nucleotide binding]; other site 63737012367 putative translocon interaction site; other site 63737012368 signal recognition particle (SRP54) interaction site; other site 63737012369 L23 interface [polypeptide binding]; other site 63737012370 trigger factor interaction site; other site 63737012371 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 63737012372 23S rRNA interface [nucleotide binding]; other site 63737012373 5S rRNA interface [nucleotide binding]; other site 63737012374 putative antibiotic binding site [chemical binding]; other site 63737012375 L25 interface [polypeptide binding]; other site 63737012376 L27 interface [polypeptide binding]; other site 63737012377 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 63737012378 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 63737012379 G-X-X-G motif; other site 63737012380 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 63737012381 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 63737012382 putative translocon binding site; other site 63737012383 protein-rRNA interface [nucleotide binding]; other site 63737012384 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 63737012385 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 63737012386 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 63737012387 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 63737012388 ribosomal protein L23; Region: rpl23; CHL00030 63737012389 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 63737012390 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 63737012391 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 63737012392 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 63737012393 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 63737012394 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 63737012395 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 63737012396 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 63737012397 TPP-binding site [chemical binding]; other site 63737012398 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 63737012399 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 63737012400 PYR/PP interface [polypeptide binding]; other site 63737012401 dimer interface [polypeptide binding]; other site 63737012402 TPP binding site [chemical binding]; other site 63737012403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 63737012404 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737012405 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737012406 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 63737012407 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 63737012408 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 63737012409 Ligand Binding Site [chemical binding]; other site 63737012410 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 63737012411 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 63737012412 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 63737012413 active site 63737012414 catalytic triad [active] 63737012415 oxyanion hole [active] 63737012416 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 63737012417 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 63737012418 substrate binding site [chemical binding]; other site 63737012419 glutamase interaction surface [polypeptide binding]; other site 63737012420 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 63737012421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737012422 Walker A motif; other site 63737012423 ATP binding site [chemical binding]; other site 63737012424 Walker B motif; other site 63737012425 arginine finger; other site 63737012426 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 63737012427 TPR repeat; Region: TPR_11; pfam13414 63737012428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012429 binding surface 63737012430 TPR motif; other site 63737012431 TPR repeat; Region: TPR_11; pfam13414 63737012432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012433 binding surface 63737012434 TPR motif; other site 63737012435 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 63737012436 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737012437 Cytochrome P450; Region: p450; pfam00067 63737012438 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 63737012439 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737012440 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737012441 hypothetical protein; Provisional; Region: PRK02724 63737012442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737012443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737012444 active site 63737012445 ATP binding site [chemical binding]; other site 63737012446 substrate binding site [chemical binding]; other site 63737012447 activation loop (A-loop); other site 63737012448 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737012449 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737012450 structural tetrad; other site 63737012451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 63737012452 SPFH domain / Band 7 family; Region: Band_7; pfam01145 63737012453 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 63737012454 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 63737012455 gamma subunit interface [polypeptide binding]; other site 63737012456 epsilon subunit interface [polypeptide binding]; other site 63737012457 LBP interface [polypeptide binding]; other site 63737012458 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 63737012459 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 63737012460 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 63737012461 alpha subunit interaction interface [polypeptide binding]; other site 63737012462 Walker A motif; other site 63737012463 ATP binding site [chemical binding]; other site 63737012464 Walker B motif; other site 63737012465 inhibitor binding site; inhibition site 63737012466 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 63737012467 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 63737012468 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 63737012469 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 63737012470 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 63737012471 P-loop; other site 63737012472 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 63737012473 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 63737012474 Clp amino terminal domain; Region: Clp_N; pfam02861 63737012475 Clp amino terminal domain; Region: Clp_N; pfam02861 63737012476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737012477 Walker A motif; other site 63737012478 ATP binding site [chemical binding]; other site 63737012479 Walker B motif; other site 63737012480 arginine finger; other site 63737012481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737012482 Walker A motif; other site 63737012483 ATP binding site [chemical binding]; other site 63737012484 Walker B motif; other site 63737012485 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 63737012486 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 63737012487 hydrophobic ligand binding site; other site 63737012488 Rubredoxin [Energy production and conversion]; Region: COG1773 63737012489 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 63737012490 iron binding site [ion binding]; other site 63737012491 flavoprotein, HI0933 family; Region: TIGR00275 63737012492 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 63737012493 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 63737012494 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 63737012495 trimer interface [polypeptide binding]; other site 63737012496 active site 63737012497 UDP-GlcNAc binding site [chemical binding]; other site 63737012498 lipid binding site [chemical binding]; lipid-binding site 63737012499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 63737012500 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 63737012501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737012502 S-adenosylmethionine binding site [chemical binding]; other site 63737012503 Response regulator receiver domain; Region: Response_reg; pfam00072 63737012504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737012505 active site 63737012506 phosphorylation site [posttranslational modification] 63737012507 intermolecular recognition site; other site 63737012508 dimerization interface [polypeptide binding]; other site 63737012509 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737012510 GAF domain; Region: GAF; pfam01590 63737012511 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737012512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737012513 Walker A motif; other site 63737012514 ATP binding site [chemical binding]; other site 63737012515 Walker B motif; other site 63737012516 arginine finger; other site 63737012517 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 63737012518 Family description; Region: UvrD_C_2; pfam13538 63737012519 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 63737012520 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 63737012521 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 63737012522 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 63737012523 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 63737012524 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 63737012525 homodimer interface [polypeptide binding]; other site 63737012526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737012527 catalytic residue [active] 63737012528 Response regulator receiver domain; Region: Response_reg; pfam00072 63737012529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737012530 active site 63737012531 phosphorylation site [posttranslational modification] 63737012532 intermolecular recognition site; other site 63737012533 dimerization interface [polypeptide binding]; other site 63737012534 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 63737012535 Permease; Region: Permease; pfam02405 63737012536 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 63737012537 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 63737012538 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 63737012539 Walker A/P-loop; other site 63737012540 ATP binding site [chemical binding]; other site 63737012541 Q-loop/lid; other site 63737012542 ABC transporter signature motif; other site 63737012543 Walker B; other site 63737012544 D-loop; other site 63737012545 H-loop/switch region; other site 63737012546 TOBE domain; Region: TOBE_2; pfam08402 63737012547 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 63737012548 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 63737012549 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737012550 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 63737012551 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 63737012552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737012553 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 63737012554 Beta-lactamase; Region: Beta-lactamase; pfam00144 63737012555 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 63737012556 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 63737012557 Predicted permeases [General function prediction only]; Region: COG0679 63737012558 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 63737012559 Glycoprotease family; Region: Peptidase_M22; pfam00814 63737012560 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 63737012561 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 63737012562 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 63737012563 active site 63737012564 NTP binding site [chemical binding]; other site 63737012565 metal binding triad [ion binding]; metal-binding site 63737012566 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 63737012567 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 63737012568 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737012569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737012570 active site 63737012571 phosphorylation site [posttranslational modification] 63737012572 intermolecular recognition site; other site 63737012573 dimerization interface [polypeptide binding]; other site 63737012574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012575 TPR repeat; Region: TPR_11; pfam13414 63737012576 binding surface 63737012577 TPR motif; other site 63737012578 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 63737012579 FAD binding domain; Region: FAD_binding_4; pfam01565 63737012580 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 63737012581 dimer interface [polypeptide binding]; other site 63737012582 substrate binding site [chemical binding]; other site 63737012583 ATP binding site [chemical binding]; other site 63737012584 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 63737012585 Nitrogen regulatory protein P-II; Region: P-II; smart00938 63737012586 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 63737012587 active site 63737012588 dimerization interface [polypeptide binding]; other site 63737012589 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 63737012590 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 63737012591 active site 63737012592 substrate binding site [chemical binding]; other site 63737012593 metal binding site [ion binding]; metal-binding site 63737012594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737012595 NACHT domain; Region: NACHT; pfam05729 63737012596 Walker A/P-loop; other site 63737012597 ATP binding site [chemical binding]; other site 63737012598 Q-loop/lid; other site 63737012599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012601 TPR motif; other site 63737012602 binding surface 63737012603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012605 binding surface 63737012606 TPR motif; other site 63737012607 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012609 TPR motif; other site 63737012610 binding surface 63737012611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012612 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012614 binding surface 63737012615 TPR motif; other site 63737012616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012619 binding surface 63737012620 TPR motif; other site 63737012621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012623 binding surface 63737012624 TPR motif; other site 63737012625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737012626 TPR repeat; Region: TPR_11; pfam13414 63737012627 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737012628 Mg binding site [ion binding]; other site 63737012629 nucleotide binding site [chemical binding]; other site 63737012630 putative protofilament interface [polypeptide binding]; other site 63737012631 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 63737012632 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 63737012633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737012634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737012635 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 63737012636 Ligand Binding Site [chemical binding]; other site 63737012637 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 63737012638 Domain of unknown function DUF21; Region: DUF21; pfam01595 63737012639 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 63737012640 Transporter associated domain; Region: CorC_HlyC; smart01091 63737012641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 63737012642 active site 63737012643 ornithine carbamoyltransferase; Provisional; Region: PRK00779 63737012644 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 63737012645 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 63737012646 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 63737012647 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 63737012648 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 63737012649 Catalytic site [active] 63737012650 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 63737012651 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737012652 ATP binding site [chemical binding]; other site 63737012653 putative Mg++ binding site [ion binding]; other site 63737012654 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737012655 nucleotide binding region [chemical binding]; other site 63737012656 ATP-binding site [chemical binding]; other site 63737012657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737012658 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 63737012659 Walker A/P-loop; other site 63737012660 ATP binding site [chemical binding]; other site 63737012661 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 63737012662 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 63737012663 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737012664 putative active site [active] 63737012665 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 63737012666 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 63737012667 DGQHR domain; Region: DGQHR; TIGR03187 63737012668 DGQHR domain; Region: DGQHR; TIGR03187 63737012669 DNA-sulfur modification-associated; Region: DndB; cl17621 63737012670 hypothetical protein; Provisional; Region: PRK06850 63737012671 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 63737012672 Active Sites [active] 63737012673 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 63737012674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737012675 Walker A/P-loop; other site 63737012676 ATP binding site [chemical binding]; other site 63737012677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737012678 ABC transporter signature motif; other site 63737012679 Walker B; other site 63737012680 D-loop; other site 63737012681 H-loop/switch region; other site 63737012682 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 63737012683 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 63737012684 muropeptide transporter; Validated; Region: ampG; cl17669 63737012685 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737012686 Coenzyme A binding pocket [chemical binding]; other site 63737012687 HEAT repeats; Region: HEAT_2; pfam13646 63737012688 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 63737012689 HEAT repeats; Region: HEAT_2; pfam13646 63737012690 protein binding surface [polypeptide binding]; other site 63737012691 HEAT repeats; Region: HEAT_2; pfam13646 63737012692 Cupin domain; Region: Cupin_2; cl17218 63737012693 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 63737012694 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737012695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737012696 active site 63737012697 phosphorylation site [posttranslational modification] 63737012698 intermolecular recognition site; other site 63737012699 dimerization interface [polypeptide binding]; other site 63737012700 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737012701 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737012702 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 63737012703 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 63737012704 Protein of unknown function (DUF512); Region: DUF512; pfam04459 63737012705 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 63737012706 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 63737012707 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 63737012708 L-aspartate oxidase; Provisional; Region: PRK07395 63737012709 L-aspartate oxidase; Provisional; Region: PRK06175 63737012710 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 63737012711 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737012712 CHASE2 domain; Region: CHASE2; pfam05226 63737012713 PAS fold; Region: PAS_4; pfam08448 63737012714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737012715 putative active site [active] 63737012716 heme pocket [chemical binding]; other site 63737012717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737012718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737012719 metal binding site [ion binding]; metal-binding site 63737012720 active site 63737012721 I-site; other site 63737012722 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 63737012723 substrate binding site [chemical binding]; other site 63737012724 putative active site [active] 63737012725 redox center [active] 63737012726 Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961 63737012727 catalytic residues [active] 63737012728 Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434 63737012729 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 63737012730 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 63737012731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737012732 FeS/SAM binding site; other site 63737012733 TRAM domain; Region: TRAM; cl01282 63737012734 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 63737012735 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 63737012736 ATP binding site [chemical binding]; other site 63737012737 Mg++ binding site [ion binding]; other site 63737012738 motif III; other site 63737012739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737012740 nucleotide binding region [chemical binding]; other site 63737012741 ATP-binding site [chemical binding]; other site 63737012742 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737012743 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737012744 active site 63737012745 catalytic tetrad [active] 63737012746 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 63737012747 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737012748 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 63737012749 PUCC protein; Region: PUCC; pfam03209 63737012750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737012751 putative substrate translocation pore; other site 63737012752 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 63737012753 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 63737012754 active site 63737012755 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 63737012756 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737012757 putative NAD(P) binding site [chemical binding]; other site 63737012758 catalytic Zn binding site [ion binding]; other site 63737012759 structural Zn binding site [ion binding]; other site 63737012760 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 63737012761 UbiA prenyltransferase family; Region: UbiA; pfam01040 63737012762 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 63737012763 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737012764 P loop; other site 63737012765 Nucleotide binding site [chemical binding]; other site 63737012766 DTAP/Switch II; other site 63737012767 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 63737012768 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 63737012769 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 63737012770 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 63737012771 Walker A/P-loop; other site 63737012772 ATP binding site [chemical binding]; other site 63737012773 Q-loop/lid; other site 63737012774 ABC transporter signature motif; other site 63737012775 Walker B; other site 63737012776 D-loop; other site 63737012777 H-loop/switch region; other site 63737012778 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 63737012779 putative carbohydrate binding site [chemical binding]; other site 63737012780 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737012781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737012782 S-adenosylmethionine binding site [chemical binding]; other site 63737012783 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 63737012784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737012785 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737012786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737012787 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 63737012788 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737012789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737012790 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 63737012791 Ligand binding site; other site 63737012792 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 63737012793 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 63737012794 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 63737012795 Probable Catalytic site; other site 63737012796 metal-binding site 63737012797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737012798 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 63737012799 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 63737012800 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 63737012801 substrate binding site; other site 63737012802 metal-binding site 63737012803 Oligomer interface; other site 63737012804 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737012805 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 63737012806 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 63737012807 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 63737012808 NADP binding site [chemical binding]; other site 63737012809 active site 63737012810 putative substrate binding site [chemical binding]; other site 63737012811 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 63737012812 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 63737012813 Predicted transcriptional regulator [Transcription]; Region: COG3682 63737012814 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 63737012815 AAA ATPase domain; Region: AAA_16; pfam13191 63737012816 AAA ATPase domain; Region: AAA_16; pfam13191 63737012817 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 63737012818 YacP-like NYN domain; Region: NYN_YacP; cl01491 63737012819 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 63737012820 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 63737012821 Walker A/P-loop; other site 63737012822 ATP binding site [chemical binding]; other site 63737012823 Q-loop/lid; other site 63737012824 ABC transporter signature motif; other site 63737012825 Walker B; other site 63737012826 D-loop; other site 63737012827 H-loop/switch region; other site 63737012828 hypothetical protein; Provisional; Region: PRK13683 63737012829 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 63737012830 D1 interface; other site 63737012831 chlorophyll binding site; other site 63737012832 pheophytin binding site; other site 63737012833 beta carotene binding site; other site 63737012834 cytochrome b559 beta interface; other site 63737012835 quinone binding site; other site 63737012836 cytochrome b559 alpha interface; other site 63737012837 protein J interface; other site 63737012838 protein H interface; other site 63737012839 protein X interface; other site 63737012840 core light harvesting protein interface; other site 63737012841 protein L interface; other site 63737012842 CP43 interface; other site 63737012843 protein T interface; other site 63737012844 Fe binding site [ion binding]; other site 63737012845 protein M interface; other site 63737012846 Mn-stabilizing polypeptide interface; other site 63737012847 bromide binding site; other site 63737012848 cytochrome c-550 interface; other site 63737012849 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 63737012850 aromatic arch; other site 63737012851 DCoH dimer interaction site [polypeptide binding]; other site 63737012852 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 63737012853 DCoH tetramer interaction site [polypeptide binding]; other site 63737012854 substrate binding site [chemical binding]; other site 63737012855 S-layer homology domain; Region: SLH; pfam00395 63737012856 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737012857 AMIN domain; Region: AMIN; pfam11741 63737012858 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 63737012859 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 63737012860 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 63737012861 transketolase; Region: PLN02790 63737012862 TPP-binding site [chemical binding]; other site 63737012863 dimer interface [polypeptide binding]; other site 63737012864 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 63737012865 PYR/PP interface [polypeptide binding]; other site 63737012866 dimer interface [polypeptide binding]; other site 63737012867 TPP binding site [chemical binding]; other site 63737012868 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 63737012869 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 63737012870 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 63737012871 dimer interface [polypeptide binding]; other site 63737012872 active site 63737012873 acyl carrier protein; Provisional; Region: acpP; PRK00982 63737012874 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 63737012875 Cysteine-rich domain; Region: CCG; pfam02754 63737012876 Cysteine-rich domain; Region: CCG; pfam02754 63737012877 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737012878 Cytochrome P450; Region: p450; cl12078 63737012879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737012880 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737012881 putative active site [active] 63737012882 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 63737012883 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 63737012884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 63737012885 Zn2+ binding site [ion binding]; other site 63737012886 Mg2+ binding site [ion binding]; other site 63737012887 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 63737012888 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 63737012889 Dehydroquinase class II; Region: DHquinase_II; pfam01220 63737012890 trimer interface [polypeptide binding]; other site 63737012891 active site 63737012892 dimer interface [polypeptide binding]; other site 63737012893 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 63737012894 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 63737012895 active site 63737012896 interdomain interaction site; other site 63737012897 putative metal-binding site [ion binding]; other site 63737012898 nucleotide binding site [chemical binding]; other site 63737012899 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 63737012900 domain I; other site 63737012901 phosphate binding site [ion binding]; other site 63737012902 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 63737012903 domain II; other site 63737012904 domain III; other site 63737012905 nucleotide binding site [chemical binding]; other site 63737012906 DNA binding groove [nucleotide binding] 63737012907 catalytic site [active] 63737012908 domain IV; other site 63737012909 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 63737012910 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 63737012911 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 63737012912 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 63737012913 S-layer homology domain; Region: SLH; pfam00395 63737012914 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737012915 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 63737012916 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 63737012917 metal binding site [ion binding]; metal-binding site 63737012918 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 63737012919 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 63737012920 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 63737012921 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 63737012922 ABC-ATPase subunit interface; other site 63737012923 dimer interface [polypeptide binding]; other site 63737012924 putative PBP binding regions; other site 63737012925 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 63737012926 Domain of unknown function (DUF814); Region: DUF814; pfam05670 63737012927 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 63737012928 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 63737012929 putative ADP-binding pocket [chemical binding]; other site 63737012930 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 63737012931 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 63737012932 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 63737012933 Ferritin-like domain; Region: Ferritin; pfam00210 63737012934 dimanganese center [ion binding]; other site 63737012935 Predicted membrane protein [Function unknown]; Region: COG2261 63737012936 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 63737012937 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737012938 FeS/SAM binding site; other site 63737012939 HemN C-terminal domain; Region: HemN_C; pfam06969 63737012940 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 63737012941 heme binding pocket [chemical binding]; other site 63737012942 heme ligand [chemical binding]; other site 63737012943 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 63737012944 active site 63737012945 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 63737012946 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737012947 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737012948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737012949 sequence-specific DNA binding site [nucleotide binding]; other site 63737012950 salt bridge; other site 63737012951 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 63737012952 starch-binding site 2 [chemical binding]; other site 63737012953 starch-binding site 1 [chemical binding]; other site 63737012954 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 63737012955 active site 63737012956 catalytic triad [active] 63737012957 oxyanion hole [active] 63737012958 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 63737012959 PIN domain; Region: PIN; pfam01850 63737012960 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 63737012961 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 63737012962 acyl-activating enzyme (AAE) consensus motif; other site 63737012963 active site 63737012964 AMP binding site [chemical binding]; other site 63737012965 CoA binding site [chemical binding]; other site 63737012966 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 63737012967 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 63737012968 oligomer interface [polypeptide binding]; other site 63737012969 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737012970 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737012971 active site 63737012972 ATP binding site [chemical binding]; other site 63737012973 substrate binding site [chemical binding]; other site 63737012974 activation loop (A-loop); other site 63737012975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012976 binding surface 63737012977 TPR motif; other site 63737012978 TPR repeat; Region: TPR_11; pfam13414 63737012979 TPR repeat; Region: TPR_11; pfam13414 63737012980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012981 binding surface 63737012982 TPR motif; other site 63737012983 TPR repeat; Region: TPR_11; pfam13414 63737012984 TPR repeat; Region: TPR_11; pfam13414 63737012985 TPR repeat; Region: TPR_11; pfam13414 63737012986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737012987 binding surface 63737012988 TPR motif; other site 63737012989 aspartate kinase; Provisional; Region: PRK07431 63737012990 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 63737012991 putative nucleotide binding site [chemical binding]; other site 63737012992 putative catalytic residues [active] 63737012993 putative Mg ion binding site [ion binding]; other site 63737012994 putative aspartate binding site [chemical binding]; other site 63737012995 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 63737012996 putative allosteric regulatory site; other site 63737012997 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 63737012998 putative allosteric regulatory residue; other site 63737012999 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 63737013000 putative allosteric regulatory site; other site 63737013001 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 63737013002 putative allosteric regulatory residue; other site 63737013003 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737013004 putative active site [active] 63737013005 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 63737013006 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 63737013007 YcfA-like protein; Region: YcfA; pfam07927 63737013008 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 63737013009 NB-ARC domain; Region: NB-ARC; pfam00931 63737013010 Tetratricopeptide repeat; Region: TPR_10; pfam13374 63737013011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013013 binding surface 63737013014 TPR motif; other site 63737013015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013018 binding surface 63737013019 TPR motif; other site 63737013020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013022 Tetratricopeptide repeat; Region: TPR_10; pfam13374 63737013023 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013024 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013025 binding surface 63737013026 TPR motif; other site 63737013027 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013028 RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717 63737013029 Predicted integral membrane protein [Function unknown]; Region: COG0392 63737013030 Putative esterase; Region: Esterase; pfam00756 63737013031 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 63737013032 Putative esterase; Region: Esterase; pfam00756 63737013033 Uncharacterized conserved protein [Function unknown]; Region: COG2898 63737013034 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 63737013035 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 63737013036 Peptidase family M50; Region: Peptidase_M50; pfam02163 63737013037 active site 63737013038 putative substrate binding region [chemical binding]; other site 63737013039 Protein of unknown function, DUF485; Region: DUF485; pfam04341 63737013040 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 63737013041 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 63737013042 Na binding site [ion binding]; other site 63737013043 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 63737013044 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 63737013045 putative ligand binding site [chemical binding]; other site 63737013046 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 63737013047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 63737013048 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 63737013049 TM-ABC transporter signature motif; other site 63737013050 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 63737013051 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 63737013052 TM-ABC transporter signature motif; other site 63737013053 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 63737013054 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 63737013055 Walker A/P-loop; other site 63737013056 ATP binding site [chemical binding]; other site 63737013057 Q-loop/lid; other site 63737013058 ABC transporter signature motif; other site 63737013059 Walker B; other site 63737013060 D-loop; other site 63737013061 H-loop/switch region; other site 63737013062 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 63737013063 active site 63737013064 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737013065 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737013066 putative active site [active] 63737013067 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 63737013068 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 63737013069 Walker A/P-loop; other site 63737013070 ATP binding site [chemical binding]; other site 63737013071 Q-loop/lid; other site 63737013072 ABC transporter signature motif; other site 63737013073 Walker B; other site 63737013074 D-loop; other site 63737013075 H-loop/switch region; other site 63737013076 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737013077 Cytochrome P450; Region: p450; cl12078 63737013078 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 63737013079 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 63737013080 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 63737013081 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 63737013082 acetolactate synthase; Reviewed; Region: PRK08322 63737013083 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737013084 PYR/PP interface [polypeptide binding]; other site 63737013085 dimer interface [polypeptide binding]; other site 63737013086 TPP binding site [chemical binding]; other site 63737013087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737013088 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 63737013089 TPP-binding site [chemical binding]; other site 63737013090 dimer interface [polypeptide binding]; other site 63737013091 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 63737013092 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 63737013093 NAD(P) binding site [chemical binding]; other site 63737013094 catalytic residues [active] 63737013095 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 63737013096 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 63737013097 phosphopeptide binding site; other site 63737013098 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737013099 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737013100 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 63737013101 cyclase homology domain; Region: CHD; cd07302 63737013102 nucleotidyl binding site; other site 63737013103 metal binding site [ion binding]; metal-binding site 63737013104 dimer interface [polypeptide binding]; other site 63737013105 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 63737013106 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 63737013107 GTP/Mg2+ binding site [chemical binding]; other site 63737013108 G4 box; other site 63737013109 G5 box; other site 63737013110 G1 box; other site 63737013111 Switch I region; other site 63737013112 G2 box; other site 63737013113 G3 box; other site 63737013114 Switch II region; other site 63737013115 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737013116 active site 63737013117 Uncharacterized conserved protein [Function unknown]; Region: COG0062 63737013118 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 63737013119 putative substrate binding site [chemical binding]; other site 63737013120 putative ATP binding site [chemical binding]; other site 63737013121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 63737013122 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 63737013123 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737013124 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 63737013125 active site 63737013126 catalytic residues [active] 63737013127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737013128 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737013129 active site 63737013130 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 63737013131 16S rRNA methyltransferase B; Provisional; Region: PRK14901 63737013132 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 63737013133 putative RNA binding site [nucleotide binding]; other site 63737013134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737013135 S-adenosylmethionine binding site [chemical binding]; other site 63737013136 tellurium resistance terB-like protein; Region: terB_like; cd07177 63737013137 metal binding site [ion binding]; metal-binding site 63737013138 Transglycosylase; Region: Transgly; pfam00912 63737013139 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 63737013140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 63737013141 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 63737013142 catalytic center binding site [active] 63737013143 ATP binding site [chemical binding]; other site 63737013144 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 63737013145 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 63737013146 dimer interface [polypeptide binding]; other site 63737013147 ADP-ribose binding site [chemical binding]; other site 63737013148 active site 63737013149 nudix motif; other site 63737013150 metal binding site [ion binding]; metal-binding site 63737013151 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 63737013152 Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein). Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401 63737013153 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 63737013154 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 63737013155 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 63737013156 active site 63737013157 Double zinc ribbon; Region: DZR; pfam12773 63737013158 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 63737013159 catalytic triad [active] 63737013160 dimer interface [polypeptide binding]; other site 63737013161 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 63737013162 GSH binding site [chemical binding]; other site 63737013163 catalytic residues [active] 63737013164 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737013165 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737013166 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 63737013167 putative NAD(P) binding site [chemical binding]; other site 63737013168 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 63737013169 catalytic residues [active] 63737013170 dimer interface [polypeptide binding]; other site 63737013171 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 63737013172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 63737013173 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737013174 HEAT repeats; Region: HEAT_2; pfam13646 63737013175 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 63737013176 EamA-like transporter family; Region: EamA; pfam00892 63737013177 EamA-like transporter family; Region: EamA; pfam00892 63737013178 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 63737013179 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 63737013180 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 63737013181 UbiA prenyltransferase family; Region: UbiA; pfam01040 63737013182 Thioredoxin; Region: Thioredoxin_4; pfam13462 63737013183 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 63737013184 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737013185 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737013186 Uncharacterized conserved protein [Function unknown]; Region: COG4748 63737013187 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 63737013188 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 63737013189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737013190 Walker A/P-loop; other site 63737013191 ATP binding site [chemical binding]; other site 63737013192 Q-loop/lid; other site 63737013193 ABC transporter signature motif; other site 63737013194 Walker B; other site 63737013195 D-loop; other site 63737013196 H-loop/switch region; other site 63737013197 ABC-2 type transporter; Region: ABC2_membrane; cl17235 63737013198 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 63737013199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 63737013200 MarR family; Region: MarR; pfam01047 63737013201 enterobactin exporter EntS; Provisional; Region: PRK10489 63737013202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737013203 putative substrate translocation pore; other site 63737013204 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 63737013205 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 63737013206 Walker A/P-loop; other site 63737013207 ATP binding site [chemical binding]; other site 63737013208 Q-loop/lid; other site 63737013209 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 63737013210 ABC transporter signature motif; other site 63737013211 Walker B; other site 63737013212 D-loop; other site 63737013213 H-loop/switch region; other site 63737013214 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 63737013215 ABC1 family; Region: ABC1; pfam03109 63737013216 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 63737013217 active site 63737013218 ATP binding site [chemical binding]; other site 63737013219 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 63737013220 ligand-binding site [chemical binding]; other site 63737013221 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737013222 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737013223 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 63737013224 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 63737013225 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 63737013226 HIGH motif; other site 63737013227 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 63737013228 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 63737013229 active site 63737013230 KMSKS motif; other site 63737013231 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 63737013232 tRNA binding surface [nucleotide binding]; other site 63737013233 anticodon binding site; other site 63737013234 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 63737013235 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 63737013236 muropeptide transporter; Reviewed; Region: ampG; PRK11902 63737013237 muropeptide transporter; Validated; Region: ampG; cl17669 63737013238 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 63737013239 nucleotide binding site [chemical binding]; other site 63737013240 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 63737013241 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 63737013242 GH3 auxin-responsive promoter; Region: GH3; pfam03321 63737013243 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 63737013244 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737013245 putative trimer interface [polypeptide binding]; other site 63737013246 putative CoA binding site [chemical binding]; other site 63737013247 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 63737013248 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 63737013249 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737013250 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 63737013251 [2Fe-2S] cluster binding site [ion binding]; other site 63737013252 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 63737013253 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737013254 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 63737013255 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013256 secreted effector protein PipB2; Provisional; Region: PRK15196 63737013257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013258 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737013259 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013260 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737013261 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737013262 catalytic loop [active] 63737013263 iron binding site [ion binding]; other site 63737013264 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 63737013265 dinuclear metal binding motif [ion binding]; other site 63737013266 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737013267 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 63737013268 [2Fe-2S] cluster binding site [ion binding]; other site 63737013269 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737013270 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 63737013271 [2Fe-2S] cluster binding site [ion binding]; other site 63737013272 Uracil DNA glycosylase superfamily; Region: UDG; smart00986 63737013273 ligand binding site [chemical binding]; other site 63737013274 active site 63737013275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737013276 non-specific DNA binding site [nucleotide binding]; other site 63737013277 salt bridge; other site 63737013278 sequence-specific DNA binding site [nucleotide binding]; other site 63737013279 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 63737013280 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 63737013281 active site 63737013282 putative substrate binding pocket [chemical binding]; other site 63737013283 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737013284 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 63737013285 oligomeric interface; other site 63737013286 putative active site [active] 63737013287 homodimer interface [polypeptide binding]; other site 63737013288 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 63737013289 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 63737013290 DXD motif; other site 63737013291 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 63737013292 SnoaL-like domain; Region: SnoaL_3; pfam13474 63737013293 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 63737013294 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 63737013295 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 63737013296 active site 63737013297 catalytic site [active] 63737013298 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 63737013299 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 63737013300 putative ADP-binding pocket [chemical binding]; other site 63737013301 Peptidase family M48; Region: Peptidase_M48; cl12018 63737013302 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737013303 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 63737013304 TAP-like protein; Region: Abhydrolase_4; pfam08386 63737013305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737013306 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 63737013307 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 63737013308 Cl- selectivity filter; other site 63737013309 Cl- binding residues [ion binding]; other site 63737013310 pore gating glutamate residue; other site 63737013311 dimer interface [polypeptide binding]; other site 63737013312 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 63737013313 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 63737013314 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 63737013315 TM-ABC transporter signature motif; other site 63737013316 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 63737013317 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 63737013318 TM-ABC transporter signature motif; other site 63737013319 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737013320 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737013321 putative active site [active] 63737013322 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 63737013323 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 63737013324 Walker A/P-loop; other site 63737013325 ATP binding site [chemical binding]; other site 63737013326 Q-loop/lid; other site 63737013327 ABC transporter signature motif; other site 63737013328 Walker B; other site 63737013329 D-loop; other site 63737013330 H-loop/switch region; other site 63737013331 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 63737013332 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 63737013333 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 63737013334 putative ligand binding site [chemical binding]; other site 63737013335 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737013336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737013337 Walker A motif; other site 63737013338 ATP binding site [chemical binding]; other site 63737013339 Walker B motif; other site 63737013340 arginine finger; other site 63737013341 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737013342 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737013343 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 63737013344 D-xylulose kinase; Region: XylB; TIGR01312 63737013345 nucleotide binding site [chemical binding]; other site 63737013346 Photosystem I protein M (PsaM); Region: PsaM; pfam07465 63737013347 TPR repeat; Region: TPR_11; pfam13414 63737013348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013349 binding surface 63737013350 TPR motif; other site 63737013351 TPR repeat; Region: TPR_11; pfam13414 63737013352 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737013353 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 63737013354 putative C-terminal domain interface [polypeptide binding]; other site 63737013355 putative GSH binding site (G-site) [chemical binding]; other site 63737013356 putative dimer interface [polypeptide binding]; other site 63737013357 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737013358 N-terminal domain interface [polypeptide binding]; other site 63737013359 dimer interface [polypeptide binding]; other site 63737013360 substrate binding pocket (H-site) [chemical binding]; other site 63737013361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 63737013362 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 63737013363 MAPEG family; Region: MAPEG; cl09190 63737013364 Predicted transcriptional regulators [Transcription]; Region: COG1695 63737013365 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 63737013366 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 63737013367 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 63737013368 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 63737013369 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737013370 DRTGG domain; Region: DRTGG; pfam07085 63737013371 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737013372 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737013373 active site 63737013374 catalytic tetrad [active] 63737013375 Response regulator receiver domain; Region: Response_reg; pfam00072 63737013376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013377 active site 63737013378 phosphorylation site [posttranslational modification] 63737013379 intermolecular recognition site; other site 63737013380 dimerization interface [polypeptide binding]; other site 63737013381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737013382 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737013383 putative active site [active] 63737013384 heme pocket [chemical binding]; other site 63737013385 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737013386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737013387 putative active site [active] 63737013388 heme pocket [chemical binding]; other site 63737013389 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737013390 putative active site [active] 63737013391 heme pocket [chemical binding]; other site 63737013392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737013393 PAS domain; Region: PAS_9; pfam13426 63737013394 putative active site [active] 63737013395 heme pocket [chemical binding]; other site 63737013396 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737013397 PAS domain; Region: PAS; smart00091 63737013398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737013399 dimer interface [polypeptide binding]; other site 63737013400 phosphorylation site [posttranslational modification] 63737013401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737013402 ATP binding site [chemical binding]; other site 63737013403 Mg2+ binding site [ion binding]; other site 63737013404 G-X-G motif; other site 63737013405 Response regulator receiver domain; Region: Response_reg; pfam00072 63737013406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013407 active site 63737013408 phosphorylation site [posttranslational modification] 63737013409 intermolecular recognition site; other site 63737013410 dimerization interface [polypeptide binding]; other site 63737013411 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737013412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013413 phosphorylation site [posttranslational modification] 63737013414 GAF domain; Region: GAF_2; pfam13185 63737013415 GAF domain; Region: GAF_3; pfam13492 63737013416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737013417 dimer interface [polypeptide binding]; other site 63737013418 phosphorylation site [posttranslational modification] 63737013419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737013420 ATP binding site [chemical binding]; other site 63737013421 Mg2+ binding site [ion binding]; other site 63737013422 G-X-G motif; other site 63737013423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737013424 Coenzyme A binding pocket [chemical binding]; other site 63737013425 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737013426 GAF domain; Region: GAF; pfam01590 63737013427 PAS domain S-box; Region: sensory_box; TIGR00229 63737013428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737013429 putative active site [active] 63737013430 heme pocket [chemical binding]; other site 63737013431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737013432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737013433 dimer interface [polypeptide binding]; other site 63737013434 phosphorylation site [posttranslational modification] 63737013435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737013436 ATP binding site [chemical binding]; other site 63737013437 Mg2+ binding site [ion binding]; other site 63737013438 G-X-G motif; other site 63737013439 Response regulator receiver domain; Region: Response_reg; pfam00072 63737013440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013441 active site 63737013442 phosphorylation site [posttranslational modification] 63737013443 intermolecular recognition site; other site 63737013444 dimerization interface [polypeptide binding]; other site 63737013445 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 63737013446 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 63737013447 cobalamin binding residues [chemical binding]; other site 63737013448 putative BtuC binding residues; other site 63737013449 dimer interface [polypeptide binding]; other site 63737013450 Predicted membrane protein [Function unknown]; Region: COG2119 63737013451 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 63737013452 Predicted membrane protein [Function unknown]; Region: COG2119 63737013453 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 63737013454 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 63737013455 hypothetical protein; Provisional; Region: PRK13686 63737013456 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 63737013457 DHH family; Region: DHH; pfam01368 63737013458 DHHA1 domain; Region: DHHA1; pfam02272 63737013459 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14265 63737013460 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 63737013461 Walker A/P-loop; other site 63737013462 ATP binding site [chemical binding]; other site 63737013463 Q-loop/lid; other site 63737013464 ABC transporter signature motif; other site 63737013465 Walker B; other site 63737013466 D-loop; other site 63737013467 H-loop/switch region; other site 63737013468 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 63737013469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737013470 dimer interface [polypeptide binding]; other site 63737013471 conserved gate region; other site 63737013472 putative PBP binding loops; other site 63737013473 ABC-ATPase subunit interface; other site 63737013474 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 63737013475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737013476 dimer interface [polypeptide binding]; other site 63737013477 conserved gate region; other site 63737013478 putative PBP binding loops; other site 63737013479 ABC-ATPase subunit interface; other site 63737013480 PBP superfamily domain; Region: PBP_like_2; cl17296 63737013481 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 63737013482 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 63737013483 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402 63737013484 TPR repeat; Region: TPR_11; pfam13414 63737013485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013486 binding surface 63737013487 TPR motif; other site 63737013488 TPR repeat; Region: TPR_11; pfam13414 63737013489 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013490 binding surface 63737013491 TPR motif; other site 63737013492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013493 TPR repeat; Region: TPR_11; pfam13414 63737013494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013495 binding surface 63737013496 TPR motif; other site 63737013497 TPR repeat; Region: TPR_11; pfam13414 63737013498 TPR repeat; Region: TPR_11; pfam13414 63737013499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013500 binding surface 63737013501 TPR motif; other site 63737013502 TPR repeat; Region: TPR_11; pfam13414 63737013503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013504 binding surface 63737013505 TPR motif; other site 63737013506 TPR repeat; Region: TPR_11; pfam13414 63737013507 TPR repeat; Region: TPR_11; pfam13414 63737013508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013509 binding surface 63737013510 TPR motif; other site 63737013511 TPR repeat; Region: TPR_11; pfam13414 63737013512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013513 binding surface 63737013514 TPR motif; other site 63737013515 TPR repeat; Region: TPR_11; pfam13414 63737013516 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 63737013517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737013518 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013519 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737013520 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013521 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737013522 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013523 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737013524 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013525 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737013526 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013527 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013528 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737013529 Response regulator receiver domain; Region: Response_reg; pfam00072 63737013530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013531 active site 63737013532 phosphorylation site [posttranslational modification] 63737013533 intermolecular recognition site; other site 63737013534 dimerization interface [polypeptide binding]; other site 63737013535 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737013536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013537 active site 63737013538 phosphorylation site [posttranslational modification] 63737013539 intermolecular recognition site; other site 63737013540 dimerization interface [polypeptide binding]; other site 63737013541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737013542 DNA binding site [nucleotide binding] 63737013543 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737013544 putative binding surface; other site 63737013545 active site 63737013546 Response regulator receiver domain; Region: Response_reg; pfam00072 63737013547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013548 active site 63737013549 phosphorylation site [posttranslational modification] 63737013550 intermolecular recognition site; other site 63737013551 dimerization interface [polypeptide binding]; other site 63737013552 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737013553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737013554 putative active site [active] 63737013555 heme pocket [chemical binding]; other site 63737013556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737013557 dimer interface [polypeptide binding]; other site 63737013558 phosphorylation site [posttranslational modification] 63737013559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737013560 ATP binding site [chemical binding]; other site 63737013561 Mg2+ binding site [ion binding]; other site 63737013562 G-X-G motif; other site 63737013563 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 63737013564 4Fe-4S binding domain; Region: Fer4; pfam00037 63737013565 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 63737013566 Uncharacterized conserved protein [Function unknown]; Region: COG5607 63737013567 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 63737013568 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737013569 GAF domain; Region: GAF; pfam01590 63737013570 Phytochrome region; Region: PHY; pfam00360 63737013571 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737013572 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737013573 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737013574 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737013575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737013576 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737013577 dimer interface [polypeptide binding]; other site 63737013578 phosphorylation site [posttranslational modification] 63737013579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737013580 ATP binding site [chemical binding]; other site 63737013581 Mg2+ binding site [ion binding]; other site 63737013582 G-X-G motif; other site 63737013583 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 63737013584 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737013585 P loop; other site 63737013586 Nucleotide binding site [chemical binding]; other site 63737013587 DTAP/Switch II; other site 63737013588 Switch I; other site 63737013589 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737013590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737013591 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737013592 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 63737013593 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 63737013594 transmembrane helices; other site 63737013595 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 63737013596 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 63737013597 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 63737013598 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 63737013599 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 63737013600 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 63737013601 active site 63737013602 SAM binding site [chemical binding]; other site 63737013603 homodimer interface [polypeptide binding]; other site 63737013604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737013605 non-specific DNA binding site [nucleotide binding]; other site 63737013606 salt bridge; other site 63737013607 sequence-specific DNA binding site [nucleotide binding]; other site 63737013608 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 63737013609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737013610 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 63737013611 DNA methylase; Region: N6_N4_Mtase; pfam01555 63737013612 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 63737013613 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 63737013614 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 63737013615 acyl-activating enzyme (AAE) consensus motif; other site 63737013616 acyl-activating enzyme (AAE) consensus motif; other site 63737013617 putative AMP binding site [chemical binding]; other site 63737013618 putative active site [active] 63737013619 putative CoA binding site [chemical binding]; other site 63737013620 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 63737013621 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 63737013622 putative ligand binding site [chemical binding]; other site 63737013623 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737013624 structural tetrad; other site 63737013625 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737013626 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737013627 structural tetrad; other site 63737013628 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737013629 WD domain, G-beta repeat; Region: WD40; pfam00400 63737013630 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 63737013631 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 63737013632 Predicted metal-binding protein [Function unknown]; Region: COG5469 63737013633 Uncharacterized conserved protein [Function unknown]; Region: COG4095 63737013634 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 63737013635 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 63737013636 B12 binding site [chemical binding]; other site 63737013637 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 63737013638 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 63737013639 putative hydrophobic ligand binding site [chemical binding]; other site 63737013640 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 63737013641 classical (c) SDRs; Region: SDR_c; cd05233 63737013642 NAD(P) binding site [chemical binding]; other site 63737013643 active site 63737013644 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 63737013645 putative di-iron ligands [ion binding]; other site 63737013646 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 63737013647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737013648 FeS/SAM binding site; other site 63737013649 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 63737013650 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 63737013651 HflX GTPase family; Region: HflX; cd01878 63737013652 G1 box; other site 63737013653 GTP/Mg2+ binding site [chemical binding]; other site 63737013654 Switch I region; other site 63737013655 G2 box; other site 63737013656 G3 box; other site 63737013657 Switch II region; other site 63737013658 G4 box; other site 63737013659 G5 box; other site 63737013660 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 63737013661 GSH binding site [chemical binding]; other site 63737013662 catalytic residues [active] 63737013663 glutathione synthetase; Provisional; Region: PRK05246 63737013664 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 63737013665 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 63737013666 cell division protein FtsZ; Validated; Region: PRK09330 63737013667 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 63737013668 nucleotide binding site [chemical binding]; other site 63737013669 SulA interaction site; other site 63737013670 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 63737013671 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 63737013672 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 63737013673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737013674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737013675 Archaeal ATPase; Region: Arch_ATPase; pfam01637 63737013676 Walker A motif; other site 63737013677 ATP binding site [chemical binding]; other site 63737013678 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737013679 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737013680 structural tetrad; other site 63737013681 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737013682 structural tetrad; other site 63737013683 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737013684 WD40 repeats; Region: WD40; smart00320 63737013685 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 63737013686 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 63737013687 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737013688 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737013689 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737013690 DNA binding residues [nucleotide binding] 63737013691 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013692 binding surface 63737013693 TPR repeat; Region: TPR_11; pfam13414 63737013694 TPR motif; other site 63737013695 TPR repeat; Region: TPR_11; pfam13414 63737013696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013697 binding surface 63737013698 TPR motif; other site 63737013699 Uncharacterized conserved protein [Function unknown]; Region: COG0393 63737013700 Protein of unknown function (DUF2492); Region: DUF2492; cl11278 63737013701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737013702 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 63737013703 putative DNA binding site [nucleotide binding]; other site 63737013704 putative Zn2+ binding site [ion binding]; other site 63737013705 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 63737013706 putative ABC transporter; Region: ycf24; CHL00085 63737013707 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 63737013708 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 63737013709 Walker A/P-loop; other site 63737013710 ATP binding site [chemical binding]; other site 63737013711 Q-loop/lid; other site 63737013712 ABC transporter signature motif; other site 63737013713 Walker B; other site 63737013714 D-loop; other site 63737013715 H-loop/switch region; other site 63737013716 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 63737013717 FeS assembly protein SufD; Region: sufD; TIGR01981 63737013718 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 63737013719 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 63737013720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737013721 catalytic residue [active] 63737013722 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737013723 putative active site [active] 63737013724 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737013725 putative active site [active] 63737013726 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737013727 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737013728 P-loop; other site 63737013729 Magnesium ion binding site [ion binding]; other site 63737013730 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737013731 Magnesium ion binding site [ion binding]; other site 63737013732 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737013733 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 63737013734 structural tetrad; other site 63737013735 Predicted membrane protein [Function unknown]; Region: COG1470 63737013736 Methyltransferase domain; Region: Methyltransf_11; pfam08241 63737013737 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 63737013738 Heme NO binding associated; Region: HNOBA; pfam07701 63737013739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737013740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737013741 dimer interface [polypeptide binding]; other site 63737013742 phosphorylation site [posttranslational modification] 63737013743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737013744 ATP binding site [chemical binding]; other site 63737013745 Mg2+ binding site [ion binding]; other site 63737013746 G-X-G motif; other site 63737013747 Heme NO binding; Region: HNOB; pfam07700 63737013748 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 63737013749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737013750 S-adenosylmethionine binding site [chemical binding]; other site 63737013751 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 63737013752 Phycobilisome protein; Region: Phycobilisome; cl08227 63737013753 Phycobilisome protein; Region: Phycobilisome; cl08227 63737013754 phycobillisome linker protein; Region: apcE; CHL00091 63737013755 Phycobilisome protein; Region: Phycobilisome; cl08227 63737013756 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737013757 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737013758 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737013759 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737013760 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737013761 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 63737013762 Ligand binding site; other site 63737013763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737013764 active site 63737013765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737013766 active site 63737013767 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 63737013768 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 63737013769 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737013770 Chain length determinant protein; Region: Wzz; pfam02706 63737013771 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 63737013772 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737013773 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 63737013774 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737013775 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 63737013776 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 63737013777 NAD binding site [chemical binding]; other site 63737013778 homodimer interface [polypeptide binding]; other site 63737013779 active site 63737013780 substrate binding site [chemical binding]; other site 63737013781 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 63737013782 XisI protein; Region: XisI; pfam08869 63737013783 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737013784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737013785 S-adenosylmethionine binding site [chemical binding]; other site 63737013786 ATP synthase I chain; Region: ATP_synt_I; pfam03899 63737013787 ATP synthase CF0 A subunit; Region: atpI; CHL00046 63737013788 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 63737013789 ATP synthase CF0 C subunit; Region: atpH; CHL00061 63737013790 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 63737013791 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 63737013792 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 63737013793 ATP synthase CF0 B subunit; Region: atpF; CHL00019 63737013794 ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145 63737013795 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 63737013796 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 63737013797 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 63737013798 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 63737013799 beta subunit interaction interface [polypeptide binding]; other site 63737013800 Walker A motif; other site 63737013801 ATP binding site [chemical binding]; other site 63737013802 Walker B motif; other site 63737013803 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 63737013804 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 63737013805 core domain interface [polypeptide binding]; other site 63737013806 delta subunit interface [polypeptide binding]; other site 63737013807 epsilon subunit interface [polypeptide binding]; other site 63737013808 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 63737013809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737013810 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 63737013811 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 63737013812 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737013813 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 63737013814 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 63737013815 TIGR03032 family protein; Region: TIGR03032 63737013816 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737013817 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737013818 VCBS repeat; Region: VCBS_repeat; TIGR01965 63737013819 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737013820 FG-GAP repeat; Region: FG-GAP; cl15299 63737013821 FG-GAP repeat; Region: FG-GAP; cl15299 63737013822 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737013823 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 63737013824 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 63737013825 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 63737013826 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 63737013827 active site 63737013828 PHP Thumb interface [polypeptide binding]; other site 63737013829 metal binding site [ion binding]; metal-binding site 63737013830 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 63737013831 protein-splicing catalytic site; other site 63737013832 thioester formation/cholesterol transfer; other site 63737013833 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 63737013834 propionate/acetate kinase; Provisional; Region: PRK12379 63737013835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737013836 Coenzyme A binding pocket [chemical binding]; other site 63737013837 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 63737013838 homodimer interface [polypeptide binding]; other site 63737013839 substrate-cofactor binding pocket; other site 63737013840 Aminotransferase class IV; Region: Aminotran_4; pfam01063 63737013841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737013842 catalytic residue [active] 63737013843 FtsH Extracellular; Region: FtsH_ext; pfam06480 63737013844 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 63737013845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737013846 Walker A motif; other site 63737013847 ATP binding site [chemical binding]; other site 63737013848 Walker B motif; other site 63737013849 arginine finger; other site 63737013850 Peptidase family M41; Region: Peptidase_M41; pfam01434 63737013851 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 63737013852 CHAT domain; Region: CHAT; pfam12770 63737013853 flagellar capping protein; Reviewed; Region: fliD; PRK08032 63737013854 MoxR-like ATPases [General function prediction only]; Region: COG0714 63737013855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737013856 Walker A motif; other site 63737013857 ATP binding site [chemical binding]; other site 63737013858 Walker B motif; other site 63737013859 arginine finger; other site 63737013860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 63737013861 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737013862 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737013863 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737013864 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737013865 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 63737013866 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 63737013867 putative active site [active] 63737013868 putative NTP binding site [chemical binding]; other site 63737013869 putative nucleic acid binding site [nucleotide binding]; other site 63737013870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 63737013871 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 63737013872 active site 63737013873 metal binding site [ion binding]; metal-binding site 63737013874 interdomain interaction site; other site 63737013875 D5 N terminal like; Region: D5_N; smart00885 63737013876 Phage associated DNA primase [General function prediction only]; Region: COG3378 63737013877 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 63737013878 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 63737013879 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 63737013880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737013881 ATP binding site [chemical binding]; other site 63737013882 putative Mg++ binding site [ion binding]; other site 63737013883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737013884 nucleotide binding region [chemical binding]; other site 63737013885 ATP-binding site [chemical binding]; other site 63737013886 HsdM N-terminal domain; Region: HsdM_N; pfam12161 63737013887 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 63737013888 Methyltransferase domain; Region: Methyltransf_26; pfam13659 63737013889 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 63737013890 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 63737013891 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 63737013892 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 63737013893 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 63737013894 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 63737013895 catalytic residues [active] 63737013896 catalytic nucleophile [active] 63737013897 Presynaptic Site I dimer interface [polypeptide binding]; other site 63737013898 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 63737013899 Synaptic Flat tetramer interface [polypeptide binding]; other site 63737013900 Synaptic Site I dimer interface [polypeptide binding]; other site 63737013901 DNA binding site [nucleotide binding] 63737013902 Recombinase; Region: Recombinase; pfam07508 63737013903 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 63737013904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 63737013905 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 63737013906 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737013907 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737013908 active site 63737013909 catalytic residues [active] 63737013910 DNA binding site [nucleotide binding] 63737013911 Int/Topo IB signature motif; other site 63737013912 Sporulation and spore germination; Region: Germane; cl11253 63737013913 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 63737013914 active site 63737013915 ribulose/triose binding site [chemical binding]; other site 63737013916 phosphate binding site [ion binding]; other site 63737013917 substrate (anthranilate) binding pocket [chemical binding]; other site 63737013918 product (indole) binding pocket [chemical binding]; other site 63737013919 Response regulator receiver domain; Region: Response_reg; pfam00072 63737013920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737013921 active site 63737013922 phosphorylation site [posttranslational modification] 63737013923 intermolecular recognition site; other site 63737013924 dimerization interface [polypeptide binding]; other site 63737013925 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 63737013926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737013927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737013928 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 63737013929 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 63737013930 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 63737013931 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 63737013932 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 63737013933 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 63737013934 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 63737013935 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 63737013936 dihydrodipicolinate reductase; Provisional; Region: PRK00048 63737013937 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 63737013938 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 63737013939 Right handed beta helix region; Region: Beta_helix; pfam13229 63737013940 precorrin-8X methylmutase; Validated; Region: PRK05953 63737013941 Precorrin-8X methylmutase; Region: CbiC; pfam02570 63737013942 Repair protein; Region: Repair_PSII; pfam04536 63737013943 Predicted membrane protein [Function unknown]; Region: COG4042 63737013944 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 63737013945 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 63737013946 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 63737013947 intersubunit interface [polypeptide binding]; other site 63737013948 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 63737013949 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 63737013950 Peptidase family M48; Region: Peptidase_M48; pfam01435 63737013951 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 63737013952 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 63737013953 active site 63737013954 metal binding site [ion binding]; metal-binding site 63737013955 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 63737013956 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 63737013957 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 63737013958 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 63737013959 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 63737013960 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 63737013961 active site 63737013962 tyramine oxidase; Provisional; Region: tynA; PRK11504 63737013963 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 63737013964 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 63737013965 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 63737013966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737013967 binding surface 63737013968 TPR repeat; Region: TPR_11; pfam13414 63737013969 TPR motif; other site 63737013970 TPR repeat; Region: TPR_11; pfam13414 63737013971 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 63737013972 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737013973 substrate binding pocket [chemical binding]; other site 63737013974 membrane-bound complex binding site; other site 63737013975 hinge residues; other site 63737013976 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 63737013977 23S rRNA binding site [nucleotide binding]; other site 63737013978 L21 binding site [polypeptide binding]; other site 63737013979 L13 binding site [polypeptide binding]; other site 63737013980 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 63737013981 Exoribonuclease R [Transcription]; Region: VacB; COG0557 63737013982 RNB domain; Region: RNB; pfam00773 63737013983 ribosomal protein S18; Region: rps18; CHL00077 63737013984 ribosomal protein L33; Region: rpl33; CHL00104 63737013985 RDD family; Region: RDD; pfam06271 63737013986 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 63737013987 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 63737013988 dimer interface [polypeptide binding]; other site 63737013989 putative functional site; other site 63737013990 putative MPT binding site; other site 63737013991 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 63737013992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 63737013993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737013994 catalytic residue [active] 63737013995 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 63737013996 FOG: CBS domain [General function prediction only]; Region: COG0517 63737013997 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620 63737013998 PAS fold; Region: PAS; pfam00989 63737013999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014000 putative active site [active] 63737014001 heme pocket [chemical binding]; other site 63737014002 PAS domain S-box; Region: sensory_box; TIGR00229 63737014003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014004 putative active site [active] 63737014005 heme pocket [chemical binding]; other site 63737014006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014007 PAS fold; Region: PAS_3; pfam08447 63737014008 putative active site [active] 63737014009 heme pocket [chemical binding]; other site 63737014010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014011 PAS fold; Region: PAS_3; pfam08447 63737014012 putative active site [active] 63737014013 heme pocket [chemical binding]; other site 63737014014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014015 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737014016 putative active site [active] 63737014017 heme pocket [chemical binding]; other site 63737014018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014019 dimer interface [polypeptide binding]; other site 63737014020 phosphorylation site [posttranslational modification] 63737014021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014022 ATP binding site [chemical binding]; other site 63737014023 Mg2+ binding site [ion binding]; other site 63737014024 G-X-G motif; other site 63737014025 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014027 active site 63737014028 phosphorylation site [posttranslational modification] 63737014029 intermolecular recognition site; other site 63737014030 dimerization interface [polypeptide binding]; other site 63737014031 Putative phosphatase (DUF442); Region: DUF442; cl17385 63737014032 sucrose synthase; Region: sucr_synth; TIGR02470 63737014033 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 63737014034 putative ADP-binding pocket [chemical binding]; other site 63737014035 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 63737014036 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 63737014037 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 63737014038 beta-phosphoglucomutase; Region: bPGM; TIGR01990 63737014039 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 63737014040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737014041 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737014042 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014043 putative active site [active] 63737014044 heme pocket [chemical binding]; other site 63737014045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014046 dimer interface [polypeptide binding]; other site 63737014047 phosphorylation site [posttranslational modification] 63737014048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014049 ATP binding site [chemical binding]; other site 63737014050 Mg2+ binding site [ion binding]; other site 63737014051 G-X-G motif; other site 63737014052 Predicted transcriptional regulator [Transcription]; Region: COG1959 63737014053 Transcriptional regulator; Region: Rrf2; pfam02082 63737014054 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737014055 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014056 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014057 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 63737014058 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 63737014059 acetylornithine aminotransferase; Provisional; Region: PRK02627 63737014060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737014061 inhibitor-cofactor binding pocket; inhibition site 63737014062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737014063 catalytic residue [active] 63737014064 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 63737014065 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 63737014066 Ion channel; Region: Ion_trans_2; pfam07885 63737014067 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 63737014068 TrkA-N domain; Region: TrkA_N; pfam02254 63737014069 TrkA-C domain; Region: TrkA_C; pfam02080 63737014070 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737014071 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737014072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737014073 S-adenosylmethionine binding site [chemical binding]; other site 63737014074 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 63737014075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737014076 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 63737014077 dimerization interface [polypeptide binding]; other site 63737014078 substrate binding pocket [chemical binding]; other site 63737014079 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 63737014080 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 63737014081 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 63737014082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737014083 S-adenosylmethionine binding site [chemical binding]; other site 63737014084 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 63737014085 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 63737014086 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737014087 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014088 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737014089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737014090 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 63737014091 Uncharacterized conserved protein [Function unknown]; Region: COG1565 63737014092 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 63737014093 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 63737014094 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 63737014095 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 63737014096 dimerization interface [polypeptide binding]; other site 63737014097 domain crossover interface; other site 63737014098 redox-dependent activation switch; other site 63737014099 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737014100 Ligand Binding Site [chemical binding]; other site 63737014101 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 63737014102 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 63737014103 NAD binding site [chemical binding]; other site 63737014104 dimerization interface [polypeptide binding]; other site 63737014105 product binding site; other site 63737014106 substrate binding site [chemical binding]; other site 63737014107 zinc binding site [ion binding]; other site 63737014108 catalytic residues [active] 63737014109 ribosomal protein S20; Region: rps20; CHL00102 63737014110 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 63737014111 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 63737014112 active site 63737014113 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 63737014114 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 63737014115 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 63737014116 RPB1 interaction site [polypeptide binding]; other site 63737014117 RPB10 interaction site [polypeptide binding]; other site 63737014118 RPB11 interaction site [polypeptide binding]; other site 63737014119 RPB3 interaction site [polypeptide binding]; other site 63737014120 RPB12 interaction site [polypeptide binding]; other site 63737014121 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 63737014122 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 63737014123 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 63737014124 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 63737014125 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 63737014126 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 63737014127 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 63737014128 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 63737014129 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 63737014130 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 63737014131 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 63737014132 DNA binding site [nucleotide binding] 63737014133 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 63737014134 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737014135 putative active site [active] 63737014136 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 63737014137 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 63737014138 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 63737014139 putative active site [active] 63737014140 oxyanion strand; other site 63737014141 catalytic triad [active] 63737014142 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 63737014143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737014144 S-adenosylmethionine binding site [chemical binding]; other site 63737014145 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 63737014146 Cytochrome c; Region: Cytochrom_C; pfam00034 63737014147 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737014148 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737014149 ligand binding site [chemical binding]; other site 63737014150 flexible hinge region; other site 63737014151 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 63737014152 Amidase; Region: Amidase; pfam01425 63737014153 methionine aminopeptidase; Provisional; Region: PRK08671 63737014154 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 63737014155 active site 63737014156 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 63737014157 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737014158 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737014159 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737014160 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737014161 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737014162 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737014163 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737014164 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737014165 active site 63737014166 metal binding site [ion binding]; metal-binding site 63737014167 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 63737014168 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 63737014169 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 63737014170 trimer interface [polypeptide binding]; other site 63737014171 putative metal binding site [ion binding]; other site 63737014172 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 63737014173 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 63737014174 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 63737014175 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 63737014176 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 63737014177 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 63737014178 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 63737014179 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 63737014180 AMIN domain; Region: AMIN; pfam11741 63737014181 Secretin and TonB N terminus short domain; Region: STN; pfam07660 63737014182 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 63737014183 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 63737014184 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 63737014185 IHF dimer interface [polypeptide binding]; other site 63737014186 IHF - DNA interface [nucleotide binding]; other site 63737014187 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 63737014188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737014189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737014190 homodimer interface [polypeptide binding]; other site 63737014191 catalytic residue [active] 63737014192 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 63737014193 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737014194 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737014195 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 63737014196 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014198 active site 63737014199 phosphorylation site [posttranslational modification] 63737014200 dimerization interface [polypeptide binding]; other site 63737014201 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 63737014202 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737014203 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014204 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014205 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 63737014206 metal binding site 2 [ion binding]; metal-binding site 63737014207 putative DNA binding helix; other site 63737014208 metal binding site 1 [ion binding]; metal-binding site 63737014209 dimer interface [polypeptide binding]; other site 63737014210 structural Zn2+ binding site [ion binding]; other site 63737014211 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 63737014212 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 63737014213 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 63737014214 putative active site [active] 63737014215 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 63737014216 substrate binding site; other site 63737014217 dimer interface; other site 63737014218 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 63737014219 Protein of unknown function (DUF760); Region: DUF760; pfam05542 63737014220 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737014221 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737014222 protein binding site [polypeptide binding]; other site 63737014223 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 63737014224 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 63737014225 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737014226 Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335 63737014227 catalytic triad [active] 63737014228 conserved cis-peptide bond; other site 63737014229 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 63737014230 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737014231 catalytic loop [active] 63737014232 iron binding site [ion binding]; other site 63737014233 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 63737014234 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 63737014235 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 63737014236 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 63737014237 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 63737014238 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 63737014239 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 63737014240 intracellular protease, PfpI family; Region: PfpI; TIGR01382 63737014241 proposed catalytic triad [active] 63737014242 conserved cys residue [active] 63737014243 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 63737014244 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737014245 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737014246 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 63737014247 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 63737014248 XdhC Rossmann domain; Region: XdhC_C; pfam13478 63737014249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737014250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014251 active site 63737014252 phosphorylation site [posttranslational modification] 63737014253 intermolecular recognition site; other site 63737014254 dimerization interface [polypeptide binding]; other site 63737014255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737014256 DNA binding site [nucleotide binding] 63737014257 Hpt domain; Region: Hpt; pfam01627 63737014258 putative binding surface; other site 63737014259 active site 63737014260 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 63737014262 active site 63737014263 phosphorylation site [posttranslational modification] 63737014264 dimerization interface [polypeptide binding]; other site 63737014265 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014267 active site 63737014268 phosphorylation site [posttranslational modification] 63737014269 intermolecular recognition site; other site 63737014270 dimerization interface [polypeptide binding]; other site 63737014271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737014272 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737014273 metal binding site [ion binding]; metal-binding site 63737014274 active site 63737014275 I-site; other site 63737014276 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737014277 PAS fold; Region: PAS_7; pfam12860 63737014278 PAS domain S-box; Region: sensory_box; TIGR00229 63737014279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014280 putative active site [active] 63737014281 heme pocket [chemical binding]; other site 63737014282 PAS domain S-box; Region: sensory_box; TIGR00229 63737014283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014284 putative active site [active] 63737014285 heme pocket [chemical binding]; other site 63737014286 PAS domain S-box; Region: sensory_box; TIGR00229 63737014287 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014288 putative active site [active] 63737014289 heme pocket [chemical binding]; other site 63737014290 PAS domain S-box; Region: sensory_box; TIGR00229 63737014291 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014292 putative active site [active] 63737014293 heme pocket [chemical binding]; other site 63737014294 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014295 GAF domain; Region: GAF_3; pfam13492 63737014296 PAS domain S-box; Region: sensory_box; TIGR00229 63737014297 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014298 putative active site [active] 63737014299 heme pocket [chemical binding]; other site 63737014300 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014301 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737014302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014303 dimer interface [polypeptide binding]; other site 63737014304 phosphorylation site [posttranslational modification] 63737014305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014306 ATP binding site [chemical binding]; other site 63737014307 Mg2+ binding site [ion binding]; other site 63737014308 G-X-G motif; other site 63737014309 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737014310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014311 active site 63737014312 phosphorylation site [posttranslational modification] 63737014313 intermolecular recognition site; other site 63737014314 dimerization interface [polypeptide binding]; other site 63737014315 Cupin domain; Region: Cupin_2; pfam07883 63737014316 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014318 active site 63737014319 phosphorylation site [posttranslational modification] 63737014320 intermolecular recognition site; other site 63737014321 dimerization interface [polypeptide binding]; other site 63737014322 PAS domain S-box; Region: sensory_box; TIGR00229 63737014323 PAS domain; Region: PAS_8; pfam13188 63737014324 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014325 putative active site [active] 63737014326 heme pocket [chemical binding]; other site 63737014327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014328 dimer interface [polypeptide binding]; other site 63737014329 phosphorylation site [posttranslational modification] 63737014330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014331 ATP binding site [chemical binding]; other site 63737014332 Mg2+ binding site [ion binding]; other site 63737014333 G-X-G motif; other site 63737014334 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014336 active site 63737014337 phosphorylation site [posttranslational modification] 63737014338 intermolecular recognition site; other site 63737014339 dimerization interface [polypeptide binding]; other site 63737014340 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 63737014341 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 63737014342 active site 63737014343 zinc binding site [ion binding]; other site 63737014344 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 63737014345 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 63737014346 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737014347 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 63737014348 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 63737014349 putative active site [active] 63737014350 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737014351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737014352 Walker A/P-loop; other site 63737014353 ATP binding site [chemical binding]; other site 63737014354 Q-loop/lid; other site 63737014355 ABC transporter signature motif; other site 63737014356 Walker B; other site 63737014357 D-loop; other site 63737014358 H-loop/switch region; other site 63737014359 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737014360 cofactor binding site; other site 63737014361 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 63737014362 ligand binding site [chemical binding]; other site 63737014363 flexible hinge region; other site 63737014364 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 63737014365 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737014366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737014367 Walker A/P-loop; other site 63737014368 ATP binding site [chemical binding]; other site 63737014369 Q-loop/lid; other site 63737014370 ABC transporter signature motif; other site 63737014371 Walker B; other site 63737014372 D-loop; other site 63737014373 H-loop/switch region; other site 63737014374 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 63737014375 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 63737014376 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 63737014377 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 63737014378 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 63737014379 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 63737014380 protein binding site [polypeptide binding]; other site 63737014381 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 63737014382 Catalytic dyad [active] 63737014383 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 63737014384 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 63737014385 active site 63737014386 substrate binding site [chemical binding]; other site 63737014387 Mg2+ binding site [ion binding]; other site 63737014388 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 63737014389 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 63737014390 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 63737014391 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 63737014392 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 63737014393 elongation factor G; Reviewed; Region: PRK12740 63737014394 G1 box; other site 63737014395 putative GEF interaction site [polypeptide binding]; other site 63737014396 GTP/Mg2+ binding site [chemical binding]; other site 63737014397 Switch I region; other site 63737014398 G2 box; other site 63737014399 G3 box; other site 63737014400 Switch II region; other site 63737014401 G4 box; other site 63737014402 G5 box; other site 63737014403 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 63737014404 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 63737014405 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 63737014406 TPR repeat; Region: TPR_11; pfam13414 63737014407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737014408 binding surface 63737014409 TPR motif; other site 63737014410 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737014411 binding surface 63737014412 TPR repeat; Region: TPR_11; pfam13414 63737014413 TPR motif; other site 63737014414 TPR repeat; Region: TPR_11; pfam13414 63737014415 Predicted membrane protein [Function unknown]; Region: COG3431 63737014416 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 63737014417 FAD binding site [chemical binding]; other site 63737014418 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 63737014419 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 63737014420 active site 63737014421 HIGH motif; other site 63737014422 dimer interface [polypeptide binding]; other site 63737014423 KMSKS motif; other site 63737014424 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 63737014425 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 63737014426 putative di-iron ligands [ion binding]; other site 63737014427 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737014428 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737014429 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737014430 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737014431 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 63737014432 FtsX-like permease family; Region: FtsX; pfam02687 63737014433 glucokinase; Provisional; Region: glk; PRK00292 63737014434 glucokinase, proteobacterial type; Region: glk; TIGR00749 63737014435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 63737014436 catalytic core [active] 63737014437 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737014438 putative active site [active] 63737014439 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 63737014440 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 63737014441 Walker A/P-loop; other site 63737014442 ATP binding site [chemical binding]; other site 63737014443 Q-loop/lid; other site 63737014444 ABC transporter signature motif; other site 63737014445 Walker B; other site 63737014446 D-loop; other site 63737014447 H-loop/switch region; other site 63737014448 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737014449 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737014450 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 63737014451 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 63737014452 Walker A/P-loop; other site 63737014453 ATP binding site [chemical binding]; other site 63737014454 Q-loop/lid; other site 63737014455 ABC transporter signature motif; other site 63737014456 Walker B; other site 63737014457 D-loop; other site 63737014458 H-loop/switch region; other site 63737014459 choline dehydrogenase; Validated; Region: PRK02106 63737014460 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 63737014461 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 63737014462 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 63737014463 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 63737014464 TM-ABC transporter signature motif; other site 63737014465 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737014466 putative active site [active] 63737014467 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 63737014468 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 63737014469 TM-ABC transporter signature motif; other site 63737014470 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 63737014471 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348 63737014472 putative ligand binding site [chemical binding]; other site 63737014473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 63737014474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737014475 Coenzyme A binding pocket [chemical binding]; other site 63737014476 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 63737014477 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 63737014478 putative acyl-acceptor binding pocket; other site 63737014479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737014480 non-specific DNA binding site [nucleotide binding]; other site 63737014481 salt bridge; other site 63737014482 sequence-specific DNA binding site [nucleotide binding]; other site 63737014483 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 63737014484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014485 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737014486 putative active site [active] 63737014487 heme pocket [chemical binding]; other site 63737014488 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014489 putative active site [active] 63737014490 heme pocket [chemical binding]; other site 63737014491 PAS domain S-box; Region: sensory_box; TIGR00229 63737014492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014493 putative active site [active] 63737014494 heme pocket [chemical binding]; other site 63737014495 PAS fold; Region: PAS_4; pfam08448 63737014496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014497 putative active site [active] 63737014498 heme pocket [chemical binding]; other site 63737014499 GAF domain; Region: GAF; pfam01590 63737014500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737014501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014502 dimer interface [polypeptide binding]; other site 63737014503 phosphorylation site [posttranslational modification] 63737014504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014505 ATP binding site [chemical binding]; other site 63737014506 Mg2+ binding site [ion binding]; other site 63737014507 G-X-G motif; other site 63737014508 Response regulator receiver domain; Region: Response_reg; pfam00072 63737014509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014510 active site 63737014511 phosphorylation site [posttranslational modification] 63737014512 intermolecular recognition site; other site 63737014513 dimerization interface [polypeptide binding]; other site 63737014514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737014515 dimerization interface [polypeptide binding]; other site 63737014516 putative DNA binding site [nucleotide binding]; other site 63737014517 putative Zn2+ binding site [ion binding]; other site 63737014518 aspartate aminotransferase; Provisional; Region: PRK05942 63737014519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737014520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737014521 homodimer interface [polypeptide binding]; other site 63737014522 catalytic residue [active] 63737014523 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 63737014524 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 63737014525 putative active site [active] 63737014526 metal binding site [ion binding]; metal-binding site 63737014527 Protein of function (DUF2518); Region: DUF2518; pfam10726 63737014528 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 63737014529 O-Antigen ligase; Region: Wzy_C; pfam04932 63737014530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 63737014531 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 63737014532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737014533 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 63737014534 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737014535 active site 63737014536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737014537 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 63737014538 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737014539 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737014540 Double zinc ribbon; Region: DZR; pfam12773 63737014541 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737014542 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737014543 active site 63737014544 substrate binding site [chemical binding]; other site 63737014545 ATP binding site [chemical binding]; other site 63737014546 activation loop (A-loop); other site 63737014547 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 63737014548 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 63737014549 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 63737014550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737014551 Walker A/P-loop; other site 63737014552 ATP binding site [chemical binding]; other site 63737014553 Q-loop/lid; other site 63737014554 ABC transporter signature motif; other site 63737014555 Walker B; other site 63737014556 D-loop; other site 63737014557 H-loop/switch region; other site 63737014558 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 63737014559 ABC1 family; Region: ABC1; cl17513 63737014560 Haemolytic domain; Region: Haemolytic; cl00506 63737014561 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 63737014562 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 63737014563 Substrate binding site; other site 63737014564 Cupin domain; Region: Cupin_2; cl17218 63737014565 Transcriptional regulator [Transcription]; Region: LytR; COG1316 63737014566 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 63737014567 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737014568 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014570 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014571 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737014572 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014573 GAF domain; Region: GAF; pfam01590 63737014574 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014575 GAF domain; Region: GAF; pfam01590 63737014576 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014577 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737014578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737014579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014580 dimer interface [polypeptide binding]; other site 63737014581 phosphorylation site [posttranslational modification] 63737014582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014583 ATP binding site [chemical binding]; other site 63737014584 Mg2+ binding site [ion binding]; other site 63737014585 G-X-G motif; other site 63737014586 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 63737014587 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 63737014588 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 63737014589 OstA-like protein; Region: OstA; cl00844 63737014590 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 63737014591 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 63737014592 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 63737014593 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 63737014594 trimer interface [polypeptide binding]; other site 63737014595 active site 63737014596 substrate binding site [chemical binding]; other site 63737014597 CoA binding site [chemical binding]; other site 63737014598 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 63737014599 putative homodimer interface [polypeptide binding]; other site 63737014600 putative active site pocket [active] 63737014601 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 63737014602 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737014603 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737014604 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 63737014605 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737014606 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 63737014607 putative ADP-binding pocket [chemical binding]; other site 63737014608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 63737014609 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737014610 Walker A/P-loop; other site 63737014611 ATP binding site [chemical binding]; other site 63737014612 Q-loop/lid; other site 63737014613 ABC transporter signature motif; other site 63737014614 Walker B; other site 63737014615 D-loop; other site 63737014616 H-loop/switch region; other site 63737014617 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 63737014618 epoxyqueuosine reductase; Region: TIGR00276 63737014619 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 63737014620 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737014621 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737014622 motif II; other site 63737014623 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 63737014624 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 63737014625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014626 ATP binding site [chemical binding]; other site 63737014627 Mg2+ binding site [ion binding]; other site 63737014628 G-X-G motif; other site 63737014629 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737014630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014631 active site 63737014632 phosphorylation site [posttranslational modification] 63737014633 intermolecular recognition site; other site 63737014634 dimerization interface [polypeptide binding]; other site 63737014635 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014636 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737014637 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 63737014638 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 63737014639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737014640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737014641 active site 63737014642 phosphorylation site [posttranslational modification] 63737014643 intermolecular recognition site; other site 63737014644 dimerization interface [polypeptide binding]; other site 63737014645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737014646 DNA binding residues [nucleotide binding] 63737014647 dimerization interface [polypeptide binding]; other site 63737014648 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 63737014649 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 63737014650 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 63737014651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737014652 Walker A/P-loop; other site 63737014653 ATP binding site [chemical binding]; other site 63737014654 Q-loop/lid; other site 63737014655 ABC transporter signature motif; other site 63737014656 Walker B; other site 63737014657 D-loop; other site 63737014658 H-loop/switch region; other site 63737014659 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737014660 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737014661 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 63737014662 catalytic site [active] 63737014663 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 63737014664 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737014665 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014666 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737014667 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 63737014668 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 63737014669 light-harvesting-like protein 3; Provisional; Region: PLN00014 63737014670 anthranilate synthase component I; Provisional; Region: PRK13565 63737014671 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 63737014672 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 63737014673 PsaD; Region: PsaD; pfam02531 63737014674 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 63737014675 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737014676 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737014677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014678 dimer interface [polypeptide binding]; other site 63737014679 phosphorylation site [posttranslational modification] 63737014680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014681 ATP binding site [chemical binding]; other site 63737014682 Mg2+ binding site [ion binding]; other site 63737014683 G-X-G motif; other site 63737014684 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 63737014685 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 63737014686 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 63737014687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737014688 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737014689 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737014690 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737014691 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 63737014692 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 63737014693 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 63737014694 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 63737014695 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 63737014696 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 63737014697 dimer interface [polypeptide binding]; other site 63737014698 active site 63737014699 glycine-pyridoxal phosphate binding site [chemical binding]; other site 63737014700 folate binding site [chemical binding]; other site 63737014701 competence damage-inducible protein A; Provisional; Region: PRK00549 63737014702 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 63737014703 putative MPT binding site; other site 63737014704 Competence-damaged protein; Region: CinA; pfam02464 63737014705 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 63737014706 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 63737014707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737014708 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 63737014709 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 63737014710 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737014711 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 63737014712 NAD binding site [chemical binding]; other site 63737014713 putative substrate binding site 2 [chemical binding]; other site 63737014714 putative substrate binding site 1 [chemical binding]; other site 63737014715 active site 63737014716 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 63737014717 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 63737014718 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 63737014719 Ligand Binding Site [chemical binding]; other site 63737014720 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737014721 Ligand Binding Site [chemical binding]; other site 63737014722 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 63737014723 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 63737014724 Domain of unknown function DUF59; Region: DUF59; pfam01883 63737014725 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 63737014726 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 63737014727 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 63737014728 hydrophobic ligand binding site; other site 63737014729 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 63737014730 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 63737014731 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737014732 anti sigma factor interaction site; other site 63737014733 regulatory phosphorylation site [posttranslational modification]; other site 63737014734 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 63737014735 Thf1-like protein; Reviewed; Region: PRK13266 63737014736 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 63737014737 Predicted membrane protein [Function unknown]; Region: COG1950 63737014738 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 63737014739 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 63737014740 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 63737014741 Uncharacterized conserved protein [Function unknown]; Region: COG3339 63737014742 GxxExxY protein; Region: GxxExxY; TIGR04256 63737014743 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 63737014744 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 63737014745 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 63737014746 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 63737014747 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 63737014748 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 63737014749 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 63737014750 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 63737014751 MgtE intracellular N domain; Region: MgtE_N; smart00924 63737014752 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 63737014753 Divalent cation transporter; Region: MgtE; pfam01769 63737014754 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 63737014755 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 63737014756 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 63737014757 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 63737014758 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 63737014759 CoA-ligase; Region: Ligase_CoA; pfam00549 63737014760 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 63737014761 CoA binding domain; Region: CoA_binding; smart00881 63737014762 CoA-ligase; Region: Ligase_CoA; pfam00549 63737014763 Ecdysteroid kinase; Region: EcKinase; cl17738 63737014764 Phosphotransferase enzyme family; Region: APH; pfam01636 63737014765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 63737014766 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 63737014767 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 63737014768 RibD C-terminal domain; Region: RibD_C; cl17279 63737014769 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 63737014770 protein I interface; other site 63737014771 D2 interface; other site 63737014772 protein T interface; other site 63737014773 chlorophyll binding site; other site 63737014774 beta carotene binding site; other site 63737014775 pheophytin binding site; other site 63737014776 manganese-stabilizing polypeptide interface; other site 63737014777 CP43 interface; other site 63737014778 protein L interface; other site 63737014779 oxygen evolving complex binding site; other site 63737014780 bromide binding site; other site 63737014781 quinone binding site; other site 63737014782 Fe binding site [ion binding]; other site 63737014783 core light harvesting interface; other site 63737014784 cytochrome b559 alpha subunit interface; other site 63737014785 cytochrome c-550 interface; other site 63737014786 protein J interface; other site 63737014787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014788 dimer interface [polypeptide binding]; other site 63737014789 phosphorylation site [posttranslational modification] 63737014790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014791 ATP binding site [chemical binding]; other site 63737014792 Mg2+ binding site [ion binding]; other site 63737014793 G-X-G motif; other site 63737014794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737014795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737014796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737014797 binding surface 63737014798 TPR motif; other site 63737014799 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737014800 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 63737014801 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 63737014802 active site 63737014803 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737014804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737014805 TPR motif; other site 63737014806 binding surface 63737014807 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737014808 CHAT domain; Region: CHAT; pfam12770 63737014809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737014810 non-specific DNA binding site [nucleotide binding]; other site 63737014811 salt bridge; other site 63737014812 sequence-specific DNA binding site [nucleotide binding]; other site 63737014813 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 63737014814 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 63737014815 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 63737014816 dimer interface [polypeptide binding]; other site 63737014817 putative anticodon binding site; other site 63737014818 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 63737014819 motif 1; other site 63737014820 active site 63737014821 motif 2; other site 63737014822 motif 3; other site 63737014823 KTSC domain; Region: KTSC; pfam13619 63737014824 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 63737014825 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 63737014826 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 63737014827 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 63737014828 Predicted kinase [General function prediction only]; Region: COG4240 63737014829 Protein of unknown function (DUF565); Region: DUF565; pfam04483 63737014830 photosystem I subunit VII; Region: psaC; CHL00065 63737014831 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 63737014832 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 63737014833 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 63737014834 glutaminase active site [active] 63737014835 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 63737014836 dimer interface [polypeptide binding]; other site 63737014837 active site 63737014838 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 63737014839 dimer interface [polypeptide binding]; other site 63737014840 active site 63737014841 AIPR protein; Region: AIPR; pfam10592 63737014842 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 63737014843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737014844 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 63737014845 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 63737014846 ligand binding site [chemical binding]; other site 63737014847 NAD binding site [chemical binding]; other site 63737014848 dimerization interface [polypeptide binding]; other site 63737014849 catalytic site [active] 63737014850 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 63737014851 putative L-serine binding site [chemical binding]; other site 63737014852 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737014853 putative active site [active] 63737014854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737014855 PAS domain; Region: PAS_9; pfam13426 63737014856 putative active site [active] 63737014857 heme pocket [chemical binding]; other site 63737014858 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737014859 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737014860 metal binding site [ion binding]; metal-binding site 63737014861 active site 63737014862 I-site; other site 63737014863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737014864 S-adenosylmethionine binding site [chemical binding]; other site 63737014865 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 63737014866 nucleotide binding site/active site [active] 63737014867 HIT family signature motif; other site 63737014868 catalytic residue [active] 63737014869 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 63737014870 Homeodomain-like domain; Region: HTH_23; pfam13384 63737014871 Winged helix-turn helix; Region: HTH_29; pfam13551 63737014872 Homeodomain-like domain; Region: HTH_32; pfam13565 63737014873 Winged helix-turn helix; Region: HTH_33; pfam13592 63737014874 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737014875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 63737014876 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 63737014877 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 63737014878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737014879 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 63737014880 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 63737014881 DNA binding site [nucleotide binding] 63737014882 active site 63737014883 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 63737014884 endonuclease III; Region: ENDO3c; smart00478 63737014885 minor groove reading motif; other site 63737014886 helix-hairpin-helix signature motif; other site 63737014887 substrate binding pocket [chemical binding]; other site 63737014888 active site 63737014889 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 63737014890 EamA-like transporter family; Region: EamA; pfam00892 63737014891 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 63737014892 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 63737014893 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 63737014894 bacterial Hfq-like; Region: Hfq; cd01716 63737014895 hexamer interface [polypeptide binding]; other site 63737014896 Sm1 motif; other site 63737014897 RNA binding site [nucleotide binding]; other site 63737014898 Sm2 motif; other site 63737014899 Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198 63737014900 active site 63737014901 metal binding site [ion binding]; metal-binding site 63737014902 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 63737014903 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 63737014904 active site 63737014905 UbiA prenyltransferase family; Region: UbiA; pfam01040 63737014906 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 63737014907 Uncharacterized conserved protein [Function unknown]; Region: COG3379 63737014908 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 63737014909 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 63737014910 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 63737014911 tetramer interface [polypeptide binding]; other site 63737014912 heme binding pocket [chemical binding]; other site 63737014913 NADPH binding site [chemical binding]; other site 63737014914 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 63737014915 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 63737014916 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737014917 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737014918 Predicted membrane protein [Function unknown]; Region: COG1981 63737014919 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 63737014920 Stage II sporulation protein; Region: SpoIID; pfam08486 63737014921 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737014922 Chain length determinant protein; Region: Wzz; pfam02706 63737014923 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 63737014924 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 63737014925 ribonuclease Z; Region: RNase_Z; TIGR02651 63737014926 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 63737014927 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 63737014928 dimerization interface [polypeptide binding]; other site 63737014929 active site 63737014930 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737014931 dimerization interface [polypeptide binding]; other site 63737014932 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737014933 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737014934 dimer interface [polypeptide binding]; other site 63737014935 phosphorylation site [posttranslational modification] 63737014936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737014937 ATP binding site [chemical binding]; other site 63737014938 Mg2+ binding site [ion binding]; other site 63737014939 G-X-G motif; other site 63737014940 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 63737014941 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737014942 membrane-bound complex binding site; other site 63737014943 hinge residues; other site 63737014944 NurA nuclease; Region: NurA; smart00933 63737014945 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 63737014946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 63737014947 active site 63737014948 motif I; other site 63737014949 motif II; other site 63737014950 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 63737014951 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 63737014952 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 63737014953 iron-sulfur cluster [ion binding]; other site 63737014954 [2Fe-2S] cluster binding site [ion binding]; other site 63737014955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737014956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 63737014957 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 63737014958 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 63737014959 G1 box; other site 63737014960 GTP/Mg2+ binding site [chemical binding]; other site 63737014961 Switch I region; other site 63737014962 G2 box; other site 63737014963 Switch II region; other site 63737014964 G3 box; other site 63737014965 G4 box; other site 63737014966 Domain of unknown function (DUF697); Region: DUF697; pfam05128 63737014967 CP12 domain; Region: CP12; pfam02672 63737014968 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 63737014969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 63737014970 RNA binding surface [nucleotide binding]; other site 63737014971 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 63737014972 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 63737014973 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 63737014974 putative active site [active] 63737014975 putative dimer interface [polypeptide binding]; other site 63737014976 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 63737014977 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 63737014978 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 63737014979 active site 63737014980 dimer interface [polypeptide binding]; other site 63737014981 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 63737014982 Peptidase family M50; Region: Peptidase_M50; pfam02163 63737014983 active site 63737014984 putative substrate binding region [chemical binding]; other site 63737014985 FOG: CBS domain [General function prediction only]; Region: COG0517 63737014986 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 63737014987 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 63737014988 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 63737014989 active site residue [active] 63737014990 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 63737014991 active site residue [active] 63737014992 GAF domain; Region: GAF_3; pfam13492 63737014993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737014994 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737014995 DNA binding residues [nucleotide binding] 63737014996 dimerization interface [polypeptide binding]; other site 63737014997 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 63737014998 Leucine carboxyl methyltransferase; Region: LCM; cl01306 63737014999 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737015000 putative active site [active] 63737015001 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 63737015002 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737015003 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737015004 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737015005 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737015006 metal binding site [ion binding]; metal-binding site 63737015007 active site 63737015008 I-site; other site 63737015009 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737015010 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 63737015011 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 63737015012 dinuclear metal binding motif [ion binding]; other site 63737015013 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 63737015014 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 63737015015 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 63737015016 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 63737015017 putative NADP binding site [chemical binding]; other site 63737015018 putative substrate binding site [chemical binding]; other site 63737015019 active site 63737015020 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 63737015021 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737015022 FeS/SAM binding site; other site 63737015023 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 63737015024 Methyltransferase domain; Region: Methyltransf_26; pfam13659 63737015025 Phycobilisome protein; Region: Phycobilisome; cl08227 63737015026 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 63737015027 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737015028 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 63737015029 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 63737015030 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 63737015031 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 63737015032 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 63737015033 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 63737015034 PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130 63737015035 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 63737015036 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 63737015037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 63737015038 Proline dehydrogenase; Region: Pro_dh; pfam01619 63737015039 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 63737015040 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 63737015041 Glutamate binding site [chemical binding]; other site 63737015042 homodimer interface [polypeptide binding]; other site 63737015043 NAD binding site [chemical binding]; other site 63737015044 catalytic residues [active] 63737015045 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 63737015046 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 63737015047 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737015048 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737015049 structural tetrad; other site 63737015050 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737015051 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737015052 structural tetrad; other site 63737015053 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 63737015054 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 63737015055 active site 63737015056 catalytic triad [active] 63737015057 oxyanion hole [active] 63737015058 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 63737015059 dimer interface [polypeptide binding]; other site 63737015060 active site 63737015061 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 63737015062 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 63737015063 PYR/PP interface [polypeptide binding]; other site 63737015064 dimer interface [polypeptide binding]; other site 63737015065 TPP binding site [chemical binding]; other site 63737015066 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 63737015067 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 63737015068 TPP-binding site [chemical binding]; other site 63737015069 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 63737015070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737015071 motif II; other site 63737015072 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 63737015073 MltA specific insert domain; Region: MltA; pfam03562 63737015074 3D domain; Region: 3D; pfam06725 63737015075 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 63737015076 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737015077 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737015078 active site 63737015079 ATP binding site [chemical binding]; other site 63737015080 substrate binding site [chemical binding]; other site 63737015081 activation loop (A-loop); other site 63737015082 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 63737015083 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737015084 dimerization interface [polypeptide binding]; other site 63737015085 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 63737015086 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737015087 membrane-bound complex binding site; other site 63737015088 hinge residues; other site 63737015089 GAF domain; Region: GAF; pfam01590 63737015090 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737015091 GAF domain; Region: GAF; cl17456 63737015092 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737015093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737015094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737015095 dimer interface [polypeptide binding]; other site 63737015096 phosphorylation site [posttranslational modification] 63737015097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015098 ATP binding site [chemical binding]; other site 63737015099 Mg2+ binding site [ion binding]; other site 63737015100 G-X-G motif; other site 63737015101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 63737015102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737015103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737015104 dimerization interface [polypeptide binding]; other site 63737015105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737015106 dimer interface [polypeptide binding]; other site 63737015107 phosphorylation site [posttranslational modification] 63737015108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015109 ATP binding site [chemical binding]; other site 63737015110 Mg2+ binding site [ion binding]; other site 63737015111 G-X-G motif; other site 63737015112 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737015113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015114 active site 63737015115 phosphorylation site [posttranslational modification] 63737015116 intermolecular recognition site; other site 63737015117 dimerization interface [polypeptide binding]; other site 63737015118 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737015119 DNA binding site [nucleotide binding] 63737015120 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 63737015121 S-layer homology domain; Region: SLH; pfam00395 63737015122 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737015123 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 63737015124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737015125 putative substrate translocation pore; other site 63737015126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737015127 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 63737015128 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 63737015129 TM-ABC transporter signature motif; other site 63737015130 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 63737015131 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 63737015132 Walker A/P-loop; other site 63737015133 ATP binding site [chemical binding]; other site 63737015134 Q-loop/lid; other site 63737015135 ABC transporter signature motif; other site 63737015136 Walker B; other site 63737015137 D-loop; other site 63737015138 H-loop/switch region; other site 63737015139 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 63737015140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 63737015141 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 63737015142 putative ligand binding site [chemical binding]; other site 63737015143 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 63737015144 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 63737015145 putative ligand binding site [chemical binding]; other site 63737015146 Family of unknown function (DUF706); Region: DUF706; pfam05153 63737015147 SnoaL-like domain; Region: SnoaL_2; pfam12680 63737015148 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 63737015149 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 63737015150 ATP-binding site [chemical binding]; other site 63737015151 Gluconate-6-phosphate binding site [chemical binding]; other site 63737015152 Shikimate kinase; Region: SKI; pfam01202 63737015153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 63737015154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 63737015155 DNA binding site [nucleotide binding] 63737015156 domain linker motif; other site 63737015157 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 63737015158 dimerization interface [polypeptide binding]; other site 63737015159 ligand binding site [chemical binding]; other site 63737015160 glucuronate isomerase; Reviewed; Region: PRK02925 63737015161 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 63737015162 D-mannonate oxidoreductase; Provisional; Region: PRK08277 63737015163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737015164 NAD(P) binding site [chemical binding]; other site 63737015165 active site 63737015166 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 63737015167 TniQ; Region: TniQ; pfam06527 63737015168 AAA domain; Region: AAA_22; pfam13401 63737015169 Bacterial TniB protein; Region: TniB; pfam05621 63737015170 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737015171 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 63737015172 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 63737015173 Degradation arginine-rich protein for mis-folding; Region: Armet; pfam10208 63737015174 Homeodomain-like domain; Region: HTH_23; cl17451 63737015175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737015176 non-specific DNA binding site [nucleotide binding]; other site 63737015177 salt bridge; other site 63737015178 sequence-specific DNA binding site [nucleotide binding]; other site 63737015179 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 63737015180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737015181 S-adenosylmethionine binding site [chemical binding]; other site 63737015182 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 63737015183 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 63737015184 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 63737015185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 63737015186 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 63737015187 active site 63737015188 putative DNA-binding cleft [nucleotide binding]; other site 63737015189 dimer interface [polypeptide binding]; other site 63737015190 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 63737015191 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 63737015192 phosphate binding site [ion binding]; other site 63737015193 putative substrate binding pocket [chemical binding]; other site 63737015194 dimer interface [polypeptide binding]; other site 63737015195 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 63737015196 similar to hypothetical protein 63737015197 Patatin [General function prediction only]; Region: COG3621 63737015198 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 63737015199 active site 63737015200 nucleophile elbow; other site 63737015201 dihydroorotase; Provisional; Region: PRK07575 63737015202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737015203 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 63737015204 active site 63737015205 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 63737015206 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 63737015207 Catalytic site [active] 63737015208 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 63737015209 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 63737015210 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 63737015211 MOSC domain; Region: MOSC; pfam03473 63737015212 Cache domain; Region: Cache_1; pfam02743 63737015213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737015214 dimerization interface [polypeptide binding]; other site 63737015215 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 63737015216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737015217 dimer interface [polypeptide binding]; other site 63737015218 phosphorylation site [posttranslational modification] 63737015219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015220 ATP binding site [chemical binding]; other site 63737015221 Mg2+ binding site [ion binding]; other site 63737015222 G-X-G motif; other site 63737015223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015224 active site 63737015225 phosphorylation site [posttranslational modification] 63737015226 intermolecular recognition site; other site 63737015227 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737015228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015229 active site 63737015230 dimerization interface [polypeptide binding]; other site 63737015231 Response regulator receiver domain; Region: Response_reg; pfam00072 63737015232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015233 active site 63737015234 phosphorylation site [posttranslational modification] 63737015235 intermolecular recognition site; other site 63737015236 dimerization interface [polypeptide binding]; other site 63737015237 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737015238 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737015239 metal binding site [ion binding]; metal-binding site 63737015240 active site 63737015241 I-site; other site 63737015242 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737015243 Response regulator receiver domain; Region: Response_reg; pfam00072 63737015244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015245 active site 63737015246 phosphorylation site [posttranslational modification] 63737015247 intermolecular recognition site; other site 63737015248 dimerization interface [polypeptide binding]; other site 63737015249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737015250 dimer interface [polypeptide binding]; other site 63737015251 phosphorylation site [posttranslational modification] 63737015252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015253 ATP binding site [chemical binding]; other site 63737015254 Mg2+ binding site [ion binding]; other site 63737015255 G-X-G motif; other site 63737015256 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 63737015257 4Fe-4S binding domain; Region: Fer4; pfam00037 63737015258 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 63737015259 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 63737015260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737015261 Walker A motif; other site 63737015262 ATP binding site [chemical binding]; other site 63737015263 Walker B motif; other site 63737015264 negative regulator GrlR; Provisional; Region: PRK14051 63737015265 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 63737015266 RxxxH motif; other site 63737015267 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737015268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737015269 Walker A/P-loop; other site 63737015270 ATP binding site [chemical binding]; other site 63737015271 Q-loop/lid; other site 63737015272 ABC transporter signature motif; other site 63737015273 Walker B; other site 63737015274 D-loop; other site 63737015275 H-loop/switch region; other site 63737015276 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 63737015277 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 63737015278 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 63737015279 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737015280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737015281 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737015282 TPR repeat; Region: TPR_11; pfam13414 63737015283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015284 binding surface 63737015285 TPR motif; other site 63737015286 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 63737015287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737015288 S-adenosylmethionine binding site [chemical binding]; other site 63737015289 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737015290 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737015291 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737015292 Walker A/P-loop; other site 63737015293 ATP binding site [chemical binding]; other site 63737015294 Q-loop/lid; other site 63737015295 ABC transporter signature motif; other site 63737015296 Walker B; other site 63737015297 D-loop; other site 63737015298 H-loop/switch region; other site 63737015299 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737015300 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737015301 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 63737015302 Walker A/P-loop; other site 63737015303 ATP binding site [chemical binding]; other site 63737015304 Q-loop/lid; other site 63737015305 ABC transporter signature motif; other site 63737015306 Walker B; other site 63737015307 D-loop; other site 63737015308 H-loop/switch region; other site 63737015309 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 63737015310 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 63737015311 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 63737015312 folate binding site [chemical binding]; other site 63737015313 NADP+ binding site [chemical binding]; other site 63737015314 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 63737015315 catalytic residues [active] 63737015316 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 63737015317 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 63737015318 Walker A/P-loop; other site 63737015319 ATP binding site [chemical binding]; other site 63737015320 Q-loop/lid; other site 63737015321 ABC transporter signature motif; other site 63737015322 Walker B; other site 63737015323 D-loop; other site 63737015324 H-loop/switch region; other site 63737015325 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 63737015326 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 63737015327 Walker A/P-loop; other site 63737015328 ATP binding site [chemical binding]; other site 63737015329 Q-loop/lid; other site 63737015330 ABC transporter signature motif; other site 63737015331 Walker B; other site 63737015332 D-loop; other site 63737015333 H-loop/switch region; other site 63737015334 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 63737015335 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737015336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737015337 putative active site [active] 63737015338 heme pocket [chemical binding]; other site 63737015339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737015340 dimer interface [polypeptide binding]; other site 63737015341 phosphorylation site [posttranslational modification] 63737015342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015343 ATP binding site [chemical binding]; other site 63737015344 Mg2+ binding site [ion binding]; other site 63737015345 G-X-G motif; other site 63737015346 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 63737015347 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737015348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737015349 S-adenosylmethionine binding site [chemical binding]; other site 63737015350 glutamine synthetase, type I; Region: GlnA; TIGR00653 63737015351 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 63737015352 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 63737015353 allophycocyanin beta 18 subunit; Region: apcF; CHL00089 63737015354 Z1 domain; Region: Z1; pfam10593 63737015355 XisH protein; Region: XisH; pfam08814 63737015356 XisI protein; Region: XisI; pfam08869 63737015357 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 63737015358 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 63737015359 sulfate transport protein; Provisional; Region: cysT; CHL00187 63737015360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737015361 dimer interface [polypeptide binding]; other site 63737015362 conserved gate region; other site 63737015363 putative PBP binding loops; other site 63737015364 ABC-ATPase subunit interface; other site 63737015365 sulfate transport protein; Provisional; Region: cysT; CHL00187 63737015366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737015367 dimer interface [polypeptide binding]; other site 63737015368 conserved gate region; other site 63737015369 putative PBP binding loops; other site 63737015370 ABC-ATPase subunit interface; other site 63737015371 Winged helix-turn helix; Region: HTH_29; pfam13551 63737015372 Homeodomain-like domain; Region: HTH_23; pfam13384 63737015373 Homeodomain-like domain; Region: HTH_32; pfam13565 63737015374 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737015375 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737015376 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737015377 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737015378 FG-GAP repeat; Region: FG-GAP; pfam01839 63737015379 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 63737015380 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 63737015381 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737015382 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 63737015383 ligand binding site [chemical binding]; other site 63737015384 flexible hinge region; other site 63737015385 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 63737015386 putative switch regulator; other site 63737015387 non-specific DNA interactions [nucleotide binding]; other site 63737015388 DNA binding site [nucleotide binding] 63737015389 sequence specific DNA binding site [nucleotide binding]; other site 63737015390 putative cAMP binding site [chemical binding]; other site 63737015391 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 63737015392 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 63737015393 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 63737015394 trimer interface [polypeptide binding]; other site 63737015395 active site 63737015396 substrate binding site [chemical binding]; other site 63737015397 CoA binding site [chemical binding]; other site 63737015398 Predicted transcriptional regulator [Transcription]; Region: COG1959 63737015399 Transcriptional regulator; Region: Rrf2; pfam02082 63737015400 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 63737015401 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 63737015402 dimer interface [polypeptide binding]; other site 63737015403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737015404 catalytic residue [active] 63737015405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 63737015406 Transposase; Region: DDE_Tnp_ISL3; pfam01610 63737015407 Cadmium resistance transporter; Region: Cad; pfam03596 63737015408 cadmium resistance transporter (or sequestration) family protein; Region: cad; TIGR00779 63737015409 Cadmium resistance transporter; Region: Cad; pfam03596 63737015410 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 63737015411 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737015412 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737015413 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 63737015414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737015415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737015416 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 63737015417 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 63737015418 active site 1 [active] 63737015419 dimer interface [polypeptide binding]; other site 63737015420 hexamer interface [polypeptide binding]; other site 63737015421 active site 2 [active] 63737015422 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 63737015423 active site 63737015424 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 63737015425 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 63737015426 dimer interface [polypeptide binding]; other site 63737015427 motif 1; other site 63737015428 active site 63737015429 motif 2; other site 63737015430 motif 3; other site 63737015431 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 63737015432 anticodon binding site; other site 63737015433 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 63737015434 Predicted membrane protein [Function unknown]; Region: COG1950 63737015435 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 63737015436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 63737015437 catalytic loop [active] 63737015438 iron binding site [ion binding]; other site 63737015439 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 63737015440 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 63737015441 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 63737015442 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 63737015443 RNA binding site [nucleotide binding]; other site 63737015444 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 63737015445 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 63737015446 hypothetical protein; Provisional; Region: PRK07233 63737015447 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737015448 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 63737015449 Ligand binding site; other site 63737015450 Putative Catalytic site; other site 63737015451 DXD motif; other site 63737015452 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 63737015453 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 63737015454 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737015455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737015456 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 63737015457 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 63737015458 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 63737015459 inhibitor-cofactor binding pocket; inhibition site 63737015460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737015461 catalytic residue [active] 63737015462 Protein of unknown function (DUF561); Region: DUF561; pfam04481 63737015463 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737015464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737015465 S-adenosylmethionine binding site [chemical binding]; other site 63737015466 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737015467 putative active site [active] 63737015468 AAA ATPase domain; Region: AAA_16; pfam13191 63737015469 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737015470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015471 TPR motif; other site 63737015472 binding surface 63737015473 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015474 binding surface 63737015475 TPR motif; other site 63737015476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737015477 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 63737015478 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737015479 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737015480 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 63737015481 active site 63737015482 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 63737015483 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 63737015484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737015485 non-specific DNA binding site [nucleotide binding]; other site 63737015486 salt bridge; other site 63737015487 sequence-specific DNA binding site [nucleotide binding]; other site 63737015488 Domain of unknown function (DUF955); Region: DUF955; pfam06114 63737015489 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737015490 putative active site [active] 63737015491 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 63737015492 ATP-sulfurylase; Region: ATPS; cd00517 63737015493 active site 63737015494 HXXH motif; other site 63737015495 flexible loop; other site 63737015496 Caspase domain; Region: Peptidase_C14; pfam00656 63737015497 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015498 binding surface 63737015499 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737015500 TPR motif; other site 63737015501 TPR repeat; Region: TPR_11; pfam13414 63737015502 PRC-barrel domain; Region: PRC; pfam05239 63737015503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 63737015504 PRC-barrel domain; Region: PRC; pfam05239 63737015505 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 63737015506 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 63737015507 Inward rectifier potassium channel; Region: IRK; pfam01007 63737015508 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 63737015509 protein I interface; other site 63737015510 D2 interface; other site 63737015511 protein T interface; other site 63737015512 chlorophyll binding site; other site 63737015513 beta carotene binding site; other site 63737015514 pheophytin binding site; other site 63737015515 manganese-stabilizing polypeptide interface; other site 63737015516 CP43 interface; other site 63737015517 protein L interface; other site 63737015518 oxygen evolving complex binding site; other site 63737015519 bromide binding site; other site 63737015520 quinone binding site; other site 63737015521 Fe binding site [ion binding]; other site 63737015522 core light harvesting interface; other site 63737015523 cytochrome b559 alpha subunit interface; other site 63737015524 cytochrome c-550 interface; other site 63737015525 protein J interface; other site 63737015526 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 63737015527 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 63737015528 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 63737015529 Amidase; Region: Amidase; cl11426 63737015530 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 63737015531 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737015532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737015533 active site 63737015534 catalytic tetrad [active] 63737015535 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 63737015536 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 63737015537 TPP-binding site; other site 63737015538 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 63737015539 PYR/PP interface [polypeptide binding]; other site 63737015540 dimer interface [polypeptide binding]; other site 63737015541 TPP binding site [chemical binding]; other site 63737015542 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 63737015543 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737015544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737015545 PAS fold; Region: PAS_3; pfam08447 63737015546 putative active site [active] 63737015547 heme pocket [chemical binding]; other site 63737015548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737015549 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737015550 putative active site [active] 63737015551 heme pocket [chemical binding]; other site 63737015552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737015553 putative active site [active] 63737015554 heme pocket [chemical binding]; other site 63737015555 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737015556 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737015557 metal binding site [ion binding]; metal-binding site 63737015558 active site 63737015559 I-site; other site 63737015560 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737015561 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 63737015562 heme binding pocket [chemical binding]; other site 63737015563 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 63737015564 substrate binding site [chemical binding]; other site 63737015565 homodimer interface [polypeptide binding]; other site 63737015566 heme binding site [chemical binding]; other site 63737015567 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 63737015568 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 63737015569 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 63737015570 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 63737015571 isocitrate dehydrogenase; Validated; Region: PRK07362 63737015572 GUN4-like; Region: GUN4; pfam05419 63737015573 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 63737015574 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 63737015575 Walker A/P-loop; other site 63737015576 ATP binding site [chemical binding]; other site 63737015577 Q-loop/lid; other site 63737015578 ABC transporter signature motif; other site 63737015579 Walker B; other site 63737015580 D-loop; other site 63737015581 H-loop/switch region; other site 63737015582 TOBE domain; Region: TOBE_2; pfam08402 63737015583 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 63737015584 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 63737015585 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 63737015586 Cache domain; Region: Cache_1; pfam02743 63737015587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737015588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737015589 dimerization interface [polypeptide binding]; other site 63737015590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737015591 dimer interface [polypeptide binding]; other site 63737015592 phosphorylation site [posttranslational modification] 63737015593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015594 ATP binding site [chemical binding]; other site 63737015595 Mg2+ binding site [ion binding]; other site 63737015596 G-X-G motif; other site 63737015597 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737015598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015599 active site 63737015600 phosphorylation site [posttranslational modification] 63737015601 intermolecular recognition site; other site 63737015602 dimerization interface [polypeptide binding]; other site 63737015603 Response regulator receiver domain; Region: Response_reg; pfam00072 63737015604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015605 active site 63737015606 phosphorylation site [posttranslational modification] 63737015607 intermolecular recognition site; other site 63737015608 dimerization interface [polypeptide binding]; other site 63737015609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737015610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737015611 dimer interface [polypeptide binding]; other site 63737015612 phosphorylation site [posttranslational modification] 63737015613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015614 ATP binding site [chemical binding]; other site 63737015615 Mg2+ binding site [ion binding]; other site 63737015616 G-X-G motif; other site 63737015617 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 63737015618 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 63737015619 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 63737015620 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 63737015621 Walker A/P-loop; other site 63737015622 ATP binding site [chemical binding]; other site 63737015623 Q-loop/lid; other site 63737015624 ABC transporter signature motif; other site 63737015625 Walker B; other site 63737015626 D-loop; other site 63737015627 H-loop/switch region; other site 63737015628 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 63737015629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015630 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737015631 TPR motif; other site 63737015632 binding surface 63737015633 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 63737015634 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 63737015635 nudix motif; other site 63737015636 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 63737015637 HicB family; Region: HicB; pfam05534 63737015638 YcfA-like protein; Region: YcfA; cl00752 63737015639 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 63737015640 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 63737015641 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 63737015642 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 63737015643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737015644 ATP binding site [chemical binding]; other site 63737015645 putative Mg++ binding site [ion binding]; other site 63737015646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737015647 nucleotide binding region [chemical binding]; other site 63737015648 ATP-binding site [chemical binding]; other site 63737015649 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 63737015650 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 63737015651 Domain of unknown function DUF21; Region: DUF21; pfam01595 63737015652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 63737015653 Transporter associated domain; Region: CorC_HlyC; smart01091 63737015654 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 63737015655 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737015656 active site 63737015657 catalytic tetrad [active] 63737015658 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737015659 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737015660 acyl-activating enzyme (AAE) consensus motif; other site 63737015661 AMP binding site [chemical binding]; other site 63737015662 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737015663 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737015664 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 63737015665 Bacterial sugar transferase; Region: Bac_transf; pfam02397 63737015666 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 63737015667 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 63737015668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737015669 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737015670 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 63737015671 O-Antigen ligase; Region: Wzy_C; pfam04932 63737015672 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737015673 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737015674 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 63737015675 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 63737015676 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 63737015677 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 63737015678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737015679 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 63737015680 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 63737015681 Chain length determinant protein; Region: Wzz; pfam02706 63737015682 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 63737015683 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 63737015684 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 63737015685 Nucleotide binding site [chemical binding]; other site 63737015686 DTAP/Switch II; other site 63737015687 Switch I; other site 63737015688 Right handed beta helix region; Region: Beta_helix; pfam13229 63737015689 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 63737015690 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 63737015691 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 63737015692 SLBB domain; Region: SLBB; pfam10531 63737015693 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 63737015694 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 63737015695 Walker A/P-loop; other site 63737015696 ATP binding site [chemical binding]; other site 63737015697 Q-loop/lid; other site 63737015698 ABC transporter signature motif; other site 63737015699 Walker B; other site 63737015700 D-loop; other site 63737015701 H-loop/switch region; other site 63737015702 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 63737015703 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 63737015704 putative active site pocket [active] 63737015705 4-fold oligomerization interface [polypeptide binding]; other site 63737015706 metal binding residues [ion binding]; metal-binding site 63737015707 3-fold/trimer interface [polypeptide binding]; other site 63737015708 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 63737015709 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 63737015710 NAD binding site [chemical binding]; other site 63737015711 homotetramer interface [polypeptide binding]; other site 63737015712 homodimer interface [polypeptide binding]; other site 63737015713 substrate binding site [chemical binding]; other site 63737015714 active site 63737015715 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737015716 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 63737015717 ligand binding site [chemical binding]; other site 63737015718 flexible hinge region; other site 63737015719 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 63737015720 putative switch regulator; other site 63737015721 non-specific DNA interactions [nucleotide binding]; other site 63737015722 DNA binding site [nucleotide binding] 63737015723 sequence specific DNA binding site [nucleotide binding]; other site 63737015724 putative cAMP binding site [chemical binding]; other site 63737015725 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 63737015726 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 63737015727 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 63737015728 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 63737015729 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 63737015730 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737015731 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737015732 active site 63737015733 catalytic tetrad [active] 63737015734 PsbP; Region: PsbP; pfam01789 63737015735 Maf-like protein; Region: Maf; pfam02545 63737015736 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 63737015737 active site 63737015738 dimer interface [polypeptide binding]; other site 63737015739 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 63737015740 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 63737015741 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 63737015742 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 63737015743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737015744 CHAT domain; Region: CHAT; cl17868 63737015745 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 63737015746 MoxR-like ATPases [General function prediction only]; Region: COG0714 63737015747 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737015748 Walker A motif; other site 63737015749 ATP binding site [chemical binding]; other site 63737015750 Walker B motif; other site 63737015751 MoxR-like ATPases [General function prediction only]; Region: COG0714 63737015752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 63737015753 Response regulator receiver domain; Region: Response_reg; pfam00072 63737015754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015755 active site 63737015756 phosphorylation site [posttranslational modification] 63737015757 intermolecular recognition site; other site 63737015758 dimerization interface [polypeptide binding]; other site 63737015759 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 63737015760 GUN4-like; Region: GUN4; pfam05419 63737015761 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 63737015762 UbiA prenyltransferase family; Region: UbiA; pfam01040 63737015763 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 63737015764 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 63737015765 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 63737015766 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 63737015767 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 63737015768 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 63737015769 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 63737015770 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 63737015771 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 63737015772 Subunit I/III interface [polypeptide binding]; other site 63737015773 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737015774 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737015775 active site 63737015776 ATP binding site [chemical binding]; other site 63737015777 substrate binding site [chemical binding]; other site 63737015778 activation loop (A-loop); other site 63737015779 PBP superfamily domain; Region: PBP_like_2; pfam12849 63737015780 XisI protein; Region: XisI; pfam08869 63737015781 XisH protein; Region: XisH; pfam08814 63737015782 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737015783 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737015784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015785 binding surface 63737015786 TPR motif; other site 63737015787 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737015788 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737015789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737015790 binding surface 63737015791 TPR motif; other site 63737015792 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737015793 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 63737015794 AAA ATPase domain; Region: AAA_16; pfam13191 63737015795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 63737015796 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 63737015797 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737015798 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737015799 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737015800 Magnesium ion binding site [ion binding]; other site 63737015801 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 63737015802 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 63737015803 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 63737015804 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 63737015805 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 63737015806 Rubredoxin [Energy production and conversion]; Region: COG1773 63737015807 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 63737015808 iron binding site [ion binding]; other site 63737015809 Ycf48-like protein; Provisional; Region: PRK13684 63737015810 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 63737015811 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 63737015812 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 63737015813 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 63737015814 photosystem II reaction center L; Provisional; Region: psbL; PRK00753 63737015815 photosystem II reaction center protein J; Provisional; Region: PRK02565 63737015816 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 63737015817 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 63737015818 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 63737015819 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 63737015820 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 63737015821 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 63737015822 anti sigma factor interaction site; other site 63737015823 regulatory phosphorylation site [posttranslational modification]; other site 63737015824 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 63737015825 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 63737015826 argininosuccinate synthase; Provisional; Region: PRK13820 63737015827 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 63737015828 ANP binding site [chemical binding]; other site 63737015829 Substrate Binding Site II [chemical binding]; other site 63737015830 Substrate Binding Site I [chemical binding]; other site 63737015831 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 63737015832 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 63737015833 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 63737015834 Probable Catalytic site; other site 63737015835 metal-binding site 63737015836 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 63737015837 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 63737015838 generic binding surface II; other site 63737015839 ssDNA binding site; other site 63737015840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737015841 ATP binding site [chemical binding]; other site 63737015842 putative Mg++ binding site [ion binding]; other site 63737015843 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737015844 nucleotide binding region [chemical binding]; other site 63737015845 ATP-binding site [chemical binding]; other site 63737015846 elongation factor Ts; Provisional; Region: tsf; PRK09377 63737015847 UBA/TS-N domain; Region: UBA; pfam00627 63737015848 Elongation factor TS; Region: EF_TS; pfam00889 63737015849 Elongation factor TS; Region: EF_TS; pfam00889 63737015850 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 63737015851 rRNA interaction site [nucleotide binding]; other site 63737015852 S8 interaction site; other site 63737015853 putative laminin-1 binding site; other site 63737015854 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737015855 putative active site [active] 63737015856 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 63737015857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737015858 active site 63737015859 motif I; other site 63737015860 motif II; other site 63737015861 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 63737015862 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 63737015863 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737015864 Walker A/P-loop; other site 63737015865 ATP binding site [chemical binding]; other site 63737015866 Q-loop/lid; other site 63737015867 ABC transporter signature motif; other site 63737015868 Walker B; other site 63737015869 D-loop; other site 63737015870 H-loop/switch region; other site 63737015871 DevC protein; Region: devC; TIGR01185 63737015872 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737015873 FtsX-like permease family; Region: FtsX; pfam02687 63737015874 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 63737015875 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737015876 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737015877 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 63737015878 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737015879 HSP70 interaction site [polypeptide binding]; other site 63737015880 AF-4 proto-oncoprotein; Region: AF-4; pfam05110 63737015881 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 63737015882 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 63737015883 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 63737015884 tetramer interface [polypeptide binding]; other site 63737015885 TPP-binding site [chemical binding]; other site 63737015886 heterodimer interface [polypeptide binding]; other site 63737015887 phosphorylation loop region [posttranslational modification] 63737015888 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 63737015889 active site 63737015890 catalytic residues [active] 63737015891 short chain dehydrogenase; Provisional; Region: PRK06197 63737015892 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 63737015893 putative NAD(P) binding site [chemical binding]; other site 63737015894 active site 63737015895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737015896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737015897 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 63737015898 intersubunit interface [polypeptide binding]; other site 63737015899 active site 63737015900 zinc binding site [ion binding]; other site 63737015901 Na+ binding site [ion binding]; other site 63737015902 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 63737015903 nitrilase; Region: PLN02798 63737015904 putative active site [active] 63737015905 catalytic triad [active] 63737015906 dimer interface [polypeptide binding]; other site 63737015907 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 63737015908 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 63737015909 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737015910 catalytic residues [active] 63737015911 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 63737015912 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 63737015913 active site 63737015914 Uncharacterized conserved protein [Function unknown]; Region: COG1434 63737015915 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 63737015916 putative active site [active] 63737015917 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 63737015918 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 63737015919 active site 63737015920 metal binding site [ion binding]; metal-binding site 63737015921 DNA binding site [nucleotide binding] 63737015922 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 63737015923 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 63737015924 Active Sites [active] 63737015925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737015926 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737015927 putative substrate translocation pore; other site 63737015928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737015929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737015930 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 63737015931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 63737015932 Zn2+ binding site [ion binding]; other site 63737015933 Mg2+ binding site [ion binding]; other site 63737015934 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 63737015935 synthetase active site [active] 63737015936 NTP binding site [chemical binding]; other site 63737015937 metal binding site [ion binding]; metal-binding site 63737015938 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 63737015939 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 63737015940 Domain of unknown function DUF21; Region: DUF21; pfam01595 63737015941 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 63737015942 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 63737015943 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 63737015944 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737015945 hypothetical protein; Provisional; Region: PRK06849 63737015946 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 63737015947 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 63737015948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737015949 S-adenosylmethionine binding site [chemical binding]; other site 63737015950 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 63737015951 active site 63737015952 NAD binding site [chemical binding]; other site 63737015953 metal binding site [ion binding]; metal-binding site 63737015954 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 63737015955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737015956 S-adenosylmethionine binding site [chemical binding]; other site 63737015957 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 63737015958 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 63737015959 active site 63737015960 Zn binding site [ion binding]; other site 63737015961 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737015962 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 63737015963 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737015964 Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the...; Region: Cyclic_amidohydrolases; cd01302 63737015965 active site 63737015966 tetramer interface [polypeptide binding]; other site 63737015967 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 63737015968 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 63737015969 Mgc45594 gene product and other MDR family members; Region: Mgc45594_like; cd08250 63737015970 NADP binding site [chemical binding]; other site 63737015971 dimer interface [polypeptide binding]; other site 63737015972 SnoaL-like domain; Region: SnoaL_2; pfam12680 63737015973 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 63737015974 Response regulator receiver domain; Region: Response_reg; pfam00072 63737015975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015976 active site 63737015977 phosphorylation site [posttranslational modification] 63737015978 intermolecular recognition site; other site 63737015979 dimerization interface [polypeptide binding]; other site 63737015980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737015981 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737015982 putative active site [active] 63737015983 heme pocket [chemical binding]; other site 63737015984 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737015985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737015986 putative active site [active] 63737015987 heme pocket [chemical binding]; other site 63737015988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737015989 dimer interface [polypeptide binding]; other site 63737015990 phosphorylation site [posttranslational modification] 63737015991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737015992 ATP binding site [chemical binding]; other site 63737015993 Mg2+ binding site [ion binding]; other site 63737015994 G-X-G motif; other site 63737015995 Response regulator receiver domain; Region: Response_reg; pfam00072 63737015996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737015997 active site 63737015998 phosphorylation site [posttranslational modification] 63737015999 intermolecular recognition site; other site 63737016000 dimerization interface [polypeptide binding]; other site 63737016001 putative acyl transferase; Provisional; Region: PRK10502 63737016002 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 63737016003 putative trimer interface [polypeptide binding]; other site 63737016004 putative active site [active] 63737016005 putative substrate binding site [chemical binding]; other site 63737016006 putative CoA binding site [chemical binding]; other site 63737016007 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737016008 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 63737016009 putative metal binding site; other site 63737016010 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 63737016011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737016012 active site 63737016013 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 63737016014 homotrimer interface [polypeptide binding]; other site 63737016015 Walker A motif; other site 63737016016 GTP binding site [chemical binding]; other site 63737016017 Walker B motif; other site 63737016018 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 63737016019 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 63737016020 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 63737016021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 63737016022 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 63737016023 ATP-NAD kinase; Region: NAD_kinase; pfam01513 63737016024 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 63737016025 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 63737016026 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 63737016027 NADH dehydrogenase subunit 1; Region: ndhA; CHL00032 63737016028 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 63737016029 citrate synthase; Provisional; Region: PRK14036 63737016030 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 63737016031 dimer interface [polypeptide binding]; other site 63737016032 active site 63737016033 citrylCoA binding site [chemical binding]; other site 63737016034 oxalacetate/citrate binding site [chemical binding]; other site 63737016035 coenzyme A binding site [chemical binding]; other site 63737016036 catalytic triad [active] 63737016037 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 63737016038 catalytic core [active] 63737016039 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737016040 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 63737016041 DHH family; Region: DHH; pfam01368 63737016042 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 63737016043 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 63737016044 active site 63737016045 alanine racemase; Reviewed; Region: alr; PRK00053 63737016046 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 63737016047 active site 63737016048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 63737016049 dimer interface [polypeptide binding]; other site 63737016050 substrate binding site [chemical binding]; other site 63737016051 catalytic residues [active] 63737016052 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 63737016053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737016054 active site 63737016055 motif I; other site 63737016056 motif II; other site 63737016057 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 63737016058 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016060 active site 63737016061 phosphorylation site [posttranslational modification] 63737016062 intermolecular recognition site; other site 63737016063 dimerization interface [polypeptide binding]; other site 63737016064 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016066 active site 63737016067 phosphorylation site [posttranslational modification] 63737016068 intermolecular recognition site; other site 63737016069 dimerization interface [polypeptide binding]; other site 63737016070 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 63737016071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737016072 dimerization interface [polypeptide binding]; other site 63737016073 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737016074 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737016075 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 63737016076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737016077 dimer interface [polypeptide binding]; other site 63737016078 putative CheW interface [polypeptide binding]; other site 63737016079 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737016080 putative binding surface; other site 63737016081 active site 63737016082 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 63737016083 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 63737016084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737016085 ATP binding site [chemical binding]; other site 63737016086 Mg2+ binding site [ion binding]; other site 63737016087 G-X-G motif; other site 63737016088 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 63737016089 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016091 active site 63737016092 phosphorylation site [posttranslational modification] 63737016093 intermolecular recognition site; other site 63737016094 dimerization interface [polypeptide binding]; other site 63737016095 Caspase domain; Region: Peptidase_C14; pfam00656 63737016096 GUN4-like; Region: GUN4; pfam05419 63737016097 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 63737016098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 63737016099 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 63737016100 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 63737016101 N-acetyl-D-glucosamine binding site [chemical binding]; other site 63737016102 catalytic residue [active] 63737016103 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 63737016104 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 63737016105 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737016106 putative active site [active] 63737016107 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 63737016108 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 63737016109 hypothetical protein; Validated; Region: PRK00110 63737016110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 63737016111 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 63737016112 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 63737016113 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737016114 active site 63737016115 metal binding site [ion binding]; metal-binding site 63737016116 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 63737016117 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 63737016118 DNA binding residues [nucleotide binding] 63737016119 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 63737016120 Methyltransferase domain; Region: Methyltransf_26; pfam13659 63737016121 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 63737016122 XisI protein; Region: XisI; pfam08869 63737016123 XisH protein; Region: XisH; pfam08814 63737016124 TIGR02687 family protein; Region: TIGR02687 63737016125 PglZ domain; Region: PglZ; pfam08665 63737016126 conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653 63737016127 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 63737016128 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 63737016129 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 63737016130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 63737016131 CHAT domain; Region: CHAT; pfam12770 63737016132 TniQ; Region: TniQ; pfam06527 63737016133 AAA domain; Region: AAA_22; pfam13401 63737016134 Bacterial TniB protein; Region: TniB; pfam05621 63737016135 Homeodomain-like domain; Region: HTH_23; pfam13384 63737016136 Winged helix-turn helix; Region: HTH_29; pfam13551 63737016137 Integrase core domain; Region: rve; pfam00665 63737016138 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 63737016139 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 63737016140 Transposase; Region: DEDD_Tnp_IS110; pfam01548 63737016141 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 63737016142 PBP superfamily domain; Region: PBP_like_2; cl17296 63737016143 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 63737016144 ResB-like family; Region: ResB; pfam05140 63737016145 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 63737016146 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 63737016147 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737016148 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737016149 active site 63737016150 ATP binding site [chemical binding]; other site 63737016151 substrate binding site [chemical binding]; other site 63737016152 activation loop (A-loop); other site 63737016153 AAA ATPase domain; Region: AAA_16; pfam13191 63737016154 Predicted ATPase [General function prediction only]; Region: COG3899 63737016155 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737016156 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737016157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016158 PAS fold; Region: PAS_3; pfam08447 63737016159 putative active site [active] 63737016160 heme pocket [chemical binding]; other site 63737016161 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737016162 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737016163 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737016164 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737016165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737016166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737016167 dimer interface [polypeptide binding]; other site 63737016168 phosphorylation site [posttranslational modification] 63737016169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737016170 ATP binding site [chemical binding]; other site 63737016171 Mg2+ binding site [ion binding]; other site 63737016172 G-X-G motif; other site 63737016173 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016175 active site 63737016176 phosphorylation site [posttranslational modification] 63737016177 intermolecular recognition site; other site 63737016178 dimerization interface [polypeptide binding]; other site 63737016179 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737016180 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737016181 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737016182 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737016183 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016184 PAS domain; Region: PAS_9; pfam13426 63737016185 putative active site [active] 63737016186 heme pocket [chemical binding]; other site 63737016187 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 63737016188 cyclase homology domain; Region: CHD; cd07302 63737016189 nucleotidyl binding site; other site 63737016190 metal binding site [ion binding]; metal-binding site 63737016191 dimer interface [polypeptide binding]; other site 63737016192 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 63737016193 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016195 active site 63737016196 phosphorylation site [posttranslational modification] 63737016197 intermolecular recognition site; other site 63737016198 dimerization interface [polypeptide binding]; other site 63737016199 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 63737016200 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 63737016201 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 63737016202 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 63737016203 generic binding surface I; other site 63737016204 generic binding surface II; other site 63737016205 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 63737016206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737016207 dimer interface [polypeptide binding]; other site 63737016208 conserved gate region; other site 63737016209 putative PBP binding loops; other site 63737016210 ABC-ATPase subunit interface; other site 63737016211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737016212 dimer interface [polypeptide binding]; other site 63737016213 conserved gate region; other site 63737016214 putative PBP binding loops; other site 63737016215 ABC-ATPase subunit interface; other site 63737016216 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 63737016217 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 63737016218 Walker A/P-loop; other site 63737016219 ATP binding site [chemical binding]; other site 63737016220 Q-loop/lid; other site 63737016221 ABC transporter signature motif; other site 63737016222 Walker B; other site 63737016223 D-loop; other site 63737016224 H-loop/switch region; other site 63737016225 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 63737016226 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737016227 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016228 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737016230 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 63737016231 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 63737016232 putative dimerization interface [polypeptide binding]; other site 63737016233 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 63737016234 Cadmium resistance transporter; Region: Cad; pfam03596 63737016235 Domain of unknown function (DUF202); Region: DUF202; pfam02656 63737016236 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737016237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737016238 S-adenosylmethionine binding site [chemical binding]; other site 63737016239 conjugal transfer protein TraL; Provisional; Region: PRK13886 63737016240 CHAT domain; Region: CHAT; pfam12770 63737016241 AAA ATPase domain; Region: AAA_16; pfam13191 63737016242 TPR repeat; Region: TPR_11; pfam13414 63737016243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016244 binding surface 63737016245 TPR motif; other site 63737016246 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016248 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016249 TPR motif; other site 63737016250 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016251 binding surface 63737016252 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016253 binding surface 63737016254 TPR motif; other site 63737016255 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016256 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016258 binding surface 63737016259 TPR motif; other site 63737016260 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016262 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016263 binding surface 63737016264 TPR motif; other site 63737016265 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016266 Pirin-related protein [General function prediction only]; Region: COG1741 63737016267 Pirin; Region: Pirin; pfam02678 63737016268 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 63737016269 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 63737016270 dimerization interface [polypeptide binding]; other site 63737016271 DPS ferroxidase diiron center [ion binding]; other site 63737016272 ion pore; other site 63737016273 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737016274 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737016275 active site 63737016276 catalytic tetrad [active] 63737016277 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737016278 putative active site [active] 63737016279 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 63737016280 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 63737016281 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 63737016282 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 63737016283 catalytic site [active] 63737016284 active site 63737016285 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 63737016286 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 63737016287 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 63737016288 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 63737016289 active site 63737016290 catalytic site [active] 63737016291 Trehalase; Region: Trehalase; cl17346 63737016292 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 63737016293 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 63737016294 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 63737016295 active site 63737016296 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 63737016297 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 63737016298 active site 63737016299 (T/H)XGH motif; other site 63737016300 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 63737016301 nudix motif; other site 63737016302 NAD synthetase; Provisional; Region: PRK13981 63737016303 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 63737016304 multimer interface [polypeptide binding]; other site 63737016305 active site 63737016306 catalytic triad [active] 63737016307 protein interface 1 [polypeptide binding]; other site 63737016308 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 63737016309 homodimer interface [polypeptide binding]; other site 63737016310 NAD binding pocket [chemical binding]; other site 63737016311 ATP binding pocket [chemical binding]; other site 63737016312 Mg binding site [ion binding]; other site 63737016313 active-site loop [active] 63737016314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737016315 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737016316 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 63737016317 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 63737016318 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 63737016319 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 63737016320 active site 63737016321 substrate binding site [chemical binding]; other site 63737016322 FMN binding site [chemical binding]; other site 63737016323 putative catalytic residues [active] 63737016324 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 63737016325 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 63737016326 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 63737016327 hinge; other site 63737016328 active site 63737016329 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 63737016330 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 63737016331 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 63737016332 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737016333 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 63737016334 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737016335 N-terminal domain interface [polypeptide binding]; other site 63737016336 dimer interface [polypeptide binding]; other site 63737016337 substrate binding pocket (H-site) [chemical binding]; other site 63737016338 tyrosine phenol-lyase; Provisional; Region: PRK13237 63737016339 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 63737016340 substrate binding site [chemical binding]; other site 63737016341 tetramer interface [polypeptide binding]; other site 63737016342 catalytic residue [active] 63737016343 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 63737016344 nudix motif; other site 63737016345 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737016346 putative active site [active] 63737016347 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 63737016348 active site 63737016349 dimer interface [polypeptide binding]; other site 63737016350 metal binding site [ion binding]; metal-binding site 63737016351 biotin synthase; Region: bioB; TIGR00433 63737016352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737016353 FeS/SAM binding site; other site 63737016354 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 63737016355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 63737016356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 63737016357 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 63737016358 hypothetical protein; Validated; Region: PRK00029 63737016359 Uncharacterized conserved protein [Function unknown]; Region: COG0397 63737016360 TIR domain; Region: TIR_2; pfam13676 63737016361 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 63737016362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 63737016363 catalytic core [active] 63737016364 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 63737016365 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737016366 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 63737016367 Walker A/P-loop; other site 63737016368 ATP binding site [chemical binding]; other site 63737016369 Q-loop/lid; other site 63737016370 ABC transporter signature motif; other site 63737016371 Walker B; other site 63737016372 D-loop; other site 63737016373 H-loop/switch region; other site 63737016374 Protein of unknown function (DUF433); Region: DUF433; pfam04255 63737016375 PRC-barrel domain; Region: PRC; pfam05239 63737016376 PRC-barrel domain; Region: PRC; pfam05239 63737016377 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 63737016378 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 63737016379 Walker A/P-loop; other site 63737016380 ATP binding site [chemical binding]; other site 63737016381 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 63737016382 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 63737016383 ABC transporter signature motif; other site 63737016384 Walker B; other site 63737016385 D-loop; other site 63737016386 H-loop/switch region; other site 63737016387 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 63737016388 catalytic site [active] 63737016389 putative active site [active] 63737016390 putative substrate binding site [chemical binding]; other site 63737016391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016392 binding surface 63737016393 TPR repeat; Region: TPR_11; pfam13414 63737016394 TPR motif; other site 63737016395 TPR repeat; Region: TPR_11; pfam13414 63737016396 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016397 TPR motif; other site 63737016398 binding surface 63737016399 TPR repeat; Region: TPR_11; pfam13414 63737016400 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 63737016401 putative active site [active] 63737016402 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016404 binding surface 63737016405 TPR motif; other site 63737016406 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016407 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016408 CHAT domain; Region: CHAT; pfam12770 63737016409 AAA ATPase domain; Region: AAA_16; pfam13191 63737016410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016412 binding surface 63737016413 TPR motif; other site 63737016414 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016415 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737016417 binding surface 63737016418 TPR motif; other site 63737016419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737016420 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 63737016421 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 63737016422 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 63737016423 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 63737016424 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 63737016425 trimer interface [polypeptide binding]; other site 63737016426 active site 63737016427 substrate binding site [chemical binding]; other site 63737016428 CoA binding site [chemical binding]; other site 63737016429 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 63737016430 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 63737016431 active site residue [active] 63737016432 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 63737016433 polyphosphate kinase; Provisional; Region: PRK05443 63737016434 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 63737016435 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 63737016436 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 63737016437 putative domain interface [polypeptide binding]; other site 63737016438 putative active site [active] 63737016439 catalytic site [active] 63737016440 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 63737016441 putative domain interface [polypeptide binding]; other site 63737016442 putative active site [active] 63737016443 catalytic site [active] 63737016444 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016446 active site 63737016447 phosphorylation site [posttranslational modification] 63737016448 intermolecular recognition site; other site 63737016449 dimerization interface [polypeptide binding]; other site 63737016450 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 63737016451 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 63737016452 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016454 active site 63737016455 phosphorylation site [posttranslational modification] 63737016456 intermolecular recognition site; other site 63737016457 dimerization interface [polypeptide binding]; other site 63737016458 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737016459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737016460 metal binding site [ion binding]; metal-binding site 63737016461 active site 63737016462 I-site; other site 63737016463 adaptive-response sensory kinase; Validated; Region: PRK09303 63737016464 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 63737016465 tetramer interface [polypeptide binding]; other site 63737016466 dimer interface [polypeptide binding]; other site 63737016467 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737016468 dimer interface [polypeptide binding]; other site 63737016469 phosphorylation site [posttranslational modification] 63737016470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737016471 ATP binding site [chemical binding]; other site 63737016472 Mg2+ binding site [ion binding]; other site 63737016473 G-X-G motif; other site 63737016474 S-layer homology domain; Region: SLH; pfam00395 63737016475 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 63737016476 active site 63737016477 catalytic triad [active] 63737016478 oxyanion hole [active] 63737016479 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 63737016480 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 63737016481 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 63737016482 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 63737016483 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 63737016484 S-layer homology domain; Region: SLH; pfam00395 63737016485 S-layer homology domain; Region: SLH; pfam00395 63737016486 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737016487 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 63737016488 translation initiation factor IF-2; Region: IF-2; TIGR00487 63737016489 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 63737016490 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 63737016491 G1 box; other site 63737016492 putative GEF interaction site [polypeptide binding]; other site 63737016493 GTP/Mg2+ binding site [chemical binding]; other site 63737016494 Switch I region; other site 63737016495 G2 box; other site 63737016496 G3 box; other site 63737016497 Switch II region; other site 63737016498 G4 box; other site 63737016499 G5 box; other site 63737016500 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 63737016501 Translation-initiation factor 2; Region: IF-2; pfam11987 63737016502 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 63737016503 Protein of unknown function (DUF448); Region: DUF448; pfam04296 63737016504 putative RNA binding cleft [nucleotide binding]; other site 63737016505 NusA N-terminal domain; Region: NusA_N; pfam08529 63737016506 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 63737016507 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 63737016508 RNA binding site [nucleotide binding]; other site 63737016509 homodimer interface [polypeptide binding]; other site 63737016510 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 63737016511 G-X-X-G motif; other site 63737016512 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 63737016513 G-X-X-G motif; other site 63737016514 ribosome maturation protein RimP; Reviewed; Region: PRK00092 63737016515 Sm and related proteins; Region: Sm_like; cl00259 63737016516 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 63737016517 putative oligomer interface [polypeptide binding]; other site 63737016518 putative RNA binding site [nucleotide binding]; other site 63737016519 pathogenicity island 2 effector protein SseC; Provisional; Region: PRK15362 63737016520 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 63737016521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737016522 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737016523 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 63737016524 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 63737016525 active site 63737016526 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737016527 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737016528 active site 63737016529 ATP binding site [chemical binding]; other site 63737016530 substrate binding site [chemical binding]; other site 63737016531 activation loop (A-loop); other site 63737016532 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737016533 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737016534 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737016535 structural tetrad; other site 63737016536 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 63737016537 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737016538 dimerization interface [polypeptide binding]; other site 63737016539 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 63737016540 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737016541 active site 63737016542 ATP binding site [chemical binding]; other site 63737016543 substrate binding site [chemical binding]; other site 63737016544 activation loop (A-loop); other site 63737016545 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737016546 putative active site [active] 63737016547 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 63737016548 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737016549 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 63737016550 putative active site [active] 63737016551 DNA repair protein RadA; Provisional; Region: PRK11823 63737016552 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 63737016553 Walker A motif/ATP binding site; other site 63737016554 ATP binding site [chemical binding]; other site 63737016555 Walker B motif; other site 63737016556 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 63737016557 Ycf27; Reviewed; Region: orf27; CHL00148 63737016558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016559 active site 63737016560 phosphorylation site [posttranslational modification] 63737016561 intermolecular recognition site; other site 63737016562 dimerization interface [polypeptide binding]; other site 63737016563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737016564 DNA binding site [nucleotide binding] 63737016565 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 63737016566 Peptidase family M48; Region: Peptidase_M48; cl12018 63737016567 Protein of unknown function (DUF456); Region: DUF456; cl01069 63737016568 HEAT repeats; Region: HEAT_2; pfam13646 63737016569 HEAT repeats; Region: HEAT_2; pfam13646 63737016570 FOG: CBS domain [General function prediction only]; Region: COG0517 63737016571 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 63737016572 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 63737016573 active site 63737016574 8-oxo-dGMP binding site [chemical binding]; other site 63737016575 nudix motif; other site 63737016576 metal binding site [ion binding]; metal-binding site 63737016577 Protein of unknown function (DUF760); Region: DUF760; pfam05542 63737016578 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 63737016579 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737016580 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737016581 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737016582 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737016583 DNA binding residues [nucleotide binding] 63737016584 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 63737016585 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 63737016586 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 63737016587 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 63737016588 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 63737016589 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737016590 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 63737016591 IMP binding site; other site 63737016592 dimer interface [polypeptide binding]; other site 63737016593 interdomain contacts; other site 63737016594 partial ornithine binding site; other site 63737016595 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 63737016596 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 63737016597 dimerization interface [polypeptide binding]; other site 63737016598 DPS ferroxidase diiron center [ion binding]; other site 63737016599 ion pore; other site 63737016600 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 63737016601 dimer interface [polypeptide binding]; other site 63737016602 [2Fe-2S] cluster binding site [ion binding]; other site 63737016603 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 63737016604 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737016605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016606 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016607 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737016608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016609 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 63737016610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737016611 dimer interface [polypeptide binding]; other site 63737016612 conserved gate region; other site 63737016613 ABC-ATPase subunit interface; other site 63737016614 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 63737016615 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737016616 Walker A/P-loop; other site 63737016617 ATP binding site [chemical binding]; other site 63737016618 Q-loop/lid; other site 63737016619 ABC transporter signature motif; other site 63737016620 Walker B; other site 63737016621 D-loop; other site 63737016622 H-loop/switch region; other site 63737016623 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 63737016624 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737016625 substrate binding pocket [chemical binding]; other site 63737016626 membrane-bound complex binding site; other site 63737016627 hinge residues; other site 63737016628 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737016629 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016630 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016631 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016633 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016634 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737016635 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 63737016636 homotrimer interaction site [polypeptide binding]; other site 63737016637 putative active site [active] 63737016638 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 63737016639 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737016640 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 63737016641 nudix motif; other site 63737016642 4-alpha-glucanotransferase; Provisional; Region: PRK14508 63737016643 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 63737016644 Helix-turn-helix domain; Region: HTH_25; pfam13413 63737016645 non-specific DNA binding site [nucleotide binding]; other site 63737016646 salt bridge; other site 63737016647 sequence-specific DNA binding site [nucleotide binding]; other site 63737016648 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 63737016649 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 63737016650 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 63737016651 RNA binding surface [nucleotide binding]; other site 63737016652 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 63737016653 active site 63737016654 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 63737016655 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 63737016656 phosphatidate cytidylyltransferase; Region: PLN02953 63737016657 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 63737016658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737016659 S-adenosylmethionine binding site [chemical binding]; other site 63737016660 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737016661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737016662 active site 63737016663 ATP binding site [chemical binding]; other site 63737016664 substrate binding site [chemical binding]; other site 63737016665 activation loop (A-loop); other site 63737016666 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 63737016667 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 63737016668 ATP-grasp domain; Region: ATP-grasp_4; cl17255 63737016669 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 63737016670 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 63737016671 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 63737016672 proposed catalytic triad [active] 63737016673 active site nucleophile [active] 63737016674 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 63737016675 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 63737016676 homotrimer interaction site [polypeptide binding]; other site 63737016677 zinc binding site [ion binding]; other site 63737016678 CDP-binding sites; other site 63737016679 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 63737016680 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 63737016681 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 63737016682 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 63737016683 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 63737016684 AIR carboxylase; Region: AIRC; smart01001 63737016685 argininosuccinate lyase; Provisional; Region: PRK00855 63737016686 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 63737016687 active sites [active] 63737016688 tetramer interface [polypeptide binding]; other site 63737016689 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 63737016690 nudix motif; other site 63737016691 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737016692 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 63737016693 pantothenate kinase; Reviewed; Region: PRK13331 63737016694 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 63737016695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 63737016696 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 63737016697 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 63737016698 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 63737016699 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 63737016700 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 63737016701 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 63737016702 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 63737016703 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 63737016704 CpeS-like protein; Region: CpeS; pfam09367 63737016705 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737016706 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737016707 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 63737016708 Protein export membrane protein; Region: SecD_SecF; cl14618 63737016709 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737016710 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737016711 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 63737016712 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 63737016713 active site 63737016714 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 63737016715 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 63737016716 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 63737016717 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 63737016718 putative homodimer interface [polypeptide binding]; other site 63737016719 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 63737016720 heterodimer interface [polypeptide binding]; other site 63737016721 homodimer interface [polypeptide binding]; other site 63737016722 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 63737016723 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 63737016724 23S rRNA interface [nucleotide binding]; other site 63737016725 L7/L12 interface [polypeptide binding]; other site 63737016726 putative thiostrepton binding site; other site 63737016727 L25 interface [polypeptide binding]; other site 63737016728 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 63737016729 mRNA/rRNA interface [nucleotide binding]; other site 63737016730 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 63737016731 23S rRNA interface [nucleotide binding]; other site 63737016732 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 63737016733 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 63737016734 peripheral dimer interface [polypeptide binding]; other site 63737016735 core dimer interface [polypeptide binding]; other site 63737016736 L10 interface [polypeptide binding]; other site 63737016737 L11 interface [polypeptide binding]; other site 63737016738 putative EF-Tu interaction site [polypeptide binding]; other site 63737016739 putative EF-G interaction site [polypeptide binding]; other site 63737016740 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 63737016741 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 63737016742 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 63737016743 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 63737016744 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 63737016745 active site 63737016746 dimer interface [polypeptide binding]; other site 63737016747 motif 1; other site 63737016748 motif 2; other site 63737016749 motif 3; other site 63737016750 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 63737016751 anticodon binding site; other site 63737016752 Cupin domain; Region: Cupin_2; pfam07883 63737016753 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 63737016754 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737016755 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737016756 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737016757 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737016758 ligand binding site [chemical binding]; other site 63737016759 flexible hinge region; other site 63737016760 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 63737016761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737016762 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 63737016763 4Fe-4S binding domain; Region: Fer4_5; pfam12801 63737016764 Class I aldolases; Region: Aldolase_Class_I; cl17187 63737016765 catalytic residue [active] 63737016766 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737016767 CHASE2 domain; Region: CHASE2; pfam05226 63737016768 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737016769 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737016770 active site 63737016771 ATP binding site [chemical binding]; other site 63737016772 substrate binding site [chemical binding]; other site 63737016773 activation loop (A-loop); other site 63737016774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737016775 non-specific DNA binding site [nucleotide binding]; other site 63737016776 salt bridge; other site 63737016777 sequence-specific DNA binding site [nucleotide binding]; other site 63737016778 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 63737016779 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737016780 substrate binding pocket [chemical binding]; other site 63737016781 membrane-bound complex binding site; other site 63737016782 hinge residues; other site 63737016783 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 63737016784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737016785 substrate binding pocket [chemical binding]; other site 63737016786 membrane-bound complex binding site; other site 63737016787 hinge residues; other site 63737016788 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 63737016789 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737016790 active site 63737016791 iron coordination sites [ion binding]; other site 63737016792 substrate binding pocket [chemical binding]; other site 63737016793 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 63737016794 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737016795 substrate binding pocket [chemical binding]; other site 63737016796 membrane-bound complex binding site; other site 63737016797 hinge residues; other site 63737016798 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737016799 S-adenosylmethionine binding site [chemical binding]; other site 63737016800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737016801 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737016802 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 63737016803 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 63737016804 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 63737016805 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 63737016806 Ligand binding site; other site 63737016807 Putative Catalytic site; other site 63737016808 DXD motif; other site 63737016809 Uncharacterized conserved protein [Function unknown]; Region: COG0398 63737016810 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 63737016811 S-layer homology domain; Region: SLH; pfam00395 63737016812 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 63737016813 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 63737016814 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 63737016815 active site 63737016816 dimer interface [polypeptide binding]; other site 63737016817 non-prolyl cis peptide bond; other site 63737016818 insertion regions; other site 63737016819 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 63737016820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737016821 dimer interface [polypeptide binding]; other site 63737016822 conserved gate region; other site 63737016823 putative PBP binding loops; other site 63737016824 ABC-ATPase subunit interface; other site 63737016825 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 63737016826 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 63737016827 Walker A/P-loop; other site 63737016828 ATP binding site [chemical binding]; other site 63737016829 Q-loop/lid; other site 63737016830 ABC transporter signature motif; other site 63737016831 Walker B; other site 63737016832 D-loop; other site 63737016833 H-loop/switch region; other site 63737016834 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 63737016835 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 63737016836 NAD binding site [chemical binding]; other site 63737016837 ligand binding site [chemical binding]; other site 63737016838 catalytic site [active] 63737016839 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 63737016840 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 63737016841 NAD binding site [chemical binding]; other site 63737016842 ligand binding site [chemical binding]; other site 63737016843 catalytic site [active] 63737016844 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 63737016845 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737016846 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 63737016847 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 63737016848 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 63737016849 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737016850 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737016851 ligand binding site [chemical binding]; other site 63737016852 flexible hinge region; other site 63737016853 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 63737016854 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 63737016855 putative active site [active] 63737016856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737016857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737016858 Walker A/P-loop; other site 63737016859 ATP binding site [chemical binding]; other site 63737016860 Q-loop/lid; other site 63737016861 ABC transporter signature motif; other site 63737016862 Walker B; other site 63737016863 D-loop; other site 63737016864 H-loop/switch region; other site 63737016865 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 63737016866 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 63737016867 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737016868 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 63737016869 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 63737016870 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016872 active site 63737016873 phosphorylation site [posttranslational modification] 63737016874 intermolecular recognition site; other site 63737016875 dimerization interface [polypeptide binding]; other site 63737016876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016877 putative active site [active] 63737016878 heme pocket [chemical binding]; other site 63737016879 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737016880 PAS domain S-box; Region: sensory_box; TIGR00229 63737016881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016882 putative active site [active] 63737016883 heme pocket [chemical binding]; other site 63737016884 PAS domain S-box; Region: sensory_box; TIGR00229 63737016885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016886 putative active site [active] 63737016887 heme pocket [chemical binding]; other site 63737016888 PAS fold; Region: PAS_7; pfam12860 63737016889 PAS domain S-box; Region: sensory_box; TIGR00229 63737016890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016891 putative active site [active] 63737016892 heme pocket [chemical binding]; other site 63737016893 PAS domain S-box; Region: sensory_box; TIGR00229 63737016894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016895 putative active site [active] 63737016896 heme pocket [chemical binding]; other site 63737016897 GAF domain; Region: GAF; pfam01590 63737016898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737016899 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737016900 dimer interface [polypeptide binding]; other site 63737016901 phosphorylation site [posttranslational modification] 63737016902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737016903 ATP binding site [chemical binding]; other site 63737016904 Mg2+ binding site [ion binding]; other site 63737016905 G-X-G motif; other site 63737016906 Response regulator receiver domain; Region: Response_reg; pfam00072 63737016907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737016908 active site 63737016909 phosphorylation site [posttranslational modification] 63737016910 intermolecular recognition site; other site 63737016911 dimerization interface [polypeptide binding]; other site 63737016912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737016913 putative active site [active] 63737016914 heme pocket [chemical binding]; other site 63737016915 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737016916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737016917 non-specific DNA binding site [nucleotide binding]; other site 63737016918 salt bridge; other site 63737016919 sequence-specific DNA binding site [nucleotide binding]; other site 63737016920 PBP superfamily domain; Region: PBP_like; pfam12727 63737016921 nitrogenase reductase; Reviewed; Region: PRK13236 63737016922 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 63737016923 Nucleotide-binding sites [chemical binding]; other site 63737016924 Walker A motif; other site 63737016925 Switch I region of nucleotide binding site; other site 63737016926 Fe4S4 binding sites [ion binding]; other site 63737016927 Switch II region of nucleotide binding site; other site 63737016928 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 63737016929 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 63737016930 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 63737016931 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 63737016932 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 63737016933 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 63737016934 nucleotide binding site [chemical binding]; other site 63737016935 NEF interaction site [polypeptide binding]; other site 63737016936 SBD interface [polypeptide binding]; other site 63737016937 chaperone protein DnaJ; Provisional; Region: PRK14299 63737016938 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737016939 HSP70 interaction site [polypeptide binding]; other site 63737016940 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 63737016941 substrate binding site [polypeptide binding]; other site 63737016942 dimer interface [polypeptide binding]; other site 63737016943 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 63737016944 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 63737016945 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 63737016946 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737016947 C-terminal domain interface [polypeptide binding]; other site 63737016948 GSH binding site (G-site) [chemical binding]; other site 63737016949 dimer interface [polypeptide binding]; other site 63737016950 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 63737016951 substrate binding pocket (H-site) [chemical binding]; other site 63737016952 N-terminal domain interface [polypeptide binding]; other site 63737016953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737016954 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 63737016955 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 63737016956 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 63737016957 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737016958 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737016959 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737016960 active site 63737016961 catalytic tetrad [active] 63737016962 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 63737016963 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737016964 putative di-iron ligands [ion binding]; other site 63737016965 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 63737016966 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 63737016967 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 63737016968 Protein of unknown function DUF89; Region: DUF89; pfam01937 63737016969 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 63737016970 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 63737016971 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 63737016972 active site 63737016973 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 63737016974 Uncharacterized conserved protein [Function unknown]; Region: COG3937 63737016975 YCII-related domain; Region: YCII; cl00999 63737016976 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 63737016977 TAP-like protein; Region: Abhydrolase_4; pfam08386 63737016978 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 63737016979 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 63737016980 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 63737016981 active site 63737016982 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 63737016983 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 63737016984 nudix motif; other site 63737016985 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 63737016986 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 63737016987 Predicted membrane protein [Function unknown]; Region: COG4872 63737016988 GDYXXLXY protein; Region: GDYXXLXY; cl02066 63737016989 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737016990 Ligand Binding Site [chemical binding]; other site 63737016991 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 63737016992 Phosphoglycerate kinase; Region: PGK; pfam00162 63737016993 substrate binding site [chemical binding]; other site 63737016994 hinge regions; other site 63737016995 ADP binding site [chemical binding]; other site 63737016996 catalytic site [active] 63737016997 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 63737016998 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 63737016999 nudix motif; other site 63737017000 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 63737017001 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 63737017002 Walker A/P-loop; other site 63737017003 ATP binding site [chemical binding]; other site 63737017004 Q-loop/lid; other site 63737017005 ABC transporter signature motif; other site 63737017006 Walker B; other site 63737017007 D-loop; other site 63737017008 H-loop/switch region; other site 63737017009 TOBE domain; Region: TOBE_2; pfam08402 63737017010 hypothetical protein; Provisional; Region: PRK06185 63737017011 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 63737017012 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 63737017013 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 63737017014 dimer interface [polypeptide binding]; other site 63737017015 ssDNA binding site [nucleotide binding]; other site 63737017016 tetramer (dimer of dimers) interface [polypeptide binding]; other site 63737017017 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 63737017018 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 63737017019 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 63737017020 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 63737017021 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 63737017022 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 63737017023 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 63737017024 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 63737017025 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 63737017026 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 63737017027 Predicted integral membrane protein [Function unknown]; Region: COG0762 63737017028 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 63737017029 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 63737017030 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 63737017031 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 63737017032 Protein of unknown function (DUF98); Region: DUF98; pfam01947 63737017033 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737017034 putative active site [active] 63737017035 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 63737017036 cytochrome c biogenesis protein; Region: ccsA; CHL00045 63737017037 KGK domain; Region: KGK; pfam08872 63737017038 KGK domain; Region: KGK; pfam08872 63737017039 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 63737017040 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 63737017041 Ligand Binding Site [chemical binding]; other site 63737017042 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 63737017043 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 63737017044 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 63737017045 Response regulator receiver domain; Region: Response_reg; pfam00072 63737017046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017047 active site 63737017048 phosphorylation site [posttranslational modification] 63737017049 intermolecular recognition site; other site 63737017050 dimerization interface [polypeptide binding]; other site 63737017051 Response regulator receiver domain; Region: Response_reg; pfam00072 63737017052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017053 active site 63737017054 phosphorylation site [posttranslational modification] 63737017055 intermolecular recognition site; other site 63737017056 dimerization interface [polypeptide binding]; other site 63737017057 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 63737017058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737017059 binding surface 63737017060 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737017061 TPR motif; other site 63737017062 HAMP domain; Region: HAMP; pfam00672 63737017063 dimerization interface [polypeptide binding]; other site 63737017064 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 63737017065 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737017066 dimer interface [polypeptide binding]; other site 63737017067 putative CheW interface [polypeptide binding]; other site 63737017068 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737017069 putative binding surface; other site 63737017070 active site 63737017071 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 63737017072 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 63737017073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017074 ATP binding site [chemical binding]; other site 63737017075 Mg2+ binding site [ion binding]; other site 63737017076 G-X-G motif; other site 63737017077 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 63737017078 Response regulator receiver domain; Region: Response_reg; pfam00072 63737017079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017080 active site 63737017081 phosphorylation site [posttranslational modification] 63737017082 intermolecular recognition site; other site 63737017083 dimerization interface [polypeptide binding]; other site 63737017084 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 63737017085 TPR repeat; Region: TPR_11; pfam13414 63737017086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737017087 binding surface 63737017088 TPR motif; other site 63737017089 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737017090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 63737017091 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 63737017092 active site 63737017093 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 63737017094 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 63737017095 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 63737017096 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 63737017097 Predicted integral membrane protein [Function unknown]; Region: COG5542 63737017098 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 63737017099 EamA-like transporter family; Region: EamA; pfam00892 63737017100 EamA-like transporter family; Region: EamA; pfam00892 63737017101 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 63737017102 EamA-like transporter family; Region: EamA; pfam00892 63737017103 Predicted integral membrane protein [Function unknown]; Region: COG5542 63737017104 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 63737017105 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 63737017106 Predicted membrane protein [Function unknown]; Region: COG3463 63737017107 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 63737017108 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 63737017109 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 63737017110 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737017111 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737017112 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 63737017113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737017114 motif II; other site 63737017115 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 63737017116 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 63737017117 Double zinc ribbon; Region: DZR; pfam12773 63737017118 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 63737017119 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 63737017120 active site 63737017121 active site 63737017122 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 63737017123 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 63737017124 putative metal binding site [ion binding]; other site 63737017125 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 63737017126 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 63737017127 putative metal binding site [ion binding]; other site 63737017128 Winged helix-turn helix; Region: HTH_29; pfam13551 63737017129 Homeodomain-like domain; Region: HTH_23; pfam13384 63737017130 Homeodomain-like domain; Region: HTH_32; pfam13565 63737017131 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737017132 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737017133 Clp protease ATP binding subunit; Region: clpC; CHL00095 63737017134 Clp amino terminal domain; Region: Clp_N; pfam02861 63737017135 Clp amino terminal domain; Region: Clp_N; pfam02861 63737017136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737017137 Walker A motif; other site 63737017138 ATP binding site [chemical binding]; other site 63737017139 Walker B motif; other site 63737017140 arginine finger; other site 63737017141 UvrB/uvrC motif; Region: UVR; pfam02151 63737017142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737017143 Walker A motif; other site 63737017144 ATP binding site [chemical binding]; other site 63737017145 Walker B motif; other site 63737017146 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 63737017147 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 63737017148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737017149 Coenzyme A binding pocket [chemical binding]; other site 63737017150 diaminopimelate decarboxylase; Region: lysA; TIGR01048 63737017151 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 63737017152 active site 63737017153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 63737017154 substrate binding site [chemical binding]; other site 63737017155 catalytic residues [active] 63737017156 dimer interface [polypeptide binding]; other site 63737017157 Uncharacterized conserved protein [Function unknown]; Region: COG1624 63737017158 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 63737017159 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 63737017160 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 63737017161 catalytic residue [active] 63737017162 putative FPP diphosphate binding site; other site 63737017163 putative FPP binding hydrophobic cleft; other site 63737017164 dimer interface [polypeptide binding]; other site 63737017165 putative IPP diphosphate binding site; other site 63737017166 PIN domain; Region: PIN_3; cl17397 63737017167 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 63737017168 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737017169 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 63737017170 HSP70 interaction site [polypeptide binding]; other site 63737017171 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 63737017172 chaperone protein DnaJ; Provisional; Region: PRK14299 63737017173 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737017174 HSP70 interaction site [polypeptide binding]; other site 63737017175 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 63737017176 substrate binding site [polypeptide binding]; other site 63737017177 dimer interface [polypeptide binding]; other site 63737017178 molecular chaperone DnaK; Provisional; Region: PRK13410 63737017179 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 63737017180 nucleotide binding site [chemical binding]; other site 63737017181 NEF interaction site [polypeptide binding]; other site 63737017182 SBD interface [polypeptide binding]; other site 63737017183 M28 Zn-Peptidases; Region: M28_like_1; cd05640 63737017184 Peptidase family M28; Region: Peptidase_M28; pfam04389 63737017185 metal binding site [ion binding]; metal-binding site 63737017186 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 63737017187 NADPH bind site [chemical binding]; other site 63737017188 putative FMN binding site [chemical binding]; other site 63737017189 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 63737017190 putative FMN binding site [chemical binding]; other site 63737017191 NADPH bind site [chemical binding]; other site 63737017192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737017193 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737017194 putative active site [active] 63737017195 heme pocket [chemical binding]; other site 63737017196 PAS domain; Region: PAS; smart00091 63737017197 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017198 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 63737017200 Histidine kinase; Region: HisKA_2; pfam07568 63737017201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017202 ATP binding site [chemical binding]; other site 63737017203 Mg2+ binding site [ion binding]; other site 63737017204 G-X-G motif; other site 63737017205 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737017206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017207 active site 63737017208 phosphorylation site [posttranslational modification] 63737017209 intermolecular recognition site; other site 63737017210 dimerization interface [polypeptide binding]; other site 63737017211 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737017212 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737017213 putative active site [active] 63737017214 heme pocket [chemical binding]; other site 63737017215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737017216 dimer interface [polypeptide binding]; other site 63737017217 phosphorylation site [posttranslational modification] 63737017218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017219 ATP binding site [chemical binding]; other site 63737017220 Mg2+ binding site [ion binding]; other site 63737017221 G-X-G motif; other site 63737017222 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 63737017223 aromatic amino acid transport protein; Region: araaP; TIGR00837 63737017224 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 63737017225 RNA/DNA hybrid binding site [nucleotide binding]; other site 63737017226 active site 63737017227 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 63737017228 active site 63737017229 Predicted membrane protein [Function unknown]; Region: COG2324 63737017230 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 63737017231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 63737017232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737017233 dimer interface [polypeptide binding]; other site 63737017234 conserved gate region; other site 63737017235 putative PBP binding loops; other site 63737017236 ABC-ATPase subunit interface; other site 63737017237 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737017238 putative active site [active] 63737017239 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 63737017240 putative binding surface; other site 63737017241 active site 63737017242 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 63737017243 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 63737017244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017245 ATP binding site [chemical binding]; other site 63737017246 Mg2+ binding site [ion binding]; other site 63737017247 G-X-G motif; other site 63737017248 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 63737017249 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737017250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017251 active site 63737017252 phosphorylation site [posttranslational modification] 63737017253 intermolecular recognition site; other site 63737017254 dimerization interface [polypeptide binding]; other site 63737017255 four helix bundle protein; Region: TIGR02436 63737017256 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017257 GAF domain; Region: GAF; pfam01590 63737017258 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017259 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017260 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017261 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017262 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017263 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 63737017265 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 63737017266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 63737017267 dimer interface [polypeptide binding]; other site 63737017268 putative CheW interface [polypeptide binding]; other site 63737017269 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 63737017270 Response regulator receiver domain; Region: Response_reg; pfam00072 63737017271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017272 active site 63737017273 phosphorylation site [posttranslational modification] 63737017274 intermolecular recognition site; other site 63737017275 dimerization interface [polypeptide binding]; other site 63737017276 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737017277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017278 active site 63737017279 phosphorylation site [posttranslational modification] 63737017280 intermolecular recognition site; other site 63737017281 dimerization interface [polypeptide binding]; other site 63737017282 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 63737017283 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 63737017284 putative active site [active] 63737017285 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 63737017286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 63737017287 Family of unknown function (DUF490); Region: DUF490; pfam04357 63737017288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737017289 dimer interface [polypeptide binding]; other site 63737017290 conserved gate region; other site 63737017291 ABC-ATPase subunit interface; other site 63737017292 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 63737017293 GIY-YIG motif/motif A; other site 63737017294 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 63737017295 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 63737017296 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 63737017297 Walker A/P-loop; other site 63737017298 ATP binding site [chemical binding]; other site 63737017299 Q-loop/lid; other site 63737017300 ABC transporter signature motif; other site 63737017301 Walker B; other site 63737017302 D-loop; other site 63737017303 H-loop/switch region; other site 63737017304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737017305 S-adenosylmethionine binding site [chemical binding]; other site 63737017306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737017307 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 63737017308 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 63737017309 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 63737017310 TrkA-N domain; Region: TrkA_N; pfam02254 63737017311 TrkA-C domain; Region: TrkA_C; pfam02080 63737017312 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 63737017313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737017314 binding surface 63737017315 TPR motif; other site 63737017316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737017317 binding surface 63737017318 TPR motif; other site 63737017319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737017320 binding surface 63737017321 TPR motif; other site 63737017322 Tetratricopeptide repeat; Region: TPR_17; pfam13431 63737017323 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 63737017324 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 63737017325 hypothetical protein; Reviewed; Region: PRK12497 63737017326 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737017327 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737017328 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737017329 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737017330 Bacterial SH3 domain; Region: SH3_3; pfam08239 63737017331 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 63737017332 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 63737017333 active site 63737017334 metal binding site [ion binding]; metal-binding site 63737017335 CTP synthetase; Validated; Region: pyrG; PRK05380 63737017336 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 63737017337 Catalytic site [active] 63737017338 active site 63737017339 UTP binding site [chemical binding]; other site 63737017340 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 63737017341 active site 63737017342 putative oxyanion hole; other site 63737017343 catalytic triad [active] 63737017344 agmatinase; Region: agmatinase; TIGR01230 63737017345 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 63737017346 putative active site [active] 63737017347 Mn binding site [ion binding]; other site 63737017348 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 63737017349 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 63737017350 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 63737017351 Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303 63737017352 inhibitor binding site; inhibition site 63737017353 catalytic motif [active] 63737017354 Catalytic residue [active] 63737017355 Active site flap [active] 63737017356 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737017357 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737017358 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 63737017359 Leucine-rich repeats; other site 63737017360 Leucine rich repeat; Region: LRR_8; pfam13855 63737017361 Substrate binding site [chemical binding]; other site 63737017362 Leucine rich repeat; Region: LRR_8; pfam13855 63737017363 Leucine rich repeat; Region: LRR_8; pfam13855 63737017364 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737017365 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737017366 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 63737017367 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737017368 G1 box; other site 63737017369 GTP/Mg2+ binding site [chemical binding]; other site 63737017370 G2 box; other site 63737017371 Switch I region; other site 63737017372 G3 box; other site 63737017373 Switch II region; other site 63737017374 G4 box; other site 63737017375 G5 box; other site 63737017376 TIR domain; Region: TIR_2; pfam13676 63737017377 Cache domain; Region: Cache_1; pfam02743 63737017378 HAMP domain; Region: HAMP; pfam00672 63737017379 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017380 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737017382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737017383 dimer interface [polypeptide binding]; other site 63737017384 phosphorylation site [posttranslational modification] 63737017385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017386 ATP binding site [chemical binding]; other site 63737017387 Mg2+ binding site [ion binding]; other site 63737017388 G-X-G motif; other site 63737017389 Uncharacterized conserved protein [Function unknown]; Region: COG4715 63737017390 SWIM zinc finger; Region: SWIM; pfam04434 63737017391 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 63737017392 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737017393 ATP binding site [chemical binding]; other site 63737017394 putative Mg++ binding site [ion binding]; other site 63737017395 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737017396 nucleotide binding region [chemical binding]; other site 63737017397 ATP-binding site [chemical binding]; other site 63737017398 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 63737017399 catalytic core [active] 63737017400 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 63737017401 catalytic core [active] 63737017402 dihydroorotase; Provisional; Region: PRK07369 63737017403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 63737017404 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 63737017405 active site 63737017406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737017407 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737017408 active site 63737017409 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 63737017410 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 63737017411 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 63737017412 putative NAD(P) binding site [chemical binding]; other site 63737017413 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 63737017414 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 63737017415 putative NAD(P) binding site [chemical binding]; other site 63737017416 putative active site [active] 63737017417 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 63737017418 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 63737017419 substrate binding pocket [chemical binding]; other site 63737017420 active site 63737017421 iron coordination sites [ion binding]; other site 63737017422 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 63737017423 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 63737017424 active site 63737017425 non-prolyl cis peptide bond; other site 63737017426 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 63737017427 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 63737017428 putative hydrolase; Provisional; Region: PRK11460 63737017429 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 63737017430 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 63737017431 Flavoprotein; Region: Flavoprotein; pfam02441 63737017432 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 63737017433 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 63737017434 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 63737017435 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 63737017436 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 63737017437 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 63737017438 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 63737017439 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 63737017440 Peptidase family M50; Region: Peptidase_M50; pfam02163 63737017441 active site 63737017442 putative substrate binding region [chemical binding]; other site 63737017443 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 63737017444 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737017445 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737017446 active site 63737017447 catalytic residues [active] 63737017448 DNA binding site [nucleotide binding] 63737017449 Int/Topo IB signature motif; other site 63737017450 Virulence-associated protein E; Region: VirE; pfam05272 63737017451 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 63737017452 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 63737017453 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 63737017454 Fasciclin domain; Region: Fasciclin; pfam02469 63737017455 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 63737017456 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 63737017457 active site 63737017458 homodimer interface [polypeptide binding]; other site 63737017459 catalytic site [active] 63737017460 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 63737017461 active site 63737017462 catalytic triad [active] 63737017463 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 63737017464 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 63737017465 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 63737017466 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 63737017467 Peptidase family M23; Region: Peptidase_M23; pfam01551 63737017468 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 63737017469 putative active site [active] 63737017470 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 63737017471 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 63737017472 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 63737017473 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 63737017474 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 63737017475 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 63737017476 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 63737017477 dimer interface [polypeptide binding]; other site 63737017478 decamer (pentamer of dimers) interface [polypeptide binding]; other site 63737017479 catalytic triad [active] 63737017480 peroxidatic and resolving cysteines [active] 63737017481 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 63737017482 putative catalytic residues [active] 63737017483 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737017484 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 63737017485 C-terminal domain interface [polypeptide binding]; other site 63737017486 GSH binding site (G-site) [chemical binding]; other site 63737017487 dimer interface [polypeptide binding]; other site 63737017488 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 63737017489 substrate binding pocket (H-site) [chemical binding]; other site 63737017490 N-terminal domain interface [polypeptide binding]; other site 63737017491 chaperone protein DnaJ; Provisional; Region: PRK14299 63737017492 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737017493 HSP70 interaction site [polypeptide binding]; other site 63737017494 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 63737017495 substrate binding site [polypeptide binding]; other site 63737017496 dimer interface [polypeptide binding]; other site 63737017497 AAA domain; Region: AAA_33; pfam13671 63737017498 AAA domain; Region: AAA_17; pfam13207 63737017499 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 63737017500 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 63737017501 ligand binding site; other site 63737017502 oligomer interface; other site 63737017503 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737017504 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 63737017505 dimer interface [polypeptide binding]; other site 63737017506 N-terminal domain interface [polypeptide binding]; other site 63737017507 sulfate 1 binding site; other site 63737017508 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 63737017509 putative active site [active] 63737017510 putative catalytic site [active] 63737017511 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 63737017512 AAA domain; Region: AAA_11; pfam13086 63737017513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737017514 Walker A motif; other site 63737017515 ATP binding site [chemical binding]; other site 63737017516 AAA domain; Region: AAA_11; pfam13086 63737017517 AAA domain; Region: AAA_12; pfam13087 63737017518 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 63737017519 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 63737017520 putative active site [active] 63737017521 Zn binding site [ion binding]; other site 63737017522 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 63737017523 Mechanosensitive ion channel; Region: MS_channel; pfam00924 63737017524 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 63737017525 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 63737017526 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737017527 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737017528 active site 63737017529 metal binding site [ion binding]; metal-binding site 63737017530 S-layer homology domain; Region: SLH; pfam00395 63737017531 S-layer homology domain; Region: SLH; pfam00395 63737017532 hydrolase, alpha/beta fold family protein; Region: PLN02824 63737017533 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 63737017534 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737017535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737017536 active site 63737017537 ATP binding site [chemical binding]; other site 63737017538 substrate binding site [chemical binding]; other site 63737017539 activation loop (A-loop); other site 63737017540 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 63737017541 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 63737017542 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 63737017543 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 63737017544 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 63737017545 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 63737017546 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737017547 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 63737017548 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 63737017549 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 63737017550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737017551 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737017552 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 63737017553 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737017554 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 63737017555 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 63737017556 Moco binding site; other site 63737017557 metal coordination site [ion binding]; other site 63737017558 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 63737017559 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 63737017560 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 63737017561 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 63737017562 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737017563 catalytic residues [active] 63737017564 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 63737017565 ribosomal protein L21; Region: rpl21; CHL00075 63737017566 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 63737017567 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 63737017568 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 63737017569 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 63737017570 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737017571 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737017572 Homeodomain-like domain; Region: HTH_23; pfam13384 63737017573 Winged helix-turn helix; Region: HTH_29; pfam13551 63737017574 Homeodomain-like domain; Region: HTH_32; pfam13565 63737017575 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737017576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 63737017577 PAS fold; Region: PAS_4; pfam08448 63737017578 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737017579 putative active site [active] 63737017580 heme pocket [chemical binding]; other site 63737017581 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017582 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017583 GAF domain; Region: GAF; pfam01590 63737017584 GAF domain; Region: GAF_2; pfam13185 63737017585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737017586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737017587 dimer interface [polypeptide binding]; other site 63737017588 phosphorylation site [posttranslational modification] 63737017589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017590 ATP binding site [chemical binding]; other site 63737017591 Mg2+ binding site [ion binding]; other site 63737017592 G-X-G motif; other site 63737017593 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737017594 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 63737017595 FAD binding domain; Region: FAD_binding_4; pfam01565 63737017596 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 63737017597 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 63737017598 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737017599 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 63737017600 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 63737017601 putative active site [active] 63737017602 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737017603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737017604 Walker A/P-loop; other site 63737017605 ATP binding site [chemical binding]; other site 63737017606 Q-loop/lid; other site 63737017607 ABC transporter signature motif; other site 63737017608 Walker B; other site 63737017609 D-loop; other site 63737017610 H-loop/switch region; other site 63737017611 hydrolase, alpha/beta fold family protein; Region: PLN02824 63737017612 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737017613 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737017614 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 63737017615 putative catalytic residue [active] 63737017616 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 63737017617 putative nucleotide binding site [chemical binding]; other site 63737017618 uridine monophosphate binding site [chemical binding]; other site 63737017619 homohexameric interface [polypeptide binding]; other site 63737017620 ribosome recycling factor; Reviewed; Region: frr; PRK00083 63737017621 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 63737017622 hinge region; other site 63737017623 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 63737017624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 63737017625 Walker A/P-loop; other site 63737017626 ATP binding site [chemical binding]; other site 63737017627 Q-loop/lid; other site 63737017628 ABC transporter signature motif; other site 63737017629 Walker B; other site 63737017630 D-loop; other site 63737017631 H-loop/switch region; other site 63737017632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 63737017633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 63737017634 Walker A/P-loop; other site 63737017635 ATP binding site [chemical binding]; other site 63737017636 Q-loop/lid; other site 63737017637 ABC transporter signature motif; other site 63737017638 Walker B; other site 63737017639 D-loop; other site 63737017640 H-loop/switch region; other site 63737017641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 63737017642 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737017643 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 63737017644 UreF; Region: UreF; pfam01730 63737017645 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 63737017646 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 63737017647 dimer interface [polypeptide binding]; other site 63737017648 catalytic residues [active] 63737017649 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 63737017650 AAA ATPase domain; Region: AAA_16; pfam13191 63737017651 WD40 repeats; Region: WD40; smart00320 63737017652 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737017653 WD domain, G-beta repeat; Region: WD40; pfam00400 63737017654 WD40 repeats; Region: WD40; smart00320 63737017655 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737017656 structural tetrad; other site 63737017657 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737017658 structural tetrad; other site 63737017659 PAS domain S-box; Region: sensory_box; TIGR00229 63737017660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737017661 putative active site [active] 63737017662 heme pocket [chemical binding]; other site 63737017663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737017664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737017665 dimer interface [polypeptide binding]; other site 63737017666 phosphorylation site [posttranslational modification] 63737017667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017668 ATP binding site [chemical binding]; other site 63737017669 Mg2+ binding site [ion binding]; other site 63737017670 G-X-G motif; other site 63737017671 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737017672 PAS domain; Region: PAS; smart00091 63737017673 PAS domain S-box; Region: sensory_box; TIGR00229 63737017674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737017675 putative active site [active] 63737017676 heme pocket [chemical binding]; other site 63737017677 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737017678 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737017679 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737017680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017681 ATP binding site [chemical binding]; other site 63737017682 Mg2+ binding site [ion binding]; other site 63737017683 G-X-G motif; other site 63737017684 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 63737017685 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 63737017686 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 63737017687 active site residue [active] 63737017688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 63737017689 flavodoxin FldA; Validated; Region: PRK09267 63737017690 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 63737017691 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 63737017692 active site 63737017693 Substrate binding site; other site 63737017694 Mg++ binding site; other site 63737017695 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737017696 putative trimer interface [polypeptide binding]; other site 63737017697 putative CoA binding site [chemical binding]; other site 63737017698 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 63737017699 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 63737017700 Predicted membrane protein [Function unknown]; Region: COG5305 63737017701 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 63737017702 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 63737017703 PDGLE domain; Region: PDGLE; pfam13190 63737017704 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 63737017705 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 63737017706 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 63737017707 Walker A/P-loop; other site 63737017708 ATP binding site [chemical binding]; other site 63737017709 Q-loop/lid; other site 63737017710 ABC transporter signature motif; other site 63737017711 Walker B; other site 63737017712 D-loop; other site 63737017713 H-loop/switch region; other site 63737017714 S-layer homology domain; Region: SLH; pfam00395 63737017715 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 63737017716 Predicted membrane protein [Function unknown]; Region: COG4330 63737017717 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 63737017718 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 63737017719 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 63737017720 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 63737017721 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 63737017722 MgtC family; Region: MgtC; pfam02308 63737017723 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 63737017724 recombination protein F; Reviewed; Region: recF; PRK00064 63737017725 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 63737017726 Walker A/P-loop; other site 63737017727 ATP binding site [chemical binding]; other site 63737017728 Q-loop/lid; other site 63737017729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737017730 ABC transporter signature motif; other site 63737017731 Walker B; other site 63737017732 D-loop; other site 63737017733 H-loop/switch region; other site 63737017734 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 63737017735 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 63737017736 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 63737017737 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 63737017738 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737017739 motif II; other site 63737017740 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 63737017741 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 63737017742 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 63737017743 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 63737017744 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 63737017745 active site 63737017746 substrate binding site [chemical binding]; other site 63737017747 metal binding site [ion binding]; metal-binding site 63737017748 Protein of unknown function (DUF433); Region: DUF433; pfam04255 63737017749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 63737017750 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 63737017751 Domain of unknown function DUF29; Region: DUF29; pfam01724 63737017752 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 63737017753 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737017754 putative active site [active] 63737017755 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 63737017756 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737017757 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 63737017758 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 63737017759 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 63737017760 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 63737017761 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 63737017762 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737017763 catalytic residues [active] 63737017764 Predicted membrane protein [Function unknown]; Region: COG4094 63737017765 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 63737017766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 63737017767 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 63737017768 putative dimerization interface [polypeptide binding]; other site 63737017769 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737017770 active site 63737017771 ATP binding site [chemical binding]; other site 63737017772 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737017773 substrate binding site [chemical binding]; other site 63737017774 activation loop (A-loop); other site 63737017775 PBP superfamily domain; Region: PBP_like_2; pfam12849 63737017776 TPR repeat; Region: TPR_11; pfam13414 63737017777 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 63737017778 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 63737017779 putative ligand binding site [chemical binding]; other site 63737017780 PBP superfamily domain; Region: PBP_like_2; cl17296 63737017781 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 63737017782 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 63737017783 putative switch regulator; other site 63737017784 non-specific DNA interactions [nucleotide binding]; other site 63737017785 DNA binding site [nucleotide binding] 63737017786 sequence specific DNA binding site [nucleotide binding]; other site 63737017787 putative cAMP binding site [chemical binding]; other site 63737017788 DALR anticodon binding domain; Region: DALR_1; smart00836 63737017789 anticodon binding site; other site 63737017790 tRNA binding surface [nucleotide binding]; other site 63737017791 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 63737017792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737017793 active site 63737017794 motif I; other site 63737017795 motif II; other site 63737017796 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737017797 DNA polymerase I; Provisional; Region: PRK05755 63737017798 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 63737017799 active site 63737017800 metal binding site 1 [ion binding]; metal-binding site 63737017801 putative 5' ssDNA interaction site; other site 63737017802 metal binding site 3; metal-binding site 63737017803 metal binding site 2 [ion binding]; metal-binding site 63737017804 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 63737017805 putative DNA binding site [nucleotide binding]; other site 63737017806 putative metal binding site [ion binding]; other site 63737017807 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 63737017808 active site 63737017809 catalytic site [active] 63737017810 substrate binding site [chemical binding]; other site 63737017811 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 63737017812 active site 63737017813 DNA binding site [nucleotide binding] 63737017814 catalytic site [active] 63737017815 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 63737017816 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 63737017817 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 63737017818 active site 63737017819 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 63737017820 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017821 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017822 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017823 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017824 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017825 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017826 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737017827 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 63737017828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737017829 dimer interface [polypeptide binding]; other site 63737017830 phosphorylation site [posttranslational modification] 63737017831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017832 ATP binding site [chemical binding]; other site 63737017833 Mg2+ binding site [ion binding]; other site 63737017834 G-X-G motif; other site 63737017835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737017836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017837 active site 63737017838 phosphorylation site [posttranslational modification] 63737017839 intermolecular recognition site; other site 63737017840 dimerization interface [polypeptide binding]; other site 63737017841 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737017842 DNA binding site [nucleotide binding] 63737017843 FO synthase subunit 2; Reviewed; Region: PRK07360 63737017844 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737017845 FeS/SAM binding site; other site 63737017846 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 63737017847 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 63737017848 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 63737017849 Ferritin-like domain; Region: Ferritin; pfam00210 63737017850 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 63737017851 dinuclear metal binding motif [ion binding]; other site 63737017852 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 63737017853 Periplasmic binding protein TroA_d. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141 63737017854 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 63737017855 putative ligand binding site [chemical binding]; other site 63737017856 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737017857 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 63737017858 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 63737017859 GTP binding site; other site 63737017860 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 63737017861 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 63737017862 catalytic residues [active] 63737017863 Clp protease; Region: CLP_protease; pfam00574 63737017864 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 63737017865 oligomer interface [polypeptide binding]; other site 63737017866 active site residues [active] 63737017867 Exoribonuclease R [Transcription]; Region: VacB; COG0557 63737017868 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 63737017869 RNB domain; Region: RNB; pfam00773 63737017870 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 63737017871 RNA binding site [nucleotide binding]; other site 63737017872 aromatic acid decarboxylase; Validated; Region: PRK05920 63737017873 Flavoprotein; Region: Flavoprotein; pfam02441 63737017874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 63737017875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737017876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737017877 dimerization interface [polypeptide binding]; other site 63737017878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737017879 dimer interface [polypeptide binding]; other site 63737017880 phosphorylation site [posttranslational modification] 63737017881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737017882 ATP binding site [chemical binding]; other site 63737017883 Mg2+ binding site [ion binding]; other site 63737017884 G-X-G motif; other site 63737017885 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737017886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737017887 active site 63737017888 phosphorylation site [posttranslational modification] 63737017889 intermolecular recognition site; other site 63737017890 dimerization interface [polypeptide binding]; other site 63737017891 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737017892 DNA binding site [nucleotide binding] 63737017893 Uncharacterized conserved protein [Function unknown]; Region: COG1432 63737017894 LabA_like proteins; Region: LabA; cd10911 63737017895 putative metal binding site [ion binding]; other site 63737017896 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 63737017897 Domain of unknown function (DUF3474); Region: DUF3474; pfam11960 63737017898 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 63737017899 putative di-iron ligands [ion binding]; other site 63737017900 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 63737017901 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 63737017902 putative di-iron ligands [ion binding]; other site 63737017903 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 63737017904 Fatty acid desaturase; Region: FA_desaturase; pfam00487 63737017905 Di-iron ligands [ion binding]; other site 63737017906 Aluminium resistance protein; Region: Alum_res; pfam06838 63737017907 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 63737017908 Cupin domain; Region: Cupin_2; pfam07883 63737017909 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 63737017910 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737017911 NAD binding site [chemical binding]; other site 63737017912 catalytic Zn binding site [ion binding]; other site 63737017913 structural Zn binding site [ion binding]; other site 63737017914 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 63737017915 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737017916 NAD binding site [chemical binding]; other site 63737017917 catalytic Zn binding site [ion binding]; other site 63737017918 structural Zn binding site [ion binding]; other site 63737017919 Predicted integral membrane protein [Function unknown]; Region: COG5637 63737017920 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 63737017921 putative hydrophobic ligand binding site [chemical binding]; other site 63737017922 intracellular protease, PfpI family; Region: PfpI; TIGR01382 63737017923 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 63737017924 proposed catalytic triad [active] 63737017925 conserved cys residue [active] 63737017926 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 63737017927 dinuclear metal binding motif [ion binding]; other site 63737017928 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 63737017929 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 63737017930 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 63737017931 FG-GAP repeat; Region: FG-GAP; cl15299 63737017932 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 63737017933 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 63737017934 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 63737017935 Active site cavity [active] 63737017936 catalytic acid [active] 63737017937 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 63737017938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 63737017939 active site 63737017940 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 63737017941 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737017942 dimerization interface [polypeptide binding]; other site 63737017943 putative DNA binding site [nucleotide binding]; other site 63737017944 putative Zn2+ binding site [ion binding]; other site 63737017945 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 63737017946 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 63737017947 catalytic residues [active] 63737017948 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 63737017949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737017950 NAD(P) binding site [chemical binding]; other site 63737017951 active site 63737017952 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 63737017953 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 63737017954 FMN binding site [chemical binding]; other site 63737017955 active site 63737017956 substrate binding site [chemical binding]; other site 63737017957 catalytic residue [active] 63737017958 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 63737017959 dimer interface [polypeptide binding]; other site 63737017960 FMN binding site [chemical binding]; other site 63737017961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737017962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737017963 putative substrate translocation pore; other site 63737017964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737017965 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 63737017966 NAD(P) binding site [chemical binding]; other site 63737017967 active site 63737017968 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737017969 S-adenosylmethionine binding site [chemical binding]; other site 63737017970 Methyltransferase domain; Region: Methyltransf_24; pfam13578 63737017971 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 63737017972 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 63737017973 C-terminal domain interface [polypeptide binding]; other site 63737017974 GSH binding site (G-site) [chemical binding]; other site 63737017975 dimer interface [polypeptide binding]; other site 63737017976 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 63737017977 N-terminal domain interface [polypeptide binding]; other site 63737017978 putative dimer interface [polypeptide binding]; other site 63737017979 active site 63737017980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 63737017981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 63737017982 putative acyl-acceptor binding pocket; other site 63737017983 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 63737017984 MoaE interaction surface [polypeptide binding]; other site 63737017985 MoeB interaction surface [polypeptide binding]; other site 63737017986 thiocarboxylated glycine; other site 63737017987 Putative restriction endonuclease; Region: Uma2; pfam05685 63737017988 putative active site [active] 63737017989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 63737017990 trimer interface [polypeptide binding]; other site 63737017991 active site 63737017992 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 63737017993 putative metal binding site [ion binding]; other site 63737017994 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 63737017995 Tetratricopeptide repeat; Region: TPR_6; pfam13174 63737017996 TPR repeat; Region: TPR_11; pfam13414 63737017997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737017998 binding surface 63737017999 TPR motif; other site 63737018000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737018001 acetyl-CoA synthetase; Provisional; Region: PRK00174 63737018002 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 63737018003 active site 63737018004 CoA binding site [chemical binding]; other site 63737018005 acyl-activating enzyme (AAE) consensus motif; other site 63737018006 AMP binding site [chemical binding]; other site 63737018007 acetate binding site [chemical binding]; other site 63737018008 Integral membrane protein TerC family; Region: TerC; cl10468 63737018009 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 63737018010 active site 63737018011 multimer interface [polypeptide binding]; other site 63737018012 arginine decarboxylase; Provisional; Region: PRK05354 63737018013 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 63737018014 dimer interface [polypeptide binding]; other site 63737018015 active site 63737018016 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 63737018017 catalytic residues [active] 63737018018 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 63737018019 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 63737018020 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 63737018021 active site 63737018022 Substrate binding site; other site 63737018023 Mg++ binding site; other site 63737018024 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 63737018025 putative trimer interface [polypeptide binding]; other site 63737018026 putative CoA binding site [chemical binding]; other site 63737018027 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 63737018028 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737018029 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737018030 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 63737018031 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 63737018032 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 63737018033 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 63737018034 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737018035 Predicted transcriptional regulators [Transcription]; Region: COG1733 63737018036 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 63737018037 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 63737018038 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 63737018039 binding surface 63737018040 Tetratricopeptide repeat; Region: TPR_16; pfam13432 63737018041 TPR motif; other site 63737018042 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 63737018043 feedback inhibition sensing region; other site 63737018044 homohexameric interface [polypeptide binding]; other site 63737018045 nucleotide binding site [chemical binding]; other site 63737018046 N-acetyl-L-glutamate binding site [chemical binding]; other site 63737018047 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737018048 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018049 shikimate kinase; Reviewed; Region: aroK; PRK00131 63737018050 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 63737018051 ADP binding site [chemical binding]; other site 63737018052 magnesium binding site [ion binding]; other site 63737018053 putative shikimate binding site; other site 63737018054 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 63737018055 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 63737018056 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 63737018057 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 63737018058 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737018059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 63737018060 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 63737018061 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 63737018062 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 63737018063 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 63737018064 active site 63737018065 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 63737018066 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 63737018067 active site 63737018068 catalytic site [active] 63737018069 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 63737018070 calcium/proton exchanger (cax); Region: cax; TIGR00378 63737018071 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 63737018072 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 63737018073 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737018074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737018075 active site 63737018076 ATP binding site [chemical binding]; other site 63737018077 substrate binding site [chemical binding]; other site 63737018078 activation loop (A-loop); other site 63737018079 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 63737018080 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 63737018081 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 63737018082 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 63737018083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 63737018084 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737018085 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737018086 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 63737018087 cofactor binding site; other site 63737018088 DNA binding site [nucleotide binding] 63737018089 substrate interaction site [chemical binding]; other site 63737018090 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 63737018091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737018092 Walker A motif; other site 63737018093 ATP binding site [chemical binding]; other site 63737018094 Zinc-finger associated domain (zf-AD); Region: zf-AD; cl07874 63737018095 HD domain; Region: HD_3; pfam13023 63737018096 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 63737018097 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 63737018098 purine monophosphate binding site [chemical binding]; other site 63737018099 dimer interface [polypeptide binding]; other site 63737018100 putative catalytic residues [active] 63737018101 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 63737018102 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 63737018103 helicase superfamily c-terminal domain; Region: HELICc; smart00490 63737018104 Ycf27; Reviewed; Region: orf27; CHL00148 63737018105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018106 active site 63737018107 phosphorylation site [posttranslational modification] 63737018108 intermolecular recognition site; other site 63737018109 dimerization interface [polypeptide binding]; other site 63737018110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737018111 DNA binding site [nucleotide binding] 63737018112 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737018113 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 63737018114 putative C-terminal domain interface [polypeptide binding]; other site 63737018115 putative GSH binding site (G-site) [chemical binding]; other site 63737018116 putative dimer interface [polypeptide binding]; other site 63737018117 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 63737018118 putative N-terminal domain interface [polypeptide binding]; other site 63737018119 putative dimer interface [polypeptide binding]; other site 63737018120 putative substrate binding pocket (H-site) [chemical binding]; other site 63737018121 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 63737018122 active site 63737018123 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 63737018124 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 63737018125 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 63737018126 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 63737018127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737018128 substrate binding pocket [chemical binding]; other site 63737018129 membrane-bound complex binding site; other site 63737018130 hinge residues; other site 63737018131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 63737018132 dimer interface [polypeptide binding]; other site 63737018133 conserved gate region; other site 63737018134 putative PBP binding loops; other site 63737018135 ABC-ATPase subunit interface; other site 63737018136 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 63737018137 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 63737018138 Walker A/P-loop; other site 63737018139 ATP binding site [chemical binding]; other site 63737018140 Q-loop/lid; other site 63737018141 ABC transporter signature motif; other site 63737018142 Walker B; other site 63737018143 D-loop; other site 63737018144 H-loop/switch region; other site 63737018145 Cytochrome P450; Region: p450; pfam00067 63737018146 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737018147 Predicted flavoprotein [General function prediction only]; Region: COG0431 63737018148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737018149 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 63737018150 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 63737018151 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 63737018152 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 63737018153 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 63737018154 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 63737018155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 63737018156 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737018157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 63737018158 Coenzyme A binding pocket [chemical binding]; other site 63737018159 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 63737018160 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 63737018161 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 63737018162 G1 box; other site 63737018163 GTP/Mg2+ binding site [chemical binding]; other site 63737018164 Switch I region; other site 63737018165 G2 box; other site 63737018166 Switch II region; other site 63737018167 G3 box; other site 63737018168 G4 box; other site 63737018169 G5 box; other site 63737018170 Domain of unknown function (DUF697); Region: DUF697; pfam05128 63737018171 4-coumarate--CoA ligase; Region: PLN02246 63737018172 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 63737018173 acyl-activating enzyme (AAE) consensus motif; other site 63737018174 active site 63737018175 putative CoA binding site [chemical binding]; other site 63737018176 AMP binding site [chemical binding]; other site 63737018177 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737018178 thioester reductase domain; Region: Thioester-redct; TIGR01746 63737018179 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 63737018180 putative NAD(P) binding site [chemical binding]; other site 63737018181 active site 63737018182 putative substrate binding site [chemical binding]; other site 63737018183 tellurium resistance terB-like protein, subgroup 1; Region: terB_like_1; cd07311 63737018184 dimer interface [polypeptide binding]; other site 63737018185 metal binding site [ion binding]; metal-binding site 63737018186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737018187 S-adenosylmethionine binding site [chemical binding]; other site 63737018188 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 63737018189 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737018190 FeS/SAM binding site; other site 63737018191 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 63737018192 tellurium resistance terB-like protein, subgroup 1; Region: terB_like_1; cd07311 63737018193 dimer interface [polypeptide binding]; other site 63737018194 metal binding site [ion binding]; metal-binding site 63737018195 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737018196 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737018197 active site 63737018198 ATP binding site [chemical binding]; other site 63737018199 substrate binding site [chemical binding]; other site 63737018200 activation loop (A-loop); other site 63737018201 Response regulator receiver domain; Region: Response_reg; pfam00072 63737018202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018203 active site 63737018204 phosphorylation site [posttranslational modification] 63737018205 intermolecular recognition site; other site 63737018206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737018207 dimerization interface [polypeptide binding]; other site 63737018208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 63737018209 dimer interface [polypeptide binding]; other site 63737018210 phosphorylation site [posttranslational modification] 63737018211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018212 ATP binding site [chemical binding]; other site 63737018213 Mg2+ binding site [ion binding]; other site 63737018214 G-X-G motif; other site 63737018215 Cache domain; Region: Cache_1; pfam02743 63737018216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018217 dimer interface [polypeptide binding]; other site 63737018218 phosphorylation site [posttranslational modification] 63737018219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018220 ATP binding site [chemical binding]; other site 63737018221 Mg2+ binding site [ion binding]; other site 63737018222 G-X-G motif; other site 63737018223 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737018224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018225 active site 63737018226 phosphorylation site [posttranslational modification] 63737018227 intermolecular recognition site; other site 63737018228 dimerization interface [polypeptide binding]; other site 63737018229 Protein kinase domain; Region: Pkinase; pfam00069 63737018230 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737018231 active site 63737018232 ATP binding site [chemical binding]; other site 63737018233 substrate binding site [chemical binding]; other site 63737018234 activation loop (A-loop); other site 63737018235 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018236 binding surface 63737018237 TPR motif; other site 63737018238 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 63737018239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018240 binding surface 63737018241 TPR motif; other site 63737018242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018243 binding surface 63737018244 TPR motif; other site 63737018245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018246 binding surface 63737018247 TPR motif; other site 63737018248 TPR repeat; Region: TPR_11; pfam13414 63737018249 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 63737018250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018251 PAS fold; Region: PAS_3; pfam08447 63737018252 putative active site [active] 63737018253 heme pocket [chemical binding]; other site 63737018254 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737018255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018256 putative active site [active] 63737018257 heme pocket [chemical binding]; other site 63737018258 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018259 putative active site [active] 63737018260 heme pocket [chemical binding]; other site 63737018261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737018262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018263 dimer interface [polypeptide binding]; other site 63737018264 phosphorylation site [posttranslational modification] 63737018265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018266 ATP binding site [chemical binding]; other site 63737018267 Mg2+ binding site [ion binding]; other site 63737018268 G-X-G motif; other site 63737018269 Response regulator receiver domain; Region: Response_reg; pfam00072 63737018270 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018271 active site 63737018272 phosphorylation site [posttranslational modification] 63737018273 intermolecular recognition site; other site 63737018274 dimerization interface [polypeptide binding]; other site 63737018275 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 63737018276 G1 box; other site 63737018277 GTP/Mg2+ binding site [chemical binding]; other site 63737018278 G2 box; other site 63737018279 Switch I region; other site 63737018280 G3 box; other site 63737018281 Switch II region; other site 63737018282 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 63737018283 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737018284 putative active site [active] 63737018285 hypothetical protein; Provisional; Region: PRK09256 63737018286 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 63737018287 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 63737018288 RNA binding surface [nucleotide binding]; other site 63737018289 DEAD-like helicases superfamily; Region: DEXDc; smart00487 63737018290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737018291 ATP binding site [chemical binding]; other site 63737018292 putative Mg++ binding site [ion binding]; other site 63737018293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737018294 nucleotide binding region [chemical binding]; other site 63737018295 ATP-binding site [chemical binding]; other site 63737018296 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 63737018297 MoxR-like ATPases [General function prediction only]; Region: COG0714 63737018298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737018299 Walker A motif; other site 63737018300 ATP binding site [chemical binding]; other site 63737018301 Walker B motif; other site 63737018302 arginine finger; other site 63737018303 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 63737018304 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 63737018305 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737018306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018307 active site 63737018308 phosphorylation site [posttranslational modification] 63737018309 intermolecular recognition site; other site 63737018310 dimerization interface [polypeptide binding]; other site 63737018311 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737018312 DNA binding site [nucleotide binding] 63737018313 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 63737018314 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 63737018315 GAF domain; Region: GAF; pfam01590 63737018316 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737018317 PAS fold; Region: PAS_4; pfam08448 63737018318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018319 putative active site [active] 63737018320 heme pocket [chemical binding]; other site 63737018321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018322 PAS fold; Region: PAS_3; pfam08447 63737018323 putative active site [active] 63737018324 heme pocket [chemical binding]; other site 63737018325 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737018326 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737018327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018328 dimer interface [polypeptide binding]; other site 63737018329 phosphorylation site [posttranslational modification] 63737018330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018331 ATP binding site [chemical binding]; other site 63737018332 Mg2+ binding site [ion binding]; other site 63737018333 G-X-G motif; other site 63737018334 Response regulator receiver domain; Region: Response_reg; pfam00072 63737018335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018336 active site 63737018337 phosphorylation site [posttranslational modification] 63737018338 intermolecular recognition site; other site 63737018339 dimerization interface [polypeptide binding]; other site 63737018340 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737018341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018342 active site 63737018343 phosphorylation site [posttranslational modification] 63737018344 intermolecular recognition site; other site 63737018345 dimerization interface [polypeptide binding]; other site 63737018346 PAS fold; Region: PAS_4; pfam08448 63737018347 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018348 putative active site [active] 63737018349 heme pocket [chemical binding]; other site 63737018350 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737018351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018352 putative active site [active] 63737018353 heme pocket [chemical binding]; other site 63737018354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018355 dimer interface [polypeptide binding]; other site 63737018356 phosphorylation site [posttranslational modification] 63737018357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018358 ATP binding site [chemical binding]; other site 63737018359 Mg2+ binding site [ion binding]; other site 63737018360 G-X-G motif; other site 63737018361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737018362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018363 active site 63737018364 phosphorylation site [posttranslational modification] 63737018365 intermolecular recognition site; other site 63737018366 dimerization interface [polypeptide binding]; other site 63737018367 phenylalanyl-tRNA synthetase beta chain; Provisional; Region: syfB; CHL00192 63737018368 GTP-binding protein YchF; Reviewed; Region: PRK09601 63737018369 YchF GTPase; Region: YchF; cd01900 63737018370 G1 box; other site 63737018371 GTP/Mg2+ binding site [chemical binding]; other site 63737018372 Switch I region; other site 63737018373 G2 box; other site 63737018374 Switch II region; other site 63737018375 G3 box; other site 63737018376 G4 box; other site 63737018377 G5 box; other site 63737018378 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 63737018379 Haemolytic domain; Region: Haemolytic; pfam01809 63737018380 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 63737018381 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737018382 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737018383 active site 63737018384 ATP binding site [chemical binding]; other site 63737018385 substrate binding site [chemical binding]; other site 63737018386 activation loop (A-loop); other site 63737018387 KWG Leptospira; Region: KWG; pfam07656 63737018388 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737018389 putative active site [active] 63737018390 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 63737018391 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 63737018392 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 63737018393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018394 Mg2+ binding site [ion binding]; other site 63737018395 G-X-G motif; other site 63737018396 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 63737018397 anchoring element; other site 63737018398 dimer interface [polypeptide binding]; other site 63737018399 ATP binding site [chemical binding]; other site 63737018400 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 63737018401 active site 63737018402 putative metal-binding site [ion binding]; other site 63737018403 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 63737018404 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 63737018405 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737018406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737018407 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737018408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737018409 DNA binding residues [nucleotide binding] 63737018410 light-harvesting-like protein 3; Provisional; Region: PLN00014 63737018411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737018412 Coenzyme A binding pocket [chemical binding]; other site 63737018413 DNA gyrase subunit A; Validated; Region: PRK05560 63737018414 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 63737018415 CAP-like domain; other site 63737018416 active site 63737018417 primary dimer interface [polypeptide binding]; other site 63737018418 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737018419 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737018420 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737018421 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 63737018422 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737018423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018424 active site 63737018425 phosphorylation site [posttranslational modification] 63737018426 intermolecular recognition site; other site 63737018427 dimerization interface [polypeptide binding]; other site 63737018428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018429 binding surface 63737018430 TPR motif; other site 63737018431 TPR repeat; Region: TPR_11; pfam13414 63737018432 TPR repeat; Region: TPR_11; pfam13414 63737018433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737018434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737018435 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737018436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737018437 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 63737018438 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737018439 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 63737018440 FtsX-like permease family; Region: FtsX; pfam02687 63737018441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 63737018442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 63737018443 Walker A/P-loop; other site 63737018444 ATP binding site [chemical binding]; other site 63737018445 Q-loop/lid; other site 63737018446 ABC transporter signature motif; other site 63737018447 Walker B; other site 63737018448 D-loop; other site 63737018449 H-loop/switch region; other site 63737018450 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 63737018451 Cupin domain; Region: Cupin_2; cl17218 63737018452 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 63737018453 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 63737018454 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737018455 Ligand Binding Site [chemical binding]; other site 63737018456 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 63737018457 Ligand Binding Site [chemical binding]; other site 63737018458 Methyltransferase domain; Region: Methyltransf_31; pfam13847 63737018459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737018460 S-adenosylmethionine binding site [chemical binding]; other site 63737018461 Methyltransferase domain; Region: Methyltransf_23; pfam13489 63737018462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737018463 S-adenosylmethionine binding site [chemical binding]; other site 63737018464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 63737018465 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 63737018466 active site 63737018467 metal binding site [ion binding]; metal-binding site 63737018468 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 63737018469 translation initiation factor 3; Provisional; Region: infC; CHL00199 63737018470 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 63737018471 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 63737018472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737018473 TLC ATP/ADP transporter; Region: TLC; cl03940 63737018474 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 63737018475 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 63737018476 TrkA-N domain; Region: TrkA_N; pfam02254 63737018477 TrkA-C domain; Region: TrkA_C; pfam02080 63737018478 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 63737018479 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 63737018480 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 63737018481 Predicted membrane protein [Function unknown]; Region: COG1808 63737018482 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 63737018483 hypothetical protein; Reviewed; Region: PRK00024 63737018484 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 63737018485 MPN+ (JAMM) motif; other site 63737018486 Zinc-binding site [ion binding]; other site 63737018487 phosphoribulokinase; Provisional; Region: PRK07429 63737018488 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 63737018489 active site 63737018490 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 63737018491 active site 63737018492 catalytic site [active] 63737018493 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 63737018494 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 63737018495 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 63737018496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737018497 putative substrate translocation pore; other site 63737018498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737018499 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 63737018500 FeS/SAM binding site; other site 63737018501 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 63737018502 AAA ATPase domain; Region: AAA_16; pfam13191 63737018503 AAA domain; Region: AAA_22; pfam13401 63737018504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018505 TPR motif; other site 63737018506 binding surface 63737018507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737018508 AAA domain; Region: AAA_22; pfam13401 63737018509 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737018510 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 63737018511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 63737018512 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 63737018513 acyl-activating enzyme (AAE) consensus motif; other site 63737018514 acyl-activating enzyme (AAE) consensus motif; other site 63737018515 putative AMP binding site [chemical binding]; other site 63737018516 putative active site [active] 63737018517 putative CoA binding site [chemical binding]; other site 63737018518 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 63737018519 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 63737018520 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 63737018521 E3 interaction surface; other site 63737018522 lipoyl attachment site [posttranslational modification]; other site 63737018523 e3 binding domain; Region: E3_binding; pfam02817 63737018524 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 63737018525 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737018526 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737018527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737018528 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 63737018529 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 63737018530 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 63737018531 protein-splicing catalytic site; other site 63737018532 thioester formation/cholesterol transfer; other site 63737018533 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 63737018534 protein-splicing catalytic site; other site 63737018535 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 63737018536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737018537 S-adenosylmethionine binding site [chemical binding]; other site 63737018538 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 63737018539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 63737018540 motif II; other site 63737018541 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 63737018542 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737018543 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 63737018544 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737018545 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 63737018546 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 63737018547 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 63737018548 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 63737018549 homodimer interface [polypeptide binding]; other site 63737018550 substrate-cofactor binding pocket; other site 63737018551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737018552 catalytic residue [active] 63737018553 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 63737018554 active site 63737018555 catalytic triad [active] 63737018556 oxyanion hole [active] 63737018557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737018558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018559 TPR motif; other site 63737018560 binding surface 63737018561 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737018562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737018563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018564 TPR motif; other site 63737018565 binding surface 63737018566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737018567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018568 binding surface 63737018569 TPR repeat; Region: TPR_11; pfam13414 63737018570 TPR motif; other site 63737018571 Predicted metal-binding protein [General function prediction only]; Region: COG3019 63737018572 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 63737018573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737018574 DNA polymerase III subunit delta'; Validated; Region: PRK07399 63737018575 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 63737018576 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 63737018577 active site 63737018578 metal binding site [ion binding]; metal-binding site 63737018579 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 63737018580 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 63737018581 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 63737018582 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 63737018583 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 63737018584 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 63737018585 EamA-like transporter family; Region: EamA; pfam00892 63737018586 EamA-like transporter family; Region: EamA; pfam00892 63737018587 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 63737018588 TM2 domain; Region: TM2; cl00984 63737018589 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 63737018590 diiron binding motif [ion binding]; other site 63737018591 Winged helix-turn helix; Region: HTH_29; pfam13551 63737018592 Homeodomain-like domain; Region: HTH_23; pfam13384 63737018593 Homeodomain-like domain; Region: HTH_32; pfam13565 63737018594 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 63737018595 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737018596 quinolinate synthetase; Provisional; Region: PRK09375 63737018597 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 63737018598 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 63737018599 putative active site [active] 63737018600 putative metal binding site [ion binding]; other site 63737018601 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 63737018602 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 63737018603 putative active site [active] 63737018604 homotetrameric interface [polypeptide binding]; other site 63737018605 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 63737018606 active site 63737018607 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 63737018608 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 63737018609 acyl-activating enzyme (AAE) consensus motif; other site 63737018610 putative AMP binding site [chemical binding]; other site 63737018611 putative active site [active] 63737018612 putative CoA binding site [chemical binding]; other site 63737018613 O-succinylbenzoate synthase; Provisional; Region: PRK02714 63737018614 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 63737018615 active site 63737018616 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 63737018617 UbiA prenyltransferase family; Region: UbiA; pfam01040 63737018618 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 63737018619 chorismate binding enzyme; Region: Chorismate_bind; cl10555 63737018620 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 63737018621 active site 63737018622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737018623 TPR motif; other site 63737018624 TPR repeat; Region: TPR_11; pfam13414 63737018625 binding surface 63737018626 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 63737018627 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 63737018628 putative catalytic cysteine [active] 63737018629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018630 PAS domain; Region: PAS_9; pfam13426 63737018631 putative active site [active] 63737018632 heme pocket [chemical binding]; other site 63737018633 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737018634 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737018635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737018636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018637 dimer interface [polypeptide binding]; other site 63737018638 phosphorylation site [posttranslational modification] 63737018639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018640 ATP binding site [chemical binding]; other site 63737018641 Mg2+ binding site [ion binding]; other site 63737018642 G-X-G motif; other site 63737018643 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737018644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737018645 active site 63737018646 phosphorylation site [posttranslational modification] 63737018647 intermolecular recognition site; other site 63737018648 dimerization interface [polypeptide binding]; other site 63737018649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737018650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 63737018651 substrate binding pocket [chemical binding]; other site 63737018652 Ion channel; Region: Ion_trans_2; pfam07885 63737018653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 63737018654 membrane-bound complex binding site; other site 63737018655 hinge residues; other site 63737018656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737018657 H+ Antiporter protein; Region: 2A0121; TIGR00900 63737018658 putative substrate translocation pore; other site 63737018659 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 63737018660 proposed catalytic triad [active] 63737018661 active site nucleophile [active] 63737018662 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737018663 active site 63737018664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737018665 catalytic tetrad [active] 63737018666 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 63737018667 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 63737018668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 63737018669 catalytic residue [active] 63737018670 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 63737018671 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 63737018672 catalytic triad [active] 63737018673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737018674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737018675 active site 63737018676 ATP binding site [chemical binding]; other site 63737018677 substrate binding site [chemical binding]; other site 63737018678 activation loop (A-loop); other site 63737018679 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737018680 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737018681 structural tetrad; other site 63737018682 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 63737018683 DNA photolyase; Region: DNA_photolyase; pfam00875 63737018684 precorrin-3B synthase; Region: CobG; TIGR02435 63737018685 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 63737018686 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 63737018687 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 63737018688 Precorrin-8X methylmutase; Region: CbiC; pfam02570 63737018689 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 63737018690 active site 63737018691 SAM binding site [chemical binding]; other site 63737018692 homodimer interface [polypeptide binding]; other site 63737018693 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737018694 dimerization interface [polypeptide binding]; other site 63737018695 putative DNA binding site [nucleotide binding]; other site 63737018696 putative Zn2+ binding site [ion binding]; other site 63737018697 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 63737018698 arsenical-resistance protein; Region: acr3; TIGR00832 63737018699 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 63737018700 Low molecular weight phosphatase family; Region: LMWPc; cd00115 63737018701 active site 63737018702 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 63737018703 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 63737018704 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 63737018705 PHP domain; Region: PHP; pfam02811 63737018706 active site 63737018707 Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150 63737018708 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 63737018709 ATP binding site [chemical binding]; other site 63737018710 dimerization interface [polypeptide binding]; other site 63737018711 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 63737018712 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 63737018713 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 63737018714 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 63737018715 Pantoate-beta-alanine ligase; Region: PanC; cd00560 63737018716 active site 63737018717 ATP-binding site [chemical binding]; other site 63737018718 pantoate-binding site; other site 63737018719 HXXH motif; other site 63737018720 AAA domain; Region: AAA_17; pfam13207 63737018721 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 63737018722 CMP-binding site; other site 63737018723 The sites determining sugar specificity; other site 63737018724 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 63737018725 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 63737018726 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 63737018727 glutaminase A; Region: Gln_ase; TIGR03814 63737018728 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 63737018729 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 63737018730 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 63737018731 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 63737018732 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 63737018733 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 63737018734 dimer interface [polypeptide binding]; other site 63737018735 decamer (pentamer of dimers) interface [polypeptide binding]; other site 63737018736 catalytic triad [active] 63737018737 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 63737018738 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 63737018739 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737018740 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 63737018741 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 63737018742 DXD motif; other site 63737018743 Cellulose synthase-like protein; Region: PLN02893 63737018744 PilZ domain; Region: PilZ; pfam07238 63737018745 Glycosyl hydrolase family 10; Region: Glyco_10; smart00633 63737018746 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 63737018747 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 63737018748 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 63737018749 metal ion-dependent adhesion site (MIDAS); other site 63737018750 Cache domain; Region: Cache_1; pfam02743 63737018751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737018752 dimerization interface [polypeptide binding]; other site 63737018753 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737018754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018755 dimer interface [polypeptide binding]; other site 63737018756 phosphorylation site [posttranslational modification] 63737018757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018758 ATP binding site [chemical binding]; other site 63737018759 Mg2+ binding site [ion binding]; other site 63737018760 G-X-G motif; other site 63737018761 Domain of Unknown Function with PDB structure (DUF3865); Region: DUF3865; pfam12981 63737018762 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 63737018763 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 63737018764 [2Fe-2S] cluster binding site [ion binding]; other site 63737018765 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 63737018766 alpha subunit interface [polypeptide binding]; other site 63737018767 active site 63737018768 substrate binding site [chemical binding]; other site 63737018769 Fe binding site [ion binding]; other site 63737018770 Archaeal ATPase; Region: Arch_ATPase; pfam01637 63737018771 Protein of unknown function (DUF1392); Region: DUF1392; pfam07154 63737018772 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 63737018773 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 63737018774 hydrophobic ligand binding site; other site 63737018775 Pheophorbide a oxygenase; Region: PaO; pfam08417 63737018776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 63737018777 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 63737018778 Dynamin family; Region: Dynamin_N; pfam00350 63737018779 G1 box; other site 63737018780 GTP/Mg2+ binding site [chemical binding]; other site 63737018781 G2 box; other site 63737018782 Switch I region; other site 63737018783 G3 box; other site 63737018784 Switch II region; other site 63737018785 G4 box; other site 63737018786 G5 box; other site 63737018787 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 63737018788 HSP70 interaction site [polypeptide binding]; other site 63737018789 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737018790 Dynamin family; Region: Dynamin_N; pfam00350 63737018791 G1 box; other site 63737018792 GTP/Mg2+ binding site [chemical binding]; other site 63737018793 G2 box; other site 63737018794 Switch I region; other site 63737018795 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 63737018796 G3 box; other site 63737018797 Switch II region; other site 63737018798 GTP/Mg2+ binding site [chemical binding]; other site 63737018799 G4 box; other site 63737018800 G5 box; other site 63737018801 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 63737018802 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 63737018803 dimer interface [polypeptide binding]; other site 63737018804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737018805 catalytic residue [active] 63737018806 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 63737018807 dimer interface [polypeptide binding]; other site 63737018808 [2Fe-2S] cluster binding site [ion binding]; other site 63737018809 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 63737018810 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 63737018811 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 63737018812 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 63737018813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 63737018814 DNA-binding site [nucleotide binding]; DNA binding site 63737018815 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 63737018816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737018817 homodimer interface [polypeptide binding]; other site 63737018818 catalytic residue [active] 63737018819 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 63737018820 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 63737018821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737018822 Coenzyme A binding pocket [chemical binding]; other site 63737018823 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 63737018824 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 63737018825 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 63737018826 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 63737018827 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 63737018828 Leucine rich repeat; Region: LRR_8; pfam13855 63737018829 Substrate binding site [chemical binding]; other site 63737018830 Leucine rich repeat; Region: LRR_8; pfam13855 63737018831 Leucine rich repeat; Region: LRR_8; pfam13855 63737018832 Leucine rich repeat; Region: LRR_8; pfam13855 63737018833 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 63737018834 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 63737018835 G1 box; other site 63737018836 GTP/Mg2+ binding site [chemical binding]; other site 63737018837 G2 box; other site 63737018838 Switch I region; other site 63737018839 G3 box; other site 63737018840 Switch II region; other site 63737018841 G4 box; other site 63737018842 G5 box; other site 63737018843 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 63737018844 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 63737018845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737018846 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 63737018847 putative active site [active] 63737018848 heme pocket [chemical binding]; other site 63737018849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737018850 dimer interface [polypeptide binding]; other site 63737018851 phosphorylation site [posttranslational modification] 63737018852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018853 ATP binding site [chemical binding]; other site 63737018854 Mg2+ binding site [ion binding]; other site 63737018855 G-X-G motif; other site 63737018856 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 63737018857 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 63737018858 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 63737018859 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 63737018860 thymidylate kinase; Validated; Region: tmk; PRK00698 63737018861 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 63737018862 TMP-binding site; other site 63737018863 ATP-binding site [chemical binding]; other site 63737018864 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 63737018865 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737018866 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737018867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737018868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737018869 DNA binding residues [nucleotide binding] 63737018870 dimerization interface [polypeptide binding]; other site 63737018871 Laminin B (Domain IV); Region: Laminin_B; cl02548 63737018872 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 63737018873 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 63737018874 active site 63737018875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 63737018876 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 63737018877 catalytic site [active] 63737018878 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 63737018879 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 63737018880 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737018881 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737018882 active site 63737018883 catalytic tetrad [active] 63737018884 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018885 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 63737018886 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018887 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018888 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018889 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018890 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018891 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 63737018892 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 63737018893 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 63737018894 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 63737018895 Domain of unknown function DUF20; Region: UPF0118; pfam01594 63737018896 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737018897 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737018898 active site 63737018899 ATP binding site [chemical binding]; other site 63737018900 substrate binding site [chemical binding]; other site 63737018901 activation loop (A-loop); other site 63737018902 AAA ATPase domain; Region: AAA_16; pfam13191 63737018903 Predicted ATPase [General function prediction only]; Region: COG3899 63737018904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737018905 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737018906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737018907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737018908 ATP binding site [chemical binding]; other site 63737018909 Mg2+ binding site [ion binding]; other site 63737018910 G-X-G motif; other site 63737018911 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 63737018912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737018913 NAD(P) binding site [chemical binding]; other site 63737018914 active site 63737018915 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737018916 active site 63737018917 catalytic tetrad [active] 63737018918 Lipoxygenase; Region: Lipoxygenase; pfam00305 63737018919 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 63737018920 Cytochrome P450; Region: p450; cl12078 63737018921 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 63737018922 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 63737018923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737018924 NAD(P) binding site [chemical binding]; other site 63737018925 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 63737018926 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 63737018927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 63737018928 active site 63737018929 chromosome segregation protein; Provisional; Region: PRK03918 63737018930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 63737018931 Probable transposase; Region: OrfB_IS605; pfam01385 63737018932 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 63737018933 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 63737018934 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 63737018935 TAP-like protein; Region: Abhydrolase_4; pfam08386 63737018936 Uncharacterized conserved protein [Function unknown]; Region: COG2128 63737018937 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 63737018938 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 63737018939 catalytic motif [active] 63737018940 Catalytic residue [active] 63737018941 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 63737018942 Acyltransferase family; Region: Acyl_transf_3; pfam01757 63737018943 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 63737018944 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 63737018945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737018946 S-adenosylmethionine binding site [chemical binding]; other site 63737018947 Macro domain, Appr-1"-pase family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase; cd02900 63737018948 ADP-ribose binding site [chemical binding]; other site 63737018949 putative active site [active] 63737018950 dimer interface [polypeptide binding]; other site 63737018951 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 63737018952 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 63737018953 ChaB; Region: ChaB; pfam06150 63737018954 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 63737018955 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 63737018956 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 63737018957 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 63737018958 S-layer homology domain; Region: SLH; pfam00395 63737018959 S-layer homology domain; Region: SLH; pfam00395 63737018960 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 63737018961 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737018962 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737018963 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737018964 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 63737018965 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 63737018966 NADP binding site [chemical binding]; other site 63737018967 homodimer interface [polypeptide binding]; other site 63737018968 active site 63737018969 substrate binding site [chemical binding]; other site 63737018970 Rubrerythrin [Energy production and conversion]; Region: COG1592 63737018971 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 63737018972 binuclear metal center [ion binding]; other site 63737018973 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 63737018974 iron binding site [ion binding]; other site 63737018975 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 63737018976 active site 63737018977 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 63737018978 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 63737018979 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 63737018980 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 63737018981 metal binding site 2 [ion binding]; metal-binding site 63737018982 putative DNA binding helix; other site 63737018983 metal binding site 1 [ion binding]; metal-binding site 63737018984 dimer interface [polypeptide binding]; other site 63737018985 structural Zn2+ binding site [ion binding]; other site 63737018986 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 63737018987 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 63737018988 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 63737018989 putative active site [active] 63737018990 catalytic triad [active] 63737018991 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 63737018992 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 63737018993 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737018994 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737018995 ligand binding site [chemical binding]; other site 63737018996 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 63737018997 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 63737018998 putative active site [active] 63737018999 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737019000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737019001 Walker A/P-loop; other site 63737019002 ATP binding site [chemical binding]; other site 63737019003 Q-loop/lid; other site 63737019004 ABC transporter signature motif; other site 63737019005 Walker B; other site 63737019006 D-loop; other site 63737019007 H-loop/switch region; other site 63737019008 Family description; Region: VCBS; pfam13517 63737019009 Family description; Region: VCBS; pfam13517 63737019010 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 63737019011 Family description; Region: VCBS; pfam13517 63737019012 Family description; Region: VCBS; pfam13517 63737019013 Family description; Region: VCBS; pfam13517 63737019014 Family description; Region: VCBS; pfam13517 63737019015 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 63737019016 Condensation domain; Region: Condensation; pfam00668 63737019017 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737019018 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737019019 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737019020 acyl-activating enzyme (AAE) consensus motif; other site 63737019021 AMP binding site [chemical binding]; other site 63737019022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019023 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737019024 Condensation domain; Region: Condensation; pfam00668 63737019025 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737019026 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737019027 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 63737019028 acyl-activating enzyme (AAE) consensus motif; other site 63737019029 AMP binding site [chemical binding]; other site 63737019030 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019031 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 63737019032 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 63737019033 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737019034 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 63737019035 active site 63737019036 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 63737019037 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737019038 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019039 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 63737019040 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 63737019041 inhibitor-cofactor binding pocket; inhibition site 63737019042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 63737019043 catalytic residue [active] 63737019044 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 63737019045 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 63737019046 acyl-activating enzyme (AAE) consensus motif; other site 63737019047 AMP binding site [chemical binding]; other site 63737019048 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019049 Sulfatase; Region: Sulfatase; cl17466 63737019050 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 63737019051 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 63737019052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 63737019053 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 63737019054 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 63737019055 putative active site [active] 63737019056 catalytic site [active] 63737019057 putative metal binding site [ion binding]; other site 63737019058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 63737019059 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737019060 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 63737019061 Phytase; Region: Phytase; cl17685 63737019062 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737019063 Circadian oscillating protein COP23; Region: COP23; pfam14218 63737019064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737019065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737019066 AAA domain; Region: AAA_22; pfam13401 63737019067 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019068 Integrase core domain; Region: rve; pfam00665 63737019069 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019070 Integrase core domain; Region: rve; pfam00665 63737019071 AAA domain; Region: AAA_22; pfam13401 63737019072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737019073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737019074 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 63737019075 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 63737019076 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 63737019077 active site 63737019078 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 63737019079 dimer interface [polypeptide binding]; other site 63737019080 ADP-ribose binding site [chemical binding]; other site 63737019081 active site 63737019082 nudix motif; other site 63737019083 metal binding site [ion binding]; metal-binding site 63737019084 TIR domain; Region: TIR_2; pfam13676 63737019085 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 63737019086 active site 63737019087 dimerization interface [polypeptide binding]; other site 63737019088 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 63737019089 nucleoside/Zn binding site; other site 63737019090 dimer interface [polypeptide binding]; other site 63737019091 catalytic motif [active] 63737019092 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 63737019093 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737019094 active site 63737019095 metal binding site [ion binding]; metal-binding site 63737019096 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 63737019097 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737019098 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737019099 TolA protein; Region: tolA_full; TIGR02794 63737019100 WD domain, G-beta repeat; Region: WD40; pfam00400 63737019101 WD domain, G-beta repeat; Region: WD40; pfam00400 63737019102 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019103 structural tetrad; other site 63737019104 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019105 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019106 structural tetrad; other site 63737019107 TIR domain; Region: TIR_2; pfam13676 63737019108 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 63737019109 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737019110 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737019111 AAA domain; Region: AAA_22; pfam13401 63737019112 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019113 Integrase core domain; Region: rve; pfam00665 63737019114 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 63737019115 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 63737019116 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 63737019117 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 63737019118 substrate binding site [chemical binding]; other site 63737019119 active site 63737019120 catalytic residues [active] 63737019121 heterodimer interface [polypeptide binding]; other site 63737019122 Protein kinase domain; Region: Pkinase; pfam00069 63737019123 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737019124 active site 63737019125 ATP binding site [chemical binding]; other site 63737019126 substrate binding site [chemical binding]; other site 63737019127 activation loop (A-loop); other site 63737019128 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 63737019129 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 63737019130 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 63737019131 TrkA-N domain; Region: TrkA_N; pfam02254 63737019132 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 63737019133 TrkA-N domain; Region: TrkA_N; pfam02254 63737019134 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 63737019135 active site 63737019136 catalytic residues [active] 63737019137 metal binding site [ion binding]; metal-binding site 63737019138 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 63737019139 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 63737019140 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 63737019141 protein binding site [polypeptide binding]; other site 63737019142 Response regulator receiver domain; Region: Response_reg; pfam00072 63737019143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737019144 active site 63737019145 phosphorylation site [posttranslational modification] 63737019146 intermolecular recognition site; other site 63737019147 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737019148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737019149 active site 63737019150 phosphorylation site [posttranslational modification] 63737019151 intermolecular recognition site; other site 63737019152 dimerization interface [polypeptide binding]; other site 63737019153 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 63737019154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 63737019155 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737019156 Walker A motif; other site 63737019157 ATP binding site [chemical binding]; other site 63737019158 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737019159 Mg binding site [ion binding]; other site 63737019160 nucleotide binding site [chemical binding]; other site 63737019161 putative protofilament interface [polypeptide binding]; other site 63737019162 Phage associated DNA primase [General function prediction only]; Region: COG3378 63737019163 D5 N terminal like; Region: D5_N; pfam08706 63737019164 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737019165 active site 63737019166 DNA binding site [nucleotide binding] 63737019167 Int/Topo IB signature motif; other site 63737019168 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 63737019169 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 63737019170 Antitoxin ParD; Region: ParD; pfam09386 63737019171 ParA-like protein; Provisional; Region: PHA02518 63737019172 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737019173 P-loop; other site 63737019174 Magnesium ion binding site [ion binding]; other site 63737019175 Antirestriction protein [General function prediction only]; Region: ArdA; COG4734 63737019176 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737019177 Mg binding site [ion binding]; other site 63737019178 nucleotide binding site [chemical binding]; other site 63737019179 putative protofilament interface [polypeptide binding]; other site 63737019180 TrwC relaxase; Region: TrwC; pfam08751 63737019181 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 63737019182 AAA domain; Region: AAA_30; pfam13604 63737019183 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 63737019184 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 63737019185 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 63737019186 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 63737019187 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 63737019188 CD20-like family; Region: CD20; pfam04103 63737019189 Domain of unknown function DUF87; Region: DUF87; pfam01935 63737019190 AAA-like domain; Region: AAA_10; pfam12846 63737019191 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737019192 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737019193 salt bridge; other site 63737019194 non-specific DNA binding site [nucleotide binding]; other site 63737019195 sequence-specific DNA binding site [nucleotide binding]; other site 63737019196 Double zinc ribbon; Region: DZR; pfam12773 63737019197 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 63737019198 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 63737019199 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737019200 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737019201 active site 63737019202 catalytic residues [active] 63737019203 DNA binding site [nucleotide binding] 63737019204 Int/Topo IB signature motif; other site 63737019205 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 63737019206 Eukaryotic and archaeal DNA primase small subunit; Region: DNA_primase_S; pfam01896 63737019207 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737019208 Mg binding site [ion binding]; other site 63737019209 nucleotide binding site [chemical binding]; other site 63737019210 putative protofilament interface [polypeptide binding]; other site 63737019211 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 63737019212 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 63737019213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737019214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737019215 non-specific DNA binding site [nucleotide binding]; other site 63737019216 salt bridge; other site 63737019217 sequence-specific DNA binding site [nucleotide binding]; other site 63737019218 Double zinc ribbon; Region: DZR; pfam12773 63737019219 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 63737019220 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737019221 active site 63737019222 DNA binding site [nucleotide binding] 63737019223 Int/Topo IB signature motif; other site 63737019224 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737019225 Glyco_18 domain; Region: Glyco_18; smart00636 63737019226 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 63737019227 active site 63737019228 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 63737019229 putative active site [active] 63737019230 catalytic site [active] 63737019231 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019232 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019233 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 63737019235 haemagglutination activity domain; Region: Haemagg_act; pfam05860 63737019236 AAA ATPase domain; Region: AAA_16; pfam13191 63737019237 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 63737019238 G1 box; other site 63737019239 GTP/Mg2+ binding site [chemical binding]; other site 63737019240 G2 box; other site 63737019241 Switch I region; other site 63737019242 G3 box; other site 63737019243 Switch II region; other site 63737019244 G4 box; other site 63737019245 G5 box; other site 63737019246 CHAT domain; Region: CHAT; cl17868 63737019247 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737019248 CHASE2 domain; Region: CHASE2; pfam05226 63737019249 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 63737019250 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 63737019251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737019252 DNA binding residues [nucleotide binding] 63737019253 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 63737019254 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737019255 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737019256 active site 63737019257 DNA binding site [nucleotide binding] 63737019258 Int/Topo IB signature motif; other site 63737019259 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 63737019260 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737019261 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737019262 P-loop; other site 63737019263 Magnesium ion binding site [ion binding]; other site 63737019264 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 63737019265 active site 63737019266 catalytic triad [active] 63737019267 oxyanion hole [active] 63737019268 Condensation domain; Region: Condensation; pfam00668 63737019269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737019270 Nonribosomal peptide synthase; Region: NRPS; pfam08415 63737019271 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 63737019272 acyl-activating enzyme (AAE) consensus motif; other site 63737019273 AMP binding site [chemical binding]; other site 63737019274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019275 Condensation domain; Region: Condensation; pfam00668 63737019276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737019277 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737019278 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 63737019279 acyl-activating enzyme (AAE) consensus motif; other site 63737019280 AMP binding site [chemical binding]; other site 63737019281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019282 Condensation domain; Region: Condensation; pfam00668 63737019283 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737019284 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737019285 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 63737019286 acyl-activating enzyme (AAE) consensus motif; other site 63737019287 AMP binding site [chemical binding]; other site 63737019288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019289 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 63737019290 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 63737019291 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 63737019292 acyl-activating enzyme (AAE) consensus motif; other site 63737019293 AMP binding site [chemical binding]; other site 63737019294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019295 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 63737019296 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 63737019297 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 63737019298 active site 63737019299 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 63737019300 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 63737019301 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 63737019302 KR domain; Region: KR; pfam08659 63737019303 putative NADP binding site [chemical binding]; other site 63737019304 active site 63737019305 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737019306 acyl-CoA synthetase; Validated; Region: PRK05850 63737019307 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 63737019308 acyl-activating enzyme (AAE) consensus motif; other site 63737019309 active site 63737019310 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 63737019311 Condensation domain; Region: Condensation; pfam00668 63737019312 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 63737019313 Nonribosomal peptide synthase; Region: NRPS; pfam08415 63737019314 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 63737019315 acyl-activating enzyme (AAE) consensus motif; other site 63737019316 AMP binding site [chemical binding]; other site 63737019317 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 63737019318 T5orf172 domain; Region: T5orf172; cl17462 63737019319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737019320 AAA domain; Region: AAA_22; pfam13401 63737019321 Walker A motif; other site 63737019322 ATP binding site [chemical binding]; other site 63737019323 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019324 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 63737019325 Integrase core domain; Region: rve; pfam00665 63737019326 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 63737019327 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019328 Integrase core domain; Region: rve; pfam00665 63737019329 AAA domain; Region: AAA_22; pfam13401 63737019330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737019331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737019332 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 63737019333 four helix bundle protein; Region: TIGR02436 63737019334 Domain of unknown function DUF87; Region: DUF87; pfam01935 63737019335 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737019336 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 63737019337 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 63737019338 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 63737019339 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 63737019340 Walker A/P-loop; other site 63737019341 ATP binding site [chemical binding]; other site 63737019342 Q-loop/lid; other site 63737019343 ABC transporter signature motif; other site 63737019344 Walker B; other site 63737019345 D-loop; other site 63737019346 H-loop/switch region; other site 63737019347 AIPR protein; Region: AIPR; pfam10592 63737019348 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737019349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737019350 salt bridge; other site 63737019351 non-specific DNA binding site [nucleotide binding]; other site 63737019352 sequence-specific DNA binding site [nucleotide binding]; other site 63737019353 Double zinc ribbon; Region: DZR; pfam12773 63737019354 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 63737019355 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 63737019356 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737019357 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737019358 active site 63737019359 catalytic residues [active] 63737019360 DNA binding site [nucleotide binding] 63737019361 Int/Topo IB signature motif; other site 63737019362 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 63737019363 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 63737019364 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 63737019365 AAA domain; Region: AAA_30; pfam13604 63737019366 Family description; Region: UvrD_C_2; pfam13538 63737019367 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737019368 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737019369 P-loop; other site 63737019370 Magnesium ion binding site [ion binding]; other site 63737019371 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737019372 Magnesium ion binding site [ion binding]; other site 63737019373 ParB-like nuclease domain; Region: ParBc; pfam02195 63737019374 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 63737019375 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737019376 Mg binding site [ion binding]; other site 63737019377 nucleotide binding site [chemical binding]; other site 63737019378 putative protofilament interface [polypeptide binding]; other site 63737019379 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 63737019380 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 63737019381 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737019382 nucleotide binding site [chemical binding]; other site 63737019383 putative protofilament interface [polypeptide binding]; other site 63737019384 TrwC relaxase; Region: TrwC; pfam08751 63737019385 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 63737019386 AAA domain; Region: AAA_30; pfam13604 63737019387 Family description; Region: UvrD_C_2; pfam13538 63737019388 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 63737019389 Restriction endonuclease; Region: Mrr_cat; pfam04471 63737019390 Prominin; Region: Prominin; pfam05478 63737019391 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 63737019392 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 63737019393 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 63737019394 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 63737019395 AAA-like domain; Region: AAA_10; pfam12846 63737019396 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 63737019397 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737019398 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737019399 active site 63737019400 catalytic residues [active] 63737019401 DNA binding site [nucleotide binding] 63737019402 Int/Topo IB signature motif; other site 63737019403 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 63737019404 active site 63737019405 metal binding site [ion binding]; metal-binding site 63737019406 interdomain interaction site; other site 63737019407 AAA domain; Region: AAA_22; pfam13401 63737019408 AAA ATPase domain; Region: AAA_16; pfam13191 63737019409 Walker A motif; other site 63737019410 ATP binding site [chemical binding]; other site 63737019411 Walker B motif; other site 63737019412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737019413 active site 63737019414 substrate binding site [chemical binding]; other site 63737019415 ATP binding site [chemical binding]; other site 63737019416 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 63737019417 activation loop (A-loop); other site 63737019418 TPR repeat; Region: TPR_11; pfam13414 63737019419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019420 binding surface 63737019421 TPR motif; other site 63737019422 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019423 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019424 binding surface 63737019425 TPR motif; other site 63737019426 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019428 binding surface 63737019429 TPR motif; other site 63737019430 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 63737019431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 63737019432 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737019433 haemagglutination activity domain; Region: Haemagg_act; pfam05860 63737019434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737019435 S-adenosylmethionine binding site [chemical binding]; other site 63737019436 Caspase domain; Region: Peptidase_C14; pfam00656 63737019437 CHAT domain; Region: CHAT; pfam12770 63737019438 TPR repeat; Region: TPR_11; pfam13414 63737019439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019440 binding surface 63737019441 TPR motif; other site 63737019442 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019445 binding surface 63737019446 TPR motif; other site 63737019447 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019449 binding surface 63737019450 TPR motif; other site 63737019451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019454 binding surface 63737019455 TPR motif; other site 63737019456 CHAT domain; Region: CHAT; pfam12770 63737019457 Homeodomain-like domain; Region: HTH_23; pfam13384 63737019458 Winged helix-turn helix; Region: HTH_29; pfam13551 63737019459 Homeodomain-like domain; Region: HTH_32; pfam13565 63737019460 Winged helix-turn helix; Region: HTH_33; pfam13592 63737019461 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737019462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 63737019463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 63737019464 active site 63737019465 phosphorylation site [posttranslational modification] 63737019466 intermolecular recognition site; other site 63737019467 dimerization interface [polypeptide binding]; other site 63737019468 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 63737019469 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737019470 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 63737019471 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 63737019472 active site 63737019473 zinc binding site [ion binding]; other site 63737019474 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 63737019475 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 63737019476 Coenzyme A binding pocket [chemical binding]; other site 63737019477 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 63737019478 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737019479 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 63737019480 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 63737019481 putative active site [active] 63737019482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737019483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737019484 Walker A/P-loop; other site 63737019485 ATP binding site [chemical binding]; other site 63737019486 Q-loop/lid; other site 63737019487 ABC transporter signature motif; other site 63737019488 Walker B; other site 63737019489 D-loop; other site 63737019490 H-loop/switch region; other site 63737019491 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 63737019492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737019493 Walker A/P-loop; other site 63737019494 ATP binding site [chemical binding]; other site 63737019495 Q-loop/lid; other site 63737019496 ABC transporter signature motif; other site 63737019497 Walker B; other site 63737019498 D-loop; other site 63737019499 H-loop/switch region; other site 63737019500 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 63737019501 TPR repeat; Region: TPR_11; pfam13414 63737019502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019503 binding surface 63737019504 TPR motif; other site 63737019505 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019507 binding surface 63737019508 TPR motif; other site 63737019509 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019511 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019512 CHAT domain; Region: CHAT; pfam12770 63737019513 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737019514 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737019515 CHAT domain; Region: CHAT; cl17868 63737019516 CHASE2 domain; Region: CHASE2; pfam05226 63737019517 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737019518 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019519 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019521 binding surface 63737019522 TPR motif; other site 63737019523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019525 binding surface 63737019526 TPR motif; other site 63737019527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019529 binding surface 63737019530 TPR motif; other site 63737019531 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019532 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019533 binding surface 63737019534 TPR motif; other site 63737019535 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019536 binding surface 63737019537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019538 TPR motif; other site 63737019539 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019540 CHAT domain; Region: CHAT; pfam12770 63737019541 CHAT domain; Region: CHAT; pfam12770 63737019542 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019543 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019544 structural tetrad; other site 63737019545 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019546 structural tetrad; other site 63737019547 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019548 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019549 structural tetrad; other site 63737019550 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019551 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019552 structural tetrad; other site 63737019553 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019554 structural tetrad; other site 63737019555 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019557 binding surface 63737019558 TPR motif; other site 63737019559 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019562 binding surface 63737019563 TPR motif; other site 63737019564 TPR repeat; Region: TPR_11; pfam13414 63737019565 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019567 binding surface 63737019568 TPR motif; other site 63737019569 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019570 CHAT domain; Region: CHAT; pfam12770 63737019571 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 63737019572 active site 63737019573 catalytic residues [active] 63737019574 TPR repeat; Region: TPR_11; pfam13414 63737019575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019576 binding surface 63737019577 TPR motif; other site 63737019578 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019581 binding surface 63737019582 TPR motif; other site 63737019583 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019585 TPR motif; other site 63737019586 binding surface 63737019587 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019588 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019589 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019591 binding surface 63737019592 TPR motif; other site 63737019593 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019594 binding surface 63737019595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019596 TPR motif; other site 63737019597 CHAT domain; Region: CHAT; pfam12770 63737019598 Caspase domain; Region: Peptidase_C14; pfam00656 63737019599 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 63737019600 PBP superfamily domain; Region: PBP_like_2; pfam12849 63737019601 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 63737019602 metal ion-dependent adhesion site (MIDAS); other site 63737019603 Tubulin like; Region: Tubulin_2; pfam13809 63737019604 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 63737019605 Double zinc ribbon; Region: DZR; pfam12773 63737019606 TPR repeat; Region: TPR_11; pfam13414 63737019607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019608 binding surface 63737019609 TPR motif; other site 63737019610 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737019611 putative active site [active] 63737019612 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019614 binding surface 63737019615 TPR motif; other site 63737019616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019618 binding surface 63737019619 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019620 TPR motif; other site 63737019621 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019623 Tetratricopeptide repeat; Region: TPR_10; pfam13374 63737019624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019625 binding surface 63737019626 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019627 TPR motif; other site 63737019628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019630 binding surface 63737019631 TPR motif; other site 63737019632 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019634 binding surface 63737019635 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019636 TPR motif; other site 63737019637 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019638 CHAT domain; Region: CHAT; pfam12770 63737019639 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019641 binding surface 63737019642 TPR motif; other site 63737019643 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019645 binding surface 63737019646 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019647 TPR motif; other site 63737019648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019649 binding surface 63737019650 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019651 TPR motif; other site 63737019652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019654 CHAT domain; Region: CHAT; pfam12770 63737019655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019657 binding surface 63737019658 TPR motif; other site 63737019659 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019660 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019661 TPR motif; other site 63737019662 binding surface 63737019663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019664 TPR motif; other site 63737019665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019666 binding surface 63737019667 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019669 binding surface 63737019670 TPR motif; other site 63737019671 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019673 CHAT domain; Region: CHAT; pfam12770 63737019674 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 63737019675 four helix bundle protein; Region: TIGR02436 63737019676 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737019677 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 63737019678 active site 63737019679 DNA binding site [nucleotide binding] 63737019680 Int/Topo IB signature motif; other site 63737019681 XisI protein; Region: XisI; pfam08869 63737019682 XisH protein; Region: XisH; pfam08814 63737019683 hypothetical protein; Reviewed; Region: PRK12275 63737019684 four helix bundle protein; Region: TIGR02436 63737019685 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019686 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 63737019687 Integrase core domain; Region: rve; pfam00665 63737019688 AAA domain; Region: AAA_22; pfam13401 63737019689 AAA ATPase domain; Region: AAA_16; pfam13191 63737019690 TniQ; Region: TniQ; pfam06527 63737019691 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019692 Integrase core domain; Region: rve; pfam00665 63737019693 AAA domain; Region: AAA_22; pfam13401 63737019694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737019695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737019696 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 63737019697 Response regulator receiver domain; Region: Response_reg; pfam00072 63737019698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737019699 active site 63737019700 phosphorylation site [posttranslational modification] 63737019701 intermolecular recognition site; other site 63737019702 dimerization interface [polypeptide binding]; other site 63737019703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737019704 dimer interface [polypeptide binding]; other site 63737019705 phosphorylation site [posttranslational modification] 63737019706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737019707 ATP binding site [chemical binding]; other site 63737019708 Mg2+ binding site [ion binding]; other site 63737019709 G-X-G motif; other site 63737019710 CHASE3 domain; Region: CHASE3; cl05000 63737019711 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 63737019712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019713 putative active site [active] 63737019714 heme pocket [chemical binding]; other site 63737019715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737019716 dimer interface [polypeptide binding]; other site 63737019717 phosphorylation site [posttranslational modification] 63737019718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737019719 ATP binding site [chemical binding]; other site 63737019720 Mg2+ binding site [ion binding]; other site 63737019721 G-X-G motif; other site 63737019722 Response regulator receiver domain; Region: Response_reg; pfam00072 63737019723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737019724 active site 63737019725 phosphorylation site [posttranslational modification] 63737019726 intermolecular recognition site; other site 63737019727 dimerization interface [polypeptide binding]; other site 63737019728 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 63737019729 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 63737019730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019731 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 63737019732 putative active site [active] 63737019733 heme pocket [chemical binding]; other site 63737019734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019735 putative active site [active] 63737019736 heme pocket [chemical binding]; other site 63737019737 PAS domain S-box; Region: sensory_box; TIGR00229 63737019738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019739 putative active site [active] 63737019740 heme pocket [chemical binding]; other site 63737019741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737019742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737019743 ATP binding site [chemical binding]; other site 63737019744 Mg2+ binding site [ion binding]; other site 63737019745 G-X-G motif; other site 63737019746 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 63737019747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737019748 metal binding site [ion binding]; metal-binding site 63737019749 active site 63737019750 I-site; other site 63737019751 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737019752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 63737019753 dimerization interface [polypeptide binding]; other site 63737019754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737019755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737019756 ATP binding site [chemical binding]; other site 63737019757 Mg2+ binding site [ion binding]; other site 63737019758 G-X-G motif; other site 63737019759 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737019760 GAF domain; Region: GAF; pfam01590 63737019761 Phytochrome region; Region: PHY; pfam00360 63737019762 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737019763 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 63737019764 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737019765 GAF domain; Region: GAF; pfam01590 63737019766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737019767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737019768 dimer interface [polypeptide binding]; other site 63737019769 phosphorylation site [posttranslational modification] 63737019770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737019771 ATP binding site [chemical binding]; other site 63737019772 Mg2+ binding site [ion binding]; other site 63737019773 G-X-G motif; other site 63737019774 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 63737019775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019776 putative active site [active] 63737019777 heme pocket [chemical binding]; other site 63737019778 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019779 putative active site [active] 63737019780 heme pocket [chemical binding]; other site 63737019781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737019782 putative active site [active] 63737019783 heme pocket [chemical binding]; other site 63737019784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 63737019785 metal binding site [ion binding]; metal-binding site 63737019786 active site 63737019787 I-site; other site 63737019788 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 63737019789 Protein of unknown function (DUF1392); Region: DUF1392; pfam07154 63737019790 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 63737019791 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 63737019792 cofactor binding site; other site 63737019793 DNA binding site [nucleotide binding] 63737019794 substrate interaction site [chemical binding]; other site 63737019795 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 63737019796 replicative DNA helicase; Region: DnaB; TIGR00665 63737019797 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 63737019798 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 63737019799 Walker A motif; other site 63737019800 ATP binding site [chemical binding]; other site 63737019801 Walker B motif; other site 63737019802 DNA binding loops [nucleotide binding] 63737019803 Helix-turn-helix domain; Region: HTH_36; pfam13730 63737019804 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 63737019805 KilA-N domain; Region: KilA-N; pfam04383 63737019806 Protein of unknown function (DUF1392); Region: DUF1392; pfam07154 63737019807 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 63737019808 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019809 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019810 structural tetrad; other site 63737019811 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019812 structural tetrad; other site 63737019813 Uncharacterized conserved protein [Function unknown]; Region: COG3391 63737019814 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019815 structural tetrad; other site 63737019816 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019817 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 63737019818 structural tetrad; other site 63737019819 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737019820 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737019821 structural tetrad; other site 63737019822 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019824 binding surface 63737019825 TPR motif; other site 63737019826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019827 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019829 binding surface 63737019830 TPR motif; other site 63737019831 Tetratricopeptide repeat; Region: TPR_12; pfam13424 63737019832 CHAT domain; Region: CHAT; pfam12770 63737019833 CHAT domain; Region: CHAT; pfam12770 63737019834 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 63737019835 CHASE2 domain; Region: CHASE2; pfam05226 63737019836 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 63737019837 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737019838 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 63737019839 C-terminal domain interface [polypeptide binding]; other site 63737019840 GSH binding site (G-site) [chemical binding]; other site 63737019841 dimer interface [polypeptide binding]; other site 63737019842 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 63737019843 N-terminal domain interface [polypeptide binding]; other site 63737019844 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 63737019845 putative deacylase active site [active] 63737019846 Transcriptional regulators [Transcription]; Region: MarR; COG1846 63737019847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737019848 putative Zn2+ binding site [ion binding]; other site 63737019849 putative DNA binding site [nucleotide binding]; other site 63737019850 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 63737019851 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 63737019852 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 63737019853 N-terminal domain interface [polypeptide binding]; other site 63737019854 dimer interface [polypeptide binding]; other site 63737019855 substrate binding pocket (H-site) [chemical binding]; other site 63737019856 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 63737019857 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 63737019858 4Fe-4S binding domain; Region: Fer4; pfam00037 63737019859 SCP-2 sterol transfer family; Region: SCP2; pfam02036 63737019860 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 63737019861 DDE superfamily endonuclease; Region: DDE_5; cl17874 63737019862 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 63737019863 active site 63737019864 substrate binding site [chemical binding]; other site 63737019865 catalytic site [active] 63737019866 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 63737019867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737019868 ATP binding site [chemical binding]; other site 63737019869 putative Mg++ binding site [ion binding]; other site 63737019870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737019871 nucleotide binding region [chemical binding]; other site 63737019872 ATP-binding site [chemical binding]; other site 63737019873 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 63737019874 Part of AAA domain; Region: AAA_19; pfam13245 63737019875 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 63737019876 Family description; Region: UvrD_C_2; pfam13538 63737019877 Staphylococcal nuclease homologues; Region: SNc; smart00318 63737019878 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 63737019879 Catalytic site; other site 63737019880 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 63737019881 active site 63737019882 thiamine phosphate binding site [chemical binding]; other site 63737019883 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 63737019884 active site 63737019885 Zn binding site [ion binding]; other site 63737019886 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 63737019887 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 63737019888 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 63737019889 active site 63737019890 substrate binding site [chemical binding]; other site 63737019891 Mg2+ binding site [ion binding]; other site 63737019892 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 63737019893 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 63737019894 Prostaglandin dehydrogenases; Region: PGDH; cd05288 63737019895 NAD(P) binding site [chemical binding]; other site 63737019896 substrate binding site [chemical binding]; other site 63737019897 dimer interface [polypeptide binding]; other site 63737019898 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 63737019899 HEAT repeats; Region: HEAT_2; pfam13646 63737019900 protein binding surface [polypeptide binding]; other site 63737019901 AAA ATPase domain; Region: AAA_16; pfam13191 63737019902 NACHT domain; Region: NACHT; pfam05729 63737019903 HEAT repeats; Region: HEAT_2; pfam13646 63737019904 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737019905 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737019906 DDE superfamily endonuclease; Region: DDE_5; cl17874 63737019907 short chain dehydrogenase; Validated; Region: PRK08264 63737019908 classical (c) SDR, subgroup 7; Region: SDR_c7; cd05354 63737019909 putative NAD(P) binding site [chemical binding]; other site 63737019910 active site 63737019911 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 63737019912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 63737019913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 63737019914 AAA domain; Region: AAA_22; pfam13401 63737019915 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 63737019916 Integrase core domain; Region: rve; pfam00665 63737019917 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737019918 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737019919 Uncharacterized conserved protein [Function unknown]; Region: COG1262 63737019920 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 63737019921 ERF superfamily; Region: ERF; pfam04404 63737019922 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 63737019923 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737019924 DNA photolyase; Region: DNA_photolyase; pfam00875 63737019925 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 63737019926 Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922 63737019927 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 63737019928 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 63737019929 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 63737019930 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 63737019931 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 63737019932 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 63737019933 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 63737019934 active site 63737019935 catalytic tetrad [active] 63737019936 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 63737019937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737019938 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 63737019939 Walker A motif; other site 63737019940 ATP binding site [chemical binding]; other site 63737019941 Walker B motif; other site 63737019942 High-affinity nickel-transport protein; Region: NicO; cl00964 63737019943 TPR repeat; Region: TPR_11; pfam13414 63737019944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019945 TPR motif; other site 63737019946 binding surface 63737019947 TPR repeat; Region: TPR_11; pfam13414 63737019948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737019949 TPR motif; other site 63737019950 binding surface 63737019951 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 63737019952 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737019953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737019954 non-specific DNA binding site [nucleotide binding]; other site 63737019955 salt bridge; other site 63737019956 sequence-specific DNA binding site [nucleotide binding]; other site 63737019957 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 63737019958 putative active site [active] 63737019959 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 63737019960 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 63737019961 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 63737019962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737019963 Walker A motif; other site 63737019964 ATP binding site [chemical binding]; other site 63737019965 Walker B motif; other site 63737019966 arginine finger; other site 63737019967 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 63737019968 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737019969 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737019970 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 63737019971 CHAT domain; Region: CHAT; pfam12770 63737019972 AAA ATPase domain; Region: AAA_16; pfam13191 63737019973 GUN4-like; Region: GUN4; pfam05419 63737019974 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 63737019975 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 63737019976 Divergent AAA domain; Region: AAA_4; pfam04326 63737019977 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 63737019978 PLD-like domain; Region: PLDc_2; pfam13091 63737019979 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 63737019980 putative homodimer interface [polypeptide binding]; other site 63737019981 putative active site [active] 63737019982 catalytic site [active] 63737019983 DEAD-like helicases superfamily; Region: DEXDc; smart00487 63737019984 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 63737019985 putative Mg++ binding site [ion binding]; other site 63737019986 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 63737019987 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737019988 nucleotide binding region [chemical binding]; other site 63737019989 ATP-binding site [chemical binding]; other site 63737019990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737019991 non-specific DNA binding site [nucleotide binding]; other site 63737019992 salt bridge; other site 63737019993 sequence-specific DNA binding site [nucleotide binding]; other site 63737019994 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737019995 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737019996 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737019997 P-loop; other site 63737019998 Magnesium ion binding site [ion binding]; other site 63737019999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737020000 Magnesium ion binding site [ion binding]; other site 63737020001 ParB-like nuclease domain; Region: ParB; smart00470 63737020002 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 63737020003 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 63737020004 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 63737020005 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 63737020006 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 63737020007 DNA binding residues [nucleotide binding] 63737020008 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 63737020009 AIPR protein; Region: AIPR; pfam10592 63737020010 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 63737020011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737020012 ATP binding site [chemical binding]; other site 63737020013 putative Mg++ binding site [ion binding]; other site 63737020014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737020015 nucleotide binding region [chemical binding]; other site 63737020016 ATP-binding site [chemical binding]; other site 63737020017 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 63737020018 four helix bundle protein; Region: TIGR02436 63737020019 Uncharacterized conserved protein [Function unknown]; Region: COG5464 63737020020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 63737020021 Transposase; Region: DDE_Tnp_ISL3; pfam01610 63737020022 CHAT domain; Region: CHAT; cl17868 63737020023 AAA ATPase domain; Region: AAA_16; pfam13191 63737020024 GUN4-like; Region: GUN4; pfam05419 63737020025 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737020026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737020027 DNA binding residues [nucleotide binding] 63737020028 dimerization interface [polypeptide binding]; other site 63737020029 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 63737020030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737020031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 63737020032 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 63737020033 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 63737020034 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737020035 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737020036 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737020037 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 63737020038 ligand binding site [chemical binding]; other site 63737020039 flexible hinge region; other site 63737020040 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 63737020041 ligand binding site [chemical binding]; other site 63737020042 flexible hinge region; other site 63737020043 PemK-like protein; Region: PemK; pfam02452 63737020044 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 63737020045 putative active site [active] 63737020046 homotetrameric interface [polypeptide binding]; other site 63737020047 metal binding site [ion binding]; metal-binding site 63737020048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 63737020049 Radical SAM superfamily; Region: Radical_SAM; pfam04055 63737020050 FeS/SAM binding site; other site 63737020051 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 63737020052 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737020053 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737020054 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 63737020055 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 63737020056 putative active site [active] 63737020057 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 63737020058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737020059 Walker A/P-loop; other site 63737020060 ATP binding site [chemical binding]; other site 63737020061 Q-loop/lid; other site 63737020062 ABC transporter signature motif; other site 63737020063 Walker B; other site 63737020064 D-loop; other site 63737020065 H-loop/switch region; other site 63737020066 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 63737020067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 63737020068 Walker A/P-loop; other site 63737020069 ATP binding site [chemical binding]; other site 63737020070 Q-loop/lid; other site 63737020071 ABC transporter signature motif; other site 63737020072 Walker B; other site 63737020073 D-loop; other site 63737020074 H-loop/switch region; other site 63737020075 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 63737020076 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 63737020077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737020078 Walker A motif; other site 63737020079 ATP binding site [chemical binding]; other site 63737020080 Walker B motif; other site 63737020081 arginine finger; other site 63737020082 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 63737020083 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 63737020084 hypothetical protein; Reviewed; Region: PRK12275 63737020085 four helix bundle protein; Region: TIGR02436 63737020086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 63737020087 non-specific DNA binding site [nucleotide binding]; other site 63737020088 salt bridge; other site 63737020089 sequence-specific DNA binding site [nucleotide binding]; other site 63737020090 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 63737020091 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 63737020092 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 63737020093 Catalytic site; other site 63737020094 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 63737020095 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 63737020096 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 63737020097 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 63737020098 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737020099 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737020100 active site 63737020101 catalytic residues [active] 63737020102 DNA binding site [nucleotide binding] 63737020103 Int/Topo IB signature motif; other site 63737020104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737020105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737020106 salt bridge; other site 63737020107 non-specific DNA binding site [nucleotide binding]; other site 63737020108 sequence-specific DNA binding site [nucleotide binding]; other site 63737020109 Double zinc ribbon; Region: DZR; pfam12773 63737020110 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 63737020111 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 63737020112 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 63737020113 IHF dimer interface [polypeptide binding]; other site 63737020114 IHF - DNA interface [nucleotide binding]; other site 63737020115 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 63737020116 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 63737020117 potential catalytic triad [active] 63737020118 conserved cys residue [active] 63737020119 DEAD-like helicases superfamily; Region: DEXDc; smart00487 63737020120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737020121 ATP binding site [chemical binding]; other site 63737020122 putative Mg++ binding site [ion binding]; other site 63737020123 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 63737020124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737020125 nucleotide binding region [chemical binding]; other site 63737020126 ATP-binding site [chemical binding]; other site 63737020127 Methyltransferase domain; Region: Methyltransf_26; pfam13659 63737020128 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 63737020129 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 63737020130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 63737020131 ATP binding site [chemical binding]; other site 63737020132 putative Mg++ binding site [ion binding]; other site 63737020133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 63737020134 ATP-binding site [chemical binding]; other site 63737020135 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 63737020136 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cd01037 63737020137 putative active site [active] 63737020138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 63737020139 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 63737020140 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 63737020141 putative active site [active] 63737020142 putative metal binding site [ion binding]; other site 63737020143 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 63737020144 active site 63737020145 metal binding site [ion binding]; metal-binding site 63737020146 MoxR-like ATPases [General function prediction only]; Region: COG0714 63737020147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737020148 Walker A motif; other site 63737020149 ATP binding site [chemical binding]; other site 63737020150 Walker B motif; other site 63737020151 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 63737020152 AAA domain; Region: AAA_17; pfam13207 63737020153 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 63737020154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 63737020155 Coenzyme A binding pocket [chemical binding]; other site 63737020156 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970 63737020157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737020158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737020159 non-specific DNA binding site [nucleotide binding]; other site 63737020160 salt bridge; other site 63737020161 sequence-specific DNA binding site [nucleotide binding]; other site 63737020162 Protein of unknown function (DUF1392); Region: DUF1392; pfam07154 63737020163 KilA-N domain; Region: KilA-N; pfam04383 63737020164 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 63737020165 Meiotically up-regulated gene 113; Region: MUG113; pfam13455 63737020166 replicative DNA helicase; Region: DnaB; TIGR00665 63737020167 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 63737020168 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 63737020169 Walker A motif; other site 63737020170 ATP binding site [chemical binding]; other site 63737020171 Walker B motif; other site 63737020172 DNA binding loops [nucleotide binding] 63737020173 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 63737020174 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737020175 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 63737020176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 63737020177 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 63737020178 Response regulator receiver domain; Region: Response_reg; pfam00072 63737020179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737020180 active site 63737020181 phosphorylation site [posttranslational modification] 63737020182 intermolecular recognition site; other site 63737020183 dimerization interface [polypeptide binding]; other site 63737020184 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 63737020185 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 63737020186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 63737020187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 63737020188 putative substrate translocation pore; other site 63737020189 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 63737020190 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020191 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020192 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020193 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020194 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 63737020195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737020196 active site 63737020197 phosphorylation site [posttranslational modification] 63737020198 intermolecular recognition site; other site 63737020199 dimerization interface [polypeptide binding]; other site 63737020200 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 63737020201 DNA binding site [nucleotide binding] 63737020202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737020203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737020204 dimer interface [polypeptide binding]; other site 63737020205 phosphorylation site [posttranslational modification] 63737020206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737020207 ATP binding site [chemical binding]; other site 63737020208 Mg2+ binding site [ion binding]; other site 63737020209 G-X-G motif; other site 63737020210 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 63737020211 Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912 63737020212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 63737020213 Histidine kinase; Region: HisKA_3; pfam07730 63737020214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737020215 ATP binding site [chemical binding]; other site 63737020216 Mg2+ binding site [ion binding]; other site 63737020217 G-X-G motif; other site 63737020218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737020219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737020220 active site 63737020221 phosphorylation site [posttranslational modification] 63737020222 intermolecular recognition site; other site 63737020223 dimerization interface [polypeptide binding]; other site 63737020224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737020225 DNA binding residues [nucleotide binding] 63737020226 dimerization interface [polypeptide binding]; other site 63737020227 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 63737020228 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 63737020229 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 63737020230 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 63737020231 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 63737020232 HlyD family secretion protein; Region: HlyD_3; pfam13437 63737020233 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 63737020234 Protein export membrane protein; Region: SecD_SecF; cl14618 63737020235 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 63737020236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 63737020237 Homeodomain-like domain; Region: HTH_23; pfam13384 63737020238 Winged helix-turn helix; Region: HTH_33; pfam13592 63737020239 DDE superfamily endonuclease; Region: DDE_3; pfam13358 63737020240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 63737020241 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 63737020242 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 63737020243 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737020244 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 63737020245 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737020246 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 63737020247 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 63737020248 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 63737020249 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020250 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020251 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 63737020252 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 63737020253 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 63737020254 active site 63737020255 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 63737020256 hydrophobic ligand binding site; other site 63737020257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 63737020258 dimerization interface [polypeptide binding]; other site 63737020259 putative DNA binding site [nucleotide binding]; other site 63737020260 putative Zn2+ binding site [ion binding]; other site 63737020261 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 63737020262 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737020263 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 63737020264 active site 63737020265 DNA binding site [nucleotide binding] 63737020266 Int/Topo IB signature motif; other site 63737020267 mercuric reductase; Validated; Region: PRK06370 63737020268 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 63737020269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 63737020270 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 63737020271 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 63737020272 haemagglutination activity domain; Region: Haemagg_act; pfam05860 63737020273 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 63737020274 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 63737020275 Surface antigen; Region: Bac_surface_Ag; pfam01103 63737020276 CHAT domain; Region: CHAT; cl17868 63737020277 Catalytic domain of Protein Kinases; Region: PKc; cd00180 63737020278 active site 63737020279 ATP binding site [chemical binding]; other site 63737020280 substrate binding site [chemical binding]; other site 63737020281 activation loop (A-loop); other site 63737020282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737020283 binding surface 63737020284 TPR motif; other site 63737020285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737020286 binding surface 63737020287 TPR motif; other site 63737020288 AAA ATPase domain; Region: AAA_16; pfam13191 63737020289 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 63737020290 active site 63737020291 metal binding site [ion binding]; metal-binding site 63737020292 interdomain interaction site; other site 63737020293 AAA domain; Region: AAA_22; pfam13401 63737020294 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737020295 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 63737020296 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737020297 active site 63737020298 catalytic residues [active] 63737020299 DNA binding site [nucleotide binding] 63737020300 Int/Topo IB signature motif; other site 63737020301 Homeodomain-like domain; Region: HTH_23; pfam13384 63737020302 Winged helix-turn helix; Region: HTH_29; pfam13551 63737020303 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 63737020304 AAA domain; Region: AAA_30; pfam13604 63737020305 Family description; Region: UvrD_C_2; pfam13538 63737020306 AAA-like domain; Region: AAA_10; pfam12846 63737020307 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 63737020308 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 63737020309 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 63737020310 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 63737020311 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 63737020312 four helix bundle protein; Region: TIGR02436 63737020313 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 63737020314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737020315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737020316 ATP binding site [chemical binding]; other site 63737020317 Mg2+ binding site [ion binding]; other site 63737020318 G-X-G motif; other site 63737020319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 63737020320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737020321 active site 63737020322 phosphorylation site [posttranslational modification] 63737020323 intermolecular recognition site; other site 63737020324 dimerization interface [polypeptide binding]; other site 63737020325 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 63737020326 DNA binding residues [nucleotide binding] 63737020327 dimerization interface [polypeptide binding]; other site 63737020328 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737020329 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 63737020330 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 63737020331 DDE superfamily endonuclease; Region: DDE_4; pfam13359 63737020332 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 63737020333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 63737020334 Walker A motif; other site 63737020335 ATP binding site [chemical binding]; other site 63737020336 Walker B motif; other site 63737020337 arginine finger; other site 63737020338 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 63737020339 basic region leucin zipper; Region: BRLZ; smart00338 63737020340 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 63737020341 TPR repeat; Region: TPR_11; pfam13414 63737020342 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737020343 binding surface 63737020344 TPR motif; other site 63737020345 TPR repeat; Region: TPR_11; pfam13414 63737020346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737020347 binding surface 63737020348 TPR motif; other site 63737020349 TPR repeat; Region: TPR_11; pfam13414 63737020350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 63737020351 TPR repeat; Region: TPR_11; pfam13414 63737020352 binding surface 63737020353 TPR motif; other site 63737020354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737020355 S-adenosylmethionine binding site [chemical binding]; other site 63737020356 P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872 63737020357 Helicase_C-like; Region: Helicase_C_4; pfam13871 63737020358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 63737020359 S-adenosylmethionine binding site [chemical binding]; other site 63737020360 NIMA-related protein kinase; Provisional; Region: PTZ00266 63737020361 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 63737020362 YcxB-like protein; Region: YcxB; pfam14317 63737020363 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 63737020364 CheB methylesterase; Region: CheB_methylest; pfam01339 63737020365 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 63737020366 AAA ATPase domain; Region: AAA_16; pfam13191 63737020367 NACHT domain; Region: NACHT; pfam05729 63737020368 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737020369 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737020370 structural tetrad; other site 63737020371 FOG: WD40 repeat [General function prediction only]; Region: COG2319 63737020372 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 63737020373 structural tetrad; other site 63737020374 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 63737020375 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 63737020376 Magnesium ion binding site [ion binding]; other site 63737020377 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 63737020378 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 63737020379 active site 63737020380 DNA binding site [nucleotide binding] 63737020381 Int/Topo IB signature motif; other site 63737020382 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 63737020383 histidine biosynthesis bifunctional protein hisIE; Region: PLN02346 63737020384 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 63737020385 putative protofilament interface [polypeptide binding]; other site 63737020386 nucleotide binding site [chemical binding]; other site 63737020387 D5 N terminal like; Region: D5_N; pfam08706 63737020388 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 63737020389 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 63737020390 structural tetrad; other site 63737020391 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 63737020392 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 63737020393 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 63737020394 Int/Topo IB signature motif; other site 63737020395 Predicted transcriptional regulators [Transcription]; Region: COG1725 63737020396 HNH endonuclease; Region: HNH_5; pfam14279 63737020397 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 63737020398 putative hydrophobic ligand binding site [chemical binding]; other site 63737020399 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 63737020400 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 63737020401 NAD binding site [chemical binding]; other site 63737020402 catalytic Zn binding site [ion binding]; other site 63737020403 structural Zn binding site [ion binding]; other site 63737020404 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737020405 GAF domain; Region: GAF; pfam01590 63737020406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737020407 GAF domain; Region: GAF_3; pfam13492 63737020408 PAS fold; Region: PAS_4; pfam08448 63737020409 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 63737020410 PAS fold; Region: PAS_3; pfam08447 63737020411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737020412 putative active site [active] 63737020413 heme pocket [chemical binding]; other site 63737020414 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 63737020415 GAF domain; Region: GAF; pfam01590 63737020416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 63737020417 PAS fold; Region: PAS_3; pfam08447 63737020418 putative active site [active] 63737020419 heme pocket [chemical binding]; other site 63737020420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 63737020421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 63737020422 dimer interface [polypeptide binding]; other site 63737020423 phosphorylation site [posttranslational modification] 63737020424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 63737020425 ATP binding site [chemical binding]; other site 63737020426 Mg2+ binding site [ion binding]; other site 63737020427 G-X-G motif; other site 63737020428 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 63737020429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 63737020430 active site 63737020431 phosphorylation site [posttranslational modification] 63737020432 intermolecular recognition site; other site 63737020433 dimerization interface [polypeptide binding]; other site 63737020434 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 63737020435 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 63737020436 Transposase domain (DUF772); Region: DUF772; pfam05598 63737020437 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 63737020438 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 63737020439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 63737020440 salt bridge; other site 63737020441 non-specific DNA binding site [nucleotide binding]; other site 63737020442 sequence-specific DNA binding site [nucleotide binding]; other site 63737020443 Double zinc ribbon; Region: DZR; pfam12773 63737020444 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 63737020445 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 63737020446 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 63737020447 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 63737020448 active site 63737020449 catalytic residues [active] 63737020450 DNA binding site [nucleotide binding] 63737020451 Int/Topo IB signature motif; other site 63737020452 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 63737020453 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526