-- dump date   	20140619_165059
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
196162000001	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
196162000002	DnaA box-binding interface [nucleotide binding]; other site
196162000003	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162000004	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
196162000005	Walker A/P-loop; other site
196162000006	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
196162000007	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162000008	putative catalytic site [active]
196162000009	putative metal binding site [ion binding]; other site
196162000010	putative phosphate binding site [ion binding]; other site
196162000011	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162000012	putative catalytic site [active]
196162000013	putative metal binding site [ion binding]; other site
196162000014	putative phosphate binding site [ion binding]; other site
196162000015	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
196162000016	N-acetyl-D-glucosamine binding site [chemical binding]; other site
196162000017	catalytic residue [active]
196162000018	AAA-like domain; Region: AAA_10; pfam12846
196162000019	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162000020	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162000021	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
196162000022	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
196162000023	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162000024	active site
196162000025	DNA binding site [nucleotide binding]
196162000026	Int/Topo IB signature motif; other site
196162000027	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
196162000028	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162000029	active site
196162000030	catalytic residues [active]
196162000031	DNA binding site [nucleotide binding]
196162000032	Int/Topo IB signature motif; other site
196162000033	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196162000034	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
196162000035	ATP binding site [chemical binding]; other site
196162000036	Walker A motif; other site
196162000037	hexamer interface [polypeptide binding]; other site
196162000038	Walker B motif; other site
196162000039	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
196162000040	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162000041	dimerization interface [polypeptide binding]; other site
196162000042	putative DNA binding site [nucleotide binding]; other site
196162000043	putative Zn2+ binding site [ion binding]; other site
196162000044	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
196162000045	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
196162000046	AAA domain; Region: AAA_31; pfam13614
196162000047	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162000048	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162000049	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162000050	Magnesium ion binding site [ion binding]; other site
196162000051	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
196162000052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162000053	S-adenosylmethionine binding site [chemical binding]; other site
196162000054	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
196162000055	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
196162000056	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
196162000057	helicase superfamily c-terminal domain; Region: HELICc; smart00490
196162000058	Protein of unknown function (DUF1173); Region: DUF1173; pfam06666
196162000059	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
196162000060	AAA ATPase domain; Region: AAA_15; pfam13175
196162000061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162000062	Walker A/P-loop; other site
196162000063	ATP binding site [chemical binding]; other site
196162000064	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
196162000065	putative active site [active]
196162000066	putative metal-binding site [ion binding]; other site
196162000067	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
196162000068	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
196162000069	McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117
196162000070	Mrr N-terminal domain; Region: Mrr_N; pfam14338
196162000071	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162000072	Walker A motif; other site
196162000073	ATP binding site [chemical binding]; other site
196162000074	Walker B motif; other site
196162000075	arginine finger; other site
196162000076	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196162000077	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162000078	ATP binding site [chemical binding]; other site
196162000079	putative Mg++ binding site [ion binding]; other site
196162000080	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162000081	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
196162000082	nucleotide binding region [chemical binding]; other site
196162000083	ATP-binding site [chemical binding]; other site
196162000084	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
196162000085	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162000086	ATP binding site [chemical binding]; other site
196162000087	putative Mg++ binding site [ion binding]; other site
196162000088	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162000089	ATP-binding site [chemical binding]; other site
196162000090	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
196162000091	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
196162000092	putative active site [active]
196162000093	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
196162000094	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
196162000095	cofactor binding site; other site
196162000096	DNA binding site [nucleotide binding]
196162000097	substrate interaction site [chemical binding]; other site
196162000098	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
196162000099	ATP-binding site [chemical binding]; other site
196162000100	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
196162000101	YfbU domain; Region: YfbU; cl01137
196162000102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162000103	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
196162000104	nucleotide binding region [chemical binding]; other site
196162000105	ATP-binding site [chemical binding]; other site
196162000106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162000107	ATP binding site [chemical binding]; other site
196162000108	putative Mg++ binding site [ion binding]; other site
196162000109	DNA protecting protein DprA; Region: dprA; TIGR00732
196162000110	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
196162000111	DNA protecting protein DprA; Region: dprA; TIGR00732
196162000112	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
196162000113	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196162000114	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
196162000115	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162000116	active site
196162000117	catalytic residues [active]
196162000118	DNA binding site [nucleotide binding]
196162000119	Int/Topo IB signature motif; other site
196162000120	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162000121	DNA binding site [nucleotide binding]
196162000122	Int/Topo IB signature motif; other site
196162000123	active site
196162000124	catalytic residues [active]
196162000125	ParB-like nuclease domain; Region: ParBc; pfam02195
196162000126	TrwC relaxase; Region: TrwC; pfam08751
196162000127	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
196162000128	AAA domain; Region: AAA_30; pfam13604
196162000129	Family description; Region: UvrD_C_2; pfam13538
196162000130	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
196162000131	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
196162000132	active site
196162000133	metal binding site [ion binding]; metal-binding site
196162000134	interdomain interaction site; other site
196162000135	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
196162000136	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
196162000137	molybdopterin cofactor binding site [chemical binding]; other site
196162000138	substrate binding site [chemical binding]; other site
196162000139	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
196162000140	molybdopterin cofactor binding site; other site
196162000141	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
196162000142	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162000143	catalytic loop [active]
196162000144	iron binding site [ion binding]; other site
196162000145	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. These flavoprotein monooxygenases use molecular oxygen as a substrate and require reduced FAD. One atom of oxygen is...; Region: monooxygenase_like; cd06212
196162000146	FAD binding pocket [chemical binding]; other site
196162000147	FAD binding motif [chemical binding]; other site
196162000148	phosphate binding motif [ion binding]; other site
196162000149	beta-alpha-beta structure motif; other site
196162000150	NAD binding pocket [chemical binding]; other site
196162000151	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
196162000152	dimerization interface [polypeptide binding]; other site
196162000153	putative path to active site cavity [active]
196162000154	diiron center [ion binding]; other site
196162000155	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
196162000156	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
196162000157	dimerization interface [polypeptide binding]; other site
196162000158	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
196162000159	substrate binding site [chemical binding]; other site
196162000160	THF binding site; other site
196162000161	zinc-binding site [ion binding]; other site
196162000162	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
196162000163	CoA binding domain; Region: CoA_binding_2; pfam13380
196162000164	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
196162000165	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
196162000166	Coenzyme A transferase; Region: CoA_trans; cl17247
196162000167	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
196162000168	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
196162000169	classical (c) SDRs; Region: SDR_c; cd05233
196162000170	NAD(P) binding site [chemical binding]; other site
196162000171	active site
196162000172	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
196162000173	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162000174	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162000175	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
196162000176	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
196162000177	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
196162000178	tetramer interface [polypeptide binding]; other site
196162000179	active site
196162000180	D-cysteine desulfhydrase; Validated; Region: PRK03910
196162000181	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
196162000182	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162000183	catalytic residue [active]
196162000184	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
196162000185	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
196162000186	active sites [active]
196162000187	tetramer interface [polypeptide binding]; other site
196162000188	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
196162000189	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196162000190	Active Sites [active]
196162000191	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
196162000192	putative catalytic cysteine [active]
196162000193	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
196162000194	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162000195	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
196162000196	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
196162000197	classical (c) SDRs; Region: SDR_c; cd05233
196162000198	NAD(P) binding site [chemical binding]; other site
196162000199	active site
196162000200	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
196162000201	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162000202	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162000203	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162000204	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
196162000205	HTH-like domain; Region: HTH_21; pfam13276
196162000206	Integrase core domain; Region: rve; pfam00665
196162000207	Integrase core domain; Region: rve_3; pfam13683
196162000208	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
196162000209	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162000210	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
196162000211	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162000212	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
196162000213	putative catalytic cysteine [active]
196162000214	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
196162000215	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196162000216	Active Sites [active]
196162000217	Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165
196162000218	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
196162000219	tetramer interface [polypeptide binding]; other site
196162000220	D-cysteine desulfhydrase; Validated; Region: PRK03910
196162000221	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
196162000222	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162000223	catalytic residue [active]
196162000224	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
196162000225	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
196162000226	tetramer interface [polypeptide binding]; other site
196162000227	active site
196162000228	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
196162000229	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
196162000230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162000231	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162000232	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162000233	classical (c) SDRs; Region: SDR_c; cd05233
196162000234	NAD(P) binding site [chemical binding]; other site
196162000235	active site
196162000236	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
196162000237	Coenzyme A transferase; Region: CoA_trans; cl17247
196162000238	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
196162000239	CoA binding domain; Region: CoA_binding_2; pfam13380
196162000240	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
196162000241	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
196162000242	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
196162000243	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
196162000244	active site
196162000245	nucleophile elbow; other site
196162000246	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
196162000247	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162000248	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162000249	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
196162000250	active site
196162000251	putative DNA binding site [nucleotide binding]; other site
196162000252	Helix-turn-helix domain; Region: HTH_20; pfam12840
196162000253	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162000254	putative Zn2+ binding site [ion binding]; other site
196162000255	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162000256	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
196162000257	Cupin domain; Region: Cupin_2; cl17218
196162000258	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
196162000259	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
196162000260	dimer interface [polypeptide binding]; other site
196162000261	TPP-binding site [chemical binding]; other site
196162000262	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162000263	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162000264	putative DNA binding site [nucleotide binding]; other site
196162000265	putative Zn2+ binding site [ion binding]; other site
196162000266	Ferredoxin [Energy production and conversion]; Region: COG1146
196162000267	4Fe-4S binding domain; Region: Fer4; pfam00037
196162000268	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
196162000269	Cupin domain; Region: Cupin_2; cl17218
196162000270	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
196162000271	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162000272	inhibitor-cofactor binding pocket; inhibition site
196162000273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162000274	catalytic residue [active]
196162000275	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
196162000276	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
196162000277	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
196162000278	D-pathway; other site
196162000279	Putative ubiquinol binding site [chemical binding]; other site
196162000280	Low-spin heme (heme b) binding site [chemical binding]; other site
196162000281	Putative water exit pathway; other site
196162000282	Binuclear center (heme o3/CuB) [ion binding]; other site
196162000283	K-pathway; other site
196162000284	Putative proton exit pathway; other site
196162000285	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
196162000286	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162000287	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
196162000288	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
196162000289	Protein of unknown function, DUF488; Region: DUF488; cl01246
196162000290	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
196162000291	putative active site [active]
196162000292	transaldolase; Provisional; Region: PRK03903
196162000293	catalytic residue [active]
196162000294	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162000295	Ligand Binding Site [chemical binding]; other site
196162000296	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162000297	Ligand Binding Site [chemical binding]; other site
196162000298	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
196162000299	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
196162000300	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
196162000301	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
196162000302	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196162000303	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
196162000304	MarR family; Region: MarR_2; pfam12802
196162000305	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
196162000306	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
196162000307	PLD-like domain; Region: PLDc_2; pfam13091
196162000308	putative active site [active]
196162000309	putative catalytic site [active]
196162000310	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
196162000311	RibD C-terminal domain; Region: RibD_C; cl17279
196162000312	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
196162000313	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
196162000314	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
196162000315	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
196162000316	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
196162000317	Bacterial transcriptional activator domain; Region: BTAD; smart01043
196162000318	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196162000319	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162000320	S-adenosylmethionine binding site [chemical binding]; other site
196162000321	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162000322	Histidine kinase; Region: HisKA_3; pfam07730
196162000323	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162000324	ATP binding site [chemical binding]; other site
196162000325	Mg2+ binding site [ion binding]; other site
196162000326	G-X-G motif; other site
196162000327	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162000329	active site
196162000330	phosphorylation site [posttranslational modification]
196162000331	intermolecular recognition site; other site
196162000332	dimerization interface [polypeptide binding]; other site
196162000333	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000334	DNA binding residues [nucleotide binding]
196162000335	dimerization interface [polypeptide binding]; other site
196162000336	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000337	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162000338	active site
196162000339	phosphorylation site [posttranslational modification]
196162000340	intermolecular recognition site; other site
196162000341	dimerization interface [polypeptide binding]; other site
196162000342	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000343	DNA binding residues [nucleotide binding]
196162000344	dimerization interface [polypeptide binding]; other site
196162000345	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162000346	Histidine kinase; Region: HisKA_3; pfam07730
196162000347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162000348	ATP binding site [chemical binding]; other site
196162000349	Mg2+ binding site [ion binding]; other site
196162000350	G-X-G motif; other site
196162000351	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
196162000352	Histidine kinase; Region: HisKA_3; pfam07730
196162000353	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196162000354	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162000356	active site
196162000357	phosphorylation site [posttranslational modification]
196162000358	intermolecular recognition site; other site
196162000359	dimerization interface [polypeptide binding]; other site
196162000360	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000361	DNA binding residues [nucleotide binding]
196162000362	dimerization interface [polypeptide binding]; other site
196162000363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162000364	Histidine kinase; Region: HisKA_3; pfam07730
196162000365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162000366	ATP binding site [chemical binding]; other site
196162000367	Mg2+ binding site [ion binding]; other site
196162000368	G-X-G motif; other site
196162000369	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
196162000371	active site
196162000372	phosphorylation site [posttranslational modification]
196162000373	intermolecular recognition site; other site
196162000374	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000375	DNA binding residues [nucleotide binding]
196162000376	dimerization interface [polypeptide binding]; other site
196162000377	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
196162000378	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
196162000379	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162000380	FAD binding domain; Region: FAD_binding_4; pfam01565
196162000381	Berberine and berberine like; Region: BBE; pfam08031
196162000382	Predicted transcriptional regulators [Transcription]; Region: COG1733
196162000383	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162000384	putative DNA binding site [nucleotide binding]; other site
196162000385	putative Zn2+ binding site [ion binding]; other site
196162000386	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000387	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000388	DNA binding residues [nucleotide binding]
196162000389	dimerization interface [polypeptide binding]; other site
196162000390	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
196162000391	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162000392	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
196162000393	catalytic site [active]
196162000394	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162000395	HD domain; Region: HD_5; pfam13487
196162000396	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196162000397	Zn2+ binding site [ion binding]; other site
196162000398	Mg2+ binding site [ion binding]; other site
196162000399	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000400	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000401	DNA binding residues [nucleotide binding]
196162000402	dimerization interface [polypeptide binding]; other site
196162000403	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162000404	S-adenosylmethionine binding site [chemical binding]; other site
196162000405	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000406	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000407	DNA binding residues [nucleotide binding]
196162000408	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
196162000409	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162000410	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162000411	DNA binding residues [nucleotide binding]
196162000412	dimerization interface [polypeptide binding]; other site
196162000413	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
196162000414	hydrophobic ligand binding site; other site
196162000415	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
196162000416	AAA ATPase domain; Region: AAA_16; pfam13191
196162000417	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162000418	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196162000419	NAD(P) binding site [chemical binding]; other site
196162000420	active site
196162000421	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
196162000422	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
196162000423	RibD C-terminal domain; Region: RibD_C; cl17279
196162000424	Staphylococcal nuclease homologues; Region: SNc; smart00318
196162000425	TrwC relaxase; Region: TrwC; pfam08751
196162000426	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
196162000427	AAA domain; Region: AAA_30; pfam13604
196162000428	Family description; Region: UvrD_C_2; pfam13538
196162000429	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
196162000430	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
196162000431	active site
196162000432	metal binding site [ion binding]; metal-binding site
196162000433	interdomain interaction site; other site
196162000434	tetracycline repressor protein TetR; Provisional; Region: PRK13756
196162000435	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162000436	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
196162000437	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162000438	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
196162000439	Walker A/P-loop; other site
196162000440	ATP binding site [chemical binding]; other site
196162000441	Q-loop/lid; other site
196162000442	ABC transporter signature motif; other site
196162000443	Walker B; other site
196162000444	D-loop; other site
196162000445	H-loop/switch region; other site
196162000446	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
196162000447	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196162000448	Alkylmercury lyase; Region: MerB; pfam03243
196162000449	Helix-Turn-Helix DNA binding domain of MerR2-like transcription regulators; Region: HTH_MerR2; cd04769
196162000450	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196162000451	DNA binding residues [nucleotide binding]
196162000452	putative dimer interface [polypeptide binding]; other site
196162000453	mercuric reductase; Region: MerA; TIGR02053
196162000454	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162000455	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162000456	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
196162000457	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
196162000458	DNA binding residues [nucleotide binding]
196162000459	dimer interface [polypeptide binding]; other site
196162000460	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
196162000461	Sodium Bile acid symporter family; Region: SBF; cl17470
196162000462	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
196162000463	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
196162000464	DNA binding residues [nucleotide binding]
196162000465	dimer interface [polypeptide binding]; other site
196162000466	mercury binding site [ion binding]; other site
196162000467	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162000468	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162000469	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196162000470	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
196162000471	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
196162000472	DNA binding residues [nucleotide binding]
196162000473	dimer interface [polypeptide binding]; other site
196162000474	mercury binding site [ion binding]; other site
196162000475	hypothetical protein; Provisional; Region: PRK02237
196162000476	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
196162000477	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
196162000478	DNA binding site [nucleotide binding]
196162000479	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
196162000480	AAA ATPase domain; Region: AAA_16; pfam13191
196162000481	Predicted ATPase [General function prediction only]; Region: COG3903
196162000482	Tetratricopeptide repeat; Region: TPR_12; pfam13424
196162000483	Tetratricopeptide repeat; Region: TPR_12; pfam13424
196162000484	Tetratricopeptide repeat; Region: TPR_12; pfam13424
196162000485	MMPL family; Region: MMPL; pfam03176
196162000486	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162000487	non-specific DNA binding site [nucleotide binding]; other site
196162000488	salt bridge; other site
196162000489	sequence-specific DNA binding site [nucleotide binding]; other site
196162000490	Domain of unknown function (DUF955); Region: DUF955; cl01076
196162000491	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
196162000492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162000493	Walker A motif; other site
196162000494	ATP binding site [chemical binding]; other site
196162000495	Walker B motif; other site
196162000496	arginine finger; other site
196162000497	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
196162000498	DnaA box-binding interface [nucleotide binding]; other site
196162000499	DNA polymerase III subunit beta; Validated; Region: PRK07761
196162000500	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
196162000501	putative DNA binding surface [nucleotide binding]; other site
196162000502	dimer interface [polypeptide binding]; other site
196162000503	beta-clamp/clamp loader binding surface; other site
196162000504	beta-clamp/translesion DNA polymerase binding surface; other site
196162000505	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
196162000506	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
196162000507	recombination protein F; Reviewed; Region: recF; PRK00064
196162000508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162000509	Walker A/P-loop; other site
196162000510	ATP binding site [chemical binding]; other site
196162000511	Q-loop/lid; other site
196162000512	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162000513	ABC transporter signature motif; other site
196162000514	Walker B; other site
196162000515	D-loop; other site
196162000516	Protein of unknown function (DUF721); Region: DUF721; cl02324
196162000517	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
196162000518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162000519	Mg2+ binding site [ion binding]; other site
196162000520	G-X-G motif; other site
196162000521	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
196162000522	anchoring element; other site
196162000523	dimer interface [polypeptide binding]; other site
196162000524	ATP binding site [chemical binding]; other site
196162000525	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
196162000526	active site
196162000527	putative metal-binding site [ion binding]; other site
196162000528	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
196162000529	DNA gyrase subunit A; Validated; Region: PRK05560
196162000530	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
196162000531	CAP-like domain; other site
196162000532	active site
196162000533	primary dimer interface [polypeptide binding]; other site
196162000534	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196162000535	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196162000536	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196162000537	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196162000538	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196162000539	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
196162000540	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
196162000541	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
196162000542	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
196162000543	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162000544	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162000545	DNA-binding site [nucleotide binding]; DNA binding site
196162000546	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
196162000547	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
196162000548	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
196162000549	nucleophile elbow; other site
196162000550	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162000551	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
196162000552	putative acyl-acceptor binding pocket; other site
196162000553	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
196162000554	active site
196162000555	B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034
196162000556	Rhomboid family; Region: Rhomboid; pfam01694
196162000557	putative active site [active]
196162000558	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
196162000559	Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781
196162000560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
196162000561	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
196162000562	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
196162000563	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162000564	active site
196162000565	ATP binding site [chemical binding]; other site
196162000566	substrate binding site [chemical binding]; other site
196162000567	activation loop (A-loop); other site
196162000568	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162000569	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162000570	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162000571	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162000572	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162000573	active site
196162000574	ATP binding site [chemical binding]; other site
196162000575	substrate binding site [chemical binding]; other site
196162000576	activation loop (A-loop); other site
196162000577	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
196162000578	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196162000579	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
196162000580	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
196162000581	active site
196162000582	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
196162000583	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
196162000584	phosphopeptide binding site; other site
196162000585	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
196162000586	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
196162000587	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
196162000588	phosphopeptide binding site; other site
196162000589	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
196162000590	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162000591	Coenzyme A binding pocket [chemical binding]; other site
196162000592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162000593	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162000594	putative substrate translocation pore; other site
196162000595	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162000596	active site 2 [active]
196162000597	active site 1 [active]
196162000598	L-aspartate oxidase; Provisional; Region: PRK06175
196162000599	L-aspartate oxidase; Region: nadB; TIGR00551
196162000600	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
196162000601	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196162000602	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
196162000603	inhibitor site; inhibition site
196162000604	active site
196162000605	dimer interface [polypeptide binding]; other site
196162000606	catalytic residue [active]
196162000607	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162000608	Predicted dehydrogenase [General function prediction only]; Region: COG0579
196162000609	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
196162000610	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162000611	DNA-binding site [nucleotide binding]; DNA binding site
196162000612	FCD domain; Region: FCD; pfam07729
196162000613	thiamine pyrophosphate protein; Validated; Region: PRK08199
196162000614	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196162000615	PYR/PP interface [polypeptide binding]; other site
196162000616	dimer interface [polypeptide binding]; other site
196162000617	TPP binding site [chemical binding]; other site
196162000618	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196162000619	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
196162000620	TPP-binding site [chemical binding]; other site
196162000621	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
196162000622	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
196162000623	dimer interface [polypeptide binding]; other site
196162000624	NADP binding site [chemical binding]; other site
196162000625	catalytic residues [active]
196162000626	hypothetical protein; Validated; Region: PRK08245
196162000627	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162000628	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162000629	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
196162000630	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
196162000631	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162000632	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162000633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162000634	dimer interface [polypeptide binding]; other site
196162000635	conserved gate region; other site
196162000636	putative PBP binding loops; other site
196162000637	ABC-ATPase subunit interface; other site
196162000638	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162000639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162000640	dimer interface [polypeptide binding]; other site
196162000641	conserved gate region; other site
196162000642	putative PBP binding loops; other site
196162000643	ABC-ATPase subunit interface; other site
196162000644	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162000645	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
196162000646	substrate binding site [chemical binding]; other site
196162000647	oxyanion hole (OAH) forming residues; other site
196162000648	trimer interface [polypeptide binding]; other site
196162000649	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
196162000650	active site
196162000651	catalytic site [active]
196162000652	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162000653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162000654	active site
196162000655	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162000656	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162000657	Transcriptional regulators [Transcription]; Region: GntR; COG1802
196162000658	FCD domain; Region: FCD; pfam07729
196162000659	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
196162000660	Cna protein B-type domain; Region: Cna_B; pfam05738
196162000661	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
196162000662	short chain dehydrogenase; Provisional; Region: PRK08219
196162000663	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
196162000664	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
196162000665	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
196162000666	substrate binding [chemical binding]; other site
196162000667	active site
196162000668	Protein of unknown function (DUF2961); Region: DUF2961; pfam11175
196162000669	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cl00240
196162000670	hinge region; other site
196162000671	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162000672	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162000673	DNA binding site [nucleotide binding]
196162000674	domain linker motif; other site
196162000675	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196162000676	ligand binding site [chemical binding]; other site
196162000677	dimerization interface [polypeptide binding]; other site
196162000678	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196162000679	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196162000680	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162000681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
196162000682	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162000683	putative PBP binding loops; other site
196162000684	dimer interface [polypeptide binding]; other site
196162000685	ABC-ATPase subunit interface; other site
196162000686	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162000687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162000688	dimer interface [polypeptide binding]; other site
196162000689	conserved gate region; other site
196162000690	putative PBP binding loops; other site
196162000691	ABC-ATPase subunit interface; other site
196162000692	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196162000693	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
196162000694	putative substrate binding site [chemical binding]; other site
196162000695	putative ATP binding site [chemical binding]; other site
196162000696	Transposase; Region: HTH_Tnp_1; cl17663
196162000697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
196162000698	Helix-turn-helix domain; Region: HTH_38; pfam13936
196162000699	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196162000700	Integrase core domain; Region: rve; pfam00665
196162000701	Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048
196162000702	LysE type translocator; Region: LysE; cl00565
196162000703	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162000704	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162000705	putative DNA binding site [nucleotide binding]; other site
196162000706	putative Zn2+ binding site [ion binding]; other site
196162000707	AsnC family; Region: AsnC_trans_reg; pfam01037
196162000708	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
196162000709	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
196162000710	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196162000711	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162000712	non-specific DNA binding site [nucleotide binding]; other site
196162000713	salt bridge; other site
196162000714	sequence-specific DNA binding site [nucleotide binding]; other site
196162000715	Cupin domain; Region: Cupin_2; cl17218
196162000716	SnoaL-like domain; Region: SnoaL_3; pfam13474
196162000717	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
196162000718	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
196162000719	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162000720	ligand binding site [chemical binding]; other site
196162000721	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162000722	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162000723	Walker A/P-loop; other site
196162000724	ATP binding site [chemical binding]; other site
196162000725	Q-loop/lid; other site
196162000726	ABC transporter signature motif; other site
196162000727	Walker B; other site
196162000728	D-loop; other site
196162000729	H-loop/switch region; other site
196162000730	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162000731	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162000732	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162000733	TM-ABC transporter signature motif; other site
196162000734	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162000735	classical (c) SDRs; Region: SDR_c; cd05233
196162000736	NAD(P) binding site [chemical binding]; other site
196162000737	active site
196162000738	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
196162000739	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
196162000740	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
196162000741	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
196162000742	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
196162000743	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
196162000744	dimer interface [polypeptide binding]; other site
196162000745	active site
196162000746	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162000747	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162000748	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
196162000749	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
196162000750	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196162000751	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
196162000752	inhibitor site; inhibition site
196162000753	active site
196162000754	dimer interface [polypeptide binding]; other site
196162000755	catalytic residue [active]
196162000756	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
196162000757	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
196162000758	dimer interface [polypeptide binding]; other site
196162000759	NADP binding site [chemical binding]; other site
196162000760	catalytic residues [active]
196162000761	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162000762	Proline dehydrogenase; Region: Pro_dh; cl03282
196162000763	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162000764	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
196162000765	NAD(P) binding site [chemical binding]; other site
196162000766	catalytic residues [active]
196162000767	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162000768	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
196162000769	hypothetical protein; Provisional; Region: PRK05463
196162000770	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
196162000771	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
196162000772	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
196162000773	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
196162000774	Protein of unknown function (DUF917); Region: DUF917; pfam06032
196162000775	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162000776	Protein of unknown function (DUF917); Region: DUF917; pfam06032
196162000777	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
196162000778	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162000779	ligand binding site [chemical binding]; other site
196162000780	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162000781	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162000782	Walker A/P-loop; other site
196162000783	ATP binding site [chemical binding]; other site
196162000784	Q-loop/lid; other site
196162000785	ABC transporter signature motif; other site
196162000786	Walker B; other site
196162000787	D-loop; other site
196162000788	H-loop/switch region; other site
196162000789	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162000790	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162000791	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162000792	TM-ABC transporter signature motif; other site
196162000793	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
196162000794	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
196162000795	active site
196162000796	dimer interface [polypeptide binding]; other site
196162000797	hypothetical protein; Provisional; Region: PRK08296
196162000798	hypothetical protein; Provisional; Region: PRK08296
196162000799	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
196162000800	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
196162000801	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162000802	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162000803	active site
196162000804	catalytic tetrad [active]
196162000805	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162000806	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162000807	NAD(P) binding site [chemical binding]; other site
196162000808	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
196162000809	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162000810	hydrophobic ligand binding site; other site
196162000811	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
196162000812	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
196162000813	Malic enzyme, N-terminal domain; Region: malic; pfam00390
196162000814	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
196162000815	putative NAD(P) binding site [chemical binding]; other site
196162000816	Transport protein; Region: actII; TIGR00833
196162000817	Transport protein; Region: actII; TIGR00833
196162000818	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162000819	MarR family; Region: MarR; pfam01047
196162000820	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162000821	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196162000822	nucleotide binding site [chemical binding]; other site
196162000823	Predicted transcriptional regulators [Transcription]; Region: COG1695
196162000824	Uncharacterized conserved protein [Function unknown]; Region: COG1432
196162000825	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
196162000826	putative metal binding site [ion binding]; other site
196162000827	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
196162000828	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
196162000829	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162000830	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162000831	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
196162000832	Walker A/P-loop; other site
196162000833	ATP binding site [chemical binding]; other site
196162000834	Q-loop/lid; other site
196162000835	ABC transporter signature motif; other site
196162000836	Walker B; other site
196162000837	D-loop; other site
196162000838	H-loop/switch region; other site
196162000839	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196162000840	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
196162000841	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
196162000842	Fatty acid desaturase; Region: FA_desaturase; pfam00487
196162000843	Di-iron ligands [ion binding]; other site
196162000844	Rubredoxin [Energy production and conversion]; Region: COG1773
196162000845	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
196162000846	iron binding site [ion binding]; other site
196162000847	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162000848	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162000849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162000850	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196162000851	putative substrate translocation pore; other site
196162000852	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
196162000853	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
196162000854	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
196162000855	putative active site [active]
196162000856	putative substrate binding site [chemical binding]; other site
196162000857	putative cosubstrate binding site; other site
196162000858	catalytic site [active]
196162000859	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
196162000860	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196162000861	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
196162000862	NAD(P) binding site [chemical binding]; other site
196162000863	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
196162000864	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
196162000865	active site
196162000866	Zn binding site [ion binding]; other site
196162000867	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
196162000868	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162000869	ATP binding site [chemical binding]; other site
196162000870	putative Mg++ binding site [ion binding]; other site
196162000871	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162000872	nucleotide binding region [chemical binding]; other site
196162000873	ATP-binding site [chemical binding]; other site
196162000874	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162000875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162000876	putative substrate translocation pore; other site
196162000877	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162000878	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
196162000879	catalytic residues [active]
196162000880	dimer interface [polypeptide binding]; other site
196162000881	SNF2 Helicase protein; Region: DUF3670; pfam12419
196162000882	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
196162000883	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162000884	ATP binding site [chemical binding]; other site
196162000885	putative Mg++ binding site [ion binding]; other site
196162000886	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
196162000887	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162000888	nucleotide binding region [chemical binding]; other site
196162000889	ATP-binding site [chemical binding]; other site
196162000890	Uncharacterized conserved protein [Function unknown]; Region: COG4279
196162000891	SWIM zinc finger; Region: SWIM; pfam04434
196162000892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162000893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162000894	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
196162000895	putative homodimer interface [polypeptide binding]; other site
196162000896	putative homotetramer interface [polypeptide binding]; other site
196162000897	putative allosteric switch controlling residues; other site
196162000898	putative metal binding site [ion binding]; other site
196162000899	putative homodimer-homodimer interface [polypeptide binding]; other site
196162000900	Domain of unknown function DUF302; Region: DUF302; cl01364
196162000901	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
196162000902	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162000903	catalytic residues [active]
196162000904	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
196162000905	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
196162000906	metal ion-dependent adhesion site (MIDAS); other site
196162000907	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
196162000908	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196162000909	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
196162000910	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196162000911	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162000912	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
196162000913	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162000914	carboxyltransferase (CT) interaction site; other site
196162000915	biotinylation site [posttranslational modification]; other site
196162000916	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
196162000917	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
196162000918	active site
196162000919	catalytic residues [active]
196162000920	metal binding site [ion binding]; metal-binding site
196162000921	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
196162000922	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196162000923	active site residue [active]
196162000924	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
196162000925	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
196162000926	putative DNA binding site [nucleotide binding]; other site
196162000927	catalytic residue [active]
196162000928	putative H2TH interface [polypeptide binding]; other site
196162000929	putative catalytic residues [active]
196162000930	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196162000931	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
196162000932	AAA ATPase domain; Region: AAA_16; pfam13191
196162000933	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162000934	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162000935	active site
196162000936	metal binding site [ion binding]; metal-binding site
196162000937	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
196162000938	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
196162000939	active site
196162000940	catalytic site [active]
196162000941	SEC-C motif; Region: SEC-C; pfam02810
196162000942	cyclase homology domain; Region: CHD; cd07302
196162000943	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
196162000944	nucleotidyl binding site; other site
196162000945	metal binding site [ion binding]; metal-binding site
196162000946	dimer interface [polypeptide binding]; other site
196162000947	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196162000948	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196162000949	ligand binding site [chemical binding]; other site
196162000950	flexible hinge region; other site
196162000951	arginine deiminase; Provisional; Region: PRK01388
196162000952	Predicted membrane protein [Function unknown]; Region: COG2119
196162000953	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
196162000954	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
196162000955	hypothetical protein; Provisional; Region: PRK04194
196162000956	AIR carboxylase; Region: AIRC; smart01001
196162000957	prephenate dehydratase; Provisional; Region: PRK11899
196162000958	Prephenate dehydratase; Region: PDT; pfam00800
196162000959	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
196162000960	putative L-Phe binding site [chemical binding]; other site
196162000961	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
196162000962	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
196162000963	active site
196162000964	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
196162000965	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
196162000966	seryl-tRNA synthetase; Provisional; Region: PRK05431
196162000967	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
196162000968	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
196162000969	dimer interface [polypeptide binding]; other site
196162000970	active site
196162000971	motif 1; other site
196162000972	motif 2; other site
196162000973	motif 3; other site
196162000974	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
196162000975	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162000976	active site
196162000977	motif I; other site
196162000978	motif II; other site
196162000979	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162000980	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196162000981	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162000982	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
196162000983	active site
196162000984	motif I; other site
196162000985	motif II; other site
196162000986	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
196162000987	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196162000988	NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by...; Region: NTR_TIMP_like; cd03577
196162000989	Metzincin-binding interface; other site
196162000990	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
196162000991	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
196162000992	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
196162000993	NAD(P) binding site [chemical binding]; other site
196162000994	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
196162000995	active site
196162000996	Predicted amidohydrolase [General function prediction only]; Region: COG0388
196162000997	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
196162000998	putative active site [active]
196162000999	catalytic triad [active]
196162001000	putative dimer interface [polypeptide binding]; other site
196162001001	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162001002	carboxyltransferase (CT) interaction site; other site
196162001003	biotinylation site [posttranslational modification]; other site
196162001004	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162001005	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162001006	DNA binding residues [nucleotide binding]
196162001007	dimerization interface [polypeptide binding]; other site
196162001008	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162001009	PLD-like domain; Region: PLDc_2; pfam13091
196162001010	putative active site [active]
196162001011	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
196162001012	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
196162001013	active site
196162001014	substrate-binding site [chemical binding]; other site
196162001015	metal-binding site [ion binding]
196162001016	GTP binding site [chemical binding]; other site
196162001017	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162001018	dimer interface [polypeptide binding]; other site
196162001019	phosphorylation site [posttranslational modification]
196162001020	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
196162001021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162001022	ATP binding site [chemical binding]; other site
196162001023	Mg2+ binding site [ion binding]; other site
196162001024	G-X-G motif; other site
196162001025	PBP superfamily domain; Region: PBP_like_2; cl17296
196162001026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162001027	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162001028	dimer interface [polypeptide binding]; other site
196162001029	phosphorylation site [posttranslational modification]
196162001030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162001031	ATP binding site [chemical binding]; other site
196162001032	Mg2+ binding site [ion binding]; other site
196162001033	G-X-G motif; other site
196162001034	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162001035	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162001036	DNA binding site [nucleotide binding]
196162001037	domain linker motif; other site
196162001038	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279
196162001039	putative dimerization interface [polypeptide binding]; other site
196162001040	putative ligand binding site [chemical binding]; other site
196162001041	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
196162001042	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
196162001043	active site
196162001044	catalytic site [active]
196162001045	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
196162001046	FAD binding domain; Region: FAD_binding_2; pfam00890
196162001047	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
196162001048	tricarballylate dehydrogenase; Validated; Region: PRK08274
196162001049	Predicted oxidoreductase [General function prediction only]; Region: COG3573
196162001050	Isochorismatase family; Region: Isochorismatase; pfam00857
196162001051	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
196162001052	catalytic triad [active]
196162001053	conserved cis-peptide bond; other site
196162001054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162001055	NAD(P) binding site [chemical binding]; other site
196162001056	active site
196162001057	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
196162001058	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196162001059	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
196162001060	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
196162001061	tetramer interface [polypeptide binding]; other site
196162001062	active site
196162001063	Mg2+/Mn2+ binding site [ion binding]; other site
196162001064	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
196162001065	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162001066	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162001067	active site
196162001068	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
196162001069	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
196162001070	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
196162001071	active site
196162001072	Fe binding site [ion binding]; other site
196162001073	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162001074	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162001075	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162001076	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162001077	active site
196162001078	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
196162001079	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
196162001080	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196162001081	Part of AAA domain; Region: AAA_19; pfam13245
196162001082	Family description; Region: UvrD_C_2; pfam13538
196162001083	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162001084	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162001085	Walker A/P-loop; other site
196162001086	ATP binding site [chemical binding]; other site
196162001087	Q-loop/lid; other site
196162001088	ABC transporter signature motif; other site
196162001089	Walker B; other site
196162001090	D-loop; other site
196162001091	H-loop/switch region; other site
196162001092	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162001093	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162001094	TM-ABC transporter signature motif; other site
196162001095	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162001096	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162001097	Walker A/P-loop; other site
196162001098	ATP binding site [chemical binding]; other site
196162001099	Q-loop/lid; other site
196162001100	ABC transporter signature motif; other site
196162001101	Walker B; other site
196162001102	D-loop; other site
196162001103	H-loop/switch region; other site
196162001104	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162001105	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162001106	TM-ABC transporter signature motif; other site
196162001107	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162001108	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162001109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162001110	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162001111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162001112	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
196162001113	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162001114	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
196162001115	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162001116	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162001117	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
196162001118	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
196162001119	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162001120	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
196162001121	Ligand binding site; other site
196162001122	metal-binding site
196162001123	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196162001124	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162001125	LysR substrate binding domain; Region: LysR_substrate; pfam03466
196162001126	dimerization interface [polypeptide binding]; other site
196162001127	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162001128	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
196162001129	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162001130	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162001131	catalytic loop [active]
196162001132	iron binding site [ion binding]; other site
196162001133	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162001134	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
196162001135	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162001136	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162001137	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
196162001138	XdhC Rossmann domain; Region: XdhC_C; pfam13478
196162001139	metallochaperone-like domain; Region: TRASH; smart00746
196162001140	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
196162001141	putative hydrophobic ligand binding site [chemical binding]; other site
196162001142	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
196162001143	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
196162001144	metal ion-dependent adhesion site (MIDAS); other site
196162001145	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162001146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162001147	Walker A motif; other site
196162001148	ATP binding site [chemical binding]; other site
196162001149	Walker B motif; other site
196162001150	arginine finger; other site
196162001151	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162001152	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162001153	active site
196162001154	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162001155	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
196162001156	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
196162001157	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
196162001158	trimer interface [polypeptide binding]; other site
196162001159	active site
196162001160	substrate binding site [chemical binding]; other site
196162001161	CoA binding site [chemical binding]; other site
196162001162	Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656
196162001163	GAF domain; Region: GAF; pfam01590
196162001164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162001165	dimer interface [polypeptide binding]; other site
196162001166	phosphorylation site [posttranslational modification]
196162001167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162001168	ATP binding site [chemical binding]; other site
196162001169	Mg2+ binding site [ion binding]; other site
196162001170	G-X-G motif; other site
196162001171	Cupin domain; Region: Cupin_2; pfam07883
196162001172	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162001173	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162001174	Walker A/P-loop; other site
196162001175	ATP binding site [chemical binding]; other site
196162001176	Q-loop/lid; other site
196162001177	ABC transporter signature motif; other site
196162001178	Walker B; other site
196162001179	D-loop; other site
196162001180	H-loop/switch region; other site
196162001181	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
196162001182	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
196162001183	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
196162001184	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
196162001185	Family description; Region: UvrD_C_2; pfam13538
196162001186	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
196162001187	AAA domain; Region: AAA_30; pfam13604
196162001188	Family description; Region: UvrD_C_2; pfam13538
196162001189	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
196162001190	transcriptional activator RfaH; Region: RfaH; TIGR01955
196162001191	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196162001192	Domain of unknown function (DUF385); Region: DUF385; pfam04075
196162001193	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
196162001194	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162001195	substrate binding site [chemical binding]; other site
196162001196	oxyanion hole (OAH) forming residues; other site
196162001197	trimer interface [polypeptide binding]; other site
196162001198	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
196162001199	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
196162001200	homodimer interface [polypeptide binding]; other site
196162001201	ligand binding site [chemical binding]; other site
196162001202	NAD(P) binding site [chemical binding]; other site
196162001203	trimer interface B [polypeptide binding]; other site
196162001204	trimer interface A [polypeptide binding]; other site
196162001205	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
196162001206	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
196162001207	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
196162001208	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
196162001209	G1 box; other site
196162001210	GTP/Mg2+ binding site [chemical binding]; other site
196162001211	G2 box; other site
196162001212	Switch I region; other site
196162001213	G3 box; other site
196162001214	Switch II region; other site
196162001215	G4 box; other site
196162001216	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
196162001217	NAD-dependent deacetylase; Provisional; Region: PRK00481
196162001218	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
196162001219	NAD+ binding site [chemical binding]; other site
196162001220	substrate binding site [chemical binding]; other site
196162001221	Zn binding site [ion binding]; other site
196162001222	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
196162001223	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
196162001224	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
196162001225	catalytic site [active]
196162001226	active site
196162001227	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
196162001228	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
196162001229	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
196162001230	active site
196162001231	catalytic site [active]
196162001232	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
196162001233	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
196162001234	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
196162001235	active site
196162001236	catalytic site [active]
196162001237	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196162001238	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162001239	putative substrate translocation pore; other site
196162001240	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162001241	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162001242	active site
196162001243	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
196162001244	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
196162001245	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
196162001246	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196162001247	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
196162001248	synthetase active site [active]
196162001249	NTP binding site [chemical binding]; other site
196162001250	metal binding site [ion binding]; metal-binding site
196162001251	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162001252	active site
196162001253	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
196162001254	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
196162001255	nucleoside/Zn binding site; other site
196162001256	dimer interface [polypeptide binding]; other site
196162001257	catalytic motif [active]
196162001258	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
196162001259	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162001260	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
196162001261	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
196162001262	active site
196162001263	FMN binding site [chemical binding]; other site
196162001264	substrate binding site [chemical binding]; other site
196162001265	3Fe-4S cluster binding site [ion binding]; other site
196162001266	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
196162001267	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
196162001268	active site
196162001269	substrate binding site [chemical binding]; other site
196162001270	FMN binding site [chemical binding]; other site
196162001271	putative catalytic residues [active]
196162001272	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
196162001273	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
196162001274	Domain of unknown function (DUF1876); Region: DUF1876; pfam08962
196162001275	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
196162001276	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
196162001277	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
196162001278	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
196162001279	trimer interface [polypeptide binding]; other site
196162001280	putative metal binding site [ion binding]; other site
196162001281	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
196162001282	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162001283	substrate binding site [chemical binding]; other site
196162001284	oxyanion hole (OAH) forming residues; other site
196162001285	trimer interface [polypeptide binding]; other site
196162001286	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162001287	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162001288	Walker A motif; other site
196162001289	ATP binding site [chemical binding]; other site
196162001290	Walker B motif; other site
196162001291	arginine finger; other site
196162001292	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
196162001293	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
196162001294	aspartate aminotransferase; Provisional; Region: PRK05764
196162001295	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162001296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162001297	homodimer interface [polypeptide binding]; other site
196162001298	catalytic residue [active]
196162001299	hypothetical protein; Validated; Region: PRK07121
196162001300	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196162001301	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162001302	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162001303	catalytic residues [active]
196162001304	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
196162001305	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
196162001306	TrkA-C domain; Region: TrkA_C; pfam02080
196162001307	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
196162001308	Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450
196162001309	SnoaL-like domain; Region: SnoaL_4; pfam13577
196162001310	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
196162001311	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196162001312	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
196162001313	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196162001314	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196162001315	Proteins of 100 residues with WXG; Region: WXG100; cl02005
196162001316	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
196162001317	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817
196162001318	Protein of unknown function (DUF690); Region: DUF690; cl04939
196162001319	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
196162001320	catalytic residues [active]
196162001321	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
196162001322	catalytic residues [active]
196162001323	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
196162001324	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
196162001325	Multicopper oxidase; Region: Cu-oxidase; pfam00394
196162001326	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
196162001327	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162001328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162001329	active site
196162001330	phosphorylation site [posttranslational modification]
196162001331	intermolecular recognition site; other site
196162001332	dimerization interface [polypeptide binding]; other site
196162001333	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162001334	DNA binding site [nucleotide binding]
196162001335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162001336	dimer interface [polypeptide binding]; other site
196162001337	phosphorylation site [posttranslational modification]
196162001338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162001339	ATP binding site [chemical binding]; other site
196162001340	Mg2+ binding site [ion binding]; other site
196162001341	G-X-G motif; other site
196162001342	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
196162001343	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196162001344	metal-binding site [ion binding]
196162001345	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162001346	Domain of unknown function (DUF305); Region: DUF305; pfam03713
196162001347	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
196162001348	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
196162001349	Moco binding site; other site
196162001350	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
196162001351	metal coordination site [ion binding]; other site
196162001352	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
196162001353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162001354	Walker A motif; other site
196162001355	ATP binding site [chemical binding]; other site
196162001356	Walker B motif; other site
196162001357	arginine finger; other site
196162001358	recombination protein RecR; Reviewed; Region: recR; PRK00076
196162001359	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
196162001360	RecR protein; Region: RecR; pfam02132
196162001361	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
196162001362	putative active site [active]
196162001363	putative metal-binding site [ion binding]; other site
196162001364	tetramer interface [polypeptide binding]; other site
196162001365	aspartate kinase; Reviewed; Region: PRK06635
196162001366	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
196162001367	putative nucleotide binding site [chemical binding]; other site
196162001368	putative catalytic residues [active]
196162001369	putative Mg ion binding site [ion binding]; other site
196162001370	putative aspartate binding site [chemical binding]; other site
196162001371	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
196162001372	putative allosteric regulatory site; other site
196162001373	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
196162001374	putative allosteric regulatory residue; other site
196162001375	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
196162001376	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
196162001377	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
196162001378	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196162001379	putative active site [active]
196162001380	putative metal binding site [ion binding]; other site
196162001381	Yqey-like protein; Region: YqeY; pfam09424
196162001382	Transglycosylase; Region: Transgly; pfam00912
196162001383	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
196162001384	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
196162001385	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162001386	Transcription factor WhiB; Region: Whib; pfam02467
196162001387	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
196162001388	transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345
196162001389	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
196162001390	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
196162001391	DTAP/Switch II; other site
196162001392	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
196162001393	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
196162001394	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
196162001395	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162001396	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162001397	DNA binding residues [nucleotide binding]
196162001398	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
196162001399	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162001400	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162001401	DNA binding residues [nucleotide binding]
196162001402	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
196162001403	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
196162001404	homotrimer interaction site [polypeptide binding]; other site
196162001405	putative active site [active]
196162001406	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
196162001407	nudix motif; other site
196162001408	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
196162001409	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196162001410	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196162001411	ligand binding site [chemical binding]; other site
196162001412	flexible hinge region; other site
196162001413	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196162001414	putative switch regulator; other site
196162001415	non-specific DNA interactions [nucleotide binding]; other site
196162001416	DNA binding site [nucleotide binding]
196162001417	sequence specific DNA binding site [nucleotide binding]; other site
196162001418	putative cAMP binding site [chemical binding]; other site
196162001419	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
196162001420	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
196162001421	minor groove reading motif; other site
196162001422	helix-hairpin-helix signature motif; other site
196162001423	substrate binding pocket [chemical binding]; other site
196162001424	active site
196162001425	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
196162001426	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162001427	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162001428	catalytic residues [active]
196162001429	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
196162001430	putative active site [active]
196162001431	putative CoA binding site [chemical binding]; other site
196162001432	nudix motif; other site
196162001433	metal binding site [ion binding]; metal-binding site
196162001434	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
196162001435	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196162001436	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
196162001437	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
196162001438	acetyl-CoA synthetase; Provisional; Region: PRK00174
196162001439	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
196162001440	active site
196162001441	CoA binding site [chemical binding]; other site
196162001442	acyl-activating enzyme (AAE) consensus motif; other site
196162001443	AMP binding site [chemical binding]; other site
196162001444	acetate binding site [chemical binding]; other site
196162001445	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
196162001446	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
196162001447	Na binding site [ion binding]; other site
196162001448	Protein of unknown function, DUF485; Region: DUF485; pfam04341
196162001449	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
196162001450	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
196162001451	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
196162001452	[4Fe-4S] binding site [ion binding]; other site
196162001453	molybdopterin cofactor binding site; other site
196162001454	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
196162001455	molybdopterin cofactor binding site; other site
196162001456	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
196162001457	nitrite reductase subunit NirD; Provisional; Region: PRK14989
196162001458	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162001459	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
196162001460	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196162001461	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
196162001462	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
196162001463	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
196162001464	active site
196162001465	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
196162001466	DNA binding site [nucleotide binding]
196162001467	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
196162001468	Na binding site [ion binding]; other site
196162001469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162001470	active site
196162001471	phosphorylation site [posttranslational modification]
196162001472	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
196162001473	intermolecular recognition site; other site
196162001474	dimerization interface [polypeptide binding]; other site
196162001475	LytTr DNA-binding domain; Region: LytTR; smart00850
196162001476	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
196162001477	Histidine kinase; Region: His_kinase; pfam06580
196162001478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162001479	ATP binding site [chemical binding]; other site
196162001480	Mg2+ binding site [ion binding]; other site
196162001481	G-X-G motif; other site
196162001482	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
196162001483	active site
196162001484	zinc binding site [ion binding]; other site
196162001485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162001486	S-adenosylmethionine binding site [chemical binding]; other site
196162001487	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
196162001488	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196162001489	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
196162001490	helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819
196162001491	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196162001492	Walker A motif; other site
196162001493	ATP binding site [chemical binding]; other site
196162001494	Walker B motif; other site
196162001495	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196162001496	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
196162001497	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
196162001498	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
196162001499	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162001500	ATP binding site [chemical binding]; other site
196162001501	putative Mg++ binding site [ion binding]; other site
196162001502	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162001503	nucleotide binding region [chemical binding]; other site
196162001504	ATP-binding site [chemical binding]; other site
196162001505	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
196162001506	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
196162001507	anti sigma factor interaction site; other site
196162001508	regulatory phosphorylation site [posttranslational modification]; other site
196162001509	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
196162001510	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
196162001511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162001512	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
196162001513	S-adenosylmethionine binding site [chemical binding]; other site
196162001514	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
196162001515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162001516	DNA binding residues [nucleotide binding]
196162001517	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
196162001518	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
196162001519	active site
196162001520	interdomain interaction site; other site
196162001521	putative metal-binding site [ion binding]; other site
196162001522	nucleotide binding site [chemical binding]; other site
196162001523	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
196162001524	domain I; other site
196162001525	phosphate binding site [ion binding]; other site
196162001526	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
196162001527	domain II; other site
196162001528	domain III; other site
196162001529	nucleotide binding site [chemical binding]; other site
196162001530	DNA binding groove [nucleotide binding]
196162001531	catalytic site [active]
196162001532	domain IV; other site
196162001533	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
196162001534	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
196162001535	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
196162001536	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162001537	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162001538	DNA binding site [nucleotide binding]
196162001539	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
196162001540	ligand binding site [chemical binding]; other site
196162001541	dimerization interface (open form) [polypeptide binding]; other site
196162001542	dimerization interface (closed form) [polypeptide binding]; other site
196162001543	ribulokinase; Provisional; Region: PRK04123
196162001544	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162001545	nucleotide binding site [chemical binding]; other site
196162001546	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
196162001547	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
196162001548	intersubunit interface [polypeptide binding]; other site
196162001549	active site
196162001550	Zn2+ binding site [ion binding]; other site
196162001551	L-arabinose isomerase; Provisional; Region: PRK02929
196162001552	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
196162001553	hexamer (dimer of trimers) interface [polypeptide binding]; other site
196162001554	trimer interface [polypeptide binding]; other site
196162001555	substrate binding site [chemical binding]; other site
196162001556	Mn binding site [ion binding]; other site
196162001557	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
196162001558	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
196162001559	putative ligand binding site [chemical binding]; other site
196162001560	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162001561	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162001562	Walker A/P-loop; other site
196162001563	ATP binding site [chemical binding]; other site
196162001564	Q-loop/lid; other site
196162001565	ABC transporter signature motif; other site
196162001566	Walker B; other site
196162001567	D-loop; other site
196162001568	H-loop/switch region; other site
196162001569	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162001570	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162001571	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162001572	TM-ABC transporter signature motif; other site
196162001573	thymidylate kinase; Validated; Region: tmk; PRK00698
196162001574	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
196162001575	TMP-binding site; other site
196162001576	ATP-binding site [chemical binding]; other site
196162001577	DNA polymerase III subunit delta'; Validated; Region: PRK07940
196162001578	DNA polymerase III subunit delta'; Validated; Region: PRK08485
196162001579	TAP-like protein; Region: Abhydrolase_4; pfam08386
196162001580	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
196162001581	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162001582	Peptidase family C69; Region: Peptidase_C69; cl17793
196162001583	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
196162001584	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196162001585	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162001586	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
196162001587	dimerization interface [polypeptide binding]; other site
196162001588	YCII-related domain; Region: YCII; cl00999
196162001589	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
196162001590	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
196162001591	intersubunit interface [polypeptide binding]; other site
196162001592	active site
196162001593	Zn2+ binding site [ion binding]; other site
196162001594	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
196162001595	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
196162001596	putative active site; other site
196162001597	catalytic residue [active]
196162001598	Cupin domain; Region: Cupin_2; pfam07883
196162001599	short chain dehydrogenase; Validated; Region: PRK08324
196162001600	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
196162001601	active site
196162001602	Zn2+ binding site [ion binding]; other site
196162001603	intersubunit interface [polypeptide binding]; other site
196162001604	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162001605	NAD(P) binding site [chemical binding]; other site
196162001606	active site
196162001607	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
196162001608	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162001609	DNA-binding site [nucleotide binding]; DNA binding site
196162001610	UTRA domain; Region: UTRA; pfam07702
196162001611	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
196162001612	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
196162001613	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
196162001614	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162001615	putative ligand binding site [chemical binding]; other site
196162001616	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162001617	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162001618	Walker A/P-loop; other site
196162001619	ATP binding site [chemical binding]; other site
196162001620	Q-loop/lid; other site
196162001621	ABC transporter signature motif; other site
196162001622	Walker B; other site
196162001623	D-loop; other site
196162001624	H-loop/switch region; other site
196162001625	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162001626	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162001627	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162001628	TM-ABC transporter signature motif; other site
196162001629	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
196162001630	short chain dehydrogenase; Provisional; Region: PRK07454
196162001631	classical (c) SDRs; Region: SDR_c; cd05233
196162001632	NAD(P) binding site [chemical binding]; other site
196162001633	active site
196162001634	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
196162001635	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
196162001636	putative active site [active]
196162001637	redox center [active]
196162001638	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
196162001639	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
196162001640	catalytic residues [active]
196162001641	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
196162001642	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
196162001643	Uncharacterized conserved protein [Function unknown]; Region: COG1284
196162001644	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
196162001645	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
196162001646	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
196162001647	RNA/DNA hybrid binding site [nucleotide binding]; other site
196162001648	active site
196162001649	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162001650	putative catalytic site [active]
196162001651	putative metal binding site [ion binding]; other site
196162001652	putative phosphate binding site [ion binding]; other site
196162001653	Predicted transcriptional regulators [Transcription]; Region: COG1733
196162001654	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
196162001655	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
196162001656	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
196162001657	NADP binding site [chemical binding]; other site
196162001658	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
196162001659	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162001660	S-adenosylmethionine binding site [chemical binding]; other site
196162001661	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
196162001662	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
196162001663	active site
196162001664	FMN binding site [chemical binding]; other site
196162001665	substrate binding site [chemical binding]; other site
196162001666	putative catalytic residue [active]
196162001667	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
196162001668	short chain dehydrogenase; Provisional; Region: PRK07814
196162001669	classical (c) SDRs; Region: SDR_c; cd05233
196162001670	NAD(P) binding site [chemical binding]; other site
196162001671	active site
196162001672	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162001673	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162001674	Coenzyme A binding pocket [chemical binding]; other site
196162001675	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
196162001676	Uncharacterized conserved protein [Function unknown]; Region: COG2128
196162001677	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
196162001678	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
196162001679	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162001680	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162001681	DNA binding residues [nucleotide binding]
196162001682	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
196162001683	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162001684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162001685	dimer interface [polypeptide binding]; other site
196162001686	conserved gate region; other site
196162001687	putative PBP binding loops; other site
196162001688	ABC-ATPase subunit interface; other site
196162001689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162001690	ABC-ATPase subunit interface; other site
196162001691	putative PBP binding loops; other site
196162001692	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
196162001693	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
196162001694	Walker A/P-loop; other site
196162001695	ATP binding site [chemical binding]; other site
196162001696	Q-loop/lid; other site
196162001697	ABC transporter signature motif; other site
196162001698	Walker B; other site
196162001699	D-loop; other site
196162001700	H-loop/switch region; other site
196162001701	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162001702	active site
196162001703	acyl-coenzyme A oxidase; Region: PLN02636
196162001704	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162001705	active site
196162001706	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
196162001707	dimer interface [polypeptide binding]; other site
196162001708	substrate binding site [chemical binding]; other site
196162001709	metal binding sites [ion binding]; metal-binding site
196162001710	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
196162001711	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
196162001712	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
196162001713	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
196162001714	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
196162001715	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
196162001716	Ligand Binding Site [chemical binding]; other site
196162001717	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
196162001718	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162001719	active site
196162001720	FtsH Extracellular; Region: FtsH_ext; pfam06480
196162001721	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
196162001722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162001723	Walker A motif; other site
196162001724	ATP binding site [chemical binding]; other site
196162001725	Walker B motif; other site
196162001726	arginine finger; other site
196162001727	Peptidase family M41; Region: Peptidase_M41; pfam01434
196162001728	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
196162001729	GTP cyclohydrolase I; Provisional; Region: PLN03044
196162001730	homodecamer interface [polypeptide binding]; other site
196162001731	active site
196162001732	putative catalytic site residues [active]
196162001733	zinc binding site [ion binding]; other site
196162001734	GTP-CH-I/GFRP interaction surface; other site
196162001735	dihydropteroate synthase; Region: DHPS; TIGR01496
196162001736	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
196162001737	substrate binding pocket [chemical binding]; other site
196162001738	dimer interface [polypeptide binding]; other site
196162001739	inhibitor binding site; inhibition site
196162001740	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
196162001741	homooctamer interface [polypeptide binding]; other site
196162001742	active site
196162001743	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
196162001744	catalytic center binding site [active]
196162001745	ATP binding site [chemical binding]; other site
196162001746	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
196162001747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162001748	Coenzyme A binding pocket [chemical binding]; other site
196162001749	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
196162001750	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
196162001751	Walker A/P-loop; other site
196162001752	ATP binding site [chemical binding]; other site
196162001753	Q-loop/lid; other site
196162001754	ABC transporter signature motif; other site
196162001755	Walker B; other site
196162001756	D-loop; other site
196162001757	H-loop/switch region; other site
196162001758	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
196162001759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
196162001760	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
196162001761	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
196162001762	active site
196162001763	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
196162001764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162001765	active site
196162001766	Rossmann-like domain; Region: Rossmann-like; pfam10727
196162001767	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
196162001768	Pantoate-beta-alanine ligase; Region: PanC; cd00560
196162001769	pantoate--beta-alanine ligase; Region: panC; TIGR00018
196162001770	active site
196162001771	ATP-binding site [chemical binding]; other site
196162001772	pantoate-binding site; other site
196162001773	HXXH motif; other site
196162001774	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
196162001775	tetramerization interface [polypeptide binding]; other site
196162001776	active site
196162001777	L-aspartate oxidase; Provisional; Region: PRK07804
196162001778	L-aspartate oxidase; Provisional; Region: PRK06175
196162001779	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
196162001780	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
196162001781	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
196162001782	dimerization interface [polypeptide binding]; other site
196162001783	active site
196162001784	pantothenate kinase; Reviewed; Region: PRK13318
196162001785	Lsr2; Region: Lsr2; pfam11774
196162001786	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
196162001787	Clp amino terminal domain; Region: Clp_N; pfam02861
196162001788	Clp amino terminal domain; Region: Clp_N; pfam02861
196162001789	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162001790	Walker A motif; other site
196162001791	ATP binding site [chemical binding]; other site
196162001792	Walker B motif; other site
196162001793	arginine finger; other site
196162001794	UvrB/uvrC motif; Region: UVR; pfam02151
196162001795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162001796	Walker A motif; other site
196162001797	ATP binding site [chemical binding]; other site
196162001798	Walker B motif; other site
196162001799	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
196162001800	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
196162001801	endonuclease III; Region: ENDO3c; smart00478
196162001802	minor groove reading motif; other site
196162001803	helix-hairpin-helix signature motif; other site
196162001804	substrate binding pocket [chemical binding]; other site
196162001805	active site
196162001806	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
196162001807	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
196162001808	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
196162001809	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
196162001810	DNA repair protein RadA; Provisional; Region: PRK11823
196162001811	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
196162001812	Walker A motif; other site
196162001813	ATP binding site [chemical binding]; other site
196162001814	Walker B motif; other site
196162001815	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
196162001816	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162001817	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162001818	DNA binding site [nucleotide binding]
196162001819	domain linker motif; other site
196162001820	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
196162001821	ligand binding site [chemical binding]; other site
196162001822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162001823	S-adenosylmethionine binding site [chemical binding]; other site
196162001824	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
196162001825	exopolyphosphatase; Region: exo_poly_only; TIGR03706
196162001826	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
196162001827	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
196162001828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162001829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162001830	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
196162001831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162001832	Walker A/P-loop; other site
196162001833	ATP binding site [chemical binding]; other site
196162001834	Q-loop/lid; other site
196162001835	ABC transporter signature motif; other site
196162001836	Walker B; other site
196162001837	D-loop; other site
196162001838	H-loop/switch region; other site
196162001839	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
196162001840	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196162001841	Proline dehydrogenase; Region: Pro_dh; cl03282
196162001842	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
196162001843	pyrroline-5-carboxylate reductase; Region: PLN02688
196162001844	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
196162001845	active site
196162001846	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
196162001847	HIGH motif; other site
196162001848	dimer interface [polypeptide binding]; other site
196162001849	KMSKS motif; other site
196162001850	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
196162001851	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
196162001852	active site
196162001853	Zn binding site [ion binding]; other site
196162001854	DNA binding domain, excisionase family; Region: excise; TIGR01764
196162001855	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
196162001856	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
196162001857	putative NAD(P) binding site [chemical binding]; other site
196162001858	active site
196162001859	putative substrate binding site [chemical binding]; other site
196162001860	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162001861	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
196162001862	putative acyl-acceptor binding pocket; other site
196162001863	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
196162001864	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162001865	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162001866	DNA binding residues [nucleotide binding]
196162001867	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
196162001868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162001869	motif II; other site
196162001870	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
196162001871	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162001872	acyl-activating enzyme (AAE) consensus motif; other site
196162001873	AMP binding site [chemical binding]; other site
196162001874	active site
196162001875	CoA binding site [chemical binding]; other site
196162001876	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
196162001877	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
196162001878	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
196162001879	CoA binding domain; Region: CoA_binding; pfam02629
196162001880	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
196162001881	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
196162001882	tRNA; other site
196162001883	putative tRNA binding site [nucleotide binding]; other site
196162001884	putative NADP binding site [chemical binding]; other site
196162001885	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
196162001886	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
196162001887	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
196162001888	domain interfaces; other site
196162001889	active site
196162001890	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
196162001891	active site
196162001892	SAM binding site [chemical binding]; other site
196162001893	homodimer interface [polypeptide binding]; other site
196162001894	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
196162001895	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
196162001896	active site
196162001897	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
196162001898	dimer interface [polypeptide binding]; other site
196162001899	active site
196162001900	Schiff base residues; other site
196162001901	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
196162001902	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
196162001903	N-acetyl-D-glucosamine binding site [chemical binding]; other site
196162001904	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
196162001905	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162001906	inhibitor-cofactor binding pocket; inhibition site
196162001907	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162001908	catalytic residue [active]
196162001909	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162001910	catalytic core [active]
196162001911	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162001912	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162001913	catalytic residues [active]
196162001914	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196162001915	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
196162001916	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
196162001917	ResB-like family; Region: ResB; pfam05140
196162001918	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
196162001919	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
196162001920	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
196162001921	UbiA prenyltransferase family; Region: UbiA; pfam01040
196162001922	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162001923	acyl-activating enzyme (AAE) consensus motif; other site
196162001924	AMP binding site [chemical binding]; other site
196162001925	active site
196162001926	CoA binding site [chemical binding]; other site
196162001927	O-succinylbenzoate synthase; Provisional; Region: PRK02901
196162001928	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
196162001929	active site
196162001930	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
196162001931	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
196162001932	dimer interface [polypeptide binding]; other site
196162001933	tetramer interface [polypeptide binding]; other site
196162001934	PYR/PP interface [polypeptide binding]; other site
196162001935	TPP binding site [chemical binding]; other site
196162001936	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
196162001937	TPP-binding site; other site
196162001938	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
196162001939	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
196162001940	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162001941	Cytochrome P450; Region: p450; cl12078
196162001942	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
196162001943	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162001944	Coenzyme A binding pocket [chemical binding]; other site
196162001945	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
196162001946	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
196162001947	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
196162001948	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
196162001949	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
196162001950	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
196162001951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162001952	S-adenosylmethionine binding site [chemical binding]; other site
196162001953	NADH dehydrogenase subunit A; Validated; Region: PRK07928
196162001954	NADH dehydrogenase subunit B; Validated; Region: PRK06411
196162001955	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
196162001956	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
196162001957	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
196162001958	NADH dehydrogenase subunit D; Validated; Region: PRK06075
196162001959	NADH dehydrogenase subunit E; Validated; Region: PRK07539
196162001960	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
196162001961	putative dimer interface [polypeptide binding]; other site
196162001962	[2Fe-2S] cluster binding site [ion binding]; other site
196162001963	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
196162001964	SLBB domain; Region: SLBB; pfam10531
196162001965	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
196162001966	NADH dehydrogenase subunit G; Validated; Region: PRK07860
196162001967	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162001968	catalytic loop [active]
196162001969	iron binding site [ion binding]; other site
196162001970	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
196162001971	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196162001972	molybdopterin cofactor binding site; other site
196162001973	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
196162001974	molybdopterin cofactor binding site; other site
196162001975	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
196162001976	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
196162001977	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
196162001978	4Fe-4S binding domain; Region: Fer4; pfam00037
196162001979	4Fe-4S binding domain; Region: Fer4; pfam00037
196162001980	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
196162001981	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
196162001982	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
196162001983	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
196162001984	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
196162001985	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196162001986	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
196162001987	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196162001988	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
196162001989	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196162001990	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
196162001991	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
196162001992	substrate binding pocket [chemical binding]; other site
196162001993	chain length determination region; other site
196162001994	substrate-Mg2+ binding site; other site
196162001995	catalytic residues [active]
196162001996	aspartate-rich region 1; other site
196162001997	active site lid residues [active]
196162001998	aspartate-rich region 2; other site
196162001999	Predicted permeases [General function prediction only]; Region: RarD; COG2962
196162002000	EamA-like transporter family; Region: EamA; pfam00892
196162002001	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
196162002002	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
196162002003	TPP-binding site [chemical binding]; other site
196162002004	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
196162002005	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
196162002006	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
196162002007	dimer interface [polypeptide binding]; other site
196162002008	PYR/PP interface [polypeptide binding]; other site
196162002009	TPP binding site [chemical binding]; other site
196162002010	substrate binding site [chemical binding]; other site
196162002011	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162002012	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
196162002013	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
196162002014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162002015	dimer interface [polypeptide binding]; other site
196162002016	conserved gate region; other site
196162002017	ABC-ATPase subunit interface; other site
196162002018	sulfate transport protein; Provisional; Region: cysT; CHL00187
196162002019	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162002020	dimer interface [polypeptide binding]; other site
196162002021	conserved gate region; other site
196162002022	putative PBP binding loops; other site
196162002023	ABC-ATPase subunit interface; other site
196162002024	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
196162002025	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
196162002026	Walker A/P-loop; other site
196162002027	ATP binding site [chemical binding]; other site
196162002028	Q-loop/lid; other site
196162002029	ABC transporter signature motif; other site
196162002030	Walker B; other site
196162002031	D-loop; other site
196162002032	H-loop/switch region; other site
196162002033	TOBE-like domain; Region: TOBE_3; pfam12857
196162002034	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
196162002035	active site
196162002036	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
196162002037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162002038	DNA-binding site [nucleotide binding]; DNA binding site
196162002039	UTRA domain; Region: UTRA; pfam07702
196162002040	deoxyribose-phosphate aldolase; Provisional; Region: PRK00507
196162002041	catalytic residue [active]
196162002042	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196162002043	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
196162002044	substrate binding site [chemical binding]; other site
196162002045	dimer interface [polypeptide binding]; other site
196162002046	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
196162002047	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162002048	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
196162002049	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162002050	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162002051	hypothetical protein; Validated; Region: PRK08116
196162002052	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
196162002053	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162002054	active site
196162002055	DNA binding site [nucleotide binding]
196162002056	Int/Topo IB signature motif; other site
196162002057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
196162002058	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
196162002059	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162002060	active site
196162002061	catalytic residues [active]
196162002062	DNA binding site [nucleotide binding]
196162002063	Int/Topo IB signature motif; other site
196162002064	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162002065	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196162002066	dimer interface [polypeptide binding]; other site
196162002067	ssDNA binding site [nucleotide binding]; other site
196162002068	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196162002069	Helix-turn-helix domain; Region: HTH_38; pfam13936
196162002070	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196162002071	Integrase core domain; Region: rve; pfam00665
196162002072	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
196162002073	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162002074	FeS/SAM binding site; other site
196162002075	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
196162002076	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
196162002077	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
196162002078	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162002079	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162002080	NAD(P) binding site [chemical binding]; other site
196162002081	active site
196162002082	SnoaL-like domain; Region: SnoaL_2; pfam12680
196162002083	Domain of unknown function (DUF336); Region: DUF336; cl01249
196162002084	Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain.  TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929
196162002085	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
196162002086	FMN binding site [chemical binding]; other site
196162002087	active site
196162002088	homodimer interface [polypeptide binding]; other site
196162002089	putative catalytic residue [active]
196162002090	4Fe-4S cluster binding site [ion binding]; other site
196162002091	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162002092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
196162002093	Integrase core domain; Region: rve; pfam00665
196162002094	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
196162002095	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162002096	Walker A motif; other site
196162002097	ATP binding site [chemical binding]; other site
196162002098	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
196162002099	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
196162002100	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162002101	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
196162002102	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162002103	ligand binding site [chemical binding]; other site
196162002104	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
196162002105	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162002106	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
196162002107	Putative cyclase; Region: Cyclase; pfam04199
196162002108	hypothetical protein; Provisional; Region: PRK07236
196162002109	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
196162002110	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
196162002111	putative hydrophobic ligand binding site [chemical binding]; other site
196162002112	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162002113	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
196162002114	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162002115	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162002116	catalytic loop [active]
196162002117	iron binding site [ion binding]; other site
196162002118	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162002119	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162002120	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162002121	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162002122	Predicted amidohydrolase [General function prediction only]; Region: COG0388
196162002123	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
196162002124	putative active site [active]
196162002125	catalytic triad [active]
196162002126	putative dimer interface [polypeptide binding]; other site
196162002127	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
196162002128	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
196162002129	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162002130	active site
196162002131	DNA binding site [nucleotide binding]
196162002132	Int/Topo IB signature motif; other site
196162002133	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162002134	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
196162002135	active site
196162002136	DNA binding site [nucleotide binding]
196162002137	Int/Topo IB signature motif; other site
196162002138	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196162002139	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162002140	active site
196162002141	DNA binding site [nucleotide binding]
196162002142	Int/Topo IB signature motif; other site
196162002143	Integrase core domain; Region: rve; pfam00665
196162002144	Integrase core domain; Region: rve_2; pfam13333
196162002145	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
196162002146	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162002147	ligand binding site [chemical binding]; other site
196162002148	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162002149	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162002150	catalytic loop [active]
196162002151	iron binding site [ion binding]; other site
196162002152	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162002153	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162002154	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
196162002155	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
196162002156	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162002157	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162002158	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162002159	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162002160	TM-ABC transporter signature motif; other site
196162002161	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162002162	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162002163	Walker A/P-loop; other site
196162002164	ATP binding site [chemical binding]; other site
196162002165	Q-loop/lid; other site
196162002166	ABC transporter signature motif; other site
196162002167	Walker B; other site
196162002168	D-loop; other site
196162002169	H-loop/switch region; other site
196162002170	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162002171	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162002172	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162002173	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162002174	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162002175	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162002176	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
196162002177	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196162002178	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
196162002179	phosphate binding site [ion binding]; other site
196162002180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162002181	EamA-like transporter family; Region: EamA; pfam00892
196162002182	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
196162002183	EamA-like transporter family; Region: EamA; pfam00892
196162002184	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196162002185	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162002186	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
196162002187	putative dimerization interface [polypeptide binding]; other site
196162002188	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
196162002189	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
196162002190	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162002191	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
196162002192	Transposase, Mutator family; Region: Transposase_mut; pfam00872
196162002193	MULE transposase domain; Region: MULE; pfam10551
196162002194	Transposase, Mutator family; Region: Transposase_mut; pfam00872
196162002195	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162002196	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
196162002197	Walker A motif; other site
196162002198	ATP binding site [chemical binding]; other site
196162002199	Walker B motif; other site
196162002200	arginine finger; other site
196162002201	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
196162002202	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
196162002203	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
196162002204	XdhC Rossmann domain; Region: XdhC_C; pfam13478
196162002205	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
196162002206	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162002207	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
196162002208	4Fe-4S binding domain; Region: Fer4; pfam00037
196162002209	ferredoxin-NADP+ reductase; Region: PLN02852
196162002210	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162002211	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
196162002212	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196162002213	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
196162002214	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162002215	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
196162002216	dihydropteroate synthase; Region: DHPS; TIGR01496
196162002217	substrate binding pocket [chemical binding]; other site
196162002218	dimer interface [polypeptide binding]; other site
196162002219	inhibitor binding site; inhibition site
196162002220	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
196162002221	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
196162002222	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
196162002223	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
196162002224	Ligand binding site [chemical binding]; other site
196162002225	Electron transfer flavoprotein domain; Region: ETF; pfam01012
196162002226	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
196162002227	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
196162002228	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
196162002229	homodimer interface [polypeptide binding]; other site
196162002230	NADP binding site [chemical binding]; other site
196162002231	substrate binding site [chemical binding]; other site
196162002232	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162002233	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162002234	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
196162002235	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
196162002236	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
196162002237	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
196162002238	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
196162002239	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
196162002240	putative active site [active]
196162002241	putative substrate binding site [chemical binding]; other site
196162002242	putative cosubstrate binding site; other site
196162002243	catalytic site [active]
196162002244	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196162002245	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162002246	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
196162002247	dimerization interface [polypeptide binding]; other site
196162002248	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
196162002249	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162002250	inhibitor-cofactor binding pocket; inhibition site
196162002251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162002252	catalytic residue [active]
196162002253	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162002254	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196162002255	tetramerization interface [polypeptide binding]; other site
196162002256	NAD(P) binding site [chemical binding]; other site
196162002257	catalytic residues [active]
196162002258	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162002259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162002260	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
196162002261	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
196162002262	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
196162002263	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
196162002264	active site
196162002265	metal binding site [ion binding]; metal-binding site
196162002266	hexamer interface [polypeptide binding]; other site
196162002267	Domain of unknown function (DUF385); Region: DUF385; cl04387
196162002268	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
196162002269	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162002270	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
196162002271	fumarylacetoacetase; Region: PLN02856
196162002272	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
196162002273	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196162002274	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
196162002275	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162002276	active site
196162002277	catalytic tetrad [active]
196162002278	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162002279	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
196162002280	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
196162002281	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
196162002282	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
196162002283	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
196162002284	putative molybdopterin cofactor binding site [chemical binding]; other site
196162002285	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
196162002286	putative molybdopterin cofactor binding site; other site
196162002287	Pirin-related protein [General function prediction only]; Region: COG1741
196162002288	Pirin; Region: Pirin; pfam02678
196162002289	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
196162002290	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
196162002291	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162002292	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162002293	amidase; Provisional; Region: PRK07869
196162002294	Amidase; Region: Amidase; cl11426
196162002295	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
196162002296	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
196162002297	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
196162002298	active site
196162002299	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162002300	active site 2 [active]
196162002301	active site 1 [active]
196162002302	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
196162002303	FAD binding domain; Region: FAD_binding_4; pfam01565
196162002304	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
196162002305	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
196162002306	adenosine deaminase; Provisional; Region: PRK09358
196162002307	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
196162002308	active site
196162002309	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
196162002310	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162002311	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162002312	catalytic residue [active]
196162002313	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162002314	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
196162002315	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
196162002316	active site
196162002317	putative substrate binding pocket [chemical binding]; other site
196162002318	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162002319	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162002320	Walker A/P-loop; other site
196162002321	ATP binding site [chemical binding]; other site
196162002322	Q-loop/lid; other site
196162002323	ABC transporter signature motif; other site
196162002324	Walker B; other site
196162002325	D-loop; other site
196162002326	H-loop/switch region; other site
196162002327	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162002328	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
196162002329	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162002330	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162002331	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162002332	TM-ABC transporter signature motif; other site
196162002333	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
196162002334	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162002335	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162002336	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
196162002337	[2Fe-2S] cluster binding site [ion binding]; other site
196162002338	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
196162002339	beta subunit interface [polypeptide binding]; other site
196162002340	alpha subunit interface [polypeptide binding]; other site
196162002341	active site
196162002342	substrate binding site [chemical binding]; other site
196162002343	Fe binding site [ion binding]; other site
196162002344	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
196162002345	inter-subunit interface; other site
196162002346	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
196162002347	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162002348	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
196162002349	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162002350	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162002351	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
196162002352	N-terminal, non-catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Rhodococcus rhodochrous K37, and similar proteins; Region: BphC5-RrK37_N_like; cd08362
196162002353	putative oligomer interface [polypeptide binding]; other site
196162002354	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
196162002355	active site
196162002356	metal binding site [ion binding]; metal-binding site
196162002357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162002358	NAD(P) binding site [chemical binding]; other site
196162002359	active site
196162002360	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196162002361	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
196162002362	active site
196162002363	inhibitor site; inhibition site
196162002364	dimer interface [polypeptide binding]; other site
196162002365	catalytic residue [active]
196162002366	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
196162002367	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162002368	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196162002369	tetramerization interface [polypeptide binding]; other site
196162002370	NAD(P) binding site [chemical binding]; other site
196162002371	catalytic residues [active]
196162002372	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196162002373	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162002374	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
196162002375	substrate binding pocket [chemical binding]; other site
196162002376	dimerization interface [polypeptide binding]; other site
196162002377	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
196162002378	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
196162002379	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
196162002380	putative homodimer interface [polypeptide binding]; other site
196162002381	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
196162002382	heterodimer interface [polypeptide binding]; other site
196162002383	homodimer interface [polypeptide binding]; other site
196162002384	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
196162002385	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
196162002386	23S rRNA interface [nucleotide binding]; other site
196162002387	L7/L12 interface [polypeptide binding]; other site
196162002388	putative thiostrepton binding site; other site
196162002389	L25 interface [polypeptide binding]; other site
196162002390	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
196162002391	mRNA/rRNA interface [nucleotide binding]; other site
196162002392	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
196162002393	23S rRNA interface [nucleotide binding]; other site
196162002394	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
196162002395	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
196162002396	core dimer interface [polypeptide binding]; other site
196162002397	peripheral dimer interface [polypeptide binding]; other site
196162002398	L10 interface [polypeptide binding]; other site
196162002399	L11 interface [polypeptide binding]; other site
196162002400	putative EF-Tu interaction site [polypeptide binding]; other site
196162002401	putative EF-G interaction site [polypeptide binding]; other site
196162002402	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
196162002403	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
196162002404	Walker A/P-loop; other site
196162002405	ATP binding site [chemical binding]; other site
196162002406	Q-loop/lid; other site
196162002407	ABC transporter signature motif; other site
196162002408	Walker B; other site
196162002409	D-loop; other site
196162002410	H-loop/switch region; other site
196162002411	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
196162002412	Permease; Region: Permease; pfam02405
196162002413	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
196162002414	Permease; Region: Permease; pfam02405
196162002415	mce related protein; Region: MCE; pfam02470
196162002416	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
196162002417	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162002418	mce related protein; Region: MCE; pfam02470
196162002419	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162002420	mce related protein; Region: MCE; pfam02470
196162002421	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
196162002422	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162002423	mce related protein; Region: MCE; pfam02470
196162002424	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162002425	mce related protein; Region: MCE; pfam02470
196162002426	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
196162002427	mce related protein; Region: MCE; pfam02470
196162002428	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
196162002429	DnaJ domain; Region: DnaJ; pfam00226
196162002430	HSP70 interaction site [polypeptide binding]; other site
196162002431	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
196162002432	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
196162002433	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
196162002434	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
196162002435	RPB1 interaction site [polypeptide binding]; other site
196162002436	RPB10 interaction site [polypeptide binding]; other site
196162002437	RPB11 interaction site [polypeptide binding]; other site
196162002438	RPB3 interaction site [polypeptide binding]; other site
196162002439	RPB12 interaction site [polypeptide binding]; other site
196162002440	RNA polymerase beta' subunit; Region: rpoC1; CHL00018
196162002441	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
196162002442	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
196162002443	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
196162002444	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
196162002445	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
196162002446	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
196162002447	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
196162002448	G-loop; other site
196162002449	DNA binding site [nucleotide binding]
196162002450	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
196162002451	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
196162002452	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
196162002453	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
196162002454	nudix motif; other site
196162002455	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
196162002456	nudix motif; other site
196162002457	PBP superfamily domain; Region: PBP_like_2; cl17296
196162002458	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
196162002459	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
196162002460	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
196162002461	DXD motif; other site
196162002462	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
196162002463	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
196162002464	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
196162002465	active site
196162002466	NAD binding site [chemical binding]; other site
196162002467	metal binding site [ion binding]; metal-binding site
196162002468	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162002469	FAD binding domain; Region: FAD_binding_4; pfam01565
196162002470	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
196162002471	Methyltransferase domain; Region: Methyltransf_32; pfam13679
196162002472	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
196162002473	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
196162002474	active site
196162002475	DNA binding site [nucleotide binding]
196162002476	Int/Topo IB signature motif; other site
196162002477	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
196162002478	putative ADP-ribose binding site [chemical binding]; other site
196162002479	putative active site [active]
196162002480	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162002481	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162002482	catalytic residue [active]
196162002483	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196162002484	citrate synthase 2; Provisional; Region: PRK12350
196162002485	Citrate synthase; Region: Citrate_synt; pfam00285
196162002486	oxalacetate binding site [chemical binding]; other site
196162002487	citrylCoA binding site [chemical binding]; other site
196162002488	coenzyme A binding site [chemical binding]; other site
196162002489	catalytic triad [active]
196162002490	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
196162002491	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
196162002492	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
196162002493	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162002494	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162002495	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162002496	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162002497	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162002498	Walker A/P-loop; other site
196162002499	ATP binding site [chemical binding]; other site
196162002500	Q-loop/lid; other site
196162002501	ABC transporter signature motif; other site
196162002502	Walker B; other site
196162002503	D-loop; other site
196162002504	H-loop/switch region; other site
196162002505	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162002506	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162002507	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
196162002508	Walker A/P-loop; other site
196162002509	ATP binding site [chemical binding]; other site
196162002510	Q-loop/lid; other site
196162002511	ABC transporter signature motif; other site
196162002512	Walker B; other site
196162002513	D-loop; other site
196162002514	H-loop/switch region; other site
196162002515	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
196162002516	FHIPEP family; Region: FHIPEP; pfam00771
196162002517	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
196162002518	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
196162002519	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
196162002520	FliP family; Region: FliP; pfam00813
196162002521	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
196162002522	flagellar motor switch protein FliN; Region: fliN; TIGR02480
196162002523	Flagellar motor switch protein FliM; Region: FliM; pfam02154
196162002524	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
196162002525	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
196162002526	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
196162002527	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
196162002528	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
196162002529	ligand binding site [chemical binding]; other site
196162002530	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
196162002531	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
196162002532	Flagellar protein (FlbD); Region: FlbD; pfam06289
196162002533	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
196162002534	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
196162002535	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
196162002536	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
196162002537	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
196162002538	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
196162002539	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196162002540	NlpC/P60 family; Region: NLPC_P60; pfam00877
196162002541	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
196162002542	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
196162002543	N-acetyl-D-glucosamine binding site [chemical binding]; other site
196162002544	catalytic residue [active]
196162002545	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
196162002546	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
196162002547	Walker A motif/ATP binding site; other site
196162002548	Walker B motif; other site
196162002549	Flagellar assembly protein FliH; Region: FliH; pfam02108
196162002550	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
196162002551	FliG C-terminal domain; Region: FliG_C; pfam01706
196162002552	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
196162002553	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
196162002554	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
196162002555	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
196162002556	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
196162002557	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
196162002558	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
196162002559	Flagellar protein FliS; Region: FliS; cl00654
196162002560	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
196162002561	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
196162002562	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
196162002563	flagellin; Reviewed; Region: PRK08869
196162002564	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
196162002565	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
196162002566	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
196162002567	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162002568	DNA binding residues [nucleotide binding]
196162002569	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
196162002570	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
196162002571	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
196162002572	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
196162002573	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
196162002574	FliW protein; Region: FliW; pfam02623
196162002575	Global regulator protein family; Region: CsrA; pfam02599
196162002576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162002577	putative substrate translocation pore; other site
196162002578	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162002579	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196162002580	MarR family; Region: MarR; pfam01047
196162002581	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
196162002582	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
196162002583	active site
196162002584	catalytic site [active]
196162002585	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
196162002586	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
196162002587	DNA photolyase; Region: DNA_photolyase; pfam00875
196162002588	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
196162002589	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
196162002590	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
196162002591	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
196162002592	FeoA domain; Region: FeoA; cl00838
196162002593	NAD-dependent deacetylase; Provisional; Region: PRK00481
196162002594	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
196162002595	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
196162002596	Uncharacterized conserved protein [Function unknown]; Region: COG3268
196162002597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162002598	NAD(P) binding site [chemical binding]; other site
196162002599	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
196162002600	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
196162002601	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
196162002602	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
196162002603	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
196162002604	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
196162002605	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
196162002606	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
196162002607	active site
196162002608	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
196162002609	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
196162002610	Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897
196162002611	active site
196162002612	substrate binding site; other site
196162002613	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
196162002614	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
196162002615	dimer interface [polypeptide binding]; other site
196162002616	putative functional site; other site
196162002617	putative MPT binding site; other site
196162002618	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
196162002619	trimer interface [polypeptide binding]; other site
196162002620	dimer interface [polypeptide binding]; other site
196162002621	putative active site [active]
196162002622	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
196162002623	MPT binding site; other site
196162002624	trimer interface [polypeptide binding]; other site
196162002625	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196162002626	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196162002627	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162002628	classical (c) SDRs; Region: SDR_c; cd05233
196162002629	NAD(P) binding site [chemical binding]; other site
196162002630	active site
196162002631	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
196162002632	FMN binding site [chemical binding]; other site
196162002633	dimer interface [polypeptide binding]; other site
196162002634	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
196162002635	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
196162002636	B12 binding site [chemical binding]; other site
196162002637	acyl-CoA synthetase; Validated; Region: PRK08316
196162002638	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162002639	acyl-activating enzyme (AAE) consensus motif; other site
196162002640	AMP binding site [chemical binding]; other site
196162002641	active site
196162002642	CoA binding site [chemical binding]; other site
196162002643	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162002644	enoyl-CoA hydratase; Provisional; Region: PRK05864
196162002645	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162002646	substrate binding site [chemical binding]; other site
196162002647	oxyanion hole (OAH) forming residues; other site
196162002648	trimer interface [polypeptide binding]; other site
196162002649	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162002650	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162002651	active site
196162002652	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162002653	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162002654	active site
196162002655	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
196162002656	FMN binding site [chemical binding]; other site
196162002657	dimer interface [polypeptide binding]; other site
196162002658	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162002659	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162002660	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162002661	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162002662	Walker A/P-loop; other site
196162002663	ATP binding site [chemical binding]; other site
196162002664	Q-loop/lid; other site
196162002665	ABC transporter signature motif; other site
196162002666	Walker B; other site
196162002667	D-loop; other site
196162002668	H-loop/switch region; other site
196162002669	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162002670	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162002671	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162002672	TM-ABC transporter signature motif; other site
196162002673	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162002674	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162002675	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
196162002676	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162002677	enoyl-CoA hydratase; Provisional; Region: PRK08252
196162002678	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162002679	substrate binding site [chemical binding]; other site
196162002680	oxyanion hole (OAH) forming residues; other site
196162002681	trimer interface [polypeptide binding]; other site
196162002682	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162002683	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162002684	F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564
196162002685	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162002686	FO synthase; Reviewed; Region: fbiC; PRK09234
196162002687	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162002688	FeS/SAM binding site; other site
196162002689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162002690	FeS/SAM binding site; other site
196162002691	Guanylyl transferase CofC like; Region: CofC; cl17472
196162002692	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
196162002693	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
196162002694	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162002695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162002696	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162002697	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162002698	active site
196162002699	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
196162002700	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
196162002701	Protein of unknown function (DUF1271); Region: DUF1271; pfam06902
196162002702	Uncharacterized conserved protein [Function unknown]; Region: COG2128
196162002703	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
196162002704	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
196162002705	[2Fe-2S] cluster binding site [ion binding]; other site
196162002706	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
196162002707	putative alpha subunit interface [polypeptide binding]; other site
196162002708	putative active site [active]
196162002709	putative substrate binding site [chemical binding]; other site
196162002710	Fe binding site [ion binding]; other site
196162002711	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
196162002712	inter-subunit interface; other site
196162002713	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
196162002714	catalytic triad [active]
196162002715	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
196162002716	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
196162002717	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
196162002718	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
196162002719	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162002720	catalytic loop [active]
196162002721	iron binding site [ion binding]; other site
196162002722	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
196162002723	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162002724	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162002725	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
196162002726	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
196162002727	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162002728	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
196162002729	dimerization interface [polypeptide binding]; other site
196162002730	substrate binding pocket [chemical binding]; other site
196162002731	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
196162002732	Muconate lactonizing enzyme (MLE) like subgroup of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and residues that can...; Region: MLE_like; cd03315
196162002733	active site
196162002734	catechol 1,2-dioxygenase, Actinobacterial; Region: catachol_actin; TIGR02438
196162002735	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
196162002736	active site
196162002737	muconolactone delta-isomerase; Region: muco_delta; TIGR03221
196162002738	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
196162002739	heme-binding site [chemical binding]; other site
196162002740	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
196162002741	metal binding site 2 [ion binding]; metal-binding site
196162002742	putative DNA binding helix; other site
196162002743	metal binding site 1 [ion binding]; metal-binding site
196162002744	dimer interface [polypeptide binding]; other site
196162002745	structural Zn2+ binding site [ion binding]; other site
196162002746	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162002747	MarR family; Region: MarR; pfam01047
196162002748	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162002749	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162002750	DNA-binding site [nucleotide binding]; DNA binding site
196162002751	FCD domain; Region: FCD; pfam07729
196162002752	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
196162002753	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162002754	thiolase; Provisional; Region: PRK06158
196162002755	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162002756	active site
196162002757	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
196162002758	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
196162002759	active site pocket [active]
196162002760	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162002761	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162002762	NAD(P) binding site [chemical binding]; other site
196162002763	catalytic residues [active]
196162002764	Cupin domain; Region: Cupin_2; pfam07883
196162002765	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162002766	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162002767	active site
196162002768	metal binding site [ion binding]; metal-binding site
196162002769	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162002770	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
196162002771	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162002772	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162002773	DNA-binding site [nucleotide binding]; DNA binding site
196162002774	FCD domain; Region: FCD; pfam07729
196162002775	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162002776	Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360
196162002777	putative ligand binding site [chemical binding]; other site
196162002778	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162002779	TM-ABC transporter signature motif; other site
196162002780	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162002781	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162002782	TM-ABC transporter signature motif; other site
196162002783	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162002784	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162002785	Walker A/P-loop; other site
196162002786	ATP binding site [chemical binding]; other site
196162002787	Q-loop/lid; other site
196162002788	ABC transporter signature motif; other site
196162002789	Walker B; other site
196162002790	D-loop; other site
196162002791	H-loop/switch region; other site
196162002792	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
196162002793	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162002794	Walker A/P-loop; other site
196162002795	ATP binding site [chemical binding]; other site
196162002796	Q-loop/lid; other site
196162002797	ABC transporter signature motif; other site
196162002798	Walker B; other site
196162002799	D-loop; other site
196162002800	H-loop/switch region; other site
196162002801	methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271
196162002802	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162002803	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162002804	substrate binding site [chemical binding]; other site
196162002805	oxyanion hole (OAH) forming residues; other site
196162002806	trimer interface [polypeptide binding]; other site
196162002807	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162002808	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162002809	active site
196162002810	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162002811	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162002812	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
196162002813	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
196162002814	active site
196162002815	acyl-activating enzyme (AAE) consensus motif; other site
196162002816	putative CoA binding site [chemical binding]; other site
196162002817	AMP binding site [chemical binding]; other site
196162002818	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260
196162002819	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162002820	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162002821	enoyl-CoA hydratase; Provisional; Region: PRK07827
196162002822	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162002823	substrate binding site [chemical binding]; other site
196162002824	oxyanion hole (OAH) forming residues; other site
196162002825	trimer interface [polypeptide binding]; other site
196162002826	FO synthase; Reviewed; Region: fbiC; PRK09234
196162002827	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162002828	FeS/SAM binding site; other site
196162002829	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162002830	FeS/SAM binding site; other site
196162002831	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
196162002832	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
196162002833	Guanylyl transferase CofC like; Region: CofC; cl17472
196162002834	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
196162002835	dimerization interface [polypeptide binding]; other site
196162002836	active site
196162002837	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
196162002838	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196162002839	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162002840	nucleotide binding site [chemical binding]; other site
196162002841	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196162002842	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
196162002843	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
196162002844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162002845	dimer interface [polypeptide binding]; other site
196162002846	conserved gate region; other site
196162002847	putative PBP binding loops; other site
196162002848	ABC-ATPase subunit interface; other site
196162002849	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162002850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162002851	dimer interface [polypeptide binding]; other site
196162002852	conserved gate region; other site
196162002853	putative PBP binding loops; other site
196162002854	ABC-ATPase subunit interface; other site
196162002855	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
196162002856	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
196162002857	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
196162002858	dimer interface [polypeptide binding]; other site
196162002859	active site
196162002860	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196162002861	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
196162002862	substrate binding site [chemical binding]; other site
196162002863	ATP binding site [chemical binding]; other site
196162002864	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
196162002865	metal binding site 2 [ion binding]; metal-binding site
196162002866	putative DNA binding helix; other site
196162002867	metal binding site 1 [ion binding]; metal-binding site
196162002868	dimer interface [polypeptide binding]; other site
196162002869	structural Zn2+ binding site [ion binding]; other site
196162002870	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
196162002871	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
196162002872	dimer interface [polypeptide binding]; other site
196162002873	active site
196162002874	heme binding site [chemical binding]; other site
196162002875	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
196162002876	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
196162002877	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
196162002878	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162002879	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162002880	active site
196162002881	catalytic tetrad [active]
196162002882	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162002883	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196162002884	Walker A/P-loop; other site
196162002885	ATP binding site [chemical binding]; other site
196162002886	Q-loop/lid; other site
196162002887	ABC transporter signature motif; other site
196162002888	Walker B; other site
196162002889	D-loop; other site
196162002890	H-loop/switch region; other site
196162002891	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162002892	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196162002893	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
196162002894	protein binding site [polypeptide binding]; other site
196162002895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162002896	H+ Antiporter protein; Region: 2A0121; TIGR00900
196162002897	putative substrate translocation pore; other site
196162002898	choice-of-anchor A domain; Region: choice_anch_A; TIGR04215
196162002899	Domain of unknown function DUF11; Region: DUF11; pfam01345
196162002900	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
196162002901	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
196162002902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162002903	motif II; other site
196162002904	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
196162002905	Citrate synthase; Region: Citrate_synt; pfam00285
196162002906	oxalacetate binding site [chemical binding]; other site
196162002907	citrylCoA binding site [chemical binding]; other site
196162002908	coenzyme A binding site [chemical binding]; other site
196162002909	catalytic triad [active]
196162002910	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
196162002911	23S rRNA interface [nucleotide binding]; other site
196162002912	L3 interface [polypeptide binding]; other site
196162002913	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
196162002914	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
196162002915	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
196162002916	active site
196162002917	substrate binding site [chemical binding]; other site
196162002918	metal binding site [ion binding]; metal-binding site
196162002919	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162002920	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
196162002921	Walker A/P-loop; other site
196162002922	ATP binding site [chemical binding]; other site
196162002923	Q-loop/lid; other site
196162002924	ABC transporter signature motif; other site
196162002925	Walker B; other site
196162002926	D-loop; other site
196162002927	H-loop/switch region; other site
196162002928	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
196162002929	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
196162002930	pantothenate kinase; Provisional; Region: PRK05439
196162002931	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
196162002932	ATP-binding site [chemical binding]; other site
196162002933	CoA-binding site [chemical binding]; other site
196162002934	Mg2+-binding site [ion binding]; other site
196162002935	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
196162002936	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
196162002937	glutaminase active site [active]
196162002938	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
196162002939	dimer interface [polypeptide binding]; other site
196162002940	active site
196162002941	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
196162002942	dimer interface [polypeptide binding]; other site
196162002943	active site
196162002944	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
196162002945	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
196162002946	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
196162002947	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
196162002948	putative substrate binding site [chemical binding]; other site
196162002949	putative ATP binding site [chemical binding]; other site
196162002950	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
196162002951	alanine racemase; Reviewed; Region: alr; PRK00053
196162002952	active site
196162002953	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162002954	dimer interface [polypeptide binding]; other site
196162002955	substrate binding site [chemical binding]; other site
196162002956	catalytic residues [active]
196162002957	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162002958	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
196162002959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
196162002960	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
196162002961	putative ADP-binding pocket [chemical binding]; other site
196162002962	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162002963	Protein of unknown function (DUF3184); Region: DUF3184; pfam11380
196162002964	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
196162002965	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
196162002966	active site
196162002967	DNA binding site [nucleotide binding]
196162002968	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
196162002969	DNA binding site [nucleotide binding]
196162002970	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
196162002971	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
196162002972	Substrate binding site; other site
196162002973	Mg++ binding site; other site
196162002974	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
196162002975	active site
196162002976	substrate binding site [chemical binding]; other site
196162002977	CoA binding site [chemical binding]; other site
196162002978	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
196162002979	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
196162002980	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162002981	active site
196162002982	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
196162002983	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
196162002984	Zn binding site [ion binding]; other site
196162002985	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
196162002986	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
196162002987	5S rRNA interface [nucleotide binding]; other site
196162002988	CTC domain interface [polypeptide binding]; other site
196162002989	L16 interface [polypeptide binding]; other site
196162002990	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
196162002991	putative active site [active]
196162002992	catalytic residue [active]
196162002993	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
196162002994	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196162002995	active site
196162002996	active site
196162002997	metal binding site [ion binding]; metal-binding site
196162002998	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
196162002999	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
196162003000	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162003001	dimer interface [polypeptide binding]; other site
196162003002	conserved gate region; other site
196162003003	putative PBP binding loops; other site
196162003004	ABC-ATPase subunit interface; other site
196162003005	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
196162003006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162003007	dimer interface [polypeptide binding]; other site
196162003008	conserved gate region; other site
196162003009	putative PBP binding loops; other site
196162003010	ABC-ATPase subunit interface; other site
196162003011	PBP superfamily domain; Region: PBP_like_2; cl17296
196162003012	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
196162003013	active site
196162003014	PBP superfamily domain; Region: PBP_like_2; cl17296
196162003015	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
196162003016	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
196162003017	Walker A/P-loop; other site
196162003018	ATP binding site [chemical binding]; other site
196162003019	Q-loop/lid; other site
196162003020	ABC transporter signature motif; other site
196162003021	Walker B; other site
196162003022	D-loop; other site
196162003023	H-loop/switch region; other site
196162003024	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
196162003025	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
196162003026	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
196162003027	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
196162003028	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
196162003029	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162003030	ATP binding site [chemical binding]; other site
196162003031	putative Mg++ binding site [ion binding]; other site
196162003032	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162003033	nucleotide binding region [chemical binding]; other site
196162003034	ATP-binding site [chemical binding]; other site
196162003035	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
196162003036	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333
196162003037	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
196162003038	homodimer interface [polypeptide binding]; other site
196162003039	metal binding site [ion binding]; metal-binding site
196162003040	enolase; Provisional; Region: eno; PRK00077
196162003041	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
196162003042	dimer interface [polypeptide binding]; other site
196162003043	metal binding site [ion binding]; metal-binding site
196162003044	substrate binding pocket [chemical binding]; other site
196162003045	Septum formation initiator; Region: DivIC; pfam04977
196162003046	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
196162003047	Protein of unknown function (DUF501); Region: DUF501; pfam04417
196162003048	exopolyphosphatase; Region: exo_poly_only; TIGR03706
196162003049	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
196162003050	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
196162003051	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
196162003052	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
196162003053	Fe-S cluster binding site [ion binding]; other site
196162003054	DNA binding site [nucleotide binding]
196162003055	active site
196162003056	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162003057	S-adenosylmethionine binding site [chemical binding]; other site
196162003058	Bax inhibitor 1 like; Region: BaxI_1; cl17691
196162003059	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
196162003060	active site
196162003061	catalytic triad [active]
196162003062	oxyanion hole [active]
196162003063	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
196162003064	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
196162003065	dimer interface [polypeptide binding]; other site
196162003066	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162003067	catalytic residue [active]
196162003068	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
196162003069	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
196162003070	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162003071	lipid-transfer protein; Provisional; Region: PRK06059
196162003072	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162003073	active site
196162003074	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
196162003075	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
196162003076	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
196162003077	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
196162003078	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
196162003079	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
196162003080	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162003081	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
196162003082	Walker A/P-loop; other site
196162003083	ATP binding site [chemical binding]; other site
196162003084	Q-loop/lid; other site
196162003085	ABC transporter signature motif; other site
196162003086	Walker B; other site
196162003087	D-loop; other site
196162003088	H-loop/switch region; other site
196162003089	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
196162003090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003091	Walker A/P-loop; other site
196162003092	ATP binding site [chemical binding]; other site
196162003093	Q-loop/lid; other site
196162003094	ABC transporter signature motif; other site
196162003095	Walker B; other site
196162003096	D-loop; other site
196162003097	H-loop/switch region; other site
196162003098	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162003099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003100	active site
196162003101	phosphorylation site [posttranslational modification]
196162003102	intermolecular recognition site; other site
196162003103	dimerization interface [polypeptide binding]; other site
196162003104	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162003105	DNA binding residues [nucleotide binding]
196162003106	dimerization interface [polypeptide binding]; other site
196162003107	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
196162003108	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
196162003109	Histidine kinase; Region: HisKA_3; pfam07730
196162003110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162003111	ATP binding site [chemical binding]; other site
196162003112	Mg2+ binding site [ion binding]; other site
196162003113	G-X-G motif; other site
196162003114	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
196162003115	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003116	Ligand Binding Site [chemical binding]; other site
196162003117	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003118	Ligand Binding Site [chemical binding]; other site
196162003119	CBS domain; Region: CBS; pfam00571
196162003120	hypothetical protein; Provisional; Region: PRK04233
196162003121	SEC-C motif; Region: SEC-C; pfam02810
196162003122	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
196162003123	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
196162003124	Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867
196162003125	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
196162003126	metal ion-dependent adhesion site (MIDAS); other site
196162003127	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
196162003128	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
196162003129	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
196162003130	putative active site [active]
196162003131	putative catalytic site [active]
196162003132	Protein of unknown function (DUF2695); Region: DUF2695; pfam10905
196162003133	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196162003134	intersubunit interface [polypeptide binding]; other site
196162003135	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
196162003136	hypothetical protein; Provisional; Region: PRK10621
196162003137	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196162003138	Uncharacterized conserved protein [Function unknown]; Region: COG1739
196162003139	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
196162003140	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
196162003141	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
196162003142	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162003143	active site
196162003144	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162003145	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162003146	active site
196162003147	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
196162003148	ABC1 family; Region: ABC1; cl17513
196162003149	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
196162003150	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162003151	PspC domain; Region: PspC; pfam04024
196162003152	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196162003153	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162003154	Walker A/P-loop; other site
196162003155	ATP binding site [chemical binding]; other site
196162003156	Q-loop/lid; other site
196162003157	ABC transporter signature motif; other site
196162003158	Walker B; other site
196162003159	D-loop; other site
196162003160	H-loop/switch region; other site
196162003161	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196162003162	FtsX-like permease family; Region: FtsX; pfam02687
196162003163	YCII-related domain; Region: YCII; cl00999
196162003164	Secretory lipase; Region: LIP; pfam03583
196162003165	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162003166	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162003167	methionine sulfoxide reductase A; Provisional; Region: PRK00058
196162003168	cystathionine gamma-synthase; Provisional; Region: PRK07811
196162003169	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
196162003170	homodimer interface [polypeptide binding]; other site
196162003171	substrate-cofactor binding pocket; other site
196162003172	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162003173	catalytic residue [active]
196162003174	MutL protein; Region: MutL; pfam13941
196162003175	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
196162003176	threonine dehydratase; Provisional; Region: PRK08198
196162003177	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
196162003178	tetramer interface [polypeptide binding]; other site
196162003179	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162003180	catalytic residue [active]
196162003181	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
196162003182	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
196162003183	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
196162003184	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
196162003185	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
196162003186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162003187	S-adenosylmethionine binding site [chemical binding]; other site
196162003188	pyruvate phosphate dikinase; Provisional; Region: PRK09279
196162003189	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
196162003190	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
196162003191	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
196162003192	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003193	Ligand Binding Site [chemical binding]; other site
196162003194	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003195	Ligand Binding Site [chemical binding]; other site
196162003196	Universal stress protein family; Region: Usp; pfam00582
196162003197	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
196162003198	FMN binding site [chemical binding]; other site
196162003199	dimer interface [polypeptide binding]; other site
196162003200	FOG: CBS domain [General function prediction only]; Region: COG0517
196162003201	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
196162003202	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162003203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003204	active site
196162003205	phosphorylation site [posttranslational modification]
196162003206	intermolecular recognition site; other site
196162003207	dimerization interface [polypeptide binding]; other site
196162003208	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162003209	DNA binding residues [nucleotide binding]
196162003210	dimerization interface [polypeptide binding]; other site
196162003211	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
196162003212	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
196162003213	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
196162003214	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
196162003215	GAF domain; Region: GAF_3; pfam13492
196162003216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162003217	Histidine kinase; Region: HisKA_3; pfam07730
196162003218	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162003219	ATP binding site [chemical binding]; other site
196162003220	Mg2+ binding site [ion binding]; other site
196162003221	G-X-G motif; other site
196162003222	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
196162003223	Universal stress protein family; Region: Usp; pfam00582
196162003224	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003225	Ligand Binding Site [chemical binding]; other site
196162003226	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003227	Ligand Binding Site [chemical binding]; other site
196162003228	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003229	Ligand Binding Site [chemical binding]; other site
196162003230	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162003231	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
196162003232	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
196162003233	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162003234	active site
196162003235	motif I; other site
196162003236	motif II; other site
196162003237	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
196162003238	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
196162003239	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003240	Ligand Binding Site [chemical binding]; other site
196162003241	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003242	Ligand Binding Site [chemical binding]; other site
196162003243	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
196162003244	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162003245	Beta-Casp domain; Region: Beta-Casp; smart01027
196162003246	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
196162003247	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
196162003248	Fructose-1,6-bisphosphate aldolase; Region: FBP_aldolase_I_a; cd00948
196162003249	active site
196162003250	intersubunit interface [polypeptide binding]; other site
196162003251	catalytic residue [active]
196162003252	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
196162003253	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
196162003254	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162003255	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
196162003256	CoA binding domain; Region: CoA_binding_2; pfam13380
196162003257	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
196162003258	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
196162003259	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003260	Ligand Binding Site [chemical binding]; other site
196162003261	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162003262	Ligand Binding Site [chemical binding]; other site
196162003263	PAS fold; Region: PAS_4; pfam08448
196162003264	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003265	putative active site [active]
196162003266	heme pocket [chemical binding]; other site
196162003267	Phosphoesterase family; Region: Phosphoesterase; pfam04185
196162003268	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162003269	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
196162003270	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
196162003271	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
196162003272	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162003273	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
196162003274	dimerization interface [polypeptide binding]; other site
196162003275	substrate binding pocket [chemical binding]; other site
196162003276	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
196162003277	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162003278	dimer interface [polypeptide binding]; other site
196162003279	active site
196162003280	Coenzyme A transferase; Region: CoA_trans; cl17247
196162003281	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
196162003282	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162003283	active site
196162003284	HIGH motif; other site
196162003285	nucleotide binding site [chemical binding]; other site
196162003286	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162003287	active site
196162003288	KMSKS motif; other site
196162003289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162003290	Histidine kinase; Region: HisKA_3; pfam07730
196162003291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162003292	ATP binding site [chemical binding]; other site
196162003293	Mg2+ binding site [ion binding]; other site
196162003294	G-X-G motif; other site
196162003295	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162003296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003297	active site
196162003298	phosphorylation site [posttranslational modification]
196162003299	intermolecular recognition site; other site
196162003300	dimerization interface [polypeptide binding]; other site
196162003301	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162003302	DNA binding residues [nucleotide binding]
196162003303	dimerization interface [polypeptide binding]; other site
196162003304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003305	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
196162003306	Walker A/P-loop; other site
196162003307	ATP binding site [chemical binding]; other site
196162003308	Q-loop/lid; other site
196162003309	ABC transporter signature motif; other site
196162003310	Walker B; other site
196162003311	D-loop; other site
196162003312	H-loop/switch region; other site
196162003313	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
196162003314	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
196162003315	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
196162003316	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162003317	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162003318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
196162003319	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162003320	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162003321	Coenzyme A binding pocket [chemical binding]; other site
196162003322	LabA_like proteins; Region: LabA_like; cd06167
196162003323	putative metal binding site [ion binding]; other site
196162003324	Domain of unknown function DUF87; Region: DUF87; pfam01935
196162003325	AAA-like domain; Region: AAA_10; pfam12846
196162003326	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
196162003327	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162003328	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162003329	catalytic residue [active]
196162003330	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162003331	Walker A motif; other site
196162003332	ATP binding site [chemical binding]; other site
196162003333	arginine finger; other site
196162003334	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196162003335	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
196162003336	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
196162003337	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162003338	FeS/SAM binding site; other site
196162003339	Nitroreductase family; Region: Nitroreductase; pfam00881
196162003340	FMN binding site [chemical binding]; other site
196162003341	dimer interface [polypeptide binding]; other site
196162003342	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
196162003343	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162003344	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162003345	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162003346	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
196162003347	substrate binding pocket [chemical binding]; other site
196162003348	active site
196162003349	iron coordination sites [ion binding]; other site
196162003350	Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132
196162003351	PLD-like domain; Region: PLDc_2; pfam13091
196162003352	putative active site [active]
196162003353	putative catalytic site [active]
196162003354	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
196162003355	MarR family; Region: MarR_2; pfam12802
196162003356	Nuclease-related domain; Region: NERD; pfam08378
196162003357	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162003358	active site
196162003359	catalytic residues [active]
196162003360	DNA binding site [nucleotide binding]
196162003361	Int/Topo IB signature motif; other site
196162003362	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
196162003363	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
196162003364	catalytic residues [active]
196162003365	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162003366	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
196162003367	NAD(P) binding site [chemical binding]; other site
196162003368	catalytic residues [active]
196162003369	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
196162003370	catalytic site [active]
196162003371	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162003372	putative hydrolase; Provisional; Region: PRK11460
196162003373	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
196162003374	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
196162003375	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
196162003376	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
196162003377	catalytic residue [active]
196162003378	putative FPP diphosphate  binding site; other site
196162003379	putative FPP binding hydrophobic cleft; other site
196162003380	dimer interface [polypeptide binding]; other site
196162003381	putative IPP diphosphate binding site; other site
196162003382	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
196162003383	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
196162003384	putative active site [active]
196162003385	PhoH-like protein; Region: PhoH; pfam02562
196162003386	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
196162003387	N-acetyl-D-glucosamine binding site [chemical binding]; other site
196162003388	catalytic residue [active]
196162003389	fumarate hydratase; Reviewed; Region: fumC; PRK00485
196162003390	aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596
196162003391	active sites [active]
196162003392	tetramer interface [polypeptide binding]; other site
196162003393	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196162003394	fumarate hydratase; Provisional; Region: PRK15389
196162003395	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
196162003396	Fumarase C-terminus; Region: Fumerase_C; pfam05683
196162003397	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196162003398	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
196162003399	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
196162003400	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
196162003401	Walker A/P-loop; other site
196162003402	ATP binding site [chemical binding]; other site
196162003403	Q-loop/lid; other site
196162003404	ABC transporter signature motif; other site
196162003405	Walker B; other site
196162003406	D-loop; other site
196162003407	H-loop/switch region; other site
196162003408	TOBE domain; Region: TOBE_2; pfam08402
196162003409	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162003410	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162003411	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
196162003412	PGAP1-like protein; Region: PGAP1; pfam07819
196162003413	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
196162003414	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
196162003415	putative active site [active]
196162003416	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
196162003417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003418	Walker A/P-loop; other site
196162003419	ATP binding site [chemical binding]; other site
196162003420	Q-loop/lid; other site
196162003421	TOBE domain; Region: TOBE; pfam03459
196162003422	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
196162003423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162003424	dimer interface [polypeptide binding]; other site
196162003425	conserved gate region; other site
196162003426	putative PBP binding loops; other site
196162003427	ABC-ATPase subunit interface; other site
196162003428	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
196162003429	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162003430	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
196162003431	DNA binding residues [nucleotide binding]
196162003432	TOBE domain; Region: TOBE; cl01440
196162003433	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
196162003434	conserved repeat domain; Region: B_ant_repeat; TIGR01451
196162003435	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
196162003436	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
196162003437	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
196162003438	generic binding surface II; other site
196162003439	generic binding surface I; other site
196162003440	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700
196162003441	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
196162003442	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
196162003443	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
196162003444	RmuC family; Region: RmuC; pfam02646
196162003445	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
196162003446	putative catalytic site [active]
196162003447	putative phosphate binding site [ion binding]; other site
196162003448	active site
196162003449	metal binding site A [ion binding]; metal-binding site
196162003450	DNA binding site [nucleotide binding]
196162003451	putative AP binding site [nucleotide binding]; other site
196162003452	putative metal binding site B [ion binding]; other site
196162003453	GTP-binding protein YchF; Reviewed; Region: PRK09601
196162003454	YchF GTPase; Region: YchF; cd01900
196162003455	G1 box; other site
196162003456	GTP/Mg2+ binding site [chemical binding]; other site
196162003457	Switch I region; other site
196162003458	G2 box; other site
196162003459	Switch II region; other site
196162003460	G3 box; other site
196162003461	G4 box; other site
196162003462	G5 box; other site
196162003463	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
196162003464	Restriction endonuclease; Region: Mrr_cat; pfam04471
196162003465	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
196162003466	DNA methylase; Region: N6_N4_Mtase; pfam01555
196162003467	DNA methylase; Region: N6_N4_Mtase; pfam01555
196162003468	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196162003469	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
196162003470	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
196162003471	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
196162003472	catalytic residues [active]
196162003473	catalytic nucleophile [active]
196162003474	Recombinase; Region: Recombinase; pfam07508
196162003475	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
196162003476	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
196162003477	catalytic residues [active]
196162003478	catalytic nucleophile [active]
196162003479	Recombinase; Region: Recombinase; pfam07508
196162003480	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
196162003481	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
196162003482	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
196162003483	active site
196162003484	NTP binding site [chemical binding]; other site
196162003485	metal binding triad [ion binding]; metal-binding site
196162003486	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
196162003487	Ligand Binding Site [chemical binding]; other site
196162003488	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
196162003489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162003490	FeS/SAM binding site; other site
196162003491	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
196162003492	active site
196162003493	integrase; Provisional; Region: int; PHA02601
196162003494	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162003495	active site
196162003496	DNA binding site [nucleotide binding]
196162003497	Int/Topo IB signature motif; other site
196162003498	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162003499	non-specific DNA binding site [nucleotide binding]; other site
196162003500	salt bridge; other site
196162003501	sequence-specific DNA binding site [nucleotide binding]; other site
196162003502	TrwC relaxase; Region: TrwC; pfam08751
196162003503	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
196162003504	AAA domain; Region: AAA_30; pfam13604
196162003505	Protein of unknown function DUF262; Region: DUF262; pfam03235
196162003506	Uncharacterized conserved protein [Function unknown]; Region: COG1479
196162003507	Protein of unknown function DUF262; Region: DUF262; pfam03235
196162003508	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
196162003509	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
196162003510	HsdM N-terminal domain; Region: HsdM_N; pfam12161
196162003511	Methyltransferase domain; Region: Methyltransf_26; pfam13659
196162003512	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
196162003513	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
196162003514	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
196162003515	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
196162003516	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
196162003517	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
196162003518	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162003519	ATP binding site [chemical binding]; other site
196162003520	putative Mg++ binding site [ion binding]; other site
196162003521	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
196162003522	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162003523	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
196162003524	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162003525	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
196162003526	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
196162003527	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162003528	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162003529	NAD(P) binding site [chemical binding]; other site
196162003530	catalytic residues [active]
196162003531	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162003532	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196162003533	tetramerization interface [polypeptide binding]; other site
196162003534	NAD(P) binding site [chemical binding]; other site
196162003535	catalytic residues [active]
196162003536	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162003537	dimer interface [polypeptide binding]; other site
196162003538	phosphorylation site [posttranslational modification]
196162003539	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162003540	ATP binding site [chemical binding]; other site
196162003541	Mg2+ binding site [ion binding]; other site
196162003542	G-X-G motif; other site
196162003543	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
196162003544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003545	active site
196162003546	phosphorylation site [posttranslational modification]
196162003547	intermolecular recognition site; other site
196162003548	dimerization interface [polypeptide binding]; other site
196162003549	Response regulator receiver domain; Region: Response_reg; pfam00072
196162003550	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003551	active site
196162003552	phosphorylation site [posttranslational modification]
196162003553	intermolecular recognition site; other site
196162003554	dimerization interface [polypeptide binding]; other site
196162003555	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
196162003556	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162003557	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162003558	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162003559	DNA binding residues [nucleotide binding]
196162003560	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162003561	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162003562	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
196162003563	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
196162003564	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
196162003565	Type II transport protein GspH; Region: GspH; pfam12019
196162003566	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
196162003567	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
196162003568	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
196162003569	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
196162003570	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
196162003571	Walker A motif; other site
196162003572	ATP binding site [chemical binding]; other site
196162003573	Walker B motif; other site
196162003574	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
196162003575	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196162003576	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196162003577	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
196162003578	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
196162003579	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
196162003580	Walker A motif; other site
196162003581	ATP binding site [chemical binding]; other site
196162003582	Walker B motif; other site
196162003583	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
196162003584	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
196162003585	Walker A motif; other site
196162003586	ATP binding site [chemical binding]; other site
196162003587	Walker B motif; other site
196162003588	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
196162003589	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
196162003590	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
196162003591	PAS domain; Region: PAS_9; pfam13426
196162003592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003593	putative active site [active]
196162003594	heme pocket [chemical binding]; other site
196162003595	PAS domain; Region: PAS; smart00091
196162003596	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
196162003597	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003598	putative active site [active]
196162003599	heme pocket [chemical binding]; other site
196162003600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003601	putative active site [active]
196162003602	heme pocket [chemical binding]; other site
196162003603	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
196162003604	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
196162003605	metal binding site [ion binding]; metal-binding site
196162003606	active site
196162003607	I-site; other site
196162003608	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003609	PAS domain; Region: PAS_9; pfam13426
196162003610	putative active site [active]
196162003611	heme pocket [chemical binding]; other site
196162003612	PAS domain S-box; Region: sensory_box; TIGR00229
196162003613	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003614	putative active site [active]
196162003615	heme pocket [chemical binding]; other site
196162003616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003617	PAS domain; Region: PAS_9; pfam13426
196162003618	putative active site [active]
196162003619	heme pocket [chemical binding]; other site
196162003620	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
196162003621	metal binding site [ion binding]; metal-binding site
196162003622	active site
196162003623	I-site; other site
196162003624	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
196162003625	PAS domain S-box; Region: sensory_box; TIGR00229
196162003626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003627	putative active site [active]
196162003628	heme pocket [chemical binding]; other site
196162003629	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
196162003630	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
196162003631	metal binding site [ion binding]; metal-binding site
196162003632	active site
196162003633	I-site; other site
196162003634	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
196162003635	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196162003636	FAD binding domain; Region: FAD_binding_2; pfam00890
196162003637	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
196162003638	nucleoside/Zn binding site; other site
196162003639	dimer interface [polypeptide binding]; other site
196162003640	catalytic motif [active]
196162003641	urate oxidase; Region: urate_oxi; TIGR03383
196162003642	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
196162003643	active site
196162003644	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
196162003645	active site
196162003646	homotetramer interface [polypeptide binding]; other site
196162003647	OHCU decarboxylase; Region: UraD_2; TIGR03180
196162003648	Domain of unknown function (DUF202); Region: DUF202; cl09954
196162003649	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196162003650	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196162003651	active site
196162003652	metal binding site [ion binding]; metal-binding site
196162003653	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
196162003654	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162003655	active site 1 [active]
196162003656	active site 2 [active]
196162003657	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
196162003658	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
196162003659	PemK-like protein; Region: PemK; pfam02452
196162003660	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
196162003661	active site
196162003662	8-oxo-dGMP binding site [chemical binding]; other site
196162003663	nudix motif; other site
196162003664	metal binding site [ion binding]; metal-binding site
196162003665	AAA domain; Region: AAA_14; pfam13173
196162003666	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
196162003667	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
196162003668	Protein of unknown function (DUF433); Region: DUF433; pfam04255
196162003669	VanW like protein; Region: VanW; pfam04294
196162003670	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
196162003671	Lipase (class 2); Region: Lipase_2; pfam01674
196162003672	Glycerate kinase family; Region: Gly_kinase; cl00841
196162003673	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
196162003674	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
196162003675	trimer interface [polypeptide binding]; other site
196162003676	putative metal binding site [ion binding]; other site
196162003677	Putative cyclase; Region: Cyclase; pfam04199
196162003678	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162003679	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162003680	NAD(P) binding site [chemical binding]; other site
196162003681	FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941
196162003682	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162003683	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162003684	catalytic loop [active]
196162003685	iron binding site [ion binding]; other site
196162003686	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162003687	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162003688	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162003689	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162003690	hypothetical protein; Provisional; Region: PRK02399
196162003691	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
196162003692	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
196162003693	Transcriptional regulators [Transcription]; Region: GntR; COG1802
196162003694	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162003695	DNA-binding site [nucleotide binding]; DNA binding site
196162003696	FCD domain; Region: FCD; pfam07729
196162003697	Transcriptional regulators [Transcription]; Region: GntR; COG1802
196162003698	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162003699	DNA-binding site [nucleotide binding]; DNA binding site
196162003700	FCD domain; Region: FCD; pfam07729
196162003701	Transaldolase; Region: Transaldolase; pfam00923
196162003702	catalytic residue [active]
196162003703	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
196162003704	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
196162003705	catalytic Zn binding site [ion binding]; other site
196162003706	NAD binding site [chemical binding]; other site
196162003707	structural Zn binding site [ion binding]; other site
196162003708	short chain dehydrogenase; Provisional; Region: PRK07814
196162003709	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162003710	NAD(P) binding site [chemical binding]; other site
196162003711	active site
196162003712	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162003713	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162003714	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162003715	TM-ABC transporter signature motif; other site
196162003716	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162003717	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162003718	TM-ABC transporter signature motif; other site
196162003719	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162003720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003721	Walker A/P-loop; other site
196162003722	ATP binding site [chemical binding]; other site
196162003723	Q-loop/lid; other site
196162003724	ABC transporter signature motif; other site
196162003725	Walker B; other site
196162003726	D-loop; other site
196162003727	H-loop/switch region; other site
196162003728	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162003729	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162003730	Walker A/P-loop; other site
196162003731	ATP binding site [chemical binding]; other site
196162003732	Q-loop/lid; other site
196162003733	ABC transporter signature motif; other site
196162003734	Walker B; other site
196162003735	D-loop; other site
196162003736	H-loop/switch region; other site
196162003737	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
196162003738	ligand binding site [chemical binding]; other site
196162003739	hypothetical protein; Provisional; Region: PRK08296
196162003740	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
196162003741	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
196162003742	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
196162003743	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196162003744	Uncharacterized conserved protein [Function unknown]; Region: COG1359
196162003745	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
196162003746	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
196162003747	NAD(P) binding site [chemical binding]; other site
196162003748	catalytic residues [active]
196162003749	aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159
196162003750	Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop.  Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cd04100
196162003751	Dimer interface [polypeptide binding]; other site
196162003752	anticodon binding site; other site
196162003753	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196162003754	motif 1; other site
196162003755	dimer interface [polypeptide binding]; other site
196162003756	active site
196162003757	motif 2; other site
196162003758	motif 3; other site
196162003759	Domain of unknown function (DUF389); Region: DUF389; cl00781
196162003760	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162003761	Ferredoxin [Energy production and conversion]; Region: COG1146
196162003762	4Fe-4S binding domain; Region: Fer4; pfam00037
196162003763	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
196162003764	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162003765	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162003766	homodimer interface [polypeptide binding]; other site
196162003767	catalytic residue [active]
196162003768	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
196162003769	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
196162003770	putative trimer interface [polypeptide binding]; other site
196162003771	putative CoA binding site [chemical binding]; other site
196162003772	Protein of unknown function (DUF664); Region: DUF664; pfam04978
196162003773	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
196162003774	putative active site [active]
196162003775	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
196162003776	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
196162003777	HIGH motif; other site
196162003778	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
196162003779	active site
196162003780	KMSKS motif; other site
196162003781	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
196162003782	tRNA binding surface [nucleotide binding]; other site
196162003783	anticodon binding site; other site
196162003784	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
196162003785	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162003786	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
196162003787	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
196162003788	metal binding site [ion binding]; metal-binding site
196162003789	putative dimer interface [polypeptide binding]; other site
196162003790	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
196162003791	DivIVA domain; Region: DivI1A_domain; TIGR03544
196162003792	Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904
196162003793	putative active site [active]
196162003794	Zn binding site [ion binding]; other site
196162003795	enoyl-CoA hydratase; Provisional; Region: PRK06688
196162003796	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162003797	substrate binding site [chemical binding]; other site
196162003798	oxyanion hole (OAH) forming residues; other site
196162003799	trimer interface [polypeptide binding]; other site
196162003800	PaaX-like protein; Region: PaaX; pfam07848
196162003801	phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277
196162003802	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
196162003803	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
196162003804	multifunctional aminopeptidase A; Provisional; Region: PRK00913
196162003805	interface (dimer of trimers) [polypeptide binding]; other site
196162003806	Substrate-binding/catalytic site; other site
196162003807	Zn-binding sites [ion binding]; other site
196162003808	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
196162003809	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162003810	S-adenosylmethionine binding site [chemical binding]; other site
196162003811	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
196162003812	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162003813	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162003814	DNA binding residues [nucleotide binding]
196162003815	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
196162003816	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196162003817	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
196162003818	protein binding site [polypeptide binding]; other site
196162003819	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162003820	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
196162003821	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
196162003822	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
196162003823	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162003824	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
196162003825	NAD(P) binding site [chemical binding]; other site
196162003826	catalytic residues [active]
196162003827	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
196162003828	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
196162003829	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
196162003830	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
196162003831	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162003832	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162003833	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003834	Walker A/P-loop; other site
196162003835	ATP binding site [chemical binding]; other site
196162003836	Q-loop/lid; other site
196162003837	ABC transporter signature motif; other site
196162003838	Walker B; other site
196162003839	D-loop; other site
196162003840	H-loop/switch region; other site
196162003841	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162003842	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162003843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003844	Walker A/P-loop; other site
196162003845	ATP binding site [chemical binding]; other site
196162003846	Q-loop/lid; other site
196162003847	ABC transporter signature motif; other site
196162003848	Walker B; other site
196162003849	D-loop; other site
196162003850	H-loop/switch region; other site
196162003851	amidase; Provisional; Region: PRK12470
196162003852	Amidase; Region: Amidase; cl11426
196162003853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003854	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196162003855	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162003856	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
196162003857	classical (c) SDRs; Region: SDR_c; cd05233
196162003858	NAD(P) binding site [chemical binding]; other site
196162003859	active site
196162003860	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
196162003861	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162003862	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
196162003863	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
196162003864	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
196162003865	putative DNA binding site [nucleotide binding]; other site
196162003866	putative homodimer interface [polypeptide binding]; other site
196162003867	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
196162003868	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
196162003869	active site
196162003870	DNA binding site [nucleotide binding]
196162003871	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
196162003872	DNA binding site [nucleotide binding]
196162003873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
196162003874	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
196162003875	nucleotide binding site [chemical binding]; other site
196162003876	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
196162003877	Catalytic site [active]
196162003878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162003879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003880	active site
196162003881	phosphorylation site [posttranslational modification]
196162003882	intermolecular recognition site; other site
196162003883	dimerization interface [polypeptide binding]; other site
196162003884	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162003885	DNA binding site [nucleotide binding]
196162003886	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
196162003887	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162003888	active site
196162003889	motif I; other site
196162003890	motif II; other site
196162003891	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162003892	ydaO/yuaA element as predicted by Rfam (RF00379), score 63.91
196162003893	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196162003894	NlpC/P60 family; Region: NLPC_P60; cl17555
196162003895	oxaloacetate decarboxylase; Provisional; Region: PRK12330
196162003896	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
196162003897	active site
196162003898	catalytic residues [active]
196162003899	metal binding site [ion binding]; metal-binding site
196162003900	homodimer binding site [polypeptide binding]; other site
196162003901	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
196162003902	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196162003903	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196162003904	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162003905	carboxyltransferase (CT) interaction site; other site
196162003906	biotinylation site [posttranslational modification]; other site
196162003907	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
196162003908	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
196162003909	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196162003910	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
196162003911	ATP binding site [chemical binding]; other site
196162003912	Walker A motif; other site
196162003913	hexamer interface [polypeptide binding]; other site
196162003914	Walker B motif; other site
196162003915	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
196162003916	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
196162003917	PQQ-like domain; Region: PQQ_2; pfam13360
196162003918	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
196162003919	cheY-homologous receiver domain; Region: REC; smart00448
196162003920	Response regulator receiver domain; Region: Response_reg; pfam00072
196162003921	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003922	active site
196162003923	phosphorylation site [posttranslational modification]
196162003924	intermolecular recognition site; other site
196162003925	dimerization interface [polypeptide binding]; other site
196162003926	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162003927	PAS domain; Region: PAS_9; pfam13426
196162003928	putative active site [active]
196162003929	heme pocket [chemical binding]; other site
196162003930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162003931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162003932	ATP binding site [chemical binding]; other site
196162003933	Mg2+ binding site [ion binding]; other site
196162003934	G-X-G motif; other site
196162003935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162003936	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162003937	active site
196162003938	phosphorylation site [posttranslational modification]
196162003939	intermolecular recognition site; other site
196162003940	dimerization interface [polypeptide binding]; other site
196162003941	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
196162003942	peptide chain release factor 2; Validated; Region: prfB; PRK00578
196162003943	This domain is found in peptide chain release factors; Region: PCRF; smart00937
196162003944	RF-1 domain; Region: RF-1; pfam00472
196162003945	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
196162003946	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
196162003947	trehalose synthase; Region: treS_nterm; TIGR02456
196162003948	active site
196162003949	catalytic site [active]
196162003950	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
196162003951	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162003952	Walker A/P-loop; other site
196162003953	ATP binding site [chemical binding]; other site
196162003954	Q-loop/lid; other site
196162003955	ABC transporter signature motif; other site
196162003956	Walker B; other site
196162003957	D-loop; other site
196162003958	H-loop/switch region; other site
196162003959	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
196162003960	FtsX-like permease family; Region: FtsX; pfam02687
196162003961	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162003962	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162003963	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
196162003964	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
196162003965	active site
196162003966	substrate binding sites [chemical binding]; other site
196162003967	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
196162003968	SmpB-tmRNA interface; other site
196162003969	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
196162003970	active site
196162003971	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162003972	dimerization interface [polypeptide binding]; other site
196162003973	putative DNA binding site [nucleotide binding]; other site
196162003974	putative Zn2+ binding site [ion binding]; other site
196162003975	Actin depolymerization factor/cofilin- and gelsolin-like domains; Region: ADF_gelsolin; cl15697
196162003976	RibD C-terminal domain; Region: RibD_C; cl17279
196162003977	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162003978	hydrophobic ligand binding site; other site
196162003979	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196162003980	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162003981	active site
196162003982	Clostripain family; Region: Peptidase_C11; pfam03415
196162003983	Bacterial Ig-like domain (group 1); Region: BID_1; smart00634
196162003984	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
196162003985	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
196162003986	nucleotide binding site/active site [active]
196162003987	HIT family signature motif; other site
196162003988	catalytic residue [active]
196162003989	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162003990	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162003991	NAD(P) binding site [chemical binding]; other site
196162003992	active site
196162003993	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
196162003994	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162003995	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162003996	hypothetical protein; Validated; Region: PRK00228
196162003997	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
196162003998	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196162003999	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162004000	ATP binding site [chemical binding]; other site
196162004001	putative Mg++ binding site [ion binding]; other site
196162004002	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162004003	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
196162004004	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162004005	dimerization interface [polypeptide binding]; other site
196162004006	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
196162004007	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
196162004008	dimer interface [polypeptide binding]; other site
196162004009	putative CheW interface [polypeptide binding]; other site
196162004010	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162004011	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
196162004012	AsnC family; Region: AsnC_trans_reg; pfam01037
196162004013	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
196162004014	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
196162004015	dimer interface [polypeptide binding]; other site
196162004016	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
196162004017	active site
196162004018	Fe binding site [ion binding]; other site
196162004019	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162004020	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162004021	putative substrate translocation pore; other site
196162004022	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196162004023	MarR family; Region: MarR; pfam01047
196162004024	MarR family; Region: MarR_2; cl17246
196162004025	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
196162004026	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
196162004027	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
196162004028	active site
196162004029	metal binding site [ion binding]; metal-binding site
196162004030	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
196162004031	enoyl-CoA hydratase; Provisional; Region: PRK06688
196162004032	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162004033	substrate binding site [chemical binding]; other site
196162004034	oxyanion hole (OAH) forming residues; other site
196162004035	trimer interface [polypeptide binding]; other site
196162004036	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
196162004037	Isochorismatase family; Region: Isochorismatase; pfam00857
196162004038	catalytic triad [active]
196162004039	metal binding site [ion binding]; metal-binding site
196162004040	conserved cis-peptide bond; other site
196162004041	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162004042	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196162004043	nucleotide binding site [chemical binding]; other site
196162004044	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196162004045	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196162004046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162004047	dimer interface [polypeptide binding]; other site
196162004048	conserved gate region; other site
196162004049	putative PBP binding loops; other site
196162004050	ABC-ATPase subunit interface; other site
196162004051	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162004052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162004053	dimer interface [polypeptide binding]; other site
196162004054	conserved gate region; other site
196162004055	putative PBP binding loops; other site
196162004056	ABC-ATPase subunit interface; other site
196162004057	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
196162004058	putative active cleft [active]
196162004059	dimerization interface [polypeptide binding]; other site
196162004060	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
196162004061	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
196162004062	active site
196162004063	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
196162004064	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
196162004065	nudix motif; other site
196162004066	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
196162004067	MPN+ (JAMM) motif; other site
196162004068	Zinc-binding site [ion binding]; other site
196162004069	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
196162004070	MoaE interaction surface [polypeptide binding]; other site
196162004071	MoeB interaction surface [polypeptide binding]; other site
196162004072	thiocarboxylated glycine; other site
196162004073	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
196162004074	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
196162004075	dimer interface [polypeptide binding]; other site
196162004076	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162004077	catalytic residue [active]
196162004078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162004079	PAS fold; Region: PAS_3; pfam08447
196162004080	putative active site [active]
196162004081	heme pocket [chemical binding]; other site
196162004082	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
196162004083	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
196162004084	glutamate racemase; Provisional; Region: PRK00865
196162004085	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
196162004086	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162004087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004088	active site
196162004089	phosphorylation site [posttranslational modification]
196162004090	intermolecular recognition site; other site
196162004091	dimerization interface [polypeptide binding]; other site
196162004092	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162004093	DNA binding residues [nucleotide binding]
196162004094	dimerization interface [polypeptide binding]; other site
196162004095	Histidine kinase; Region: HisKA_3; pfam07730
196162004096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004097	ATP binding site [chemical binding]; other site
196162004098	Mg2+ binding site [ion binding]; other site
196162004099	G-X-G motif; other site
196162004100	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162004101	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162004102	Walker A/P-loop; other site
196162004103	ATP binding site [chemical binding]; other site
196162004104	Q-loop/lid; other site
196162004105	ABC transporter signature motif; other site
196162004106	Walker B; other site
196162004107	D-loop; other site
196162004108	H-loop/switch region; other site
196162004109	ribonuclease PH; Reviewed; Region: rph; PRK00173
196162004110	Ribonuclease PH; Region: RNase_PH_bact; cd11362
196162004111	hexamer interface [polypeptide binding]; other site
196162004112	active site
196162004113	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
196162004114	active site
196162004115	dimerization interface [polypeptide binding]; other site
196162004116	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
196162004117	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162004118	putative acyl-acceptor binding pocket; other site
196162004119	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
196162004120	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162004121	catalytic triad [active]
196162004122	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
196162004123	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
196162004124	PDGLE domain; Region: PDGLE; pfam13190
196162004125	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
196162004126	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196162004127	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196162004128	Walker A/P-loop; other site
196162004129	ATP binding site [chemical binding]; other site
196162004130	Q-loop/lid; other site
196162004131	ABC transporter signature motif; other site
196162004132	Walker B; other site
196162004133	D-loop; other site
196162004134	H-loop/switch region; other site
196162004135	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
196162004136	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
196162004137	oligomerisation interface [polypeptide binding]; other site
196162004138	mobile loop; other site
196162004139	roof hairpin; other site
196162004140	Penicillin amidase; Region: Penicil_amidase; pfam01804
196162004141	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
196162004142	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
196162004143	active site
196162004144	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
196162004145	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162004146	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
196162004147	iron-sulfur cluster [ion binding]; other site
196162004148	[2Fe-2S] cluster binding site [ion binding]; other site
196162004149	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
196162004150	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162004151	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162004152	DNA binding residues [nucleotide binding]
196162004153	dimerization interface [polypeptide binding]; other site
196162004154	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
196162004155	NdvC_like  proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; Region: CESA_NdvC_like; cd06435
196162004156	Ligand binding site; other site
196162004157	DXD motif; other site
196162004158	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
196162004159	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162004160	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162004161	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
196162004162	putative active site [active]
196162004163	heme pocket [chemical binding]; other site
196162004164	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004165	dimer interface [polypeptide binding]; other site
196162004166	phosphorylation site [posttranslational modification]
196162004167	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004168	ATP binding site [chemical binding]; other site
196162004169	Mg2+ binding site [ion binding]; other site
196162004170	G-X-G motif; other site
196162004171	Pirin-related protein [General function prediction only]; Region: COG1741
196162004172	Pirin; Region: Pirin; pfam02678
196162004173	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
196162004174	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
196162004175	Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852
196162004176	active site
196162004177	catalytic triad [active]
196162004178	PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120
196162004179	PA/protease or protease-like domain interface [polypeptide binding]; other site
196162004180	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
196162004181	catalytic residues [active]
196162004182	Helix-turn-helix domain; Region: HTH_20; pfam12840
196162004183	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162004184	putative DNA binding site [nucleotide binding]; other site
196162004185	putative Zn2+ binding site [ion binding]; other site
196162004186	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
196162004187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162004188	putative substrate translocation pore; other site
196162004189	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
196162004190	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
196162004191	[4Fe-4S] binding site [ion binding]; other site
196162004192	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196162004193	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196162004194	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196162004195	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
196162004196	molybdopterin cofactor binding site; other site
196162004197	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
196162004198	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
196162004199	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
196162004200	Hemerythrin-like domain; Region: Hr-like; cd12108
196162004201	Fe binding site [ion binding]; other site
196162004202	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
196162004203	catalytic site [active]
196162004204	putative active site [active]
196162004205	putative substrate binding site [chemical binding]; other site
196162004206	dimer interface [polypeptide binding]; other site
196162004207	Methylamine utilisation protein MauE; Region: MauE; pfam07291
196162004208	Thioredoxin; Region: Thioredoxin_4; cl17273
196162004209	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
196162004210	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162004211	active site
196162004212	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
196162004213	adenosine deaminase; Provisional; Region: PRK09358
196162004214	active site
196162004215	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162004216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
196162004217	active site
196162004218	phosphorylation site [posttranslational modification]
196162004219	intermolecular recognition site; other site
196162004220	dimerization interface [polypeptide binding]; other site
196162004221	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162004222	DNA binding residues [nucleotide binding]
196162004223	dimerization interface [polypeptide binding]; other site
196162004224	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196162004225	metal binding site [ion binding]; metal-binding site
196162004226	Cupin domain; Region: Cupin_2; cl17218
196162004227	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
196162004228	proline aminopeptidase P II; Provisional; Region: PRK10879
196162004229	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
196162004230	active site
196162004231	Protease prsW family; Region: PrsW-protease; pfam13367
196162004232	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
196162004233	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
196162004234	G1 box; other site
196162004235	G1 box; other site
196162004236	GTP/Mg2+ binding site [chemical binding]; other site
196162004237	GTP/Mg2+ binding site [chemical binding]; other site
196162004238	G2 box; other site
196162004239	G2 box; other site
196162004240	Switch I region; other site
196162004241	Switch I region; other site
196162004242	G3 box; other site
196162004243	Switch II region; other site
196162004244	G4 box; other site
196162004245	YfjP GTPase; Region: YfjP; cd11383
196162004246	G1 box; other site
196162004247	GTP/Mg2+ binding site [chemical binding]; other site
196162004248	Switch I region; other site
196162004249	G2 box; other site
196162004250	Switch II region; other site
196162004251	G3 box; other site
196162004252	G4 box; other site
196162004253	G5 box; other site
196162004254	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196162004255	dimer interface [polypeptide binding]; other site
196162004256	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
196162004257	ssDNA binding site [nucleotide binding]; other site
196162004258	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196162004259	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
196162004260	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162004261	Walker A/P-loop; other site
196162004262	ATP binding site [chemical binding]; other site
196162004263	Q-loop/lid; other site
196162004264	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162004265	ABC transporter signature motif; other site
196162004266	Walker B; other site
196162004267	D-loop; other site
196162004268	ABC transporter; Region: ABC_tran_2; pfam12848
196162004269	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162004270	MarR family; Region: MarR_2; cl17246
196162004271	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
196162004272	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162004273	dimer interface [polypeptide binding]; other site
196162004274	active site
196162004275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
196162004276	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162004277	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
196162004278	active site
196162004279	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
196162004280	active site
196162004281	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
196162004282	apolar tunnel; other site
196162004283	heme binding site [chemical binding]; other site
196162004284	dimerization interface [polypeptide binding]; other site
196162004285	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
196162004286	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
196162004287	Mechanosensitive ion channel; Region: MS_channel; pfam00924
196162004288	Repair protein; Region: Repair_PSII; pfam04536
196162004289	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
196162004290	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
196162004291	Zn binding site [ion binding]; other site
196162004292	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
196162004293	Chromate transporter; Region: Chromate_transp; pfam02417
196162004294	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162004295	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
196162004296	TIGR03086 family protein; Region: TIGR03086
196162004297	Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719
196162004298	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
196162004299	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
196162004300	active site
196162004301	HIGH motif; other site
196162004302	KMSKS motif; other site
196162004303	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
196162004304	tRNA binding surface [nucleotide binding]; other site
196162004305	anticodon binding site; other site
196162004306	hypothetical protein; Provisional; Region: PRK09256
196162004307	CoA binding domain; Region: CoA_binding; cl17356
196162004308	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162004309	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162004310	active site
196162004311	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
196162004312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004313	dimer interface [polypeptide binding]; other site
196162004314	phosphorylation site [posttranslational modification]
196162004315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004316	ATP binding site [chemical binding]; other site
196162004317	Mg2+ binding site [ion binding]; other site
196162004318	G-X-G motif; other site
196162004319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004320	Response regulator receiver domain; Region: Response_reg; pfam00072
196162004321	active site
196162004322	phosphorylation site [posttranslational modification]
196162004323	intermolecular recognition site; other site
196162004324	dimerization interface [polypeptide binding]; other site
196162004325	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
196162004326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004327	active site
196162004328	phosphorylation site [posttranslational modification]
196162004329	intermolecular recognition site; other site
196162004330	dimerization interface [polypeptide binding]; other site
196162004331	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
196162004332	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162004333	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162004334	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162004335	DNA binding residues [nucleotide binding]
196162004336	enoyl-CoA hydratase; Provisional; Region: PRK08260
196162004337	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162004338	substrate binding site [chemical binding]; other site
196162004339	oxyanion hole (OAH) forming residues; other site
196162004340	trimer interface [polypeptide binding]; other site
196162004341	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
196162004342	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
196162004343	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
196162004344	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
196162004345	Transcriptional regulator [Transcription]; Region: LytR; COG1316
196162004346	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
196162004347	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
196162004348	Probable Catalytic site; other site
196162004349	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
196162004350	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
196162004351	Probable Catalytic site; other site
196162004352	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
196162004353	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162004354	UDP-galactopyranose mutase; Region: GLF; pfam03275
196162004355	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
196162004356	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162004357	active site
196162004358	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196162004359	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
196162004360	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
196162004361	Walker A/P-loop; other site
196162004362	ATP binding site [chemical binding]; other site
196162004363	Q-loop/lid; other site
196162004364	ABC transporter signature motif; other site
196162004365	Walker B; other site
196162004366	D-loop; other site
196162004367	H-loop/switch region; other site
196162004368	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
196162004369	amidase catalytic site [active]
196162004370	Zn binding residues [ion binding]; other site
196162004371	substrate binding site [chemical binding]; other site
196162004372	Family description; Region: VCBS; pfam13517
196162004373	Family description; Region: VCBS; pfam13517
196162004374	Family description; Region: VCBS; pfam13517
196162004375	Family description; Region: VCBS; pfam13517
196162004376	Family description; Region: VCBS; pfam13517
196162004377	TIGR03089 family protein; Region: TIGR03089
196162004378	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162004379	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
196162004380	active site
196162004381	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
196162004382	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
196162004383	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
196162004384	LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606
196162004385	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
196162004386	phosphate binding site [ion binding]; other site
196162004387	dimer interface [polypeptide binding]; other site
196162004388	Transcription factor WhiB; Region: Whib; pfam02467
196162004389	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
196162004390	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162004391	active site
196162004392	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
196162004393	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
196162004394	NAD(P) binding site [chemical binding]; other site
196162004395	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
196162004396	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
196162004397	dimer interface [polypeptide binding]; other site
196162004398	active site
196162004399	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162004400	substrate binding site [chemical binding]; other site
196162004401	catalytic residue [active]
196162004402	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162004403	active site
196162004404	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162004405	catalytic tetrad [active]
196162004406	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
196162004407	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
196162004408	active site
196162004409	putative substrate binding pocket [chemical binding]; other site
196162004410	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162004411	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162004412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162004413	dimer interface [polypeptide binding]; other site
196162004414	conserved gate region; other site
196162004415	putative PBP binding loops; other site
196162004416	ABC-ATPase subunit interface; other site
196162004417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162004418	dimer interface [polypeptide binding]; other site
196162004419	putative PBP binding loops; other site
196162004420	ABC-ATPase subunit interface; other site
196162004421	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196162004422	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196162004423	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
196162004424	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162004425	NAD(P) binding site [chemical binding]; other site
196162004426	catalytic residues [active]
196162004427	Transcriptional regulators [Transcription]; Region: GntR; COG1802
196162004428	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162004429	DNA-binding site [nucleotide binding]; DNA binding site
196162004430	FCD domain; Region: FCD; pfam07729
196162004431	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
196162004432	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
196162004433	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
196162004434	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
196162004435	active site
196162004436	substrate binding site [chemical binding]; other site
196162004437	metal binding site [ion binding]; metal-binding site
196162004438	Uncharacterized conserved protein [Function unknown]; Region: COG2835
196162004439	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
196162004440	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
196162004441	Acyltransferase family; Region: Acyl_transf_3; pfam01757
196162004442	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
196162004443	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
196162004444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162004445	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
196162004446	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162004447	FeS/SAM binding site; other site
196162004448	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
196162004449	Protein of unknown function (DUF808); Region: DUF808; cl01002
196162004450	Adenosylhomocysteinase; Provisional; Region: PTZ00075
196162004451	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
196162004452	homotetramer interface [polypeptide binding]; other site
196162004453	ligand binding site [chemical binding]; other site
196162004454	catalytic site [active]
196162004455	NAD binding site [chemical binding]; other site
196162004456	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162004457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004458	active site
196162004459	phosphorylation site [posttranslational modification]
196162004460	intermolecular recognition site; other site
196162004461	dimerization interface [polypeptide binding]; other site
196162004462	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162004463	DNA binding site [nucleotide binding]
196162004464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162004465	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162004466	dimerization interface [polypeptide binding]; other site
196162004467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004468	dimer interface [polypeptide binding]; other site
196162004469	phosphorylation site [posttranslational modification]
196162004470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004471	ATP binding site [chemical binding]; other site
196162004472	Mg2+ binding site [ion binding]; other site
196162004473	G-X-G motif; other site
196162004474	lipoprotein LpqB; Provisional; Region: PRK13613
196162004475	Sporulation and spore germination; Region: Germane; pfam10646
196162004476	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
196162004477	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162004478	active site
196162004479	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
196162004480	30S subunit binding site; other site
196162004481	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162004482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004483	active site
196162004484	phosphorylation site [posttranslational modification]
196162004485	intermolecular recognition site; other site
196162004486	dimerization interface [polypeptide binding]; other site
196162004487	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162004488	dimerization interface [polypeptide binding]; other site
196162004489	DNA binding residues [nucleotide binding]
196162004490	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
196162004491	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
196162004492	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
196162004493	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
196162004494	SEC-C motif; Region: SEC-C; pfam02810
196162004495	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
196162004496	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162004497	sec-independent translocase; Provisional; Region: PRK01371
196162004498	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
196162004499	antiporter inner membrane protein; Provisional; Region: PRK11670
196162004500	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
196162004501	Walker A motif; other site
196162004502	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
196162004503	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
196162004504	PRC-barrel domain; Region: PRC; pfam05239
196162004505	MgtE intracellular N domain; Region: MgtE_N; smart00924
196162004506	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
196162004507	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162004508	putative catalytic site [active]
196162004509	putative metal binding site [ion binding]; other site
196162004510	putative phosphate binding site [ion binding]; other site
196162004511	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162004512	PLD-like domain; Region: PLDc_2; pfam13091
196162004513	putative active site [active]
196162004514	catalytic site [active]
196162004515	PLD-like domain; Region: PLDc_2; pfam13091
196162004516	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162004517	putative active site [active]
196162004518	catalytic site [active]
196162004519	LicD family; Region: LicD; pfam04991
196162004520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162004521	S-adenosylmethionine binding site [chemical binding]; other site
196162004522	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
196162004523	PLD-like domain; Region: PLDc_2; pfam13091
196162004524	putative active site [active]
196162004525	catalytic site [active]
196162004526	PLD-like domain; Region: PLDc_2; pfam13091
196162004527	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162004528	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162004529	putative active site [active]
196162004530	putative active site [active]
196162004531	catalytic site [active]
196162004532	catalytic site [active]
196162004533	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162004534	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162004535	active site
196162004536	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162004537	putative catalytic site [active]
196162004538	putative metal binding site [ion binding]; other site
196162004539	putative phosphate binding site [ion binding]; other site
196162004540	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
196162004541	putative active site [active]
196162004542	putative catalytic site [active]
196162004543	TrkA-N domain; Region: TrkA_N; pfam02254
196162004544	Protein of unknown function (DUF1012); Region: DUF1012; pfam06241
196162004545	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162004546	catalytic core [active]
196162004547	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196162004548	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162004549	active site
196162004550	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
196162004551	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
196162004552	active site
196162004553	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
196162004554	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
196162004555	classical (c) SDRs; Region: SDR_c; cd05233
196162004556	NAD(P) binding site [chemical binding]; other site
196162004557	active site
196162004558	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
196162004559	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162004560	P-loop; other site
196162004561	Magnesium ion binding site [ion binding]; other site
196162004562	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162004563	Magnesium ion binding site [ion binding]; other site
196162004564	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
196162004565	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
196162004566	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196162004567	ATP binding site [chemical binding]; other site
196162004568	Mg++ binding site [ion binding]; other site
196162004569	motif III; other site
196162004570	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162004571	nucleotide binding region [chemical binding]; other site
196162004572	ATP-binding site [chemical binding]; other site
196162004573	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
196162004574	dinuclear metal binding motif [ion binding]; other site
196162004575	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
196162004576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162004577	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162004578	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
196162004579	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
196162004580	ATP binding site [chemical binding]; other site
196162004581	substrate interface [chemical binding]; other site
196162004582	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196162004583	active site residue [active]
196162004584	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
196162004585	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162004586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162004587	Walker A motif; other site
196162004588	ATP binding site [chemical binding]; other site
196162004589	Walker B motif; other site
196162004590	arginine finger; other site
196162004591	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
196162004592	Protein of unknown function DUF58; Region: DUF58; pfam01882
196162004593	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
196162004594	DNA binding site [nucleotide binding]
196162004595	active site
196162004596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162004597	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
196162004598	Walker A/P-loop; other site
196162004599	ATP binding site [chemical binding]; other site
196162004600	Q-loop/lid; other site
196162004601	ABC transporter signature motif; other site
196162004602	Walker B; other site
196162004603	D-loop; other site
196162004604	H-loop/switch region; other site
196162004605	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
196162004606	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
196162004607	Protein of unknown function (DUF1116); Region: DUF1116; pfam06545
196162004608	membrane protein FdrA; Validated; Region: PRK06091
196162004609	CoA binding domain; Region: CoA_binding; cl17356
196162004610	Protein of unknown function (DUF2877); Region: DUF2877; pfam11392
196162004611	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162004612	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
196162004613	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162004614	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
196162004615	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162004616	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162004617	catalytic loop [active]
196162004618	iron binding site [ion binding]; other site
196162004619	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162004620	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162004621	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162004622	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162004623	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
196162004624	putative hydrophobic ligand binding site [chemical binding]; other site
196162004625	amidase; Provisional; Region: PRK07486
196162004626	Amidase; Region: Amidase; pfam01425
196162004627	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196162004628	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162004629	putative acyl-acceptor binding pocket; other site
196162004630	cytosine deaminase; Validated; Region: PRK07572
196162004631	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
196162004632	active site
196162004633	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
196162004634	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
196162004635	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
196162004636	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
196162004637	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
196162004638	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162004639	active site
196162004640	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
196162004641	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
196162004642	classical (c) SDRs; Region: SDR_c; cd05233
196162004643	short chain dehydrogenase; Provisional; Region: PRK06123
196162004644	NAD(P) binding site [chemical binding]; other site
196162004645	active site
196162004646	TrkA-C domain; Region: TrkA_C; pfam02080
196162004647	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
196162004648	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
196162004649	putative substrate binding site [chemical binding]; other site
196162004650	nucleotide binding site [chemical binding]; other site
196162004651	nucleotide binding site [chemical binding]; other site
196162004652	homodimer interface [polypeptide binding]; other site
196162004653	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; cl17559
196162004654	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162004655	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162004656	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
196162004657	conserved cys residue [active]
196162004658	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
196162004659	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196162004660	Family description; Region: UvrD_C_2; pfam13538
196162004661	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
196162004662	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196162004663	Part of AAA domain; Region: AAA_19; pfam13245
196162004664	Family description; Region: UvrD_C_2; pfam13538
196162004665	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
196162004666	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196162004667	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162004668	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
196162004669	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
196162004670	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
196162004671	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
196162004672	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
196162004673	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
196162004674	putative NADH binding site [chemical binding]; other site
196162004675	putative active site [active]
196162004676	nudix motif; other site
196162004677	putative metal binding site [ion binding]; other site
196162004678	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
196162004679	catalytic residues [active]
196162004680	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
196162004681	Part of AAA domain; Region: AAA_19; pfam13245
196162004682	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
196162004683	Family description; Region: UvrD_C_2; pfam13538
196162004684	HRDC domain; Region: HRDC; pfam00570
196162004685	Transcription factor WhiB; Region: Whib; pfam02467
196162004686	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
196162004687	enoyl-CoA hydratase; Provisional; Region: PRK06688
196162004688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162004689	substrate binding site [chemical binding]; other site
196162004690	oxyanion hole (OAH) forming residues; other site
196162004691	trimer interface [polypeptide binding]; other site
196162004692	hypothetical protein; Provisional; Region: PRK07945
196162004693	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
196162004694	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
196162004695	active site
196162004696	Protein of unknown function DUF45; Region: DUF45; pfam01863
196162004697	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
196162004698	nudix motif; other site
196162004699	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
196162004700	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
196162004701	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
196162004702	MoaE homodimer interface [polypeptide binding]; other site
196162004703	MoaD interaction [polypeptide binding]; other site
196162004704	active site residues [active]
196162004705	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
196162004706	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
196162004707	protein binding site [polypeptide binding]; other site
196162004708	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
196162004709	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
196162004710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162004711	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162004712	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
196162004713	Chromate transporter; Region: Chromate_transp; pfam02417
196162004714	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
196162004715	PQQ-like domain; Region: PQQ_2; pfam13360
196162004716	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162004717	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
196162004718	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196162004719	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
196162004720	ATP binding site [chemical binding]; other site
196162004721	Walker A motif; other site
196162004722	hexamer interface [polypeptide binding]; other site
196162004723	Walker B motif; other site
196162004724	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
196162004725	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162004726	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162004727	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
196162004728	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
196162004729	NodB motif; other site
196162004730	putative active site [active]
196162004731	putative catalytic site [active]
196162004732	putative Zn binding site [ion binding]; other site
196162004733	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
196162004734	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
196162004735	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
196162004736	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
196162004737	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196162004738	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
196162004739	active site
196162004740	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196162004741	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
196162004742	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
196162004743	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162004744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004745	active site
196162004746	phosphorylation site [posttranslational modification]
196162004747	intermolecular recognition site; other site
196162004748	dimerization interface [polypeptide binding]; other site
196162004749	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162004750	DNA binding site [nucleotide binding]
196162004751	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
196162004752	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
196162004753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004754	dimer interface [polypeptide binding]; other site
196162004755	phosphorylation site [posttranslational modification]
196162004756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004757	ATP binding site [chemical binding]; other site
196162004758	Mg2+ binding site [ion binding]; other site
196162004759	G-X-G motif; other site
196162004760	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162004761	active site
196162004762	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
196162004763	Ligand binding site; other site
196162004764	Putative Catalytic site; other site
196162004765	DXD motif; other site
196162004766	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162004767	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196162004768	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
196162004769	AAA-like domain; Region: AAA_10; pfam12846
196162004770	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162004771	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162004772	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
196162004773	TrwC relaxase; Region: TrwC; pfam08751
196162004774	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
196162004775	AAA domain; Region: AAA_30; pfam13604
196162004776	Family description; Region: UvrD_C_2; pfam13538
196162004777	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
196162004778	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
196162004779	active site
196162004780	metal binding site [ion binding]; metal-binding site
196162004781	interdomain interaction site; other site
196162004782	Domain of unknown function (DUF932); Region: DUF932; pfam06067
196162004783	ParB-like nuclease domain; Region: ParBc; pfam02195
196162004784	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
196162004785	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
196162004786	Mrr N-terminal domain; Region: Mrr_N; pfam14338
196162004787	Restriction endonuclease; Region: Mrr_cat; pfam04471
196162004788	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
196162004789	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
196162004790	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
196162004791	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162004792	active site
196162004793	DNA binding site [nucleotide binding]
196162004794	Int/Topo IB signature motif; other site
196162004795	Integrase core domain; Region: rve; pfam00665
196162004796	Integrase core domain; Region: rve_3; pfam13683
196162004797	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162004798	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
196162004799	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196162004800	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
196162004801	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
196162004802	active site
196162004803	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
196162004804	Cupin domain; Region: Cupin_2; cl17218
196162004805	Predicted membrane protein [Function unknown]; Region: COG2246
196162004806	GtrA-like protein; Region: GtrA; pfam04138
196162004807	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162004808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004809	active site
196162004810	phosphorylation site [posttranslational modification]
196162004811	intermolecular recognition site; other site
196162004812	dimerization interface [polypeptide binding]; other site
196162004813	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162004814	DNA binding site [nucleotide binding]
196162004815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162004816	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162004817	dimerization interface [polypeptide binding]; other site
196162004818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004819	dimer interface [polypeptide binding]; other site
196162004820	phosphorylation site [posttranslational modification]
196162004821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004822	ATP binding site [chemical binding]; other site
196162004823	Mg2+ binding site [ion binding]; other site
196162004824	G-X-G motif; other site
196162004825	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
196162004826	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
196162004827	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
196162004828	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
196162004829	Phosphoesterase family; Region: Phosphoesterase; pfam04185
196162004830	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
196162004831	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
196162004832	Ligand binding site; other site
196162004833	Putative Catalytic site; other site
196162004834	DXD motif; other site
196162004835	FtsX-like permease family; Region: FtsX; pfam02687
196162004836	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162004837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162004838	Walker A/P-loop; other site
196162004839	ATP binding site [chemical binding]; other site
196162004840	Q-loop/lid; other site
196162004841	ABC transporter signature motif; other site
196162004842	Walker B; other site
196162004843	D-loop; other site
196162004844	H-loop/switch region; other site
196162004845	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
196162004846	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162004847	Walker A/P-loop; other site
196162004848	ATP binding site [chemical binding]; other site
196162004849	Q-loop/lid; other site
196162004850	ABC transporter signature motif; other site
196162004851	Walker B; other site
196162004852	D-loop; other site
196162004853	H-loop/switch region; other site
196162004854	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162004855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004856	active site
196162004857	phosphorylation site [posttranslational modification]
196162004858	intermolecular recognition site; other site
196162004859	dimerization interface [polypeptide binding]; other site
196162004860	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162004861	DNA binding site [nucleotide binding]
196162004862	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162004863	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162004864	dimerization interface [polypeptide binding]; other site
196162004865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004866	dimer interface [polypeptide binding]; other site
196162004867	phosphorylation site [posttranslational modification]
196162004868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004869	ATP binding site [chemical binding]; other site
196162004870	Mg2+ binding site [ion binding]; other site
196162004871	G-X-G motif; other site
196162004872	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162004873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162004874	active site
196162004875	phosphorylation site [posttranslational modification]
196162004876	intermolecular recognition site; other site
196162004877	dimerization interface [polypeptide binding]; other site
196162004878	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162004879	DNA binding site [nucleotide binding]
196162004880	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162004881	HAMP domain; Region: HAMP; pfam00672
196162004882	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162004883	dimer interface [polypeptide binding]; other site
196162004884	phosphorylation site [posttranslational modification]
196162004885	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162004886	ATP binding site [chemical binding]; other site
196162004887	Mg2+ binding site [ion binding]; other site
196162004888	G-X-G motif; other site
196162004889	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
196162004890	Phage integrase family; Region: Phage_integrase; pfam00589
196162004891	active site
196162004892	DNA binding site [nucleotide binding]
196162004893	Int/Topo IB signature motif; other site
196162004894	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
196162004895	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
196162004896	Cation efflux family; Region: Cation_efflux; pfam01545
196162004897	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
196162004898	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196162004899	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196162004900	ligand binding site [chemical binding]; other site
196162004901	flexible hinge region; other site
196162004902	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196162004903	putative switch regulator; other site
196162004904	non-specific DNA interactions [nucleotide binding]; other site
196162004905	DNA binding site [nucleotide binding]
196162004906	sequence specific DNA binding site [nucleotide binding]; other site
196162004907	putative cAMP binding site [chemical binding]; other site
196162004908	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
196162004909	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
196162004910	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
196162004911	D-pathway; other site
196162004912	Low-spin heme binding site [chemical binding]; other site
196162004913	Putative water exit pathway; other site
196162004914	Binuclear center (active site) [active]
196162004915	K-pathway; other site
196162004916	Putative proton exit pathway; other site
196162004917	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
196162004918	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162004919	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162004920	catalytic residue [active]
196162004921	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
196162004922	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
196162004923	putative DNA binding site [nucleotide binding]; other site
196162004924	putative Zn2+ binding site [ion binding]; other site
196162004925	AsnC family; Region: AsnC_trans_reg; pfam01037
196162004926	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
196162004927	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
196162004928	active site
196162004929	putative substrate binding pocket [chemical binding]; other site
196162004930	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
196162004931	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162004932	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
196162004933	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
196162004934	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162004935	catalytic residue [active]
196162004936	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
196162004937	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162004938	active site
196162004939	methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271
196162004940	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
196162004941	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162004942	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
196162004943	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196162004944	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196162004945	probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316
196162004946	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196162004947	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196162004948	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162004949	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
196162004950	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162004951	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162004952	xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970
196162004953	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162004954	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162004955	phenylhydantoinase; Validated; Region: PRK08323
196162004956	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162004957	active site
196162004958	Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630
196162004959	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162004960	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
196162004961	Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631
196162004962	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162004963	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162004964	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
196162004965	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
196162004966	XdhC Rossmann domain; Region: XdhC_C; pfam13478
196162004967	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
196162004968	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
196162004969	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
196162004970	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
196162004971	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196162004972	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196162004973	ligand binding site [chemical binding]; other site
196162004974	flexible hinge region; other site
196162004975	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196162004976	putative switch regulator; other site
196162004977	non-specific DNA interactions [nucleotide binding]; other site
196162004978	DNA binding site [nucleotide binding]
196162004979	sequence specific DNA binding site [nucleotide binding]; other site
196162004980	putative cAMP binding site [chemical binding]; other site
196162004981	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162004982	Domain of unknown function (DUF427); Region: DUF427; pfam04248
196162004983	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
196162004984	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
196162004985	motif II; other site
196162004986	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
196162004987	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196162004988	DNA binding residues [nucleotide binding]
196162004989	dimer interface [polypeptide binding]; other site
196162004990	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
196162004991	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162004992	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162004993	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
196162004994	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
196162004995	active site
196162004996	catalytic residues [active]
196162004997	metal binding site [ion binding]; metal-binding site
196162004998	DmpG-like communication domain; Region: DmpG_comm; pfam07836
196162004999	acetaldehyde dehydrogenase; Validated; Region: PRK08300
196162005000	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
196162005001	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
196162005002	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
196162005003	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162005004	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
196162005005	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162005006	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
196162005007	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805
196162005008	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
196162005009	N- and C-terminal domain interface [polypeptide binding]; other site
196162005010	active site
196162005011	MgATP binding site [chemical binding]; other site
196162005012	catalytic site [active]
196162005013	metal binding site [ion binding]; metal-binding site
196162005014	xylulose binding site [chemical binding]; other site
196162005015	putative homodimer interface [polypeptide binding]; other site
196162005016	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
196162005017	intersubunit interface [polypeptide binding]; other site
196162005018	active site
196162005019	Zn2+ binding site [ion binding]; other site
196162005020	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
196162005021	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162005022	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162005023	catalytic residue [active]
196162005024	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162005025	glutamate dehydrogenase; Provisional; Region: PRK09414
196162005026	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
196162005027	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
196162005028	NAD(P) binding site [chemical binding]; other site
196162005029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196162005030	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196162005031	ligand binding site [chemical binding]; other site
196162005032	flexible hinge region; other site
196162005033	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
196162005034	putative switch regulator; other site
196162005035	non-specific DNA interactions [nucleotide binding]; other site
196162005036	DNA binding site [nucleotide binding]
196162005037	sequence specific DNA binding site [nucleotide binding]; other site
196162005038	putative cAMP binding site [chemical binding]; other site
196162005039	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
196162005040	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
196162005041	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162005042	Soluble P-type ATPase [General function prediction only]; Region: COG4087
196162005043	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196162005044	metal-binding site [ion binding]
196162005045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162005046	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162005047	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162005048	Walker A/P-loop; other site
196162005049	ATP binding site [chemical binding]; other site
196162005050	Q-loop/lid; other site
196162005051	ABC transporter signature motif; other site
196162005052	Walker B; other site
196162005053	D-loop; other site
196162005054	H-loop/switch region; other site
196162005055	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
196162005056	thioester reductase domain; Region: Thioester-redct; TIGR01746
196162005057	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
196162005058	putative NAD(P) binding site [chemical binding]; other site
196162005059	active site
196162005060	putative substrate binding site [chemical binding]; other site
196162005061	Predicted dehydrogenase [General function prediction only]; Region: COG5322
196162005062	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
196162005063	NAD(P) binding pocket [chemical binding]; other site
196162005064	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
196162005065	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
196162005066	Protein of unknown function (DUF1298); Region: DUF1298; pfam06974
196162005067	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
196162005068	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005069	ATP binding site [chemical binding]; other site
196162005070	Mg2+ binding site [ion binding]; other site
196162005071	G-X-G motif; other site
196162005072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162005073	active site
196162005074	phosphorylation site [posttranslational modification]
196162005075	intermolecular recognition site; other site
196162005076	dimerization interface [polypeptide binding]; other site
196162005077	Response regulator receiver domain; Region: Response_reg; pfam00072
196162005078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162005079	active site
196162005080	phosphorylation site [posttranslational modification]
196162005081	intermolecular recognition site; other site
196162005082	dimerization interface [polypeptide binding]; other site
196162005083	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
196162005084	YwiC-like protein; Region: YwiC; pfam14256
196162005085	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162005086	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
196162005087	ATP binding site [chemical binding]; other site
196162005088	putative Mg++ binding site [ion binding]; other site
196162005089	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162005090	nucleotide binding region [chemical binding]; other site
196162005091	ATP-binding site [chemical binding]; other site
196162005092	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
196162005093	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162005094	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162005095	DNA binding residues [nucleotide binding]
196162005096	Putative zinc-finger; Region: zf-HC2; pfam13490
196162005097	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
196162005098	Sulfatase; Region: Sulfatase; cl17466
196162005099	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162005100	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
196162005101	putative NAD(P) binding site [chemical binding]; other site
196162005102	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
196162005103	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196162005104	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162005105	RibD C-terminal domain; Region: RibD_C; cl17279
196162005106	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
196162005107	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
196162005108	dimerization interface [polypeptide binding]; other site
196162005109	active site
196162005110	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
196162005111	Catalytic site [active]
196162005112	Cellulose binding domain; Region: CBM_2; cl17741
196162005113	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
196162005114	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162005115	DNA-binding site [nucleotide binding]; DNA binding site
196162005116	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162005117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162005118	homodimer interface [polypeptide binding]; other site
196162005119	catalytic residue [active]
196162005120	putative transporter; Provisional; Region: PRK11021
196162005121	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
196162005122	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162005123	active site
196162005124	nucleotide binding site [chemical binding]; other site
196162005125	HIGH motif; other site
196162005126	KMSKS motif; other site
196162005127	Protein of unknown function (DUF445); Region: DUF445; pfam04286
196162005128	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196162005129	RNA binding surface [nucleotide binding]; other site
196162005130	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
196162005131	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
196162005132	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
196162005133	FOG: CBS domain [General function prediction only]; Region: COG0517
196162005134	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196162005135	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
196162005136	active site
196162005137	Predicted GTPases [General function prediction only]; Region: COG1162
196162005138	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
196162005139	GTPase/Zn-binding domain interface [polypeptide binding]; other site
196162005140	GTP/Mg2+ binding site [chemical binding]; other site
196162005141	G4 box; other site
196162005142	G1 box; other site
196162005143	Switch I region; other site
196162005144	G2 box; other site
196162005145	G3 box; other site
196162005146	Switch II region; other site
196162005147	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
196162005148	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
196162005149	hinge; other site
196162005150	active site
196162005151	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162005152	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162005153	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162005154	DNA binding residues [nucleotide binding]
196162005155	Putative zinc-finger; Region: zf-HC2; pfam13490
196162005156	Uncharacterized conserved protein [Function unknown]; Region: COG2135
196162005157	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571
196162005158	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
196162005159	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162005160	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162005161	DNA binding residues [nucleotide binding]
196162005162	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
196162005163	Predicted thioesterase [General function prediction only]; Region: COG5496
196162005164	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162005165	Coenzyme A binding pocket [chemical binding]; other site
196162005166	hypothetical protein; Provisional; Region: PRK05858
196162005167	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196162005168	PYR/PP interface [polypeptide binding]; other site
196162005169	dimer interface [polypeptide binding]; other site
196162005170	TPP binding site [chemical binding]; other site
196162005171	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196162005172	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
196162005173	TPP-binding site; other site
196162005174	dimer interface [polypeptide binding]; other site
196162005175	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
196162005176	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
196162005177	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
196162005178	Histidine kinase; Region: HisKA_2; pfam07568
196162005179	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005180	ATP binding site [chemical binding]; other site
196162005181	Mg2+ binding site [ion binding]; other site
196162005182	G-X-G motif; other site
196162005183	Transcription factor WhiB; Region: Whib; pfam02467
196162005184	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
196162005185	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162005186	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162005187	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162005188	DNA binding residues [nucleotide binding]
196162005189	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
196162005190	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
196162005191	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162005192	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196162005193	Walker A/P-loop; other site
196162005194	ATP binding site [chemical binding]; other site
196162005195	Q-loop/lid; other site
196162005196	ABC transporter signature motif; other site
196162005197	Walker B; other site
196162005198	D-loop; other site
196162005199	H-loop/switch region; other site
196162005200	FtsX-like permease family; Region: FtsX; pfam02687
196162005201	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196162005202	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162005203	Walker A/P-loop; other site
196162005204	ATP binding site [chemical binding]; other site
196162005205	Q-loop/lid; other site
196162005206	ABC transporter signature motif; other site
196162005207	Walker B; other site
196162005208	D-loop; other site
196162005209	H-loop/switch region; other site
196162005210	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162005211	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162005212	TrwC relaxase; Region: TrwC; pfam08751
196162005213	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
196162005214	AAA domain; Region: AAA_30; pfam13604
196162005215	Family description; Region: UvrD_C_2; pfam13538
196162005216	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162005217	non-specific DNA binding site [nucleotide binding]; other site
196162005218	salt bridge; other site
196162005219	sequence-specific DNA binding site [nucleotide binding]; other site
196162005220	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162005221	integrase; Provisional; Region: int; PHA02601
196162005222	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162005223	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162005224	active site
196162005225	DNA binding site [nucleotide binding]
196162005226	Int/Topo IB signature motif; other site
196162005227	Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055
196162005228	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
196162005229	Catalytic site [active]
196162005230	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
196162005231	Malic enzyme, N-terminal domain; Region: malic; pfam00390
196162005232	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
196162005233	NAD(P) binding pocket [chemical binding]; other site
196162005234	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162005235	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196162005236	NAD(P) binding site [chemical binding]; other site
196162005237	short chain dehydrogenase; Provisional; Region: PRK08219
196162005238	classical (c) SDRs; Region: SDR_c; cd05233
196162005239	NAD(P) binding site [chemical binding]; other site
196162005240	active site
196162005241	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
196162005242	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162005243	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
196162005244	Protein of unknown function (DUF419); Region: DUF419; cl15265
196162005245	Acetoacetate decarboxylase (ADC); Region: ADC; cl01919
196162005246	Sulfatase; Region: Sulfatase; cl17466
196162005247	alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270
196162005248	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
196162005249	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
196162005250	TPP-binding site [chemical binding]; other site
196162005251	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
196162005252	Transcriptional regulator [Transcription]; Region: LytR; COG1316
196162005253	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196162005254	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162005255	active site
196162005256	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
196162005257	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
196162005258	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
196162005259	active site
196162005260	HIGH motif; other site
196162005261	KMSK motif region; other site
196162005262	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
196162005263	tRNA binding surface [nucleotide binding]; other site
196162005264	anticodon binding site; other site
196162005265	diaminopimelate decarboxylase; Region: lysA; TIGR01048
196162005266	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
196162005267	active site
196162005268	substrate binding site [chemical binding]; other site
196162005269	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162005270	catalytic residues [active]
196162005271	dimer interface [polypeptide binding]; other site
196162005272	homoserine dehydrogenase; Provisional; Region: PRK06349
196162005273	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
196162005274	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
196162005275	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
196162005276	threonine synthase; Reviewed; Region: PRK06721
196162005277	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
196162005278	homodimer interface [polypeptide binding]; other site
196162005279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162005280	catalytic residue [active]
196162005281	homoserine kinase; Provisional; Region: PRK01212
196162005282	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
196162005283	transcription termination factor Rho; Provisional; Region: PRK12608
196162005284	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
196162005285	RNA binding site [nucleotide binding]; other site
196162005286	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
196162005287	multimer interface [polypeptide binding]; other site
196162005288	Walker A motif; other site
196162005289	ATP binding site [chemical binding]; other site
196162005290	Walker B motif; other site
196162005291	Response regulator receiver domain; Region: Response_reg; pfam00072
196162005292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162005293	active site
196162005294	phosphorylation site [posttranslational modification]
196162005295	intermolecular recognition site; other site
196162005296	dimerization interface [polypeptide binding]; other site
196162005297	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
196162005298	dimerization interface [polypeptide binding]; other site
196162005299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162005300	dimer interface [polypeptide binding]; other site
196162005301	phosphorylation site [posttranslational modification]
196162005302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005303	ATP binding site [chemical binding]; other site
196162005304	Mg2+ binding site [ion binding]; other site
196162005305	G-X-G motif; other site
196162005306	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
196162005307	peptide chain release factor 1; Validated; Region: prfA; PRK00591
196162005308	This domain is found in peptide chain release factors; Region: PCRF; smart00937
196162005309	RF-1 domain; Region: RF-1; pfam00472
196162005310	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
196162005311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162005312	S-adenosylmethionine binding site [chemical binding]; other site
196162005313	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
196162005314	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
196162005315	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
196162005316	Mg++ binding site [ion binding]; other site
196162005317	putative catalytic motif [active]
196162005318	substrate binding site [chemical binding]; other site
196162005319	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
196162005320	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
196162005321	ATP synthase subunit C; Region: ATP-synt_C; cl00466
196162005322	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
196162005323	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
196162005324	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
196162005325	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
196162005326	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
196162005327	beta subunit interaction interface [polypeptide binding]; other site
196162005328	Walker A motif; other site
196162005329	ATP binding site [chemical binding]; other site
196162005330	Walker B motif; other site
196162005331	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
196162005332	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
196162005333	core domain interface [polypeptide binding]; other site
196162005334	delta subunit interface [polypeptide binding]; other site
196162005335	epsilon subunit interface [polypeptide binding]; other site
196162005336	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
196162005337	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
196162005338	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
196162005339	alpha subunit interaction interface [polypeptide binding]; other site
196162005340	Walker A motif; other site
196162005341	ATP binding site [chemical binding]; other site
196162005342	Walker B motif; other site
196162005343	inhibitor binding site; inhibition site
196162005344	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
196162005345	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
196162005346	gamma subunit interface [polypeptide binding]; other site
196162005347	epsilon subunit interface [polypeptide binding]; other site
196162005348	LBP interface [polypeptide binding]; other site
196162005349	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
196162005350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196162005351	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196162005352	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162005353	FAD binding domain; Region: FAD_binding_4; pfam01565
196162005354	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
196162005355	DNA binding site [nucleotide binding]
196162005356	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162005357	putative substrate translocation pore; other site
196162005358	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
196162005359	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
196162005360	anti sigma factor interaction site; other site
196162005361	regulatory phosphorylation site [posttranslational modification]; other site
196162005362	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
196162005363	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
196162005364	B12 binding site [chemical binding]; other site
196162005365	cobalt ligand [ion binding]; other site
196162005366	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
196162005367	Ferritin-like domain; Region: Ferritin; pfam00210
196162005368	ferroxidase diiron center [ion binding]; other site
196162005369	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162005370	active site
196162005371	parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805
196162005372	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162005373	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162005374	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
196162005375	hypothetical protein; Provisional; Region: PRK03298
196162005376	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
196162005377	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
196162005378	dimer interface [polypeptide binding]; other site
196162005379	putative CheW interface [polypeptide binding]; other site
196162005380	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
196162005381	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162005382	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162005383	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
196162005384	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162005385	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162005386	benzoate transport; Region: 2A0115; TIGR00895
196162005387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162005388	putative substrate translocation pore; other site
196162005389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162005390	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
196162005391	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
196162005392	active site
196162005393	catalytic residues [active]
196162005394	MG2 domain; Region: A2M_N; pfam01835
196162005395	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
196162005396	PGAP1-like protein; Region: PGAP1; pfam07819
196162005397	acyl-CoA esterase; Provisional; Region: PRK10673
196162005398	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
196162005399	CGNR zinc finger; Region: zf-CGNR; pfam11706
196162005400	Domain of unknown function DUF20; Region: UPF0118; pfam01594
196162005401	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
196162005402	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162005403	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
196162005404	NAD(P) binding site [chemical binding]; other site
196162005405	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
196162005406	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162005407	dimer interface [polypeptide binding]; other site
196162005408	substrate binding site [chemical binding]; other site
196162005409	metal binding site [ion binding]; metal-binding site
196162005410	putative acyltransferase; Provisional; Region: PRK05790
196162005411	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162005412	dimer interface [polypeptide binding]; other site
196162005413	active site
196162005414	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
196162005415	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
196162005416	Walker A; other site
196162005417	Bacterial PH domain; Region: DUF304; pfam03703
196162005418	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162005419	MarR family; Region: MarR; pfam01047
196162005420	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
196162005421	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
196162005422	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
196162005423	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
196162005424	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162005425	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196162005426	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
196162005427	nudix motif; other site
196162005428	glycogen branching enzyme; Provisional; Region: PRK05402
196162005429	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
196162005430	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
196162005431	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
196162005432	active site
196162005433	catalytic site [active]
196162005434	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
196162005435	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
196162005436	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
196162005437	trehalose synthase; Region: treS_nterm; TIGR02456
196162005438	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
196162005439	active site
196162005440	catalytic site [active]
196162005441	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
196162005442	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
196162005443	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
196162005444	active site
196162005445	catalytic site [active]
196162005446	Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128
196162005447	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
196162005448	Zn binding site [ion binding]; other site
196162005449	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
196162005450	putative homodimer interface [polypeptide binding]; other site
196162005451	putative active site pocket [active]
196162005452	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
196162005453	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
196162005454	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
196162005455	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
196162005456	active site
196162005457	catalytic site [active]
196162005458	enoyl-CoA hydratase; Provisional; Region: PRK05862
196162005459	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162005460	substrate binding site [chemical binding]; other site
196162005461	oxyanion hole (OAH) forming residues; other site
196162005462	trimer interface [polypeptide binding]; other site
196162005463	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
196162005464	Ligand binding site [chemical binding]; other site
196162005465	Electron transfer flavoprotein domain; Region: ETF; pfam01012
196162005466	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
196162005467	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
196162005468	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
196162005469	Lysyl oxidase; Region: Lysyl_oxidase; pfam01186
196162005470	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
196162005471	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
196162005472	putative catalytic cysteine [active]
196162005473	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
196162005474	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
196162005475	active site
196162005476	(T/H)XGH motif; other site
196162005477	Oligomerisation domain; Region: Oligomerisation; pfam02410
196162005478	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162005479	catalytic core [active]
196162005480	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162005481	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162005482	PilZ domain; Region: PilZ; pfam07238
196162005483	Tumour suppressor p53-binding protein-1 Tudor; Region: 53-BP1_Tudor; pfam09038
196162005484	Helix-turn-helix domain; Region: HTH_18; pfam12833
196162005485	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
196162005486	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162005487	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162005488	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
196162005489	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162005490	dimer interface [polypeptide binding]; other site
196162005491	active site
196162005492	classical (c) SDRs; Region: SDR_c; cd05233
196162005493	NAD(P) binding site [chemical binding]; other site
196162005494	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
196162005495	active site
196162005496	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
196162005497	putative active site [active]
196162005498	ATP binding site [chemical binding]; other site
196162005499	putative substrate binding site [chemical binding]; other site
196162005500	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162005501	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162005502	active site
196162005503	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162005504	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162005505	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
196162005506	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162005507	NAD(P) binding site [chemical binding]; other site
196162005508	active site
196162005509	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
196162005510	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
196162005511	dimer interface [polypeptide binding]; other site
196162005512	PYR/PP interface [polypeptide binding]; other site
196162005513	TPP binding site [chemical binding]; other site
196162005514	substrate binding site [chemical binding]; other site
196162005515	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
196162005516	metal binding site [ion binding]; metal-binding site
196162005517	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
196162005518	TPP-binding site; other site
196162005519	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
196162005520	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
196162005521	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162005522	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162005523	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162005524	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162005525	TM-ABC transporter signature motif; other site
196162005526	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162005527	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162005528	TM-ABC transporter signature motif; other site
196162005529	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162005530	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162005531	Walker A/P-loop; other site
196162005532	ATP binding site [chemical binding]; other site
196162005533	Q-loop/lid; other site
196162005534	ABC transporter signature motif; other site
196162005535	Walker B; other site
196162005536	D-loop; other site
196162005537	H-loop/switch region; other site
196162005538	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162005539	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162005540	Walker A/P-loop; other site
196162005541	ATP binding site [chemical binding]; other site
196162005542	Q-loop/lid; other site
196162005543	ABC transporter signature motif; other site
196162005544	Walker B; other site
196162005545	D-loop; other site
196162005546	H-loop/switch region; other site
196162005547	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
196162005548	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162005549	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
196162005550	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
196162005551	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196162005552	phosphate binding site [ion binding]; other site
196162005553	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162005554	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
196162005555	homotrimer interaction site [polypeptide binding]; other site
196162005556	putative active site [active]
196162005557	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
196162005558	classical (c) SDRs; Region: SDR_c; cd05233
196162005559	NAD(P) binding site [chemical binding]; other site
196162005560	active site
196162005561	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196162005562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162005563	NAD(P) binding site [chemical binding]; other site
196162005564	active site
196162005565	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162005566	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162005567	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
196162005568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162005569	NAD(P) binding site [chemical binding]; other site
196162005570	active site
196162005571	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
196162005572	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
196162005573	Predicted oxidoreductase [General function prediction only]; Region: COG3573
196162005574	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162005575	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162005576	NAD(P) binding site [chemical binding]; other site
196162005577	active site
196162005578	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162005579	active site
196162005580	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
196162005581	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
196162005582	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
196162005583	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196162005584	FMN binding site [chemical binding]; other site
196162005585	substrate binding site [chemical binding]; other site
196162005586	putative catalytic residue [active]
196162005587	enoyl-CoA hydratase; Provisional; Region: PRK08260
196162005588	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162005589	substrate binding site [chemical binding]; other site
196162005590	oxyanion hole (OAH) forming residues; other site
196162005591	trimer interface [polypeptide binding]; other site
196162005592	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196162005593	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162005594	NAD(P) binding site [chemical binding]; other site
196162005595	active site
196162005596	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
196162005597	EamA-like transporter family; Region: EamA; pfam00892
196162005598	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162005599	active site
196162005600	metal binding site [ion binding]; metal-binding site
196162005601	Amino acid permease; Region: AA_permease_2; pfam13520
196162005602	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
196162005603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162005604	dimer interface [polypeptide binding]; other site
196162005605	phosphorylation site [posttranslational modification]
196162005606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005607	ATP binding site [chemical binding]; other site
196162005608	Mg2+ binding site [ion binding]; other site
196162005609	G-X-G motif; other site
196162005610	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
196162005611	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162005612	active site
196162005613	phosphorylation site [posttranslational modification]
196162005614	intermolecular recognition site; other site
196162005615	dimerization interface [polypeptide binding]; other site
196162005616	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162005617	DNA binding site [nucleotide binding]
196162005618	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
196162005619	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
196162005620	Thioredoxin; Region: Thioredoxin_4; pfam13462
196162005621	Predicted acetyltransferase [General function prediction only]; Region: COG2388
196162005622	Uncharacterized conserved protein [Function unknown]; Region: COG2353
196162005623	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196162005624	MarR family; Region: MarR_2; pfam12802
196162005625	MarR family; Region: MarR_2; cl17246
196162005626	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162005627	Cytochrome P450; Region: p450; cl12078
196162005628	glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040
196162005629	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
196162005630	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
196162005631	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162005632	FeS/SAM binding site; other site
196162005633	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
196162005634	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
196162005635	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
196162005636	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
196162005637	Protein of unknown function (DUF419); Region: DUF419; pfam04237
196162005638	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
196162005639	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162005640	motif II; other site
196162005641	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196162005642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
196162005643	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
196162005644	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
196162005645	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
196162005646	HIGH motif; other site
196162005647	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
196162005648	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162005649	active site
196162005650	KMSKS motif; other site
196162005651	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
196162005652	tRNA binding surface [nucleotide binding]; other site
196162005653	EDD domain protein, DegV family; Region: DegV; TIGR00762
196162005654	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
196162005655	SLBB domain; Region: SLBB; pfam10531
196162005656	comEA protein; Region: comE; TIGR01259
196162005657	Helix-hairpin-helix motif; Region: HHH; pfam00633
196162005658	Competence protein; Region: Competence; pfam03772
196162005659	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
196162005660	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162005661	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
196162005662	hypothetical protein; Reviewed; Region: PRK07914
196162005663	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
196162005664	Phosphotransferase enzyme family; Region: APH; pfam01636
196162005665	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
196162005666	active site
196162005667	ATP binding site [chemical binding]; other site
196162005668	GTP-binding protein LepA; Provisional; Region: PRK05433
196162005669	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
196162005670	G1 box; other site
196162005671	putative GEF interaction site [polypeptide binding]; other site
196162005672	GTP/Mg2+ binding site [chemical binding]; other site
196162005673	Switch I region; other site
196162005674	G2 box; other site
196162005675	G3 box; other site
196162005676	Switch II region; other site
196162005677	G4 box; other site
196162005678	G5 box; other site
196162005679	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
196162005680	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
196162005681	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
196162005682	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655
196162005683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
196162005684	MOSC domain; Region: MOSC; pfam03473
196162005685	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
196162005686	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
196162005687	acyl-activating enzyme (AAE) consensus motif; other site
196162005688	putative AMP binding site [chemical binding]; other site
196162005689	putative active site [active]
196162005690	putative CoA binding site [chemical binding]; other site
196162005691	Short chain fatty acid transporter; Region: SCFA_trans; cl17380
196162005692	DNA Polymerase Y-family; Region: PolY_like; cd03468
196162005693	active site
196162005694	DNA binding site [nucleotide binding]
196162005695	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
196162005696	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
196162005697	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
196162005698	active site
196162005699	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
196162005700	generic binding surface I; other site
196162005701	generic binding surface II; other site
196162005702	coproporphyrinogen III oxidase; Validated; Region: PRK05628
196162005703	TM2 domain; Region: TM2; pfam05154
196162005704	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
196162005705	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162005706	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
196162005707	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
196162005708	chaperone protein DnaJ; Provisional; Region: PRK14278
196162005709	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
196162005710	HSP70 interaction site [polypeptide binding]; other site
196162005711	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
196162005712	Zn binding sites [ion binding]; other site
196162005713	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
196162005714	dimer interface [polypeptide binding]; other site
196162005715	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
196162005716	RNA methyltransferase, RsmE family; Region: TIGR00046
196162005717	Sporulation and spore germination; Region: Germane; pfam10646
196162005718	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
196162005719	Sporulation and spore germination; Region: Germane; pfam10646
196162005720	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
196162005721	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
196162005722	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162005723	DNA binding residues [nucleotide binding]
196162005724	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
196162005725	nucleotide binding site/active site [active]
196162005726	HIT family signature motif; other site
196162005727	catalytic residue [active]
196162005728	Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082
196162005729	Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712
196162005730	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
196162005731	PhoH-like protein; Region: PhoH; pfam02562
196162005732	metal-binding heat shock protein; Provisional; Region: PRK00016
196162005733	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196162005734	Domain of unknown function DUF21; Region: DUF21; pfam01595
196162005735	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196162005736	Transporter associated domain; Region: CorC_HlyC; smart01091
196162005737	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162005738	FAD binding domain; Region: FAD_binding_4; pfam01565
196162005739	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
196162005740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162005741	S-adenosylmethionine binding site [chemical binding]; other site
196162005742	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
196162005743	FAD binding pocket [chemical binding]; other site
196162005744	FAD binding motif [chemical binding]; other site
196162005745	phosphate binding motif [ion binding]; other site
196162005746	NAD binding pocket [chemical binding]; other site
196162005747	GTPase Era; Reviewed; Region: era; PRK00089
196162005748	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
196162005749	G1 box; other site
196162005750	GTP/Mg2+ binding site [chemical binding]; other site
196162005751	Switch I region; other site
196162005752	G2 box; other site
196162005753	Switch II region; other site
196162005754	G3 box; other site
196162005755	G4 box; other site
196162005756	G5 box; other site
196162005757	KH domain; Region: KH_2; pfam07650
196162005758	SnoaL-like domain; Region: SnoaL_2; pfam12680
196162005759	Septum formation; Region: Septum_form; pfam13845
196162005760	Septum formation; Region: Septum_form; pfam13845
196162005761	Septum formation; Region: Septum_form; pfam13845
196162005762	Septum formation; Region: Septum_form; pfam13845
196162005763	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
196162005764	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
196162005765	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196162005766	Mg2+ binding site [ion binding]; other site
196162005767	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
196162005768	anti sigma factor interaction site; other site
196162005769	regulatory phosphorylation site [posttranslational modification]; other site
196162005770	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
196162005771	GAF domain; Region: GAF; pfam01590
196162005772	ANTAR domain; Region: ANTAR; pfam03861
196162005773	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
196162005774	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162005775	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162005776	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162005777	DNA binding residues [nucleotide binding]
196162005778	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
196162005779	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162005780	NAD binding site [chemical binding]; other site
196162005781	catalytic Zn binding site [ion binding]; other site
196162005782	structural Zn binding site [ion binding]; other site
196162005783	2-isopropylmalate synthase; Validated; Region: PRK03739
196162005784	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
196162005785	active site
196162005786	catalytic residues [active]
196162005787	metal binding site [ion binding]; metal-binding site
196162005788	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
196162005789	MASE1; Region: MASE1; pfam05231
196162005790	PAS domain S-box; Region: sensory_box; TIGR00229
196162005791	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162005792	PAS domain; Region: PAS_9; pfam13426
196162005793	putative active site [active]
196162005794	heme pocket [chemical binding]; other site
196162005795	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
196162005796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162005797	putative active site [active]
196162005798	heme pocket [chemical binding]; other site
196162005799	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162005800	dimer interface [polypeptide binding]; other site
196162005801	phosphorylation site [posttranslational modification]
196162005802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005803	ATP binding site [chemical binding]; other site
196162005804	Mg2+ binding site [ion binding]; other site
196162005805	G-X-G motif; other site
196162005806	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162005807	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
196162005808	Recombination protein O N terminal; Region: RecO_N; pfam11967
196162005809	Recombination protein O C terminal; Region: RecO_C; pfam02565
196162005810	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162005811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162005812	dimer interface [polypeptide binding]; other site
196162005813	phosphorylation site [posttranslational modification]
196162005814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005815	ATP binding site [chemical binding]; other site
196162005816	Mg2+ binding site [ion binding]; other site
196162005817	G-X-G motif; other site
196162005818	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
196162005819	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
196162005820	catalytic residue [active]
196162005821	putative FPP diphosphate  binding site; other site
196162005822	putative FPP binding hydrophobic cleft; other site
196162005823	dimer interface [polypeptide binding]; other site
196162005824	putative IPP diphosphate binding site; other site
196162005825	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
196162005826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162005827	dimer interface [polypeptide binding]; other site
196162005828	phosphorylation site [posttranslational modification]
196162005829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005830	ATP binding site [chemical binding]; other site
196162005831	Mg2+ binding site [ion binding]; other site
196162005832	G-X-G motif; other site
196162005833	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
196162005834	metal binding site 2 [ion binding]; metal-binding site
196162005835	putative DNA binding helix; other site
196162005836	metal binding site 1 [ion binding]; metal-binding site
196162005837	dimer interface [polypeptide binding]; other site
196162005838	structural Zn2+ binding site [ion binding]; other site
196162005839	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
196162005840	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
196162005841	ABC-ATPase subunit  interface; other site
196162005842	dimer interface [polypeptide binding]; other site
196162005843	putative PBP binding regions; other site
196162005844	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
196162005845	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
196162005846	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
196162005847	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
196162005848	intersubunit interface [polypeptide binding]; other site
196162005849	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
196162005850	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
196162005851	glycyl-tRNA synthetase; Provisional; Region: PRK04173
196162005852	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196162005853	motif 1; other site
196162005854	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
196162005855	active site
196162005856	motif 2; other site
196162005857	motif 3; other site
196162005858	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
196162005859	anticodon binding site; other site
196162005860	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
196162005861	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
196162005862	FMN binding site [chemical binding]; other site
196162005863	active site
196162005864	catalytic residues [active]
196162005865	substrate binding site [chemical binding]; other site
196162005866	HEAT repeats; Region: HEAT_2; pfam13646
196162005867	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
196162005868	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196162005869	Zn2+ binding site [ion binding]; other site
196162005870	Mg2+ binding site [ion binding]; other site
196162005871	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
196162005872	glycerate dehydrogenase; Provisional; Region: PRK06487
196162005873	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166
196162005874	putative ligand binding site [chemical binding]; other site
196162005875	putative NAD binding site [chemical binding]; other site
196162005876	catalytic site [active]
196162005877	CHC2 zinc finger; Region: zf-CHC2; cl17510
196162005878	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
196162005879	protein-splicing catalytic site; other site
196162005880	thioester formation/cholesterol transfer; other site
196162005881	CHC2 zinc finger; Region: zf-CHC2; cl17510
196162005882	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
196162005883	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
196162005884	active site
196162005885	metal binding site [ion binding]; metal-binding site
196162005886	interdomain interaction site; other site
196162005887	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
196162005888	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
196162005889	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196162005890	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
196162005891	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162005892	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162005893	Walker A/P-loop; other site
196162005894	ATP binding site [chemical binding]; other site
196162005895	Q-loop/lid; other site
196162005896	ABC transporter signature motif; other site
196162005897	Walker B; other site
196162005898	D-loop; other site
196162005899	H-loop/switch region; other site
196162005900	CcmB protein; Region: CcmB; cl17444
196162005901	tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791
196162005902	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
196162005903	CcmE; Region: CcmE; pfam03100
196162005904	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
196162005905	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
196162005906	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162005907	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162005908	catalytic residues [active]
196162005909	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
196162005910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
196162005911	binding surface
196162005912	TPR motif; other site
196162005913	TPR repeat; Region: TPR_11; pfam13414
196162005914	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
196162005915	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
196162005916	NAD(P) binding pocket [chemical binding]; other site
196162005917	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
196162005918	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
196162005919	Protein of unknown function DUF72; Region: DUF72; pfam01904
196162005920	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
196162005921	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
196162005922	Int/Topo IB signature motif; other site
196162005923	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
196162005924	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
196162005925	dimer interface [polypeptide binding]; other site
196162005926	putative CheW interface [polypeptide binding]; other site
196162005927	PAS domain S-box; Region: sensory_box; TIGR00229
196162005928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162005929	putative active site [active]
196162005930	heme pocket [chemical binding]; other site
196162005931	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162005932	putative active site [active]
196162005933	PAS fold; Region: PAS_3; pfam08447
196162005934	heme pocket [chemical binding]; other site
196162005935	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162005936	dimer interface [polypeptide binding]; other site
196162005937	phosphorylation site [posttranslational modification]
196162005938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162005939	ATP binding site [chemical binding]; other site
196162005940	Mg2+ binding site [ion binding]; other site
196162005941	G-X-G motif; other site
196162005942	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
196162005943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162005944	active site
196162005945	phosphorylation site [posttranslational modification]
196162005946	intermolecular recognition site; other site
196162005947	dimerization interface [polypeptide binding]; other site
196162005948	Response regulator receiver domain; Region: Response_reg; pfam00072
196162005949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162005950	active site
196162005951	phosphorylation site [posttranslational modification]
196162005952	intermolecular recognition site; other site
196162005953	dimerization interface [polypeptide binding]; other site
196162005954	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
196162005955	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
196162005956	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162005957	active site
196162005958	ATP binding site [chemical binding]; other site
196162005959	substrate binding site [chemical binding]; other site
196162005960	activation loop (A-loop); other site
196162005961	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
196162005962	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
196162005963	active site
196162005964	HIGH motif; other site
196162005965	dimer interface [polypeptide binding]; other site
196162005966	KMSKS motif; other site
196162005967	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196162005968	RNA binding surface [nucleotide binding]; other site
196162005969	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
196162005970	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
196162005971	active site
196162005972	substrate binding site [chemical binding]; other site
196162005973	FMN binding site [chemical binding]; other site
196162005974	putative catalytic residues [active]
196162005975	translation initiation factor IF-2; Validated; Region: infB; PRK05306
196162005976	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
196162005977	active site
196162005978	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162005979	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
196162005980	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
196162005981	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196162005982	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
196162005983	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
196162005984	dimer interface [polypeptide binding]; other site
196162005985	active site
196162005986	acyl carrier protein; Provisional; Region: acpP; PRK00982
196162005987	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
196162005988	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
196162005989	dimer interface [polypeptide binding]; other site
196162005990	active site
196162005991	CoA binding pocket [chemical binding]; other site
196162005992	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
196162005993	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
196162005994	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
196162005995	lipoyl-biotinyl attachment site [posttranslational modification]; other site
196162005996	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162005997	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162005998	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196162005999	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162006000	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
196162006001	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
196162006002	dimer interface [polypeptide binding]; other site
196162006003	TPP-binding site [chemical binding]; other site
196162006004	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
196162006005	acyl-CoA synthetase; Validated; Region: PRK07788
196162006006	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162006007	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162006008	acyl-activating enzyme (AAE) consensus motif; other site
196162006009	AMP binding site [chemical binding]; other site
196162006010	active site
196162006011	CoA binding site [chemical binding]; other site
196162006012	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
196162006013	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
196162006014	dimer interface [polypeptide binding]; other site
196162006015	catalytic triad [active]
196162006016	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162006017	Ligand Binding Site [chemical binding]; other site
196162006018	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162006019	Ligand Binding Site [chemical binding]; other site
196162006020	fatty acyl-CoA reductase; Region: PLN02996
196162006021	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162006022	NAD(P) binding site [chemical binding]; other site
196162006023	active site
196162006024	C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071
196162006025	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
196162006026	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196162006027	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162006028	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162006029	NAD(P) binding site [chemical binding]; other site
196162006030	Domain of unknown function (DUF2088); Region: DUF2088; pfam09861
196162006031	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162006032	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196162006033	putative acyl-acceptor binding pocket; other site
196162006034	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
196162006035	Protein of unknown function (DUF461); Region: DUF461; pfam04314
196162006036	Protein kinase domain; Region: Pkinase; pfam00069
196162006037	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162006038	active site
196162006039	ATP binding site [chemical binding]; other site
196162006040	substrate binding site [chemical binding]; other site
196162006041	activation loop (A-loop); other site
196162006042	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162006043	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162006044	active site
196162006045	phosphorylation site [posttranslational modification]
196162006046	intermolecular recognition site; other site
196162006047	dimerization interface [polypeptide binding]; other site
196162006048	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162006049	DNA binding site [nucleotide binding]
196162006050	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
196162006051	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162006052	dimerization interface [polypeptide binding]; other site
196162006053	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162006054	dimer interface [polypeptide binding]; other site
196162006055	phosphorylation site [posttranslational modification]
196162006056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162006057	ATP binding site [chemical binding]; other site
196162006058	Mg2+ binding site [ion binding]; other site
196162006059	G-X-G motif; other site
196162006060	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
196162006061	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162006062	acyl-activating enzyme (AAE) consensus motif; other site
196162006063	AMP binding site [chemical binding]; other site
196162006064	active site
196162006065	CoA binding site [chemical binding]; other site
196162006066	NifU-like domain; Region: NifU; cl00484
196162006067	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
196162006068	G1 box; other site
196162006069	GTP/Mg2+ binding site [chemical binding]; other site
196162006070	G2 box; other site
196162006071	Switch I region; other site
196162006072	G3 box; other site
196162006073	Switch II region; other site
196162006074	G4 box; other site
196162006075	G5 box; other site
196162006076	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
196162006077	Nucleoside recognition; Region: Gate; pfam07670
196162006078	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
196162006079	FeoA domain; Region: FeoA; pfam04023
196162006080	Uncharacterized conserved protein [Function unknown]; Region: COG0327
196162006081	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
196162006082	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
196162006083	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
196162006084	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
196162006085	Putative zinc ribbon domain; Region: DUF164; pfam02591
196162006086	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
196162006087	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
196162006088	RNA/DNA hybrid binding site [nucleotide binding]; other site
196162006089	active site
196162006090	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162006091	catalytic core [active]
196162006092	hypothetical protein; Validated; Region: PRK02101
196162006093	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
196162006094	RNB domain; Region: RNB; pfam00773
196162006095	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
196162006096	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196162006097	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
196162006098	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162006099	AMP binding site [chemical binding]; other site
196162006100	active site
196162006101	acyl-activating enzyme (AAE) consensus motif; other site
196162006102	CoA binding site [chemical binding]; other site
196162006103	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
196162006104	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
196162006105	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162006106	Walker A/P-loop; other site
196162006107	ATP binding site [chemical binding]; other site
196162006108	Q-loop/lid; other site
196162006109	ABC transporter signature motif; other site
196162006110	Walker B; other site
196162006111	D-loop; other site
196162006112	H-loop/switch region; other site
196162006113	TOBE domain; Region: TOBE_2; pfam08402
196162006114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162006115	dimer interface [polypeptide binding]; other site
196162006116	conserved gate region; other site
196162006117	putative PBP binding loops; other site
196162006118	ABC-ATPase subunit interface; other site
196162006119	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
196162006120	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162006121	dimer interface [polypeptide binding]; other site
196162006122	conserved gate region; other site
196162006123	putative PBP binding loops; other site
196162006124	ABC-ATPase subunit interface; other site
196162006125	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
196162006126	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
196162006127	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
196162006128	Amidinotransferase; Region: Amidinotransf; pfam02274
196162006129	Integrase core domain; Region: rve_3; pfam13683
196162006130	Helix-turn-helix domain; Region: HTH_38; pfam13936
196162006131	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196162006132	Integrase core domain; Region: rve; pfam00665
196162006133	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
196162006134	Malic enzyme, N-terminal domain; Region: malic; pfam00390
196162006135	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
196162006136	putative NAD(P) binding site [chemical binding]; other site
196162006137	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
196162006138	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
196162006139	tetramer interface [polypeptide binding]; other site
196162006140	active site
196162006141	Mg2+/Mn2+ binding site [ion binding]; other site
196162006142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
196162006143	binding surface
196162006144	TPR motif; other site
196162006145	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
196162006146	active site
196162006147	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162006148	putative catalytic site [active]
196162006149	putative metal binding site [ion binding]; other site
196162006150	putative phosphate binding site [ion binding]; other site
196162006151	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
196162006152	Domain of unknown function DUF21; Region: DUF21; pfam01595
196162006153	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196162006154	Transporter associated domain; Region: CorC_HlyC; smart01091
196162006155	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
196162006156	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
196162006157	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
196162006158	oligomerization interface [polypeptide binding]; other site
196162006159	active site
196162006160	metal binding site [ion binding]; metal-binding site
196162006161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162006162	S-adenosylmethionine binding site [chemical binding]; other site
196162006163	NAD synthetase; Reviewed; Region: nadE; PRK02628
196162006164	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
196162006165	multimer interface [polypeptide binding]; other site
196162006166	active site
196162006167	catalytic triad [active]
196162006168	protein interface 1 [polypeptide binding]; other site
196162006169	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
196162006170	homodimer interface [polypeptide binding]; other site
196162006171	NAD binding pocket [chemical binding]; other site
196162006172	ATP binding pocket [chemical binding]; other site
196162006173	Mg binding site [ion binding]; other site
196162006174	active-site loop [active]
196162006175	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
196162006176	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
196162006177	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
196162006178	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
196162006179	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
196162006180	catalytic triad [active]
196162006181	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196162006182	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
196162006183	metal binding triad; other site
196162006184	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
196162006185	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196162006186	metal binding triad; other site
196162006187	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
196162006188	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162006189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162006190	active site
196162006191	phosphorylation site [posttranslational modification]
196162006192	intermolecular recognition site; other site
196162006193	dimerization interface [polypeptide binding]; other site
196162006194	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162006195	DNA binding site [nucleotide binding]
196162006196	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162006197	MarR family; Region: MarR; pfam01047
196162006198	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
196162006199	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
196162006200	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
196162006201	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162006202	putative active site [active]
196162006203	putative metal binding site [ion binding]; other site
196162006204	Predicted esterase [General function prediction only]; Region: COG0400
196162006205	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
196162006206	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
196162006207	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
196162006208	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
196162006209	NodB motif; other site
196162006210	putative active site [active]
196162006211	putative catalytic site [active]
196162006212	putative Zn binding site [ion binding]; other site
196162006213	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
196162006214	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
196162006215	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
196162006216	active site
196162006217	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196162006218	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
196162006219	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162006220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162006221	active site
196162006222	phosphorylation site [posttranslational modification]
196162006223	intermolecular recognition site; other site
196162006224	dimerization interface [polypeptide binding]; other site
196162006225	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162006226	DNA binding site [nucleotide binding]
196162006227	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
196162006228	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162006229	dimer interface [polypeptide binding]; other site
196162006230	phosphorylation site [posttranslational modification]
196162006231	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162006232	ATP binding site [chemical binding]; other site
196162006233	Mg2+ binding site [ion binding]; other site
196162006234	G-X-G motif; other site
196162006235	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
196162006236	active site
196162006237	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162006238	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196162006239	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
196162006240	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
196162006241	hypothetical protein; Provisional; Region: PRK11622
196162006242	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
196162006243	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
196162006244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162006245	dimer interface [polypeptide binding]; other site
196162006246	conserved gate region; other site
196162006247	putative PBP binding loops; other site
196162006248	ABC-ATPase subunit interface; other site
196162006249	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
196162006250	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
196162006251	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
196162006252	Walker A/P-loop; other site
196162006253	ATP binding site [chemical binding]; other site
196162006254	Q-loop/lid; other site
196162006255	ABC transporter signature motif; other site
196162006256	Walker B; other site
196162006257	D-loop; other site
196162006258	H-loop/switch region; other site
196162006259	TOBE domain; Region: TOBE_2; pfam08402
196162006260	Uncharacterized conserved protein [Function unknown]; Region: COG0398
196162006261	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
196162006262	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
196162006263	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162006264	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162006265	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162006266	Domain of unknown function (DUF427); Region: DUF427; pfam04248
196162006267	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196162006268	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162006269	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162006270	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
196162006271	catalytic residues [active]
196162006272	Isochorismatase family; Region: Isochorismatase; pfam00857
196162006273	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
196162006274	catalytic triad [active]
196162006275	conserved cis-peptide bond; other site
196162006276	Predicted permeases [General function prediction only]; Region: COG0730
196162006277	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196162006278	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162006279	Uncharacterized conserved protein [Function unknown]; Region: COG2128
196162006280	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
196162006281	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
196162006282	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
196162006283	ligand binding site [chemical binding]; other site
196162006284	flexible hinge region; other site
196162006285	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
196162006286	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
196162006287	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
196162006288	active site
196162006289	nucleophile elbow; other site
196162006290	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
196162006291	mercuric reductase; Validated; Region: PRK06370
196162006292	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162006293	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162006294	Putative zinc-finger; Region: zf-HC2; pfam13490
196162006295	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
196162006296	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162006297	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162006298	DNA binding residues [nucleotide binding]
196162006299	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
196162006300	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
196162006301	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162006302	NAD(P) binding site [chemical binding]; other site
196162006303	catalytic residues [active]
196162006304	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
196162006305	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
196162006306	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
196162006307	NAD(P) binding site [chemical binding]; other site
196162006308	catalytic residues [active]
196162006309	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
196162006310	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162006311	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
196162006312	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162006313	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162006314	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162006315	Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719
196162006316	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
196162006317	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
196162006318	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
196162006319	OsmC-like protein; Region: OsmC; cl00767
196162006320	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
196162006321	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
196162006322	dimer interface [polypeptide binding]; other site
196162006323	TPP-binding site [chemical binding]; other site
196162006324	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162006325	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162006326	putative DNA binding site [nucleotide binding]; other site
196162006327	putative Zn2+ binding site [ion binding]; other site
196162006328	Protein of unknown function (DUF664); Region: DUF664; pfam04978
196162006329	DinB superfamily; Region: DinB_2; pfam12867
196162006330	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
196162006331	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162006332	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
196162006333	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162006334	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162006335	Walker A/P-loop; other site
196162006336	ATP binding site [chemical binding]; other site
196162006337	Q-loop/lid; other site
196162006338	ABC transporter signature motif; other site
196162006339	Walker B; other site
196162006340	D-loop; other site
196162006341	H-loop/switch region; other site
196162006342	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162006343	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162006344	Walker A/P-loop; other site
196162006345	ATP binding site [chemical binding]; other site
196162006346	Q-loop/lid; other site
196162006347	ABC transporter signature motif; other site
196162006348	Walker B; other site
196162006349	D-loop; other site
196162006350	H-loop/switch region; other site
196162006351	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162006352	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162006353	TM-ABC transporter signature motif; other site
196162006354	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162006355	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162006356	TM-ABC transporter signature motif; other site
196162006357	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162006358	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
196162006359	ligand binding site [chemical binding]; other site
196162006360	YCII-related domain; Region: YCII; cl00999
196162006361	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
196162006362	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162006363	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
196162006364	DNA binding residues [nucleotide binding]
196162006365	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
196162006366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162006367	Walker A/P-loop; other site
196162006368	ATP binding site [chemical binding]; other site
196162006369	Q-loop/lid; other site
196162006370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162006371	ABC transporter signature motif; other site
196162006372	Walker B; other site
196162006373	D-loop; other site
196162006374	H-loop/switch region; other site
196162006375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162006376	Walker A/P-loop; other site
196162006377	ATP binding site [chemical binding]; other site
196162006378	Q-loop/lid; other site
196162006379	ABC transporter signature motif; other site
196162006380	Walker B; other site
196162006381	D-loop; other site
196162006382	H-loop/switch region; other site
196162006383	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
196162006384	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
196162006385	catalytic Zn binding site [ion binding]; other site
196162006386	NAD binding site [chemical binding]; other site
196162006387	structural Zn binding site [ion binding]; other site
196162006388	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
196162006389	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
196162006390	High-affinity nickel-transport protein; Region: NicO; cl00964
196162006391	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162006392	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
196162006393	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162006394	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
196162006395	Integrase core domain; Region: rve; pfam00665
196162006396	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162006397	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
196162006398	substrate binding site [chemical binding]; other site
196162006399	oxyanion hole (OAH) forming residues; other site
196162006400	trimer interface [polypeptide binding]; other site
196162006401	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
196162006402	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
196162006403	B12 binding site [chemical binding]; other site
196162006404	cobalt ligand [ion binding]; other site
196162006405	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
196162006406	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162006407	acyl-activating enzyme (AAE) consensus motif; other site
196162006408	AMP binding site [chemical binding]; other site
196162006409	active site
196162006410	CoA binding site [chemical binding]; other site
196162006411	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
196162006412	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
196162006413	Walker A; other site
196162006414	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
196162006415	G4 box; other site
196162006416	G5 box; other site
196162006417	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
196162006418	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162006419	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162006420	DNA-binding site [nucleotide binding]; DNA binding site
196162006421	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
196162006422	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162006423	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
196162006424	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162006425	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
196162006426	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162006427	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
196162006428	[2Fe-2S] cluster binding site [ion binding]; other site
196162006429	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
196162006430	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162006431	NAD(P) binding site [chemical binding]; other site
196162006432	active site
196162006433	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
196162006434	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
196162006435	[2Fe-2S] cluster binding site [ion binding]; other site
196162006436	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162006437	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
196162006438	intersubunit interface [polypeptide binding]; other site
196162006439	active site
196162006440	Zn2+ binding site [ion binding]; other site
196162006441	ketol-acid reductoisomerase; Provisional; Region: PRK05479
196162006442	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
196162006443	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
196162006444	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
196162006445	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162006446	Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359
196162006447	active site
196162006448	Fe(II) binding site [ion binding]; other site
196162006449	dimer interface [polypeptide binding]; other site
196162006450	tetramer interface [polypeptide binding]; other site
196162006451	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162006452	MarR family; Region: MarR; pfam01047
196162006453	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
196162006454	Amidohydrolase; Region: Amidohydro_2; pfam04909
196162006455	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162006456	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162006457	Walker A/P-loop; other site
196162006458	ATP binding site [chemical binding]; other site
196162006459	Q-loop/lid; other site
196162006460	ABC transporter signature motif; other site
196162006461	Walker B; other site
196162006462	D-loop; other site
196162006463	H-loop/switch region; other site
196162006464	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162006465	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162006466	TM-ABC transporter signature motif; other site
196162006467	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162006468	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162006469	Walker A/P-loop; other site
196162006470	ATP binding site [chemical binding]; other site
196162006471	Q-loop/lid; other site
196162006472	ABC transporter signature motif; other site
196162006473	Walker B; other site
196162006474	D-loop; other site
196162006475	H-loop/switch region; other site
196162006476	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162006477	TM-ABC transporter signature motif; other site
196162006478	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162006479	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162006480	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
196162006481	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
196162006482	active site
196162006483	catalytic residues [active]
196162006484	metal binding site [ion binding]; metal-binding site
196162006485	DmpG-like communication domain; Region: DmpG_comm; pfam07836
196162006486	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
196162006487	acetaldehyde dehydrogenase; Validated; Region: PRK08300
196162006488	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
196162006489	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
196162006490	Transcriptional regulator [Transcription]; Region: LysR; COG0583
196162006491	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162006492	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196162006493	dimerization interface [polypeptide binding]; other site
196162006494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
196162006495	Transposase; Region: HTH_Tnp_1; cl17663
196162006496	HTH-like domain; Region: HTH_21; pfam13276
196162006497	Integrase core domain; Region: rve; pfam00665
196162006498	Integrase core domain; Region: rve_3; pfam13683
196162006499	FAD binding domain; Region: FAD_binding_4; pfam01565
196162006500	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
196162006501	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162006502	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162006503	enoyl-CoA hydratase; Provisional; Region: PRK06144
196162006504	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162006505	substrate binding site [chemical binding]; other site
196162006506	oxyanion hole (OAH) forming residues; other site
196162006507	trimer interface [polypeptide binding]; other site
196162006508	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162006509	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162006510	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
196162006511	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
196162006512	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162006513	Magnetospirillum NAD(P)+-dependent aldehyde dehydrogenase MSR-1-like; Region: ALDH_MGR_2402; cd07108
196162006514	NAD(P) binding site [chemical binding]; other site
196162006515	catalytic residues [active]
196162006516	catalytic residues [active]
196162006517	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162006518	Cytochrome P450; Region: p450; cl12078
196162006519	Transport protein; Region: actII; TIGR00833
196162006520	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
196162006521	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
196162006522	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162006523	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
196162006524	CoenzymeA binding site [chemical binding]; other site
196162006525	subunit interaction site [polypeptide binding]; other site
196162006526	PHB binding site; other site
196162006527	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
196162006528	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
196162006529	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162006530	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162006531	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162006532	putative DNA binding site [nucleotide binding]; other site
196162006533	putative Zn2+ binding site [ion binding]; other site
196162006534	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
196162006535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162006536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162006537	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162006538	MarR family; Region: MarR_2; cl17246
196162006539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162006540	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162006541	non-specific DNA binding site [nucleotide binding]; other site
196162006542	salt bridge; other site
196162006543	sequence-specific DNA binding site [nucleotide binding]; other site
196162006544	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196162006545	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162006546	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196162006547	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162006548	active site
196162006549	DNA binding site [nucleotide binding]
196162006550	Int/Topo IB signature motif; other site
196162006551	Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656
196162006552	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
196162006553	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
196162006554	NADP binding site [chemical binding]; other site
196162006555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162006556	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162006557	NAD(P) binding site [chemical binding]; other site
196162006558	active site
196162006559	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196162006560	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
196162006561	putative NAD(P) binding site [chemical binding]; other site
196162006562	DoxX-like family; Region: DoxX_2; pfam13564
196162006563	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
196162006564	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
196162006565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162006566	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
196162006567	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162006568	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196162006569	synthetase active site [active]
196162006570	NTP binding site [chemical binding]; other site
196162006571	metal binding site [ion binding]; metal-binding site
196162006572	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
196162006573	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162006574	NAD binding site [chemical binding]; other site
196162006575	substrate binding site [chemical binding]; other site
196162006576	putative active site [active]
196162006577	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196162006578	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162006579	DoxX-like family; Region: DoxX_2; pfam13564
196162006580	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162006581	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162006582	S-adenosylmethionine binding site [chemical binding]; other site
196162006583	NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234
196162006584	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162006585	DNA binding site [nucleotide binding]
196162006586	active site
196162006587	Int/Topo IB signature motif; other site
196162006588	Alkylmercury lyase; Region: MerB; pfam03243
196162006589	Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783
196162006590	DNA binding residues [nucleotide binding]
196162006591	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
196162006592	dimer interface [polypeptide binding]; other site
196162006593	mercury binding site [ion binding]; other site
196162006594	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196162006595	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
196162006596	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
196162006597	ResB-like family; Region: ResB; pfam05140
196162006598	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
196162006599	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162006600	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162006601	catalytic residues [active]
196162006602	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162006603	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
196162006604	catalytic residues [active]
196162006605	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
196162006606	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
196162006607	putative active site [active]
196162006608	catalytic triad [active]
196162006609	putative dimer interface [polypeptide binding]; other site
196162006610	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
196162006611	Cadmium resistance transporter; Region: Cad; pfam03596
196162006612	lipoprotein signal peptidase; Provisional; Region: PRK14769
196162006613	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
196162006614	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162006615	Soluble P-type ATPase [General function prediction only]; Region: COG4087
196162006616	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162006617	dimerization interface [polypeptide binding]; other site
196162006618	putative DNA binding site [nucleotide binding]; other site
196162006619	putative Zn2+ binding site [ion binding]; other site
196162006620	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162006621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162006622	S-adenosylmethionine binding site [chemical binding]; other site
196162006623	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196162006624	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162006625	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162006626	Walker A/P-loop; other site
196162006627	ATP binding site [chemical binding]; other site
196162006628	Q-loop/lid; other site
196162006629	ABC transporter signature motif; other site
196162006630	Walker B; other site
196162006631	D-loop; other site
196162006632	H-loop/switch region; other site
196162006633	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
196162006634	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
196162006635	Domain of unknown function (DUF305); Region: DUF305; pfam03713
196162006636	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
196162006637	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162006638	dimerization interface [polypeptide binding]; other site
196162006639	putative DNA binding site [nucleotide binding]; other site
196162006640	putative Zn2+ binding site [ion binding]; other site
196162006641	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
196162006642	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196162006643	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162006644	non-specific DNA binding site [nucleotide binding]; other site
196162006645	salt bridge; other site
196162006646	sequence-specific DNA binding site [nucleotide binding]; other site
196162006647	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162006648	non-specific DNA binding site [nucleotide binding]; other site
196162006649	salt bridge; other site
196162006650	sequence-specific DNA binding site [nucleotide binding]; other site
196162006651	Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261
196162006652	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
196162006653	AAA domain; Region: AAA_31; pfam13614
196162006654	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196162006655	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
196162006656	Walker A motif; other site
196162006657	ATP binding site [chemical binding]; other site
196162006658	Walker B motif; other site
196162006659	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196162006660	TadE-like protein; Region: TadE; pfam07811
196162006661	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162006662	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162006663	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162006664	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
196162006665	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162006666	AAA-like domain; Region: AAA_10; pfam12846
196162006667	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162006668	putative catalytic site [active]
196162006669	putative metal binding site [ion binding]; other site
196162006670	putative phosphate binding site [ion binding]; other site
196162006671	Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372
196162006672	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162006673	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162006674	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
196162006675	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
196162006676	Peptidase family M48; Region: Peptidase_M48; cl12018
196162006677	TrwC relaxase; Region: TrwC; pfam08751
196162006678	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
196162006679	AAA domain; Region: AAA_30; pfam13604
196162006680	Family description; Region: UvrD_C_2; pfam13538
196162006681	DNA primase; Validated; Region: dnaG; PRK05667
196162006682	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
196162006683	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
196162006684	active site
196162006685	metal binding site [ion binding]; metal-binding site
196162006686	interdomain interaction site; other site
196162006687	Domain of unknown function (DUF932); Region: DUF932; pfam06067
196162006688	ParB-like nuclease domain; Region: ParBc; pfam02195
196162006689	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
196162006690	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196162006691	dimer interface [polypeptide binding]; other site
196162006692	ssDNA binding site [nucleotide binding]; other site
196162006693	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196162006694	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162006695	DNA binding site [nucleotide binding]
196162006696	Int/Topo IB signature motif; other site
196162006697	active site
196162006698	catalytic residues [active]
196162006699	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196162006700	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
196162006701	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162006702	active site
196162006703	catalytic residues [active]
196162006704	DNA binding site [nucleotide binding]
196162006705	Int/Topo IB signature motif; other site
196162006706	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
196162006707	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
196162006708	DNA protecting protein DprA; Region: dprA; TIGR00732
196162006709	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
196162006710	active site
196162006711	DNA binding site [nucleotide binding]
196162006712	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
196162006713	DNA binding site [nucleotide binding]
196162006714	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
196162006715	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162006716	DNA binding residues [nucleotide binding]
196162006717	Restriction endonuclease; Region: Mrr_cat; pfam04471
196162006718	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196162006719	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162006720	ATP binding site [chemical binding]; other site
196162006721	putative Mg++ binding site [ion binding]; other site
196162006722	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162006723	nucleotide binding region [chemical binding]; other site
196162006724	ATP-binding site [chemical binding]; other site
196162006725	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196162006726	ATP binding site [chemical binding]; other site
196162006727	Mg2+ binding site [ion binding]; other site
196162006728	G-X-G motif; other site
196162006729	Type II restriction endonuclease (RE_Alw26IDE); Region: RE_Alw26IDE; pfam09665
196162006730	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
196162006731	additional DNA contacts [nucleotide binding]; other site
196162006732	mismatch recognition site; other site
196162006733	active site
196162006734	zinc binding site [ion binding]; other site
196162006735	DNA intercalation site [nucleotide binding]; other site
196162006736	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
196162006737	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
196162006738	cofactor binding site; other site
196162006739	DNA binding site [nucleotide binding]
196162006740	substrate interaction site [chemical binding]; other site
196162006741	AAA ATPase domain; Region: AAA_16; pfam13191
196162006742	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
196162006743	Walker A motif; other site
196162006744	ATP binding site [chemical binding]; other site
196162006745	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
196162006746	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162006747	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162006748	active site
196162006749	DNA binding site [nucleotide binding]
196162006750	Int/Topo IB signature motif; other site
196162006751	Helix-turn-helix domain; Region: HTH_17; pfam12728
196162006752	glutamine synthetase, type I; Region: GlnA; TIGR00653
196162006753	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
196162006754	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
196162006755	RDD family; Region: RDD; pfam06271
196162006756	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
196162006757	lipoyl synthase; Provisional; Region: PRK05481
196162006758	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162006759	FeS/SAM binding site; other site
196162006760	lipoate-protein ligase B; Provisional; Region: PRK14345
196162006761	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162006762	TIGR01777 family protein; Region: yfcH
196162006763	NAD(P) binding site [chemical binding]; other site
196162006764	active site
196162006765	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196162006766	E3 interaction surface; other site
196162006767	lipoyl attachment site [posttranslational modification]; other site
196162006768	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196162006769	E3 interaction surface; other site
196162006770	lipoyl attachment site [posttranslational modification]; other site
196162006771	e3 binding domain; Region: E3_binding; pfam02817
196162006772	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
196162006773	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
196162006774	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
196162006775	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162006776	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162006777	multifunctional aminopeptidase A; Provisional; Region: PRK00913
196162006778	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
196162006779	interface (dimer of trimers) [polypeptide binding]; other site
196162006780	Substrate-binding/catalytic site; other site
196162006781	Zn-binding sites [ion binding]; other site
196162006782	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
196162006783	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
196162006784	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
196162006785	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
196162006786	thymidylate synthase; Reviewed; Region: thyA; PRK01827
196162006787	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
196162006788	dimerization interface [polypeptide binding]; other site
196162006789	active site
196162006790	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
196162006791	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
196162006792	folate binding site [chemical binding]; other site
196162006793	NADP+ binding site [chemical binding]; other site
196162006794	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
196162006795	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162006796	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
196162006797	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
196162006798	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
196162006799	dimer interface [polypeptide binding]; other site
196162006800	active site
196162006801	catalytic residue [active]
196162006802	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
196162006803	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
196162006804	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
196162006805	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
196162006806	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
196162006807	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
196162006808	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
196162006809	Helix-turn-helix domain; Region: HTH_25; pfam13413
196162006810	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
196162006811	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
196162006812	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
196162006813	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
196162006814	FeS/SAM binding site; other site
196162006815	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
196162006816	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
196162006817	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196162006818	active site
196162006819	metal binding site [ion binding]; metal-binding site
196162006820	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
196162006821	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
196162006822	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
196162006823	generic binding surface I; other site
196162006824	generic binding surface II; other site
196162006825	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
196162006826	putative active site [active]
196162006827	putative catalytic site [active]
196162006828	putative Mg binding site IVb [ion binding]; other site
196162006829	putative phosphate binding site [ion binding]; other site
196162006830	putative DNA binding site [nucleotide binding]; other site
196162006831	putative Mg binding site IVa [ion binding]; other site
196162006832	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
196162006833	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196162006834	Competence-damaged protein; Region: CinA; pfam02464
196162006835	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
196162006836	sequence-specific DNA binding site [nucleotide binding]; other site
196162006837	salt bridge; other site
196162006838	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
196162006839	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
196162006840	putative DNA binding site [nucleotide binding]; other site
196162006841	catalytic residue [active]
196162006842	putative H2TH interface [polypeptide binding]; other site
196162006843	putative catalytic residues [active]
196162006844	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196162006845	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
196162006846	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162006847	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
196162006848	ATP binding site [chemical binding]; other site
196162006849	putative Mg++ binding site [ion binding]; other site
196162006850	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162006851	nucleotide binding region [chemical binding]; other site
196162006852	ATP-binding site [chemical binding]; other site
196162006853	DEAD/H associated; Region: DEAD_assoc; pfam08494
196162006854	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
196162006855	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162006856	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162006857	hypothetical protein; Provisional; Region: PRK01346
196162006858	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162006859	Coenzyme A binding pocket [chemical binding]; other site
196162006860	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
196162006861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
196162006862	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
196162006863	homotrimer interaction site [polypeptide binding]; other site
196162006864	putative active site [active]
196162006865	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
196162006866	DinB superfamily; Region: DinB_2; pfam12867
196162006867	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162006868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162006869	S-adenosylmethionine binding site [chemical binding]; other site
196162006870	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
196162006871	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162006872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162006873	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
196162006874	recombinase A; Provisional; Region: recA; PRK09354
196162006875	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
196162006876	hexamer interface [polypeptide binding]; other site
196162006877	Walker A motif; other site
196162006878	ATP binding site [chemical binding]; other site
196162006879	Walker B motif; other site
196162006880	recombination regulator RecX; Reviewed; Region: recX; PRK00117
196162006881	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
196162006882	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162006883	active site
196162006884	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
196162006885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162006886	Coenzyme A binding pocket [chemical binding]; other site
196162006887	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
196162006888	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
196162006889	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
196162006890	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
196162006891	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
196162006892	putative active site [active]
196162006893	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
196162006894	putative active site [active]
196162006895	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
196162006896	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196162006897	Active Sites [active]
196162006898	primosome assembly protein PriA; Validated; Region: PRK05580
196162006899	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
196162006900	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196162006901	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196162006902	serine hydroxymethyltransferase; Provisional; Region: PRK13580
196162006903	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
196162006904	dimer interface [polypeptide binding]; other site
196162006905	active site
196162006906	glycine-pyridoxal phosphate binding site [chemical binding]; other site
196162006907	folate binding site [chemical binding]; other site
196162006908	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
196162006909	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162006910	active site
196162006911	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
196162006912	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
196162006913	TrkA-N domain; Region: TrkA_N; pfam02254
196162006914	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
196162006915	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162006916	putative active site [active]
196162006917	heme pocket [chemical binding]; other site
196162006918	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162006919	dimer interface [polypeptide binding]; other site
196162006920	phosphorylation site [posttranslational modification]
196162006921	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162006922	ATP binding site [chemical binding]; other site
196162006923	Mg2+ binding site [ion binding]; other site
196162006924	G-X-G motif; other site
196162006925	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
196162006926	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162006927	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
196162006928	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
196162006929	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
196162006930	TPP-binding site [chemical binding]; other site
196162006931	putative dimer interface [polypeptide binding]; other site
196162006932	pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367
196162006933	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
196162006934	dimer interface [polypeptide binding]; other site
196162006935	PYR/PP interface [polypeptide binding]; other site
196162006936	TPP binding site [chemical binding]; other site
196162006937	substrate binding site [chemical binding]; other site
196162006938	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
196162006939	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
196162006940	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
196162006941	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
196162006942	NAD binding site [chemical binding]; other site
196162006943	substrate binding site [chemical binding]; other site
196162006944	catalytic Zn binding site [ion binding]; other site
196162006945	structural Zn binding site [ion binding]; other site
196162006946	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196162006947	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162006948	non-specific DNA binding site [nucleotide binding]; other site
196162006949	salt bridge; other site
196162006950	sequence-specific DNA binding site [nucleotide binding]; other site
196162006951	HipA-like N-terminal domain; Region: HipA_N; pfam07805
196162006952	HipA-like C-terminal domain; Region: HipA_C; pfam07804
196162006953	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162006954	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
196162006955	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162006956	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
196162006957	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
196162006958	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162006959	catalytic residue [active]
196162006960	Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686
196162006961	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
196162006962	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
196162006963	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
196162006964	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
196162006965	active site
196162006966	dimer interface [polypeptide binding]; other site
196162006967	motif 1; other site
196162006968	motif 2; other site
196162006969	motif 3; other site
196162006970	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
196162006971	anticodon binding site; other site
196162006972	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
196162006973	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162006974	Coenzyme A binding pocket [chemical binding]; other site
196162006975	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
196162006976	nucleotide binding site/active site [active]
196162006977	HIT family signature motif; other site
196162006978	catalytic residue [active]
196162006979	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
196162006980	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196162006981	active site
196162006982	xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631
196162006983	xylose isomerase; Provisional; Region: PRK12677
196162006984	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
196162006985	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
196162006986	putative ligand binding site [chemical binding]; other site
196162006987	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162006988	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162006989	Walker A/P-loop; other site
196162006990	ATP binding site [chemical binding]; other site
196162006991	Q-loop/lid; other site
196162006992	ABC transporter signature motif; other site
196162006993	Walker B; other site
196162006994	D-loop; other site
196162006995	H-loop/switch region; other site
196162006996	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162006997	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162006998	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162006999	TM-ABC transporter signature motif; other site
196162007000	MarR family; Region: MarR_2; pfam12802
196162007001	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162007002	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162007003	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
196162007004	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
196162007005	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
196162007006	active site
196162007007	multimer interface [polypeptide binding]; other site
196162007008	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
196162007009	predicted active site [active]
196162007010	catalytic triad [active]
196162007011	hypothetical protein; Validated; Region: PRK00110
196162007012	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
196162007013	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
196162007014	active site
196162007015	putative DNA-binding cleft [nucleotide binding]; other site
196162007016	dimer interface [polypeptide binding]; other site
196162007017	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
196162007018	RuvA N terminal domain; Region: RuvA_N; pfam01330
196162007019	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
196162007020	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162007021	Walker A motif; other site
196162007022	ATP binding site [chemical binding]; other site
196162007023	Walker B motif; other site
196162007024	arginine finger; other site
196162007025	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
196162007026	Preprotein translocase subunit; Region: YajC; pfam02699
196162007027	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
196162007028	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
196162007029	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
196162007030	Protein export membrane protein; Region: SecD_SecF; pfam02355
196162007031	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162007032	active site
196162007033	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
196162007034	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196162007035	Zn2+ binding site [ion binding]; other site
196162007036	Mg2+ binding site [ion binding]; other site
196162007037	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196162007038	synthetase active site [active]
196162007039	NTP binding site [chemical binding]; other site
196162007040	metal binding site [ion binding]; metal-binding site
196162007041	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
196162007042	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
196162007043	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
196162007044	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
196162007045	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
196162007046	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
196162007047	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
196162007048	Double zinc ribbon; Region: DZR; pfam12773
196162007049	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
196162007050	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
196162007051	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
196162007052	dimer interface [polypeptide binding]; other site
196162007053	motif 1; other site
196162007054	active site
196162007055	motif 2; other site
196162007056	motif 3; other site
196162007057	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
196162007058	anticodon binding site; other site
196162007059	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
196162007060	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
196162007061	dimer interface [polypeptide binding]; other site
196162007062	anticodon binding site; other site
196162007063	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
196162007064	homodimer interface [polypeptide binding]; other site
196162007065	motif 1; other site
196162007066	active site
196162007067	motif 2; other site
196162007068	GAD domain; Region: GAD; pfam02938
196162007069	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196162007070	active site
196162007071	motif 3; other site
196162007072	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
196162007073	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
196162007074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162007075	dimer interface [polypeptide binding]; other site
196162007076	conserved gate region; other site
196162007077	putative PBP binding loops; other site
196162007078	ABC-ATPase subunit interface; other site
196162007079	The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506
196162007080	peptide binding site [polypeptide binding]; other site
196162007081	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
196162007082	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
196162007083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162007084	dimer interface [polypeptide binding]; other site
196162007085	conserved gate region; other site
196162007086	putative PBP binding loops; other site
196162007087	ABC-ATPase subunit interface; other site
196162007088	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
196162007089	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196162007090	Walker A/P-loop; other site
196162007091	ATP binding site [chemical binding]; other site
196162007092	Q-loop/lid; other site
196162007093	ABC transporter signature motif; other site
196162007094	Walker B; other site
196162007095	D-loop; other site
196162007096	H-loop/switch region; other site
196162007097	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196162007098	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
196162007099	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196162007100	Walker A/P-loop; other site
196162007101	ATP binding site [chemical binding]; other site
196162007102	Q-loop/lid; other site
196162007103	ABC transporter signature motif; other site
196162007104	Walker B; other site
196162007105	D-loop; other site
196162007106	H-loop/switch region; other site
196162007107	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
196162007108	recombination factor protein RarA; Reviewed; Region: PRK13342
196162007109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162007110	Walker A motif; other site
196162007111	ATP binding site [chemical binding]; other site
196162007112	Walker B motif; other site
196162007113	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
196162007114	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
196162007115	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
196162007116	motif 1; other site
196162007117	active site
196162007118	motif 2; other site
196162007119	motif 3; other site
196162007120	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
196162007121	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
196162007122	YceG-like family; Region: YceG; pfam02618
196162007123	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
196162007124	dimerization interface [polypeptide binding]; other site
196162007125	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
196162007126	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
196162007127	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
196162007128	NAD(P) binding site [chemical binding]; other site
196162007129	shikimate binding site; other site
196162007130	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
196162007131	chorismate synthase; Validated; Region: PRK05382
196162007132	Tetramer interface [polypeptide binding]; other site
196162007133	active site
196162007134	FMN-binding site [chemical binding]; other site
196162007135	shikimate kinase; Reviewed; Region: aroK; PRK00131
196162007136	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
196162007137	ADP binding site [chemical binding]; other site
196162007138	magnesium binding site [ion binding]; other site
196162007139	putative shikimate binding site; other site
196162007140	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
196162007141	active site
196162007142	dimer interface [polypeptide binding]; other site
196162007143	metal binding site [ion binding]; metal-binding site
196162007144	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
196162007145	Dehydroquinase class II; Region: DHquinase_II; pfam01220
196162007146	trimer interface [polypeptide binding]; other site
196162007147	active site
196162007148	dimer interface [polypeptide binding]; other site
196162007149	Uncharacterized conserved protein [Function unknown]; Region: COG2968
196162007150	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
196162007151	elongation factor P; Validated; Region: PRK00529
196162007152	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
196162007153	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
196162007154	RNA binding site [nucleotide binding]; other site
196162007155	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
196162007156	RNA binding site [nucleotide binding]; other site
196162007157	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
196162007158	putative RNA binding site [nucleotide binding]; other site
196162007159	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
196162007160	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162007161	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162007162	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
196162007163	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
196162007164	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
196162007165	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
196162007166	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196162007167	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
196162007168	NAD(P) binding site [chemical binding]; other site
196162007169	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
196162007170	arginine deiminase; Provisional; Region: PRK01388
196162007171	ornithine carbamoyltransferase; Validated; Region: PRK02102
196162007172	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196162007173	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196162007174	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
196162007175	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
196162007176	putative substrate binding site [chemical binding]; other site
196162007177	nucleotide binding site [chemical binding]; other site
196162007178	nucleotide binding site [chemical binding]; other site
196162007179	homodimer interface [polypeptide binding]; other site
196162007180	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
196162007181	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162007182	active site
196162007183	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
196162007184	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196162007185	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196162007186	dihydroorotase; Validated; Region: pyrC; PRK09357
196162007187	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162007188	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
196162007189	active site
196162007190	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
196162007191	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
196162007192	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
196162007193	catalytic site [active]
196162007194	subunit interface [polypeptide binding]; other site
196162007195	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
196162007196	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196162007197	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162007198	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
196162007199	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196162007200	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162007201	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
196162007202	IMP binding site; other site
196162007203	dimer interface [polypeptide binding]; other site
196162007204	interdomain contacts; other site
196162007205	partial ornithine binding site; other site
196162007206	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
196162007207	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
196162007208	quinone interaction residues [chemical binding]; other site
196162007209	active site
196162007210	catalytic residues [active]
196162007211	FMN binding site [chemical binding]; other site
196162007212	substrate binding site [chemical binding]; other site
196162007213	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
196162007214	active site
196162007215	dimer interface [polypeptide binding]; other site
196162007216	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
196162007217	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
196162007218	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
196162007219	catalytic site [active]
196162007220	G-X2-G-X-G-K; other site
196162007221	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
196162007222	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
196162007223	Flavoprotein; Region: Flavoprotein; pfam02441
196162007224	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
196162007225	S-adenosylmethionine synthetase; Validated; Region: PRK05250
196162007226	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
196162007227	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
196162007228	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
196162007229	primosome assembly protein PriA; Provisional; Region: PRK14873
196162007230	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
196162007231	active site
196162007232	catalytic residues [active]
196162007233	metal binding site [ion binding]; metal-binding site
196162007234	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
196162007235	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
196162007236	putative active site [active]
196162007237	substrate binding site [chemical binding]; other site
196162007238	putative cosubstrate binding site; other site
196162007239	catalytic site [active]
196162007240	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
196162007241	substrate binding site [chemical binding]; other site
196162007242	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
196162007243	putative RNA binding site [nucleotide binding]; other site
196162007244	16S rRNA methyltransferase B; Provisional; Region: PRK14902
196162007245	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
196162007246	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
196162007247	nucleotide binding site [chemical binding]; other site
196162007248	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
196162007249	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
196162007250	substrate binding site [chemical binding]; other site
196162007251	hexamer interface [polypeptide binding]; other site
196162007252	metal binding site [ion binding]; metal-binding site
196162007253	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
196162007254	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
196162007255	catalytic motif [active]
196162007256	Zn binding site [ion binding]; other site
196162007257	RibD C-terminal domain; Region: RibD_C; pfam01872
196162007258	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
196162007259	Lumazine binding domain; Region: Lum_binding; pfam00677
196162007260	Lumazine binding domain; Region: Lum_binding; pfam00677
196162007261	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
196162007262	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
196162007263	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
196162007264	dimerization interface [polypeptide binding]; other site
196162007265	active site
196162007266	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
196162007267	homopentamer interface [polypeptide binding]; other site
196162007268	active site
196162007269	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
196162007270	homodimer interface [polypeptide binding]; other site
196162007271	putative metal binding site [ion binding]; other site
196162007272	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
196162007273	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
196162007274	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
196162007275	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
196162007276	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
196162007277	active site
196162007278	catalytic residues [active]
196162007279	AAA domain; Region: AAA_22; pfam13401
196162007280	hypothetical protein; Provisional; Region: PRK06547
196162007281	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
196162007282	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
196162007283	dimer interface [polypeptide binding]; other site
196162007284	active site
196162007285	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162007286	substrate binding site [chemical binding]; other site
196162007287	catalytic residue [active]
196162007288	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
196162007289	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
196162007290	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
196162007291	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
196162007292	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
196162007293	23S rRNA binding site [nucleotide binding]; other site
196162007294	L21 binding site [polypeptide binding]; other site
196162007295	L13 binding site [polypeptide binding]; other site
196162007296	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196162007297	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
196162007298	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
196162007299	alpha-glucosidase; Provisional; Region: PRK10426
196162007300	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
196162007301	putative active site [active]
196162007302	putative catalytic site [active]
196162007303	PAS domain; Region: PAS; smart00091
196162007304	putative active site [active]
196162007305	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162007306	dimer interface [polypeptide binding]; other site
196162007307	phosphorylation site [posttranslational modification]
196162007308	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162007309	ATP binding site [chemical binding]; other site
196162007310	Mg2+ binding site [ion binding]; other site
196162007311	G-X-G motif; other site
196162007312	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
196162007313	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
196162007314	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
196162007315	dimer interface [polypeptide binding]; other site
196162007316	motif 1; other site
196162007317	active site
196162007318	motif 2; other site
196162007319	motif 3; other site
196162007320	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
196162007321	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
196162007322	putative tRNA-binding site [nucleotide binding]; other site
196162007323	B3/4 domain; Region: B3_4; pfam03483
196162007324	tRNA synthetase B5 domain; Region: B5; smart00874
196162007325	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
196162007326	motif 1; other site
196162007327	dimer interface [polypeptide binding]; other site
196162007328	motif 3; other site
196162007329	motif 2; other site
196162007330	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
196162007331	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162007332	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
196162007333	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
196162007334	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
196162007335	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
196162007336	heterotetramer interface [polypeptide binding]; other site
196162007337	active site pocket [active]
196162007338	cleavage site
196162007339	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
196162007340	feedback inhibition sensing region; other site
196162007341	homohexameric interface [polypeptide binding]; other site
196162007342	nucleotide binding site [chemical binding]; other site
196162007343	N-acetyl-L-glutamate binding site [chemical binding]; other site
196162007344	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
196162007345	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162007346	inhibitor-cofactor binding pocket; inhibition site
196162007347	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162007348	catalytic residue [active]
196162007349	ornithine carbamoyltransferase; Provisional; Region: PRK00779
196162007350	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
196162007351	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
196162007352	arginine repressor; Provisional; Region: PRK03341
196162007353	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
196162007354	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
196162007355	argininosuccinate synthase; Validated; Region: PRK05370
196162007356	argininosuccinate synthase; Provisional; Region: PRK13820
196162007357	argininosuccinate lyase; Provisional; Region: PRK00855
196162007358	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
196162007359	active sites [active]
196162007360	tetramer interface [polypeptide binding]; other site
196162007361	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
196162007362	active site
196162007363	DNA binding site [nucleotide binding]
196162007364	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196162007365	dimer interface [polypeptide binding]; other site
196162007366	ssDNA binding site [nucleotide binding]; other site
196162007367	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196162007368	Uncharacterized conserved protein [Function unknown]; Region: COG4198
196162007369	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
196162007370	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162007371	active site
196162007372	motif I; other site
196162007373	motif II; other site
196162007374	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
196162007375	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
196162007376	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196162007377	RNA binding surface [nucleotide binding]; other site
196162007378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162007379	S-adenosylmethionine binding site [chemical binding]; other site
196162007380	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
196162007381	ATP-NAD kinase; Region: NAD_kinase; pfam01513
196162007382	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
196162007383	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162007384	Walker A/P-loop; other site
196162007385	ATP binding site [chemical binding]; other site
196162007386	Q-loop/lid; other site
196162007387	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
196162007388	ABC transporter signature motif; other site
196162007389	Walker B; other site
196162007390	D-loop; other site
196162007391	H-loop/switch region; other site
196162007392	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
196162007393	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
196162007394	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
196162007395	CTP synthetase; Validated; Region: pyrG; PRK05380
196162007396	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
196162007397	Catalytic site [active]
196162007398	active site
196162007399	UTP binding site [chemical binding]; other site
196162007400	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
196162007401	active site
196162007402	putative oxyanion hole; other site
196162007403	catalytic triad [active]
196162007404	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
196162007405	dimer interface [polypeptide binding]; other site
196162007406	active site
196162007407	ADP-ribose binding site [chemical binding]; other site
196162007408	nudix motif; other site
196162007409	metal binding site [ion binding]; metal-binding site
196162007410	SIR2-like domain; Region: SIR2_2; pfam13289
196162007411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
196162007412	phosphorylation site [posttranslational modification]
196162007413	intermolecular recognition site; other site
196162007414	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
196162007415	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
196162007416	hexamer interface [polypeptide binding]; other site
196162007417	ligand binding site [chemical binding]; other site
196162007418	putative active site [active]
196162007419	NAD(P) binding site [chemical binding]; other site
196162007420	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
196162007421	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162007422	active site
196162007423	DNA binding site [nucleotide binding]
196162007424	Int/Topo IB signature motif; other site
196162007425	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196162007426	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
196162007427	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162007428	ATP binding site [chemical binding]; other site
196162007429	putative Mg++ binding site [ion binding]; other site
196162007430	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162007431	nucleotide binding region [chemical binding]; other site
196162007432	ATP-binding site [chemical binding]; other site
196162007433	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
196162007434	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
196162007435	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162007436	Coenzyme A binding pocket [chemical binding]; other site
196162007437	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
196162007438	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162007439	P-loop; other site
196162007440	Magnesium ion binding site [ion binding]; other site
196162007441	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162007442	Magnesium ion binding site [ion binding]; other site
196162007443	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
196162007444	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
196162007445	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
196162007446	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196162007447	RNA binding surface [nucleotide binding]; other site
196162007448	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
196162007449	active site
196162007450	Domain of unknown function (DUF385); Region: DUF385; cl04387
196162007451	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
196162007452	homotrimer interaction site [polypeptide binding]; other site
196162007453	active site
196162007454	prephenate dehydrogenase; Validated; Region: PRK06545
196162007455	prephenate dehydrogenase; Validated; Region: PRK08507
196162007456	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
196162007457	cytidylate kinase; Provisional; Region: cmk; PRK00023
196162007458	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
196162007459	active site
196162007460	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
196162007461	CMP-binding site; other site
196162007462	The sites determining sugar specificity; other site
196162007463	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162007464	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196162007465	putative acyl-acceptor binding pocket; other site
196162007466	GTP-binding protein Der; Reviewed; Region: PRK03003
196162007467	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
196162007468	G1 box; other site
196162007469	GTP/Mg2+ binding site [chemical binding]; other site
196162007470	Switch I region; other site
196162007471	G2 box; other site
196162007472	Switch II region; other site
196162007473	G3 box; other site
196162007474	G4 box; other site
196162007475	G5 box; other site
196162007476	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
196162007477	G1 box; other site
196162007478	GTP/Mg2+ binding site [chemical binding]; other site
196162007479	Switch I region; other site
196162007480	G2 box; other site
196162007481	G3 box; other site
196162007482	Switch II region; other site
196162007483	G4 box; other site
196162007484	G5 box; other site
196162007485	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
196162007486	classical (c) SDRs; Region: SDR_c; cd05233
196162007487	NAD(P) binding site [chemical binding]; other site
196162007488	active site
196162007489	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162007490	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
196162007491	NAD(P) binding site [chemical binding]; other site
196162007492	active site
196162007493	cobyric acid synthase; Provisional; Region: PRK00784
196162007494	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162007495	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162007496	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
196162007497	catalytic triad [active]
196162007498	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
196162007499	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
196162007500	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
196162007501	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
196162007502	putative dimer interface [polypeptide binding]; other site
196162007503	active site pocket [active]
196162007504	putative cataytic base [active]
196162007505	AAA domain; Region: AAA_17; pfam13207
196162007506	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196162007507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196162007508	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196162007509	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162007510	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
196162007511	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
196162007512	active site
196162007513	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162007514	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162007515	active site
196162007516	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
196162007517	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
196162007518	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162007519	hydrophobic ligand binding site; other site
196162007520	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
196162007521	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
196162007522	FAD binding pocket [chemical binding]; other site
196162007523	FAD binding motif [chemical binding]; other site
196162007524	phosphate binding motif [ion binding]; other site
196162007525	beta-alpha-beta structure motif; other site
196162007526	NAD(p) ribose binding residues [chemical binding]; other site
196162007527	NAD binding pocket [chemical binding]; other site
196162007528	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
196162007529	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162007530	catalytic loop [active]
196162007531	iron binding site [ion binding]; other site
196162007532	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
196162007533	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162007534	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
196162007535	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
196162007536	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
196162007537	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
196162007538	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
196162007539	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
196162007540	iron-sulfur cluster [ion binding]; other site
196162007541	[2Fe-2S] cluster binding site [ion binding]; other site
196162007542	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
196162007543	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
196162007544	GIY-YIG motif/motif A; other site
196162007545	active site
196162007546	catalytic site [active]
196162007547	putative DNA binding site [nucleotide binding]; other site
196162007548	metal binding site [ion binding]; metal-binding site
196162007549	UvrB/uvrC motif; Region: UVR; pfam02151
196162007550	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
196162007551	Helix-hairpin-helix motif; Region: HHH; pfam00633
196162007552	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
196162007553	shikimate kinase; Reviewed; Region: aroK; PRK00131
196162007554	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
196162007555	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
196162007556	phosphate binding site [ion binding]; other site
196162007557	putative substrate binding pocket [chemical binding]; other site
196162007558	dimer interface [polypeptide binding]; other site
196162007559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
196162007560	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
196162007561	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
196162007562	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
196162007563	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
196162007564	Phosphoglycerate kinase; Region: PGK; pfam00162
196162007565	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
196162007566	substrate binding site [chemical binding]; other site
196162007567	hinge regions; other site
196162007568	ADP binding site [chemical binding]; other site
196162007569	catalytic site [active]
196162007570	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
196162007571	triosephosphate isomerase; Provisional; Region: PRK14567
196162007572	substrate binding site [chemical binding]; other site
196162007573	dimer interface [polypeptide binding]; other site
196162007574	catalytic triad [active]
196162007575	Preprotein translocase SecG subunit; Region: SecG; pfam03840
196162007576	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
196162007577	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
196162007578	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
196162007579	putative active site [active]
196162007580	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
196162007581	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
196162007582	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
196162007583	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
196162007584	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
196162007585	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
196162007586	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
196162007587	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
196162007588	putative active site [active]
196162007589	transaldolase; Provisional; Region: PRK03903
196162007590	catalytic residue [active]
196162007591	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
196162007592	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
196162007593	TPP-binding site [chemical binding]; other site
196162007594	dimer interface [polypeptide binding]; other site
196162007595	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
196162007596	PYR/PP interface [polypeptide binding]; other site
196162007597	dimer interface [polypeptide binding]; other site
196162007598	TPP binding site [chemical binding]; other site
196162007599	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196162007600	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
196162007601	UbiA prenyltransferase family; Region: UbiA; pfam01040
196162007602	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
196162007603	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
196162007604	ABC-2 type transporter; Region: ABC2_membrane; cl17235
196162007605	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162007606	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162007607	Walker A/P-loop; other site
196162007608	ATP binding site [chemical binding]; other site
196162007609	Q-loop/lid; other site
196162007610	ABC transporter signature motif; other site
196162007611	Walker B; other site
196162007612	D-loop; other site
196162007613	H-loop/switch region; other site
196162007614	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
196162007615	Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556
196162007616	active site
196162007617	catalytic site [active]
196162007618	metal binding site [ion binding]; metal-binding site
196162007619	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162007620	active site
196162007621	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162007622	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162007623	putative DNA binding site [nucleotide binding]; other site
196162007624	putative Zn2+ binding site [ion binding]; other site
196162007625	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
196162007626	FeS assembly protein SufB; Region: sufB; TIGR01980
196162007627	FeS assembly protein SufD; Region: sufD; TIGR01981
196162007628	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
196162007629	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
196162007630	[2Fe-2S] cluster binding site [ion binding]; other site
196162007631	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
196162007632	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
196162007633	Walker A/P-loop; other site
196162007634	ATP binding site [chemical binding]; other site
196162007635	Q-loop/lid; other site
196162007636	ABC transporter signature motif; other site
196162007637	Walker B; other site
196162007638	D-loop; other site
196162007639	H-loop/switch region; other site
196162007640	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
196162007641	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
196162007642	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162007643	catalytic residue [active]
196162007644	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
196162007645	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
196162007646	trimerization site [polypeptide binding]; other site
196162007647	active site
196162007648	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
196162007649	eRF1 domain 2; Region: eRF1_2; pfam03464
196162007650	Predicted transcriptional regulators [Transcription]; Region: COG1510
196162007651	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162007652	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162007653	Walker A/P-loop; other site
196162007654	ATP binding site [chemical binding]; other site
196162007655	Q-loop/lid; other site
196162007656	ABC transporter signature motif; other site
196162007657	Walker B; other site
196162007658	D-loop; other site
196162007659	H-loop/switch region; other site
196162007660	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
196162007661	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
196162007662	Phosphotransferase enzyme family; Region: APH; pfam01636
196162007663	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
196162007664	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
196162007665	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196162007666	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162007667	Walker A/P-loop; other site
196162007668	ATP binding site [chemical binding]; other site
196162007669	Q-loop/lid; other site
196162007670	ABC transporter signature motif; other site
196162007671	Walker B; other site
196162007672	D-loop; other site
196162007673	H-loop/switch region; other site
196162007674	ABC transporter; Region: ABC_tran_2; pfam12848
196162007675	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162007676	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
196162007677	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162007678	substrate binding site [chemical binding]; other site
196162007679	oxyanion hole (OAH) forming residues; other site
196162007680	trimer interface [polypeptide binding]; other site
196162007681	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162007682	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162007683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162007684	Walker A/P-loop; other site
196162007685	ATP binding site [chemical binding]; other site
196162007686	Q-loop/lid; other site
196162007687	ABC transporter signature motif; other site
196162007688	Walker B; other site
196162007689	D-loop; other site
196162007690	H-loop/switch region; other site
196162007691	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
196162007692	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
196162007693	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162007694	FeS/SAM binding site; other site
196162007695	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
196162007696	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
196162007697	Dodecin; Region: Dodecin; pfam07311
196162007698	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
196162007699	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
196162007700	NAD(P) binding site [chemical binding]; other site
196162007701	homotetramer interface [polypeptide binding]; other site
196162007702	homodimer interface [polypeptide binding]; other site
196162007703	active site
196162007704	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
196162007705	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
196162007706	NAD binding site [chemical binding]; other site
196162007707	homotetramer interface [polypeptide binding]; other site
196162007708	homodimer interface [polypeptide binding]; other site
196162007709	substrate binding site [chemical binding]; other site
196162007710	active site
196162007711	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162007712	catalytic core [active]
196162007713	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
196162007714	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
196162007715	phosphoserine phosphatase SerB; Region: serB; TIGR00338
196162007716	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196162007717	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
196162007718	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162007719	Walker A/P-loop; other site
196162007720	ATP binding site [chemical binding]; other site
196162007721	Q-loop/lid; other site
196162007722	ABC transporter signature motif; other site
196162007723	Walker B; other site
196162007724	D-loop; other site
196162007725	H-loop/switch region; other site
196162007726	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
196162007727	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
196162007728	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
196162007729	hypothetical protein; Provisional; Region: PRK10621
196162007730	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196162007731	FMN binding site [chemical binding]; other site
196162007732	Nitroreductase family; Region: Nitroreductase; pfam00881
196162007733	dimer interface [polypeptide binding]; other site
196162007734	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196162007735	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
196162007736	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
196162007737	active site
196162007738	catalytic site [active]
196162007739	Peptidase C26; Region: Peptidase_C26; pfam07722
196162007740	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
196162007741	catalytic triad [active]
196162007742	short chain dehydrogenase; Provisional; Region: PRK06057
196162007743	classical (c) SDRs; Region: SDR_c; cd05233
196162007744	NAD(P) binding site [chemical binding]; other site
196162007745	active site
196162007746	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162007747	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
196162007748	NAD(P) binding site [chemical binding]; other site
196162007749	catalytic residues [active]
196162007750	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
196162007751	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
196162007752	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162007753	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162007754	DNA-binding site [nucleotide binding]; DNA binding site
196162007755	FCD domain; Region: FCD; pfam07729
196162007756	amino acid permease (GABA permease); Region: 2A0304; TIGR00907
196162007757	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
196162007758	thiamine kinase; Region: ycfN_thiK; TIGR02721
196162007759	active site
196162007760	ATP binding site [chemical binding]; other site
196162007761	substrate binding site [chemical binding]; other site
196162007762	dimer interface [polypeptide binding]; other site
196162007763	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162007764	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162007765	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
196162007766	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
196162007767	Protein of unknown function (DUF419); Region: DUF419; pfam04237
196162007768	Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829
196162007769	active site
196162007770	putative catalytic site [active]
196162007771	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
196162007772	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162007773	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162007774	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196162007775	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
196162007776	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
196162007777	substrate binding site [chemical binding]; other site
196162007778	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
196162007779	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
196162007780	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
196162007781	homodimer interface [polypeptide binding]; other site
196162007782	active site
196162007783	SAM binding site [chemical binding]; other site
196162007784	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196162007785	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
196162007786	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
196162007787	active site
196162007788	catalytic residues [active]
196162007789	metal binding site [ion binding]; metal-binding site
196162007790	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162007791	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162007792	active site
196162007793	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162007794	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162007795	active site
196162007796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
196162007797	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
196162007798	galactokinase; Provisional; Region: PRK05101
196162007799	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
196162007800	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
196162007801	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
196162007802	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
196162007803	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196162007804	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
196162007805	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
196162007806	active site
196162007807	BCCT family transporter; Region: BCCT; pfam02028
196162007808	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196162007809	dimerization interface [polypeptide binding]; other site
196162007810	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
196162007811	FAD binding pocket [chemical binding]; other site
196162007812	conserved FAD binding motif [chemical binding]; other site
196162007813	phosphate binding motif [ion binding]; other site
196162007814	beta-alpha-beta structure motif; other site
196162007815	NAD binding pocket [chemical binding]; other site
196162007816	Transcriptional regulator [Transcription]; Region: LytR; COG1316
196162007817	Surface antigen [General function prediction only]; Region: COG3942
196162007818	CHAP domain; Region: CHAP; cl17642
196162007819	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605
196162007820	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
196162007821	acyl-activating enzyme (AAE) consensus motif; other site
196162007822	putative AMP binding site [chemical binding]; other site
196162007823	putative active site [active]
196162007824	putative CoA binding site [chemical binding]; other site
196162007825	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162007826	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
196162007827	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162007828	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
196162007829	acyl-activating enzyme (AAE) consensus motif; other site
196162007830	putative AMP binding site [chemical binding]; other site
196162007831	putative active site [active]
196162007832	putative CoA binding site [chemical binding]; other site
196162007833	hypothetical protein; Provisional; Region: PRK07906
196162007834	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
196162007835	putative metal binding site [ion binding]; other site
196162007836	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844
196162007837	active site
196162007838	catalytic triad [active]
196162007839	oxyanion hole [active]
196162007840	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162007841	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162007842	active site
196162007843	catalytic tetrad [active]
196162007844	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
196162007845	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
196162007846	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
196162007847	oligomer interface [polypeptide binding]; other site
196162007848	metal binding site [ion binding]; metal-binding site
196162007849	metal binding site [ion binding]; metal-binding site
196162007850	putative Cl binding site [ion binding]; other site
196162007851	basic sphincter; other site
196162007852	hydrophobic gate; other site
196162007853	periplasmic entrance; other site
196162007854	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162007855	catalytic core [active]
196162007856	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
196162007857	conserved hypothetical protein; Region: TIGR03843
196162007858	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162007859	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
196162007860	active site
196162007861	HIGH motif; other site
196162007862	nucleotide binding site [chemical binding]; other site
196162007863	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162007864	active site
196162007865	KMSKS motif; other site
196162007866	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
196162007867	putative dimer interface [polypeptide binding]; other site
196162007868	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162007869	PAC2 family; Region: PAC2; pfam09754
196162007870	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
196162007871	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
196162007872	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
196162007873	substrate binding pocket [chemical binding]; other site
196162007874	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
196162007875	B12 binding site [chemical binding]; other site
196162007876	cobalt ligand [ion binding]; other site
196162007877	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
196162007878	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
196162007879	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
196162007880	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162007881	motif II; other site
196162007882	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162007883	Histidine kinase; Region: HisKA_3; pfam07730
196162007884	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162007885	ATP binding site [chemical binding]; other site
196162007886	Mg2+ binding site [ion binding]; other site
196162007887	G-X-G motif; other site
196162007888	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162007889	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162007890	active site
196162007891	phosphorylation site [posttranslational modification]
196162007892	intermolecular recognition site; other site
196162007893	dimerization interface [polypeptide binding]; other site
196162007894	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162007895	DNA binding residues [nucleotide binding]
196162007896	dimerization interface [polypeptide binding]; other site
196162007897	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
196162007898	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
196162007899	Peptidase family M50; Region: Peptidase_M50; pfam02163
196162007900	active site
196162007901	putative substrate binding region [chemical binding]; other site
196162007902	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
196162007903	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
196162007904	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162007905	S-adenosylmethionine binding site [chemical binding]; other site
196162007906	proteasome ATPase; Region: pup_AAA; TIGR03689
196162007907	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162007908	Walker A motif; other site
196162007909	ATP binding site [chemical binding]; other site
196162007910	Walker B motif; other site
196162007911	arginine finger; other site
196162007912	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
196162007913	putative deacylase active site [active]
196162007914	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162007915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162007916	S-adenosylmethionine binding site [chemical binding]; other site
196162007917	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
196162007918	Pup-like protein; Region: Pup; cl05289
196162007919	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
196162007920	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
196162007921	active site
196162007922	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
196162007923	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
196162007924	active site
196162007925	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
196162007926	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
196162007927	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
196162007928	Predicted transcriptional regulator [Transcription]; Region: COG2378
196162007929	WYL domain; Region: WYL; pfam13280
196162007930	Predicted transcriptional regulator [Transcription]; Region: COG2378
196162007931	WYL domain; Region: WYL; pfam13280
196162007932	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
196162007933	mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416
196162007934	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
196162007935	diacylglycerol kinase; Reviewed; Region: PRK11914
196162007936	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
196162007937	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196162007938	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162007939	ATP binding site [chemical binding]; other site
196162007940	putative Mg++ binding site [ion binding]; other site
196162007941	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162007942	nucleotide binding region [chemical binding]; other site
196162007943	ATP-binding site [chemical binding]; other site
196162007944	rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234
196162007945	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
196162007946	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
196162007947	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162007948	NAD(P) binding site [chemical binding]; other site
196162007949	putative active site [active]
196162007950	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162007951	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
196162007952	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
196162007953	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
196162007954	active site
196162007955	metal binding site 1 [ion binding]; metal-binding site
196162007956	putative 5' ssDNA interaction site; other site
196162007957	metal binding site 3; metal-binding site
196162007958	metal binding site 2 [ion binding]; metal-binding site
196162007959	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
196162007960	putative DNA binding site [nucleotide binding]; other site
196162007961	putative metal binding site [ion binding]; other site
196162007962	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
196162007963	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162007964	putative DNA binding site [nucleotide binding]; other site
196162007965	putative Zn2+ binding site [ion binding]; other site
196162007966	AsnC family; Region: AsnC_trans_reg; pfam01037
196162007967	Radical SAM superfamily; Region: Radical_SAM; pfam04055
196162007968	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162007969	FeS/SAM binding site; other site
196162007970	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
196162007971	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
196162007972	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
196162007973	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
196162007974	B12 binding site [chemical binding]; other site
196162007975	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162007976	active site 2 [active]
196162007977	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
196162007978	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
196162007979	putative active site [active]
196162007980	catalytic triad [active]
196162007981	putative dimer interface [polypeptide binding]; other site
196162007982	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
196162007983	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
196162007984	Ligand binding site; other site
196162007985	Putative Catalytic site; other site
196162007986	DXD motif; other site
196162007987	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
196162007988	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
196162007989	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
196162007990	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
196162007991	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
196162007992	putative active site [active]
196162007993	catalytic site [active]
196162007994	putative metal binding site [ion binding]; other site
196162007995	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196162007996	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162007997	non-specific DNA binding site [nucleotide binding]; other site
196162007998	salt bridge; other site
196162007999	sequence-specific DNA binding site [nucleotide binding]; other site
196162008000	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
196162008001	This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while  RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288
196162008002	putative active site [active]
196162008003	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
196162008004	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162008005	catalytic Zn binding site [ion binding]; other site
196162008006	NAD(P) binding site [chemical binding]; other site
196162008007	structural Zn binding site [ion binding]; other site
196162008008	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
196162008009	putative active site [active]
196162008010	putative metal binding site [ion binding]; other site
196162008011	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
196162008012	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
196162008013	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
196162008014	DinB superfamily; Region: DinB_2; pfam12867
196162008015	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
196162008016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196162008017	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162008018	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
196162008019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162008020	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
196162008021	Walker A/P-loop; other site
196162008022	ATP binding site [chemical binding]; other site
196162008023	Q-loop/lid; other site
196162008024	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
196162008025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162008026	Walker A/P-loop; other site
196162008027	ATP binding site [chemical binding]; other site
196162008028	Q-loop/lid; other site
196162008029	ABC transporter signature motif; other site
196162008030	Walker B; other site
196162008031	D-loop; other site
196162008032	H-loop/switch region; other site
196162008033	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
196162008034	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
196162008035	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
196162008036	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162008037	Zn binding site [ion binding]; other site
196162008038	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
196162008039	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162008040	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
196162008041	YhhN-like protein; Region: YhhN; pfam07947
196162008042	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162008043	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162008044	active site
196162008045	catalytic tetrad [active]
196162008046	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
196162008047	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
196162008048	dimer interface [polypeptide binding]; other site
196162008049	active site
196162008050	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162008051	substrate binding site [chemical binding]; other site
196162008052	catalytic residue [active]
196162008053	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
196162008054	active site
196162008055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008056	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
196162008057	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
196162008058	Uncharacterized conserved protein [Function unknown]; Region: COG3391
196162008059	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
196162008060	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162008061	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162008062	catalytic residue [active]
196162008063	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
196162008064	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
196162008065	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
196162008066	Zn binding site [ion binding]; other site
196162008067	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
196162008068	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
196162008069	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
196162008070	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
196162008071	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
196162008072	active site
196162008073	metal binding site [ion binding]; metal-binding site
196162008074	DNA binding site [nucleotide binding]
196162008075	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
196162008076	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
196162008077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162008078	Walker A/P-loop; other site
196162008079	ATP binding site [chemical binding]; other site
196162008080	Q-loop/lid; other site
196162008081	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
196162008082	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
196162008083	ABC transporter signature motif; other site
196162008084	Walker B; other site
196162008085	D-loop; other site
196162008086	H-loop/switch region; other site
196162008087	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
196162008088	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
196162008089	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374
196162008090	putative active site; other site
196162008091	putative metal binding residues [ion binding]; other site
196162008092	signature motif; other site
196162008093	putative triphosphate binding site [ion binding]; other site
196162008094	CHAD domain; Region: CHAD; pfam05235
196162008095	Beta-lactamase; Region: Beta-lactamase; pfam00144
196162008096	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
196162008097	glycine dehydrogenase; Provisional; Region: PRK05367
196162008098	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162008099	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162008100	catalytic residue [active]
196162008101	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
196162008102	tetramer interface [polypeptide binding]; other site
196162008103	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162008104	catalytic residue [active]
196162008105	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
196162008106	DNA binding residues [nucleotide binding]
196162008107	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196162008108	putative dimer interface [polypeptide binding]; other site
196162008109	Bifunctional nuclease; Region: DNase-RNase; pfam02577
196162008110	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
196162008111	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196162008112	DNA binding residues [nucleotide binding]
196162008113	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
196162008114	Double zinc ribbon; Region: DZR; pfam12773
196162008115	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
196162008116	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
196162008117	phosphopeptide binding site; other site
196162008118	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
196162008119	lipoyl attachment site [posttranslational modification]; other site
196162008120	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
196162008121	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
196162008122	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
196162008123	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
196162008124	Domain of unknown function DUF21; Region: DUF21; pfam01595
196162008125	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196162008126	FOG: CBS domain [General function prediction only]; Region: COG0517
196162008127	Domain of unknown function DUF21; Region: DUF21; pfam01595
196162008128	FOG: CBS domain [General function prediction only]; Region: COG0517
196162008129	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
196162008130	Transporter associated domain; Region: CorC_HlyC; cl08393
196162008131	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
196162008132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
196162008133	Nitroreductase family; Region: Nitroreductase; pfam00881
196162008134	Nitronate monooxygenase; Region: NMO; pfam03060
196162008135	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196162008136	FMN binding site [chemical binding]; other site
196162008137	substrate binding site [chemical binding]; other site
196162008138	putative catalytic residue [active]
196162008139	acyl-CoA synthetase; Validated; Region: PRK07798
196162008140	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162008141	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
196162008142	acyl-activating enzyme (AAE) consensus motif; other site
196162008143	acyl-activating enzyme (AAE) consensus motif; other site
196162008144	putative AMP binding site [chemical binding]; other site
196162008145	putative active site [active]
196162008146	putative CoA binding site [chemical binding]; other site
196162008147	enoyl-CoA hydratase; Provisional; Region: PRK07799
196162008148	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162008149	substrate binding site [chemical binding]; other site
196162008150	oxyanion hole (OAH) forming residues; other site
196162008151	trimer interface [polypeptide binding]; other site
196162008152	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162008153	active site
196162008154	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162008155	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162008156	DNA binding site [nucleotide binding]
196162008157	domain linker motif; other site
196162008158	acyl-CoA synthetase; Validated; Region: PRK06188
196162008159	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
196162008160	putative active site [active]
196162008161	putative CoA binding site [chemical binding]; other site
196162008162	putative AMP binding site [chemical binding]; other site
196162008163	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162008164	putative catalytic site [active]
196162008165	putative metal binding site [ion binding]; other site
196162008166	putative phosphate binding site [ion binding]; other site
196162008167	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
196162008168	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162008169	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
196162008170	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162008171	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
196162008172	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
196162008173	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162008174	lipid-transfer protein; Provisional; Region: PRK07937
196162008175	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162008176	active site
196162008177	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
196162008178	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162008179	active site
196162008180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162008181	non-specific DNA binding site [nucleotide binding]; other site
196162008182	salt bridge; other site
196162008183	sequence-specific DNA binding site [nucleotide binding]; other site
196162008184	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
196162008185	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
196162008186	oligomer interface [polypeptide binding]; other site
196162008187	active site residues [active]
196162008188	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
196162008189	Clp protease; Region: CLP_protease; pfam00574
196162008190	oligomer interface [polypeptide binding]; other site
196162008191	active site residues [active]
196162008192	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
196162008193	active site
196162008194	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162008195	Cytochrome P450; Region: p450; cl12078
196162008196	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
196162008197	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162008198	dimer interface [polypeptide binding]; other site
196162008199	active site
196162008200	short chain dehydrogenase; Provisional; Region: PRK07791
196162008201	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008202	NAD(P) binding site [chemical binding]; other site
196162008203	active site
196162008204	short chain dehydrogenase; Provisional; Region: PRK07856
196162008205	classical (c) SDRs; Region: SDR_c; cd05233
196162008206	NAD(P) binding site [chemical binding]; other site
196162008207	active site
196162008208	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162008209	enoyl-CoA hydratase; Provisional; Region: PRK06495
196162008210	substrate binding site [chemical binding]; other site
196162008211	oxyanion hole (OAH) forming residues; other site
196162008212	trimer interface [polypeptide binding]; other site
196162008213	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
196162008214	Coenzyme A transferase; Region: CoA_trans; cl17247
196162008215	Nitronate monooxygenase; Region: NMO; pfam03060
196162008216	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196162008217	FMN binding site [chemical binding]; other site
196162008218	substrate binding site [chemical binding]; other site
196162008219	putative catalytic residue [active]
196162008220	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
196162008221	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
196162008222	Integrase core domain; Region: rve; pfam00665
196162008223	Integrase core domain; Region: rve_3; pfam13683
196162008224	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
196162008225	Integrase core domain; Region: rve; pfam00665
196162008226	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
196162008227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162008228	Walker A motif; other site
196162008229	ATP binding site [chemical binding]; other site
196162008230	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196162008231	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162008232	MarR family; Region: MarR_2; pfam12802
196162008233	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
196162008234	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162008235	dimer interface [polypeptide binding]; other site
196162008236	active site
196162008237	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162008238	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162008239	short chain dehydrogenase; Provisional; Region: PRK07831
196162008240	classical (c) SDRs; Region: SDR_c; cd05233
196162008241	NAD(P) binding site [chemical binding]; other site
196162008242	active site
196162008243	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008244	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
196162008245	active site
196162008246	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
196162008247	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162008248	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
196162008249	acyl-activating enzyme (AAE) consensus motif; other site
196162008250	acyl-activating enzyme (AAE) consensus motif; other site
196162008251	putative AMP binding site [chemical binding]; other site
196162008252	putative active site [active]
196162008253	putative CoA binding site [chemical binding]; other site
196162008254	CoA binding site [chemical binding]; other site
196162008255	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008256	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008257	active site
196162008258	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008259	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008260	active site
196162008261	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008262	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
196162008263	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008264	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008265	active site
196162008266	Cupin domain; Region: Cupin_2; cl17218
196162008267	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
196162008268	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
196162008269	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
196162008270	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
196162008271	active site
196162008272	Fe binding site [ion binding]; other site
196162008273	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162008274	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162008275	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008276	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
196162008277	Flavin binding site [chemical binding]; other site
196162008278	acetaldehyde dehydrogenase; Validated; Region: PRK08300
196162008279	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
196162008280	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
196162008281	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196162008282	enoyl-CoA hydratase; Region: PLN02864
196162008283	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162008284	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
196162008285	dimer interaction site [polypeptide binding]; other site
196162008286	substrate-binding tunnel; other site
196162008287	active site
196162008288	catalytic site [active]
196162008289	substrate binding site [chemical binding]; other site
196162008290	Protein of unknown function, DUF480; Region: DUF480; pfam04337
196162008291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008292	S-adenosylmethionine binding site [chemical binding]; other site
196162008293	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
196162008294	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
196162008295	lipid-transfer protein; Provisional; Region: PRK07855
196162008296	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162008297	active site
196162008298	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
196162008299	putative active site [active]
196162008300	putative catalytic site [active]
196162008301	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
196162008302	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162008303	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008304	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008305	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008306	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008307	active site
196162008308	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162008309	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
196162008310	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
196162008311	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
196162008312	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162008313	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
196162008314	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
196162008315	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008316	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008317	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162008318	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162008319	active site
196162008320	Methyltransferase domain; Region: Methyltransf_24; pfam13578
196162008321	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
196162008322	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
196162008323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008324	S-adenosylmethionine binding site [chemical binding]; other site
196162008325	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162008326	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196162008327	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162008328	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162008329	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
196162008330	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
196162008331	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
196162008332	G1 box; other site
196162008333	putative GEF interaction site [polypeptide binding]; other site
196162008334	GTP/Mg2+ binding site [chemical binding]; other site
196162008335	Switch I region; other site
196162008336	G2 box; other site
196162008337	G3 box; other site
196162008338	Switch II region; other site
196162008339	G4 box; other site
196162008340	G5 box; other site
196162008341	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
196162008342	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162008343	dimerization interface [polypeptide binding]; other site
196162008344	putative DNA binding site [nucleotide binding]; other site
196162008345	Transcriptional regulators [Transcription]; Region: MarR; COG1846
196162008346	putative Zn2+ binding site [ion binding]; other site
196162008347	Low molecular weight phosphatase family; Region: LMWPc; cd00115
196162008348	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196162008349	active site
196162008350	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162008351	active site
196162008352	metal binding site [ion binding]; metal-binding site
196162008353	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162008354	hypothetical protein; Provisional; Region: PRK02237
196162008355	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162008356	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162008357	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162008358	Walker A/P-loop; other site
196162008359	ATP binding site [chemical binding]; other site
196162008360	Q-loop/lid; other site
196162008361	ABC transporter signature motif; other site
196162008362	Walker B; other site
196162008363	D-loop; other site
196162008364	H-loop/switch region; other site
196162008365	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162008366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162008367	Walker A/P-loop; other site
196162008368	ATP binding site [chemical binding]; other site
196162008369	Q-loop/lid; other site
196162008370	ABC transporter signature motif; other site
196162008371	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
196162008372	anti sigma factor interaction site; other site
196162008373	regulatory phosphorylation site [posttranslational modification]; other site
196162008374	Domain of unknown function (DUF222); Region: DUF222; pfam02720
196162008375	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162008376	active site
196162008377	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162008378	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008379	S-adenosylmethionine binding site [chemical binding]; other site
196162008380	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
196162008381	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
196162008382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008383	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162008384	NAD(P) binding site [chemical binding]; other site
196162008385	active site
196162008386	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
196162008387	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008388	NAD(P) binding site [chemical binding]; other site
196162008389	active site
196162008390	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
196162008391	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
196162008392	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
196162008393	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162008394	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162008395	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
196162008396	mce related protein; Region: MCE; pfam02470
196162008397	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162008398	mce related protein; Region: MCE; pfam02470
196162008399	mce related protein; Region: MCE; pfam02470
196162008400	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162008401	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162008402	mce related protein; Region: MCE; pfam02470
196162008403	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162008404	mce related protein; Region: MCE; pfam02470
196162008405	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
196162008406	mce related protein; Region: MCE; pfam02470
196162008407	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
196162008408	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
196162008409	Permease; Region: Permease; pfam02405
196162008410	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
196162008411	Permease; Region: Permease; pfam02405
196162008412	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196162008413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162008414	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162008415	active site
196162008416	phosphorylation site [posttranslational modification]
196162008417	intermolecular recognition site; other site
196162008418	dimerization interface [polypeptide binding]; other site
196162008419	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162008420	DNA binding site [nucleotide binding]
196162008421	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
196162008422	GAF domain; Region: GAF; pfam01590
196162008423	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
196162008424	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
196162008425	active site
196162008426	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162008427	active site
196162008428	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162008429	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
196162008430	anti sigma factor interaction site; other site
196162008431	regulatory phosphorylation site [posttranslational modification]; other site
196162008432	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
196162008433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
196162008434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162008435	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162008436	putative substrate translocation pore; other site
196162008437	active site
196162008438	metal binding site [ion binding]; metal-binding site
196162008439	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
196162008440	excinuclease ABC subunit B; Provisional; Region: PRK05298
196162008441	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162008442	putative Mg++ binding site [ion binding]; other site
196162008443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162008444	nucleotide binding region [chemical binding]; other site
196162008445	ATP-binding site [chemical binding]; other site
196162008446	Ultra-violet resistance protein B; Region: UvrB; pfam12344
196162008447	UvrB/uvrC motif; Region: UVR; pfam02151
196162008448	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
196162008449	PLD-like domain; Region: PLDc_2; pfam13091
196162008450	putative active site [active]
196162008451	catalytic site [active]
196162008452	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
196162008453	PLD-like domain; Region: PLDc_2; pfam13091
196162008454	putative active site [active]
196162008455	catalytic site [active]
196162008456	Uncharacterized conserved protein [Function unknown]; Region: COG2128
196162008457	short chain dehydrogenase; Provisional; Region: PRK07832
196162008458	classical (c) SDRs; Region: SDR_c; cd05233
196162008459	NAD(P) binding site [chemical binding]; other site
196162008460	active site
196162008461	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
196162008462	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
196162008463	helix-hairpin-helix signature motif; other site
196162008464	active site
196162008465	5'-3' exonuclease; Region: 53EXOc; smart00475
196162008466	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
196162008467	active site
196162008468	putative 5' ssDNA interaction site; other site
196162008469	metal binding site 3; metal-binding site
196162008470	metal binding site 1 [ion binding]; metal-binding site
196162008471	metal binding site 2 [ion binding]; metal-binding site
196162008472	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
196162008473	putative DNA binding site [nucleotide binding]; other site
196162008474	putative metal binding site [ion binding]; other site
196162008475	Uncharacterized conserved protein [Function unknown]; Region: COG4850
196162008476	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
196162008477	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
196162008478	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
196162008479	active site
196162008480	DNA binding site [nucleotide binding]
196162008481	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
196162008482	DNA binding site [nucleotide binding]
196162008483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162008484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162008485	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
196162008486	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162008487	dimer interface [polypeptide binding]; other site
196162008488	active site
196162008489	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
196162008490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008491	NAD(P) binding site [chemical binding]; other site
196162008492	active site
196162008493	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162008494	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162008495	active site 2 [active]
196162008496	active site 1 [active]
196162008497	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
196162008498	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
196162008499	active site
196162008500	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
196162008501	catalytic triad [active]
196162008502	dimer interface [polypeptide binding]; other site
196162008503	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
196162008504	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
196162008505	active site
196162008506	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
196162008507	catalytic triad [active]
196162008508	dimer interface [polypeptide binding]; other site
196162008509	PAC2 family; Region: PAC2; pfam09754
196162008510	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162008511	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
196162008512	dimer interface [polypeptide binding]; other site
196162008513	active site
196162008514	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
196162008515	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162008516	substrate binding site [chemical binding]; other site
196162008517	oxyanion hole (OAH) forming residues; other site
196162008518	trimer interface [polypeptide binding]; other site
196162008519	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162008520	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162008521	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162008522	PAS domain S-box; Region: sensory_box; TIGR00229
196162008523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162008524	putative active site [active]
196162008525	heme pocket [chemical binding]; other site
196162008526	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162008527	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162008528	dimer interface [polypeptide binding]; other site
196162008529	phosphorylation site [posttranslational modification]
196162008530	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162008531	ATP binding site [chemical binding]; other site
196162008532	Mg2+ binding site [ion binding]; other site
196162008533	G-X-G motif; other site
196162008534	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
196162008535	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
196162008536	nucleotide binding site [chemical binding]; other site
196162008537	amino acid transporter; Region: 2A0306; TIGR00909
196162008538	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
196162008539	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
196162008540	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
196162008541	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
196162008542	TPP-binding site; other site
196162008543	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
196162008544	PYR/PP interface [polypeptide binding]; other site
196162008545	dimer interface [polypeptide binding]; other site
196162008546	TPP binding site [chemical binding]; other site
196162008547	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196162008548	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
196162008549	Strictosidine synthase; Region: Str_synth; pfam03088
196162008550	NUDIX domain; Region: NUDIX; pfam00293
196162008551	nudix motif; other site
196162008552	nudix motif; other site
196162008553	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
196162008554	active site
196162008555	Glyco_18 domain; Region: Glyco_18; smart00636
196162008556	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
196162008557	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
196162008558	AAA ATPase domain; Region: AAA_16; pfam13191
196162008559	MMPL family; Region: MMPL; pfam03176
196162008560	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162008561	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
196162008562	Walker A/P-loop; other site
196162008563	ATP binding site [chemical binding]; other site
196162008564	Q-loop/lid; other site
196162008565	ABC transporter signature motif; other site
196162008566	Walker B; other site
196162008567	D-loop; other site
196162008568	H-loop/switch region; other site
196162008569	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196162008570	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162008571	Walker A/P-loop; other site
196162008572	ATP binding site [chemical binding]; other site
196162008573	Q-loop/lid; other site
196162008574	ABC transporter signature motif; other site
196162008575	Walker B; other site
196162008576	D-loop; other site
196162008577	H-loop/switch region; other site
196162008578	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
196162008579	DNA-binding site [nucleotide binding]; DNA binding site
196162008580	RNA-binding motif; other site
196162008581	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
196162008582	Domain of unknown function DUF77; Region: DUF77; pfam01910
196162008583	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162008584	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162008585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162008586	DNA binding residues [nucleotide binding]
196162008587	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196162008588	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196162008589	aconitate hydratase; Validated; Region: PRK09277
196162008590	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
196162008591	substrate binding site [chemical binding]; other site
196162008592	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
196162008593	ligand binding site [chemical binding]; other site
196162008594	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
196162008595	substrate binding site [chemical binding]; other site
196162008596	Predicted membrane protein [Function unknown]; Region: COG2259
196162008597	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
196162008598	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
196162008599	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
196162008600	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
196162008601	active site
196162008602	SAM binding site [chemical binding]; other site
196162008603	homodimer interface [polypeptide binding]; other site
196162008604	cobyric acid synthase; Provisional; Region: PRK00784
196162008605	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
196162008606	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
196162008607	catalytic triad [active]
196162008608	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
196162008609	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
196162008610	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
196162008611	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
196162008612	dimer interface [polypeptide binding]; other site
196162008613	[2Fe-2S] cluster binding site [ion binding]; other site
196162008614	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
196162008615	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
196162008616	putative dimer interface [polypeptide binding]; other site
196162008617	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
196162008618	active site pocket [active]
196162008619	putative cataytic base [active]
196162008620	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
196162008621	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162008622	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
196162008623	catalytic triad [active]
196162008624	hypothetical protein; Provisional; Region: PRK07908
196162008625	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162008626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162008627	homodimer interface [polypeptide binding]; other site
196162008628	catalytic residue [active]
196162008629	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
196162008630	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
196162008631	homodimer interface [polypeptide binding]; other site
196162008632	Walker A motif; other site
196162008633	ATP binding site [chemical binding]; other site
196162008634	hydroxycobalamin binding site [chemical binding]; other site
196162008635	Walker B motif; other site
196162008636	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
196162008637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162008638	Walker A motif; other site
196162008639	ATP binding site [chemical binding]; other site
196162008640	Walker B motif; other site
196162008641	arginine finger; other site
196162008642	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
196162008643	metal ion-dependent adhesion site (MIDAS); other site
196162008644	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
196162008645	active site
196162008646	putative homodimer interface [polypeptide binding]; other site
196162008647	SAM binding site [chemical binding]; other site
196162008648	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
196162008649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008650	S-adenosylmethionine binding site [chemical binding]; other site
196162008651	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
196162008652	active site
196162008653	homodimer interface [polypeptide binding]; other site
196162008654	SAM binding site [chemical binding]; other site
196162008655	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
196162008656	active site
196162008657	SAM binding site [chemical binding]; other site
196162008658	homodimer interface [polypeptide binding]; other site
196162008659	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
196162008660	homodimer interface [polypeptide binding]; other site
196162008661	active site
196162008662	SAM binding site [chemical binding]; other site
196162008663	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
196162008664	Precorrin-8X methylmutase; Region: CbiC; pfam02570
196162008665	precorrin-3B synthase; Region: CobG; TIGR02435
196162008666	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196162008667	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
196162008668	GAF domain; Region: GAF; pfam01590
196162008669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162008670	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162008671	dimer interface [polypeptide binding]; other site
196162008672	phosphorylation site [posttranslational modification]
196162008673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162008674	ATP binding site [chemical binding]; other site
196162008675	Mg2+ binding site [ion binding]; other site
196162008676	G-X-G motif; other site
196162008677	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
196162008678	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
196162008679	putative hydrophobic ligand binding site [chemical binding]; other site
196162008680	Helix-turn-helix domain; Region: HTH_17; cl17695
196162008681	TRAM domain; Region: TRAM; cl01282
196162008682	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
196162008683	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008684	S-adenosylmethionine binding site [chemical binding]; other site
196162008685	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
196162008686	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
196162008687	TrkA-N domain; Region: TrkA_N; pfam02254
196162008688	TrkA-C domain; Region: TrkA_C; pfam02080
196162008689	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
196162008690	TrkA-N domain; Region: TrkA_N; pfam02254
196162008691	TrkA-C domain; Region: TrkA_C; pfam02080
196162008692	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
196162008693	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
196162008694	ssDNA binding site; other site
196162008695	generic binding surface II; other site
196162008696	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
196162008697	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
196162008698	trimer interface [polypeptide binding]; other site
196162008699	active site
196162008700	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
196162008701	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
196162008702	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
196162008703	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
196162008704	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196162008705	active site
196162008706	dimerization interface [polypeptide binding]; other site
196162008707	ferrochelatase; Reviewed; Region: hemH; PRK00035
196162008708	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
196162008709	C-terminal domain interface [polypeptide binding]; other site
196162008710	active site
196162008711	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
196162008712	active site
196162008713	N-terminal domain interface [polypeptide binding]; other site
196162008714	Predicted membrane protein [Function unknown]; Region: COG2860
196162008715	UPF0126 domain; Region: UPF0126; pfam03458
196162008716	UPF0126 domain; Region: UPF0126; pfam03458
196162008717	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
196162008718	short chain dehydrogenase; Provisional; Region: PRK07201
196162008719	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
196162008720	putative NAD(P) binding site [chemical binding]; other site
196162008721	active site
196162008722	putative substrate binding site [chemical binding]; other site
196162008723	classical (c) SDRs; Region: SDR_c; cd05233
196162008724	NAD(P) binding site [chemical binding]; other site
196162008725	active site
196162008726	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
196162008727	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
196162008728	active site residue [active]
196162008729	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
196162008730	active site residue [active]
196162008731	thymidine kinase; Provisional; Region: PRK04296
196162008732	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
196162008733	putative homodimer interface [polypeptide binding]; other site
196162008734	putative homotetramer interface [polypeptide binding]; other site
196162008735	putative allosteric switch controlling residues; other site
196162008736	putative metal binding site [ion binding]; other site
196162008737	putative homodimer-homodimer interface [polypeptide binding]; other site
196162008738	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
196162008739	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
196162008740	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162008741	Soluble P-type ATPase [General function prediction only]; Region: COG4087
196162008742	Uncharacterized conserved protein [Function unknown]; Region: COG3350
196162008743	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
196162008744	Multicopper oxidase; Region: Cu-oxidase; pfam00394
196162008745	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
196162008746	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
196162008747	Predicted membrane protein [Function unknown]; Region: COG3462
196162008748	Short C-terminal domain; Region: SHOCT; pfam09851
196162008749	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162008750	dimerization interface [polypeptide binding]; other site
196162008751	putative DNA binding site [nucleotide binding]; other site
196162008752	putative Zn2+ binding site [ion binding]; other site
196162008753	Domain of unknown function (DUF202); Region: DUF202; pfam02656
196162008754	Domain of unknown function (DUF202); Region: DUF202; cl09954
196162008755	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
196162008756	active site residue [active]
196162008757	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
196162008758	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
196162008759	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
196162008760	CPxP  motif; other site
196162008761	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
196162008762	4Fe-4S binding domain; Region: Fer4; pfam00037
196162008763	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
196162008764	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
196162008765	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
196162008766	molybdopterin cofactor binding site; other site
196162008767	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
196162008768	putative molybdopterin cofactor binding site; other site
196162008769	Domain of unknown function DUF59; Region: DUF59; cl00941
196162008770	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
196162008771	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
196162008772	Walker A motif; other site
196162008773	high affinity sulphate transporter 1; Region: sulP; TIGR00815
196162008774	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
196162008775	Sulfate transporter family; Region: Sulfate_transp; pfam00916
196162008776	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
196162008777	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
196162008778	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
196162008779	active site residue [active]
196162008780	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162008781	dimerization interface [polypeptide binding]; other site
196162008782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162008783	dimer interface [polypeptide binding]; other site
196162008784	phosphorylation site [posttranslational modification]
196162008785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162008786	ATP binding site [chemical binding]; other site
196162008787	G-X-G motif; other site
196162008788	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162008789	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162008790	active site
196162008791	phosphorylation site [posttranslational modification]
196162008792	intermolecular recognition site; other site
196162008793	dimerization interface [polypeptide binding]; other site
196162008794	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162008795	DNA binding site [nucleotide binding]
196162008796	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
196162008797	active site
196162008798	oxyanion hole [active]
196162008799	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162008800	Histidine kinase; Region: HisKA_3; pfam07730
196162008801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162008802	ATP binding site [chemical binding]; other site
196162008803	Mg2+ binding site [ion binding]; other site
196162008804	G-X-G motif; other site
196162008805	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162008806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162008807	active site
196162008808	phosphorylation site [posttranslational modification]
196162008809	intermolecular recognition site; other site
196162008810	dimerization interface [polypeptide binding]; other site
196162008811	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162008812	DNA binding residues [nucleotide binding]
196162008813	dimerization interface [polypeptide binding]; other site
196162008814	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
196162008815	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
196162008816	interchain domain interface [polypeptide binding]; other site
196162008817	intrachain domain interface; other site
196162008818	heme bH binding site [chemical binding]; other site
196162008819	heme bL binding site [chemical binding]; other site
196162008820	Qo binding site; other site
196162008821	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
196162008822	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
196162008823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196162008824	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162008825	Coenzyme A binding pocket [chemical binding]; other site
196162008826	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
196162008827	CoA binding domain; Region: CoA_binding; smart00881
196162008828	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
196162008829	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
196162008830	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
196162008831	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
196162008832	CAP-like domain; other site
196162008833	active site
196162008834	primary dimer interface [polypeptide binding]; other site
196162008835	Protein of unknown function (DUF1396); Region: DUF1396; pfam07161
196162008836	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162008837	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162008838	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
196162008839	active site clefts [active]
196162008840	zinc binding site [ion binding]; other site
196162008841	dimer interface [polypeptide binding]; other site
196162008842	propionate/acetate kinase; Provisional; Region: PRK12379
196162008843	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
196162008844	phosphate acetyltransferase; Reviewed; Region: PRK05632
196162008845	DRTGG domain; Region: DRTGG; pfam07085
196162008846	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
196162008847	CrcB-like protein; Region: CRCB; cl09114
196162008848	PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993
196162008849	CrcB-like protein; Region: CRCB; pfam02537
196162008850	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
196162008851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162008852	ATP binding site [chemical binding]; other site
196162008853	Mg2+ binding site [ion binding]; other site
196162008854	G-X-G motif; other site
196162008855	DNA gyrase B; Region: DNA_gyraseB; pfam00204
196162008856	ATP binding site [chemical binding]; other site
196162008857	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
196162008858	active site
196162008859	metal binding site [ion binding]; metal-binding site
196162008860	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
196162008861	Protein of unknown function (DUF456); Region: DUF456; pfam04306
196162008862	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
196162008863	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
196162008864	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
196162008865	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162008866	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162008867	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162008868	DNA binding residues [nucleotide binding]
196162008869	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
196162008870	minor groove reading motif; other site
196162008871	helix-hairpin-helix signature motif; other site
196162008872	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162008873	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162008874	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
196162008875	homodimer interface [polypeptide binding]; other site
196162008876	active site
196162008877	TDP-binding site; other site
196162008878	acceptor substrate-binding pocket; other site
196162008879	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
196162008880	Ligand Binding Site [chemical binding]; other site
196162008881	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
196162008882	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
196162008883	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
196162008884	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
196162008885	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196162008886	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
196162008887	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162008888	active site
196162008889	catalytic residues [active]
196162008890	DNA binding site [nucleotide binding]
196162008891	Int/Topo IB signature motif; other site
196162008892	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162008893	DNA binding site [nucleotide binding]
196162008894	Int/Topo IB signature motif; other site
196162008895	active site
196162008896	catalytic residues [active]
196162008897	DNA polymerase IV; Provisional; Region: PRK03348
196162008898	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
196162008899	active site
196162008900	DNA binding site [nucleotide binding]
196162008901	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
196162008902	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
196162008903	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
196162008904	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
196162008905	putative active site [active]
196162008906	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
196162008907	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162008908	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
196162008909	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
196162008910	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162008911	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162008912	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162008913	DNA binding residues [nucleotide binding]
196162008914	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
196162008915	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
196162008916	CoA-binding site [chemical binding]; other site
196162008917	ATP-binding [chemical binding]; other site
196162008918	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
196162008919	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162008920	dimerization interface [polypeptide binding]; other site
196162008921	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
196162008922	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
196162008923	dimer interface [polypeptide binding]; other site
196162008924	putative CheW interface [polypeptide binding]; other site
196162008925	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008926	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
196162008927	NAD(P) binding site [chemical binding]; other site
196162008928	active site
196162008929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162008930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162008931	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276
196162008932	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162008933	acyl-activating enzyme (AAE) consensus motif; other site
196162008934	AMP binding site [chemical binding]; other site
196162008935	active site
196162008936	CoA binding site [chemical binding]; other site
196162008937	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
196162008938	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
196162008939	conserved cys residue [active]
196162008940	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196162008941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196162008942	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
196162008943	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
196162008944	RNA binding site [nucleotide binding]; other site
196162008945	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
196162008946	RNA binding site [nucleotide binding]; other site
196162008947	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
196162008948	RNA binding site [nucleotide binding]; other site
196162008949	S1 RNA binding domain; Region: S1; pfam00575
196162008950	RNA binding site [nucleotide binding]; other site
196162008951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008952	S-adenosylmethionine binding site [chemical binding]; other site
196162008953	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
196162008954	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162008955	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008956	S-adenosylmethionine binding site [chemical binding]; other site
196162008957	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196162008958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162008959	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
196162008960	NAD(P) binding site [chemical binding]; other site
196162008961	active site
196162008962	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
196162008963	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
196162008964	Ligand binding site; other site
196162008965	Putative Catalytic site; other site
196162008966	DXD motif; other site
196162008967	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
196162008968	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
196162008969	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
196162008970	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196162008971	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
196162008972	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
196162008973	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
196162008974	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
196162008975	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162008976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162008977	S-adenosylmethionine binding site [chemical binding]; other site
196162008978	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196162008979	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162008980	Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513
196162008981	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
196162008982	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196162008983	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
196162008984	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
196162008985	DNA polymerase I; Provisional; Region: PRK05755
196162008986	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
196162008987	active site
196162008988	metal binding site 1 [ion binding]; metal-binding site
196162008989	putative 5' ssDNA interaction site; other site
196162008990	metal binding site 3; metal-binding site
196162008991	metal binding site 2 [ion binding]; metal-binding site
196162008992	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
196162008993	putative DNA binding site [nucleotide binding]; other site
196162008994	putative metal binding site [ion binding]; other site
196162008995	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
196162008996	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
196162008997	active site
196162008998	DNA binding site [nucleotide binding]
196162008999	catalytic site [active]
196162009000	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
196162009001	CoenzymeA binding site [chemical binding]; other site
196162009002	subunit interaction site [polypeptide binding]; other site
196162009003	PHB binding site; other site
196162009004	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
196162009005	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162009006	Coenzyme A binding pocket [chemical binding]; other site
196162009007	Protein of unknown function (DUF554); Region: DUF554; pfam04474
196162009008	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196162009009	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
196162009010	substrate binding pocket [chemical binding]; other site
196162009011	membrane-bound complex binding site; other site
196162009012	hinge residues; other site
196162009013	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
196162009014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162009015	dimer interface [polypeptide binding]; other site
196162009016	conserved gate region; other site
196162009017	putative PBP binding loops; other site
196162009018	ABC-ATPase subunit interface; other site
196162009019	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
196162009020	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
196162009021	Walker A/P-loop; other site
196162009022	ATP binding site [chemical binding]; other site
196162009023	Q-loop/lid; other site
196162009024	ABC transporter signature motif; other site
196162009025	Walker B; other site
196162009026	D-loop; other site
196162009027	H-loop/switch region; other site
196162009028	MG2 domain; Region: A2M_N; pfam01835
196162009029	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162009030	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162009031	TM-ABC transporter signature motif; other site
196162009032	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162009033	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162009034	TM-ABC transporter signature motif; other site
196162009035	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162009036	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162009037	Walker A/P-loop; other site
196162009038	ATP binding site [chemical binding]; other site
196162009039	Q-loop/lid; other site
196162009040	ABC transporter signature motif; other site
196162009041	Walker B; other site
196162009042	D-loop; other site
196162009043	H-loop/switch region; other site
196162009044	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162009045	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162009046	Walker A/P-loop; other site
196162009047	ATP binding site [chemical binding]; other site
196162009048	Q-loop/lid; other site
196162009049	ABC transporter signature motif; other site
196162009050	Walker B; other site
196162009051	D-loop; other site
196162009052	H-loop/switch region; other site
196162009053	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
196162009054	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162009055	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
196162009056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162009057	active site
196162009058	phosphorylation site [posttranslational modification]
196162009059	intermolecular recognition site; other site
196162009060	dimerization interface [polypeptide binding]; other site
196162009061	ANTAR domain; Region: ANTAR; pfam03861
196162009062	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
196162009063	pyruvate kinase; Provisional; Region: PRK06247
196162009064	domain interfaces; other site
196162009065	active site
196162009066	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
196162009067	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162009068	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
196162009069	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
196162009070	active site
196162009071	dimer interface [polypeptide binding]; other site
196162009072	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
196162009073	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
196162009074	active site
196162009075	FMN binding site [chemical binding]; other site
196162009076	substrate binding site [chemical binding]; other site
196162009077	3Fe-4S cluster binding site [ion binding]; other site
196162009078	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
196162009079	domain interface; other site
196162009080	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
196162009081	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
196162009082	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
196162009083	Cu(I) binding site [ion binding]; other site
196162009084	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
196162009085	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
196162009086	substrate binding site [chemical binding]; other site
196162009087	active site
196162009088	catalytic residues [active]
196162009089	heterodimer interface [polypeptide binding]; other site
196162009090	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
196162009091	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
196162009092	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162009093	catalytic residue [active]
196162009094	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
196162009095	active site
196162009096	ribulose/triose binding site [chemical binding]; other site
196162009097	phosphate binding site [ion binding]; other site
196162009098	substrate (anthranilate) binding pocket [chemical binding]; other site
196162009099	product (indole) binding pocket [chemical binding]; other site
196162009100	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
196162009101	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
196162009102	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850
196162009103	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
196162009104	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162009105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162009106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162009107	Walker A/P-loop; other site
196162009108	ATP binding site [chemical binding]; other site
196162009109	Q-loop/lid; other site
196162009110	ABC transporter signature motif; other site
196162009111	Walker B; other site
196162009112	D-loop; other site
196162009113	H-loop/switch region; other site
196162009114	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
196162009115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
196162009116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162009117	Walker A/P-loop; other site
196162009118	ATP binding site [chemical binding]; other site
196162009119	Q-loop/lid; other site
196162009120	ABC transporter signature motif; other site
196162009121	Walker B; other site
196162009122	D-loop; other site
196162009123	H-loop/switch region; other site
196162009124	TIGR03085 family protein; Region: TIGR03085
196162009125	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
196162009126	DsrC like protein; Region: DsrC; pfam04358
196162009127	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
196162009128	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
196162009129	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
196162009130	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
196162009131	substrate binding site [chemical binding]; other site
196162009132	glutamase interaction surface [polypeptide binding]; other site
196162009133	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
196162009134	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
196162009135	catalytic residues [active]
196162009136	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
196162009137	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
196162009138	putative active site [active]
196162009139	oxyanion strand; other site
196162009140	catalytic triad [active]
196162009141	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
196162009142	putative active site pocket [active]
196162009143	4-fold oligomerization interface [polypeptide binding]; other site
196162009144	metal binding residues [ion binding]; metal-binding site
196162009145	3-fold/trimer interface [polypeptide binding]; other site
196162009146	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
196162009147	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162009148	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162009149	homodimer interface [polypeptide binding]; other site
196162009150	catalytic residue [active]
196162009151	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
196162009152	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
196162009153	NAD binding site [chemical binding]; other site
196162009154	dimerization interface [polypeptide binding]; other site
196162009155	product binding site; other site
196162009156	substrate binding site [chemical binding]; other site
196162009157	zinc binding site [ion binding]; other site
196162009158	catalytic residues [active]
196162009159	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
196162009160	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
196162009161	putative deacylase active site [active]
196162009162	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
196162009163	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
196162009164	active site
196162009165	PHP Thumb interface [polypeptide binding]; other site
196162009166	metal binding site [ion binding]; metal-binding site
196162009167	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
196162009168	generic binding surface II; other site
196162009169	generic binding surface I; other site
196162009170	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
196162009171	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162009172	Coenzyme A binding pocket [chemical binding]; other site
196162009173	Chorismate mutase type II; Region: CM_2; smart00830
196162009174	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
196162009175	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196162009176	RNA binding surface [nucleotide binding]; other site
196162009177	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
196162009178	active site
196162009179	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
196162009180	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
196162009181	DivIVA domain; Region: DivI1A_domain; TIGR03544
196162009182	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
196162009183	YGGT family; Region: YGGT; pfam02325
196162009184	Protein of unknown function (DUF552); Region: DUF552; pfam04472
196162009185	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
196162009186	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162009187	catalytic residue [active]
196162009188	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
196162009189	cell division protein FtsZ; Validated; Region: PRK09330
196162009190	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
196162009191	nucleotide binding site [chemical binding]; other site
196162009192	SulA interaction site; other site
196162009193	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
196162009194	Cell division protein FtsQ; Region: FtsQ; pfam03799
196162009195	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
196162009196	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
196162009197	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196162009198	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196162009199	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
196162009200	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
196162009201	active site
196162009202	homodimer interface [polypeptide binding]; other site
196162009203	cell division protein FtsW; Region: ftsW; TIGR02614
196162009204	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
196162009205	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196162009206	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
196162009207	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
196162009208	Mg++ binding site [ion binding]; other site
196162009209	putative catalytic motif [active]
196162009210	putative substrate binding site [chemical binding]; other site
196162009211	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
196162009212	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
196162009213	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196162009214	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
196162009215	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
196162009216	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196162009217	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196162009218	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
196162009219	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
196162009220	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196162009221	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
196162009222	MraW methylase family; Region: Methyltransf_5; cl17771
196162009223	cell division protein MraZ; Reviewed; Region: PRK00326
196162009224	MraZ protein; Region: MraZ; pfam02381
196162009225	MraZ protein; Region: MraZ; pfam02381
196162009226	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162009227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162009228	Walker A motif; other site
196162009229	ATP binding site [chemical binding]; other site
196162009230	Walker B motif; other site
196162009231	arginine finger; other site
196162009232	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
196162009233	Protein of unknown function DUF58; Region: DUF58; pfam01882
196162009234	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
196162009235	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
196162009236	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
196162009237	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162009238	S-adenosylmethionine binding site [chemical binding]; other site
196162009239	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
196162009240	putative deacylase active site [active]
196162009241	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162009242	ArsC family; Region: ArsC; pfam03960
196162009243	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
196162009244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162009245	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
196162009246	FAD binding site [chemical binding]; other site
196162009247	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
196162009248	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
196162009249	substrate binding pocket [chemical binding]; other site
196162009250	chain length determination region; other site
196162009251	substrate-Mg2+ binding site; other site
196162009252	catalytic residues [active]
196162009253	aspartate-rich region 1; other site
196162009254	active site lid residues [active]
196162009255	aspartate-rich region 2; other site
196162009256	Helix-turn-helix domain; Region: HTH_17; cl17695
196162009257	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162009258	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162009259	active site
196162009260	ATP binding site [chemical binding]; other site
196162009261	substrate binding site [chemical binding]; other site
196162009262	activation loop (A-loop); other site
196162009263	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
196162009264	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162009265	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162009266	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162009267	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162009268	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
196162009269	AP endonuclease family 2; Region: AP2Ec; smart00518
196162009270	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
196162009271	AP (apurinic/apyrimidinic) site pocket; other site
196162009272	DNA interaction; other site
196162009273	Metal-binding active site; metal-binding site
196162009274	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
196162009275	EamA-like transporter family; Region: EamA; pfam00892
196162009276	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
196162009277	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
196162009278	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
196162009279	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
196162009280	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
196162009281	tetramer interface [polypeptide binding]; other site
196162009282	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162009283	catalytic residue [active]
196162009284	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
196162009285	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
196162009286	amino acid transporter; Region: 2A0306; TIGR00909
196162009287	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
196162009288	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
196162009289	active site
196162009290	ADP/pyrophosphate binding site [chemical binding]; other site
196162009291	allosteric effector site; other site
196162009292	dimerization interface [polypeptide binding]; other site
196162009293	fructose-1,6-bisphosphate binding site; other site
196162009294	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162009295	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162009296	putative substrate translocation pore; other site
196162009297	Uncharacterized conserved protein [Function unknown]; Region: COG3342
196162009298	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
196162009299	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
196162009300	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
196162009301	N- and C-terminal domain interface [polypeptide binding]; other site
196162009302	active site
196162009303	MgATP binding site [chemical binding]; other site
196162009304	catalytic site [active]
196162009305	metal binding site [ion binding]; metal-binding site
196162009306	glycerol binding site [chemical binding]; other site
196162009307	homotetramer interface [polypeptide binding]; other site
196162009308	homodimer interface [polypeptide binding]; other site
196162009309	FBP binding site [chemical binding]; other site
196162009310	protein IIAGlc interface [polypeptide binding]; other site
196162009311	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
196162009312	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162009313	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196162009314	putative acyl-acceptor binding pocket; other site
196162009315	Esterase/lipase [General function prediction only]; Region: COG1647
196162009316	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162009317	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
196162009318	Uncharacterized conserved protein [Function unknown]; Region: COG1915
196162009319	homodimer interface [polypeptide binding]; other site
196162009320	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162009321	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162009322	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
196162009323	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196162009324	nucleotide binding site [chemical binding]; other site
196162009325	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
196162009326	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
196162009327	P loop; other site
196162009328	Nucleotide binding site [chemical binding]; other site
196162009329	DTAP/Switch II; other site
196162009330	Switch I; other site
196162009331	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
196162009332	putative hydrophobic ligand binding site [chemical binding]; other site
196162009333	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
196162009334	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
196162009335	acyl-activating enzyme (AAE) consensus motif; other site
196162009336	putative AMP binding site [chemical binding]; other site
196162009337	putative active site [active]
196162009338	putative CoA binding site [chemical binding]; other site
196162009339	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
196162009340	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
196162009341	AAA domain; Region: AAA_31; pfam13614
196162009342	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162009343	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
196162009344	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
196162009345	ATP binding site [chemical binding]; other site
196162009346	Walker A motif; other site
196162009347	hexamer interface [polypeptide binding]; other site
196162009348	Walker B motif; other site
196162009349	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
196162009350	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196162009351	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
196162009352	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
196162009353	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162009354	Histidine kinase; Region: HisKA_3; pfam07730
196162009355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162009356	ATP binding site [chemical binding]; other site
196162009357	Mg2+ binding site [ion binding]; other site
196162009358	G-X-G motif; other site
196162009359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162009360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162009361	active site
196162009362	phosphorylation site [posttranslational modification]
196162009363	intermolecular recognition site; other site
196162009364	dimerization interface [polypeptide binding]; other site
196162009365	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162009366	DNA binding residues [nucleotide binding]
196162009367	dimerization interface [polypeptide binding]; other site
196162009368	Peptidase family M48; Region: Peptidase_M48; cl12018
196162009369	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
196162009370	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
196162009371	NlpC/P60 family; Region: NLPC_P60; pfam00877
196162009372	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
196162009373	ydaO/yuaA element as predicted by Rfam (RF00379), score 52.21
196162009374	YacP-like NYN domain; Region: NYN_YacP; cl01491
196162009375	hypothetical protein; Validated; Region: PRK07883
196162009376	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
196162009377	active site
196162009378	catalytic site [active]
196162009379	substrate binding site [chemical binding]; other site
196162009380	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
196162009381	GIY-YIG motif/motif A; other site
196162009382	active site
196162009383	catalytic site [active]
196162009384	putative DNA binding site [nucleotide binding]; other site
196162009385	metal binding site [ion binding]; metal-binding site
196162009386	UvrB/uvrC motif; Region: UVR; pfam02151
196162009387	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162009388	AsnC family; Region: AsnC_trans_reg; pfam01037
196162009389	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
196162009390	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
196162009391	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
196162009392	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162009393	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
196162009394	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
196162009395	Subunit I/III interface [polypeptide binding]; other site
196162009396	Cytochrome c; Region: Cytochrom_C; pfam00034
196162009397	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
196162009398	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
196162009399	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
196162009400	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
196162009401	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
196162009402	iron-sulfur cluster [ion binding]; other site
196162009403	[2Fe-2S] cluster binding site [ion binding]; other site
196162009404	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
196162009405	intrachain domain interface; other site
196162009406	interchain domain interface [polypeptide binding]; other site
196162009407	heme bL binding site [chemical binding]; other site
196162009408	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
196162009409	heme bH binding site [chemical binding]; other site
196162009410	Qo binding site; other site
196162009411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
196162009412	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
196162009413	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
196162009414	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
196162009415	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
196162009416	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
196162009417	D-pathway; other site
196162009418	Putative ubiquinol binding site [chemical binding]; other site
196162009419	Low-spin heme (heme b) binding site [chemical binding]; other site
196162009420	Putative water exit pathway; other site
196162009421	Binuclear center (heme o3/CuB) [ion binding]; other site
196162009422	K-pathway; other site
196162009423	Putative proton exit pathway; other site
196162009424	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
196162009425	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
196162009426	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
196162009427	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162009428	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
196162009429	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162009430	catalytic residue [active]
196162009431	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
196162009432	CPxP  motif; other site
196162009433	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
196162009434	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196162009435	substrate binding site [chemical binding]; other site
196162009436	ATP binding site [chemical binding]; other site
196162009437	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
196162009438	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
196162009439	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196162009440	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162009441	Coenzyme A binding pocket [chemical binding]; other site
196162009442	quinolinate synthetase; Provisional; Region: PRK09375
196162009443	heat shock protein HtpX; Provisional; Region: PRK02391
196162009444	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
196162009445	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
196162009446	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162009447	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162009448	active site
196162009449	catalytic tetrad [active]
196162009450	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
196162009451	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
196162009452	FAD binding pocket [chemical binding]; other site
196162009453	FAD binding motif [chemical binding]; other site
196162009454	phosphate binding motif [ion binding]; other site
196162009455	beta-alpha-beta structure motif; other site
196162009456	NAD(p) ribose binding residues [chemical binding]; other site
196162009457	NAD binding pocket [chemical binding]; other site
196162009458	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
196162009459	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162009460	catalytic loop [active]
196162009461	iron binding site [ion binding]; other site
196162009462	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
196162009463	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
196162009464	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
196162009465	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
196162009466	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
196162009467	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
196162009468	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
196162009469	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162009470	Coenzyme A binding pocket [chemical binding]; other site
196162009471	AzlC protein; Region: AzlC; pfam03591
196162009472	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
196162009473	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
196162009474	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
196162009475	active site
196162009476	P-loop; other site
196162009477	phosphorylation site [posttranslational modification]
196162009478	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
196162009479	active site
196162009480	phosphorylation site [posttranslational modification]
196162009481	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162009482	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
196162009483	putative NAD(P) binding site [chemical binding]; other site
196162009484	catalytic Zn binding site [ion binding]; other site
196162009485	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
196162009486	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
196162009487	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
196162009488	active site
196162009489	Zn binding site [ion binding]; other site
196162009490	dihydrodipicolinate reductase; Provisional; Region: PRK00048
196162009491	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
196162009492	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
196162009493	Methyltransferase domain; Region: Methyltransf_18; pfam12847
196162009494	S-adenosylmethionine binding site [chemical binding]; other site
196162009495	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
196162009496	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
196162009497	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
196162009498	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162009499	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162009500	DNA binding residues [nucleotide binding]
196162009501	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
196162009502	Membrane protein of unknown function; Region: DUF360; cl00850
196162009503	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
196162009504	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
196162009505	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
196162009506	5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231
196162009507	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
196162009508	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
196162009509	oligomer interface [polypeptide binding]; other site
196162009510	RNA binding site [nucleotide binding]; other site
196162009511	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
196162009512	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
196162009513	RNase E interface [polypeptide binding]; other site
196162009514	trimer interface [polypeptide binding]; other site
196162009515	active site
196162009516	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
196162009517	putative nucleic acid binding region [nucleotide binding]; other site
196162009518	G-X-X-G motif; other site
196162009519	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
196162009520	RNA binding site [nucleotide binding]; other site
196162009521	domain interface; other site
196162009522	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
196162009523	16S/18S rRNA binding site [nucleotide binding]; other site
196162009524	S13e-L30e interaction site [polypeptide binding]; other site
196162009525	25S rRNA binding site [nucleotide binding]; other site
196162009526	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
196162009527	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
196162009528	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
196162009529	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
196162009530	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
196162009531	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
196162009532	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
196162009533	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196162009534	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
196162009535	putative substrate binding site [chemical binding]; other site
196162009536	putative ATP binding site [chemical binding]; other site
196162009537	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
196162009538	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
196162009539	active site
196162009540	phosphorylation site [posttranslational modification]
196162009541	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
196162009542	active site
196162009543	P-loop; other site
196162009544	phosphorylation site [posttranslational modification]
196162009545	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
196162009546	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
196162009547	dimerization domain swap beta strand [polypeptide binding]; other site
196162009548	regulatory protein interface [polypeptide binding]; other site
196162009549	active site
196162009550	regulatory phosphorylation site [posttranslational modification]; other site
196162009551	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
196162009552	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
196162009553	active site
196162009554	Riboflavin kinase; Region: Flavokinase; smart00904
196162009555	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
196162009556	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
196162009557	RNA binding site [nucleotide binding]; other site
196162009558	active site
196162009559	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
196162009560	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
196162009561	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
196162009562	translation initiation factor IF-2; Region: IF-2; TIGR00487
196162009563	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
196162009564	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
196162009565	G1 box; other site
196162009566	putative GEF interaction site [polypeptide binding]; other site
196162009567	GTP/Mg2+ binding site [chemical binding]; other site
196162009568	Switch I region; other site
196162009569	G2 box; other site
196162009570	G3 box; other site
196162009571	Switch II region; other site
196162009572	G4 box; other site
196162009573	G5 box; other site
196162009574	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
196162009575	Translation-initiation factor 2; Region: IF-2; pfam11987
196162009576	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
196162009577	Protein of unknown function (DUF448); Region: DUF448; pfam04296
196162009578	putative RNA binding cleft [nucleotide binding]; other site
196162009579	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
196162009580	NusA N-terminal domain; Region: NusA_N; pfam08529
196162009581	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
196162009582	RNA binding site [nucleotide binding]; other site
196162009583	homodimer interface [polypeptide binding]; other site
196162009584	NusA-like KH domain; Region: KH_5; pfam13184
196162009585	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
196162009586	G-X-X-G motif; other site
196162009587	Sm and related proteins; Region: Sm_like; cl00259
196162009588	ribosome maturation protein RimP; Reviewed; Region: PRK00092
196162009589	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
196162009590	putative oligomer interface [polypeptide binding]; other site
196162009591	putative RNA binding site [nucleotide binding]; other site
196162009592	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
196162009593	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162009594	motif II; other site
196162009595	prolyl-tRNA synthetase; Provisional; Region: PRK09194
196162009596	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
196162009597	dimer interface [polypeptide binding]; other site
196162009598	motif 1; other site
196162009599	active site
196162009600	motif 2; other site
196162009601	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
196162009602	putative deacylase active site [active]
196162009603	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196162009604	active site
196162009605	motif 3; other site
196162009606	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
196162009607	anticodon binding site; other site
196162009608	Predicted acetyltransferase [General function prediction only]; Region: COG3393
196162009609	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
196162009610	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162009611	Phosphoesterase family; Region: Phosphoesterase; pfam04185
196162009612	Phosphoesterase family; Region: Phosphoesterase; pfam04185
196162009613	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
196162009614	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
196162009615	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
196162009616	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
196162009617	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
196162009618	active site
196162009619	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
196162009620	protein binding site [polypeptide binding]; other site
196162009621	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
196162009622	putative substrate binding region [chemical binding]; other site
196162009623	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
196162009624	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
196162009625	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
196162009626	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
196162009627	4-aminobutyrate aminotransferase; Provisional; Region: PRK06058
196162009628	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162009629	inhibitor-cofactor binding pocket; inhibition site
196162009630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162009631	catalytic residue [active]
196162009632	Isochorismatase family; Region: Isochorismatase; pfam00857
196162009633	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
196162009634	catalytic triad [active]
196162009635	dimer interface [polypeptide binding]; other site
196162009636	conserved cis-peptide bond; other site
196162009637	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
196162009638	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_32; cd04691
196162009639	nudix motif; other site
196162009640	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
196162009641	active site
196162009642	NTP binding site [chemical binding]; other site
196162009643	metal binding triad [ion binding]; metal-binding site
196162009644	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
196162009645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162009646	dimer interface [polypeptide binding]; other site
196162009647	conserved gate region; other site
196162009648	putative PBP binding loops; other site
196162009649	ABC-ATPase subunit interface; other site
196162009650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162009651	ABC-ATPase subunit interface; other site
196162009652	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
196162009653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162009654	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
196162009655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162009656	Walker A/P-loop; other site
196162009657	ATP binding site [chemical binding]; other site
196162009658	Q-loop/lid; other site
196162009659	ABC transporter signature motif; other site
196162009660	Walker B; other site
196162009661	D-loop; other site
196162009662	H-loop/switch region; other site
196162009663	TOBE domain; Region: TOBE_2; pfam08402
196162009664	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
196162009665	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
196162009666	NodB motif; other site
196162009667	active site
196162009668	catalytic site [active]
196162009669	metal binding site [ion binding]; metal-binding site
196162009670	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162009671	active site
196162009672	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
196162009673	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
196162009674	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
196162009675	tetrameric interface [polypeptide binding]; other site
196162009676	NAD binding site [chemical binding]; other site
196162009677	catalytic residues [active]
196162009678	substrate binding site [chemical binding]; other site
196162009679	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
196162009680	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
196162009681	active site
196162009682	agmatinase; Region: agmatinase; TIGR01230
196162009683	Agmatinase-like family; Region: Agmatinase-like; cd09990
196162009684	active site
196162009685	oligomer interface [polypeptide binding]; other site
196162009686	Mn binding site [ion binding]; other site
196162009687	hypothetical protein; Provisional; Region: PRK06541
196162009688	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162009689	inhibitor-cofactor binding pocket; inhibition site
196162009690	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162009691	catalytic residue [active]
196162009692	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
196162009693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162009694	dimer interface [polypeptide binding]; other site
196162009695	conserved gate region; other site
196162009696	putative PBP binding loops; other site
196162009697	ABC-ATPase subunit interface; other site
196162009698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162009699	dimer interface [polypeptide binding]; other site
196162009700	conserved gate region; other site
196162009701	putative PBP binding loops; other site
196162009702	ABC-ATPase subunit interface; other site
196162009703	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
196162009704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162009705	Walker A/P-loop; other site
196162009706	ATP binding site [chemical binding]; other site
196162009707	Q-loop/lid; other site
196162009708	ABC transporter signature motif; other site
196162009709	Walker B; other site
196162009710	D-loop; other site
196162009711	H-loop/switch region; other site
196162009712	TOBE domain; Region: TOBE_2; pfam08402
196162009713	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
196162009714	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162009715	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162009716	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
196162009717	AsnC family; Region: AsnC_trans_reg; pfam01037
196162009718	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
196162009719	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162009720	Peptidase family M1; Region: Peptidase_M1; pfam01433
196162009721	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
196162009722	Zn binding site [ion binding]; other site
196162009723	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
196162009724	ATP binding site [chemical binding]; other site
196162009725	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
196162009726	metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; TIGR03767
196162009727	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162009728	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
196162009729	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
196162009730	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162009731	FeS/SAM binding site; other site
196162009732	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
196162009733	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
196162009734	ribosome recycling factor; Reviewed; Region: frr; PRK00083
196162009735	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
196162009736	hinge region; other site
196162009737	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
196162009738	putative nucleotide binding site [chemical binding]; other site
196162009739	uridine monophosphate binding site [chemical binding]; other site
196162009740	homohexameric interface [polypeptide binding]; other site
196162009741	elongation factor Ts; Provisional; Region: tsf; PRK09377
196162009742	UBA/TS-N domain; Region: UBA; pfam00627
196162009743	Elongation factor TS; Region: EF_TS; pfam00889
196162009744	Elongation factor TS; Region: EF_TS; pfam00889
196162009745	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
196162009746	rRNA interaction site [nucleotide binding]; other site
196162009747	S8 interaction site; other site
196162009748	putative laminin-1 binding site; other site
196162009749	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162009750	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162009751	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
196162009752	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162009753	active site
196162009754	DNA binding site [nucleotide binding]
196162009755	Int/Topo IB signature motif; other site
196162009756	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
196162009757	DNA protecting protein DprA; Region: dprA; TIGR00732
196162009758	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
196162009759	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
196162009760	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162009761	Walker A motif; other site
196162009762	ATP binding site [chemical binding]; other site
196162009763	Walker B motif; other site
196162009764	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
196162009765	hypothetical protein; Reviewed; Region: PRK12497
196162009766	Predicted membrane protein [Function unknown]; Region: COG4655
196162009767	TadE-like protein; Region: TadE; pfam07811
196162009768	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
196162009769	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
196162009770	RNA/DNA hybrid binding site [nucleotide binding]; other site
196162009771	active site
196162009772	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
196162009773	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
196162009774	Catalytic site [active]
196162009775	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
196162009776	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
196162009777	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
196162009778	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
196162009779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
196162009780	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
196162009781	RimM N-terminal domain; Region: RimM; pfam01782
196162009782	PRC-barrel domain; Region: PRC; pfam05239
196162009783	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196162009784	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162009785	hypothetical protein; Provisional; Region: PRK02821
196162009786	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
196162009787	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
196162009788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162009789	Response regulator receiver domain; Region: Response_reg; pfam00072
196162009790	active site
196162009791	phosphorylation site [posttranslational modification]
196162009792	intermolecular recognition site; other site
196162009793	dimerization interface [polypeptide binding]; other site
196162009794	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
196162009795	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162009796	active site
196162009797	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196162009798	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
196162009799	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
196162009800	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162009801	dimerization interface [polypeptide binding]; other site
196162009802	putative DNA binding site [nucleotide binding]; other site
196162009803	putative Zn2+ binding site [ion binding]; other site
196162009804	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162009805	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162009806	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162009807	signal recognition particle protein; Provisional; Region: PRK10867
196162009808	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
196162009809	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
196162009810	P loop; other site
196162009811	GTP binding site [chemical binding]; other site
196162009812	Signal peptide binding domain; Region: SRP_SPB; pfam02978
196162009813	PII uridylyl-transferase; Provisional; Region: PRK03381
196162009814	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
196162009815	metal binding triad; other site
196162009816	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
196162009817	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196162009818	Zn2+ binding site [ion binding]; other site
196162009819	Mg2+ binding site [ion binding]; other site
196162009820	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
196162009821	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
196162009822	Nitrogen regulatory protein P-II; Region: P-II; smart00938
196162009823	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
196162009824	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
196162009825	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
196162009826	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162009827	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
196162009828	active site
196162009829	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
196162009830	AAA domain; Region: AAA_23; pfam13476
196162009831	Walker A/P-loop; other site
196162009832	ATP binding site [chemical binding]; other site
196162009833	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
196162009834	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
196162009835	ABC transporter signature motif; other site
196162009836	Walker B; other site
196162009837	D-loop; other site
196162009838	H-loop/switch region; other site
196162009839	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
196162009840	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162009841	catalytic residue [active]
196162009842	Probable transposase; Region: OrfB_IS605; pfam01385
196162009843	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
196162009844	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
196162009845	Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909
196162009846	FAD binding domain; Region: FAD_binding_4; pfam01565
196162009847	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
196162009848	H+ Antiporter protein; Region: 2A0121; TIGR00900
196162009849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162009850	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
196162009851	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
196162009852	DNA binding site [nucleotide binding]
196162009853	catalytic residue [active]
196162009854	H2TH interface [polypeptide binding]; other site
196162009855	putative catalytic residues [active]
196162009856	turnover-facilitating residue; other site
196162009857	intercalation triad [nucleotide binding]; other site
196162009858	8OG recognition residue [nucleotide binding]; other site
196162009859	putative reading head residues; other site
196162009860	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196162009861	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
196162009862	ribonuclease III; Reviewed; Region: rnc; PRK00102
196162009863	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
196162009864	dimerization interface [polypeptide binding]; other site
196162009865	active site
196162009866	metal binding site [ion binding]; metal-binding site
196162009867	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
196162009868	dsRNA binding site [nucleotide binding]; other site
196162009869	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
196162009870	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
196162009871	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
196162009872	active site
196162009873	(T/H)XGH motif; other site
196162009874	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
196162009875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162009876	S-adenosylmethionine binding site [chemical binding]; other site
196162009877	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
196162009878	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
196162009879	generic binding surface II; other site
196162009880	ssDNA binding site; other site
196162009881	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162009882	ATP binding site [chemical binding]; other site
196162009883	putative Mg++ binding site [ion binding]; other site
196162009884	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162009885	nucleotide binding region [chemical binding]; other site
196162009886	ATP-binding site [chemical binding]; other site
196162009887	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
196162009888	DAK2 domain; Region: Dak2; pfam02734
196162009889	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
196162009890	thiamine monophosphate kinase; Provisional; Region: PRK05731
196162009891	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
196162009892	ATP binding site [chemical binding]; other site
196162009893	dimerization interface [polypeptide binding]; other site
196162009894	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162009895	AsnC family; Region: AsnC_trans_reg; pfam01037
196162009896	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
196162009897	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
196162009898	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
196162009899	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
196162009900	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
196162009901	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162009902	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162009903	catalytic residue [active]
196162009904	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
196162009905	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
196162009906	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
196162009907	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162009908	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196162009909	putative acyl-acceptor binding pocket; other site
196162009910	Guanylyl transferase CofC like; Region: CofC; cl17472
196162009911	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
196162009912	IHF - DNA interface [nucleotide binding]; other site
196162009913	IHF dimer interface [polypeptide binding]; other site
196162009914	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
196162009915	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
196162009916	substrate binding site [chemical binding]; other site
196162009917	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
196162009918	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
196162009919	substrate binding site [chemical binding]; other site
196162009920	ligand binding site [chemical binding]; other site
196162009921	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
196162009922	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162009923	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162009924	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
196162009925	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
196162009926	DNA binding site [nucleotide binding]
196162009927	active site
196162009928	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
196162009929	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
196162009930	AlkA N-terminal domain; Region: AlkA_N; pfam06029
196162009931	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
196162009932	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
196162009933	minor groove reading motif; other site
196162009934	helix-hairpin-helix signature motif; other site
196162009935	substrate binding pocket [chemical binding]; other site
196162009936	active site
196162009937	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
196162009938	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
196162009939	Sodium Bile acid symporter family; Region: SBF; cl17470
196162009940	short chain dehydrogenase; Provisional; Region: PRK06181
196162009941	classical (c) SDRs; Region: SDR_c; cd05233
196162009942	NAD(P) binding site [chemical binding]; other site
196162009943	active site
196162009944	UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240
196162009945	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
196162009946	putative NAD(P) binding site [chemical binding]; other site
196162009947	active site
196162009948	putative substrate binding site [chemical binding]; other site
196162009949	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
196162009950	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196162009951	PYR/PP interface [polypeptide binding]; other site
196162009952	dimer interface [polypeptide binding]; other site
196162009953	TPP binding site [chemical binding]; other site
196162009954	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196162009955	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
196162009956	TPP-binding site; other site
196162009957	dimer interface [polypeptide binding]; other site
196162009958	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162009959	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196162009960	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196162009961	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
196162009962	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196162009963	Zn2+ binding site [ion binding]; other site
196162009964	Mg2+ binding site [ion binding]; other site
196162009965	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162009966	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162009967	DNA binding residues [nucleotide binding]
196162009968	dimerization interface [polypeptide binding]; other site
196162009969	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
196162009970	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
196162009971	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
196162009972	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
196162009973	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
196162009974	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
196162009975	N- and C-terminal domain interface [polypeptide binding]; other site
196162009976	putative active site [active]
196162009977	MgATP binding site [chemical binding]; other site
196162009978	catalytic site [active]
196162009979	metal binding site [ion binding]; metal-binding site
196162009980	putative xylulose binding site [chemical binding]; other site
196162009981	putative homodimer interface [polypeptide binding]; other site
196162009982	BtpA family; Region: BtpA; cl00440
196162009983	DAK2 domain; Region: Dak2; pfam02734
196162009984	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
196162009985	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
196162009986	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162009987	TM-ABC transporter signature motif; other site
196162009988	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
196162009989	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162009990	TM-ABC transporter signature motif; other site
196162009991	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
196162009992	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162009993	Walker A/P-loop; other site
196162009994	ATP binding site [chemical binding]; other site
196162009995	Q-loop/lid; other site
196162009996	ABC transporter signature motif; other site
196162009997	Walker B; other site
196162009998	D-loop; other site
196162009999	H-loop/switch region; other site
196162010000	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162010001	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
196162010002	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
196162010003	ligand binding site [chemical binding]; other site
196162010004	DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434
196162010005	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
196162010006	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196162010007	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
196162010008	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
196162010009	putative NAD(P) binding site [chemical binding]; other site
196162010010	putative substrate binding site [chemical binding]; other site
196162010011	catalytic Zn binding site [ion binding]; other site
196162010012	structural Zn binding site [ion binding]; other site
196162010013	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
196162010014	active site
196162010015	catalytic triad [active]
196162010016	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
196162010017	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
196162010018	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
196162010019	oligomeric interface; other site
196162010020	putative active site [active]
196162010021	homodimer interface [polypeptide binding]; other site
196162010022	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
196162010023	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162010024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162010025	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196162010026	S-adenosylmethionine binding site [chemical binding]; other site
196162010027	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162010028	non-specific DNA binding site [nucleotide binding]; other site
196162010029	salt bridge; other site
196162010030	sequence-specific DNA binding site [nucleotide binding]; other site
196162010031	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
196162010032	DNA binding site [nucleotide binding]
196162010033	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
196162010034	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
196162010035	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
196162010036	active site
196162010037	HIGH motif; other site
196162010038	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
196162010039	active site
196162010040	KMSKS motif; other site
196162010041	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
196162010042	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
196162010043	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196162010044	Penicillin amidase; Region: Penicil_amidase; pfam01804
196162010045	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
196162010046	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
196162010047	active site
196162010048	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
196162010049	MOSC domain; Region: MOSC; pfam03473
196162010050	CoA binding domain; Region: CoA_binding_2; pfam13380
196162010051	Excalibur calcium-binding domain; Region: Excalibur; cl05460
196162010052	Dienelactone hydrolase family; Region: DLH; pfam01738
196162010053	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
196162010054	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162010055	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162010056	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
196162010057	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
196162010058	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
196162010059	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
196162010060	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
196162010061	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
196162010062	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162010063	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
196162010064	BioY family; Region: BioY; pfam02632
196162010065	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196162010066	Walker A/P-loop; other site
196162010067	ATP binding site [chemical binding]; other site
196162010068	ABC transporter; Region: ABC_tran; pfam00005
196162010069	Q-loop/lid; other site
196162010070	ABC transporter signature motif; other site
196162010071	Walker B; other site
196162010072	D-loop; other site
196162010073	H-loop/switch region; other site
196162010074	Cobalt transport protein; Region: CbiQ; cl00463
196162010075	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162010076	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
196162010077	GTP cyclohydrolase I; Provisional; Region: PLN03044
196162010078	active site
196162010079	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
196162010080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162010081	classical (c) SDRs; Region: SDR_c; cd05233
196162010082	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
196162010083	NAD(P) binding site [chemical binding]; other site
196162010084	active site
196162010085	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162010086	Coenzyme A binding pocket [chemical binding]; other site
196162010087	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
196162010088	Amidase; Region: Amidase; cl11426
196162010089	Predicted flavoprotein [General function prediction only]; Region: COG0431
196162010090	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196162010091	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162010092	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
196162010093	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162010094	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162010095	catalytic residue [active]
196162010096	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
196162010097	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
196162010098	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
196162010099	metal binding site [ion binding]; metal-binding site
196162010100	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
196162010101	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
196162010102	active site
196162010103	catalytic residues [active]
196162010104	metal binding site [ion binding]; metal-binding site
196162010105	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
196162010106	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162010107	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162010108	active site
196162010109	ATP binding site [chemical binding]; other site
196162010110	substrate binding site [chemical binding]; other site
196162010111	activation loop (A-loop); other site
196162010112	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
196162010113	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
196162010114	homodimer interface [polypeptide binding]; other site
196162010115	substrate-cofactor binding pocket; other site
196162010116	catalytic residue [active]
196162010117	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
196162010118	tartrate dehydrogenase; Region: TTC; TIGR02089
196162010119	Methyltransferase domain; Region: Methyltransf_24; pfam13578
196162010120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162010121	S-adenosylmethionine binding site [chemical binding]; other site
196162010122	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
196162010123	Predicted membrane protein [Function unknown]; Region: COG2364
196162010124	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
196162010125	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162010126	DNA-binding site [nucleotide binding]; DNA binding site
196162010127	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162010128	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162010129	homodimer interface [polypeptide binding]; other site
196162010130	catalytic residue [active]
196162010131	MarR family; Region: MarR_2; pfam12802
196162010132	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
196162010133	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
196162010134	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162010135	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162010136	FAD binding domain; Region: FAD_binding_4; pfam01565
196162010137	Berberine and berberine like; Region: BBE; pfam08031
196162010138	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196162010139	FMN binding site [chemical binding]; other site
196162010140	substrate binding site [chemical binding]; other site
196162010141	putative catalytic residue [active]
196162010142	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
196162010143	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162010144	permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428
196162010145	classical (c) SDRs; Region: SDR_c; cd05233
196162010146	NAD(P) binding site [chemical binding]; other site
196162010147	active site
196162010148	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
196162010149	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162010150	NAD(P) binding site [chemical binding]; other site
196162010151	active site
196162010152	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
196162010153	oligomer interface [polypeptide binding]; other site
196162010154	putative active site [active]
196162010155	Mn binding site [ion binding]; other site
196162010156	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
196162010157	Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938
196162010158	active site
196162010159	catalytic site [active]
196162010160	Zn binding site [ion binding]; other site
196162010161	tetramer interface [polypeptide binding]; other site
196162010162	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196162010163	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
196162010164	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
196162010165	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
196162010166	ligand binding site [chemical binding]; other site
196162010167	NAD binding site [chemical binding]; other site
196162010168	dimerization interface [polypeptide binding]; other site
196162010169	catalytic site [active]
196162010170	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
196162010171	putative L-serine binding site [chemical binding]; other site
196162010172	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196162010173	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162010174	Walker A/P-loop; other site
196162010175	ATP binding site [chemical binding]; other site
196162010176	Q-loop/lid; other site
196162010177	ABC transporter signature motif; other site
196162010178	Walker B; other site
196162010179	D-loop; other site
196162010180	H-loop/switch region; other site
196162010181	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162010182	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
196162010183	Iron permease FTR1 family; Region: FTR1; pfam03239
196162010184	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
196162010185	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
196162010186	catalytic residues [active]
196162010187	ketol-acid reductoisomerase; Provisional; Region: PRK05479
196162010188	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
196162010189	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
196162010190	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
196162010191	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
196162010192	putative valine binding site [chemical binding]; other site
196162010193	dimer interface [polypeptide binding]; other site
196162010194	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
196162010195	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
196162010196	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
196162010197	PYR/PP interface [polypeptide binding]; other site
196162010198	dimer interface [polypeptide binding]; other site
196162010199	TPP binding site [chemical binding]; other site
196162010200	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196162010201	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
196162010202	TPP-binding site [chemical binding]; other site
196162010203	dimer interface [polypeptide binding]; other site
196162010204	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
196162010205	aromatic arch; other site
196162010206	DCoH dimer interaction site [polypeptide binding]; other site
196162010207	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
196162010208	DCoH tetramer interaction site [polypeptide binding]; other site
196162010209	substrate binding site [chemical binding]; other site
196162010210	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162010211	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
196162010212	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
196162010213	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162010214	kynureninase; Region: kynureninase; TIGR01814
196162010215	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162010216	catalytic residue [active]
196162010217	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162010218	D-xylulose kinase; Region: XylB; TIGR01312
196162010219	nucleotide binding site [chemical binding]; other site
196162010220	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
196162010221	active site
196162010222	catalytic residues [active]
196162010223	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
196162010224	ThiC-associated domain; Region: ThiC-associated; pfam13667
196162010225	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
196162010226	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
196162010227	dimer interface [polypeptide binding]; other site
196162010228	substrate binding site [chemical binding]; other site
196162010229	ATP binding site [chemical binding]; other site
196162010230	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
196162010231	thiamine phosphate binding site [chemical binding]; other site
196162010232	active site
196162010233	pyrophosphate binding site [ion binding]; other site
196162010234	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
196162010235	ThiS interaction site; other site
196162010236	putative active site [active]
196162010237	tetramer interface [polypeptide binding]; other site
196162010238	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
196162010239	thiS-thiF/thiG interaction site; other site
196162010240	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162010241	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
196162010242	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
196162010243	thiamine phosphate binding site [chemical binding]; other site
196162010244	active site
196162010245	pyrophosphate binding site [ion binding]; other site
196162010246	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
196162010247	putative FMN binding site [chemical binding]; other site
196162010248	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
196162010249	active site
196162010250	homodimer interface [polypeptide binding]; other site
196162010251	SAM binding site [chemical binding]; other site
196162010252	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
196162010253	active site
196162010254	SAM binding site [chemical binding]; other site
196162010255	homodimer interface [polypeptide binding]; other site
196162010256	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
196162010257	active site
196162010258	SAM binding site [chemical binding]; other site
196162010259	homodimer interface [polypeptide binding]; other site
196162010260	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
196162010261	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
196162010262	precorrin-3B synthase; Region: CobG; TIGR02435
196162010263	AAA domain; Region: AAA_26; pfam13500
196162010264	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
196162010265	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
196162010266	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
196162010267	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162010268	catalytic residue [active]
196162010269	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162010270	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
196162010271	inhibitor-cofactor binding pocket; inhibition site
196162010272	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162010273	catalytic residue [active]
196162010274	biotin synthase; Validated; Region: PRK06256
196162010275	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162010276	FeS/SAM binding site; other site
196162010277	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
196162010278	Berberine and berberine like; Region: BBE; pfam08031
196162010279	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
196162010280	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
196162010281	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
196162010282	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
196162010283	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
196162010284	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
196162010285	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
196162010286	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
196162010287	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
196162010288	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
196162010289	putative hydrophobic ligand binding site [chemical binding]; other site
196162010290	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
196162010291	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
196162010292	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162010293	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162010294	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
196162010295	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
196162010296	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196162010297	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
196162010298	Walker A/P-loop; other site
196162010299	ATP binding site [chemical binding]; other site
196162010300	Q-loop/lid; other site
196162010301	ABC transporter signature motif; other site
196162010302	Walker B; other site
196162010303	D-loop; other site
196162010304	H-loop/switch region; other site
196162010305	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
196162010306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162010307	Walker A/P-loop; other site
196162010308	ATP binding site [chemical binding]; other site
196162010309	Q-loop/lid; other site
196162010310	ABC transporter signature motif; other site
196162010311	Walker B; other site
196162010312	D-loop; other site
196162010313	H-loop/switch region; other site
196162010314	Cobalt transport protein; Region: CbiQ; cl00463
196162010315	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196162010316	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196162010317	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
196162010318	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
196162010319	GatB domain; Region: GatB_Yqey; smart00845
196162010320	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
196162010321	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
196162010322	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
196162010323	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
196162010324	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162010325	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162010326	catalytic residue [active]
196162010327	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
196162010328	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
196162010329	nucleotide binding pocket [chemical binding]; other site
196162010330	K-X-D-G motif; other site
196162010331	catalytic site [active]
196162010332	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
196162010333	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
196162010334	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
196162010335	Dimer interface [polypeptide binding]; other site
196162010336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162010337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162010338	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162010339	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
196162010340	intracellular protease, PfpI family; Region: PfpI; TIGR01382
196162010341	proposed catalytic triad [active]
196162010342	conserved cys residue [active]
196162010343	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
196162010344	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
196162010345	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
196162010346	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
196162010347	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
196162010348	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162010349	catalytic residue [active]
196162010350	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
196162010351	putative catalytic site [active]
196162010352	putative phosphate binding site [ion binding]; other site
196162010353	putative metal binding site [ion binding]; other site
196162010354	gamma-glutamyl kinase; Provisional; Region: PRK05429
196162010355	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
196162010356	nucleotide binding site [chemical binding]; other site
196162010357	homotetrameric interface [polypeptide binding]; other site
196162010358	putative phosphate binding site [ion binding]; other site
196162010359	putative allosteric binding site; other site
196162010360	PUA domain; Region: PUA; pfam01472
196162010361	GTPase CgtA; Reviewed; Region: obgE; PRK12296
196162010362	GTP1/OBG; Region: GTP1_OBG; pfam01018
196162010363	Obg GTPase; Region: Obg; cd01898
196162010364	G1 box; other site
196162010365	GTP/Mg2+ binding site [chemical binding]; other site
196162010366	Switch I region; other site
196162010367	G2 box; other site
196162010368	G3 box; other site
196162010369	Switch II region; other site
196162010370	G4 box; other site
196162010371	G5 box; other site
196162010372	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
196162010373	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
196162010374	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
196162010375	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
196162010376	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
196162010377	homodimer interface [polypeptide binding]; other site
196162010378	oligonucleotide binding site [chemical binding]; other site
196162010379	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
196162010380	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
196162010381	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
196162010382	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
196162010383	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
196162010384	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
196162010385	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
196162010386	dimer interface [polypeptide binding]; other site
196162010387	ADP-ribose binding site [chemical binding]; other site
196162010388	active site
196162010389	nudix motif; other site
196162010390	metal binding site [ion binding]; metal-binding site
196162010391	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
196162010392	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
196162010393	B12 binding site [chemical binding]; other site
196162010394	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162010395	FeS/SAM binding site; other site
196162010396	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
196162010397	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
196162010398	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
196162010399	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
196162010400	rod shape-determining protein MreD; Region: MreD; cl01087
196162010401	rod shape-determining protein MreC; Provisional; Region: PRK13922
196162010402	rod shape-determining protein MreC; Region: MreC; pfam04085
196162010403	rod shape-determining protein MreB; Provisional; Region: PRK13927
196162010404	MreB and similar proteins; Region: MreB_like; cd10225
196162010405	nucleotide binding site [chemical binding]; other site
196162010406	Mg binding site [ion binding]; other site
196162010407	putative protofilament interaction site [polypeptide binding]; other site
196162010408	RodZ interaction site [polypeptide binding]; other site
196162010409	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
196162010410	active site
196162010411	multimer interface [polypeptide binding]; other site
196162010412	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
196162010413	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
196162010414	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162010415	DNA-binding site [nucleotide binding]; DNA binding site
196162010416	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162010417	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162010418	homodimer interface [polypeptide binding]; other site
196162010419	catalytic residue [active]
196162010420	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
196162010421	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
196162010422	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
196162010423	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
196162010424	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
196162010425	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
196162010426	catalytic Zn binding site [ion binding]; other site
196162010427	NAD binding site [chemical binding]; other site
196162010428	structural Zn binding site [ion binding]; other site
196162010429	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196162010430	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
196162010431	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162010432	active site
196162010433	HIGH motif; other site
196162010434	nucleotide binding site [chemical binding]; other site
196162010435	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162010436	active site
196162010437	KMSKS motif; other site
196162010438	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
196162010439	tRNA binding surface [nucleotide binding]; other site
196162010440	anticodon binding site; other site
196162010441	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
196162010442	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
196162010443	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
196162010444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162010445	Walker A motif; other site
196162010446	ATP binding site [chemical binding]; other site
196162010447	Walker B motif; other site
196162010448	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
196162010449	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
196162010450	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
196162010451	oligomer interface [polypeptide binding]; other site
196162010452	active site residues [active]
196162010453	Clp protease; Region: CLP_protease; pfam00574
196162010454	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
196162010455	oligomer interface [polypeptide binding]; other site
196162010456	active site residues [active]
196162010457	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
196162010458	hydrophobic ligand binding site; other site
196162010459	PGAP1-like protein; Region: PGAP1; pfam07819
196162010460	trigger factor; Provisional; Region: tig; PRK01490
196162010461	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
196162010462	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
196162010463	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
196162010464	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
196162010465	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
196162010466	putative DNA binding site [nucleotide binding]; other site
196162010467	catalytic residue [active]
196162010468	putative H2TH interface [polypeptide binding]; other site
196162010469	putative catalytic residues [active]
196162010470	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
196162010471	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
196162010472	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
196162010473	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
196162010474	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162010475	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
196162010476	alanine racemase; Reviewed; Region: alr; PRK00053
196162010477	active site
196162010478	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162010479	dimer interface [polypeptide binding]; other site
196162010480	substrate binding site [chemical binding]; other site
196162010481	catalytic residues [active]
196162010482	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
196162010483	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
196162010484	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162010485	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162010486	Histidine kinase; Region: HisKA_3; pfam07730
196162010487	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196162010488	ATP binding site [chemical binding]; other site
196162010489	Mg2+ binding site [ion binding]; other site
196162010490	G-X-G motif; other site
196162010491	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162010492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010493	active site
196162010494	phosphorylation site [posttranslational modification]
196162010495	intermolecular recognition site; other site
196162010496	dimerization interface [polypeptide binding]; other site
196162010497	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162010498	DNA binding residues [nucleotide binding]
196162010499	dimerization interface [polypeptide binding]; other site
196162010500	AIR carboxylase; Region: AIRC; pfam00731
196162010501	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
196162010502	ATP-grasp domain; Region: ATP-grasp; pfam02222
196162010503	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162010504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162010505	DNA binding site [nucleotide binding]
196162010506	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
196162010507	cyclase homology domain; Region: CHD; cd07302
196162010508	nucleotidyl binding site; other site
196162010509	metal binding site [ion binding]; metal-binding site
196162010510	dimer interface [polypeptide binding]; other site
196162010511	Bacterial PH domain; Region: DUF304; pfam03703
196162010512	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
196162010513	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
196162010514	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
196162010515	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
196162010516	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196162010517	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196162010518	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
196162010519	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
196162010520	DXD motif; other site
196162010521	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162010522	active site
196162010523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010524	Response regulator receiver domain; Region: Response_reg; pfam00072
196162010525	active site
196162010526	phosphorylation site [posttranslational modification]
196162010527	intermolecular recognition site; other site
196162010528	dimerization interface [polypeptide binding]; other site
196162010529	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162010530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162010531	DNA binding site [nucleotide binding]
196162010532	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
196162010533	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196162010534	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162010535	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162010536	Maf-like protein; Region: Maf; pfam02545
196162010537	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
196162010538	active site
196162010539	dimer interface [polypeptide binding]; other site
196162010540	Predicted membrane protein [Function unknown]; Region: COG2246
196162010541	GtrA-like protein; Region: GtrA; pfam04138
196162010542	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162010543	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162010544	active site
196162010545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162010546	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162010547	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
196162010548	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
196162010549	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196162010550	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
196162010551	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
196162010552	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162010553	carboxyltransferase (CT) interaction site; other site
196162010554	biotinylation site [posttranslational modification]; other site
196162010555	Bacterial PH domain; Region: DUF304; cl01348
196162010556	Bacterial PH domain; Region: DUF304; pfam03703
196162010557	Bacterial PH domain; Region: DUF304; pfam03703
196162010558	pyruvate carboxylase; Reviewed; Region: PRK12999
196162010559	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196162010560	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162010561	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
196162010562	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
196162010563	active site
196162010564	catalytic residues [active]
196162010565	metal binding site [ion binding]; metal-binding site
196162010566	homodimer binding site [polypeptide binding]; other site
196162010567	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162010568	carboxyltransferase (CT) interaction site; other site
196162010569	biotinylation site [posttranslational modification]; other site
196162010570	benzoate transporter; Region: benE; TIGR00843
196162010571	Stage II sporulation protein; Region: SpoIID; pfam08486
196162010572	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
196162010573	Stage II sporulation protein; Region: SpoIID; pfam08486
196162010574	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
196162010575	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
196162010576	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
196162010577	NAD binding site [chemical binding]; other site
196162010578	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162010579	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162010580	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
196162010581	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162010582	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
196162010583	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
196162010584	dimerization interface [polypeptide binding]; other site
196162010585	putative active site pocket [active]
196162010586	putative catalytic residue [active]
196162010587	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
196162010588	purine nucleoside phosphorylase; Provisional; Region: PRK08202
196162010589	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162010590	extended (e) SDRs; Region: SDR_e; cd08946
196162010591	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162010592	NAD(P) binding site [chemical binding]; other site
196162010593	substrate binding site [chemical binding]; other site
196162010594	active site
196162010595	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162010596	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162010597	active site
196162010598	catalytic tetrad [active]
196162010599	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824
196162010600	putative hydrophobic ligand binding site [chemical binding]; other site
196162010601	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
196162010602	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
196162010603	active site
196162010604	substrate binding site [chemical binding]; other site
196162010605	metal binding site [ion binding]; metal-binding site
196162010606	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
196162010607	intersubunit interface [polypeptide binding]; other site
196162010608	active site
196162010609	catalytic residue [active]
196162010610	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
196162010611	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162010612	NAD(P) binding site [chemical binding]; other site
196162010613	catalytic residues [active]
196162010614	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162010615	NAD(P) binding site [chemical binding]; other site
196162010616	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
196162010617	active site
196162010618	adenosine deaminase; Provisional; Region: PRK09358
196162010619	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
196162010620	active site
196162010621	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
196162010622	putative active site [active]
196162010623	putative catalytic site [active]
196162010624	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
196162010625	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
196162010626	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
196162010627	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
196162010628	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162010629	Cytochrome P450; Region: p450; cl12078
196162010630	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
196162010631	active site
196162010632	catalytic motif [active]
196162010633	Zn binding site [ion binding]; other site
196162010634	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162010635	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162010636	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162010637	TM-ABC transporter signature motif; other site
196162010638	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162010639	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162010640	TM-ABC transporter signature motif; other site
196162010641	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
196162010642	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162010643	Walker A/P-loop; other site
196162010644	ATP binding site [chemical binding]; other site
196162010645	Q-loop/lid; other site
196162010646	ABC transporter signature motif; other site
196162010647	Walker B; other site
196162010648	D-loop; other site
196162010649	H-loop/switch region; other site
196162010650	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162010651	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
196162010652	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
196162010653	ligand binding site [chemical binding]; other site
196162010654	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
196162010655	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
196162010656	metal binding site [ion binding]; metal-binding site
196162010657	putative dimer interface [polypeptide binding]; other site
196162010658	membrane ATPase/protein kinase; Provisional; Region: PRK09435
196162010659	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
196162010660	GTP/Mg2+ binding site [chemical binding]; other site
196162010661	G5 box; other site
196162010662	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
196162010663	Walker A; other site
196162010664	G1 box; other site
196162010665	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
196162010666	Switch II region; other site
196162010667	G4 box; other site
196162010668	G5 box; other site
196162010669	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
196162010670	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
196162010671	active site
196162010672	substrate binding site [chemical binding]; other site
196162010673	coenzyme B12 binding site [chemical binding]; other site
196162010674	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
196162010675	B12 binding site [chemical binding]; other site
196162010676	cobalt ligand [ion binding]; other site
196162010677	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
196162010678	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
196162010679	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
196162010680	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
196162010681	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162010682	catalytic loop [active]
196162010683	iron binding site [ion binding]; other site
196162010684	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
196162010685	L-aspartate oxidase; Provisional; Region: PRK06175
196162010686	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
196162010687	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162010688	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
196162010689	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
196162010690	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
196162010691	putative Iron-sulfur protein interface [polypeptide binding]; other site
196162010692	proximal heme binding site [chemical binding]; other site
196162010693	distal heme binding site [chemical binding]; other site
196162010694	putative dimer interface [polypeptide binding]; other site
196162010695	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
196162010696	L-aspartate oxidase; Provisional; Region: PRK06175
196162010697	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
196162010698	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
196162010699	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
196162010700	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
196162010701	TIGR03032 family protein; Region: TIGR03032
196162010702	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
196162010703	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
196162010704	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
196162010705	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
196162010706	active site
196162010707	HIGH motif; other site
196162010708	dimer interface [polypeptide binding]; other site
196162010709	KMSKS motif; other site
196162010710	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
196162010711	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162010712	MFS transport protein AraJ; Provisional; Region: PRK10091
196162010713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162010714	putative substrate translocation pore; other site
196162010715	short chain dehydrogenase; Provisional; Region: PRK07825
196162010716	classical (c) SDRs; Region: SDR_c; cd05233
196162010717	NAD(P) binding site [chemical binding]; other site
196162010718	active site
196162010719	Cytochrome P450; Region: p450; cl12078
196162010720	3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141
196162010721	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162010722	Integrase core domain; Region: rve; pfam00665
196162010723	Integrase core domain; Region: rve_3; pfam13683
196162010724	TIR domain; Region: TIR_2; pfam13676
196162010725	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
196162010726	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196162010727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162010728	non-specific DNA binding site [nucleotide binding]; other site
196162010729	salt bridge; other site
196162010730	sequence-specific DNA binding site [nucleotide binding]; other site
196162010731	Domain of unknown function (DUF955); Region: DUF955; cl01076
196162010732	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
196162010733	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
196162010734	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
196162010735	amphipathic channel; other site
196162010736	Asn-Pro-Ala signature motifs; other site
196162010737	malate dehydrogenase; Provisional; Region: PRK05442
196162010738	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
196162010739	NAD(P) binding site [chemical binding]; other site
196162010740	dimer interface [polypeptide binding]; other site
196162010741	malate binding site [chemical binding]; other site
196162010742	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
196162010743	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
196162010744	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
196162010745	Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; Region: THF_DHG_CYH_C; pfam02882
196162010746	NAD(P) binding pocket [chemical binding]; other site
196162010747	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
196162010748	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
196162010749	purine monophosphate binding site [chemical binding]; other site
196162010750	dimer interface [polypeptide binding]; other site
196162010751	putative catalytic residues [active]
196162010752	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
196162010753	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
196162010754	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
196162010755	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
196162010756	active site
196162010757	substrate binding site [chemical binding]; other site
196162010758	cosubstrate binding site; other site
196162010759	catalytic site [active]
196162010760	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
196162010761	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162010762	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162010763	DNA binding residues [nucleotide binding]
196162010764	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
196162010765	CoA binding domain; Region: CoA_binding; smart00881
196162010766	CoA-ligase; Region: Ligase_CoA; pfam00549
196162010767	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
196162010768	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
196162010769	CoA-ligase; Region: Ligase_CoA; pfam00549
196162010770	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
196162010771	B12 binding site [chemical binding]; other site
196162010772	cobalt ligand [ion binding]; other site
196162010773	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162010774	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162010775	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
196162010776	Part of AAA domain; Region: AAA_19; pfam13245
196162010777	Family description; Region: UvrD_C_2; pfam13538
196162010778	Response regulator receiver domain; Region: Response_reg; pfam00072
196162010779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010780	active site
196162010781	phosphorylation site [posttranslational modification]
196162010782	intermolecular recognition site; other site
196162010783	dimerization interface [polypeptide binding]; other site
196162010784	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
196162010785	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010786	Response regulator receiver domain; Region: Response_reg; pfam00072
196162010787	active site
196162010788	phosphorylation site [posttranslational modification]
196162010789	intermolecular recognition site; other site
196162010790	dimerization interface [polypeptide binding]; other site
196162010791	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
196162010792	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
196162010793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162010794	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
196162010795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010796	active site
196162010797	phosphorylation site [posttranslational modification]
196162010798	intermolecular recognition site; other site
196162010799	dimerization interface [polypeptide binding]; other site
196162010800	CheB methylesterase; Region: CheB_methylest; pfam01339
196162010801	HAMP domain; Region: HAMP; pfam00672
196162010802	dimerization interface [polypeptide binding]; other site
196162010803	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
196162010804	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
196162010805	dimer interface [polypeptide binding]; other site
196162010806	putative CheW interface [polypeptide binding]; other site
196162010807	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
196162010808	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
196162010809	putative binding surface; other site
196162010810	active site
196162010811	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
196162010812	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
196162010813	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162010814	ATP binding site [chemical binding]; other site
196162010815	Mg2+ binding site [ion binding]; other site
196162010816	G-X-G motif; other site
196162010817	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
196162010818	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
196162010819	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162010820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010821	active site
196162010822	phosphorylation site [posttranslational modification]
196162010823	intermolecular recognition site; other site
196162010824	dimerization interface [polypeptide binding]; other site
196162010825	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162010826	dimerization interface [polypeptide binding]; other site
196162010827	DNA binding residues [nucleotide binding]
196162010828	PspC domain; Region: PspC; pfam04024
196162010829	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162010830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162010831	ATP binding site [chemical binding]; other site
196162010832	Mg2+ binding site [ion binding]; other site
196162010833	G-X-G motif; other site
196162010834	PspC domain; Region: PspC; pfam04024
196162010835	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
196162010836	PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function.  The YbaK-like domain family includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939
196162010837	putative deacylase active site [active]
196162010838	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162010839	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
196162010840	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162010841	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162010842	active site
196162010843	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
196162010844	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162010845	NAD(P) binding site [chemical binding]; other site
196162010846	active site
196162010847	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162010848	active site
196162010849	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
196162010850	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
196162010851	acyl-activating enzyme (AAE) consensus motif; other site
196162010852	putative AMP binding site [chemical binding]; other site
196162010853	putative active site [active]
196162010854	putative CoA binding site [chemical binding]; other site
196162010855	MMPL family; Region: MMPL; pfam03176
196162010856	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
196162010857	FO synthase; Reviewed; Region: fbiC; PRK09234
196162010858	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162010859	FeS/SAM binding site; other site
196162010860	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162010861	FeS/SAM binding site; other site
196162010862	putative phosphoketolase; Provisional; Region: PRK05261
196162010863	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
196162010864	TPP-binding site; other site
196162010865	XFP C-terminal domain; Region: XFP_C; pfam09363
196162010866	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
196162010867	Fe-S cluster binding site [ion binding]; other site
196162010868	active site
196162010869	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
196162010870	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
196162010871	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162010872	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162010873	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
196162010874	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162010875	hydrophobic ligand binding site; other site
196162010876	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
196162010877	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
196162010878	homodimer interface [polypeptide binding]; other site
196162010879	substrate-cofactor binding pocket; other site
196162010880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162010881	catalytic residue [active]
196162010882	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
196162010883	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
196162010884	GMP synthase; Reviewed; Region: guaA; PRK00074
196162010885	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
196162010886	AMP/PPi binding site [chemical binding]; other site
196162010887	candidate oxyanion hole; other site
196162010888	catalytic triad [active]
196162010889	potential glutamine specificity residues [chemical binding]; other site
196162010890	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
196162010891	ATP Binding subdomain [chemical binding]; other site
196162010892	Ligand Binding sites [chemical binding]; other site
196162010893	Dimerization subdomain; other site
196162010894	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
196162010895	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
196162010896	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
196162010897	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
196162010898	NAD(P) binding site [chemical binding]; other site
196162010899	catalytic residues [active]
196162010900	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
196162010901	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162010902	NAD binding site [chemical binding]; other site
196162010903	catalytic residues [active]
196162010904	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
196162010905	putative active site [active]
196162010906	putative substrate binding site [chemical binding]; other site
196162010907	ATP binding site [chemical binding]; other site
196162010908	Phosphotransferase enzyme family; Region: APH; pfam01636
196162010909	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
196162010910	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
196162010911	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
196162010912	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
196162010913	putative active site [active]
196162010914	putative metal binding site [ion binding]; other site
196162010915	Predicted amidohydrolase [General function prediction only]; Region: COG0388
196162010916	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
196162010917	active site
196162010918	catalytic triad [active]
196162010919	dimer interface [polypeptide binding]; other site
196162010920	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
196162010921	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
196162010922	active site
196162010923	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
196162010924	Histidine kinase; Region: HisKA_3; pfam07730
196162010925	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162010926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162010927	active site
196162010928	phosphorylation site [posttranslational modification]
196162010929	intermolecular recognition site; other site
196162010930	dimerization interface [polypeptide binding]; other site
196162010931	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162010932	DNA binding residues [nucleotide binding]
196162010933	dimerization interface [polypeptide binding]; other site
196162010934	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
196162010935	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196162010936	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
196162010937	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
196162010938	active site
196162010939	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
196162010940	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
196162010941	ring oligomerisation interface [polypeptide binding]; other site
196162010942	ATP/Mg binding site [chemical binding]; other site
196162010943	stacking interactions; other site
196162010944	hinge regions; other site
196162010945	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
196162010946	oligomerisation interface [polypeptide binding]; other site
196162010947	mobile loop; other site
196162010948	roof hairpin; other site
196162010949	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
196162010950	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
196162010951	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
196162010952	NAD binding site [chemical binding]; other site
196162010953	catalytic Zn binding site [ion binding]; other site
196162010954	substrate binding site [chemical binding]; other site
196162010955	structural Zn binding site [ion binding]; other site
196162010956	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
196162010957	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196162010958	FMN binding site [chemical binding]; other site
196162010959	substrate binding site [chemical binding]; other site
196162010960	putative catalytic residue [active]
196162010961	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
196162010962	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162010963	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162010964	DNA binding residues [nucleotide binding]
196162010965	MMPL family; Region: MMPL; pfam03176
196162010966	MMPL family; Region: MMPL; pfam03176
196162010967	UGMP family protein; Validated; Region: PRK09604
196162010968	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
196162010969	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162010970	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162010971	putative DNA binding site [nucleotide binding]; other site
196162010972	putative Zn2+ binding site [ion binding]; other site
196162010973	AsnC family; Region: AsnC_trans_reg; pfam01037
196162010974	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
196162010975	Fic/DOC family; Region: Fic; cl00960
196162010976	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162010977	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
196162010978	Glycoprotease family; Region: Peptidase_M22; pfam00814
196162010979	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162010980	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162010981	DNA binding residues [nucleotide binding]
196162010982	dimerization interface [polypeptide binding]; other site
196162010983	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
196162010984	nucleotide binding site [chemical binding]; other site
196162010985	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
196162010986	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
196162010987	putative di-iron ligands [ion binding]; other site
196162010988	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
196162010989	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
196162010990	FAD binding pocket [chemical binding]; other site
196162010991	FAD binding motif [chemical binding]; other site
196162010992	phosphate binding motif [ion binding]; other site
196162010993	beta-alpha-beta structure motif; other site
196162010994	NAD binding pocket [chemical binding]; other site
196162010995	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162010996	catalytic loop [active]
196162010997	iron binding site [ion binding]; other site
196162010998	methionine sulfoxide reductase B; Provisional; Region: PRK00222
196162010999	SelR domain; Region: SelR; pfam01641
196162011000	Chlorite dismutase; Region: Chlor_dismutase; pfam06778
196162011001	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
196162011002	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162011003	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
196162011004	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
196162011005	substrate binding site [chemical binding]; other site
196162011006	active site
196162011007	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
196162011008	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
196162011009	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
196162011010	catalytic site [active]
196162011011	putative active site [active]
196162011012	putative substrate binding site [chemical binding]; other site
196162011013	HRDC domain; Region: HRDC; pfam00570
196162011014	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
196162011015	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
196162011016	active site
196162011017	dimerization interface [polypeptide binding]; other site
196162011018	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
196162011019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
196162011020	Walker A/P-loop; other site
196162011021	ATP binding site [chemical binding]; other site
196162011022	Q-loop/lid; other site
196162011023	ABC transporter signature motif; other site
196162011024	Walker B; other site
196162011025	D-loop; other site
196162011026	H-loop/switch region; other site
196162011027	TOBE domain; Region: TOBE_2; pfam08402
196162011028	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162011029	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162011030	dimer interface [polypeptide binding]; other site
196162011031	conserved gate region; other site
196162011032	putative PBP binding loops; other site
196162011033	ABC-ATPase subunit interface; other site
196162011034	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162011035	dimer interface [polypeptide binding]; other site
196162011036	conserved gate region; other site
196162011037	putative PBP binding loops; other site
196162011038	ABC-ATPase subunit interface; other site
196162011039	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196162011040	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196162011041	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162011042	classical (c) SDRs; Region: SDR_c; cd05233
196162011043	NAD(P) binding site [chemical binding]; other site
196162011044	active site
196162011045	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
196162011046	N- and C-terminal domain interface [polypeptide binding]; other site
196162011047	D-xylulose kinase; Region: XylB; TIGR01312
196162011048	putative active site [active]
196162011049	MgATP binding site [chemical binding]; other site
196162011050	catalytic site [active]
196162011051	metal binding site [ion binding]; metal-binding site
196162011052	putative xylulose binding site [chemical binding]; other site
196162011053	putative homodimer interface [polypeptide binding]; other site
196162011054	BtpA family; Region: BtpA; cl00440
196162011055	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
196162011056	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
196162011057	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
196162011058	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196162011059	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162011060	PemK-like protein; Region: PemK; cl00995
196162011061	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
196162011062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162011063	ATP binding site [chemical binding]; other site
196162011064	putative Mg++ binding site [ion binding]; other site
196162011065	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162011066	nucleotide binding region [chemical binding]; other site
196162011067	ATP-binding site [chemical binding]; other site
196162011068	Helicase associated domain (HA2); Region: HA2; pfam04408
196162011069	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
196162011070	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
196162011071	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
196162011072	Predicted oxidoreductase [General function prediction only]; Region: COG3573
196162011073	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196162011074	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162011075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162011076	active site
196162011077	phosphorylation site [posttranslational modification]
196162011078	intermolecular recognition site; other site
196162011079	dimerization interface [polypeptide binding]; other site
196162011080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162011081	DNA binding site [nucleotide binding]
196162011082	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162011083	dimer interface [polypeptide binding]; other site
196162011084	phosphorylation site [posttranslational modification]
196162011085	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162011086	ATP binding site [chemical binding]; other site
196162011087	Mg2+ binding site [ion binding]; other site
196162011088	G-X-G motif; other site
196162011089	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162011090	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162011091	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196162011092	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
196162011093	short chain dehydrogenase; Provisional; Region: PRK07832
196162011094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162011095	NAD(P) binding site [chemical binding]; other site
196162011096	active site
196162011097	Uncharacterized conserved protein [Function unknown]; Region: COG2966
196162011098	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
196162011099	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
196162011100	Protein of unknown function (DUF402); Region: DUF402; pfam04167
196162011101	carboxylate-amine ligase; Provisional; Region: PRK13517
196162011102	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
196162011103	DNA polymerase IV; Validated; Region: PRK03352
196162011104	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
196162011105	active site
196162011106	DNA binding site [nucleotide binding]
196162011107	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
196162011108	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162011109	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162011110	active site
196162011111	ATP binding site [chemical binding]; other site
196162011112	substrate binding site [chemical binding]; other site
196162011113	activation loop (A-loop); other site
196162011114	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
196162011115	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
196162011116	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
196162011117	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
196162011118	DNA methylase; Region: N6_N4_Mtase; pfam01555
196162011119	DNA methylase; Region: N6_N4_Mtase; cl17433
196162011120	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
196162011121	active site
196162011122	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
196162011123	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196162011124	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
196162011125	G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028
196162011126	active site
196162011127	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
196162011128	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162011129	NAD(P) binding site [chemical binding]; other site
196162011130	active site
196162011131	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162011132	active site
196162011133	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
196162011134	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
196162011135	metal binding site [ion binding]; metal-binding site
196162011136	putative dimer interface [polypeptide binding]; other site
196162011137	Predicted membrane protein [Function unknown]; Region: COG2860
196162011138	UPF0126 domain; Region: UPF0126; pfam03458
196162011139	UPF0126 domain; Region: UPF0126; pfam03458
196162011140	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
196162011141	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
196162011142	ligand binding site; other site
196162011143	oligomer interface; other site
196162011144	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
196162011145	N-terminal domain interface [polypeptide binding]; other site
196162011146	sulfate 1 binding site; other site
196162011147	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
196162011148	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
196162011149	Anaphase-promoting complex, cyclosome, subunit 4; Region: Apc4; pfam12896
196162011150	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
196162011151	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
196162011152	ATP-binding site [chemical binding]; other site
196162011153	Gluconate-6-phosphate binding site [chemical binding]; other site
196162011154	Shikimate kinase; Region: SKI; pfam01202
196162011155	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196162011156	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162011157	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
196162011158	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162011159	active site
196162011160	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
196162011161	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
196162011162	active site
196162011163	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
196162011164	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
196162011165	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
196162011166	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
196162011167	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
196162011168	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162011169	dimerization interface [polypeptide binding]; other site
196162011170	putative DNA binding site [nucleotide binding]; other site
196162011171	putative Zn2+ binding site [ion binding]; other site
196162011172	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196162011173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162011174	S-adenosylmethionine binding site [chemical binding]; other site
196162011175	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
196162011176	arsenical-resistance protein; Region: acr3; TIGR00832
196162011177	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
196162011178	Low molecular weight phosphatase family; Region: LMWPc; cl00105
196162011179	active site
196162011180	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
196162011181	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196162011182	metal-binding site [ion binding]
196162011183	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162011184	Soluble P-type ATPase [General function prediction only]; Region: COG4087
196162011185	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196162011186	metal-binding site [ion binding]
196162011187	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
196162011188	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162011189	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162011190	active site
196162011191	catalytic tetrad [active]
196162011192	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
196162011193	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
196162011194	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162011195	S-adenosylmethionine binding site [chemical binding]; other site
196162011196	Domain of unknown function DUF11; Region: DUF11; pfam01345
196162011197	Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172
196162011198	PLD-like domain; Region: PLDc_2; pfam13091
196162011199	putative active site [active]
196162011200	catalytic site [active]
196162011201	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162011202	PLD-like domain; Region: PLDc_2; pfam13091
196162011203	putative active site [active]
196162011204	catalytic site [active]
196162011205	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
196162011206	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
196162011207	substrate-cofactor binding pocket; other site
196162011208	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162011209	catalytic residue [active]
196162011210	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
196162011211	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
196162011212	NAD(P) binding site [chemical binding]; other site
196162011213	na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844
196162011214	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
196162011215	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162011216	PLD-like domain; Region: PLDc_2; pfam13091
196162011217	putative active site [active]
196162011218	catalytic site [active]
196162011219	PLD-like domain; Region: PLDc_2; pfam13091
196162011220	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162011221	putative active site [active]
196162011222	catalytic site [active]
196162011223	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
196162011224	GIY-YIG motif/motif A; other site
196162011225	putative active site [active]
196162011226	putative metal binding site [ion binding]; other site
196162011227	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
196162011228	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162011229	DNA binding residues [nucleotide binding]
196162011230	Fatty acid desaturase; Region: FA_desaturase; pfam00487
196162011231	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
196162011232	putative di-iron ligands [ion binding]; other site
196162011233	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162011234	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
196162011235	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162011236	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
196162011237	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
196162011238	tetramer interface [polypeptide binding]; other site
196162011239	TPP-binding site [chemical binding]; other site
196162011240	heterodimer interface [polypeptide binding]; other site
196162011241	phosphorylation loop region [posttranslational modification]
196162011242	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
196162011243	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
196162011244	alpha subunit interface [polypeptide binding]; other site
196162011245	TPP binding site [chemical binding]; other site
196162011246	heterodimer interface [polypeptide binding]; other site
196162011247	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196162011248	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196162011249	E3 interaction surface; other site
196162011250	lipoyl attachment site [posttranslational modification]; other site
196162011251	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
196162011252	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
196162011253	structural tetrad; other site
196162011254	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
196162011255	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162011256	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162011257	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162011258	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196162011259	Walker A/P-loop; other site
196162011260	ATP binding site [chemical binding]; other site
196162011261	Q-loop/lid; other site
196162011262	ABC transporter signature motif; other site
196162011263	Walker B; other site
196162011264	D-loop; other site
196162011265	H-loop/switch region; other site
196162011266	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
196162011267	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196162011268	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196162011269	FtsX-like permease family; Region: FtsX; pfam02687
196162011270	PrgI family protein; Region: PrgI; pfam12666
196162011271	Short C-terminal domain; Region: SHOCT; pfam09851
196162011272	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162011273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162011274	active site
196162011275	phosphorylation site [posttranslational modification]
196162011276	intermolecular recognition site; other site
196162011277	dimerization interface [polypeptide binding]; other site
196162011278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162011279	DNA binding site [nucleotide binding]
196162011280	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
196162011281	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
196162011282	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
196162011283	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
196162011284	catalytic residues [active]
196162011285	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
196162011286	putative homodimer interface [polypeptide binding]; other site
196162011287	putative homotetramer interface [polypeptide binding]; other site
196162011288	putative allosteric switch controlling residues; other site
196162011289	putative metal binding site [ion binding]; other site
196162011290	putative homodimer-homodimer interface [polypeptide binding]; other site
196162011291	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196162011292	metal-binding site [ion binding]
196162011293	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
196162011294	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
196162011295	metal-binding site [ion binding]
196162011296	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
196162011297	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
196162011298	amidase catalytic site [active]
196162011299	Zn binding residues [ion binding]; other site
196162011300	substrate binding site [chemical binding]; other site
196162011301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162011302	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
196162011303	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
196162011304	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196162011305	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
196162011306	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
196162011307	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196162011308	Active Sites [active]
196162011309	Protein of unknown function, DUF488; Region: DUF488; pfam04343
196162011310	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
196162011311	Cytokine receptor motif; other site
196162011312	SprT homologues; Region: SprT; cl01182
196162011313	SprT-like family; Region: SprT-like; pfam10263
196162011314	ERCC4 domain; Region: ERCC4; smart00891
196162011315	Lsr2; Region: Lsr2; pfam11774
196162011316	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
196162011317	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162011318	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162011319	catalytic residue [active]
196162011320	Nuclease-related domain; Region: NERD; pfam08378
196162011321	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203
196162011322	PLD-like domain; Region: PLDc_2; pfam13091
196162011323	putative homodimer interface [polypeptide binding]; other site
196162011324	putative active site [active]
196162011325	catalytic site [active]
196162011326	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196162011327	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
196162011328	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162011329	nucleotide binding region [chemical binding]; other site
196162011330	ATP-binding site [chemical binding]; other site
196162011331	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
196162011332	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
196162011333	active site
196162011334	catalytic site [active]
196162011335	substrate binding site [chemical binding]; other site
196162011336	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
196162011337	Dimer interface [polypeptide binding]; other site
196162011338	vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556
196162011339	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
196162011340	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
196162011341	active site
196162011342	dimer interface [polypeptide binding]; other site
196162011343	effector binding site; other site
196162011344	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
196162011345	TSCPD domain; Region: TSCPD; pfam12637
196162011346	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
196162011347	ATP cone domain; Region: ATP-cone; pfam03477
196162011348	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
196162011349	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162011350	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
196162011351	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162011352	DNA binding residues [nucleotide binding]
196162011353	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
196162011354	classical (c) SDRs; Region: SDR_c; cd05233
196162011355	NAD(P) binding site [chemical binding]; other site
196162011356	active site
196162011357	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
196162011358	LexA repressor; Validated; Region: PRK00215
196162011359	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
196162011360	Catalytic site [active]
196162011361	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162011362	active site
196162011363	PhoD-like phosphatase; Region: PhoD; pfam09423
196162011364	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
196162011365	putative active site [active]
196162011366	putative metal binding site [ion binding]; other site
196162011367	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
196162011368	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
196162011369	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
196162011370	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
196162011371	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
196162011372	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
196162011373	DEAD/DEAH box helicase; Region: DEAD; pfam00270
196162011374	ATP binding site [chemical binding]; other site
196162011375	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162011376	putative Mg++ binding site [ion binding]; other site
196162011377	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
196162011378	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162011379	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162011380	active site
196162011381	phosphorylation site [posttranslational modification]
196162011382	intermolecular recognition site; other site
196162011383	dimerization interface [polypeptide binding]; other site
196162011384	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162011385	DNA binding site [nucleotide binding]
196162011386	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162011387	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162011388	dimerization interface [polypeptide binding]; other site
196162011389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162011390	ATP binding site [chemical binding]; other site
196162011391	G-X-G motif; other site
196162011392	ApbE family; Region: ApbE; pfam02424
196162011393	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
196162011394	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
196162011395	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
196162011396	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
196162011397	active site
196162011398	catalytic triad [active]
196162011399	oxyanion hole [active]
196162011400	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162011401	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
196162011402	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
196162011403	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
196162011404	HflX GTPase family; Region: HflX; cd01878
196162011405	G1 box; other site
196162011406	GTP/Mg2+ binding site [chemical binding]; other site
196162011407	Switch I region; other site
196162011408	G2 box; other site
196162011409	G3 box; other site
196162011410	Switch II region; other site
196162011411	G4 box; other site
196162011412	G5 box; other site
196162011413	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162011414	hydroxyglutarate oxidase; Provisional; Region: PRK11728
196162011415	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
196162011416	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
196162011417	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
196162011418	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
196162011419	active site
196162011420	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162011421	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196162011422	NAD(P) binding site [chemical binding]; other site
196162011423	active site
196162011424	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
196162011425	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
196162011426	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
196162011427	RibD C-terminal domain; Region: RibD_C; cl17279
196162011428	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
196162011429	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
196162011430	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
196162011431	nudix motif; other site
196162011432	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
196162011433	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
196162011434	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162011435	FeS/SAM binding site; other site
196162011436	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
196162011437	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
196162011438	active site
196162011439	PHP-associated; Region: PHP_C; pfam13263
196162011440	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
196162011441	CoenzymeA binding site [chemical binding]; other site
196162011442	subunit interaction site [polypeptide binding]; other site
196162011443	PHB binding site; other site
196162011444	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
196162011445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162011446	S-adenosylmethionine binding site [chemical binding]; other site
196162011447	MarR family; Region: MarR_2; cl17246
196162011448	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
196162011449	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162011450	ABC transporter; Region: ABC_tran_2; pfam12848
196162011451	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
196162011452	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
196162011453	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
196162011454	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
196162011455	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
196162011456	Domain of unknown function (DUF348); Region: DUF348; pfam03990
196162011457	Domain of unknown function (DUF348); Region: DUF348; pfam03990
196162011458	Domain of unknown function (DUF348); Region: DUF348; pfam03990
196162011459	G5 domain; Region: G5; pfam07501
196162011460	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
196162011461	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
196162011462	active site
196162011463	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
196162011464	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
196162011465	Predicted methyltransferases [General function prediction only]; Region: COG0313
196162011466	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
196162011467	putative SAM binding site [chemical binding]; other site
196162011468	putative homodimer interface [polypeptide binding]; other site
196162011469	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
196162011470	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162011471	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162011472	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
196162011473	classical (c) SDRs; Region: SDR_c; cd05233
196162011474	NAD(P) binding site [chemical binding]; other site
196162011475	active site
196162011476	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
196162011477	classical (c) SDRs; Region: SDR_c; cd05233
196162011478	NAD(P) binding site [chemical binding]; other site
196162011479	active site
196162011480	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
196162011481	Phosphotransferase enzyme family; Region: APH; pfam01636
196162011482	putative active site [active]
196162011483	putative substrate binding site [chemical binding]; other site
196162011484	ATP binding site [chemical binding]; other site
196162011485	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162011486	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162011487	active site
196162011488	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
196162011489	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
196162011490	substrate binding pocket [chemical binding]; other site
196162011491	YCII-related domain; Region: YCII; cl00999
196162011492	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
196162011493	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162011494	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
196162011495	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162011496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162011497	S-adenosylmethionine binding site [chemical binding]; other site
196162011498	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
196162011499	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
196162011500	dimerization interface 3.5A [polypeptide binding]; other site
196162011501	active site
196162011502	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
196162011503	substrate binding site [chemical binding]; other site
196162011504	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196162011505	ATP binding site [chemical binding]; other site
196162011506	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162011507	DNA-binding site [nucleotide binding]; DNA binding site
196162011508	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
196162011509	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
196162011510	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
196162011511	alphaNTD homodimer interface [polypeptide binding]; other site
196162011512	alphaNTD - beta interaction site [polypeptide binding]; other site
196162011513	alphaNTD - beta' interaction site [polypeptide binding]; other site
196162011514	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
196162011515	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
196162011516	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
196162011517	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
196162011518	RNA binding surface [nucleotide binding]; other site
196162011519	30S ribosomal protein S11; Validated; Region: PRK05309
196162011520	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
196162011521	30S ribosomal protein S13; Region: bact_S13; TIGR03631
196162011522	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
196162011523	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
196162011524	rRNA binding site [nucleotide binding]; other site
196162011525	predicted 30S ribosome binding site; other site
196162011526	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
196162011527	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162011528	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
196162011529	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
196162011530	yybP-ykoY element as predicted by Rfam (RF00080), score 39.94
196162011531	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
196162011532	active site
196162011533	adenylate kinase; Reviewed; Region: adk; PRK00279
196162011534	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
196162011535	AMP-binding site [chemical binding]; other site
196162011536	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
196162011537	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
196162011538	SecY translocase; Region: SecY; pfam00344
196162011539	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
196162011540	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
196162011541	23S rRNA binding site [nucleotide binding]; other site
196162011542	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
196162011543	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
196162011544	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
196162011545	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
196162011546	5S rRNA interface [nucleotide binding]; other site
196162011547	L5 interface [polypeptide binding]; other site
196162011548	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
196162011549	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
196162011550	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
196162011551	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
196162011552	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
196162011553	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
196162011554	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
196162011555	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
196162011556	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
196162011557	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
196162011558	RNA binding site [nucleotide binding]; other site
196162011559	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
196162011560	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
196162011561	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
196162011562	putative translocon interaction site; other site
196162011563	23S rRNA interface [nucleotide binding]; other site
196162011564	signal recognition particle (SRP54) interaction site; other site
196162011565	L23 interface [polypeptide binding]; other site
196162011566	trigger factor interaction site; other site
196162011567	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
196162011568	23S rRNA interface [nucleotide binding]; other site
196162011569	5S rRNA interface [nucleotide binding]; other site
196162011570	putative antibiotic binding site [chemical binding]; other site
196162011571	L25 interface [polypeptide binding]; other site
196162011572	L27 interface [polypeptide binding]; other site
196162011573	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
196162011574	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
196162011575	G-X-X-G motif; other site
196162011576	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
196162011577	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
196162011578	putative translocon binding site; other site
196162011579	protein-rRNA interface [nucleotide binding]; other site
196162011580	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
196162011581	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
196162011582	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
196162011583	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
196162011584	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
196162011585	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
196162011586	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
196162011587	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
196162011588	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
196162011589	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
196162011590	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
196162011591	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162011592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162011593	Walker A motif; other site
196162011594	ATP binding site [chemical binding]; other site
196162011595	Walker B motif; other site
196162011596	arginine finger; other site
196162011597	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
196162011598	Protein of unknown function DUF58; Region: DUF58; pfam01882
196162011599	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
196162011600	RDD family; Region: RDD; pfam06271
196162011601	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
196162011602	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
196162011603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162011604	dimer interface [polypeptide binding]; other site
196162011605	conserved gate region; other site
196162011606	putative PBP binding loops; other site
196162011607	ABC-ATPase subunit interface; other site
196162011608	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162011609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162011610	dimer interface [polypeptide binding]; other site
196162011611	conserved gate region; other site
196162011612	putative PBP binding loops; other site
196162011613	ABC-ATPase subunit interface; other site
196162011614	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
196162011615	beta-galactosidase; Region: BGL; TIGR03356
196162011616	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162011617	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162011618	DNA binding site [nucleotide binding]
196162011619	domain linker motif; other site
196162011620	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196162011621	dimerization interface [polypeptide binding]; other site
196162011622	ligand binding site [chemical binding]; other site
196162011623	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
196162011624	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
196162011625	aminotransferase; Validated; Region: PRK07046
196162011626	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162011627	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162011628	catalytic residue [active]
196162011629	elongation factor Tu; Reviewed; Region: PRK00049
196162011630	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
196162011631	G1 box; other site
196162011632	GEF interaction site [polypeptide binding]; other site
196162011633	GTP/Mg2+ binding site [chemical binding]; other site
196162011634	Switch I region; other site
196162011635	G2 box; other site
196162011636	G3 box; other site
196162011637	Switch II region; other site
196162011638	G4 box; other site
196162011639	G5 box; other site
196162011640	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
196162011641	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
196162011642	Antibiotic Binding Site [chemical binding]; other site
196162011643	elongation factor G; Reviewed; Region: PRK00007
196162011644	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
196162011645	G1 box; other site
196162011646	putative GEF interaction site [polypeptide binding]; other site
196162011647	GTP/Mg2+ binding site [chemical binding]; other site
196162011648	Switch I region; other site
196162011649	G2 box; other site
196162011650	G3 box; other site
196162011651	Switch II region; other site
196162011652	G4 box; other site
196162011653	G5 box; other site
196162011654	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
196162011655	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
196162011656	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
196162011657	30S ribosomal protein S7; Validated; Region: PRK05302
196162011658	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
196162011659	S17 interaction site [polypeptide binding]; other site
196162011660	S8 interaction site; other site
196162011661	16S rRNA interaction site [nucleotide binding]; other site
196162011662	streptomycin interaction site [chemical binding]; other site
196162011663	23S rRNA interaction site [nucleotide binding]; other site
196162011664	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
196162011665	H+ Antiporter protein; Region: 2A0121; TIGR00900
196162011666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162011667	putative substrate translocation pore; other site
196162011668	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162011669	MarR family; Region: MarR; pfam01047
196162011670	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
196162011671	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
196162011672	H+ Antiporter protein; Region: 2A0121; TIGR00900
196162011673	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
196162011674	DNA-binding site [nucleotide binding]; DNA binding site
196162011675	RNA-binding motif; other site
196162011676	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
196162011677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
196162011678	motif II; other site
196162011679	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
196162011680	Ligand Binding Site [chemical binding]; other site
196162011681	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
196162011682	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162011683	PLD-like domain; Region: PLDc_2; pfam13091
196162011684	putative active site [active]
196162011685	catalytic site [active]
196162011686	PLD-like domain; Region: PLDc_2; pfam13091
196162011687	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
196162011688	putative active site [active]
196162011689	catalytic site [active]
196162011690	AMP-binding domain protein; Validated; Region: PRK08315
196162011691	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162011692	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
196162011693	acyl-activating enzyme (AAE) consensus motif; other site
196162011694	acyl-activating enzyme (AAE) consensus motif; other site
196162011695	putative AMP binding site [chemical binding]; other site
196162011696	putative active site [active]
196162011697	putative CoA binding site [chemical binding]; other site
196162011698	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162011699	hydrophobic ligand binding site; other site
196162011700	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
196162011701	RDD family; Region: RDD; pfam06271
196162011702	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
196162011703	phosphopeptide binding site; other site
196162011704	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
196162011705	phosphopeptide binding site; other site
196162011706	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
196162011707	active site
196162011708	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
196162011709	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
196162011710	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162011711	catalytic residue [active]
196162011712	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
196162011713	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162011714	putative DNA binding site [nucleotide binding]; other site
196162011715	putative Zn2+ binding site [ion binding]; other site
196162011716	AsnC family; Region: AsnC_trans_reg; pfam01037
196162011717	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
196162011718	WYL domain; Region: WYL; pfam13280
196162011719	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
196162011720	CGNR zinc finger; Region: zf-CGNR; pfam11706
196162011721	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
196162011722	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
196162011723	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
196162011724	ATP binding site [chemical binding]; other site
196162011725	putative Mg++ binding site [ion binding]; other site
196162011726	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162011727	nucleotide binding region [chemical binding]; other site
196162011728	ATP-binding site [chemical binding]; other site
196162011729	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
196162011730	Peptidase family M23; Region: Peptidase_M23; pfam01551
196162011731	tryptophan synthase subunit beta; Reviewed; Region: PRK12391
196162011732	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
196162011733	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162011734	catalytic residue [active]
196162011735	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196162011736	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162011737	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
196162011738	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
196162011739	ligand binding site [chemical binding]; other site
196162011740	NAD binding site [chemical binding]; other site
196162011741	tetramer interface [polypeptide binding]; other site
196162011742	catalytic site [active]
196162011743	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
196162011744	L-serine binding site [chemical binding]; other site
196162011745	ACT domain interface; other site
196162011746	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
196162011747	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
196162011748	Transthyretin-like family; Region: DUF290; pfam01060
196162011749	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
196162011750	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
196162011751	Protein of unknown function (DUF4031); Region: DUF4031; pfam13223
196162011752	CutC family; Region: CutC; cl01218
196162011753	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
196162011754	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162011755	DNA-binding site [nucleotide binding]; DNA binding site
196162011756	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
196162011757	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
196162011758	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196162011759	FtsX-like permease family; Region: FtsX; pfam02687
196162011760	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
196162011761	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
196162011762	FtsX-like permease family; Region: FtsX; pfam02687
196162011763	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
196162011764	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
196162011765	Walker A/P-loop; other site
196162011766	ATP binding site [chemical binding]; other site
196162011767	Q-loop/lid; other site
196162011768	ABC transporter signature motif; other site
196162011769	Walker B; other site
196162011770	D-loop; other site
196162011771	H-loop/switch region; other site
196162011772	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
196162011773	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
196162011774	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162011775	S-adenosylmethionine binding site [chemical binding]; other site
196162011776	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
196162011777	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162011778	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162011779	putative substrate translocation pore; other site
196162011780	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823
196162011781	putative hydrophobic ligand binding site [chemical binding]; other site
196162011782	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162011783	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
196162011784	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162011785	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162011786	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162011787	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162011788	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162011789	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
196162011790	DNA binding site [nucleotide binding]
196162011791	PKD domain; Region: PKD; pfam00801
196162011792	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
196162011793	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
196162011794	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
196162011795	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
196162011796	XdhC Rossmann domain; Region: XdhC_C; pfam13478
196162011797	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
196162011798	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
196162011799	metal ion-dependent adhesion site (MIDAS); other site
196162011800	MoxR-like ATPases [General function prediction only]; Region: COG0714
196162011801	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162011802	Walker A motif; other site
196162011803	ATP binding site [chemical binding]; other site
196162011804	Walker B motif; other site
196162011805	arginine finger; other site
196162011806	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
196162011807	Ligand binding site; other site
196162011808	metal-binding site
196162011809	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162011810	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162011811	DNA binding residues [nucleotide binding]
196162011812	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
196162011813	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
196162011814	gating phenylalanine in ion channel; other site
196162011815	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
196162011816	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
196162011817	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162011818	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
196162011819	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
196162011820	ring oligomerisation interface [polypeptide binding]; other site
196162011821	ATP/Mg binding site [chemical binding]; other site
196162011822	stacking interactions; other site
196162011823	hinge regions; other site
196162011824	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162011825	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162011826	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162011827	DNA binding site [nucleotide binding]
196162011828	domain linker motif; other site
196162011829	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
196162011830	putative dimerization interface [polypeptide binding]; other site
196162011831	putative ligand binding site [chemical binding]; other site
196162011832	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
196162011833	active site
196162011834	catalytic triad [active]
196162011835	oxyanion hole [active]
196162011836	ThiS family; Region: ThiS; pfam02597
196162011837	charged pocket; other site
196162011838	hydrophobic patch; other site
196162011839	threonine synthase; Validated; Region: PRK07591
196162011840	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
196162011841	homodimer interface [polypeptide binding]; other site
196162011842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162011843	catalytic residue [active]
196162011844	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
196162011845	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162011846	Walker A motif; other site
196162011847	ATP binding site [chemical binding]; other site
196162011848	Walker B motif; other site
196162011849	arginine finger; other site
196162011850	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
196162011851	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
196162011852	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
196162011853	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
196162011854	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
196162011855	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196162011856	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196162011857	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196162011858	Putative sensor; Region: Sensor; pfam13796
196162011859	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
196162011860	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
196162011861	active site
196162011862	homotetramer interface [polypeptide binding]; other site
196162011863	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
196162011864	MFS/sugar transport protein; Region: MFS_2; pfam13347
196162011865	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
196162011866	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
196162011867	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
196162011868	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
196162011869	catalytic residue [active]
196162011870	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
196162011871	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
196162011872	substrate binding site [chemical binding]; other site
196162011873	ATP binding site [chemical binding]; other site
196162011874	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162011875	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162011876	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
196162011877	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162011878	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
196162011879	ligand binding site [chemical binding]; other site
196162011880	active site
196162011881	UGI interface [polypeptide binding]; other site
196162011882	catalytic site [active]
196162011883	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
196162011884	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
196162011885	putative active site [active]
196162011886	metal binding site [ion binding]; metal-binding site
196162011887	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
196162011888	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
196162011889	NAD(P) binding site [chemical binding]; other site
196162011890	catalytic residues [active]
196162011891	choline dehydrogenase; Validated; Region: PRK02106
196162011892	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
196162011893	pyridoxamine kinase; Validated; Region: PRK05756
196162011894	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
196162011895	pyridoxal binding site [chemical binding]; other site
196162011896	dimer interface [polypeptide binding]; other site
196162011897	ATP binding site [chemical binding]; other site
196162011898	Domain of unknown function (DUF305); Region: DUF305; pfam03713
196162011899	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
196162011900	classical (c) SDRs; Region: SDR_c; cd05233
196162011901	NAD(P) binding site [chemical binding]; other site
196162011902	active site
196162011903	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
196162011904	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
196162011905	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
196162011906	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
196162011907	Transposase; Region: DDE_Tnp_ISL3; pfam01610
196162011908	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162011909	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162011910	Walker A/P-loop; other site
196162011911	ATP binding site [chemical binding]; other site
196162011912	Q-loop/lid; other site
196162011913	ABC transporter signature motif; other site
196162011914	Walker B; other site
196162011915	D-loop; other site
196162011916	H-loop/switch region; other site
196162011917	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162011918	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162011919	Walker A/P-loop; other site
196162011920	ATP binding site [chemical binding]; other site
196162011921	Q-loop/lid; other site
196162011922	ABC transporter signature motif; other site
196162011923	Walker B; other site
196162011924	D-loop; other site
196162011925	H-loop/switch region; other site
196162011926	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162011927	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162011928	TM-ABC transporter signature motif; other site
196162011929	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162011930	TM-ABC transporter signature motif; other site
196162011931	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162011932	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162011933	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
196162011934	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
196162011935	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
196162011936	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
196162011937	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
196162011938	active site
196162011939	HIGH motif; other site
196162011940	nucleotide binding site [chemical binding]; other site
196162011941	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
196162011942	KMSKS motif; other site
196162011943	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
196162011944	tRNA binding surface [nucleotide binding]; other site
196162011945	anticodon binding site; other site
196162011946	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
196162011947	putative active site [active]
196162011948	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
196162011949	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
196162011950	Moco binding site; other site
196162011951	metal coordination site [ion binding]; other site
196162011952	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084
196162011953	homotrimer interaction site [polypeptide binding]; other site
196162011954	zinc binding site [ion binding]; other site
196162011955	CDP-binding sites; other site
196162011956	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
196162011957	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
196162011958	putative hexamer interface [polypeptide binding]; other site
196162011959	putative hexagonal pore; other site
196162011960	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
196162011961	putative hexamer interface [polypeptide binding]; other site
196162011962	putative hexagonal pore; other site
196162011963	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
196162011964	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162011965	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
196162011966	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
196162011967	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
196162011968	Hexamer interface [polypeptide binding]; other site
196162011969	Putative hexagonal pore residue; other site
196162011970	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
196162011971	putative catalytic cysteine [active]
196162011972	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
196162011973	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
196162011974	putative hexamer interface [polypeptide binding]; other site
196162011975	putative hexagonal pore; other site
196162011976	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
196162011977	putative hexamer interface [polypeptide binding]; other site
196162011978	putative hexagonal pore; other site
196162011979	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985
196162011980	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
196162011981	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
196162011982	Ethanolamine utilisation protein EutA; Region: EutA; pfam06277
196162011983	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
196162011984	Hexamer/Pentamer interface [polypeptide binding]; other site
196162011985	central pore; other site
196162011986	ethanolamine permease; Region: 2A0305; TIGR00908
196162011987	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
196162011988	substrate binding site; other site
196162011989	dimer interface; other site
196162011990	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
196162011991	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
196162011992	catalytic core [active]
196162011993	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
196162011994	PhoU domain; Region: PhoU; pfam01895
196162011995	PhoU domain; Region: PhoU; pfam01895
196162011996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162011997	dimer interface [polypeptide binding]; other site
196162011998	phosphorylation site [posttranslational modification]
196162011999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162012000	ATP binding site [chemical binding]; other site
196162012001	G-X-G motif; other site
196162012002	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162012003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162012004	active site
196162012005	phosphorylation site [posttranslational modification]
196162012006	intermolecular recognition site; other site
196162012007	dimerization interface [polypeptide binding]; other site
196162012008	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162012009	DNA binding site [nucleotide binding]
196162012010	EamA-like transporter family; Region: EamA; pfam00892
196162012011	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
196162012012	EamA-like transporter family; Region: EamA; pfam00892
196162012013	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
196162012014	ABC1 family; Region: ABC1; cl17513
196162012015	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
196162012016	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
196162012017	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
196162012018	putative ADP-binding pocket [chemical binding]; other site
196162012019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162012020	malonic semialdehyde reductase; Provisional; Region: PRK10538
196162012021	NAD(P) binding site [chemical binding]; other site
196162012022	active site
196162012023	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
196162012024	aspartate racemase; Region: asp_race; TIGR00035
196162012025	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
196162012026	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
196162012027	active site
196162012028	Zn binding site [ion binding]; other site
196162012029	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
196162012030	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
196162012031	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
196162012032	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
196162012033	G1 box; other site
196162012034	putative GEF interaction site [polypeptide binding]; other site
196162012035	GTP/Mg2+ binding site [chemical binding]; other site
196162012036	Switch I region; other site
196162012037	G2 box; other site
196162012038	G3 box; other site
196162012039	Switch II region; other site
196162012040	G4 box; other site
196162012041	G5 box; other site
196162012042	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
196162012043	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
196162012044	Predicted oxidoreductase [General function prediction only]; Region: COG3573
196162012045	hypothetical protein; Validated; Region: PRK07121
196162012046	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012047	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012048	active site
196162012049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162012050	DNA-binding site [nucleotide binding]; DNA binding site
196162012051	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162012052	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
196162012053	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
196162012054	putative active site [active]
196162012055	putative catalytic site [active]
196162012056	probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841
196162012057	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162012058	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
196162012059	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162012060	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162012061	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
196162012062	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
196162012063	homotrimer interaction site [polypeptide binding]; other site
196162012064	putative active site [active]
196162012065	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
196162012066	homotrimer interaction site [polypeptide binding]; other site
196162012067	putative active site [active]
196162012068	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
196162012069	putative active site [active]
196162012070	homotrimer interaction site [polypeptide binding]; other site
196162012071	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
196162012072	active site
196162012073	catalytic site [active]
196162012074	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
196162012075	active site 2 [active]
196162012076	active site 1 [active]
196162012077	thiolase; Provisional; Region: PRK06158
196162012078	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162012079	active site
196162012080	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
196162012081	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162012082	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012083	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012084	active site
196162012085	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
196162012086	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162012087	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162012088	hypothetical protein; Validated; Region: PRK07121
196162012089	L-aspartate oxidase; Provisional; Region: PRK06175
196162012090	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
196162012091	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
196162012092	Predicted oxidoreductase [General function prediction only]; Region: COG3573
196162012093	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
196162012094	active site
196162012095	metal binding site [ion binding]; metal-binding site
196162012096	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
196162012097	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012098	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162012099	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
196162012100	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
196162012101	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162012102	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162012103	Putative cyclase; Region: Cyclase; pfam04199
196162012104	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
196162012105	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
196162012106	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162012107	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162012108	active site
196162012109	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162012110	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162012111	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
196162012112	active site
196162012113	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
196162012114	active site
196162012115	short chain dehydrogenase; Provisional; Region: PRK08219
196162012116	classical (c) SDRs; Region: SDR_c; cd05233
196162012117	NAD(P) binding site [chemical binding]; other site
196162012118	active site
196162012119	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
196162012120	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196162012121	Walker A/P-loop; other site
196162012122	ATP binding site [chemical binding]; other site
196162012123	Q-loop/lid; other site
196162012124	ABC transporter signature motif; other site
196162012125	Walker B; other site
196162012126	D-loop; other site
196162012127	H-loop/switch region; other site
196162012128	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
196162012129	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
196162012130	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
196162012131	Walker A/P-loop; other site
196162012132	ATP binding site [chemical binding]; other site
196162012133	Q-loop/lid; other site
196162012134	ABC transporter signature motif; other site
196162012135	Walker B; other site
196162012136	D-loop; other site
196162012137	H-loop/switch region; other site
196162012138	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
196162012139	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
196162012140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162012141	dimer interface [polypeptide binding]; other site
196162012142	conserved gate region; other site
196162012143	putative PBP binding loops; other site
196162012144	ABC-ATPase subunit interface; other site
196162012145	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
196162012146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162012147	dimer interface [polypeptide binding]; other site
196162012148	conserved gate region; other site
196162012149	putative PBP binding loops; other site
196162012150	ABC-ATPase subunit interface; other site
196162012151	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
196162012152	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162012153	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162012154	putative DNA binding site [nucleotide binding]; other site
196162012155	putative Zn2+ binding site [ion binding]; other site
196162012156	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162012157	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
196162012158	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162012159	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
196162012160	acyl-activating enzyme (AAE) consensus motif; other site
196162012161	acyl-activating enzyme (AAE) consensus motif; other site
196162012162	putative AMP binding site [chemical binding]; other site
196162012163	putative active site [active]
196162012164	putative CoA binding site [chemical binding]; other site
196162012165	Prostaglandin dehydrogenases; Region: PGDH; cd05288
196162012166	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
196162012167	NAD(P) binding site [chemical binding]; other site
196162012168	substrate binding site [chemical binding]; other site
196162012169	dimer interface [polypeptide binding]; other site
196162012170	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
196162012171	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162012172	active site
196162012173	SnoaL-like domain; Region: SnoaL_3; pfam13474
196162012174	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
196162012175	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162012176	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162012177	Walker A/P-loop; other site
196162012178	ATP binding site [chemical binding]; other site
196162012179	Q-loop/lid; other site
196162012180	ABC transporter signature motif; other site
196162012181	Walker B; other site
196162012182	D-loop; other site
196162012183	H-loop/switch region; other site
196162012184	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162012185	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162012186	TM-ABC transporter signature motif; other site
196162012187	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162012188	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162012189	Walker A/P-loop; other site
196162012190	ATP binding site [chemical binding]; other site
196162012191	Q-loop/lid; other site
196162012192	ABC transporter signature motif; other site
196162012193	Walker B; other site
196162012194	D-loop; other site
196162012195	H-loop/switch region; other site
196162012196	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162012197	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162012198	TM-ABC transporter signature motif; other site
196162012199	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162012200	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
196162012201	ligand binding site [chemical binding]; other site
196162012202	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162012203	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162012204	N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045
196162012205	active site
196162012206	enoyl-CoA hydratase; Provisional; Region: PRK06688
196162012207	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162012208	substrate binding site [chemical binding]; other site
196162012209	oxyanion hole (OAH) forming residues; other site
196162012210	trimer interface [polypeptide binding]; other site
196162012211	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162012212	carboxyltransferase (CT) interaction site; other site
196162012213	biotinylation site [posttranslational modification]; other site
196162012214	MoaC_like    Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446
196162012215	homodimer interaction site [polypeptide binding]; other site
196162012216	putative active site [active]
196162012217	putative catalytic site [active]
196162012218	enoyl-CoA hydratase; Provisional; Region: PRK06688
196162012219	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162012220	substrate binding site [chemical binding]; other site
196162012221	oxyanion hole (OAH) forming residues; other site
196162012222	trimer interface [polypeptide binding]; other site
196162012223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162012224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162012225	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
196162012226	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162012227	Walker A/P-loop; other site
196162012228	ATP binding site [chemical binding]; other site
196162012229	Q-loop/lid; other site
196162012230	ABC transporter signature motif; other site
196162012231	Walker B; other site
196162012232	D-loop; other site
196162012233	H-loop/switch region; other site
196162012234	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162012235	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162012236	Walker A/P-loop; other site
196162012237	ATP binding site [chemical binding]; other site
196162012238	Q-loop/lid; other site
196162012239	ABC transporter signature motif; other site
196162012240	Walker B; other site
196162012241	D-loop; other site
196162012242	H-loop/switch region; other site
196162012243	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162012244	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162012245	TM-ABC transporter signature motif; other site
196162012246	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162012247	TM-ABC transporter signature motif; other site
196162012248	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
196162012249	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162012250	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162012251	acyl-activating enzyme (AAE) consensus motif; other site
196162012252	acyl-activating enzyme (AAE) consensus motif; other site
196162012253	AMP binding site [chemical binding]; other site
196162012254	active site
196162012255	CoA binding site [chemical binding]; other site
196162012256	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
196162012257	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162012258	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
196162012259	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
196162012260	dimer interface [polypeptide binding]; other site
196162012261	active site
196162012262	short chain dehydrogenase; Provisional; Region: PRK07791
196162012263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162012264	NAD(P) binding site [chemical binding]; other site
196162012265	active site
196162012266	crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155
196162012267	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162012268	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934
196162012269	putative active site [active]
196162012270	putative CoA binding site [chemical binding]; other site
196162012271	putative AMP binding site [chemical binding]; other site
196162012272	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162012273	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162012274	TM-ABC transporter signature motif; other site
196162012275	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162012276	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162012277	TM-ABC transporter signature motif; other site
196162012278	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162012279	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162012280	Walker A/P-loop; other site
196162012281	ATP binding site [chemical binding]; other site
196162012282	Q-loop/lid; other site
196162012283	ABC transporter signature motif; other site
196162012284	Walker B; other site
196162012285	D-loop; other site
196162012286	H-loop/switch region; other site
196162012287	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
196162012288	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162012289	Walker A/P-loop; other site
196162012290	ATP binding site [chemical binding]; other site
196162012291	Q-loop/lid; other site
196162012292	ABC transporter signature motif; other site
196162012293	Walker B; other site
196162012294	D-loop; other site
196162012295	H-loop/switch region; other site
196162012296	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162012297	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162012298	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162012299	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
196162012300	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
196162012301	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012302	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012303	active site
196162012304	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
196162012305	Phosphotransferase enzyme family; Region: APH; pfam01636
196162012306	putative active site [active]
196162012307	putative substrate binding site [chemical binding]; other site
196162012308	ATP binding site [chemical binding]; other site
196162012309	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012310	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012311	active site
196162012312	acetyl-CoA acetyltransferase; Provisional; Region: PRK06064
196162012313	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
196162012314	active site
196162012315	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
196162012316	DUF35 OB-fold domain; Region: DUF35; pfam01796
196162012317	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196162012318	classical (c) SDRs; Region: SDR_c; cd05233
196162012319	NAD(P) binding site [chemical binding]; other site
196162012320	active site
196162012321	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012322	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012323	active site
196162012324	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
196162012325	putative active site [active]
196162012326	putative catalytic site [active]
196162012327	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
196162012328	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196162012329	AMP-binding domain protein; Validated; Region: PRK08315
196162012330	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162012331	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
196162012332	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
196162012333	acyl-activating enzyme (AAE) consensus motif; other site
196162012334	acyl-activating enzyme (AAE) consensus motif; other site
196162012335	putative AMP binding site [chemical binding]; other site
196162012336	putative active site [active]
196162012337	putative CoA binding site [chemical binding]; other site
196162012338	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
196162012339	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
196162012340	FMN binding site [chemical binding]; other site
196162012341	substrate binding site [chemical binding]; other site
196162012342	putative catalytic residue [active]
196162012343	enoyl-CoA hydratase; Provisional; Region: PRK06190
196162012344	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162012345	substrate binding site [chemical binding]; other site
196162012346	oxyanion hole (OAH) forming residues; other site
196162012347	trimer interface [polypeptide binding]; other site
196162012348	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
196162012349	active site
196162012350	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
196162012351	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162012352	substrate binding site [chemical binding]; other site
196162012353	oxyanion hole (OAH) forming residues; other site
196162012354	trimer interface [polypeptide binding]; other site
196162012355	putative acyltransferase; Provisional; Region: PRK05790
196162012356	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162012357	dimer interface [polypeptide binding]; other site
196162012358	active site
196162012359	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
196162012360	B12 binding site [chemical binding]; other site
196162012361	cobalt ligand [ion binding]; other site
196162012362	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
196162012363	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162012364	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
196162012365	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
196162012366	nucleoside/Zn binding site; other site
196162012367	dimer interface [polypeptide binding]; other site
196162012368	catalytic motif [active]
196162012369	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162012370	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162012371	TM-ABC transporter signature motif; other site
196162012372	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
196162012373	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162012374	TM-ABC transporter signature motif; other site
196162012375	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
196162012376	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162012377	Walker A/P-loop; other site
196162012378	ATP binding site [chemical binding]; other site
196162012379	Q-loop/lid; other site
196162012380	ABC transporter signature motif; other site
196162012381	Walker B; other site
196162012382	D-loop; other site
196162012383	H-loop/switch region; other site
196162012384	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162012385	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
196162012386	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
196162012387	putative ligand binding site [chemical binding]; other site
196162012388	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
196162012389	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162012390	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
196162012391	active site
196162012392	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
196162012393	Metallo-peptidase family M12B Reprolysin-like; Region: Reprolysin_2; pfam13574
196162012394	Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342
196162012395	hypothetical protein; Provisional; Region: PRK14059
196162012396	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
196162012397	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
196162012398	dihydropteroate synthase; Region: DHPS; TIGR01496
196162012399	substrate binding pocket [chemical binding]; other site
196162012400	dimer interface [polypeptide binding]; other site
196162012401	inhibitor binding site; inhibition site
196162012402	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
196162012403	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
196162012404	Ligand binding site; other site
196162012405	Putative Catalytic site; other site
196162012406	DXD motif; other site
196162012407	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162012408	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162012409	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
196162012410	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
196162012411	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
196162012412	active site
196162012413	metal binding site [ion binding]; metal-binding site
196162012414	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
196162012415	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162012416	NAD(P) binding site [chemical binding]; other site
196162012417	active site
196162012418	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
196162012419	active site
196162012420	metal-binding site [ion binding]
196162012421	nucleotide-binding site [chemical binding]; other site
196162012422	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
196162012423	Sulfate transporter family; Region: Sulfate_transp; pfam00916
196162012424	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
196162012425	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162012426	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162012427	putative DNA binding site [nucleotide binding]; other site
196162012428	putative Zn2+ binding site [ion binding]; other site
196162012429	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
196162012430	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
196162012431	[4Fe-4S] binding site [ion binding]; other site
196162012432	molybdopterin cofactor binding site; other site
196162012433	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
196162012434	molybdopterin cofactor binding site; other site
196162012435	short chain dehydrogenase; Provisional; Region: PRK07109
196162012436	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
196162012437	putative NAD(P) binding site [chemical binding]; other site
196162012438	active site
196162012439	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162012440	FAD binding domain; Region: FAD_binding_4; pfam01565
196162012441	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
196162012442	thiamine pyrophosphate protein; Provisional; Region: PRK08273
196162012443	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
196162012444	PYR/PP interface [polypeptide binding]; other site
196162012445	dimer interface [polypeptide binding]; other site
196162012446	tetramer interface [polypeptide binding]; other site
196162012447	TPP binding site [chemical binding]; other site
196162012448	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
196162012449	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
196162012450	TPP-binding site [chemical binding]; other site
196162012451	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328
196162012452	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
196162012453	putative active site pocket [active]
196162012454	putative metal binding site [ion binding]; other site
196162012455	Glucose dehydrogenase; Region: glucose_DH; cd08230
196162012456	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
196162012457	NADP binding site [chemical binding]; other site
196162012458	catalytic Zn binding site [ion binding]; other site
196162012459	structural Zn binding site [ion binding]; other site
196162012460	dimer interface [polypeptide binding]; other site
196162012461	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
196162012462	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196162012463	AAA domain; Region: AAA_14; pfam13173
196162012464	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
196162012465	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
196162012466	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
196162012467	NADP-binding site; other site
196162012468	homotetramer interface [polypeptide binding]; other site
196162012469	substrate binding site [chemical binding]; other site
196162012470	homodimer interface [polypeptide binding]; other site
196162012471	active site
196162012472	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
196162012473	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
196162012474	NADP-binding site; other site
196162012475	homotetramer interface [polypeptide binding]; other site
196162012476	substrate binding site [chemical binding]; other site
196162012477	homodimer interface [polypeptide binding]; other site
196162012478	active site
196162012479	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
196162012480	active site
196162012481	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
196162012482	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
196162012483	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
196162012484	NAD(P) binding site [chemical binding]; other site
196162012485	homodimer interface [polypeptide binding]; other site
196162012486	substrate binding site [chemical binding]; other site
196162012487	active site
196162012488	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
196162012489	Chain length determinant protein; Region: Wzz; pfam02706
196162012490	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
196162012491	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162012492	Magnesium ion binding site [ion binding]; other site
196162012493	Cupin domain; Region: Cupin_2; cl17218
196162012494	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
196162012495	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
196162012496	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
196162012497	NAD(P) binding site [chemical binding]; other site
196162012498	catalytic residues [active]
196162012499	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
196162012500	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
196162012501	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162012502	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162012503	active site
196162012504	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
196162012505	active site
196162012506	catalytic motif [active]
196162012507	Zn binding site [ion binding]; other site
196162012508	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162012509	TM-ABC transporter signature motif; other site
196162012510	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162012511	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
196162012512	TM-ABC transporter signature motif; other site
196162012513	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
196162012514	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
196162012515	Walker A/P-loop; other site
196162012516	ATP binding site [chemical binding]; other site
196162012517	Q-loop/lid; other site
196162012518	ABC transporter signature motif; other site
196162012519	Walker B; other site
196162012520	D-loop; other site
196162012521	H-loop/switch region; other site
196162012522	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
196162012523	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
196162012524	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
196162012525	ligand binding site [chemical binding]; other site
196162012526	C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299
196162012527	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
196162012528	ligand binding site [chemical binding]; other site
196162012529	NAD binding site [chemical binding]; other site
196162012530	catalytic site [active]
196162012531	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162012532	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162012533	DNA-binding site [nucleotide binding]; DNA binding site
196162012534	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
196162012535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162012536	NAD(P) binding site [chemical binding]; other site
196162012537	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
196162012538	active site
196162012539	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
196162012540	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
196162012541	dimer interface [polypeptide binding]; other site
196162012542	NADP binding site [chemical binding]; other site
196162012543	catalytic residues [active]
196162012544	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
196162012545	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
196162012546	non-specific DNA binding site [nucleotide binding]; other site
196162012547	salt bridge; other site
196162012548	sequence-specific DNA binding site [nucleotide binding]; other site
196162012549	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
196162012550	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
196162012551	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
196162012552	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
196162012553	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
196162012554	NADP-binding site; other site
196162012555	homotetramer interface [polypeptide binding]; other site
196162012556	substrate binding site [chemical binding]; other site
196162012557	homodimer interface [polypeptide binding]; other site
196162012558	active site
196162012559	L-asparaginase II; Region: Asparaginase_II; pfam06089
196162012560	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
196162012561	AAA domain; Region: AAA_33; pfam13671
196162012562	ligand-binding site [chemical binding]; other site
196162012563	Low molecular weight phosphatase family; Region: LMWPc; cl00105
196162012564	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
196162012565	active site
196162012566	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196162012567	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
196162012568	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
196162012569	Active Sites [active]
196162012570	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
196162012571	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
196162012572	CysD dimerization site [polypeptide binding]; other site
196162012573	G1 box; other site
196162012574	putative GEF interaction site [polypeptide binding]; other site
196162012575	GTP/Mg2+ binding site [chemical binding]; other site
196162012576	Switch I region; other site
196162012577	G2 box; other site
196162012578	G3 box; other site
196162012579	Switch II region; other site
196162012580	G4 box; other site
196162012581	G5 box; other site
196162012582	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
196162012583	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
196162012584	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
196162012585	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
196162012586	putative trimer interface [polypeptide binding]; other site
196162012587	putative active site [active]
196162012588	putative substrate binding site [chemical binding]; other site
196162012589	putative CoA binding site [chemical binding]; other site
196162012590	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
196162012591	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
196162012592	inhibitor-cofactor binding pocket; inhibition site
196162012593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162012594	catalytic residue [active]
196162012595	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
196162012596	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
196162012597	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
196162012598	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
196162012599	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
196162012600	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
196162012601	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
196162012602	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
196162012603	putative ADP-binding pocket [chemical binding]; other site
196162012604	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162012605	Methyltransferase domain; Region: Methyltransf_31; pfam13847
196162012606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162012607	S-adenosylmethionine binding site [chemical binding]; other site
196162012608	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
196162012609	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
196162012610	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162012611	S-adenosylmethionine binding site [chemical binding]; other site
196162012612	Bacterial sugar transferase; Region: Bac_transf; pfam02397
196162012613	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
196162012614	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
196162012615	inhibitor-cofactor binding pocket; inhibition site
196162012616	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162012617	catalytic residue [active]
196162012618	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
196162012619	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
196162012620	PYR/PP interface [polypeptide binding]; other site
196162012621	dimer interface [polypeptide binding]; other site
196162012622	TPP binding site [chemical binding]; other site
196162012623	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196162012624	transketolase; Reviewed; Region: PRK05899
196162012625	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
196162012626	TPP-binding site [chemical binding]; other site
196162012627	dimer interface [polypeptide binding]; other site
196162012628	Methyltransferase domain; Region: Methyltransf_24; pfam13578
196162012629	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
196162012630	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
196162012631	D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273
196162012632	dimerization interface [polypeptide binding]; other site
196162012633	putative tRNAtyr binding site [nucleotide binding]; other site
196162012634	putative active site [active]
196162012635	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
196162012636	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
196162012637	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
196162012638	active site residue [active]
196162012639	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
196162012640	active site residue [active]
196162012641	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
196162012642	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
196162012643	catalytic residues [active]
196162012644	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
196162012645	DNA binding residues [nucleotide binding]
196162012646	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196162012647	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
196162012648	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
196162012649	putative dimer interface [polypeptide binding]; other site
196162012650	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
196162012651	Catalytic site [active]
196162012652	alternate signal-mediated exported protein, RER_14450 family; Region: exp_by_SipW_III; TIGR04089
196162012653	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
196162012654	MoaE interaction surface [polypeptide binding]; other site
196162012655	MoeB interaction surface [polypeptide binding]; other site
196162012656	thiocarboxylated glycine; other site
196162012657	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
196162012658	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162012659	DNA binding site [nucleotide binding]
196162012660	MMPL family; Region: MMPL; pfam03176
196162012661	MMPL family; Region: MMPL; pfam03176
196162012662	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
196162012663	active site
196162012664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162012665	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162012666	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162012667	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162012668	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
196162012669	nucleophilic elbow; other site
196162012670	catalytic triad; other site
196162012671	MMPL family; Region: MMPL; pfam03176
196162012672	MMPL family; Region: MMPL; pfam03176
196162012673	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
196162012674	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162012675	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
196162012676	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
196162012677	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
196162012678	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
196162012679	metal binding site 2 [ion binding]; metal-binding site
196162012680	putative DNA binding helix; other site
196162012681	metal binding site 1 [ion binding]; metal-binding site
196162012682	dimer interface [polypeptide binding]; other site
196162012683	structural Zn2+ binding site [ion binding]; other site
196162012684	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
196162012685	heme-binding site [chemical binding]; other site
196162012686	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
196162012687	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
196162012688	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
196162012689	polyphosphate kinase; Provisional; Region: PRK05443
196162012690	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
196162012691	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
196162012692	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
196162012693	putative domain interface [polypeptide binding]; other site
196162012694	putative active site [active]
196162012695	catalytic site [active]
196162012696	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
196162012697	putative domain interface [polypeptide binding]; other site
196162012698	putative active site [active]
196162012699	catalytic site [active]
196162012700	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
196162012701	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
196162012702	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
196162012703	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
196162012704	Walker A/P-loop; other site
196162012705	ATP binding site [chemical binding]; other site
196162012706	Q-loop/lid; other site
196162012707	ABC transporter signature motif; other site
196162012708	Walker B; other site
196162012709	D-loop; other site
196162012710	H-loop/switch region; other site
196162012711	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
196162012712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162012713	dimer interface [polypeptide binding]; other site
196162012714	conserved gate region; other site
196162012715	putative PBP binding loops; other site
196162012716	ABC-ATPase subunit interface; other site
196162012717	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
196162012718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162012719	dimer interface [polypeptide binding]; other site
196162012720	conserved gate region; other site
196162012721	putative PBP binding loops; other site
196162012722	ABC-ATPase subunit interface; other site
196162012723	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
196162012724	PBP superfamily domain; Region: PBP_like_2; cl17296
196162012725	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
196162012726	active site
196162012727	Ap6A binding site [chemical binding]; other site
196162012728	nudix motif; other site
196162012729	metal binding site [ion binding]; metal-binding site
196162012730	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162012731	catalytic core [active]
196162012732	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
196162012733	putative homodimer interface [polypeptide binding]; other site
196162012734	putative homotetramer interface [polypeptide binding]; other site
196162012735	putative allosteric switch controlling residues; other site
196162012736	putative metal binding site [ion binding]; other site
196162012737	putative homodimer-homodimer interface [polypeptide binding]; other site
196162012738	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
196162012739	DNA-binding site [nucleotide binding]; DNA binding site
196162012740	RNA-binding motif; other site
196162012741	Amidohydrolase ring-opening protein (Amido_AtzD_TrzD); Region: Amido_AtzD_TrzD; pfam09663
196162012742	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162012743	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162012744	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162012745	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162012746	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162012747	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
196162012748	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390
196162012749	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196162012750	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012751	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162012752	Domain of unknown function (DUF336); Region: DUF336; cl01249
196162012753	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
196162012754	homotrimer interaction site [polypeptide binding]; other site
196162012755	putative active site [active]
196162012756	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
196162012757	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
196162012758	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
196162012759	[2Fe-2S] cluster binding site [ion binding]; other site
196162012760	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162012761	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162012762	NAD(P) binding site [chemical binding]; other site
196162012763	catalytic residues [active]
196162012764	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
196162012765	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162012766	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
196162012767	iron-sulfur cluster [ion binding]; other site
196162012768	[2Fe-2S] cluster binding site [ion binding]; other site
196162012769	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
196162012770	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
196162012771	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
196162012772	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
196162012773	CoenzymeA binding site [chemical binding]; other site
196162012774	subunit interaction site [polypeptide binding]; other site
196162012775	PHB binding site; other site
196162012776	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
196162012777	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162012778	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
196162012779	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
196162012780	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
196162012781	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012782	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012783	active site
196162012784	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162012785	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012786	active site
196162012787	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
196162012788	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162012789	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162012790	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
196162012791	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162012792	substrate binding site [chemical binding]; other site
196162012793	oxyanion hole (OAH) forming residues; other site
196162012794	trimer interface [polypeptide binding]; other site
196162012795	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
196162012796	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
196162012797	acyl-activating enzyme (AAE) consensus motif; other site
196162012798	putative AMP binding site [chemical binding]; other site
196162012799	putative active site [active]
196162012800	putative CoA binding site [chemical binding]; other site
196162012801	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
196162012802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162012803	NAD(P) binding site [chemical binding]; other site
196162012804	active site
196162012805	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
196162012806	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162012807	active site
196162012808	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162012809	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
196162012810	substrate binding site [chemical binding]; other site
196162012811	oxyanion hole (OAH) forming residues; other site
196162012812	trimer interface [polypeptide binding]; other site
196162012813	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162012814	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162012815	Ferredoxin [Energy production and conversion]; Region: COG1146
196162012816	4Fe-4S binding domain; Region: Fer4; pfam00037
196162012817	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162012818	Predicted transcriptional regulator [Transcription]; Region: COG2345
196162012819	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162012820	putative DNA binding site [nucleotide binding]; other site
196162012821	putative Zn2+ binding site [ion binding]; other site
196162012822	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
196162012823	trimer interface [polypeptide binding]; other site
196162012824	active site
196162012825	substrate binding site [chemical binding]; other site
196162012826	CoA binding site [chemical binding]; other site
196162012827	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
196162012828	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
196162012829	dimer interface [polypeptide binding]; other site
196162012830	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162012831	catalytic residue [active]
196162012832	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162012833	PAS domain; Region: PAS_9; pfam13426
196162012834	putative active site [active]
196162012835	heme pocket [chemical binding]; other site
196162012836	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
196162012837	PAS fold; Region: PAS_3; pfam08447
196162012838	putative active site [active]
196162012839	heme pocket [chemical binding]; other site
196162012840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162012841	GAF domain; Region: GAF; cl17456
196162012842	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162012843	dimer interface [polypeptide binding]; other site
196162012844	phosphorylation site [posttranslational modification]
196162012845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162012846	ATP binding site [chemical binding]; other site
196162012847	Mg2+ binding site [ion binding]; other site
196162012848	G-X-G motif; other site
196162012849	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
196162012850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162012851	active site
196162012852	phosphorylation site [posttranslational modification]
196162012853	intermolecular recognition site; other site
196162012854	dimerization interface [polypeptide binding]; other site
196162012855	Response regulator receiver domain; Region: Response_reg; pfam00072
196162012856	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162012857	active site
196162012858	phosphorylation site [posttranslational modification]
196162012859	intermolecular recognition site; other site
196162012860	dimerization interface [polypeptide binding]; other site
196162012861	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
196162012862	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
196162012863	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
196162012864	NAD binding site [chemical binding]; other site
196162012865	Phe binding site; other site
196162012866	Protein of unknown function (DUF3073); Region: DUF3073; pfam11273
196162012867	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
196162012868	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
196162012869	dimerization interface [polypeptide binding]; other site
196162012870	putative ATP binding site [chemical binding]; other site
196162012871	amidophosphoribosyltransferase; Provisional; Region: PRK07847
196162012872	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
196162012873	active site
196162012874	tetramer interface [polypeptide binding]; other site
196162012875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162012876	active site
196162012877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162012878	dimer interface [polypeptide binding]; other site
196162012879	phosphorylation site [posttranslational modification]
196162012880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162012881	ATP binding site [chemical binding]; other site
196162012882	Mg2+ binding site [ion binding]; other site
196162012883	G-X-G motif; other site
196162012884	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162012885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162012886	dimer interface [polypeptide binding]; other site
196162012887	phosphorylation site [posttranslational modification]
196162012888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162012889	ATP binding site [chemical binding]; other site
196162012890	Mg2+ binding site [ion binding]; other site
196162012891	G-X-G motif; other site
196162012892	hypothetical protein; Provisional; Region: PRK07907
196162012893	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
196162012894	active site
196162012895	metal binding site [ion binding]; metal-binding site
196162012896	dimer interface [polypeptide binding]; other site
196162012897	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162012898	dimerization interface [polypeptide binding]; other site
196162012899	putative DNA binding site [nucleotide binding]; other site
196162012900	putative Zn2+ binding site [ion binding]; other site
196162012901	H+ Antiporter protein; Region: 2A0121; TIGR00900
196162012902	Predicted transcriptional regulator [Transcription]; Region: COG2378
196162012903	HTH domain; Region: HTH_11; pfam08279
196162012904	WYL domain; Region: WYL; pfam13280
196162012905	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
196162012906	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162012907	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
196162012908	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
196162012909	dimerization interface [polypeptide binding]; other site
196162012910	ATP binding site [chemical binding]; other site
196162012911	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
196162012912	dimerization interface [polypeptide binding]; other site
196162012913	ATP binding site [chemical binding]; other site
196162012914	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162012915	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162012916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162012917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012918	putative substrate translocation pore; other site
196162012919	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
196162012920	active site
196162012921	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
196162012922	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
196162012923	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
196162012924	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
196162012925	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
196162012926	putative active site [active]
196162012927	catalytic triad [active]
196162012928	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
196162012929	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
196162012930	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
196162012931	acyl-activating enzyme (AAE) consensus motif; other site
196162012932	putative AMP binding site [chemical binding]; other site
196162012933	putative active site [active]
196162012934	putative CoA binding site [chemical binding]; other site
196162012935	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
196162012936	hydrophobic ligand binding site; other site
196162012937	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
196162012938	ATP binding site [chemical binding]; other site
196162012939	active site
196162012940	substrate binding site [chemical binding]; other site
196162012941	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
196162012942	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
196162012943	putative transporter; Provisional; Region: PRK10504
196162012944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012945	putative substrate translocation pore; other site
196162012946	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012947	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
196162012948	adenylosuccinate lyase; Region: purB; TIGR00928
196162012949	tetramer interface [polypeptide binding]; other site
196162012950	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
196162012951	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
196162012952	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162012953	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
196162012954	Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153
196162012955	putative heme binding pocket [chemical binding]; other site
196162012956	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
196162012957	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
196162012958	GDP-binding site [chemical binding]; other site
196162012959	ACT binding site; other site
196162012960	IMP binding site; other site
196162012961	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
196162012962	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
196162012963	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
196162012964	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162012965	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162012966	dimerization interface [polypeptide binding]; other site
196162012967	DNA binding residues [nucleotide binding]
196162012968	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
196162012969	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
196162012970	putative anticodon binding site; other site
196162012971	dimer interface [polypeptide binding]; other site
196162012972	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
196162012973	motif 1; other site
196162012974	dimer interface [polypeptide binding]; other site
196162012975	active site
196162012976	motif 2; other site
196162012977	motif 3; other site
196162012978	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
196162012979	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012980	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162012981	putative substrate translocation pore; other site
196162012982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162012983	putative substrate translocation pore; other site
196162012984	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
196162012985	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
196162012986	active site
196162012987	intersubunit interface [polypeptide binding]; other site
196162012988	zinc binding site [ion binding]; other site
196162012989	Na+ binding site [ion binding]; other site
196162012990	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
196162012991	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
196162012992	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
196162012993	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
196162012994	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
196162012995	active site
196162012996	aminotransferase; Validated; Region: PRK07777
196162012997	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162012998	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162012999	homodimer interface [polypeptide binding]; other site
196162013000	catalytic residue [active]
196162013001	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
196162013002	Clp amino terminal domain; Region: Clp_N; pfam02861
196162013003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162013004	Walker A motif; other site
196162013005	ATP binding site [chemical binding]; other site
196162013006	Walker B motif; other site
196162013007	arginine finger; other site
196162013008	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
196162013009	Walker A motif; other site
196162013010	ATP binding site [chemical binding]; other site
196162013011	Walker B motif; other site
196162013012	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
196162013013	Response regulator receiver domain; Region: Response_reg; pfam00072
196162013014	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162013015	active site
196162013016	phosphorylation site [posttranslational modification]
196162013017	intermolecular recognition site; other site
196162013018	dimerization interface [polypeptide binding]; other site
196162013019	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162013020	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162013021	dimer interface [polypeptide binding]; other site
196162013022	phosphorylation site [posttranslational modification]
196162013023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162013024	ATP binding site [chemical binding]; other site
196162013025	Mg2+ binding site [ion binding]; other site
196162013026	G-X-G motif; other site
196162013027	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
196162013028	DNA binding residues [nucleotide binding]
196162013029	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
196162013030	putative dimer interface [polypeptide binding]; other site
196162013031	chaperone protein DnaJ; Provisional; Region: PRK14295
196162013032	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
196162013033	HSP70 interaction site [polypeptide binding]; other site
196162013034	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
196162013035	Zn binding sites [ion binding]; other site
196162013036	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
196162013037	dimer interface [polypeptide binding]; other site
196162013038	GrpE; Region: GrpE; pfam01025
196162013039	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
196162013040	dimer interface [polypeptide binding]; other site
196162013041	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
196162013042	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
196162013043	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
196162013044	nucleotide binding site [chemical binding]; other site
196162013045	NEF interaction site [polypeptide binding]; other site
196162013046	SBD interface [polypeptide binding]; other site
196162013047	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
196162013048	aspartate racemase; Region: asp_race; TIGR00035
196162013049	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
196162013050	MarR family; Region: MarR_2; pfam12802
196162013051	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
196162013052	EamA-like transporter family; Region: EamA; pfam00892
196162013053	SnoaL-like domain; Region: SnoaL_4; pfam13577
196162013054	SnoaL-like domain; Region: SnoaL_3; pfam13474
196162013055	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
196162013056	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
196162013057	short chain dehydrogenase; Provisional; Region: PRK07890
196162013058	classical (c) SDRs; Region: SDR_c; cd05233
196162013059	NAD(P) binding site [chemical binding]; other site
196162013060	active site
196162013061	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
196162013062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162013063	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162013064	NAD(P) binding site [chemical binding]; other site
196162013065	active site
196162013066	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162013067	Cytochrome P450; Region: p450; cl12078
196162013068	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
196162013069	putative dimer interface [polypeptide binding]; other site
196162013070	putative [2Fe-2S] cluster binding site [ion binding]; other site
196162013071	Cupin superfamily protein; Region: Cupin_4; pfam08007
196162013072	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
196162013073	putative dimer interface [polypeptide binding]; other site
196162013074	putative [2Fe-2S] cluster binding site [ion binding]; other site
196162013075	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
196162013076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
196162013077	FeS/SAM binding site; other site
196162013078	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
196162013079	TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903
196162013080	AAA ATPase domain; Region: AAA_16; pfam13191
196162013081	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162013082	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162013083	DNA binding residues [nucleotide binding]
196162013084	dimerization interface [polypeptide binding]; other site
196162013085	Cupin; Region: Cupin_6; pfam12852
196162013086	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
196162013087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
196162013088	Protein of unknown function (DUF4242); Region: DUF4242; pfam14026
196162013089	imidazolonepropionase; Provisional; Region: PRK14085
196162013090	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
196162013091	active site
196162013092	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
196162013093	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162013094	active site
196162013095	allantoate amidohydrolase; Reviewed; Region: PRK09290
196162013096	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
196162013097	active site
196162013098	metal binding site [ion binding]; metal-binding site
196162013099	dimer interface [polypeptide binding]; other site
196162013100	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
196162013101	putative FMN binding site [chemical binding]; other site
196162013102	hypothetical protein; Provisional; Region: PRK08262
196162013103	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
196162013104	metal binding site [ion binding]; metal-binding site
196162013105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162013106	putative substrate translocation pore; other site
196162013107	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
196162013108	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
196162013109	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162013110	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162013111	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
196162013112	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
196162013113	Peptidase family M48; Region: Peptidase_M48; cl12018
196162013114	urocanate hydratase; Provisional; Region: PRK05414
196162013115	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
196162013116	active sites [active]
196162013117	tetramer interface [polypeptide binding]; other site
196162013118	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
196162013119	Transcriptional regulator [Transcription]; Region: IclR; COG1414
196162013120	Bacterial transcriptional regulator; Region: IclR; pfam01614
196162013121	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
196162013122	4Fe-4S binding domain; Region: Fer4; pfam00037
196162013123	Cysteine-rich domain; Region: CCG; pfam02754
196162013124	Cysteine-rich domain; Region: CCG; pfam02754
196162013125	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
196162013126	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478
196162013127	Na binding site [ion binding]; other site
196162013128	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
196162013129	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
196162013130	Siderophore-interacting FAD-binding domain; Region: FAD_binding_9; pfam08021
196162013131	Siderophore-interacting protein; Region: SIP; pfam04954
196162013132	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
196162013133	trimer interface [polypeptide binding]; other site
196162013134	active site
196162013135	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832
196162013136	active site
196162013137	catalytic triad [active]
196162013138	oxyanion hole [active]
196162013139	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
196162013140	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
196162013141	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
196162013142	Rrf2 family protein; Region: rrf2_super; TIGR00738
196162013143	Transcriptional regulator; Region: Rrf2; pfam02082
196162013144	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
196162013145	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162013146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162013147	active site
196162013148	phosphorylation site [posttranslational modification]
196162013149	intermolecular recognition site; other site
196162013150	dimerization interface [polypeptide binding]; other site
196162013151	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162013152	DNA binding site [nucleotide binding]
196162013153	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162013154	dimerization interface [polypeptide binding]; other site
196162013155	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162013156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162013157	dimer interface [polypeptide binding]; other site
196162013158	phosphorylation site [posttranslational modification]
196162013159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162013160	ATP binding site [chemical binding]; other site
196162013161	Mg2+ binding site [ion binding]; other site
196162013162	G-X-G motif; other site
196162013163	ApbE family; Region: ApbE; pfam02424
196162013164	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
196162013165	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
196162013166	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
196162013167	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
196162013168	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
196162013169	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162013170	active site
196162013171	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
196162013172	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
196162013173	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
196162013174	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
196162013175	dimerization interface [polypeptide binding]; other site
196162013176	Lysine efflux permease [General function prediction only]; Region: COG1279
196162013177	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
196162013178	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162013179	short chain dehydrogenase; Provisional; Region: PRK06197
196162013180	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162013181	NAD(P) binding site [chemical binding]; other site
196162013182	active site
196162013183	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
196162013184	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
196162013185	active site
196162013186	catalytic tetrad [active]
196162013187	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
196162013188	phosphoglucomutase; Validated; Region: PRK07564
196162013189	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
196162013190	active site
196162013191	substrate binding site [chemical binding]; other site
196162013192	metal binding site [ion binding]; metal-binding site
196162013193	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
196162013194	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
196162013195	Walker A/P-loop; other site
196162013196	ATP binding site [chemical binding]; other site
196162013197	Q-loop/lid; other site
196162013198	ABC transporter signature motif; other site
196162013199	Walker B; other site
196162013200	D-loop; other site
196162013201	H-loop/switch region; other site
196162013202	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
196162013203	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
196162013204	TM-ABC transporter signature motif; other site
196162013205	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
196162013206	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
196162013207	Walker A/P-loop; other site
196162013208	ATP binding site [chemical binding]; other site
196162013209	Q-loop/lid; other site
196162013210	ABC transporter signature motif; other site
196162013211	Walker B; other site
196162013212	D-loop; other site
196162013213	H-loop/switch region; other site
196162013214	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
196162013215	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
196162013216	TM-ABC transporter signature motif; other site
196162013217	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
196162013218	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338
196162013219	putative ligand binding site [chemical binding]; other site
196162013220	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
196162013221	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162013222	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162013223	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162013224	Walker A/P-loop; other site
196162013225	ATP binding site [chemical binding]; other site
196162013226	Q-loop/lid; other site
196162013227	ABC transporter signature motif; other site
196162013228	Walker B; other site
196162013229	D-loop; other site
196162013230	H-loop/switch region; other site
196162013231	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162013232	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
196162013233	Walker A/P-loop; other site
196162013234	ATP binding site [chemical binding]; other site
196162013235	Q-loop/lid; other site
196162013236	ABC transporter signature motif; other site
196162013237	Walker B; other site
196162013238	D-loop; other site
196162013239	H-loop/switch region; other site
196162013240	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
196162013241	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162013242	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162013243	DNA binding residues [nucleotide binding]
196162013244	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895
196162013245	putative hydrophobic ligand binding site [chemical binding]; other site
196162013246	Methyltransferase domain; Region: Methyltransf_23; pfam13489
196162013247	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162013248	S-adenosylmethionine binding site [chemical binding]; other site
196162013249	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
196162013250	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196162013251	E3 interaction surface; other site
196162013252	lipoyl attachment site [posttranslational modification]; other site
196162013253	e3 binding domain; Region: E3_binding; pfam02817
196162013254	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
196162013255	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
196162013256	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
196162013257	tetramer interface [polypeptide binding]; other site
196162013258	TPP-binding site [chemical binding]; other site
196162013259	heterodimer interface [polypeptide binding]; other site
196162013260	phosphorylation loop region [posttranslational modification]
196162013261	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
196162013262	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
196162013263	alpha subunit interface [polypeptide binding]; other site
196162013264	TPP binding site [chemical binding]; other site
196162013265	heterodimer interface [polypeptide binding]; other site
196162013266	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196162013267	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
196162013268	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162013269	active site
196162013270	metal binding site [ion binding]; metal-binding site
196162013271	Transcriptional regulators [Transcription]; Region: FadR; COG2186
196162013272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
196162013273	DNA-binding site [nucleotide binding]; DNA binding site
196162013274	FCD domain; Region: FCD; pfam07729
196162013275	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
196162013276	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162013277	catalytic loop [active]
196162013278	iron binding site [ion binding]; other site
196162013279	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
196162013280	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162013281	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
196162013282	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162013283	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
196162013284	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
196162013285	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
196162013286	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
196162013287	putative NAD(P) binding site [chemical binding]; other site
196162013288	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
196162013289	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
196162013290	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162013291	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162013292	putative substrate translocation pore; other site
196162013293	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
196162013294	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
196162013295	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
196162013296	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196162013297	Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899
196162013298	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
196162013299	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
196162013300	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
196162013301	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
196162013302	dimerization interface [polypeptide binding]; other site
196162013303	putative DNA binding site [nucleotide binding]; other site
196162013304	putative Zn2+ binding site [ion binding]; other site
196162013305	Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821
196162013306	active site
196162013307	metal-binding site [ion binding]
196162013308	nucleotide-binding site [chemical binding]; other site
196162013309	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
196162013310	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196162013311	tetramerization interface [polypeptide binding]; other site
196162013312	NAD(P) binding site [chemical binding]; other site
196162013313	catalytic residues [active]
196162013314	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
196162013315	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
196162013316	active site
196162013317	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
196162013318	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
196162013319	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
196162013320	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
196162013321	Major Facilitator Superfamily; Region: MFS_1; pfam07690
196162013322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162013323	putative substrate translocation pore; other site
196162013324	Transcriptional regulators [Transcription]; Region: PurR; COG1609
196162013325	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
196162013326	DNA binding site [nucleotide binding]
196162013327	domain linker motif; other site
196162013328	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
196162013329	dimerization interface [polypeptide binding]; other site
196162013330	ligand binding site [chemical binding]; other site
196162013331	Fatty acid desaturase; Region: FA_desaturase; pfam00487
196162013332	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
196162013333	putative di-iron ligands [ion binding]; other site
196162013334	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
196162013335	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
196162013336	FAD binding pocket [chemical binding]; other site
196162013337	FAD binding motif [chemical binding]; other site
196162013338	phosphate binding motif [ion binding]; other site
196162013339	beta-alpha-beta structure motif; other site
196162013340	NAD binding pocket [chemical binding]; other site
196162013341	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
196162013342	catalytic loop [active]
196162013343	iron binding site [ion binding]; other site
196162013344	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162013345	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
196162013346	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
196162013347	active site
196162013348	trimer interface [polypeptide binding]; other site
196162013349	allosteric site; other site
196162013350	active site lid [active]
196162013351	hexamer (dimer of trimers) interface [polypeptide binding]; other site
196162013352	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
196162013353	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162013354	active site
196162013355	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162013356	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
196162013357	nucleotide binding site [chemical binding]; other site
196162013358	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196162013359	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
196162013360	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162013361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
196162013362	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162013363	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162013364	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
196162013365	Cation efflux family; Region: Cation_efflux; pfam01545
196162013366	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
196162013367	active site
196162013368	catalytic triad [active]
196162013369	oxyanion hole [active]
196162013370	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162013371	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
196162013372	Amidohydrolase family; Region: Amidohydro_3; pfam07969
196162013373	active site
196162013374	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
196162013375	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
196162013376	putative substrate translocation pore; other site
196162013377	Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127
196162013378	phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288
196162013379	NADP binding site [chemical binding]; other site
196162013380	catalytic residues [active]
196162013381	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
196162013382	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
196162013383	putative metal binding site [ion binding]; other site
196162013384	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162013385	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162013386	active site
196162013387	ATP binding site [chemical binding]; other site
196162013388	substrate binding site [chemical binding]; other site
196162013389	activation loop (A-loop); other site
196162013390	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
196162013391	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
196162013392	Walker A/P-loop; other site
196162013393	ATP binding site [chemical binding]; other site
196162013394	Q-loop/lid; other site
196162013395	ABC transporter signature motif; other site
196162013396	Walker B; other site
196162013397	D-loop; other site
196162013398	H-loop/switch region; other site
196162013399	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
196162013400	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
196162013401	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
196162013402	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162013403	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162013404	DNA binding residues [nucleotide binding]
196162013405	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
196162013406	Zn binding site [ion binding]; other site
196162013407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162013408	NADH(P)-binding; Region: NAD_binding_10; pfam13460
196162013409	NAD(P) binding site [chemical binding]; other site
196162013410	active site
196162013411	Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777
196162013412	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196162013413	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196162013414	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162013415	NAD(P) binding site [chemical binding]; other site
196162013416	active site
196162013417	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
196162013418	hypothetical protein; Provisional; Region: PRK10279
196162013419	active site
196162013420	nucleophile elbow; other site
196162013421	Protein of unknown function (DUF2804); Region: DUF2804; pfam10974
196162013422	acetylornithine deacetylase; Validated; Region: PRK06915
196162013423	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895
196162013424	metal binding site [ion binding]; metal-binding site
196162013425	dimer interface [polypeptide binding]; other site
196162013426	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
196162013427	E3 interaction surface; other site
196162013428	lipoyl attachment site [posttranslational modification]; other site
196162013429	e3 binding domain; Region: E3_binding; pfam02817
196162013430	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
196162013431	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
196162013432	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
196162013433	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
196162013434	alpha subunit interface [polypeptide binding]; other site
196162013435	TPP binding site [chemical binding]; other site
196162013436	heterodimer interface [polypeptide binding]; other site
196162013437	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
196162013438	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
196162013439	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
196162013440	TPP-binding site [chemical binding]; other site
196162013441	heterodimer interface [polypeptide binding]; other site
196162013442	tetramer interface [polypeptide binding]; other site
196162013443	phosphorylation loop region [posttranslational modification]
196162013444	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
196162013445	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
196162013446	active site
196162013447	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
196162013448	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
196162013449	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
196162013450	putative dimer interface [polypeptide binding]; other site
196162013451	N-terminal domain interface [polypeptide binding]; other site
196162013452	putative substrate binding pocket (H-site) [chemical binding]; other site
196162013453	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
196162013454	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
196162013455	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
196162013456	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162013457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162013458	homodimer interface [polypeptide binding]; other site
196162013459	catalytic residue [active]
196162013460	Membrane protein of unknown function; Region: DUF360; pfam04020
196162013461	Low molecular weight phosphatase family; Region: LMWPc; cd00115
196162013462	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
196162013463	active site
196162013464	Fructosamine kinase; Region: Fructosamin_kin; cl17579
196162013465	Phosphotransferase enzyme family; Region: APH; pfam01636
196162013466	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
196162013467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
196162013468	active site
196162013469	phosphorylation site [posttranslational modification]
196162013470	intermolecular recognition site; other site
196162013471	dimerization interface [polypeptide binding]; other site
196162013472	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
196162013473	DNA binding site [nucleotide binding]
196162013474	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
196162013475	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
196162013476	dimerization interface [polypeptide binding]; other site
196162013477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
196162013478	dimer interface [polypeptide binding]; other site
196162013479	phosphorylation site [posttranslational modification]
196162013480	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
196162013481	ATP binding site [chemical binding]; other site
196162013482	Mg2+ binding site [ion binding]; other site
196162013483	G-X-G motif; other site
196162013484	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
196162013485	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
196162013486	CoenzymeA binding site [chemical binding]; other site
196162013487	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
196162013488	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162013489	inhibitor-cofactor binding pocket; inhibition site
196162013490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162013491	catalytic residue [active]
196162013492	BNR repeat-like domain; Region: BNR_2; pfam13088
196162013493	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162013494	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162013495	glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854
196162013496	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
196162013497	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
196162013498	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
196162013499	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
196162013500	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
196162013501	Glutamine amidotransferase class-I; Region: GATase; pfam00117
196162013502	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
196162013503	glutamine binding [chemical binding]; other site
196162013504	catalytic triad [active]
196162013505	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
196162013506	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
196162013507	Glutamine amidotransferase class-I; Region: GATase; pfam00117
196162013508	glutamine binding [chemical binding]; other site
196162013509	catalytic triad [active]
196162013510	Part of AAA domain; Region: AAA_19; pfam13245
196162013511	enoyl-CoA hydratase; Provisional; Region: PRK07827
196162013512	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162013513	substrate binding site [chemical binding]; other site
196162013514	oxyanion hole (OAH) forming residues; other site
196162013515	trimer interface [polypeptide binding]; other site
196162013516	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
196162013517	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
196162013518	Moco binding site; other site
196162013519	metal coordination site [ion binding]; other site
196162013520	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
196162013521	Fasciclin domain; Region: Fasciclin; pfam02469
196162013522	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
196162013523	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162013524	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162013525	DNA binding residues [nucleotide binding]
196162013526	Putative zinc-finger; Region: zf-HC2; pfam13490
196162013527	putative anti-sigmaE protein; Provisional; Region: PRK13920
196162013528	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
196162013529	Anti-sigma-K factor rskA; Region: RskA; pfam10099
196162013530	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
196162013531	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
196162013532	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
196162013533	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
196162013534	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
196162013535	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162013536	S-adenosylmethionine binding site [chemical binding]; other site
196162013537	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
196162013538	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
196162013539	protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944
196162013540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162013541	S-adenosylmethionine binding site [chemical binding]; other site
196162013542	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
196162013543	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
196162013544	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
196162013545	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
196162013546	active site
196162013547	FMN binding site [chemical binding]; other site
196162013548	substrate binding site [chemical binding]; other site
196162013549	putative catalytic residue [active]
196162013550	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196162013551	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
196162013552	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162013553	S-adenosylmethionine binding site [chemical binding]; other site
196162013554	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
196162013555	DNA polymerase IV; Validated; Region: PRK03858
196162013556	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
196162013557	active site
196162013558	DNA binding site [nucleotide binding]
196162013559	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162013560	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
196162013561	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
196162013562	active site
196162013563	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
196162013564	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
196162013565	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162013566	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
196162013567	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
196162013568	carboxyltransferase (CT) interaction site; other site
196162013569	biotinylation site [posttranslational modification]; other site
196162013570	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
196162013571	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
196162013572	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
196162013573	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
196162013574	hydrophobic ligand binding site; other site
196162013575	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162013576	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162013577	active site
196162013578	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
196162013579	TIGR03084 family protein; Region: TIGR03084
196162013580	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162013581	Wyosine base formation; Region: Wyosine_form; pfam08608
196162013582	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
196162013583	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162013584	RDD family; Region: RDD; pfam06271
196162013585	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
196162013586	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
196162013587	catalytic core [active]
196162013588	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
196162013589	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
196162013590	Potassium binding sites [ion binding]; other site
196162013591	Cesium cation binding sites [ion binding]; other site
196162013592	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
196162013593	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
196162013594	substrate binding site [chemical binding]; other site
196162013595	oxyanion hole (OAH) forming residues; other site
196162013596	trimer interface [polypeptide binding]; other site
196162013597	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162013598	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
196162013599	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
196162013600	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
196162013601	dimer interface [polypeptide binding]; other site
196162013602	active site
196162013603	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
196162013604	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
196162013605	NAD(P) binding site [chemical binding]; other site
196162013606	active site
196162013607	CAAX protease self-immunity; Region: Abi; cl00558
196162013608	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
196162013609	DEAD-like helicases superfamily; Region: DEXDc; smart00487
196162013610	ATP binding site [chemical binding]; other site
196162013611	Mg++ binding site [ion binding]; other site
196162013612	motif III; other site
196162013613	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162013614	nucleotide binding region [chemical binding]; other site
196162013615	ATP-binding site [chemical binding]; other site
196162013616	CsbD-like; Region: CsbD; pfam05532
196162013617	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
196162013618	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
196162013619	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
196162013620	catalytic triad [active]
196162013621	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
196162013622	CoA-transferase family III; Region: CoA_transf_3; pfam02515
196162013623	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
196162013624	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
196162013625	Walker A/P-loop; other site
196162013626	ATP binding site [chemical binding]; other site
196162013627	Q-loop/lid; other site
196162013628	ABC transporter signature motif; other site
196162013629	Walker B; other site
196162013630	D-loop; other site
196162013631	H-loop/switch region; other site
196162013632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162013633	dimer interface [polypeptide binding]; other site
196162013634	conserved gate region; other site
196162013635	putative PBP binding loops; other site
196162013636	ABC-ATPase subunit interface; other site
196162013637	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
196162013638	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
196162013639	substrate binding pocket [chemical binding]; other site
196162013640	membrane-bound complex binding site; other site
196162013641	hinge residues; other site
196162013642	Predicted transcriptional regulators [Transcription]; Region: COG1695
196162013643	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
196162013644	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
196162013645	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
196162013646	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
196162013647	active site
196162013648	FMN binding site [chemical binding]; other site
196162013649	2,4-decadienoyl-CoA binding site; other site
196162013650	catalytic residue [active]
196162013651	4Fe-4S cluster binding site [ion binding]; other site
196162013652	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
196162013653	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
196162013654	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162013655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162013656	homodimer interface [polypeptide binding]; other site
196162013657	catalytic residue [active]
196162013658	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
196162013659	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
196162013660	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
196162013661	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
196162013662	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
196162013663	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
196162013664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551
196162013665	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
196162013666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
196162013667	active site
196162013668	Methyltransferase domain; Region: Methyltransf_24; pfam13578
196162013669	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
196162013670	beta-galactosidase; Region: BGL; TIGR03356
196162013671	putative lipid kinase; Reviewed; Region: PRK13057
196162013672	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
196162013673	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
196162013674	FAD binding domain; Region: FAD_binding_4; pfam01565
196162013675	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
196162013676	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
196162013677	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
196162013678	RNA polymerase factor sigma-70; Validated; Region: PRK08241
196162013679	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162013680	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162013681	DNA binding residues [nucleotide binding]
196162013682	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
196162013683	TIGR03086 family protein; Region: TIGR03086
196162013684	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
196162013685	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
196162013686	dimerization interface [polypeptide binding]; other site
196162013687	DNA binding residues [nucleotide binding]
196162013688	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
196162013689	succinic semialdehyde dehydrogenase; Region: PLN02278
196162013690	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
196162013691	tetramerization interface [polypeptide binding]; other site
196162013692	NAD(P) binding site [chemical binding]; other site
196162013693	catalytic residues [active]
196162013694	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
196162013695	elongation factor G; Reviewed; Region: PRK12740
196162013696	G1 box; other site
196162013697	putative GEF interaction site [polypeptide binding]; other site
196162013698	GTP/Mg2+ binding site [chemical binding]; other site
196162013699	Switch I region; other site
196162013700	G2 box; other site
196162013701	G3 box; other site
196162013702	Switch II region; other site
196162013703	G4 box; other site
196162013704	G5 box; other site
196162013705	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
196162013706	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
196162013707	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
196162013708	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
196162013709	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
196162013710	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
196162013711	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
196162013712	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
196162013713	ATP binding site [chemical binding]; other site
196162013714	Mg++ binding site [ion binding]; other site
196162013715	motif III; other site
196162013716	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
196162013717	nucleotide binding region [chemical binding]; other site
196162013718	ATP-binding site [chemical binding]; other site
196162013719	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
196162013720	putative RNA binding site [nucleotide binding]; other site
196162013721	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
196162013722	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
196162013723	glutaminase active site [active]
196162013724	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
196162013725	dimer interface [polypeptide binding]; other site
196162013726	active site
196162013727	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
196162013728	dimer interface [polypeptide binding]; other site
196162013729	active site
196162013730	Uncharacterized conserved protein [Function unknown]; Region: COG2353
196162013731	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
196162013732	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162013733	Coenzyme A binding pocket [chemical binding]; other site
196162013734	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162013735	Coenzyme A binding pocket [chemical binding]; other site
196162013736	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
196162013737	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
196162013738	active site
196162013739	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
196162013740	Na binding site [ion binding]; other site
196162013741	Protein of unknown function (DUF3311); Region: DUF3311; pfam11755
196162013742	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
196162013743	Predicted transcriptional regulators [Transcription]; Region: COG1695
196162013744	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
196162013745	Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455
196162013746	active site
196162013747	Zn binding site [ion binding]; other site
196162013748	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
196162013749	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
196162013750	DNA binding residues [nucleotide binding]
196162013751	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
196162013752	active site
196162013753	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
196162013754	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
196162013755	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
196162013756	enterobactin exporter EntS; Provisional; Region: PRK10489
196162013757	DinB superfamily; Region: DinB_2; pfam12867
196162013758	Protein of unknown function (DUF664); Region: DUF664; pfam04978
196162013759	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
196162013760	Cytochrome P450; Region: p450; cl12078
196162013761	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
196162013762	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
196162013763	synthetase active site [active]
196162013764	NTP binding site [chemical binding]; other site
196162013765	metal binding site [ion binding]; metal-binding site
196162013766	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
196162013767	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
196162013768	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
196162013769	substrate binding site [chemical binding]; other site
196162013770	ATP binding site [chemical binding]; other site
196162013771	YibE/F-like protein; Region: YibE_F; pfam07907
196162013772	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
196162013773	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
196162013774	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
196162013775	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
196162013776	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
196162013777	tetrameric interface [polypeptide binding]; other site
196162013778	NAD binding site [chemical binding]; other site
196162013779	catalytic residues [active]
196162013780	hypothetical protein; Provisional; Region: PRK06062
196162013781	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
196162013782	inhibitor-cofactor binding pocket; inhibition site
196162013783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162013784	catalytic residue [active]
196162013785	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
196162013786	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
196162013787	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
196162013788	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
196162013789	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
196162013790	active site
196162013791	catalytic site [active]
196162013792	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
196162013793	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
196162013794	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
196162013795	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
196162013796	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
196162013797	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
196162013798	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162013799	dimer interface [polypeptide binding]; other site
196162013800	conserved gate region; other site
196162013801	putative PBP binding loops; other site
196162013802	ABC-ATPase subunit interface; other site
196162013803	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
196162013804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
196162013805	putative PBP binding loops; other site
196162013806	dimer interface [polypeptide binding]; other site
196162013807	ABC-ATPase subunit interface; other site
196162013808	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
196162013809	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
196162013810	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
196162013811	active site
196162013812	catalytic residues [active]
196162013813	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
196162013814	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162013815	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
196162013816	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
196162013817	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
196162013818	active site
196162013819	active site
196162013820	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162013821	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
196162013822	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
196162013823	active site
196162013824	nucleophile elbow; other site
196162013825	Uncharacterized conserved protein [Function unknown]; Region: COG3189
196162013826	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
196162013827	Predicted membrane protein [Function unknown]; Region: COG2246
196162013828	GtrA-like protein; Region: GtrA; pfam04138
196162013829	Transposase domain (DUF772); Region: DUF772; pfam05598
196162013830	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
196162013831	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
196162013832	Transposase; Region: DEDD_Tnp_IS110; pfam01548
196162013833	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
196162013834	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
196162013835	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
196162013836	transcription initiation factor E subunit alpha; Validated; Region: PRK06266
196162013837	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
196162013838	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
196162013839	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
196162013840	Walker A motif; other site
196162013841	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
196162013842	Hom_end-associated Hint; Region: Hom_end_hint; pfam05203
196162013843	replicative DNA helicase; Region: DnaB; TIGR00665
196162013844	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
196162013845	ATP binding site [chemical binding]; other site
196162013846	Walker B motif; other site
196162013847	DNA binding loops [nucleotide binding]
196162013848	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
196162013849	putative efflux protein, MATE family; Region: matE; TIGR00797
196162013850	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
196162013851	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
196162013852	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
196162013853	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
196162013854	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
196162013855	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
196162013856	dimer interface [polypeptide binding]; other site
196162013857	ssDNA binding site [nucleotide binding]; other site
196162013858	tetramer (dimer of dimers) interface [polypeptide binding]; other site
196162013859	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
196162013860	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
196162013861	Catalytic domain of Protein Kinases; Region: PKc; cd00180
196162013862	active site
196162013863	ATP binding site [chemical binding]; other site
196162013864	substrate binding site [chemical binding]; other site
196162013865	activation loop (A-loop); other site
196162013866	endonuclease IV; Provisional; Region: PRK01060
196162013867	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
196162013868	AP (apurinic/apyrimidinic) site pocket; other site
196162013869	DNA interaction; other site
196162013870	Metal-binding active site; metal-binding site
196162013871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
196162013872	TPR motif; other site
196162013873	binding surface
196162013874	CHAT domain; Region: CHAT; pfam12770
196162013875	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
196162013876	active site
196162013877	catalytic residues [active]
196162013878	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
196162013879	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162013880	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
196162013881	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
196162013882	Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168
196162013883	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
196162013884	catalytic residue [active]
196162013885	Predicted integral membrane protein [Function unknown]; Region: COG5650
196162013886	Transglycosylase; Region: Transgly; pfam00912
196162013887	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
196162013888	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
196162013889	Predicted transcriptional regulators [Transcription]; Region: COG1695
196162013890	Transcriptional regulator PadR-like family; Region: PadR; cl17335
196162013891	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
196162013892	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
196162013893	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
196162013894	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
196162013895	Domain of unknown function DUF87; Region: DUF87; pfam01935
196162013896	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
196162013897	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
196162013898	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
196162013899	active site
196162013900	NTP binding site [chemical binding]; other site
196162013901	metal binding triad [ion binding]; metal-binding site
196162013902	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
196162013903	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
196162013904	Zn2+ binding site [ion binding]; other site
196162013905	Mg2+ binding site [ion binding]; other site
196162013906	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
196162013907	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
196162013908	MviN-like protein; Region: MVIN; pfam03023
196162013909	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
196162013910	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
196162013911	active site
196162013912	ATP binding site [chemical binding]; other site
196162013913	RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643
196162013914	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
196162013915	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
196162013916	DNA binding residues [nucleotide binding]
196162013917	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
196162013918	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
196162013919	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
196162013920	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
196162013921	catalytic residues [active]
196162013922	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
196162013923	Coenzyme A binding pocket [chemical binding]; other site
196162013924	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
196162013925	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
196162013926	pyridoxal 5'-phosphate binding site [chemical binding]; other site
196162013927	homodimer interface [polypeptide binding]; other site
196162013928	catalytic residue [active]
196162013929	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
196162013930	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
196162013931	ATP-grasp domain; Region: ATP-grasp_4; cl17255
196162013932	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
196162013933	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
196162013934	putative acyl-acceptor binding pocket; other site
196162013935	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
196162013936	ParB-like nuclease domain; Region: ParBc; pfam02195
196162013937	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
196162013938	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162013939	P-loop; other site
196162013940	Magnesium ion binding site [ion binding]; other site
196162013941	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
196162013942	Magnesium ion binding site [ion binding]; other site
196162013943	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
196162013944	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
196162013945	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
196162013946	S-adenosylmethionine binding site [chemical binding]; other site
196162013947	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
196162013948	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
196162013949	G-X-X-G motif; other site
196162013950	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
196162013951	RxxxH motif; other site
196162013952	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
196162013953	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
196162013954	Haemolytic domain; Region: Haemolytic; pfam01809
196162013955	Ribonuclease P; Region: Ribonuclease_P; cl00457
196162013956	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399