-- dump date   	20140619_164914
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1127134000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
1127134000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134000003	Walker A motif; other site
1127134000004	ATP binding site [chemical binding]; other site
1127134000005	Walker B motif; other site
1127134000006	arginine finger; other site
1127134000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1127134000008	DnaA box-binding interface [nucleotide binding]; other site
1127134000009	DNA polymerase III subunit beta; Validated; Region: PRK07761
1127134000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1127134000011	putative DNA binding surface [nucleotide binding]; other site
1127134000012	dimer interface [polypeptide binding]; other site
1127134000013	beta-clamp/clamp loader binding surface; other site
1127134000014	beta-clamp/translesion DNA polymerase binding surface; other site
1127134000015	recombination protein F; Reviewed; Region: recF; PRK00064
1127134000016	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1127134000017	Walker A/P-loop; other site
1127134000018	ATP binding site [chemical binding]; other site
1127134000019	Q-loop/lid; other site
1127134000020	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134000021	ABC transporter signature motif; other site
1127134000022	Walker B; other site
1127134000023	D-loop; other site
1127134000024	H-loop/switch region; other site
1127134000025	hypothetical protein; Provisional; Region: PRK03195
1127134000026	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1127134000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134000029	ATP binding site [chemical binding]; other site
1127134000030	Mg2+ binding site [ion binding]; other site
1127134000031	G-X-G motif; other site
1127134000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1127134000033	anchoring element; other site
1127134000034	dimer interface [polypeptide binding]; other site
1127134000035	ATP binding site [chemical binding]; other site
1127134000036	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1127134000037	active site
1127134000038	putative metal-binding site [ion binding]; other site
1127134000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1127134000040	DNA gyrase subunit A; Validated; Region: PRK05560
1127134000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1127134000042	CAP-like domain; other site
1127134000043	active site
1127134000044	primary dimer interface [polypeptide binding]; other site
1127134000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1127134000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1127134000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1127134000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1127134000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1127134000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1127134000051	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
1127134000052	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
1127134000053	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1127134000054	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134000055	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134000056	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134000057	Walker A/P-loop; other site
1127134000058	ATP binding site [chemical binding]; other site
1127134000059	Q-loop/lid; other site
1127134000060	ABC transporter signature motif; other site
1127134000061	Walker B; other site
1127134000062	D-loop; other site
1127134000063	H-loop/switch region; other site
1127134000064	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134000065	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134000066	Rhomboid family; Region: Rhomboid; pfam01694
1127134000067	putative septation inhibitor protein; Reviewed; Region: PRK00159
1127134000068	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1127134000069	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1127134000070	glutamine binding [chemical binding]; other site
1127134000071	catalytic triad [active]
1127134000072	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1127134000073	RibD C-terminal domain; Region: RibD_C; cl17279
1127134000074	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1127134000075	catalytic motif [active]
1127134000076	Zn binding site [ion binding]; other site
1127134000077	FOG: CBS domain [General function prediction only]; Region: COG0517
1127134000078	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1127134000079	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134000080	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134000081	active site
1127134000082	ATP binding site [chemical binding]; other site
1127134000083	substrate binding site [chemical binding]; other site
1127134000084	activation loop (A-loop); other site
1127134000085	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1127134000086	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134000087	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134000088	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134000089	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134000090	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134000091	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134000092	active site
1127134000093	ATP binding site [chemical binding]; other site
1127134000094	substrate binding site [chemical binding]; other site
1127134000095	activation loop (A-loop); other site
1127134000096	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1127134000097	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1127134000098	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1127134000099	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1127134000100	active site
1127134000101	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134000102	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134000103	phosphopeptide binding site; other site
1127134000104	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
1127134000105	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134000106	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134000107	phosphopeptide binding site; other site
1127134000108	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134000109	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134000110	Berberine and berberine like; Region: BBE; pfam08031
1127134000111	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1127134000112	classical (c) SDRs; Region: SDR_c; cd05233
1127134000113	NAD(P) binding site [chemical binding]; other site
1127134000114	active site
1127134000115	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1127134000116	S-adenosylmethionine binding site [chemical binding]; other site
1127134000117	Integral membrane protein DUF95; Region: DUF95; pfam01944
1127134000118	Predicted membrane protein/domain [Function unknown]; Region: COG1714
1127134000119	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1127134000120	Protein of unknown function DUF58; Region: DUF58; pfam01882
1127134000121	MoxR-like ATPases [General function prediction only]; Region: COG0714
1127134000122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134000123	Walker A motif; other site
1127134000124	ATP binding site [chemical binding]; other site
1127134000125	Walker B motif; other site
1127134000126	arginine finger; other site
1127134000127	TetR family transcriptional regulator; Provisional; Region: PRK14996
1127134000128	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000129	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1127134000130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134000131	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134000132	dimerization interface [polypeptide binding]; other site
1127134000133	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1127134000134	cyclase homology domain; Region: CHD; cd07302
1127134000135	nucleotidyl binding site; other site
1127134000136	metal binding site [ion binding]; metal-binding site
1127134000137	dimer interface [polypeptide binding]; other site
1127134000138	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1127134000139	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1127134000140	active site
1127134000141	dimer interface [polypeptide binding]; other site
1127134000142	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1127134000143	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1127134000144	active site
1127134000145	FMN binding site [chemical binding]; other site
1127134000146	substrate binding site [chemical binding]; other site
1127134000147	3Fe-4S cluster binding site [ion binding]; other site
1127134000148	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1127134000149	domain interface; other site
1127134000150	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1127134000151	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134000152	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134000153	EspG family; Region: ESX-1_EspG; pfam14011
1127134000154	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1127134000155	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134000156	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1127134000157	oligomeric interface; other site
1127134000158	putative active site [active]
1127134000159	homodimer interface [polypeptide binding]; other site
1127134000160	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134000161	catalytic core [active]
1127134000162	Cutinase; Region: Cutinase; pfam01083
1127134000163	lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983
1127134000164	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1127134000165	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1127134000166	dimer interface [polypeptide binding]; other site
1127134000167	putative anticodon binding site; other site
1127134000168	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1127134000169	motif 1; other site
1127134000170	dimer interface [polypeptide binding]; other site
1127134000171	active site
1127134000172	motif 2; other site
1127134000173	motif 3; other site
1127134000174	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1127134000175	RNA binding surface [nucleotide binding]; other site
1127134000176	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
1127134000177	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1127134000178	hydrophobic ligand binding site; other site
1127134000179	CopC domain; Region: CopC; pfam04234
1127134000180	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1127134000181	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
1127134000182	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1127134000183	heat shock protein 90; Provisional; Region: PRK05218
1127134000184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134000185	ATP binding site [chemical binding]; other site
1127134000186	Mg2+ binding site [ion binding]; other site
1127134000187	G-X-G motif; other site
1127134000188	Cytochrome P450; Region: p450; cl12078
1127134000189	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1127134000190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134000191	NAD(P) binding site [chemical binding]; other site
1127134000192	active site
1127134000193	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134000194	NAD(P) binding site [chemical binding]; other site
1127134000195	active site
1127134000196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134000197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000198	Predicted membrane protein [Function unknown]; Region: COG2119
1127134000199	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1127134000200	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1127134000201	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1127134000202	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1127134000203	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1127134000204	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1127134000205	active site residue [active]
1127134000206	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
1127134000207	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1127134000208	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582
1127134000209	putative active site [active]
1127134000210	catalytic site [active]
1127134000211	putative metal binding site [ion binding]; other site
1127134000212	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1127134000213	Ferritin-like domain; Region: Ferritin; pfam00210
1127134000214	ferroxidase diiron center [ion binding]; other site
1127134000215	Ferritin-like domain; Region: Ferritin; pfam00210
1127134000216	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1127134000217	dinuclear metal binding motif [ion binding]; other site
1127134000218	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1127134000219	CAAX protease self-immunity; Region: Abi; pfam02517
1127134000220	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
1127134000221	prephenate dehydratase; Provisional; Region: PRK11898
1127134000222	Prephenate dehydratase; Region: PDT; pfam00800
1127134000223	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1127134000224	putative L-Phe binding site [chemical binding]; other site
1127134000225	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134000226	catalytic core [active]
1127134000227	EspG family; Region: ESX-1_EspG; pfam14011
1127134000228	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
1127134000229	Septum formation; Region: Septum_form; pfam13845
1127134000230	Septum formation; Region: Septum_form; pfam13845
1127134000231	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134000232	NAD(P) binding site [chemical binding]; other site
1127134000233	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1127134000234	catalytic residues [active]
1127134000235	seryl-tRNA synthetase; Provisional; Region: PRK05431
1127134000236	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1127134000237	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1127134000238	dimer interface [polypeptide binding]; other site
1127134000239	active site
1127134000240	motif 1; other site
1127134000241	motif 2; other site
1127134000242	motif 3; other site
1127134000243	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1127134000244	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1127134000245	metal binding site [ion binding]; metal-binding site
1127134000246	active site
1127134000247	I-site; other site
1127134000248	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1127134000249	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1127134000250	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1127134000251	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1127134000252	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1127134000253	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1127134000254	iron-sulfur cluster [ion binding]; other site
1127134000255	[2Fe-2S] cluster binding site [ion binding]; other site
1127134000256	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134000257	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1127134000258	putative acyl-acceptor binding pocket; other site
1127134000259	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1127134000260	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1127134000261	metal-binding site [ion binding]
1127134000262	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134000263	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1127134000264	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1127134000265	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1127134000266	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134000267	putative substrate translocation pore; other site
1127134000268	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1127134000269	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1127134000270	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134000271	DNA-binding site [nucleotide binding]; DNA binding site
1127134000272	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1127134000273	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134000274	Coenzyme A binding pocket [chemical binding]; other site
1127134000275	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1127134000276	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1127134000277	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1127134000278	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1127134000279	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1127134000280	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1127134000281	Walker A/P-loop; other site
1127134000282	ATP binding site [chemical binding]; other site
1127134000283	Q-loop/lid; other site
1127134000284	ABC transporter signature motif; other site
1127134000285	Walker B; other site
1127134000286	D-loop; other site
1127134000287	H-loop/switch region; other site
1127134000288	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1127134000289	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1127134000290	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1127134000291	Walker A/P-loop; other site
1127134000292	ATP binding site [chemical binding]; other site
1127134000293	Q-loop/lid; other site
1127134000294	ABC transporter signature motif; other site
1127134000295	Walker B; other site
1127134000296	D-loop; other site
1127134000297	H-loop/switch region; other site
1127134000298	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1127134000299	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1127134000300	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1127134000301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134000302	dimer interface [polypeptide binding]; other site
1127134000303	conserved gate region; other site
1127134000304	putative PBP binding loops; other site
1127134000305	ABC-ATPase subunit interface; other site
1127134000306	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1127134000307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134000308	dimer interface [polypeptide binding]; other site
1127134000309	conserved gate region; other site
1127134000310	putative PBP binding loops; other site
1127134000311	ABC-ATPase subunit interface; other site
1127134000312	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134000313	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1127134000314	active site
1127134000315	motif I; other site
1127134000316	motif II; other site
1127134000317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1127134000318	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1127134000319	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1127134000320	amidase catalytic site [active]
1127134000321	Zn binding residues [ion binding]; other site
1127134000322	substrate binding site [chemical binding]; other site
1127134000323	Stage II sporulation protein; Region: SpoIID; pfam08486
1127134000324	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134000325	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134000326	DNA binding residues [nucleotide binding]
1127134000327	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1127134000328	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1127134000329	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134000330	UDP-galactopyranose mutase; Region: GLF; pfam03275
1127134000331	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1127134000332	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134000333	active site
1127134000334	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
1127134000335	Predicted esterase [General function prediction only]; Region: COG0627
1127134000336	Predicted esterase [General function prediction only]; Region: COG0627
1127134000337	Putative esterase; Region: Esterase; pfam00756
1127134000338	Putative esterase; Region: Esterase; pfam00756
1127134000339	S-formylglutathione hydrolase; Region: PLN02442
1127134000340	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1127134000341	LGFP repeat; Region: LGFP; pfam08310
1127134000342	LGFP repeat; Region: LGFP; pfam08310
1127134000343	LGFP repeat; Region: LGFP; pfam08310
1127134000344	Protein of unknown function (DUF732); Region: DUF732; pfam05305
1127134000345	Cutinase; Region: Cutinase; pfam01083
1127134000346	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
1127134000347	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134000348	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769
1127134000349	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1127134000350	acyl-activating enzyme (AAE) consensus motif; other site
1127134000351	active site
1127134000352	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134000353	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1127134000354	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1127134000355	active site
1127134000356	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1127134000357	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1127134000358	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134000359	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1127134000360	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134000361	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134000362	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134000363	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
1127134000364	substrate binding site [chemical binding]; other site
1127134000365	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1127134000366	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1127134000367	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1127134000368	Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250
1127134000369	Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249
1127134000370	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1127134000371	classical (c) SDRs; Region: SDR_c; cd05233
1127134000372	NAD(P) binding site [chemical binding]; other site
1127134000373	active site
1127134000374	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134000375	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134000376	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1127134000377	Predicted membrane protein [Function unknown]; Region: COG2246
1127134000378	GtrA-like protein; Region: GtrA; pfam04138
1127134000379	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1127134000380	Domain of unknown function (DUF4282); Region: DUF4282; pfam14110
1127134000381	Helix-turn-helix domain; Region: HTH_31; pfam13560
1127134000382	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
1127134000383	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1127134000384	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1127134000385	substrate binding site; other site
1127134000386	tetramer interface; other site
1127134000387	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134000388	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134000389	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1127134000390	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1127134000391	NAD binding site [chemical binding]; other site
1127134000392	substrate binding site [chemical binding]; other site
1127134000393	homodimer interface [polypeptide binding]; other site
1127134000394	active site
1127134000395	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1127134000396	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
1127134000397	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1127134000398	Ligand binding site; other site
1127134000399	Putative Catalytic site; other site
1127134000400	DXD motif; other site
1127134000401	Predicted membrane protein [Function unknown]; Region: COG2246
1127134000402	GtrA-like protein; Region: GtrA; pfam04138
1127134000403	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1127134000404	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134000405	active site
1127134000406	short chain dehydrogenase; Provisional; Region: PRK08278
1127134000407	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134000408	NAD(P) binding site [chemical binding]; other site
1127134000409	active site
1127134000410	GTPase RsgA; Reviewed; Region: PRK01889
1127134000411	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1127134000412	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1127134000413	GTP/Mg2+ binding site [chemical binding]; other site
1127134000414	G4 box; other site
1127134000415	G5 box; other site
1127134000416	G1 box; other site
1127134000417	Switch I region; other site
1127134000418	G2 box; other site
1127134000419	G3 box; other site
1127134000420	Switch II region; other site
1127134000421	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1127134000422	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134000423	active site
1127134000424	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1127134000425	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1127134000426	Walker A/P-loop; other site
1127134000427	ATP binding site [chemical binding]; other site
1127134000428	Q-loop/lid; other site
1127134000429	ABC transporter signature motif; other site
1127134000430	Walker B; other site
1127134000431	D-loop; other site
1127134000432	H-loop/switch region; other site
1127134000433	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1127134000434	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1127134000435	Protein of unknown function (DUF2587); Region: DUF2587; pfam10759
1127134000436	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1127134000437	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134000438	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134000439	catalytic residue [active]
1127134000440	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1127134000441	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1127134000442	NAD(P) binding site [chemical binding]; other site
1127134000443	L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases.  It is thought...; Region: LMO_FMN; cd03332
1127134000444	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1127134000445	putative active site [active]
1127134000446	putative substrate binding site [chemical binding]; other site
1127134000447	putative FMN binding site [chemical binding]; other site
1127134000448	putative catalytic residues [active]
1127134000449	MarR family; Region: MarR_2; cl17246
1127134000450	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134000451	Predicted esterase [General function prediction only]; Region: COG0627
1127134000452	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1127134000453	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1127134000454	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134000455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134000456	homodimer interface [polypeptide binding]; other site
1127134000457	catalytic residue [active]
1127134000458	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1127134000459	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134000460	mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583
1127134000461	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134000462	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1127134000463	putative active site [active]
1127134000464	putative metal binding site [ion binding]; other site
1127134000465	imidazolonepropionase; Provisional; Region: PRK14085
1127134000466	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134000467	active site
1127134000468	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
1127134000469	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
1127134000470	Na binding site [ion binding]; other site
1127134000471	putative proline-specific permease; Provisional; Region: proY; PRK10580
1127134000472	Spore germination protein; Region: Spore_permease; cl17796
1127134000473	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1127134000474	active sites [active]
1127134000475	tetramer interface [polypeptide binding]; other site
1127134000476	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1127134000477	RNA binding site [nucleotide binding]; other site
1127134000478	Predicted transcriptional regulator [Transcription]; Region: COG2944
1127134000479	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134000480	active site
1127134000481	ATP binding site [chemical binding]; other site
1127134000482	substrate binding site [chemical binding]; other site
1127134000483	activation loop (A-loop); other site
1127134000484	urocanate hydratase; Provisional; Region: PRK05414
1127134000485	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1127134000486	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1127134000487	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134000488	DNA-binding site [nucleotide binding]; DNA binding site
1127134000489	UTRA domain; Region: UTRA; pfam07702
1127134000490	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1127134000491	putative active site [active]
1127134000492	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1127134000493	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1127134000494	cofactor binding site; other site
1127134000495	DNA binding site [nucleotide binding]
1127134000496	substrate interaction site [chemical binding]; other site
1127134000497	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1127134000498	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134000499	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134000500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134000501	Walker A/P-loop; other site
1127134000502	ATP binding site [chemical binding]; other site
1127134000503	Q-loop/lid; other site
1127134000504	ABC transporter signature motif; other site
1127134000505	Walker B; other site
1127134000506	D-loop; other site
1127134000507	H-loop/switch region; other site
1127134000508	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134000509	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134000510	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134000511	Walker A/P-loop; other site
1127134000512	ATP binding site [chemical binding]; other site
1127134000513	Q-loop/lid; other site
1127134000514	ABC transporter signature motif; other site
1127134000515	Walker B; other site
1127134000516	D-loop; other site
1127134000517	H-loop/switch region; other site
1127134000518	Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475
1127134000519	prephenate dehydrogenase; Validated; Region: PRK08507
1127134000520	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
1127134000521	putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941
1127134000522	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1127134000523	nucleoside/Zn binding site; other site
1127134000524	dimer interface [polypeptide binding]; other site
1127134000525	catalytic motif [active]
1127134000526	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134000527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134000528	Cytochrome P450; Region: p450; cl12078
1127134000529	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134000530	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134000531	MerR family regulatory protein; Region: MerR; pfam00376
1127134000532	DNA binding residues [nucleotide binding]
1127134000533	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1127134000534	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134000535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134000536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000537	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1127134000538	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134000539	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1127134000540	dimerization interface [polypeptide binding]; other site
1127134000541	substrate binding pocket [chemical binding]; other site
1127134000542	short chain dehydrogenase; Provisional; Region: PRK06180
1127134000543	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1127134000544	NADP binding site [chemical binding]; other site
1127134000545	active site
1127134000546	steroid binding site; other site
1127134000547	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1127134000548	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134000549	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000550	Predicted transcriptional regulator [Transcription]; Region: COG1959
1127134000551	Transcriptional regulator; Region: Rrf2; pfam02082
1127134000552	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134000553	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134000554	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134000555	Walker A/P-loop; other site
1127134000556	ATP binding site [chemical binding]; other site
1127134000557	Q-loop/lid; other site
1127134000558	ABC transporter signature motif; other site
1127134000559	Walker B; other site
1127134000560	D-loop; other site
1127134000561	H-loop/switch region; other site
1127134000562	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1127134000563	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134000564	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1127134000565	Walker A/P-loop; other site
1127134000566	ATP binding site [chemical binding]; other site
1127134000567	Q-loop/lid; other site
1127134000568	ABC transporter signature motif; other site
1127134000569	Walker B; other site
1127134000570	D-loop; other site
1127134000571	H-loop/switch region; other site
1127134000572	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1127134000573	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1127134000574	Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738
1127134000575	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1127134000576	RDD family; Region: RDD; pfam06271
1127134000577	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1127134000578	tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749
1127134000579	active site
1127134000580	HIGH motif; other site
1127134000581	nucleotide binding site [chemical binding]; other site
1127134000582	active site
1127134000583	KMSKS motif; other site
1127134000584	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1127134000585	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134000586	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1127134000587	heme bH binding site [chemical binding]; other site
1127134000588	intrachain domain interface; other site
1127134000589	heme bL binding site [chemical binding]; other site
1127134000590	interchain domain interface [polypeptide binding]; other site
1127134000591	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1127134000592	Qo binding site; other site
1127134000593	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134000594	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1127134000595	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134000596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134000597	NAD(P) binding site [chemical binding]; other site
1127134000598	active site
1127134000599	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1127134000600	active site
1127134000601	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1127134000602	Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451
1127134000603	Uncharacterized conserved protein [Function unknown]; Region: COG1656
1127134000604	Protein of unknown function DUF82; Region: DUF82; pfam01927
1127134000605	protein-export membrane protein SecD; Region: secD; TIGR01129
1127134000606	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1127134000607	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134000608	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134000609	catalytic residue [active]
1127134000610	hypothetical protein; Provisional; Region: PRK08317
1127134000611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134000612	S-adenosylmethionine binding site [chemical binding]; other site
1127134000613	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1127134000614	minor groove reading motif; other site
1127134000615	helix-hairpin-helix signature motif; other site
1127134000616	RibD C-terminal domain; Region: RibD_C; cl17279
1127134000617	N-acetylmannosamine kinase; Provisional; Region: PRK05082
1127134000618	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1127134000619	nucleotide binding site [chemical binding]; other site
1127134000620	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1127134000621	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134000622	DNA binding residues [nucleotide binding]
1127134000623	HTH-like domain; Region: HTH_21; pfam13276
1127134000624	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1127134000625	Integrase core domain; Region: rve; pfam00665
1127134000626	Integrase core domain; Region: rve_3; pfam13683
1127134000627	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1127134000628	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1127134000629	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1127134000630	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1127134000631	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134000632	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000633	WHG domain; Region: WHG; pfam13305
1127134000634	MMPL family; Region: MMPL; pfam03176
1127134000635	MMPL family; Region: MMPL; pfam03176
1127134000636	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
1127134000637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134000638	Walker A motif; other site
1127134000639	ATP binding site [chemical binding]; other site
1127134000640	Walker B motif; other site
1127134000641	arginine finger; other site
1127134000642	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1127134000643	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1127134000644	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134000645	dimer interface [polypeptide binding]; other site
1127134000646	active site
1127134000647	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
1127134000648	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134000649	substrate binding site [chemical binding]; other site
1127134000650	oxyanion hole (OAH) forming residues; other site
1127134000651	trimer interface [polypeptide binding]; other site
1127134000652	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1127134000653	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1127134000654	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134000655	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134000656	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134000657	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134000658	active site
1127134000659	ATP binding site [chemical binding]; other site
1127134000660	substrate binding site [chemical binding]; other site
1127134000661	activation loop (A-loop); other site
1127134000662	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1127134000663	Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353
1127134000664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134000665	S-adenosylmethionine binding site [chemical binding]; other site
1127134000666	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134000667	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134000668	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
1127134000669	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1127134000670	active site
1127134000671	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1127134000672	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134000673	DNA binding residues [nucleotide binding]
1127134000674	drug binding residues [chemical binding]; other site
1127134000675	dimer interface [polypeptide binding]; other site
1127134000676	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1127134000677	hypothetical protein; Validated; Region: PRK00153
1127134000678	recombination protein RecR; Reviewed; Region: recR; PRK00076
1127134000679	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1127134000680	RecR protein; Region: RecR; pfam02132
1127134000681	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1127134000682	putative active site [active]
1127134000683	putative metal-binding site [ion binding]; other site
1127134000684	tetramer interface [polypeptide binding]; other site
1127134000685	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1127134000686	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134000687	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
1127134000688	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1127134000689	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1127134000690	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1127134000691	catalytic triad [active]
1127134000692	EamA-like transporter family; Region: EamA; pfam00892
1127134000693	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1127134000694	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134000695	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134000696	putative DNA binding site [nucleotide binding]; other site
1127134000697	dimerization interface [polypeptide binding]; other site
1127134000698	putative Zn2+ binding site [ion binding]; other site
1127134000699	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134000700	dimerization interface [polypeptide binding]; other site
1127134000701	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1127134000702	2-isopropylmalate synthase; Validated; Region: PRK03739
1127134000703	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1127134000704	active site
1127134000705	catalytic residues [active]
1127134000706	metal binding site [ion binding]; metal-binding site
1127134000707	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1127134000708	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1127134000709	hypothetical protein; Provisional; Region: PRK10621
1127134000710	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1127134000711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134000712	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1127134000713	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1127134000714	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134000715	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1127134000716	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1127134000717	putative hydrophobic ligand binding site [chemical binding]; other site
1127134000718	Domain of unknown function (DUF1918); Region: DUF1918; pfam08940
1127134000719	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000720	RibD C-terminal domain; Region: RibD_C; cl17279
1127134000721	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134000722	RibD C-terminal domain; Region: RibD_C; cl17279
1127134000723	aspartate kinase; Reviewed; Region: PRK06635
1127134000724	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1127134000725	putative nucleotide binding site [chemical binding]; other site
1127134000726	putative catalytic residues [active]
1127134000727	putative Mg ion binding site [ion binding]; other site
1127134000728	putative aspartate binding site [chemical binding]; other site
1127134000729	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1127134000730	putative allosteric regulatory site; other site
1127134000731	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1127134000732	putative allosteric regulatory residue; other site
1127134000733	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1127134000734	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1127134000735	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134000736	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134000737	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1127134000738	metal binding site 2 [ion binding]; metal-binding site
1127134000739	putative DNA binding helix; other site
1127134000740	metal binding site 1 [ion binding]; metal-binding site
1127134000741	dimer interface [polypeptide binding]; other site
1127134000742	structural Zn2+ binding site [ion binding]; other site
1127134000743	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1127134000744	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1127134000745	tetramer interface [polypeptide binding]; other site
1127134000746	heme binding pocket [chemical binding]; other site
1127134000747	NADPH binding site [chemical binding]; other site
1127134000748	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
1127134000749	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319
1127134000750	gating phenylalanine in ion channel; other site
1127134000751	hypothetical protein; Provisional; Region: PRK07588
1127134000752	hypothetical protein; Provisional; Region: PRK07236
1127134000753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134000754	allophanate hydrolase; Provisional; Region: PRK08186
1127134000755	Amidase; Region: Amidase; cl11426
1127134000756	urea carboxylase; Region: urea_carbox; TIGR02712
1127134000757	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134000758	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134000759	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1127134000760	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1127134000761	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1127134000762	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134000763	carboxyltransferase (CT) interaction site; other site
1127134000764	biotinylation site [posttranslational modification]; other site
1127134000765	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1127134000766	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134000767	DNA-binding site [nucleotide binding]; DNA binding site
1127134000768	FCD domain; Region: FCD; pfam07729
1127134000769	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134000770	Cytochrome P450; Region: p450; cl12078
1127134000771	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134000772	Retinoic acid induced 16-like protein; Region: RAI16-like; pfam10257
1127134000773	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1127134000774	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1127134000775	putative active site [active]
1127134000776	putative metal binding site [ion binding]; other site
1127134000777	Yqey-like protein; Region: YqeY; pfam09424
1127134000778	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1127134000779	Transglycosylase; Region: Transgly; pfam00912
1127134000780	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1127134000781	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134000782	Transcription factor WhiB; Region: Whib; pfam02467
1127134000783	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1127134000784	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1127134000785	P loop; other site
1127134000786	Nucleotide binding site [chemical binding]; other site
1127134000787	DTAP/Switch II; other site
1127134000788	Switch I; other site
1127134000789	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1127134000790	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1127134000791	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1127134000792	P loop; other site
1127134000793	Nucleotide binding site [chemical binding]; other site
1127134000794	DTAP/Switch II; other site
1127134000795	Switch I; other site
1127134000796	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1127134000797	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1127134000798	homotrimer interaction site [polypeptide binding]; other site
1127134000799	putative active site [active]
1127134000800	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134000801	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1127134000802	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1127134000803	ligand binding site [chemical binding]; other site
1127134000804	flexible hinge region; other site
1127134000805	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1127134000806	putative switch regulator; other site
1127134000807	non-specific DNA interactions [nucleotide binding]; other site
1127134000808	DNA binding site [nucleotide binding]
1127134000809	sequence specific DNA binding site [nucleotide binding]; other site
1127134000810	putative cAMP binding site [chemical binding]; other site
1127134000811	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1127134000812	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1127134000813	minor groove reading motif; other site
1127134000814	helix-hairpin-helix signature motif; other site
1127134000815	substrate binding pocket [chemical binding]; other site
1127134000816	active site
1127134000817	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1127134000818	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1127134000819	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1127134000820	catalytic residues [active]
1127134000821	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1127134000822	putative active site [active]
1127134000823	putative CoA binding site [chemical binding]; other site
1127134000824	nudix motif; other site
1127134000825	metal binding site [ion binding]; metal-binding site
1127134000826	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1127134000827	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134000828	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134000829	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1127134000830	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
1127134000831	acetyl-CoA synthetase; Provisional; Region: PRK00174
1127134000832	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1127134000833	active site
1127134000834	CoA binding site [chemical binding]; other site
1127134000835	acyl-activating enzyme (AAE) consensus motif; other site
1127134000836	AMP binding site [chemical binding]; other site
1127134000837	acetate binding site [chemical binding]; other site
1127134000838	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1127134000839	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1127134000840	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1127134000841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134000842	dimer interface [polypeptide binding]; other site
1127134000843	conserved gate region; other site
1127134000844	putative PBP binding loops; other site
1127134000845	ABC-ATPase subunit interface; other site
1127134000846	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1127134000847	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134000848	dimer interface [polypeptide binding]; other site
1127134000849	conserved gate region; other site
1127134000850	putative PBP binding loops; other site
1127134000851	ABC-ATPase subunit interface; other site
1127134000852	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1127134000853	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1127134000854	Walker A/P-loop; other site
1127134000855	ATP binding site [chemical binding]; other site
1127134000856	Q-loop/lid; other site
1127134000857	ABC transporter signature motif; other site
1127134000858	Walker B; other site
1127134000859	D-loop; other site
1127134000860	H-loop/switch region; other site
1127134000861	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1127134000862	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1127134000863	Walker A/P-loop; other site
1127134000864	ATP binding site [chemical binding]; other site
1127134000865	Q-loop/lid; other site
1127134000866	ABC transporter signature motif; other site
1127134000867	Walker B; other site
1127134000868	D-loop; other site
1127134000869	H-loop/switch region; other site
1127134000870	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1127134000871	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1127134000872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134000873	motif II; other site
1127134000874	helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815
1127134000875	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1127134000876	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1127134000877	Helix-turn-helix domain; Region: HTH_17; pfam12728
1127134000878	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1127134000879	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
1127134000880	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134000881	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134000882	sequence-specific DNA binding site [nucleotide binding]; other site
1127134000883	salt bridge; other site
1127134000884	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134000885	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1127134000886	catalytic residues [active]
1127134000887	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1127134000888	Recombinase; Region: Recombinase; pfam07508
1127134000889	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1127134000890	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1127134000891	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1127134000892	hexamer interface [polypeptide binding]; other site
1127134000893	Walker B motif; other site
1127134000894	helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816
1127134000895	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
1127134000896	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134000897	ATP binding site [chemical binding]; other site
1127134000898	putative Mg++ binding site [ion binding]; other site
1127134000899	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134000900	nucleotide binding region [chemical binding]; other site
1127134000901	ATP-binding site [chemical binding]; other site
1127134000902	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1127134000903	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1127134000904	DNA-binding site [nucleotide binding]; DNA binding site
1127134000905	RNA-binding motif; other site
1127134000906	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1127134000907	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1127134000908	active site
1127134000909	interdomain interaction site; other site
1127134000910	putative metal-binding site [ion binding]; other site
1127134000911	nucleotide binding site [chemical binding]; other site
1127134000912	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1127134000913	domain I; other site
1127134000914	phosphate binding site [ion binding]; other site
1127134000915	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1127134000916	domain II; other site
1127134000917	domain III; other site
1127134000918	nucleotide binding site [chemical binding]; other site
1127134000919	DNA binding groove [nucleotide binding]
1127134000920	catalytic site [active]
1127134000921	domain IV; other site
1127134000922	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1127134000923	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1127134000924	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1127134000925	DNA polymerase III subunit delta'; Validated; Region: PRK07940
1127134000926	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1127134000927	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134000928	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1127134000929	active site
1127134000930	DNA binding site [nucleotide binding]
1127134000931	Int/Topo IB signature motif; other site
1127134000932	Helix-turn-helix domain; Region: HTH_17; cl17695
1127134000933	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1127134000934	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
1127134000935	polymerase nucleotide-binding site; other site
1127134000936	DNA-binding residues [nucleotide binding]; DNA binding site
1127134000937	nucleotide binding site [chemical binding]; other site
1127134000938	primase nucleotide-binding site [nucleotide binding]; other site
1127134000939	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
1127134000940	Helix-turn-helix domain; Region: HTH_17; pfam12728
1127134000941	Helix-turn-helix domain; Region: HTH_31; pfam13560
1127134000942	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1127134000943	Ligand Binding Site [chemical binding]; other site
1127134000944	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1127134000945	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134000946	putative metal binding site [ion binding]; other site
1127134000947	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134000948	dimerization interface [polypeptide binding]; other site
1127134000949	putative DNA binding site [nucleotide binding]; other site
1127134000950	putative Zn2+ binding site [ion binding]; other site
1127134000951	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134000952	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
1127134000953	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1127134000954	Peptidase family M1; Region: Peptidase_M1; pfam01433
1127134000955	Zn binding site [ion binding]; other site
1127134000956	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134000957	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134000958	acyl-activating enzyme (AAE) consensus motif; other site
1127134000959	AMP binding site [chemical binding]; other site
1127134000960	active site
1127134000961	CoA binding site [chemical binding]; other site
1127134000962	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134000963	non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353
1127134000964	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1127134000965	putative trimer interface [polypeptide binding]; other site
1127134000966	putative CoA binding site [chemical binding]; other site
1127134000967	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1127134000968	putative trimer interface [polypeptide binding]; other site
1127134000969	putative CoA binding site [chemical binding]; other site
1127134000970	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1127134000971	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134000972	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134000973	catalytic residue [active]
1127134000974	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1127134000975	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1127134000976	putative deacylase active site [active]
1127134000977	enoyl-CoA hydratase; Provisional; Region: PRK06142
1127134000978	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134000979	substrate binding site [chemical binding]; other site
1127134000980	oxyanion hole (OAH) forming residues; other site
1127134000981	trimer interface [polypeptide binding]; other site
1127134000982	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1127134000983	dimer interface [polypeptide binding]; other site
1127134000984	substrate binding site [chemical binding]; other site
1127134000985	metal binding sites [ion binding]; metal-binding site
1127134000986	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1127134000987	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1127134000988	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
1127134000989	putative hydrolase; Region: TIGR03624
1127134000990	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1127134000991	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1127134000992	Ligand Binding Site [chemical binding]; other site
1127134000993	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134000994	active site
1127134000995	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134000996	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134000997	active site
1127134000998	ATP binding site [chemical binding]; other site
1127134000999	substrate binding site [chemical binding]; other site
1127134001000	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134001001	substrate binding site [chemical binding]; other site
1127134001002	activation loop (A-loop); other site
1127134001003	activation loop (A-loop); other site
1127134001004	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1127134001005	Amidase; Region: Amidase; cl11426
1127134001006	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134001007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134001008	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1127134001009	dimerization interface [polypeptide binding]; other site
1127134001010	substrate binding pocket [chemical binding]; other site
1127134001011	short chain dehydrogenase; Provisional; Region: PRK07825
1127134001012	classical (c) SDRs; Region: SDR_c; cd05233
1127134001013	NAD(P) binding site [chemical binding]; other site
1127134001014	active site
1127134001015	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134001016	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
1127134001017	NAD(P) binding site [chemical binding]; other site
1127134001018	catalytic residues [active]
1127134001019	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1127134001020	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134001021	Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349
1127134001022	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
1127134001023	FtsH Extracellular; Region: FtsH_ext; pfam06480
1127134001024	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1127134001025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134001026	Walker A motif; other site
1127134001027	ATP binding site [chemical binding]; other site
1127134001028	Walker B motif; other site
1127134001029	arginine finger; other site
1127134001030	Peptidase family M41; Region: Peptidase_M41; pfam01434
1127134001031	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1127134001032	homodecamer interface [polypeptide binding]; other site
1127134001033	GTP cyclohydrolase I; Provisional; Region: PLN03044
1127134001034	active site
1127134001035	putative catalytic site residues [active]
1127134001036	zinc binding site [ion binding]; other site
1127134001037	GTP-CH-I/GFRP interaction surface; other site
1127134001038	dihydropteroate synthase; Region: DHPS; TIGR01496
1127134001039	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1127134001040	substrate binding pocket [chemical binding]; other site
1127134001041	dimer interface [polypeptide binding]; other site
1127134001042	inhibitor binding site; inhibition site
1127134001043	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1127134001044	homooctamer interface [polypeptide binding]; other site
1127134001045	active site
1127134001046	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1127134001047	catalytic center binding site [active]
1127134001048	ATP binding site [chemical binding]; other site
1127134001049	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
1127134001050	Rossmann-like domain; Region: Rossmann-like; pfam10727
1127134001051	Uncharacterized conserved protein [Function unknown]; Region: COG5495
1127134001052	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
1127134001053	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1127134001054	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1127134001055	active site
1127134001056	ATP-binding site [chemical binding]; other site
1127134001057	pantoate-binding site; other site
1127134001058	HXXH motif; other site
1127134001059	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1127134001060	tetramerization interface [polypeptide binding]; other site
1127134001061	active site
1127134001062	pantothenate kinase; Reviewed; Region: PRK13318
1127134001063	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1127134001064	Rhodanese Homology Domain; Region: RHOD; smart00450
1127134001065	active site residue [active]
1127134001066	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1127134001067	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1127134001068	dimer interface [polypeptide binding]; other site
1127134001069	putative anticodon binding site; other site
1127134001070	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1127134001071	motif 1; other site
1127134001072	dimer interface [polypeptide binding]; other site
1127134001073	active site
1127134001074	motif 2; other site
1127134001075	motif 3; other site
1127134001076	Lsr2; Region: Lsr2; pfam11774
1127134001077	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134001078	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134001079	phosphopeptide binding site; other site
1127134001080	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134001081	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134001082	DNA binding residues [nucleotide binding]
1127134001083	dimerization interface [polypeptide binding]; other site
1127134001084	Domain of unknown function (DUF1772); Region: DUF1772; pfam08592
1127134001085	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1127134001086	Lipase (class 2); Region: Lipase_2; pfam01674
1127134001087	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1127134001088	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134001089	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134001090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134001091	Walker A motif; other site
1127134001092	ATP binding site [chemical binding]; other site
1127134001093	Walker B motif; other site
1127134001094	arginine finger; other site
1127134001095	UvrB/uvrC motif; Region: UVR; pfam02151
1127134001096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134001097	Walker A motif; other site
1127134001098	ATP binding site [chemical binding]; other site
1127134001099	Walker B motif; other site
1127134001100	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1127134001101	Domain of unknown function (DUF1877); Region: DUF1877; pfam08974
1127134001102	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134001103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134001104	active site
1127134001105	phosphorylation site [posttranslational modification]
1127134001106	intermolecular recognition site; other site
1127134001107	dimerization interface [polypeptide binding]; other site
1127134001108	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134001109	DNA binding residues [nucleotide binding]
1127134001110	dimerization interface [polypeptide binding]; other site
1127134001111	TraX protein; Region: TraX; cl05434
1127134001112	Histidine kinase; Region: HisKA_3; pfam07730
1127134001113	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134001114	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134001115	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1127134001116	Walker A/P-loop; other site
1127134001117	ATP binding site [chemical binding]; other site
1127134001118	Q-loop/lid; other site
1127134001119	ABC transporter signature motif; other site
1127134001120	Walker B; other site
1127134001121	D-loop; other site
1127134001122	H-loop/switch region; other site
1127134001123	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1127134001124	putative hydrophobic ligand binding site [chemical binding]; other site
1127134001125	OsmC-like protein; Region: OsmC; cl00767
1127134001126	Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266
1127134001127	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1127134001128	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134001129	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1127134001130	catalytic site [active]
1127134001131	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1127134001132	endonuclease III; Region: ENDO3c; smart00478
1127134001133	minor groove reading motif; other site
1127134001134	helix-hairpin-helix signature motif; other site
1127134001135	substrate binding pocket [chemical binding]; other site
1127134001136	active site
1127134001137	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1127134001138	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1127134001139	active site clefts [active]
1127134001140	zinc binding site [ion binding]; other site
1127134001141	dimer interface [polypeptide binding]; other site
1127134001142	Protein of unknown function (DUF4232); Region: DUF4232; pfam14016
1127134001143	DNA repair protein RadA; Provisional; Region: PRK11823
1127134001144	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1127134001145	Walker A motif; other site
1127134001146	ATP binding site [chemical binding]; other site
1127134001147	Walker B motif; other site
1127134001148	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1127134001149	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1127134001150	substrate binding site; other site
1127134001151	dimer interface; other site
1127134001152	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1127134001153	homotrimer interaction site [polypeptide binding]; other site
1127134001154	zinc binding site [ion binding]; other site
1127134001155	CDP-binding sites; other site
1127134001156	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1127134001157	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134001158	active site
1127134001159	HIGH motif; other site
1127134001160	nucleotide binding site [chemical binding]; other site
1127134001161	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1127134001162	KMSKS motif; other site
1127134001163	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1127134001164	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1127134001165	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1127134001166	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1127134001167	enoyl-CoA hydratase; Provisional; Region: PRK08260
1127134001168	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134001169	substrate binding site [chemical binding]; other site
1127134001170	oxyanion hole (OAH) forming residues; other site
1127134001171	trimer interface [polypeptide binding]; other site
1127134001172	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001173	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1127134001174	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1127134001175	active site
1127134001176	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134001177	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134001178	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
1127134001179	dimer interface [polypeptide binding]; other site
1127134001180	FMN binding site [chemical binding]; other site
1127134001181	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1127134001182	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1127134001183	putative PBP binding regions; other site
1127134001184	ABC-ATPase subunit  interface; other site
1127134001185	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1127134001186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134001187	Walker A/P-loop; other site
1127134001188	ATP binding site [chemical binding]; other site
1127134001189	Q-loop/lid; other site
1127134001190	ABC transporter signature motif; other site
1127134001191	Walker B; other site
1127134001192	D-loop; other site
1127134001193	H-loop/switch region; other site
1127134001194	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1127134001195	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1127134001196	intersubunit interface [polypeptide binding]; other site
1127134001197	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
1127134001198	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
1127134001199	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1127134001200	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1127134001201	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134001202	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134001203	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1127134001204	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001205	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001206	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001207	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001208	active site
1127134001209	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001210	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001211	active site
1127134001212	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001213	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001214	active site
1127134001215	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134001216	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1127134001217	DUF35 OB-fold domain; Region: DUF35; pfam01796
1127134001218	SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  The alpha- and...; Region: SAV4209; cd03455
1127134001219	putative active site [active]
1127134001220	putative catalytic site [active]
1127134001221	lipid-transfer protein; Provisional; Region: PRK07855
1127134001222	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134001223	active site
1127134001224	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1127134001225	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134001226	Predicted ATPase [General function prediction only]; Region: COG1485
1127134001227	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1127134001228	MoxR-like ATPases [General function prediction only]; Region: COG0714
1127134001229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134001230	Walker A motif; other site
1127134001231	ATP binding site [chemical binding]; other site
1127134001232	Walker B motif; other site
1127134001233	arginine finger; other site
1127134001234	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1127134001235	Protein of unknown function DUF58; Region: DUF58; pfam01882
1127134001236	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1127134001237	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1127134001238	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1127134001239	putative active site [active]
1127134001240	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1127134001241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1127134001242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134001243	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134001244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134001245	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1127134001246	EspG family; Region: ESX-1_EspG; pfam14011
1127134001247	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134001248	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134001249	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134001250	non-specific DNA binding site [nucleotide binding]; other site
1127134001251	salt bridge; other site
1127134001252	sequence-specific DNA binding site [nucleotide binding]; other site
1127134001253	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
1127134001254	enoyl-CoA hydratase; Region: PLN02864
1127134001255	Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452
1127134001256	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
1127134001257	dimer interaction site [polypeptide binding]; other site
1127134001258	substrate-binding tunnel; other site
1127134001259	active site
1127134001260	catalytic site [active]
1127134001261	substrate binding site [chemical binding]; other site
1127134001262	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
1127134001263	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134001264	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1127134001265	2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971
1127134001266	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1127134001267	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1127134001268	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1127134001269	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1127134001270	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1127134001271	active site
1127134001272	catalytic residues [active]
1127134001273	metal binding site [ion binding]; metal-binding site
1127134001274	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1127134001275	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1127134001276	putative active site [active]
1127134001277	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
1127134001278	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
1127134001279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1127134001280	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1127134001281	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1127134001282	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1127134001283	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1127134001284	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1127134001285	active site
1127134001286	Fe binding site [ion binding]; other site
1127134001287	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1127134001288	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1127134001289	catalytic site [active]
1127134001290	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001291	Naphthocyclinone hydroxylase; Region: NcnH; cd01159
1127134001292	Flavin binding site [chemical binding]; other site
1127134001293	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1127134001294	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1127134001295	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134001296	hydrophobic ligand binding site; other site
1127134001297	Domain of unknown function (DUF427); Region: DUF427; cl00998
1127134001298	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1127134001299	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134001300	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134001301	putative substrate translocation pore; other site
1127134001302	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134001303	MarR family; Region: MarR; pfam01047
1127134001304	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1127134001305	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001306	active site
1127134001307	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001308	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001309	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001310	active site
1127134001311	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001312	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001313	active site
1127134001314	enoyl-CoA hydratase; Provisional; Region: PRK08290
1127134001315	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134001316	substrate binding site [chemical binding]; other site
1127134001317	oxyanion hole (OAH) forming residues; other site
1127134001318	trimer interface [polypeptide binding]; other site
1127134001319	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
1127134001320	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001321	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001322	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1127134001323	acyl-activating enzyme (AAE) consensus motif; other site
1127134001324	acyl-activating enzyme (AAE) consensus motif; other site
1127134001325	putative AMP binding site [chemical binding]; other site
1127134001326	putative active site [active]
1127134001327	putative CoA binding site [chemical binding]; other site
1127134001328	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1127134001329	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134001330	active site
1127134001331	short chain dehydrogenase; Provisional; Region: PRK07831
1127134001332	classical (c) SDRs; Region: SDR_c; cd05233
1127134001333	NAD(P) binding site [chemical binding]; other site
1127134001334	active site
1127134001335	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134001336	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134001337	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1127134001338	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134001339	dimer interface [polypeptide binding]; other site
1127134001340	active site
1127134001341	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1127134001342	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1127134001343	Nitronate monooxygenase; Region: NMO; pfam03060
1127134001344	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134001345	FMN binding site [chemical binding]; other site
1127134001346	substrate binding site [chemical binding]; other site
1127134001347	putative catalytic residue [active]
1127134001348	Coenzyme A transferase; Region: CoA_trans; cl17247
1127134001349	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1127134001350	enoyl-CoA hydratase; Provisional; Region: PRK06495
1127134001351	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134001352	substrate binding site [chemical binding]; other site
1127134001353	oxyanion hole (OAH) forming residues; other site
1127134001354	trimer interface [polypeptide binding]; other site
1127134001355	classical (c) SDRs; Region: SDR_c; cd05233
1127134001356	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1127134001357	NAD(P) binding site [chemical binding]; other site
1127134001358	active site
1127134001359	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
1127134001360	NAD binding site [chemical binding]; other site
1127134001361	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
1127134001362	homodimer interface [polypeptide binding]; other site
1127134001363	active site
1127134001364	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1127134001365	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134001366	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134001367	sequence-specific DNA binding site [nucleotide binding]; other site
1127134001368	salt bridge; other site
1127134001369	acetyl-CoA acetyltransferase; Provisional; Region: PRK07850
1127134001370	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134001371	dimer interface [polypeptide binding]; other site
1127134001372	active site
1127134001373	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134001374	Cytochrome P450; Region: p450; cl12078
1127134001375	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134001376	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134001377	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1127134001378	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
1127134001379	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134001380	active site
1127134001381	lipid-transfer protein; Provisional; Region: PRK07937
1127134001382	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134001383	active site
1127134001384	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1127134001385	DUF35 OB-fold domain; Region: DUF35; pfam01796
1127134001386	Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545
1127134001387	DUF35 OB-fold domain; Region: DUF35; pfam01796
1127134001388	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1127134001389	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1127134001390	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001391	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001392	active site
1127134001393	CoA binding site [chemical binding]; other site
1127134001394	AMP binding site [chemical binding]; other site
1127134001395	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1127134001396	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134001397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134001398	DNA binding residues [nucleotide binding]
1127134001399	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134001400	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1127134001401	enoyl-CoA hydratase; Provisional; Region: PRK07799
1127134001402	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134001403	substrate binding site [chemical binding]; other site
1127134001404	oxyanion hole (OAH) forming residues; other site
1127134001405	trimer interface [polypeptide binding]; other site
1127134001406	acyl-CoA synthetase; Validated; Region: PRK07798
1127134001407	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001408	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924
1127134001409	acyl-activating enzyme (AAE) consensus motif; other site
1127134001410	acyl-activating enzyme (AAE) consensus motif; other site
1127134001411	putative AMP binding site [chemical binding]; other site
1127134001412	putative active site [active]
1127134001413	putative CoA binding site [chemical binding]; other site
1127134001414	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001415	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1127134001416	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1127134001417	active site
1127134001418	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134001419	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1127134001420	FAD binding site [chemical binding]; other site
1127134001421	substrate binding site [chemical binding]; other site
1127134001422	catalytic base [active]
1127134001423	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792
1127134001424	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134001425	NAD(P) binding site [chemical binding]; other site
1127134001426	active site
1127134001427	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134001428	Permease; Region: Permease; pfam02405
1127134001429	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134001430	Permease; Region: Permease; pfam02405
1127134001431	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134001432	mce related protein; Region: MCE; pfam02470
1127134001433	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134001434	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134001435	mce related protein; Region: MCE; pfam02470
1127134001436	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134001437	mce related protein; Region: MCE; pfam02470
1127134001438	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134001439	mce related protein; Region: MCE; pfam02470
1127134001440	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134001441	mce related protein; Region: MCE; pfam02470
1127134001442	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134001443	mce related protein; Region: MCE; pfam02470
1127134001444	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1127134001445	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
1127134001446	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1127134001447	MULE transposase domain; Region: MULE; pfam10551
1127134001448	MbtH-like protein; Region: MbtH; pfam03621
1127134001449	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134001450	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1127134001451	catalytic site [active]
1127134001452	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1127134001453	Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380
1127134001454	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1127134001455	active site
1127134001456	homotetramer interface [polypeptide binding]; other site
1127134001457	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134001458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134001459	active site
1127134001460	phosphorylation site [posttranslational modification]
1127134001461	intermolecular recognition site; other site
1127134001462	dimerization interface [polypeptide binding]; other site
1127134001463	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134001464	DNA binding site [nucleotide binding]
1127134001465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134001466	dimer interface [polypeptide binding]; other site
1127134001467	phosphorylation site [posttranslational modification]
1127134001468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134001469	ATP binding site [chemical binding]; other site
1127134001470	G-X-G motif; other site
1127134001471	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1127134001472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134001473	S-adenosylmethionine binding site [chemical binding]; other site
1127134001474	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1127134001475	nucleotide binding site/active site [active]
1127134001476	HIT family signature motif; other site
1127134001477	catalytic residue [active]
1127134001478	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1127134001479	pentamer interface [polypeptide binding]; other site
1127134001480	dodecaamer interface [polypeptide binding]; other site
1127134001481	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1127134001482	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1127134001483	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1127134001484	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1127134001485	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1127134001486	Peptidase family M23; Region: Peptidase_M23; pfam01551
1127134001487	aspartate aminotransferase; Provisional; Region: PRK05764
1127134001488	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134001489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134001490	homodimer interface [polypeptide binding]; other site
1127134001491	catalytic residue [active]
1127134001492	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1127134001493	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1127134001494	tetramer interface [polypeptide binding]; other site
1127134001495	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1127134001496	HIT family signature motif; other site
1127134001497	catalytic residue [active]
1127134001498	Putative esterase; Region: Esterase; pfam00756
1127134001499	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1127134001500	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134001501	Predicted deacetylase [General function prediction only]; Region: COG3233
1127134001502	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
1127134001503	putative active site [active]
1127134001504	putative Zn binding site [ion binding]; other site
1127134001505	hypothetical protein; Provisional; Region: PRK07907
1127134001506	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
1127134001507	active site
1127134001508	metal binding site [ion binding]; metal-binding site
1127134001509	dimer interface [polypeptide binding]; other site
1127134001510	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1127134001511	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1127134001512	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1127134001513	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1127134001514	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1127134001515	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1127134001516	putative active site [active]
1127134001517	catalytic triad [active]
1127134001518	M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658
1127134001519	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
1127134001520	active site
1127134001521	metal binding site [ion binding]; metal-binding site
1127134001522	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
1127134001523	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1127134001524	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1127134001525	dimerization interface [polypeptide binding]; other site
1127134001526	ATP binding site [chemical binding]; other site
1127134001527	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1127134001528	dimerization interface [polypeptide binding]; other site
1127134001529	ATP binding site [chemical binding]; other site
1127134001530	yiaA/B two helix domain; Region: YiaAB; cl01759
1127134001531	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1127134001532	CAAX protease self-immunity; Region: Abi; pfam02517
1127134001533	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1127134001534	Protein of unknown function (DUF3533); Region: DUF3533; pfam12051
1127134001535	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1127134001536	amidophosphoribosyltransferase; Provisional; Region: PRK07847
1127134001537	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1127134001538	active site
1127134001539	tetramer interface [polypeptide binding]; other site
1127134001540	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134001541	active site
1127134001542	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1127134001543	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1127134001544	dimerization interface [polypeptide binding]; other site
1127134001545	putative ATP binding site [chemical binding]; other site
1127134001546	L-asparaginase II; Region: Asparaginase_II; pfam06089
1127134001547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1127134001548	MOSC domain; Region: MOSC; pfam03473
1127134001549	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1127134001550	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1127134001551	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1127134001552	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
1127134001553	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1127134001554	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134001555	catalytic residue [active]
1127134001556	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1127134001557	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1127134001558	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1127134001559	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
1127134001560	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134001561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134001562	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1127134001563	Walker A/P-loop; other site
1127134001564	ATP binding site [chemical binding]; other site
1127134001565	Q-loop/lid; other site
1127134001566	ABC transporter signature motif; other site
1127134001567	Walker B; other site
1127134001568	D-loop; other site
1127134001569	H-loop/switch region; other site
1127134001570	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
1127134001571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134001572	Walker A/P-loop; other site
1127134001573	ATP binding site [chemical binding]; other site
1127134001574	ABC transporter signature motif; other site
1127134001575	Walker B; other site
1127134001576	D-loop; other site
1127134001577	H-loop/switch region; other site
1127134001578	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1127134001579	heme-binding site [chemical binding]; other site
1127134001580	Protein of unknown function (DUF1416); Region: DUF1416; pfam07210
1127134001581	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1127134001582	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1127134001583	active site residue [active]
1127134001584	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1127134001585	active site residue [active]
1127134001586	Domain of unknown function (DUF4395); Region: DUF4395; pfam14340
1127134001587	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1127134001588	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1127134001589	catalytic residues [active]
1127134001590	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1127134001591	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134001592	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134001593	DNA binding site [nucleotide binding]
1127134001594	mycothiol synthase; Region: mycothiol_MshD; TIGR03448
1127134001595	PBP superfamily domain; Region: PBP_like_2; cl17296
1127134001596	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1127134001597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134001598	dimer interface [polypeptide binding]; other site
1127134001599	conserved gate region; other site
1127134001600	putative PBP binding loops; other site
1127134001601	ABC-ATPase subunit interface; other site
1127134001602	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1127134001603	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134001604	dimer interface [polypeptide binding]; other site
1127134001605	conserved gate region; other site
1127134001606	putative PBP binding loops; other site
1127134001607	ABC-ATPase subunit interface; other site
1127134001608	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
1127134001609	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1127134001610	Walker A/P-loop; other site
1127134001611	ATP binding site [chemical binding]; other site
1127134001612	Q-loop/lid; other site
1127134001613	ABC transporter signature motif; other site
1127134001614	Walker B; other site
1127134001615	D-loop; other site
1127134001616	H-loop/switch region; other site
1127134001617	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1127134001618	PhoU domain; Region: PhoU; pfam01895
1127134001619	PhoU domain; Region: PhoU; pfam01895
1127134001620	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1127134001621	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1127134001622	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1127134001623	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1127134001624	FMN binding site [chemical binding]; other site
1127134001625	active site
1127134001626	catalytic residues [active]
1127134001627	substrate binding site [chemical binding]; other site
1127134001628	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1127134001629	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1127134001630	homodimer interface [polypeptide binding]; other site
1127134001631	putative substrate binding pocket [chemical binding]; other site
1127134001632	diiron center [ion binding]; other site
1127134001633	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1127134001634	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1127134001635	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134001636	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1127134001637	Ligand binding site; other site
1127134001638	Putative Catalytic site; other site
1127134001639	DXD motif; other site
1127134001640	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1127134001641	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1127134001642	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134001643	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1127134001644	putative acyl-acceptor binding pocket; other site
1127134001645	glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355
1127134001646	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
1127134001647	putative acyl-acceptor binding pocket; other site
1127134001648	salicylate synthase MbtI; Reviewed; Region: PRK07912
1127134001649	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1127134001650	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
1127134001651	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
1127134001652	acyl-activating enzyme (AAE) consensus motif; other site
1127134001653	active site
1127134001654	AMP binding site [chemical binding]; other site
1127134001655	substrate binding site [chemical binding]; other site
1127134001656	short chain dehydrogenase; Provisional; Region: PRK06197
1127134001657	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1127134001658	putative NAD(P) binding site [chemical binding]; other site
1127134001659	active site
1127134001660	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1127134001661	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1127134001662	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
1127134001663	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1127134001664	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134001665	S-adenosylmethionine binding site [chemical binding]; other site
1127134001666	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1127134001667	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1127134001668	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1127134001669	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134001670	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134001671	DNA binding residues [nucleotide binding]
1127134001672	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134001673	aminotransferase; Validated; Region: PRK07777
1127134001674	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134001675	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134001676	homodimer interface [polypeptide binding]; other site
1127134001677	catalytic residue [active]
1127134001678	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1127134001679	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1127134001680	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1127134001681	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134001682	ATP binding site [chemical binding]; other site
1127134001683	putative Mg++ binding site [ion binding]; other site
1127134001684	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134001685	nucleotide binding region [chemical binding]; other site
1127134001686	ATP-binding site [chemical binding]; other site
1127134001687	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
1127134001688	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1127134001689	Zn binding site [ion binding]; other site
1127134001690	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1127134001691	WYL domain; Region: WYL; pfam13280
1127134001692	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1127134001693	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1127134001694	DNA-binding site [nucleotide binding]; DNA binding site
1127134001695	RNA-binding motif; other site
1127134001696	Protein of unknown function (DUF2771); Region: DUF2771; pfam10969
1127134001697	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1127134001698	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1127134001699	Probable transposase; Region: OrfB_IS605; pfam01385
1127134001700	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1127134001701	Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823
1127134001702	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
1127134001703	Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326
1127134001704	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134001705	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134001706	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734
1127134001707	Protein of unknown function (DUF2530); Region: DUF2530; pfam10745
1127134001708	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134001709	MarR family; Region: MarR; pfam01047
1127134001710	hypothetical protein; Provisional; Region: PRK11770
1127134001711	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1127134001712	Domain of unknown function (DUF307); Region: DUF307; pfam03733
1127134001713	hypothetical protein; Provisional; Region: PRK01346
1127134001714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134001715	Coenzyme A binding pocket [chemical binding]; other site
1127134001716	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1127134001717	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1127134001718	Protein of unknown function (DUF2537); Region: DUF2537; pfam10801
1127134001719	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134001720	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134001721	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134001722	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
1127134001723	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134001724	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134001725	catalytic residue [active]
1127134001726	citrate synthase 2; Provisional; Region: PRK12350
1127134001727	Citrate synthase; Region: Citrate_synt; pfam00285
1127134001728	oxalacetate binding site [chemical binding]; other site
1127134001729	citrylCoA binding site [chemical binding]; other site
1127134001730	coenzyme A binding site [chemical binding]; other site
1127134001731	catalytic triad [active]
1127134001732	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
1127134001733	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1127134001734	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1127134001735	H+ Antiporter protein; Region: 2A0121; TIGR00900
1127134001736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134001737	putative substrate translocation pore; other site
1127134001738	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1127134001739	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1127134001740	dimer interface [polypeptide binding]; other site
1127134001741	active site
1127134001742	citrylCoA binding site [chemical binding]; other site
1127134001743	NADH binding [chemical binding]; other site
1127134001744	cationic pore residues; other site
1127134001745	oxalacetate/citrate binding site [chemical binding]; other site
1127134001746	coenzyme A binding site [chemical binding]; other site
1127134001747	catalytic triad [active]
1127134001748	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1127134001749	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134001750	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1127134001751	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134001752	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134001753	DNA binding residues [nucleotide binding]
1127134001754	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134001755	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1127134001756	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1127134001757	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1127134001758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134001759	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134001760	dimer interface [polypeptide binding]; other site
1127134001761	phosphorylation site [posttranslational modification]
1127134001762	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134001763	Mg2+ binding site [ion binding]; other site
1127134001764	G-X-G motif; other site
1127134001765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134001766	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134001767	active site
1127134001768	phosphorylation site [posttranslational modification]
1127134001769	intermolecular recognition site; other site
1127134001770	dimerization interface [polypeptide binding]; other site
1127134001771	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134001772	DNA binding site [nucleotide binding]
1127134001773	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1127134001774	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001775	acyl-activating enzyme (AAE) consensus motif; other site
1127134001776	AMP binding site [chemical binding]; other site
1127134001777	active site
1127134001778	CoA binding site [chemical binding]; other site
1127134001779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134001780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134001781	ATP binding site [chemical binding]; other site
1127134001782	Mg2+ binding site [ion binding]; other site
1127134001783	G-X-G motif; other site
1127134001784	Roadblock/LC7 domain; Region: Robl_LC7; cl00886
1127134001785	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1127134001786	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1127134001787	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1127134001788	G1 box; other site
1127134001789	GTP/Mg2+ binding site [chemical binding]; other site
1127134001790	G2 box; other site
1127134001791	Switch I region; other site
1127134001792	G3 box; other site
1127134001793	Switch II region; other site
1127134001794	G4 box; other site
1127134001795	G5 box; other site
1127134001796	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1127134001797	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134001798	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134001799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134001800	sequence-specific DNA binding site [nucleotide binding]; other site
1127134001801	salt bridge; other site
1127134001802	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134001803	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134001804	active site
1127134001805	catalytic tetrad [active]
1127134001806	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134001807	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134001808	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134001809	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134001810	substrate binding site [chemical binding]; other site
1127134001811	oxyanion hole (OAH) forming residues; other site
1127134001812	trimer interface [polypeptide binding]; other site
1127134001813	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1127134001814	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1127134001815	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1127134001816	ATP-dependent DNA ligase; Reviewed; Region: PRK09632
1127134001817	MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863
1127134001818	nucleotide binding site [chemical binding]; other site
1127134001819	DNA polymerase Ligase (LigD); Region: LigD_N; cl11819
1127134001820	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1127134001821	active site
1127134001822	DNA binding site [nucleotide binding]
1127134001823	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1127134001824	DNA binding site [nucleotide binding]
1127134001825	MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013
1127134001826	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1127134001827	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
1127134001828	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1127134001829	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1127134001830	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1127134001831	Walker A/P-loop; other site
1127134001832	ATP binding site [chemical binding]; other site
1127134001833	Q-loop/lid; other site
1127134001834	ABC transporter signature motif; other site
1127134001835	Walker B; other site
1127134001836	D-loop; other site
1127134001837	H-loop/switch region; other site
1127134001838	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1127134001839	Walker A/P-loop; other site
1127134001840	ATP binding site [chemical binding]; other site
1127134001841	Q-loop/lid; other site
1127134001842	ABC transporter signature motif; other site
1127134001843	Walker B; other site
1127134001844	D-loop; other site
1127134001845	H-loop/switch region; other site
1127134001846	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1127134001847	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134001848	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134001849	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134001850	RibD C-terminal domain; Region: RibD_C; cl17279
1127134001851	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1127134001852	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1127134001853	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1127134001854	active site
1127134001855	metal binding site [ion binding]; metal-binding site
1127134001856	hexamer interface [polypeptide binding]; other site
1127134001857	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1127134001858	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1127134001859	active site
1127134001860	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1127134001861	cyclase homology domain; Region: CHD; cd07302
1127134001862	nucleotidyl binding site; other site
1127134001863	metal binding site [ion binding]; metal-binding site
1127134001864	dimer interface [polypeptide binding]; other site
1127134001865	Predicted acyl esterases [General function prediction only]; Region: COG2936
1127134001866	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134001867	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1127134001868	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134001869	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134001870	S-adenosylmethionine binding site [chemical binding]; other site
1127134001871	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1127134001872	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134001873	non-specific DNA binding site [nucleotide binding]; other site
1127134001874	salt bridge; other site
1127134001875	sequence-specific DNA binding site [nucleotide binding]; other site
1127134001876	Cupin domain; Region: Cupin_2; pfam07883
1127134001877	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
1127134001878	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134001879	dimer interface [polypeptide binding]; other site
1127134001880	active site
1127134001881	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134001882	Ligand Binding Site [chemical binding]; other site
1127134001883	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134001884	Ligand Binding Site [chemical binding]; other site
1127134001885	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1127134001886	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134001887	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1127134001888	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134001889	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134001890	NAD(P) binding site [chemical binding]; other site
1127134001891	catalytic residues [active]
1127134001892	choline dehydrogenase; Validated; Region: PRK02106
1127134001893	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134001894	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1127134001895	amino acid carrier protein; Region: agcS; TIGR00835
1127134001896	BCCT family transporter; Region: BCCT; pfam02028
1127134001897	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
1127134001898	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134001899	substrate binding pocket [chemical binding]; other site
1127134001900	membrane-bound complex binding site; other site
1127134001901	hinge residues; other site
1127134001902	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1127134001903	Thioredoxin; Region: Thioredoxin_4; cl17273
1127134001904	RibD C-terminal domain; Region: RibD_C; cl17279
1127134001905	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134001906	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
1127134001907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134001908	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134001909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134001910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134001911	Bacterial transcriptional repressor; Region: TetR; pfam13972
1127134001912	RibD C-terminal domain; Region: RibD_C; cl17279
1127134001913	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134001914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134001915	non-specific DNA binding site [nucleotide binding]; other site
1127134001916	salt bridge; other site
1127134001917	sequence-specific DNA binding site [nucleotide binding]; other site
1127134001918	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1127134001919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134001920	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134001921	NAD(P) binding site [chemical binding]; other site
1127134001922	active site
1127134001923	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134001924	Thioesterase; Region: PKS_TE; smart00824
1127134001925	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1127134001926	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134001927	non-specific DNA binding site [nucleotide binding]; other site
1127134001928	salt bridge; other site
1127134001929	sequence-specific DNA binding site [nucleotide binding]; other site
1127134001930	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1127134001931	putative active site pocket [active]
1127134001932	cleavage site
1127134001933	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1127134001934	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134001935	DNA binding residues [nucleotide binding]
1127134001936	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134001937	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134001938	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1127134001939	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1127134001940	dimer interface [polypeptide binding]; other site
1127134001941	acyl-activating enzyme (AAE) consensus motif; other site
1127134001942	putative active site [active]
1127134001943	AMP binding site [chemical binding]; other site
1127134001944	putative CoA binding site [chemical binding]; other site
1127134001945	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134001946	Nitronate monooxygenase; Region: NMO; pfam03060
1127134001947	FMN binding site [chemical binding]; other site
1127134001948	substrate binding site [chemical binding]; other site
1127134001949	putative catalytic residue [active]
1127134001950	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1127134001951	Peptidase family M23; Region: Peptidase_M23; pfam01551
1127134001952	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134001953	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001954	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134001955	acyl-activating enzyme (AAE) consensus motif; other site
1127134001956	AMP binding site [chemical binding]; other site
1127134001957	Condensation domain; Region: Condensation; pfam00668
1127134001958	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134001959	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134001960	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001961	acyl-activating enzyme (AAE) consensus motif; other site
1127134001962	AMP binding site [chemical binding]; other site
1127134001963	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134001964	Condensation domain; Region: Condensation; pfam00668
1127134001965	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134001966	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134001967	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001968	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001969	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134001970	acyl-activating enzyme (AAE) consensus motif; other site
1127134001971	AMP binding site [chemical binding]; other site
1127134001972	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134001973	Condensation domain; Region: Condensation; pfam00668
1127134001974	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134001975	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134001976	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001977	acyl-activating enzyme (AAE) consensus motif; other site
1127134001978	AMP binding site [chemical binding]; other site
1127134001979	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134001980	Condensation domain; Region: Condensation; pfam00668
1127134001981	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134001982	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134001983	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001984	acyl-activating enzyme (AAE) consensus motif; other site
1127134001985	AMP binding site [chemical binding]; other site
1127134001986	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134001987	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134001988	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1127134001989	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134001990	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001991	acyl-activating enzyme (AAE) consensus motif; other site
1127134001992	AMP binding site [chemical binding]; other site
1127134001993	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134001994	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134001995	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134001996	acyl-activating enzyme (AAE) consensus motif; other site
1127134001997	AMP binding site [chemical binding]; other site
1127134001998	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134001999	Condensation domain; Region: Condensation; pfam00668
1127134002000	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134002001	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134002002	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002003	acyl-activating enzyme (AAE) consensus motif; other site
1127134002004	AMP binding site [chemical binding]; other site
1127134002005	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002006	Condensation domain; Region: Condensation; pfam00668
1127134002007	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134002008	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134002009	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002010	acyl-activating enzyme (AAE) consensus motif; other site
1127134002011	AMP binding site [chemical binding]; other site
1127134002012	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002013	Condensation domain; Region: Condensation; pfam00668
1127134002014	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134002015	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134002016	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002017	acyl-activating enzyme (AAE) consensus motif; other site
1127134002018	AMP binding site [chemical binding]; other site
1127134002019	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1127134002020	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1127134002021	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002022	acyl-activating enzyme (AAE) consensus motif; other site
1127134002023	AMP binding site [chemical binding]; other site
1127134002024	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002025	Putative esterase; Region: Esterase; pfam00756
1127134002026	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134002027	NAD(P) binding site [chemical binding]; other site
1127134002028	active site
1127134002029	enoyl-CoA hydratase; Provisional; Region: PRK06688
1127134002030	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134002031	substrate binding site [chemical binding]; other site
1127134002032	oxyanion hole (OAH) forming residues; other site
1127134002033	trimer interface [polypeptide binding]; other site
1127134002034	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1127134002035	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134002036	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002037	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002038	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134002039	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
1127134002040	NAD(P) binding site [chemical binding]; other site
1127134002041	catalytic residues [active]
1127134002042	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134002043	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134002044	Walker A/P-loop; other site
1127134002045	ATP binding site [chemical binding]; other site
1127134002046	Q-loop/lid; other site
1127134002047	ABC transporter signature motif; other site
1127134002048	Walker B; other site
1127134002049	D-loop; other site
1127134002050	H-loop/switch region; other site
1127134002051	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134002052	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134002053	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134002054	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134002055	lycopene cyclase; Region: lycopene_cycl; TIGR01789
1127134002056	Putative esterase; Region: Esterase; pfam00756
1127134002057	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134002058	PGAP1-like protein; Region: PGAP1; pfam07819
1127134002059	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134002060	CoenzymeA binding site [chemical binding]; other site
1127134002061	subunit interaction site [polypeptide binding]; other site
1127134002062	PHB binding site; other site
1127134002063	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1127134002064	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1127134002065	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1127134002066	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1127134002067	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1127134002068	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1127134002069	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1127134002070	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1127134002071	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1127134002072	putative translocon binding site; other site
1127134002073	protein-rRNA interface [nucleotide binding]; other site
1127134002074	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1127134002075	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1127134002076	G-X-X-G motif; other site
1127134002077	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1127134002078	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1127134002079	23S rRNA interface [nucleotide binding]; other site
1127134002080	5S rRNA interface [nucleotide binding]; other site
1127134002081	putative antibiotic binding site [chemical binding]; other site
1127134002082	L25 interface [polypeptide binding]; other site
1127134002083	L27 interface [polypeptide binding]; other site
1127134002084	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1127134002085	23S rRNA interface [nucleotide binding]; other site
1127134002086	putative translocon interaction site; other site
1127134002087	signal recognition particle (SRP54) interaction site; other site
1127134002088	L23 interface [polypeptide binding]; other site
1127134002089	trigger factor interaction site; other site
1127134002090	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1127134002091	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134002092	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1127134002093	CAAX protease self-immunity; Region: Abi; pfam02517
1127134002094	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1127134002095	Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558
1127134002096	probable active site [active]
1127134002097	PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667
1127134002098	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134002099	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134002100	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134002101	Walker A/P-loop; other site
1127134002102	ATP binding site [chemical binding]; other site
1127134002103	Q-loop/lid; other site
1127134002104	ABC transporter signature motif; other site
1127134002105	Walker B; other site
1127134002106	D-loop; other site
1127134002107	H-loop/switch region; other site
1127134002108	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134002109	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134002110	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1127134002111	Walker A/P-loop; other site
1127134002112	ATP binding site [chemical binding]; other site
1127134002113	Q-loop/lid; other site
1127134002114	ABC transporter signature motif; other site
1127134002115	Walker B; other site
1127134002116	D-loop; other site
1127134002117	H-loop/switch region; other site
1127134002118	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134002119	non-specific DNA binding site [nucleotide binding]; other site
1127134002120	salt bridge; other site
1127134002121	sequence-specific DNA binding site [nucleotide binding]; other site
1127134002122	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1127134002123	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134002124	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1127134002125	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1127134002126	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1127134002127	FAD binding pocket [chemical binding]; other site
1127134002128	FAD binding motif [chemical binding]; other site
1127134002129	phosphate binding motif [ion binding]; other site
1127134002130	NAD binding pocket [chemical binding]; other site
1127134002131	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134002132	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134002133	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
1127134002134	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
1127134002135	active site
1127134002136	substrate binding site [chemical binding]; other site
1127134002137	cosubstrate binding site; other site
1127134002138	catalytic site [active]
1127134002139	Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911
1127134002140	Condensation domain; Region: Condensation; pfam00668
1127134002141	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002142	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134002143	acyl-activating enzyme (AAE) consensus motif; other site
1127134002144	AMP binding site [chemical binding]; other site
1127134002145	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002146	Condensation domain; Region: Condensation; pfam00668
1127134002147	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134002148	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134002149	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134002150	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1127134002151	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1127134002152	intersubunit interface [polypeptide binding]; other site
1127134002153	Condensation domain; Region: Condensation; pfam00668
1127134002154	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002155	Condensation domain; Region: Condensation; pfam00668
1127134002156	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134002157	AMP-binding enzyme; Region: AMP-binding; pfam00501
1127134002158	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002159	acyl-activating enzyme (AAE) consensus motif; other site
1127134002160	AMP binding site [chemical binding]; other site
1127134002161	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002162	Condensation domain; Region: Condensation; pfam00668
1127134002163	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1127134002164	Condensation domain; Region: Condensation; pfam00668
1127134002165	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134002166	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1127134002167	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1127134002168	acyl-activating enzyme (AAE) consensus motif; other site
1127134002169	AMP binding site [chemical binding]; other site
1127134002170	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002171	Condensation domain; Region: Condensation; pfam00668
1127134002172	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134002173	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134002174	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134002175	acyl-activating enzyme (AAE) consensus motif; other site
1127134002176	AMP binding site [chemical binding]; other site
1127134002177	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134002178	Condensation domain; Region: Condensation; pfam00668
1127134002179	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1127134002180	Condensation domain; Region: Condensation; pfam00668
1127134002181	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134002182	Thioesterase domain; Region: Thioesterase; pfam00975
1127134002183	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1127134002184	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1127134002185	active site
1127134002186	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1127134002187	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1127134002188	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
1127134002189	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1127134002190	NADP binding site [chemical binding]; other site
1127134002191	active site
1127134002192	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134002193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134002194	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134002195	Walker A/P-loop; other site
1127134002196	ATP binding site [chemical binding]; other site
1127134002197	Q-loop/lid; other site
1127134002198	ABC transporter signature motif; other site
1127134002199	Walker B; other site
1127134002200	D-loop; other site
1127134002201	H-loop/switch region; other site
1127134002202	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134002203	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134002204	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134002205	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134002206	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
1127134002207	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134002208	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134002209	putative substrate translocation pore; other site
1127134002210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134002211	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134002212	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002213	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134002214	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1127134002215	putative active site [active]
1127134002216	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1127134002217	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1127134002218	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1127134002219	active site
1127134002220	Zn binding site [ion binding]; other site
1127134002221	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1127134002222	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1127134002223	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1127134002224	RNA binding site [nucleotide binding]; other site
1127134002225	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1127134002226	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1127134002227	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1127134002228	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1127134002229	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1127134002230	putative active site [active]
1127134002231	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134002232	Walker A/P-loop; other site
1127134002233	ATP binding site [chemical binding]; other site
1127134002234	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1127134002235	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1127134002236	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1127134002237	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1127134002238	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1127134002239	5S rRNA interface [nucleotide binding]; other site
1127134002240	L27 interface [polypeptide binding]; other site
1127134002241	23S rRNA interface [nucleotide binding]; other site
1127134002242	L5 interface [polypeptide binding]; other site
1127134002243	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1127134002244	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1127134002245	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1127134002246	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1127134002247	23S rRNA binding site [nucleotide binding]; other site
1127134002248	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1127134002249	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1127134002250	SecY translocase; Region: SecY; pfam00344
1127134002251	adenylate kinase; Reviewed; Region: adk; PRK00279
1127134002252	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1127134002253	AMP-binding site [chemical binding]; other site
1127134002254	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1127134002255	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1127134002256	active site
1127134002257	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1127134002258	dimerization interface [polypeptide binding]; other site
1127134002259	putative tRNAtyr binding site [nucleotide binding]; other site
1127134002260	putative active site [active]
1127134002261	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
1127134002262	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134002263	EspG family; Region: ESX-1_EspG; pfam14011
1127134002264	PPE-repeat proteins [Cell motility and secretion]; Region: COG5651
1127134002265	PPE family; Region: PPE; pfam00823
1127134002266	EspG family; Region: ESX-1_EspG; pfam14011
1127134002267	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1127134002268	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
1127134002269	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1127134002270	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134002271	Walker A motif; other site
1127134002272	ATP binding site [chemical binding]; other site
1127134002273	Walker B motif; other site
1127134002274	arginine finger; other site
1127134002275	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1127134002276	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1127134002277	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1127134002278	active site
1127134002279	catalytic residues [active]
1127134002280	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1127134002281	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002282	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1127134002283	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002284	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002285	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002286	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134002287	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1127134002288	Coenzyme A binding pocket [chemical binding]; other site
1127134002289	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1127134002290	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1127134002291	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1127134002292	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1127134002293	rRNA binding site [nucleotide binding]; other site
1127134002294	predicted 30S ribosome binding site; other site
1127134002295	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1127134002296	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1127134002297	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1127134002298	30S ribosomal protein S11; Validated; Region: PRK05309
1127134002299	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1127134002300	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1127134002301	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1127134002302	RNA binding surface [nucleotide binding]; other site
1127134002303	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1127134002304	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1127134002305	alphaNTD - beta interaction site [polypeptide binding]; other site
1127134002306	alphaNTD homodimer interface [polypeptide binding]; other site
1127134002307	alphaNTD - beta' interaction site [polypeptide binding]; other site
1127134002308	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1127134002309	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1127134002310	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1127134002311	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1127134002312	dimerization interface 3.5A [polypeptide binding]; other site
1127134002313	active site
1127134002315	Evidence 4 : Homologs of previously reported genes of unknown function
1127134002316	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1127134002317	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1127134002318	putative dimer interface [polypeptide binding]; other site
1127134002319	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134002320	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1127134002321	putative substrate translocation pore; other site
1127134002322	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134002323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134002324	active site
1127134002325	phosphorylation site [posttranslational modification]
1127134002326	intermolecular recognition site; other site
1127134002327	dimerization interface [polypeptide binding]; other site
1127134002328	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134002329	DNA binding site [nucleotide binding]
1127134002330	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134002331	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134002332	ATP binding site [chemical binding]; other site
1127134002333	Mg2+ binding site [ion binding]; other site
1127134002334	G-X-G motif; other site
1127134002335	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1127134002336	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1127134002337	putative homodimer interface [polypeptide binding]; other site
1127134002338	putative homotetramer interface [polypeptide binding]; other site
1127134002339	putative allosteric switch controlling residues; other site
1127134002340	putative metal binding site [ion binding]; other site
1127134002341	putative homodimer-homodimer interface [polypeptide binding]; other site
1127134002342	5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823
1127134002343	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134002344	Predicted flavoprotein [General function prediction only]; Region: COG0431
1127134002345	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1127134002346	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
1127134002347	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1127134002348	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1127134002349	active site
1127134002350	catalytic residues [active]
1127134002351	type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920
1127134002352	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1127134002353	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002354	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1127134002355	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002356	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134002357	type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931
1127134002358	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1127134002359	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1127134002360	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134002361	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134002362	active site
1127134002363	ATP binding site [chemical binding]; other site
1127134002364	substrate binding site [chemical binding]; other site
1127134002365	activation loop (A-loop); other site
1127134002366	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134002367	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134002368	active site
1127134002369	ATP binding site [chemical binding]; other site
1127134002370	substrate binding site [chemical binding]; other site
1127134002371	activation loop (A-loop); other site
1127134002372	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134002373	phosphopeptide binding site; other site
1127134002374	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1127134002375	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134002376	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134002377	phosphopeptide binding site; other site
1127134002378	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134002379	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134002380	phosphopeptide binding site; other site
1127134002381	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1127134002382	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1127134002383	Walker A/P-loop; other site
1127134002384	ATP binding site [chemical binding]; other site
1127134002385	Q-loop/lid; other site
1127134002386	ABC transporter signature motif; other site
1127134002387	Walker B; other site
1127134002388	D-loop; other site
1127134002389	H-loop/switch region; other site
1127134002390	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1127134002391	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1127134002392	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1127134002393	23S rRNA interface [nucleotide binding]; other site
1127134002394	L3 interface [polypeptide binding]; other site
1127134002395	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1127134002396	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
1127134002397	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1127134002398	active site
1127134002399	substrate binding site [chemical binding]; other site
1127134002400	metal binding site [ion binding]; metal-binding site
1127134002401	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134002402	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134002403	active site
1127134002404	ATP binding site [chemical binding]; other site
1127134002405	substrate binding site [chemical binding]; other site
1127134002406	activation loop (A-loop); other site
1127134002407	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1127134002408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134002409	Walker A/P-loop; other site
1127134002410	ATP binding site [chemical binding]; other site
1127134002411	Q-loop/lid; other site
1127134002412	ABC transporter signature motif; other site
1127134002413	Walker B; other site
1127134002414	D-loop; other site
1127134002415	H-loop/switch region; other site
1127134002416	ABC transporter; Region: ABC_tran_2; pfam12848
1127134002417	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134002418	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
1127134002419	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1127134002420	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1127134002421	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1127134002422	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1127134002423	glutaminase active site [active]
1127134002424	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1127134002425	dimer interface [polypeptide binding]; other site
1127134002426	active site
1127134002427	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1127134002428	dimer interface [polypeptide binding]; other site
1127134002429	active site
1127134002430	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1127134002431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134002432	putative substrate translocation pore; other site
1127134002433	MarR family; Region: MarR; pfam01047
1127134002434	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1127134002435	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1127134002436	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
1127134002437	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1127134002438	putative substrate binding site [chemical binding]; other site
1127134002439	putative ATP binding site [chemical binding]; other site
1127134002440	alanine racemase; Reviewed; Region: alr; PRK00053
1127134002441	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1127134002442	active site
1127134002443	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134002444	dimer interface [polypeptide binding]; other site
1127134002445	substrate binding site [chemical binding]; other site
1127134002446	catalytic residues [active]
1127134002447	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134002448	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1127134002449	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1127134002450	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1127134002451	Glycoprotease family; Region: Peptidase_M22; pfam00814
1127134002452	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1127134002453	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134002454	Coenzyme A binding pocket [chemical binding]; other site
1127134002455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134002456	UGMP family protein; Validated; Region: PRK09604
1127134002457	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134002458	nucleotide binding site [chemical binding]; other site
1127134002459	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1127134002460	oligomerisation interface [polypeptide binding]; other site
1127134002461	mobile loop; other site
1127134002462	roof hairpin; other site
1127134002463	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1127134002464	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1127134002465	ring oligomerisation interface [polypeptide binding]; other site
1127134002466	ATP/Mg binding site [chemical binding]; other site
1127134002467	stacking interactions; other site
1127134002468	hinge regions; other site
1127134002469	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1127134002470	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134002471	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134002472	DNA binding residues [nucleotide binding]
1127134002473	Transcription factor WhiB; Region: Whib; pfam02467
1127134002474	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1127134002475	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134002476	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134002477	DNA binding residues [nucleotide binding]
1127134002478	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1127134002479	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1127134002480	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1127134002481	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1127134002482	active site
1127134002483	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1127134002484	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1127134002485	active site
1127134002486	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1127134002487	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1127134002488	GMP synthase; Reviewed; Region: guaA; PRK00074
1127134002489	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1127134002490	AMP/PPi binding site [chemical binding]; other site
1127134002491	candidate oxyanion hole; other site
1127134002492	catalytic triad [active]
1127134002493	potential glutamine specificity residues [chemical binding]; other site
1127134002494	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1127134002495	ATP Binding subdomain [chemical binding]; other site
1127134002496	Ligand Binding sites [chemical binding]; other site
1127134002497	Dimerization subdomain; other site
1127134002498	PspC domain; Region: PspC; pfam04024
1127134002499	PspC domain; Region: PspC; pfam04024
1127134002500	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1127134002501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1127134002502	Mg2+ binding site [ion binding]; other site
1127134002503	G-X-G motif; other site
1127134002504	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134002505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134002506	active site
1127134002507	phosphorylation site [posttranslational modification]
1127134002508	intermolecular recognition site; other site
1127134002509	dimerization interface [polypeptide binding]; other site
1127134002510	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134002511	DNA binding residues [nucleotide binding]
1127134002512	dimerization interface [polypeptide binding]; other site
1127134002513	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134002514	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134002515	active site
1127134002516	ATP binding site [chemical binding]; other site
1127134002517	substrate binding site [chemical binding]; other site
1127134002518	activation loop (A-loop); other site
1127134002519	Y-family of DNA polymerases; Region: PolY; cl12025
1127134002520	active site
1127134002521	DNA binding site [nucleotide binding]
1127134002522	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134002523	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134002524	short chain dehydrogenase; Provisional; Region: PRK07109
1127134002525	classical (c) SDRs; Region: SDR_c; cd05233
1127134002526	NAD(P) binding site [chemical binding]; other site
1127134002527	active site
1127134002528	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1127134002529	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1127134002530	active site
1127134002531	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1127134002532	generic binding surface II; other site
1127134002533	generic binding surface I; other site
1127134002534	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
1127134002535	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1127134002536	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1127134002537	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1127134002538	catalytic residues [active]
1127134002539	Recombinase; Region: Recombinase; pfam07508
1127134002540	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1127134002541	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134002542	non-specific DNA binding site [nucleotide binding]; other site
1127134002543	salt bridge; other site
1127134002544	sequence-specific DNA binding site [nucleotide binding]; other site
1127134002545	Helix-turn-helix domain; Region: HTH_36; pfam13730
1127134002546	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1127134002547	homotrimer interaction site [polypeptide binding]; other site
1127134002548	putative active site [active]
1127134002549	Protein of unknown function (DUF3017); Region: DUF3017; pfam11222
1127134002550	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
1127134002551	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
1127134002552	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
1127134002553	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1127134002554	homodimer interface [polypeptide binding]; other site
1127134002555	substrate-cofactor binding pocket; other site
1127134002556	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134002557	catalytic residue [active]
1127134002558	isocitrate dehydrogenase; Validated; Region: PRK08299
1127134002559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134002560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002561	lipid-transfer protein; Provisional; Region: PRK08256
1127134002562	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134002563	active site
1127134002564	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1127134002565	hydrophobic ligand binding site; other site
1127134002566	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134002567	active site
1127134002568	catalytic site [active]
1127134002569	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134002570	active site 2 [active]
1127134002571	active site 1 [active]
1127134002572	short chain dehydrogenase; Provisional; Region: PRK07791
1127134002573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134002574	NAD(P) binding site [chemical binding]; other site
1127134002575	active site
1127134002576	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134002577	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134002578	active site
1127134002579	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
1127134002580	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134002581	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134002582	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134002583	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
1127134002584	putative active site [active]
1127134002585	putative catalytic site [active]
1127134002586	putative DNA binding site [nucleotide binding]; other site
1127134002587	putative phosphate binding site [ion binding]; other site
1127134002588	metal binding site A [ion binding]; metal-binding site
1127134002589	putative AP binding site [nucleotide binding]; other site
1127134002590	putative metal binding site B [ion binding]; other site
1127134002591	ribonuclease; Region: Ribonuclease; pfam00545
1127134002592	active site
1127134002593	Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141
1127134002594	putative RNAase interaction site [polypeptide binding]; other site
1127134002595	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134002596	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1127134002597	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1127134002598	active site
1127134002599	HIGH motif; other site
1127134002600	dimer interface [polypeptide binding]; other site
1127134002601	KMSKS motif; other site
1127134002602	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1127134002603	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1127134002604	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1127134002605	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1127134002606	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1127134002607	metal binding site [ion binding]; metal-binding site
1127134002608	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1127134002609	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1127134002610	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1127134002611	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1127134002612	ABC-ATPase subunit  interface; other site
1127134002613	dimer interface [polypeptide binding]; other site
1127134002614	putative PBP binding regions; other site
1127134002615	hypothetical protein; Reviewed; Region: PRK00024
1127134002616	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1127134002617	MPN+ (JAMM) motif; other site
1127134002618	Zinc-binding site [ion binding]; other site
1127134002619	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
1127134002620	cofactor binding site; other site
1127134002621	metal binding site [ion binding]; metal-binding site
1127134002622	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
1127134002623	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
1127134002624	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1127134002625	putative active site [active]
1127134002626	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1127134002627	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1127134002628	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
1127134002629	L-aspartate oxidase; Provisional; Region: PRK06175
1127134002630	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1127134002631	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500
1127134002632	putative Iron-sulfur protein interface [polypeptide binding]; other site
1127134002633	putative proximal heme binding site [chemical binding]; other site
1127134002634	putative SdhC-like subunit interface [polypeptide binding]; other site
1127134002635	putative distal heme binding site [chemical binding]; other site
1127134002636	Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501
1127134002637	putative Iron-sulfur protein interface [polypeptide binding]; other site
1127134002638	putative proximal heme binding site [chemical binding]; other site
1127134002639	putative SdhD-like interface [polypeptide binding]; other site
1127134002640	putative distal heme binding site [chemical binding]; other site
1127134002641	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
1127134002642	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1127134002643	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1127134002644	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1127134002645	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
1127134002646	adenosine deaminase; Provisional; Region: PRK09358
1127134002647	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1127134002648	active site
1127134002649	NlpC/P60 family; Region: NLPC_P60; pfam00877
1127134002650	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134002651	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134002652	active site
1127134002653	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1127134002654	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1127134002655	active site
1127134002656	substrate binding site [chemical binding]; other site
1127134002657	metal binding site [ion binding]; metal-binding site
1127134002658	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1127134002659	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134002660	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134002661	substrate binding site [chemical binding]; other site
1127134002662	oxyanion hole (OAH) forming residues; other site
1127134002663	trimer interface [polypeptide binding]; other site
1127134002664	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1127134002665	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1127134002666	metal binding site [ion binding]; metal-binding site
1127134002667	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1127134002668	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014
1127134002669	metal binding site [ion binding]; metal-binding site
1127134002670	putative dimer interface [polypeptide binding]; other site
1127134002671	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1127134002672	putative active site pocket [active]
1127134002673	dimerization interface [polypeptide binding]; other site
1127134002674	putative catalytic residue [active]
1127134002675	flavoprotein disulfide reductase; Reviewed; Region: PRK07845
1127134002676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134002677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134002678	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1127134002679	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1127134002680	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134002681	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134002682	homodimer interface [polypeptide binding]; other site
1127134002683	catalytic residue [active]
1127134002684	glycerol kinase; Provisional; Region: glpK; PRK00047
1127134002685	Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789
1127134002686	N- and C-terminal domain interface [polypeptide binding]; other site
1127134002687	active site
1127134002688	MgATP binding site [chemical binding]; other site
1127134002689	catalytic site [active]
1127134002690	metal binding site [ion binding]; metal-binding site
1127134002691	putative homotetramer interface [polypeptide binding]; other site
1127134002692	glycerol binding site [chemical binding]; other site
1127134002693	homodimer interface [polypeptide binding]; other site
1127134002694	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1127134002695	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134002696	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134002697	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002698	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1127134002699	N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971
1127134002700	putative DNA binding site [nucleotide binding]; other site
1127134002701	catalytic residue [active]
1127134002702	putative H2TH interface [polypeptide binding]; other site
1127134002703	putative catalytic residues [active]
1127134002704	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1127134002705	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1127134002706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134002707	putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751
1127134002708	ATP binding site [chemical binding]; other site
1127134002709	putative Mg++ binding site [ion binding]; other site
1127134002710	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134002711	nucleotide binding region [chemical binding]; other site
1127134002712	ATP-binding site [chemical binding]; other site
1127134002713	DEAD/H associated; Region: DEAD_assoc; pfam08494
1127134002714	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1127134002715	Patatin-like phospholipase; Region: Patatin; pfam01734
1127134002716	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1127134002717	short chain dehydrogenase; Provisional; Region: PRK07825
1127134002718	classical (c) SDRs; Region: SDR_c; cd05233
1127134002719	NAD(P) binding site [chemical binding]; other site
1127134002720	active site
1127134002721	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
1127134002722	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134002723	tetrameric interface [polypeptide binding]; other site
1127134002724	NAD binding site [chemical binding]; other site
1127134002725	catalytic residues [active]
1127134002726	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1127134002727	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1127134002728	AsnC family; Region: AsnC_trans_reg; pfam01037
1127134002729	L-lysine aminotransferase; Provisional; Region: PRK08297
1127134002730	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134002731	inhibitor-cofactor binding pocket; inhibition site
1127134002732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134002733	catalytic residue [active]
1127134002734	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1127134002735	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1127134002736	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
1127134002737	active site
1127134002738	nucleophile elbow; other site
1127134002739	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1127134002740	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134002741	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1127134002742	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1127134002743	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134002744	carboxyltransferase (CT) interaction site; other site
1127134002745	biotinylation site [posttranslational modification]; other site
1127134002746	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1127134002747	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1127134002748	active site residue [active]
1127134002749	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1127134002750	active site residue [active]
1127134002751	Predicted transcriptional regulator [Transcription]; Region: COG2345
1127134002752	Helix-turn-helix domain; Region: HTH_20; pfam12840
1127134002753	putative DNA binding site [nucleotide binding]; other site
1127134002754	putative Zn2+ binding site [ion binding]; other site
1127134002755	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1127134002756	active site
1127134002757	dimer interface [polypeptide binding]; other site
1127134002758	Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822
1127134002759	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134002760	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134002761	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134002762	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1127134002763	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1127134002764	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1127134002765	Bacterial PH domain; Region: DUF304; pfam03703
1127134002766	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134002767	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134002768	active site
1127134002769	phosphorylation site [posttranslational modification]
1127134002770	intermolecular recognition site; other site
1127134002771	dimerization interface [polypeptide binding]; other site
1127134002772	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134002773	DNA binding site [nucleotide binding]
1127134002774	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134002775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134002776	dimer interface [polypeptide binding]; other site
1127134002777	phosphorylation site [posttranslational modification]
1127134002778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134002779	ATP binding site [chemical binding]; other site
1127134002780	Mg2+ binding site [ion binding]; other site
1127134002781	G-X-G motif; other site
1127134002782	Predicted membrane protein [Function unknown]; Region: COG2246
1127134002783	GtrA-like protein; Region: GtrA; pfam04138
1127134002784	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1127134002785	ATP-grasp domain; Region: ATP-grasp; pfam02222
1127134002786	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1127134002787	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002788	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134002789	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
1127134002790	FAD binding site [chemical binding]; other site
1127134002791	homotetramer interface [polypeptide binding]; other site
1127134002792	substrate binding pocket [chemical binding]; other site
1127134002793	catalytic base [active]
1127134002794	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134002795	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134002796	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134002797	Coenzyme A binding pocket [chemical binding]; other site
1127134002798	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134002799	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1127134002800	Predicted membrane protein [Function unknown]; Region: COG2246
1127134002801	GtrA-like protein; Region: GtrA; pfam04138
1127134002802	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1127134002803	conserved cys residue [active]
1127134002804	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134002805	DinB superfamily; Region: DinB_2; pfam12867
1127134002806	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1127134002807	HIT family signature motif; other site
1127134002808	catalytic residue [active]
1127134002809	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1127134002810	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1127134002811	homodimer interface [polypeptide binding]; other site
1127134002812	ligand binding site [chemical binding]; other site
1127134002813	NAD(P) binding site [chemical binding]; other site
1127134002814	trimer interface B [polypeptide binding]; other site
1127134002815	trimer interface A [polypeptide binding]; other site
1127134002816	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1127134002817	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1127134002818	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1127134002819	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1127134002820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134002821	Walker A motif; other site
1127134002822	ATP binding site [chemical binding]; other site
1127134002823	Walker B motif; other site
1127134002824	arginine finger; other site
1127134002825	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134002826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1127134002827	Cupin; Region: Cupin_6; pfam12852
1127134002828	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134002829	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134002830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134002831	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1127134002832	active site
1127134002833	classical (c) SDRs; Region: SDR_c; cd05233
1127134002834	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1127134002835	NAD(P) binding site [chemical binding]; other site
1127134002836	active site
1127134002837	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1127134002838	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1127134002839	dimerization interface [polypeptide binding]; other site
1127134002840	putative DNA binding site [nucleotide binding]; other site
1127134002841	putative Zn2+ binding site [ion binding]; other site
1127134002842	AsnC family; Region: AsnC_trans_reg; pfam01037
1127134002843	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1127134002844	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1127134002845	TPP-binding site [chemical binding]; other site
1127134002846	tetramer interface [polypeptide binding]; other site
1127134002847	heterodimer interface [polypeptide binding]; other site
1127134002848	phosphorylation loop region [posttranslational modification]
1127134002849	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1127134002850	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1127134002851	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1127134002852	alpha subunit interface [polypeptide binding]; other site
1127134002853	TPP binding site [chemical binding]; other site
1127134002854	heterodimer interface [polypeptide binding]; other site
1127134002855	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1127134002856	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1127134002857	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1127134002858	E3 interaction surface; other site
1127134002859	lipoyl attachment site [posttranslational modification]; other site
1127134002860	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1127134002861	Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135
1127134002862	benzoate transporter; Region: benE; TIGR00843
1127134002863	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1127134002864	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1127134002865	active site residue [active]
1127134002866	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1127134002867	active site residue [active]
1127134002868	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1127134002869	SNF2 Helicase protein; Region: DUF3670; pfam12419
1127134002870	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1127134002871	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134002872	ATP binding site [chemical binding]; other site
1127134002873	putative Mg++ binding site [ion binding]; other site
1127134002874	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134002875	nucleotide binding region [chemical binding]; other site
1127134002876	ATP-binding site [chemical binding]; other site
1127134002877	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1127134002878	SWIM zinc finger; Region: SWIM; pfam04434
1127134002879	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1127134002880	Amidohydrolase; Region: Amidohydro_2; pfam04909
1127134002881	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134002882	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134002883	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1127134002884	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
1127134002885	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1127134002886	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1127134002887	tetrameric interface [polypeptide binding]; other site
1127134002888	NAD binding site [chemical binding]; other site
1127134002889	catalytic residues [active]
1127134002890	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134002891	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134002892	active site
1127134002893	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1127134002894	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134002895	substrate binding site [chemical binding]; other site
1127134002896	oxyanion hole (OAH) forming residues; other site
1127134002897	trimer interface [polypeptide binding]; other site
1127134002898	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1127134002899	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1127134002900	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134002901	enoyl-CoA hydratase; Provisional; Region: PRK05862
1127134002902	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134002903	substrate binding site [chemical binding]; other site
1127134002904	oxyanion hole (OAH) forming residues; other site
1127134002905	trimer interface [polypeptide binding]; other site
1127134002906	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134002907	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134002908	MarR family; Region: MarR; pfam01047
1127134002909	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
1127134002910	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1127134002911	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1127134002912	active site
1127134002913	metal binding site [ion binding]; metal-binding site
1127134002914	SnoaL-like domain; Region: SnoaL_4; cl17707
1127134002915	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1127134002916	Protein of unknown function (DUF3105); Region: DUF3105; pfam11303
1127134002917	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1127134002918	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1127134002919	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1127134002920	active site
1127134002921	HIGH motif; other site
1127134002922	KMSK motif region; other site
1127134002923	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1127134002924	tRNA binding surface [nucleotide binding]; other site
1127134002925	anticodon binding site; other site
1127134002926	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1127134002927	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1127134002928	active site
1127134002929	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134002930	substrate binding site [chemical binding]; other site
1127134002931	catalytic residues [active]
1127134002932	dimer interface [polypeptide binding]; other site
1127134002933	homoserine dehydrogenase; Provisional; Region: PRK06349
1127134002934	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1127134002935	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1127134002936	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1127134002937	threonine synthase; Reviewed; Region: PRK06721
1127134002938	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1127134002939	homodimer interface [polypeptide binding]; other site
1127134002940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134002941	catalytic residue [active]
1127134002942	homoserine kinase; Provisional; Region: PRK01212
1127134002943	transcription termination factor Rho; Provisional; Region: PRK12608
1127134002944	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1127134002945	RNA binding site [nucleotide binding]; other site
1127134002946	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1127134002947	multimer interface [polypeptide binding]; other site
1127134002948	Walker A motif; other site
1127134002949	ATP binding site [chemical binding]; other site
1127134002950	Walker B motif; other site
1127134002951	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
1127134002952	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1127134002953	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1127134002954	RF-1 domain; Region: RF-1; pfam00472
1127134002955	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1127134002956	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134002957	S-adenosylmethionine binding site [chemical binding]; other site
1127134002958	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1127134002959	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1127134002960	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1127134002961	Mg++ binding site [ion binding]; other site
1127134002962	putative catalytic motif [active]
1127134002963	substrate binding site [chemical binding]; other site
1127134002964	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1127134002965	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1127134002966	F0F1 ATP synthase subunit C; Validated; Region: PRK07874
1127134002967	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1127134002968	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1127134002969	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
1127134002970	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1127134002971	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1127134002972	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1127134002973	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1127134002974	beta subunit interaction interface [polypeptide binding]; other site
1127134002975	Walker A motif; other site
1127134002976	ATP binding site [chemical binding]; other site
1127134002977	Walker B motif; other site
1127134002978	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1127134002979	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1127134002980	core domain interface [polypeptide binding]; other site
1127134002981	delta subunit interface [polypeptide binding]; other site
1127134002982	epsilon subunit interface [polypeptide binding]; other site
1127134002983	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1127134002984	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1127134002985	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1127134002986	alpha subunit interaction interface [polypeptide binding]; other site
1127134002987	Walker A motif; other site
1127134002988	ATP binding site [chemical binding]; other site
1127134002989	Walker B motif; other site
1127134002990	inhibitor binding site; inhibition site
1127134002991	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1127134002992	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1127134002993	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1127134002994	gamma subunit interface [polypeptide binding]; other site
1127134002995	epsilon subunit interface [polypeptide binding]; other site
1127134002996	LBP interface [polypeptide binding]; other site
1127134002997	Protein of unknown function (DUF2550); Region: DUF2550; pfam10739
1127134002998	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1127134002999	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1127134003000	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1127134003001	hinge; other site
1127134003002	active site
1127134003003	hypothetical protein; Provisional; Region: PRK03298
1127134003004	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
1127134003005	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134003006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003007	non-specific DNA binding site [nucleotide binding]; other site
1127134003008	salt bridge; other site
1127134003009	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003010	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
1127134003011	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134003012	putative NAD(P) binding site [chemical binding]; other site
1127134003013	major vault protein; Provisional; Region: PTZ00491
1127134003014	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1127134003015	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134003016	dimer interface [polypeptide binding]; other site
1127134003017	substrate binding site [chemical binding]; other site
1127134003018	metal binding site [ion binding]; metal-binding site
1127134003019	putative acyltransferase; Provisional; Region: PRK05790
1127134003020	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134003021	dimer interface [polypeptide binding]; other site
1127134003022	active site
1127134003023	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1127134003024	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1127134003025	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
1127134003026	glycogen branching enzyme; Provisional; Region: PRK05402
1127134003027	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1127134003028	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1127134003029	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1127134003030	active site
1127134003031	catalytic site [active]
1127134003032	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1127134003033	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
1127134003034	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1127134003035	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1127134003036	active site
1127134003037	catalytic site [active]
1127134003038	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1127134003039	putative homodimer interface [polypeptide binding]; other site
1127134003040	putative active site pocket [active]
1127134003041	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1127134003042	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1127134003043	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134003044	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134003045	active site
1127134003046	ATP binding site [chemical binding]; other site
1127134003047	substrate binding site [chemical binding]; other site
1127134003048	activation loop (A-loop); other site
1127134003049	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1127134003050	homotrimer interaction site [polypeptide binding]; other site
1127134003051	putative active site [active]
1127134003052	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003053	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003054	salt bridge; other site
1127134003055	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1127134003056	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134003057	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1127134003058	DEAD/DEAH box helicase; Region: DEAD; pfam00270
1127134003059	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1127134003060	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1127134003061	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1127134003062	Isochorismatase family; Region: Isochorismatase; pfam00857
1127134003063	catalytic triad [active]
1127134003064	metal binding site [ion binding]; metal-binding site
1127134003065	conserved cis-peptide bond; other site
1127134003066	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1127134003067	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1127134003068	active site
1127134003069	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1127134003070	Domain of unknown function (DUF2017); Region: DUF2017; pfam09438
1127134003071	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1127134003072	putative active site pocket [active]
1127134003073	cleavage site
1127134003074	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1127134003075	MPN+ (JAMM) motif; other site
1127134003076	Zinc-binding site [ion binding]; other site
1127134003077	Ubiquitin-like proteins; Region: UBQ; cl00155
1127134003078	charged pocket; other site
1127134003079	hydrophobic patch; other site
1127134003080	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1127134003081	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1127134003082	dimer interface [polypeptide binding]; other site
1127134003083	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134003084	catalytic residue [active]
1127134003085	Rhomboid family; Region: Rhomboid; pfam01694
1127134003086	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
1127134003087	ribonuclease PH; Reviewed; Region: rph; PRK00173
1127134003088	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1127134003089	hexamer interface [polypeptide binding]; other site
1127134003090	active site
1127134003091	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1127134003092	active site
1127134003093	dimerization interface [polypeptide binding]; other site
1127134003094	Glucitol operon activator protein (GutM); Region: GutM; cl01890
1127134003095	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1127134003096	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134003097	short chain dehydrogenase; Provisional; Region: PRK06197
1127134003098	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1127134003099	putative NAD(P) binding site [chemical binding]; other site
1127134003100	active site
1127134003101	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134003102	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003103	non-specific DNA binding site [nucleotide binding]; other site
1127134003104	salt bridge; other site
1127134003105	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003106	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134003107	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1127134003108	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1127134003109	active site
1127134003110	EspG family; Region: ESX-1_EspG; pfam14011
1127134003111	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134003112	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134003113	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134003114	DNA binding residues [nucleotide binding]
1127134003115	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134003116	Ecdysteroid kinase; Region: EcKinase; cl17738
1127134003117	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134003118	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1127134003119	Lysine efflux permease [General function prediction only]; Region: COG1279
1127134003120	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1127134003121	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134003122	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134003123	dimerization interface [polypeptide binding]; other site
1127134003124	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
1127134003125	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134003126	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1127134003127	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134003128	DNA binding residues [nucleotide binding]
1127134003129	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1127134003130	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134003131	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134003132	putative substrate translocation pore; other site
1127134003133	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134003134	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134003135	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1127134003136	hypothetical protein; Provisional; Region: PRK06847
1127134003137	hypothetical protein; Provisional; Region: PRK07236
1127134003138	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1127134003139	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320
1127134003140	gating phenylalanine in ion channel; other site
1127134003141	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134003142	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134003143	dimerization interface [polypeptide binding]; other site
1127134003144	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1127134003145	PhoU domain; Region: PhoU; pfam01895
1127134003146	Permease; Region: Permease; pfam02405
1127134003147	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134003148	hypothetical protein; Region: PHA00727
1127134003149	Permease; Region: Permease; pfam02405
1127134003150	mce related protein; Region: MCE; pfam02470
1127134003151	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1127134003152	mce related protein; Region: MCE; pfam02470
1127134003153	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003154	mce related protein; Region: MCE; pfam02470
1127134003155	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003156	mce related protein; Region: MCE; pfam02470
1127134003157	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003158	mce related protein; Region: MCE; pfam02470
1127134003159	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003160	mce related protein; Region: MCE; pfam02470
1127134003161	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1127134003162	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134003163	putative DNA binding site [nucleotide binding]; other site
1127134003164	putative Zn2+ binding site [ion binding]; other site
1127134003165	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003166	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003167	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134003168	hydrophobic ligand binding site; other site
1127134003169	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003170	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003171	mce related protein; Region: MCE; pfam02470
1127134003172	mce related protein; Region: MCE; pfam02470
1127134003173	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1127134003174	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003175	mce related protein; Region: MCE; pfam02470
1127134003176	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003177	mce related protein; Region: MCE; pfam02470
1127134003178	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003179	mce related protein; Region: MCE; pfam02470
1127134003180	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134003181	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134003182	Permease; Region: Permease; pfam02405
1127134003183	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134003184	Permease; Region: Permease; pfam02405
1127134003185	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1127134003186	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134003187	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134003188	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134003189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134003190	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
1127134003191	PAS domain S-box; Region: sensory_box; TIGR00229
1127134003192	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1127134003193	putative active site [active]
1127134003194	heme pocket [chemical binding]; other site
1127134003195	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1127134003196	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1127134003197	metal binding site [ion binding]; metal-binding site
1127134003198	active site
1127134003199	I-site; other site
1127134003200	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1127134003201	short chain dehydrogenase; Provisional; Region: PRK06914
1127134003202	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1127134003203	NADP binding site [chemical binding]; other site
1127134003204	active site
1127134003205	steroid binding site; other site
1127134003206	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1127134003207	Predicted transcriptional regulator [Transcription]; Region: COG1959
1127134003208	Transcriptional regulator; Region: Rrf2; pfam02082
1127134003209	Protein of unknown function DUF72; Region: DUF72; pfam01904
1127134003210	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1127134003211	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1127134003212	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1127134003213	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134003214	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1127134003215	ABC1 family; Region: ABC1; pfam03109
1127134003216	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1127134003217	active site
1127134003218	ATP binding site [chemical binding]; other site
1127134003219	substrate binding site [chemical binding]; other site
1127134003220	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003221	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003222	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134003223	Secretory lipase; Region: LIP; pfam03583
1127134003224	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134003225	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003226	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003227	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1127134003228	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134003229	FAD binding domain; Region: FAD_binding_2; pfam00890
1127134003230	hydrophobic ligand binding site; other site
1127134003231	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134003232	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134003233	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1127134003234	NAD(P) binding site [chemical binding]; other site
1127134003235	active site
1127134003236	AAA domain; Region: AAA_21; pfam13304
1127134003237	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1127134003238	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
1127134003239	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
1127134003240	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134003241	active site 2 [active]
1127134003242	active site 1 [active]
1127134003243	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1127134003244	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1127134003245	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
1127134003246	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
1127134003247	putative NAD(P) binding site [chemical binding]; other site
1127134003248	active site
1127134003249	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
1127134003250	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1127134003251	active site
1127134003252	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1127134003253	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003254	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003255	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
1127134003256	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134003257	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134003258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134003259	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134003260	Walker A/P-loop; other site
1127134003261	ATP binding site [chemical binding]; other site
1127134003262	Q-loop/lid; other site
1127134003263	ABC transporter signature motif; other site
1127134003264	Walker B; other site
1127134003265	D-loop; other site
1127134003266	H-loop/switch region; other site
1127134003267	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003268	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134003269	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1127134003270	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1127134003271	catalytic triad [active]
1127134003272	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
1127134003273	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1127134003274	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1127134003275	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134003276	MarR family; Region: MarR_2; pfam12802
1127134003277	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134003278	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134003279	catalytic residue [active]
1127134003280	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1127134003281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1127134003282	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1127134003283	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1127134003284	amino acid transporter; Region: 2A0306; TIGR00909
1127134003285	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1127134003286	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1127134003287	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
1127134003288	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1127134003289	NAD binding site [chemical binding]; other site
1127134003290	Phe binding site; other site
1127134003291	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
1127134003292	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1127134003293	dimer interface [polypeptide binding]; other site
1127134003294	PYR/PP interface [polypeptide binding]; other site
1127134003295	TPP binding site [chemical binding]; other site
1127134003296	substrate binding site [chemical binding]; other site
1127134003297	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1127134003298	TPP-binding site [chemical binding]; other site
1127134003299	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
1127134003300	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1127134003301	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1127134003302	AsnC family; Region: AsnC_trans_reg; pfam01037
1127134003303	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
1127134003304	putative active site [active]
1127134003305	putative substrate binding site [chemical binding]; other site
1127134003306	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1127134003307	dimer interface [polypeptide binding]; other site
1127134003308	catalytic site [active]
1127134003309	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1127134003310	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1127134003311	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134003312	NAD(P) binding site [chemical binding]; other site
1127134003313	active site
1127134003314	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1127134003315	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1127134003316	active site
1127134003317	FMN binding site [chemical binding]; other site
1127134003318	2,4-decadienoyl-CoA binding site; other site
1127134003319	catalytic residue [active]
1127134003320	4Fe-4S cluster binding site [ion binding]; other site
1127134003321	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1127134003322	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134003323	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134003324	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1127134003325	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1127134003326	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
1127134003327	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134003328	putative substrate translocation pore; other site
1127134003329	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
1127134003330	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003331	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1127134003332	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1127134003333	FAD binding pocket [chemical binding]; other site
1127134003334	FAD binding motif [chemical binding]; other site
1127134003335	phosphate binding motif [ion binding]; other site
1127134003336	beta-alpha-beta structure motif; other site
1127134003337	NAD binding pocket [chemical binding]; other site
1127134003338	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134003339	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1127134003340	catalytic loop [active]
1127134003341	iron binding site [ion binding]; other site
1127134003342	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1127134003343	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1127134003344	putative di-iron ligands [ion binding]; other site
1127134003345	Foamy virus envelope protein; Region: Foamy_virus_ENV; pfam03408
1127134003346	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
1127134003347	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1127134003348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134003349	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1127134003350	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1127134003351	dimer interface [polypeptide binding]; other site
1127134003352	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134003353	catalytic residue [active]
1127134003354	Excalibur calcium-binding domain; Region: Excalibur; smart00894
1127134003355	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1127134003356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134003357	Walker A/P-loop; other site
1127134003358	ATP binding site [chemical binding]; other site
1127134003359	Q-loop/lid; other site
1127134003360	ABC transporter signature motif; other site
1127134003361	Walker B; other site
1127134003362	D-loop; other site
1127134003363	H-loop/switch region; other site
1127134003364	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1127134003365	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1127134003366	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134003367	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134003368	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134003369	dimerization interface [polypeptide binding]; other site
1127134003370	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134003371	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1127134003372	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1127134003373	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1127134003374	tetrameric interface [polypeptide binding]; other site
1127134003375	NAD binding site [chemical binding]; other site
1127134003376	catalytic residues [active]
1127134003377	Predicted permeases [General function prediction only]; Region: COG0730
1127134003378	Copper resistance protein D; Region: CopD; cl00563
1127134003379	Copper resistance protein D; Region: CopD; pfam05425
1127134003380	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
1127134003381	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1127134003382	threonine dehydratase; Provisional; Region: PRK08246
1127134003383	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134003384	catalytic residue [active]
1127134003385	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1127134003386	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1127134003387	dimer interface [polypeptide binding]; other site
1127134003388	ssDNA binding site [nucleotide binding]; other site
1127134003389	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1127134003390	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1127134003391	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134003392	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134003393	ABC transporter; Region: ABC_tran_2; pfam12848
1127134003394	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134003395	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1127134003396	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1127134003397	active site
1127134003398	AzlC protein; Region: AzlC; pfam03591
1127134003399	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134003400	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003401	non-specific DNA binding site [nucleotide binding]; other site
1127134003402	salt bridge; other site
1127134003403	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003404	Cupin domain; Region: Cupin_2; cl17218
1127134003405	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1127134003406	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1127134003407	active site
1127134003408	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1127134003409	apolar tunnel; other site
1127134003410	heme binding site [chemical binding]; other site
1127134003411	dimerization interface [polypeptide binding]; other site
1127134003412	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
1127134003413	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1127134003414	active site
1127134003415	catalytic site [active]
1127134003416	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1127134003417	Repair protein; Region: Repair_PSII; pfam04536
1127134003418	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134003419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003420	non-specific DNA binding site [nucleotide binding]; other site
1127134003421	salt bridge; other site
1127134003422	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003423	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1127134003424	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1127134003425	oligomer interface [polypeptide binding]; other site
1127134003426	active site residues [active]
1127134003427	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1127134003428	oligomer interface [polypeptide binding]; other site
1127134003429	Clp protease; Region: CLP_protease; pfam00574
1127134003430	active site residues [active]
1127134003431	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
1127134003432	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
1127134003433	Zn binding site [ion binding]; other site
1127134003434	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1127134003435	ATP binding site [chemical binding]; other site
1127134003436	active site
1127134003437	substrate binding site [chemical binding]; other site
1127134003438	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134003439	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134003440	DNA binding residues [nucleotide binding]
1127134003441	YCII-related domain; Region: YCII; cl00999
1127134003442	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1127134003443	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134003444	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134003445	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1127134003446	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1127134003447	catalytic residues [active]
1127134003448	Peptidase family M48; Region: Peptidase_M48; pfam01435
1127134003449	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1127134003450	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1127134003451	N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970
1127134003452	putative DNA binding site [nucleotide binding]; other site
1127134003453	catalytic residue [active]
1127134003454	putative H2TH interface [polypeptide binding]; other site
1127134003455	putative catalytic residues [active]
1127134003456	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1127134003457	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1127134003458	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1127134003459	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1127134003460	metal binding site [ion binding]; metal-binding site
1127134003461	active site
1127134003462	I-site; other site
1127134003463	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134003464	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134003465	DNA binding residues [nucleotide binding]
1127134003466	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1127134003467	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134003468	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1127134003469	AAA-like domain; Region: AAA_10; pfam12846
1127134003470	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134003471	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134003472	catalytic residue [active]
1127134003473	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134003474	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134003475	catalytic residue [active]
1127134003476	PPE family; Region: PPE; pfam00823
1127134003477	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1127134003478	NlpC/P60 family; Region: NLPC_P60; cl17555
1127134003479	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134003480	type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922
1127134003481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134003482	Walker A motif; other site
1127134003483	ATP binding site [chemical binding]; other site
1127134003484	Walker B motif; other site
1127134003485	arginine finger; other site
1127134003486	type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919
1127134003487	type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924
1127134003488	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134003489	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1127134003490	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134003491	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134003492	PPE family; Region: PPE; pfam00823
1127134003493	EspG family; Region: ESX-1_EspG; pfam14011
1127134003494	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1127134003495	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
1127134003496	type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921
1127134003497	Subtilase family; Region: Peptidase_S8; pfam00082
1127134003498	active site
1127134003499	catalytic residues [active]
1127134003500	type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923
1127134003501	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003502	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003503	salt bridge; other site
1127134003504	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
1127134003505	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
1127134003506	Membrane protease subunit, stomatin/prohibitin family [Amino acid    transport and metabolism]; Region: COG4260
1127134003507	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1127134003508	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1127134003509	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1127134003510	L-asparagine permease; Provisional; Region: PRK15049
1127134003511	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134003512	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134003513	active site
1127134003514	ATP binding site [chemical binding]; other site
1127134003515	substrate binding site [chemical binding]; other site
1127134003516	activation loop (A-loop); other site
1127134003517	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134003518	Transcription factor WhiB; Region: Whib; pfam02467
1127134003519	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134003520	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134003521	DNA binding residues [nucleotide binding]
1127134003522	RibD C-terminal domain; Region: RibD_C; cl17279
1127134003523	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134003524	Predicted ATPase [General function prediction only]; Region: COG3903
1127134003525	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1127134003526	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134003527	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134003528	putative phosphoketolase; Provisional; Region: PRK05261
1127134003529	XFP N-terminal domain; Region: XFP_N; pfam09364
1127134003530	XFP C-terminal domain; Region: XFP_C; pfam09363
1127134003531	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1127134003532	trigger factor; Provisional; Region: tig; PRK01490
1127134003533	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1127134003534	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1127134003535	Clp protease; Region: CLP_protease; pfam00574
1127134003536	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1127134003537	oligomer interface [polypeptide binding]; other site
1127134003538	active site residues [active]
1127134003539	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
1127134003540	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1127134003541	oligomer interface [polypeptide binding]; other site
1127134003542	active site residues [active]
1127134003543	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1127134003544	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1127134003545	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134003546	Walker A motif; other site
1127134003547	ATP binding site [chemical binding]; other site
1127134003548	Walker B motif; other site
1127134003549	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1127134003550	aminoacyl-tRNA ligase; Region: PLN02882
1127134003551	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1127134003552	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1127134003553	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1127134003554	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1127134003555	putative molybdopterin cofactor binding site [chemical binding]; other site
1127134003556	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1127134003557	putative molybdopterin cofactor binding site; other site
1127134003558	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134003559	phosphopeptide binding site; other site
1127134003560	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1127134003561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134003562	Coenzyme A binding pocket [chemical binding]; other site
1127134003563	glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369
1127134003564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003566	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134003567	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134003568	diacylglycerol kinase; Reviewed; Region: PRK11914
1127134003569	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1127134003570	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1127134003571	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134003572	active site
1127134003573	HIGH motif; other site
1127134003574	nucleotide binding site [chemical binding]; other site
1127134003575	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1127134003576	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1127134003577	active site
1127134003578	KMSKS motif; other site
1127134003579	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1127134003580	tRNA binding surface [nucleotide binding]; other site
1127134003581	anticodon binding site; other site
1127134003582	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1127134003583	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1127134003584	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1127134003585	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1127134003586	Protein of unknown function (DUF4233); Region: DUF4233; pfam14017
1127134003587	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1127134003588	active site
1127134003589	multimer interface [polypeptide binding]; other site
1127134003590	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1127134003591	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1127134003592	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1127134003593	homodimer interface [polypeptide binding]; other site
1127134003594	oligonucleotide binding site [chemical binding]; other site
1127134003595	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1127134003596	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1127134003597	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1127134003598	GTPase CgtA; Reviewed; Region: obgE; PRK12296
1127134003599	GTP1/OBG; Region: GTP1_OBG; pfam01018
1127134003600	Obg GTPase; Region: Obg; cd01898
1127134003601	G1 box; other site
1127134003602	GTP/Mg2+ binding site [chemical binding]; other site
1127134003603	Switch I region; other site
1127134003604	G2 box; other site
1127134003605	G3 box; other site
1127134003606	Switch II region; other site
1127134003607	G4 box; other site
1127134003608	G5 box; other site
1127134003609	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1127134003610	gamma-glutamyl kinase; Provisional; Region: PRK05429
1127134003611	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1127134003612	nucleotide binding site [chemical binding]; other site
1127134003613	homotetrameric interface [polypeptide binding]; other site
1127134003614	putative phosphate binding site [ion binding]; other site
1127134003615	putative allosteric binding site; other site
1127134003616	PUA domain; Region: PUA; pfam01472
1127134003617	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1127134003618	putative active site [active]
1127134003619	EspG family; Region: ESX-1_EspG; pfam14011
1127134003620	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1127134003621	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1127134003622	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1127134003623	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134003624	acyl-CoA synthetase; Validated; Region: PRK09192
1127134003625	acyl-activating enzyme (AAE) consensus motif; other site
1127134003626	AMP binding site [chemical binding]; other site
1127134003627	active site
1127134003628	CoA binding site [chemical binding]; other site
1127134003629	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1127134003630	active site
1127134003631	NTP binding site [chemical binding]; other site
1127134003632	metal binding triad [ion binding]; metal-binding site
1127134003633	antibiotic binding site [chemical binding]; other site
1127134003634	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1127134003635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134003636	NAD(P) binding site [chemical binding]; other site
1127134003637	active site
1127134003638	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
1127134003639	active site
1127134003640	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
1127134003641	A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756
1127134003642	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1127134003643	FMN binding site [chemical binding]; other site
1127134003644	dimer interface [polypeptide binding]; other site
1127134003645	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
1127134003646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134003647	S-adenosylmethionine binding site [chemical binding]; other site
1127134003648	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134003649	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134003650	DNA binding residues [nucleotide binding]
1127134003651	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_2; cd12159
1127134003652	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1127134003653	putative ligand binding site [chemical binding]; other site
1127134003654	putative NAD binding site [chemical binding]; other site
1127134003655	catalytic site [active]
1127134003656	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
1127134003657	nucleotide binding site [chemical binding]; other site
1127134003658	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1127134003659	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134003660	ATP binding site [chemical binding]; other site
1127134003661	putative Mg++ binding site [ion binding]; other site
1127134003662	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134003663	nucleotide binding region [chemical binding]; other site
1127134003664	ATP-binding site [chemical binding]; other site
1127134003665	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1127134003666	hypothetical protein; Reviewed; Region: PRK09588
1127134003667	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1127134003668	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1127134003669	substrate binding site [chemical binding]; other site
1127134003670	dimer interface [polypeptide binding]; other site
1127134003671	ATP binding site [chemical binding]; other site
1127134003672	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1127134003673	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1127134003674	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1127134003675	putative catalytic cysteine [active]
1127134003676	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1127134003677	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134003678	Walker A motif; other site
1127134003679	ATP binding site [chemical binding]; other site
1127134003680	Walker B motif; other site
1127134003681	arginine finger; other site
1127134003682	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1127134003683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1127134003684	HSP90 family protein; Provisional; Region: PRK14083
1127134003685	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134003686	ATP binding site [chemical binding]; other site
1127134003687	Mg2+ binding site [ion binding]; other site
1127134003688	G-X-G motif; other site
1127134003689	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134003690	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1127134003691	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1127134003692	active site
1127134003693	(T/H)XGH motif; other site
1127134003694	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1127134003695	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134003696	catalytic core [active]
1127134003697	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1127134003698	active site
1127134003699	catalytic triad [active]
1127134003700	oxyanion hole [active]
1127134003701	EDD domain protein, DegV family; Region: DegV; TIGR00762
1127134003702	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1127134003703	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1127134003704	Helix-hairpin-helix motif; Region: HHH; pfam00633
1127134003705	Competence protein; Region: Competence; pfam03772
1127134003706	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1127134003707	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134003708	hypothetical protein; Reviewed; Region: PRK07914
1127134003709	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
1127134003710	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134003711	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134003712	active site
1127134003713	catalytic tetrad [active]
1127134003714	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134003715	non-specific DNA binding site [nucleotide binding]; other site
1127134003716	salt bridge; other site
1127134003717	sequence-specific DNA binding site [nucleotide binding]; other site
1127134003718	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1127134003719	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1127134003720	amphipathic channel; other site
1127134003721	Asn-Pro-Ala signature motifs; other site
1127134003722	PemK-like protein; Region: PemK; pfam02452
1127134003723	GTP-binding protein LepA; Provisional; Region: PRK05433
1127134003724	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1127134003725	G1 box; other site
1127134003726	putative GEF interaction site [polypeptide binding]; other site
1127134003727	GTP/Mg2+ binding site [chemical binding]; other site
1127134003728	Switch I region; other site
1127134003729	G2 box; other site
1127134003730	G3 box; other site
1127134003731	Switch II region; other site
1127134003732	G4 box; other site
1127134003733	G5 box; other site
1127134003734	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1127134003735	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1127134003736	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1127134003737	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1127134003738	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1127134003739	Dynamin family; Region: Dynamin_N; pfam00350
1127134003740	G1 box; other site
1127134003741	GTP/Mg2+ binding site [chemical binding]; other site
1127134003742	Switch I region; other site
1127134003743	G3 box; other site
1127134003744	Switch II region; other site
1127134003745	G4 box; other site
1127134003746	G5 box; other site
1127134003747	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1127134003748	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1127134003749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134003750	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1127134003751	S-adenosylmethionine binding site [chemical binding]; other site
1127134003752	Peptidase family M48; Region: Peptidase_M48; pfam01435
1127134003753	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1127134003754	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1127134003755	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1127134003756	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134003757	dimer interface [polypeptide binding]; other site
1127134003758	conserved gate region; other site
1127134003759	putative PBP binding loops; other site
1127134003760	ABC-ATPase subunit interface; other site
1127134003761	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1127134003762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134003763	dimer interface [polypeptide binding]; other site
1127134003764	conserved gate region; other site
1127134003765	putative PBP binding loops; other site
1127134003766	ABC-ATPase subunit interface; other site
1127134003767	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1127134003768	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1127134003769	Walker A/P-loop; other site
1127134003770	ATP binding site [chemical binding]; other site
1127134003771	Q-loop/lid; other site
1127134003772	ABC transporter signature motif; other site
1127134003773	Walker B; other site
1127134003774	D-loop; other site
1127134003775	H-loop/switch region; other site
1127134003776	TOBE domain; Region: TOBE; pfam03459
1127134003777	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134003778	nucleotide binding site [chemical binding]; other site
1127134003779	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1127134003780	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
1127134003781	4Fe-4S binding domain; Region: Fer4; pfam00037
1127134003782	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
1127134003783	ferredoxin-NADP+ reductase; Region: PLN02852
1127134003784	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134003785	short chain dehydrogenase; Provisional; Region: PRK07478
1127134003786	classical (c) SDRs; Region: SDR_c; cd05233
1127134003787	NAD(P) binding site [chemical binding]; other site
1127134003788	active site
1127134003789	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134003790	nucleotide binding site [chemical binding]; other site
1127134003791	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1127134003792	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134003793	acyl-activating enzyme (AAE) consensus motif; other site
1127134003794	AMP binding site [chemical binding]; other site
1127134003795	active site
1127134003796	CoA binding site [chemical binding]; other site
1127134003797	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
1127134003798	active site
1127134003799	substrate binding pocket [chemical binding]; other site
1127134003800	homodimer interaction site [polypeptide binding]; other site
1127134003801	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1127134003802	DNA-binding interface [nucleotide binding]; DNA binding site
1127134003803	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1127134003804	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134003805	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1127134003806	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134003807	active site
1127134003808	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134003809	HTH domain; Region: HTH_11; pfam08279
1127134003810	WYL domain; Region: WYL; pfam13280
1127134003811	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1127134003812	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1127134003813	putative active site [active]
1127134003814	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1127134003815	active site
1127134003816	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
1127134003817	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1127134003818	CysD dimerization site [polypeptide binding]; other site
1127134003819	G1 box; other site
1127134003820	putative GEF interaction site [polypeptide binding]; other site
1127134003821	GTP/Mg2+ binding site [chemical binding]; other site
1127134003822	Switch I region; other site
1127134003823	G2 box; other site
1127134003824	G3 box; other site
1127134003825	Switch II region; other site
1127134003826	G4 box; other site
1127134003827	G5 box; other site
1127134003828	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1127134003829	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1127134003830	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1127134003831	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1127134003832	Active Sites [active]
1127134003833	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1127134003834	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1127134003835	Active Sites [active]
1127134003836	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1127134003837	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1127134003838	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1127134003839	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1127134003840	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1127134003841	RNA methyltransferase, RsmE family; Region: TIGR00046
1127134003842	chaperone protein DnaJ; Provisional; Region: PRK14278
1127134003843	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1127134003844	HSP70 interaction site [polypeptide binding]; other site
1127134003845	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1127134003846	Zn binding sites [ion binding]; other site
1127134003847	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1127134003848	dimer interface [polypeptide binding]; other site
1127134003849	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1127134003850	HTH domain; Region: HTH_11; cl17392
1127134003851	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
1127134003852	coproporphyrinogen III oxidase; Validated; Region: PRK05628
1127134003853	HemN C-terminal domain; Region: HemN_C; pfam06969
1127134003854	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1127134003855	PhoH-like protein; Region: PhoH; pfam02562
1127134003856	metal-binding heat shock protein; Provisional; Region: PRK00016
1127134003857	hypothetical protein; Provisional; Region: PRK11573
1127134003858	Domain of unknown function DUF21; Region: DUF21; pfam01595
1127134003859	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1127134003860	Transporter associated domain; Region: CorC_HlyC; smart01091
1127134003861	GTPase Era; Reviewed; Region: era; PRK00089
1127134003862	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1127134003863	G1 box; other site
1127134003864	GTP/Mg2+ binding site [chemical binding]; other site
1127134003865	Switch I region; other site
1127134003866	G2 box; other site
1127134003867	Switch II region; other site
1127134003868	G3 box; other site
1127134003869	G4 box; other site
1127134003870	G5 box; other site
1127134003871	KH domain; Region: KH_2; pfam07650
1127134003872	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134003873	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134003874	active site
1127134003875	ATP binding site [chemical binding]; other site
1127134003876	substrate binding site [chemical binding]; other site
1127134003877	activation loop (A-loop); other site
1127134003878	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134003879	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134003880	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134003881	active site
1127134003882	ATP binding site [chemical binding]; other site
1127134003883	substrate binding site [chemical binding]; other site
1127134003884	activation loop (A-loop); other site
1127134003885	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1127134003886	amidase; Provisional; Region: PRK06061
1127134003887	Amidase; Region: Amidase; cl11426
1127134003888	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134003889	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173
1127134003890	active site
1127134003891	ADP-ribosylating toxin turn-turn motif; other site
1127134003892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003894	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1127134003895	Recombination protein O N terminal; Region: RecO_N; pfam11967
1127134003896	Recombination protein O C terminal; Region: RecO_C; pfam02565
1127134003897	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829
1127134003898	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1127134003899	catalytic residue [active]
1127134003900	putative FPP diphosphate  binding site; other site
1127134003901	putative FPP binding hydrophobic cleft; other site
1127134003902	dimer interface [polypeptide binding]; other site
1127134003903	putative IPP diphosphate binding site; other site
1127134003904	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003905	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003906	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1127134003907	metal binding site 2 [ion binding]; metal-binding site
1127134003908	putative DNA binding helix; other site
1127134003909	metal binding site 1 [ion binding]; metal-binding site
1127134003910	dimer interface [polypeptide binding]; other site
1127134003911	structural Zn2+ binding site [ion binding]; other site
1127134003912	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134003913	dimerization interface [polypeptide binding]; other site
1127134003914	putative DNA binding site [nucleotide binding]; other site
1127134003915	putative Zn2+ binding site [ion binding]; other site
1127134003916	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1127134003917	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1127134003918	motif 1; other site
1127134003919	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1127134003920	active site
1127134003921	motif 2; other site
1127134003922	motif 3; other site
1127134003923	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1127134003924	anticodon binding site; other site
1127134003925	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1127134003926	acyltransferase PapA5; Provisional; Region: PRK09294
1127134003927	Repair protein; Region: Repair_PSII; pfam04536
1127134003928	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1127134003929	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1127134003930	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134003931	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134003932	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1127134003933	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134003934	carboxyltransferase (CT) interaction site; other site
1127134003935	biotinylation site [posttranslational modification]; other site
1127134003936	Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326
1127134003937	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134003938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134003939	dimerization interface [polypeptide binding]; other site
1127134003940	putative DNA binding site [nucleotide binding]; other site
1127134003941	putative Zn2+ binding site [ion binding]; other site
1127134003942	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
1127134003943	putative hydrophobic ligand binding site [chemical binding]; other site
1127134003944	PRC-barrel domain; Region: PRC; pfam05239
1127134003945	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
1127134003946	Secretory lipase; Region: LIP; pfam03583
1127134003947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134003948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134003949	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1127134003950	putative active site [active]
1127134003951	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007
1127134003952	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1127134003953	Zn2+ binding site [ion binding]; other site
1127134003954	Mg2+ binding site [ion binding]; other site
1127134003955	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1127134003956	DNA primase; Validated; Region: dnaG; PRK05667
1127134003957	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1127134003958	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1127134003959	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1127134003960	active site
1127134003961	metal binding site [ion binding]; metal-binding site
1127134003962	interdomain interaction site; other site
1127134003963	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1127134003964	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766
1127134003965	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1127134003966	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134003967	active site
1127134003968	DNA binding site [nucleotide binding]
1127134003969	Int/Topo IB signature motif; other site
1127134003970	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1127134003971	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134003972	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134003973	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134003974	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1127134003975	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134003976	catalytic loop [active]
1127134003977	iron binding site [ion binding]; other site
1127134003978	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134003979	Cytochrome P450; Region: p450; cl12078
1127134003980	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1127134003981	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134003982	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134003983	Permease; Region: Permease; pfam02405
1127134003984	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134003985	Permease; Region: Permease; pfam02405
1127134003986	mce related protein; Region: MCE; pfam02470
1127134003987	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003988	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134003989	mce related protein; Region: MCE; pfam02470
1127134003990	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1127134003991	mce related protein; Region: MCE; pfam02470
1127134003992	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134003993	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134003994	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134003995	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1127134003996	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134003997	short chain dehydrogenase; Provisional; Region: PRK07825
1127134003998	classical (c) SDRs; Region: SDR_c; cd05233
1127134003999	NAD(P) binding site [chemical binding]; other site
1127134004000	active site
1127134004001	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1127134004002	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1127134004003	FAD binding pocket [chemical binding]; other site
1127134004004	FAD binding motif [chemical binding]; other site
1127134004005	phosphate binding motif [ion binding]; other site
1127134004006	beta-alpha-beta structure motif; other site
1127134004007	NAD(p) ribose binding residues [chemical binding]; other site
1127134004008	NAD binding pocket [chemical binding]; other site
1127134004009	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1127134004010	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134004011	catalytic loop [active]
1127134004012	iron binding site [ion binding]; other site
1127134004013	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004014	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004015	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134004016	subunit interaction site [polypeptide binding]; other site
1127134004017	PHB binding site; other site
1127134004018	CoenzymeA binding site [chemical binding]; other site
1127134004019	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134004020	Cytochrome P450; Region: p450; cl12078
1127134004021	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
1127134004022	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1127134004023	putative active site [active]
1127134004024	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004025	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004026	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1127134004027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134004028	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134004029	Ligand Binding Site [chemical binding]; other site
1127134004030	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134004031	CoenzymeA binding site [chemical binding]; other site
1127134004032	subunit interaction site [polypeptide binding]; other site
1127134004033	PHB binding site; other site
1127134004034	Domain of unknown function DUF302; Region: DUF302; pfam03625
1127134004035	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1127134004036	putative homodimer interface [polypeptide binding]; other site
1127134004037	putative homotetramer interface [polypeptide binding]; other site
1127134004038	putative allosteric switch controlling residues; other site
1127134004039	putative metal binding site [ion binding]; other site
1127134004040	putative homodimer-homodimer interface [polypeptide binding]; other site
1127134004041	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1127134004042	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1127134004043	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1127134004044	catalytic residues [active]
1127134004045	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1127134004046	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1127134004047	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
1127134004048	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134004049	Cytochrome P450; Region: p450; cl12078
1127134004050	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
1127134004051	Prephenate dehydratase; Region: PDT; pfam00800
1127134004052	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134004053	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134004054	DNA binding site [nucleotide binding]
1127134004055	active site
1127134004056	Int/Topo IB signature motif; other site
1127134004057	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134004058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134004059	non-specific DNA binding site [nucleotide binding]; other site
1127134004060	salt bridge; other site
1127134004061	sequence-specific DNA binding site [nucleotide binding]; other site
1127134004062	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
1127134004063	nudix motif; other site
1127134004064	RNHCP domain; Region: RNHCP; pfam12647
1127134004065	RNHCP domain; Region: RNHCP; pfam12647
1127134004066	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1127134004067	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1127134004068	Fasciclin domain; Region: Fasciclin; pfam02469
1127134004069	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1127134004070	DNA photolyase; Region: DNA_photolyase; pfam00875
1127134004071	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
1127134004072	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134004073	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1127134004074	DNA binding residues [nucleotide binding]
1127134004075	B12 binding domain; Region: B12-binding_2; pfam02607
1127134004076	Transport protein; Region: actII; TIGR00833
1127134004077	Transport protein; Region: actII; TIGR00833
1127134004078	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134004079	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1127134004080	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134004081	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134004082	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134004083	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134004084	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134004085	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1127134004086	Lipase (class 2); Region: Lipase_2; pfam01674
1127134004087	acyl-CoA synthetase; Validated; Region: PRK06188
1127134004088	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134004089	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1127134004090	acyl-activating enzyme (AAE) consensus motif; other site
1127134004091	acyl-activating enzyme (AAE) consensus motif; other site
1127134004092	putative AMP binding site [chemical binding]; other site
1127134004093	putative active site [active]
1127134004094	putative CoA binding site [chemical binding]; other site
1127134004095	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004096	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004097	lipid-transfer protein; Provisional; Region: PRK08256
1127134004098	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134004099	active site
1127134004100	acetyl-CoA acetyltransferase; Provisional; Region: PRK08313
1127134004101	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134004102	active site
1127134004103	lipid-transfer protein; Provisional; Region: PRK07937
1127134004104	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134004105	active site
1127134004106	Evidence 4 : Homologs of previously reported genes of unknown function
1127134004107	Evidence 4 : Homologs of previously reported genes of unknown function
1127134004108	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
1127134004109	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134004110	NAD(P) binding site [chemical binding]; other site
1127134004111	catalytic residues [active]
1127134004112	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134004113	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1127134004114	NAD(P) binding site [chemical binding]; other site
1127134004115	active site
1127134004116	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134004117	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134004118	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1127134004119	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1127134004120	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1127134004121	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1127134004122	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1127134004123	FMN-binding pocket [chemical binding]; other site
1127134004124	flavin binding motif; other site
1127134004125	phosphate binding motif [ion binding]; other site
1127134004126	beta-alpha-beta structure motif; other site
1127134004127	NAD binding pocket [chemical binding]; other site
1127134004128	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134004129	catalytic loop [active]
1127134004130	iron binding site [ion binding]; other site
1127134004131	short chain dehydrogenase; Validated; Region: PRK05855
1127134004132	classical (c) SDRs; Region: SDR_c; cd05233
1127134004133	NAD(P) binding site [chemical binding]; other site
1127134004134	active site
1127134004135	Uncharacterized conserved protein [Function unknown]; Region: COG4278
1127134004136	Possible enoyl reductase; Region: MDR_enoyl_red; cd08244
1127134004137	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134004138	putative NAD(P) binding site [chemical binding]; other site
1127134004139	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134004140	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134004141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1127134004142	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
1127134004143	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1127134004144	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
1127134004145	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004146	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004147	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1127134004148	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1127134004149	dimer interface [polypeptide binding]; other site
1127134004150	active site
1127134004151	CoA binding pocket [chemical binding]; other site
1127134004152	Predicted membrane protein [Function unknown]; Region: COG3212
1127134004153	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1127134004154	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134004155	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134004156	active site
1127134004157	phosphorylation site [posttranslational modification]
1127134004158	intermolecular recognition site; other site
1127134004159	dimerization interface [polypeptide binding]; other site
1127134004160	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134004161	DNA binding site [nucleotide binding]
1127134004162	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134004163	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134004164	dimerization interface [polypeptide binding]; other site
1127134004165	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134004166	dimer interface [polypeptide binding]; other site
1127134004167	phosphorylation site [posttranslational modification]
1127134004168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134004169	ATP binding site [chemical binding]; other site
1127134004170	Mg2+ binding site [ion binding]; other site
1127134004171	G-X-G motif; other site
1127134004172	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1127134004173	Fatty acid desaturase; Region: FA_desaturase_2; pfam03405
1127134004174	homodimer interface [polypeptide binding]; other site
1127134004175	putative substrate binding pocket [chemical binding]; other site
1127134004176	diiron center [ion binding]; other site
1127134004177	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
1127134004178	RNA/DNA hybrid binding site [nucleotide binding]; other site
1127134004179	active site
1127134004180	YCII-related domain; Region: YCII; cl00999
1127134004181	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134004182	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134004183	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134004184	DNA binding residues [nucleotide binding]
1127134004185	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1127134004186	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134004187	DNA binding residues [nucleotide binding]
1127134004188	drug binding residues [chemical binding]; other site
1127134004189	dimer interface [polypeptide binding]; other site
1127134004190	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512
1127134004191	beta-clamp/clamp loader binding surface; other site
1127134004192	Uncharacterized conserved protein [Function unknown]; Region: COG5361
1127134004193	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
1127134004194	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
1127134004195	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004196	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1127134004197	DNA-binding interface [nucleotide binding]; DNA binding site
1127134004198	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134004199	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134004200	putative metal binding site [ion binding]; other site
1127134004201	Protein of unknown function (DUF2510); Region: DUF2510; pfam10708
1127134004202	GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations; Region: GAL4; cl00068
1127134004203	DNA binding site [nucleotide binding]
1127134004204	Zn2+ binding site [ion binding]; other site
1127134004205	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1127134004206	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1127134004207	active site
1127134004208	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1127134004209	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1127134004210	glutamine binding [chemical binding]; other site
1127134004211	catalytic triad [active]
1127134004212	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1127134004213	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1127134004214	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1127134004215	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1127134004216	putative active site [active]
1127134004217	putative substrate binding site [chemical binding]; other site
1127134004218	ATP binding site [chemical binding]; other site
1127134004219	oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989
1127134004220	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1127134004221	NAD binding site [chemical binding]; other site
1127134004222	catalytic Zn binding site [ion binding]; other site
1127134004223	substrate binding site [chemical binding]; other site
1127134004224	structural Zn binding site [ion binding]; other site
1127134004225	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134004226	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134004227	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134004228	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134004229	Protein of unknown function (DUF3145); Region: DUF3145; pfam11343
1127134004230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134004231	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1127134004232	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134004233	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134004234	DNA binding residues [nucleotide binding]
1127134004235	dimerization interface [polypeptide binding]; other site
1127134004236	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1127134004237	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1127134004238	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134004239	hydrophobic ligand binding site; other site
1127134004240	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1127134004241	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1127134004242	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
1127134004243	dimer interface [polypeptide binding]; other site
1127134004244	catalytic triad [active]
1127134004245	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
1127134004246	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
1127134004247	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
1127134004248	dimer interface [polypeptide binding]; other site
1127134004249	TPP-binding site [chemical binding]; other site
1127134004250	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1127134004251	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134004252	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1127134004253	acyl carrier protein; Provisional; Region: acpP; PRK00982
1127134004254	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1127134004255	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1127134004256	dimer interface [polypeptide binding]; other site
1127134004257	active site
1127134004258	Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039
1127134004259	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134004260	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835
1127134004261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004263	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
1127134004264	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1127134004265	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1127134004266	trimer interface [polypeptide binding]; other site
1127134004267	putative metal binding site [ion binding]; other site
1127134004268	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1127134004269	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1127134004270	hexamer interface [polypeptide binding]; other site
1127134004271	ligand binding site [chemical binding]; other site
1127134004272	putative active site [active]
1127134004273	NAD(P) binding site [chemical binding]; other site
1127134004274	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1127134004275	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134004276	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134004277	DNA binding residues [nucleotide binding]
1127134004278	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1127134004279	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1127134004280	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1127134004281	hypothetical protein; Provisional; Region: PRK07908
1127134004282	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134004283	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134004284	homodimer interface [polypeptide binding]; other site
1127134004285	catalytic residue [active]
1127134004286	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1127134004287	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1127134004288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1127134004289	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1127134004290	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1127134004291	active site
1127134004292	DNA binding site [nucleotide binding]
1127134004293	RibD C-terminal domain; Region: RibD_C; cl17279
1127134004294	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134004295	S-adenosylmethionine binding site [chemical binding]; other site
1127134004296	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134004297	active site
1127134004298	Predicted membrane protein [Function unknown]; Region: COG2246
1127134004299	GtrA-like protein; Region: GtrA; pfam04138
1127134004300	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1127134004301	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1127134004302	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134004303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134004304	active site
1127134004305	phosphorylation site [posttranslational modification]
1127134004306	intermolecular recognition site; other site
1127134004307	dimerization interface [polypeptide binding]; other site
1127134004308	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134004309	DNA binding residues [nucleotide binding]
1127134004310	dimerization interface [polypeptide binding]; other site
1127134004311	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134004312	Histidine kinase; Region: HisKA_3; pfam07730
1127134004313	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134004314	G-X-G motif; other site
1127134004315	Domain of unknown function (DUF336); Region: DUF336; pfam03928
1127134004316	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1127134004317	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
1127134004318	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134004319	Cytochrome P450; Region: p450; cl12078
1127134004320	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1127134004321	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1127134004322	homodimer interface [polypeptide binding]; other site
1127134004323	active site
1127134004324	TDP-binding site; other site
1127134004325	acceptor substrate-binding pocket; other site
1127134004326	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134004327	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134004328	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
1127134004329	Putative zinc ribbon domain; Region: DUF164; pfam02591
1127134004330	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1127134004331	RNA/DNA hybrid binding site [nucleotide binding]; other site
1127134004332	active site
1127134004333	bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238
1127134004334	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134004335	catalytic core [active]
1127134004336	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134004337	hypothetical protein; Provisional; Region: PRK06753
1127134004338	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134004339	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134004340	acyl-activating enzyme (AAE) consensus motif; other site
1127134004341	AMP binding site [chemical binding]; other site
1127134004342	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134004343	Condensation domain; Region: Condensation; pfam00668
1127134004344	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134004345	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134004346	acyl-activating enzyme (AAE) consensus motif; other site
1127134004347	AMP binding site [chemical binding]; other site
1127134004348	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134004349	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1127134004350	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
1127134004351	MPT binding site; other site
1127134004352	RibD C-terminal domain; Region: RibD_C; cl17279
1127134004353	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1127134004354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134004355	Walker A/P-loop; other site
1127134004356	ATP binding site [chemical binding]; other site
1127134004357	Q-loop/lid; other site
1127134004358	ABC transporter signature motif; other site
1127134004359	Walker B; other site
1127134004360	D-loop; other site
1127134004361	H-loop/switch region; other site
1127134004362	TOBE domain; Region: TOBE; cl01440
1127134004363	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1127134004364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134004365	putative PBP binding loops; other site
1127134004366	ABC-ATPase subunit interface; other site
1127134004367	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1127134004368	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1127134004369	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1127134004370	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134004371	DNA binding residues [nucleotide binding]
1127134004372	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1127134004373	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1127134004374	Domain of unknown function (DUF2019); Region: DUF2019; pfam09450
1127134004375	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134004376	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1127134004377	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1127134004378	Coenzyme A binding pocket [chemical binding]; other site
1127134004379	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1127134004380	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134004381	NAD(P) binding site [chemical binding]; other site
1127134004382	active site
1127134004383	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1127134004384	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1127134004385	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134004386	S-adenosylmethionine binding site [chemical binding]; other site
1127134004387	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134004388	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1127134004389	DNA binding residues [nucleotide binding]
1127134004390	putative dimer interface [polypeptide binding]; other site
1127134004391	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1127134004392	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134004393	UreD urease accessory protein; Region: UreD; cl00530
1127134004394	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1127134004395	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1127134004396	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134004397	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134004398	RNB domain; Region: RNB; pfam00773
1127134004399	This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955
1127134004400	CHAD domain; Region: CHAD; pfam05235
1127134004401	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1127134004402	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1127134004403	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134004404	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1127134004405	oligomerization interface [polypeptide binding]; other site
1127134004406	active site
1127134004407	metal binding site [ion binding]; metal-binding site
1127134004408	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1127134004409	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134004410	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1127134004411	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1127134004412	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1127134004413	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
1127134004414	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1127134004415	metal binding triad; other site
1127134004416	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1127134004417	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1127134004418	metal binding triad; other site
1127134004419	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1127134004420	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1127134004421	putative catalytic site [active]
1127134004422	putative metal binding site [ion binding]; other site
1127134004423	putative phosphate binding site [ion binding]; other site
1127134004424	Predicted metalloprotease [General function prediction only]; Region: COG2321
1127134004425	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1127134004426	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1127134004427	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134004428	M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674
1127134004429	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
1127134004430	metal binding site [ion binding]; metal-binding site
1127134004431	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
1127134004432	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
1127134004433	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
1127134004434	Protein of unknown function (DUF2568); Region: DUF2568; pfam10823
1127134004435	RDD family; Region: RDD; pfam06271
1127134004436	glutamine synthetase, type I; Region: GlnA; TIGR00653
1127134004437	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1127134004438	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1127134004439	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134004440	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004441	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1127134004443	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1127134004444	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134004445	S-adenosylmethionine binding site [chemical binding]; other site
1127134004446	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134004447	DNA-binding site [nucleotide binding]; DNA binding site
1127134004448	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134004449	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1127134004450	Walker A/P-loop; other site
1127134004451	ATP binding site [chemical binding]; other site
1127134004452	Q-loop/lid; other site
1127134004453	ABC transporter signature motif; other site
1127134004454	Walker B; other site
1127134004455	D-loop; other site
1127134004456	H-loop/switch region; other site
1127134004457	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1127134004458	MgtC family; Region: MgtC; pfam02308
1127134004459	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
1127134004460	elongation factor G; Reviewed; Region: PRK12740
1127134004461	G1 box; other site
1127134004462	putative GEF interaction site [polypeptide binding]; other site
1127134004463	GTP/Mg2+ binding site [chemical binding]; other site
1127134004464	Switch I region; other site
1127134004465	G2 box; other site
1127134004466	G3 box; other site
1127134004467	Switch II region; other site
1127134004468	G4 box; other site
1127134004469	G5 box; other site
1127134004470	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1127134004471	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1127134004472	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1127134004473	AAA ATPase domain; Region: AAA_16; pfam13191
1127134004474	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1127134004475	Family description; Region: UvrD_C_2; pfam13538
1127134004476	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1127134004477	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134004478	catalytic core [active]
1127134004479	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1127134004480	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1127134004481	putative active site [active]
1127134004482	putative metal binding site [ion binding]; other site
1127134004483	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1127134004484	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134004485	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134004486	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134004487	catalytic residues [active]
1127134004488	Caspase domain; Region: Peptidase_C14; pfam00656
1127134004489	AAA domain; Region: AAA_11; pfam13086
1127134004490	Part of AAA domain; Region: AAA_19; pfam13245
1127134004491	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1127134004492	AAA domain; Region: AAA_12; pfam13087
1127134004493	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134004494	S-adenosylmethionine binding site [chemical binding]; other site
1127134004495	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1127134004496	NIPSNAP; Region: NIPSNAP; pfam07978
1127134004497	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1127134004498	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1127134004499	structural tetrad; other site
1127134004500	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1127134004501	structural tetrad; other site
1127134004502	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
1127134004503	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1127134004504	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1127134004505	active site
1127134004506	catalytic site [active]
1127134004507	substrate binding site [chemical binding]; other site
1127134004508	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1127134004509	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134004510	ATP binding site [chemical binding]; other site
1127134004511	putative Mg++ binding site [ion binding]; other site
1127134004512	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134004513	nucleotide binding region [chemical binding]; other site
1127134004514	ATP-binding site [chemical binding]; other site
1127134004515	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
1127134004516	PglZ domain; Region: PglZ; pfam08665
1127134004517	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1127134004518	Nuclease-related domain; Region: NERD; pfam08378
1127134004519	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134004520	active site
1127134004521	ATP binding site [chemical binding]; other site
1127134004522	substrate binding site [chemical binding]; other site
1127134004523	activation loop (A-loop); other site
1127134004524	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134004525	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134004526	active site
1127134004527	ATP binding site [chemical binding]; other site
1127134004528	substrate binding site [chemical binding]; other site
1127134004529	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134004530	substrate binding site [chemical binding]; other site
1127134004531	activation loop (A-loop); other site
1127134004532	activation loop (A-loop); other site
1127134004533	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1127134004534	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1127134004535	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1127134004536	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134004537	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134004538	active site
1127134004539	ATP binding site [chemical binding]; other site
1127134004540	substrate binding site [chemical binding]; other site
1127134004541	activation loop (A-loop); other site
1127134004542	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1127134004543	active site
1127134004544	Part of AAA domain; Region: AAA_19; pfam13245
1127134004545	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1127134004546	AAA domain; Region: AAA_12; pfam13087
1127134004547	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134004548	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1127134004549	Predicted esterase [General function prediction only]; Region: COG0627
1127134004550	S-formylglutathione hydrolase; Region: PLN02442
1127134004551	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1127134004552	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1127134004553	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134004554	Walker A/P-loop; other site
1127134004555	ATP binding site [chemical binding]; other site
1127134004556	Q-loop/lid; other site
1127134004557	ABC transporter signature motif; other site
1127134004558	Walker B; other site
1127134004559	D-loop; other site
1127134004560	H-loop/switch region; other site
1127134004561	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1127134004562	NB-ARC domain; Region: NB-ARC; pfam00931
1127134004563	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134004564	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1127134004565	lipoyl synthase; Provisional; Region: PRK05481
1127134004566	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134004567	FeS/SAM binding site; other site
1127134004568	lipoate-protein ligase B; Provisional; Region: PRK14345
1127134004569	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1127134004570	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134004571	Coenzyme A binding pocket [chemical binding]; other site
1127134004572	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134004573	TIGR01777 family protein; Region: yfcH
1127134004574	NAD(P) binding site [chemical binding]; other site
1127134004575	active site
1127134004576	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1127134004577	E3 interaction surface; other site
1127134004578	lipoyl attachment site [posttranslational modification]; other site
1127134004579	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1127134004580	E3 interaction surface; other site
1127134004581	lipoyl attachment site [posttranslational modification]; other site
1127134004582	e3 binding domain; Region: E3_binding; pfam02817
1127134004583	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
1127134004584	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1127134004585	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1127134004586	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1127134004587	interface (dimer of trimers) [polypeptide binding]; other site
1127134004588	Substrate-binding/catalytic site; other site
1127134004589	Zn-binding sites [ion binding]; other site
1127134004590	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004591	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134004592	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1127134004593	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1127134004594	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1127134004595	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1127134004596	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1127134004597	homodimer interface [polypeptide binding]; other site
1127134004598	substrate-cofactor binding pocket; other site
1127134004599	catalytic residue [active]
1127134004600	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1127134004601	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1127134004602	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1127134004603	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1127134004604	putative dimer interface [polypeptide binding]; other site
1127134004605	active site pocket [active]
1127134004606	putative cataytic base [active]
1127134004607	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004608	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1127134004609	homotrimer interface [polypeptide binding]; other site
1127134004610	Walker A motif; other site
1127134004611	GTP binding site [chemical binding]; other site
1127134004612	Walker B motif; other site
1127134004613	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1127134004614	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1127134004615	conserved cys residue [active]
1127134004616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134004617	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134004618	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
1127134004619	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
1127134004620	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1127134004621	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1127134004622	substrate binding site [chemical binding]; other site
1127134004623	ATP binding site [chemical binding]; other site
1127134004624	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
1127134004625	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1127134004626	dimer interface [polypeptide binding]; other site
1127134004627	active site
1127134004628	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1127134004629	Ligand Binding Site [chemical binding]; other site
1127134004630	Molecular Tunnel; other site
1127134004631	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1127134004632	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1127134004633	Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270
1127134004634	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134004635	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134004636	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1127134004637	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1127134004638	putative active site [active]
1127134004639	putative metal binding site [ion binding]; other site
1127134004640	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1127134004641	SpoOM protein; Region: Spo0M; pfam07070
1127134004642	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134004643	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1127134004644	putative acyl-acceptor binding pocket; other site
1127134004645	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1127134004646	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1127134004647	nucleotide binding site [chemical binding]; other site
1127134004648	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1127134004649	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1127134004650	P loop; other site
1127134004651	Nucleotide binding site [chemical binding]; other site
1127134004652	DTAP/Switch II; other site
1127134004653	Switch I; other site
1127134004654	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
1127134004655	putative hydrophobic ligand binding site [chemical binding]; other site
1127134004656	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134004657	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1127134004658	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134004659	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
1127134004660	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134004661	NlpC/P60 family; Region: NLPC_P60; pfam00877
1127134004662	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134004663	NlpC/P60 family; Region: NLPC_P60; pfam00877
1127134004664	hypothetical protein; Validated; Region: PRK07883
1127134004665	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1127134004666	active site
1127134004667	catalytic site [active]
1127134004668	substrate binding site [chemical binding]; other site
1127134004669	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1127134004670	GIY-YIG motif/motif A; other site
1127134004671	active site
1127134004672	catalytic site [active]
1127134004673	putative DNA binding site [nucleotide binding]; other site
1127134004674	metal binding site [ion binding]; metal-binding site
1127134004675	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1127134004676	AsnC family; Region: AsnC_trans_reg; pfam01037
1127134004677	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1127134004678	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1127134004679	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1127134004680	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1127134004681	Subunit I/III interface [polypeptide binding]; other site
1127134004682	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1127134004683	Cytochrome c; Region: Cytochrom_C; pfam00034
1127134004684	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1127134004685	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1127134004686	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1127134004687	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1127134004688	iron-sulfur cluster [ion binding]; other site
1127134004689	[2Fe-2S] cluster binding site [ion binding]; other site
1127134004690	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1127134004691	heme bH binding site [chemical binding]; other site
1127134004692	Qi binding site; other site
1127134004693	intrachain domain interface; other site
1127134004694	heme bL binding site [chemical binding]; other site
1127134004695	interchain domain interface [polypeptide binding]; other site
1127134004696	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631
1127134004697	Qo binding site; other site
1127134004698	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1127134004699	Helix-turn-helix domain; Region: HTH_17; cl17695
1127134004700	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134004701	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134004702	active site
1127134004703	ATP binding site [chemical binding]; other site
1127134004704	substrate binding site [chemical binding]; other site
1127134004705	activation loop (A-loop); other site
1127134004706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1127134004707	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134004708	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134004709	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134004710	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1127134004711	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1127134004712	DNA-binding site [nucleotide binding]; DNA binding site
1127134004713	RNA-binding motif; other site
1127134004714	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1127134004715	active site lid residues [active]
1127134004716	substrate binding pocket [chemical binding]; other site
1127134004717	catalytic residues [active]
1127134004718	substrate-Mg2+ binding site; other site
1127134004719	aspartate-rich region 1; other site
1127134004720	aspartate-rich region 2; other site
1127134004721	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1127134004722	phytoene desaturase; Region: crtI_fam; TIGR02734
1127134004723	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134004724	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1127134004725	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1127134004726	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1127134004727	substrate binding pocket [chemical binding]; other site
1127134004728	chain length determination region; other site
1127134004729	substrate-Mg2+ binding site; other site
1127134004730	catalytic residues [active]
1127134004731	aspartate-rich region 1; other site
1127134004732	active site lid residues [active]
1127134004733	aspartate-rich region 2; other site
1127134004734	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1127134004735	FAD binding site [chemical binding]; other site
1127134004736	Protein of unknown function (DUF1684); Region: DUF1684; pfam07920
1127134004737	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1127134004738	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1127134004739	active site
1127134004740	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134004741	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1127134004742	Protein of unknown function (DUF422); Region: DUF422; cl00991
1127134004743	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1127134004744	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134004745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134004746	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1127134004747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134004748	Protein of unknown function (DUF3040); Region: DUF3040; pfam11239
1127134004749	MraZ protein; Region: MraZ; pfam02381
1127134004750	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1127134004751	MraW methylase family; Region: Methyltransf_5; cl17771
1127134004752	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1127134004753	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1127134004754	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1127134004755	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1127134004756	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1127134004757	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1127134004758	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1127134004759	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1127134004760	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1127134004761	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1127134004762	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1127134004763	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1127134004764	Mg++ binding site [ion binding]; other site
1127134004765	putative catalytic motif [active]
1127134004766	putative substrate binding site [chemical binding]; other site
1127134004767	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369
1127134004768	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1127134004769	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1127134004770	cell division protein FtsW; Region: ftsW; TIGR02614
1127134004771	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1127134004772	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1127134004773	active site
1127134004774	homodimer interface [polypeptide binding]; other site
1127134004775	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1127134004776	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1127134004777	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1127134004778	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1127134004779	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1127134004780	Cell division protein FtsQ; Region: FtsQ; pfam03799
1127134004781	cell division protein FtsZ; Validated; Region: PRK09330
1127134004782	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1127134004783	nucleotide binding site [chemical binding]; other site
1127134004784	SulA interaction site; other site
1127134004785	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1127134004786	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1127134004787	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1127134004788	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134004789	catalytic residue [active]
1127134004790	Protein of unknown function (DUF552); Region: DUF552; cl00775
1127134004791	Protein of unknown function (DUF552); Region: DUF552; cl00775
1127134004792	Predicted integral membrane protein [Function unknown]; Region: COG0762
1127134004793	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134004794	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1127134004795	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1127134004796	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1127134004797	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1127134004798	HIGH motif; other site
1127134004799	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1127134004800	active site
1127134004801	KMSKS motif; other site
1127134004802	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1127134004803	tRNA binding surface [nucleotide binding]; other site
1127134004804	anticodon binding site; other site
1127134004805	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134004806	NlpC/P60 family; Region: NLPC_P60; pfam00877
1127134004807	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1127134004808	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1127134004809	active site
1127134004810	tetramer interface; other site
1127134004811	DNA polymerase IV; Provisional; Region: PRK03348
1127134004812	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1127134004813	active site
1127134004814	DNA binding site [nucleotide binding]
1127134004815	Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602
1127134004816	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1127134004817	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1127134004818	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134004819	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1127134004820	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1127134004821	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1127134004822	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1127134004823	putative dimer interface [polypeptide binding]; other site
1127134004824	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134004825	lipoprotein signal peptidase; Provisional; Region: PRK14764
1127134004826	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1127134004827	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1127134004828	RNA binding surface [nucleotide binding]; other site
1127134004829	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1127134004830	active site
1127134004831	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134004832	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134004833	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1127134004834	dinuclear metal binding motif [ion binding]; other site
1127134004835	classical (c) SDRs; Region: SDR_c; cd05233
1127134004836	short chain dehydrogenase; Provisional; Region: PRK05650
1127134004837	NAD(P) binding site [chemical binding]; other site
1127134004838	active site
1127134004839	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134004840	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1127134004841	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134004842	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134004843	acetyl-CoA synthetase; Provisional; Region: PRK00174
1127134004844	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1127134004845	active site
1127134004846	CoA binding site [chemical binding]; other site
1127134004847	acyl-activating enzyme (AAE) consensus motif; other site
1127134004848	AMP binding site [chemical binding]; other site
1127134004849	acetate binding site [chemical binding]; other site
1127134004850	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1127134004851	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1127134004852	Na binding site [ion binding]; other site
1127134004853	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1127134004854	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1127134004855	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1127134004856	Na binding site [ion binding]; other site
1127134004857	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1127134004858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134004859	active site
1127134004860	phosphorylation site [posttranslational modification]
1127134004861	intermolecular recognition site; other site
1127134004862	dimerization interface [polypeptide binding]; other site
1127134004863	LytTr DNA-binding domain; Region: LytTR; smart00850
1127134004864	Histidine kinase; Region: His_kinase; pfam06580
1127134004865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134004866	ATP binding site [chemical binding]; other site
1127134004867	Mg2+ binding site [ion binding]; other site
1127134004868	G-X-G motif; other site
1127134004869	Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453
1127134004870	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1127134004871	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1127134004872	active site
1127134004873	PHP Thumb interface [polypeptide binding]; other site
1127134004874	metal binding site [ion binding]; metal-binding site
1127134004875	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1127134004876	generic binding surface II; other site
1127134004877	generic binding surface I; other site
1127134004878	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134004879	Cytochrome P450; Region: p450; cl12078
1127134004880	phytoene desaturase; Region: crtI_fam; TIGR02734
1127134004881	AAA ATPase domain; Region: AAA_16; pfam13191
1127134004882	Predicted ATPase [General function prediction only]; Region: COG3903
1127134004883	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1127134004884	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134004885	putative substrate translocation pore; other site
1127134004886	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004887	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004888	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1127134004889	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134004890	S-adenosylmethionine binding site [chemical binding]; other site
1127134004891	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
1127134004892	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
1127134004893	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
1127134004894	catalytic site [active]
1127134004895	active site
1127134004896	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1127134004897	threonine dehydratase; Validated; Region: PRK08639
1127134004898	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1127134004899	tetramer interface [polypeptide binding]; other site
1127134004900	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134004901	catalytic residue [active]
1127134004902	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1127134004903	putative Ile/Val binding site [chemical binding]; other site
1127134004904	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1127134004905	AAA ATPase domain; Region: AAA_16; pfam13191
1127134004906	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134004907	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134004908	DNA binding residues [nucleotide binding]
1127134004909	dimerization interface [polypeptide binding]; other site
1127134004910	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134004911	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134004912	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1127134004913	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134004914	Walker A/P-loop; other site
1127134004915	ATP binding site [chemical binding]; other site
1127134004916	Q-loop/lid; other site
1127134004917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134004918	ABC transporter signature motif; other site
1127134004919	Walker B; other site
1127134004920	D-loop; other site
1127134004921	H-loop/switch region; other site
1127134004922	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134004923	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134004924	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1127134004925	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1127134004926	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1127134004927	active site
1127134004928	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1127134004929	Cupin domain; Region: Cupin_2; pfam07883
1127134004930	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1127134004931	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
1127134004932	malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401
1127134004933	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
1127134004934	active site
1127134004935	catalytic site [active]
1127134004936	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
1127134004937	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1127134004938	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1127134004939	active site
1127134004940	catalytic site [active]
1127134004941	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
1127134004942	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134004943	inhibitor-cofactor binding pocket; inhibition site
1127134004944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134004945	catalytic residue [active]
1127134004946	Cupin domain; Region: Cupin_2; pfam07883
1127134004947	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134004948	putative DNA binding site [nucleotide binding]; other site
1127134004949	putative Zn2+ binding site [ion binding]; other site
1127134004950	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1127134004951	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134004952	catalytic residue [active]
1127134004953	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1127134004954	AAA domain; Region: AAA_26; pfam13500
1127134004955	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1127134004956	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1127134004957	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134004958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134004959	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1127134004960	putative substrate translocation pore; other site
1127134004961	MarR family; Region: MarR_2; pfam12802
1127134004962	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1127134004963	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1127134004964	putative ligand binding residues [chemical binding]; other site
1127134004965	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1127134004966	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1127134004967	Walker A/P-loop; other site
1127134004968	ATP binding site [chemical binding]; other site
1127134004969	Q-loop/lid; other site
1127134004970	ABC transporter signature motif; other site
1127134004971	Walker B; other site
1127134004972	D-loop; other site
1127134004973	H-loop/switch region; other site
1127134004974	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1127134004975	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1127134004976	dimer interface [polypeptide binding]; other site
1127134004977	putative PBP binding regions; other site
1127134004978	ABC-ATPase subunit  interface; other site
1127134004979	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1127134004980	nucleophilic elbow; other site
1127134004981	catalytic triad; other site
1127134004982	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1127134004983	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1127134004984	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1127134004985	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134004986	dimer interface [polypeptide binding]; other site
1127134004987	conserved gate region; other site
1127134004988	putative PBP binding loops; other site
1127134004989	ABC-ATPase subunit interface; other site
1127134004990	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1127134004991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134004992	Walker A/P-loop; other site
1127134004993	ATP binding site [chemical binding]; other site
1127134004994	Q-loop/lid; other site
1127134004995	ABC transporter signature motif; other site
1127134004996	Walker B; other site
1127134004997	D-loop; other site
1127134004998	H-loop/switch region; other site
1127134004999	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1127134005000	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005001	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134005002	biotin synthase; Validated; Region: PRK06256
1127134005003	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134005004	FeS/SAM binding site; other site
1127134005005	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1127134005006	Protein of unknown function (DUF2567); Region: DUF2567; pfam10821
1127134005007	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
1127134005008	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1127134005009	nudix motif; other site
1127134005010	quinolinate synthetase; Provisional; Region: PRK09375
1127134005011	L-aspartate oxidase; Provisional; Region: PRK07804
1127134005012	L-aspartate oxidase; Provisional; Region: PRK06175
1127134005013	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1127134005014	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896
1127134005015	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1127134005016	dimerization interface [polypeptide binding]; other site
1127134005017	active site
1127134005018	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1127134005019	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134005020	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1127134005021	acyl-activating enzyme (AAE) consensus motif; other site
1127134005022	acyl-activating enzyme (AAE) consensus motif; other site
1127134005023	putative AMP binding site [chemical binding]; other site
1127134005024	putative active site [active]
1127134005025	putative CoA binding site [chemical binding]; other site
1127134005026	lipid-transfer protein; Provisional; Region: PRK08256
1127134005027	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134005028	active site
1127134005029	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134005030	active site
1127134005031	catalytic site [active]
1127134005032	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134005033	active site 2 [active]
1127134005034	active site 1 [active]
1127134005035	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1127134005036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134005037	NAD(P) binding site [chemical binding]; other site
1127134005038	active site
1127134005039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134005040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005041	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134005042	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005043	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1127134005044	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134005045	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1127134005046	active site
1127134005047	ATP binding site [chemical binding]; other site
1127134005048	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1127134005049	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134005050	YaeQ protein; Region: YaeQ; cl01913
1127134005051	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134005052	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134005053	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1127134005054	dimerization interface [polypeptide binding]; other site
1127134005055	substrate binding pocket [chemical binding]; other site
1127134005056	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
1127134005057	active site
1127134005058	catalytic triad [active]
1127134005059	oxyanion hole [active]
1127134005060	Lipase (class 2); Region: Lipase_2; pfam01674
1127134005061	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134005062	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134005063	non-specific DNA binding site [nucleotide binding]; other site
1127134005064	salt bridge; other site
1127134005065	sequence-specific DNA binding site [nucleotide binding]; other site
1127134005066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134005067	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134005068	NAD(P) binding site [chemical binding]; other site
1127134005069	active site
1127134005070	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005071	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134005072	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134005073	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134005074	active site
1127134005075	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
1127134005076	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1127134005077	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1127134005078	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134005079	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134005080	active site
1127134005081	ATP binding site [chemical binding]; other site
1127134005082	substrate binding site [chemical binding]; other site
1127134005083	activation loop (A-loop); other site
1127134005084	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134005085	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134005086	active site
1127134005087	catalytic tetrad [active]
1127134005088	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1127134005089	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
1127134005090	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1127134005091	NAD binding site [chemical binding]; other site
1127134005092	dimerization interface [polypeptide binding]; other site
1127134005093	product binding site; other site
1127134005094	substrate binding site [chemical binding]; other site
1127134005095	zinc binding site [ion binding]; other site
1127134005096	catalytic residues [active]
1127134005097	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
1127134005098	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134005099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134005100	homodimer interface [polypeptide binding]; other site
1127134005101	catalytic residue [active]
1127134005102	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1127134005103	putative active site pocket [active]
1127134005104	4-fold oligomerization interface [polypeptide binding]; other site
1127134005105	metal binding residues [ion binding]; metal-binding site
1127134005106	3-fold/trimer interface [polypeptide binding]; other site
1127134005107	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1127134005108	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1127134005109	putative active site [active]
1127134005110	oxyanion strand; other site
1127134005111	catalytic triad [active]
1127134005112	Histidine kinase; Region: HisKA_3; pfam07730
1127134005113	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134005114	ATP binding site [chemical binding]; other site
1127134005115	Mg2+ binding site [ion binding]; other site
1127134005116	G-X-G motif; other site
1127134005117	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134005118	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134005119	active site
1127134005120	phosphorylation site [posttranslational modification]
1127134005121	intermolecular recognition site; other site
1127134005122	dimerization interface [polypeptide binding]; other site
1127134005123	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134005124	DNA binding residues [nucleotide binding]
1127134005125	dimerization interface [polypeptide binding]; other site
1127134005126	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1127134005127	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1127134005128	catalytic residues [active]
1127134005129	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1127134005130	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1127134005131	active site
1127134005132	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1127134005133	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1127134005134	substrate binding site [chemical binding]; other site
1127134005135	glutamase interaction surface [polypeptide binding]; other site
1127134005136	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1127134005137	acyl-CoA synthetase; Validated; Region: PRK09192
1127134005138	acyl-activating enzyme (AAE) consensus motif; other site
1127134005139	active site
1127134005140	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134005141	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1127134005142	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1127134005143	active site
1127134005144	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1127134005145	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1127134005146	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1127134005147	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134005148	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134005149	catalytic residue [active]
1127134005150	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1127134005151	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134005152	MarR family; Region: MarR_2; cl17246
1127134005153	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1127134005154	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1127134005155	catalytic triad [active]
1127134005156	anthranilate synthase component I; Provisional; Region: PRK13571
1127134005157	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1127134005158	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1127134005159	Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534
1127134005160	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1127134005161	active site
1127134005162	ribulose/triose binding site [chemical binding]; other site
1127134005163	phosphate binding site [ion binding]; other site
1127134005164	substrate (anthranilate) binding pocket [chemical binding]; other site
1127134005165	product (indole) binding pocket [chemical binding]; other site
1127134005166	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1127134005167	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1127134005168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134005169	catalytic residue [active]
1127134005170	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1127134005171	substrate binding site [chemical binding]; other site
1127134005172	active site
1127134005173	catalytic residues [active]
1127134005174	heterodimer interface [polypeptide binding]; other site
1127134005175	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108
1127134005176	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
1127134005177	Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432
1127134005178	pyruvate kinase; Provisional; Region: PRK06247
1127134005179	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1127134005180	active site
1127134005181	domain interfaces; other site
1127134005182	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1127134005183	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1127134005184	active site
1127134005185	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1127134005186	catalytic triad [active]
1127134005187	dimer interface [polypeptide binding]; other site
1127134005188	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1127134005189	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1127134005190	active site
1127134005191	Domain of unknown function (DUF4188); Region: DUF4188; pfam13826
1127134005192	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134005193	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005194	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134005195	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134005196	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1127134005197	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1127134005198	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134005199	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134005200	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134005201	DNA binding residues [nucleotide binding]
1127134005202	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1127134005203	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134005204	putative NAD(P) binding site [chemical binding]; other site
1127134005205	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134005206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005207	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134005208	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1127134005209	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134005210	dimer interface [polypeptide binding]; other site
1127134005211	active site
1127134005212	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1127134005213	classical (c) SDRs; Region: SDR_c; cd05233
1127134005214	NAD(P) binding site [chemical binding]; other site
1127134005215	active site
1127134005216	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1127134005217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134005218	NAD(P) binding site [chemical binding]; other site
1127134005219	active site
1127134005220	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1127134005221	putative active site [active]
1127134005222	putative catalytic site [active]
1127134005223	Secretory lipase; Region: LIP; pfam03583
1127134005224	CHAT domain; Region: CHAT; cl17868
1127134005225	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1127134005226	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1127134005227	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
1127134005228	nudix motif; other site
1127134005229	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
1127134005231	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134005232	sequence-specific DNA binding site [nucleotide binding]; other site
1127134005233	salt bridge; other site
1127134005234	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134005235	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1127134005236	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1127134005237	Int/Topo IB signature motif; other site
1127134005238	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1127134005239	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1127134005240	Walker A/P-loop; other site
1127134005241	ATP binding site [chemical binding]; other site
1127134005242	Q-loop/lid; other site
1127134005243	ABC transporter signature motif; other site
1127134005244	Walker B; other site
1127134005245	D-loop; other site
1127134005246	H-loop/switch region; other site
1127134005247	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1127134005248	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1127134005249	Histidine kinase; Region: HisKA_3; pfam07730
1127134005250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134005251	ATP binding site [chemical binding]; other site
1127134005252	Mg2+ binding site [ion binding]; other site
1127134005253	G-X-G motif; other site
1127134005254	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134005255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134005256	active site
1127134005257	phosphorylation site [posttranslational modification]
1127134005258	intermolecular recognition site; other site
1127134005259	dimerization interface [polypeptide binding]; other site
1127134005260	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134005261	DNA binding residues [nucleotide binding]
1127134005262	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134005263	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1127134005264	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1127134005265	pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853
1127134005266	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1127134005267	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134005268	putative Zn2+ binding site [ion binding]; other site
1127134005269	putative DNA binding site [nucleotide binding]; other site
1127134005270	dimerization interface [polypeptide binding]; other site
1127134005271	MarR family; Region: MarR_2; pfam12802
1127134005272	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134005273	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134005274	Walker A/P-loop; other site
1127134005275	ATP binding site [chemical binding]; other site
1127134005276	Q-loop/lid; other site
1127134005277	ABC transporter signature motif; other site
1127134005278	Walker B; other site
1127134005279	D-loop; other site
1127134005280	H-loop/switch region; other site
1127134005281	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1127134005282	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134005283	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134005284	putative metal binding site [ion binding]; other site
1127134005285	Ion channel; Region: Ion_trans_2; pfam07885
1127134005286	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1127134005287	TrkA-N domain; Region: TrkA_N; pfam02254
1127134005288	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
1127134005289	Na2 binding site [ion binding]; other site
1127134005290	putative substrate binding site 1 [chemical binding]; other site
1127134005291	Na binding site 1 [ion binding]; other site
1127134005292	putative substrate binding site 2 [chemical binding]; other site
1127134005293	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
1127134005294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134005295	active site
1127134005296	phosphorylation site [posttranslational modification]
1127134005297	intermolecular recognition site; other site
1127134005298	dimerization interface [polypeptide binding]; other site
1127134005299	ANTAR domain; Region: ANTAR; pfam03861
1127134005300	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1127134005301	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1127134005302	dimerization interface [polypeptide binding]; other site
1127134005303	ligand binding site [chemical binding]; other site
1127134005304	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1127134005305	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1127134005306	TM-ABC transporter signature motif; other site
1127134005307	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1127134005308	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1127134005309	TM-ABC transporter signature motif; other site
1127134005310	Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14702302; Product type t : transporter
1127134005311	Evidence 2b : Function of strongly homologous gene; PubMedId : 14702302; Product type t : transporter
1127134005312	DNA polymerase I; Provisional; Region: PRK05755
1127134005313	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1127134005314	active site
1127134005315	metal binding site 1 [ion binding]; metal-binding site
1127134005316	putative 5' ssDNA interaction site; other site
1127134005317	metal binding site 3; metal-binding site
1127134005318	metal binding site 2 [ion binding]; metal-binding site
1127134005319	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1127134005320	putative DNA binding site [nucleotide binding]; other site
1127134005321	putative metal binding site [ion binding]; other site
1127134005322	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1127134005323	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1127134005324	active site
1127134005325	DNA binding site [nucleotide binding]
1127134005326	catalytic site [active]
1127134005327	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1127134005328	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1127134005329	catalytic residues [active]
1127134005330	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
1127134005331	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1127134005332	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134005333	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1127134005334	substrate binding pocket [chemical binding]; other site
1127134005335	membrane-bound complex binding site; other site
1127134005336	hinge residues; other site
1127134005337	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1127134005338	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134005339	dimer interface [polypeptide binding]; other site
1127134005340	conserved gate region; other site
1127134005341	putative PBP binding loops; other site
1127134005342	ABC-ATPase subunit interface; other site
1127134005343	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1127134005344	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1127134005345	Walker A/P-loop; other site
1127134005346	ATP binding site [chemical binding]; other site
1127134005347	Q-loop/lid; other site
1127134005348	ABC transporter signature motif; other site
1127134005349	Walker B; other site
1127134005350	D-loop; other site
1127134005351	H-loop/switch region; other site
1127134005352	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134005353	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134005354	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1127134005355	dimerization interface [polypeptide binding]; other site
1127134005356	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134005357	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134005358	Berberine and berberine like; Region: BBE; pfam08031
1127134005359	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1127134005360	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1127134005361	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134005362	S-adenosylmethionine binding site [chemical binding]; other site
1127134005363	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899
1127134005364	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1127134005365	RNA binding site [nucleotide binding]; other site
1127134005366	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1127134005367	RNA binding site [nucleotide binding]; other site
1127134005368	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1127134005369	RNA binding site [nucleotide binding]; other site
1127134005370	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1127134005371	RNA binding site [nucleotide binding]; other site
1127134005372	dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333
1127134005373	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1127134005374	ATP-binding [chemical binding]; other site
1127134005375	CoA-binding site [chemical binding]; other site
1127134005376	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1127134005377	Protein of unknown function (DUF402); Region: DUF402; cl00979
1127134005378	excinuclease ABC subunit B; Provisional; Region: PRK05298
1127134005379	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134005380	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134005381	nucleotide binding region [chemical binding]; other site
1127134005382	ATP-binding site [chemical binding]; other site
1127134005383	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1127134005384	UvrB/uvrC motif; Region: UVR; pfam02151
1127134005385	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134005386	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134005387	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1127134005388	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1127134005389	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1127134005390	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
1127134005391	putative dimer interface [polypeptide binding]; other site
1127134005392	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134005393	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1127134005394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134005395	Predicted membrane protein [Function unknown]; Region: COG2259
1127134005396	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134005397	Ligand Binding Site [chemical binding]; other site
1127134005398	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1127134005399	Part of AAA domain; Region: AAA_19; pfam13245
1127134005400	Family description; Region: UvrD_C_2; pfam13538
1127134005401	PAS fold; Region: PAS; pfam00989
1127134005402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1127134005403	putative active site [active]
1127134005404	heme pocket [chemical binding]; other site
1127134005405	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1127134005406	PAS domain; Region: PAS_9; pfam13426
1127134005407	putative active site [active]
1127134005408	heme pocket [chemical binding]; other site
1127134005409	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1127134005410	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1127134005411	metal binding site [ion binding]; metal-binding site
1127134005412	active site
1127134005413	I-site; other site
1127134005414	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1127134005415	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134005416	active site
1127134005417	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1127134005418	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1127134005419	GAF domain; Region: GAF_3; pfam13492
1127134005420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134005421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134005422	Mg2+ binding site [ion binding]; other site
1127134005423	G-X-G motif; other site
1127134005424	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134005425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134005426	active site
1127134005427	phosphorylation site [posttranslational modification]
1127134005428	intermolecular recognition site; other site
1127134005429	dimerization interface [polypeptide binding]; other site
1127134005430	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134005431	DNA binding residues [nucleotide binding]
1127134005432	dimerization interface [polypeptide binding]; other site
1127134005433	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1127134005434	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1127134005435	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1127134005436	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1127134005437	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134005438	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1127134005439	DinB superfamily; Region: DinB_2; pfam12867
1127134005440	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1127134005441	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1127134005442	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1127134005443	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1127134005444	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1127134005445	23S rRNA binding site [nucleotide binding]; other site
1127134005446	L21 binding site [polypeptide binding]; other site
1127134005447	L13 binding site [polypeptide binding]; other site
1127134005448	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1127134005449	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1127134005450	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1127134005451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134005452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134005454	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134005455	putative substrate translocation pore; other site
1127134005456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134005457	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1127134005458	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1127134005459	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1127134005460	dimer interface [polypeptide binding]; other site
1127134005461	motif 1; other site
1127134005462	active site
1127134005463	motif 2; other site
1127134005464	motif 3; other site
1127134005465	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1127134005466	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1127134005467	putative tRNA-binding site [nucleotide binding]; other site
1127134005468	B3/4 domain; Region: B3_4; pfam03483
1127134005469	tRNA synthetase B5 domain; Region: B5; smart00874
1127134005470	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1127134005471	dimer interface [polypeptide binding]; other site
1127134005472	motif 1; other site
1127134005473	motif 3; other site
1127134005474	motif 2; other site
1127134005475	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1127134005476	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134005477	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1127134005478	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134005479	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1127134005480	Protein of unknown function (DUF461); Region: DUF461; cl01071
1127134005481	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
1127134005482	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1127134005483	conserved cys residue [active]
1127134005484	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134005485	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134005486	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134005487	active site
1127134005488	ATP binding site [chemical binding]; other site
1127134005489	substrate binding site [chemical binding]; other site
1127134005490	activation loop (A-loop); other site
1127134005491	RDD family; Region: RDD; pfam06271
1127134005492	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1127134005493	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1127134005494	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1127134005495	maltose O-acetyltransferase; Provisional; Region: PRK10092
1127134005496	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1127134005497	active site
1127134005498	substrate binding site [chemical binding]; other site
1127134005499	trimer interface [polypeptide binding]; other site
1127134005500	CoA binding site [chemical binding]; other site
1127134005501	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1127134005502	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
1127134005503	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005504	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1127134005505	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134005506	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134005507	HTH domain; Region: HTH_11; pfam08279
1127134005508	WYL domain; Region: WYL; pfam13280
1127134005509	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1127134005510	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134005511	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134005512	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134005513	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134005514	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134005515	YCII-related domain; Region: YCII; cl00999
1127134005516	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134005517	RibD C-terminal domain; Region: RibD_C; cl17279
1127134005518	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1127134005519	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1127134005520	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1127134005521	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1127134005522	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1127134005523	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1127134005524	heterotetramer interface [polypeptide binding]; other site
1127134005525	active site pocket [active]
1127134005526	cleavage site
1127134005527	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1127134005528	feedback inhibition sensing region; other site
1127134005529	homohexameric interface [polypeptide binding]; other site
1127134005530	nucleotide binding site [chemical binding]; other site
1127134005531	N-acetyl-L-glutamate binding site [chemical binding]; other site
1127134005532	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
1127134005533	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134005534	inhibitor-cofactor binding pocket; inhibition site
1127134005535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134005536	catalytic residue [active]
1127134005537	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1127134005538	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1127134005539	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1127134005540	Arginine repressor [Transcription]; Region: ArgR; COG1438
1127134005541	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1127134005542	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1127134005543	GYD domain; Region: GYD; pfam08734
1127134005544	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1127134005545	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1127134005546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134005547	Histidine kinase; Region: HisKA_3; pfam07730
1127134005548	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134005549	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134005550	active site
1127134005551	phosphorylation site [posttranslational modification]
1127134005552	intermolecular recognition site; other site
1127134005553	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134005554	DNA binding residues [nucleotide binding]
1127134005555	dimerization interface [polypeptide binding]; other site
1127134005556	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134005557	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134005558	argininosuccinate synthase; Provisional; Region: PRK13820
1127134005559	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1127134005560	ANP binding site [chemical binding]; other site
1127134005561	Substrate Binding Site II [chemical binding]; other site
1127134005562	Substrate Binding Site I [chemical binding]; other site
1127134005563	argininosuccinate lyase; Provisional; Region: PRK00855
1127134005564	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1127134005565	active sites [active]
1127134005566	tetramer interface [polypeptide binding]; other site
1127134005567	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1127134005568	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1127134005569	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1127134005570	active site
1127134005571	metal binding site [ion binding]; metal-binding site
1127134005572	nudix motif; other site
1127134005573	acyl-CoA synthetase; Validated; Region: PRK07868
1127134005574	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1127134005575	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134005576	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134005577	active site
1127134005578	CoA binding site [chemical binding]; other site
1127134005579	AMP binding site [chemical binding]; other site
1127134005580	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1127134005581	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1127134005582	inhibitor-cofactor binding pocket; inhibition site
1127134005583	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134005584	catalytic residue [active]
1127134005585	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134005586	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1127134005587	active site
1127134005588	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
1127134005589	GtrA-like protein; Region: GtrA; pfam04138
1127134005590	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1127134005591	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005592	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134005593	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134005594	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1127134005595	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134005596	Walker A/P-loop; other site
1127134005597	ATP binding site [chemical binding]; other site
1127134005598	Q-loop/lid; other site
1127134005599	ABC transporter signature motif; other site
1127134005600	Walker B; other site
1127134005601	D-loop; other site
1127134005602	H-loop/switch region; other site
1127134005603	multicopper oxidase; Provisional; Region: PRK10965
1127134005604	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1127134005605	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1127134005606	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1127134005607	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134005608	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134005609	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134005610	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134005611	DNA binding residues [nucleotide binding]
1127134005612	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134005613	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1127134005614	active site
1127134005615	DNA binding site [nucleotide binding]
1127134005616	DoxX-like family; Region: DoxX_2; pfam13564
1127134005617	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1127134005618	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1127134005619	active site
1127134005620	HIGH motif; other site
1127134005621	dimer interface [polypeptide binding]; other site
1127134005622	KMSKS motif; other site
1127134005623	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1127134005624	RNA binding surface [nucleotide binding]; other site
1127134005625	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1127134005626	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134005627	active site
1127134005628	motif I; other site
1127134005629	motif II; other site
1127134005630	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1127134005631	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1127134005632	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1127134005633	RNA binding surface [nucleotide binding]; other site
1127134005634	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1127134005635	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
1127134005636	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1127134005637	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1127134005638	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134005639	Walker A/P-loop; other site
1127134005640	ATP binding site [chemical binding]; other site
1127134005641	Q-loop/lid; other site
1127134005642	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1127134005643	ABC transporter signature motif; other site
1127134005644	Walker B; other site
1127134005645	D-loop; other site
1127134005646	H-loop/switch region; other site
1127134005647	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
1127134005648	putative hydrophobic ligand binding site [chemical binding]; other site
1127134005649	protein interface [polypeptide binding]; other site
1127134005650	gate; other site
1127134005651	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1127134005652	ATP-binding site [chemical binding]; other site
1127134005653	Gluconate-6-phosphate binding site [chemical binding]; other site
1127134005654	Shikimate kinase; Region: SKI; pfam01202
1127134005655	GntP family permease; Region: GntP_permease; pfam02447
1127134005656	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1127134005657	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
1127134005658	Thiamine pyrophosphokinase; Region: TPK; cl08415
1127134005659	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
1127134005660	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1127134005661	CTP synthetase; Validated; Region: pyrG; PRK05380
1127134005662	active site
1127134005663	UTP binding site [chemical binding]; other site
1127134005664	Catalytic site [active]
1127134005665	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1127134005666	active site
1127134005667	putative oxyanion hole; other site
1127134005668	catalytic triad [active]
1127134005669	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1127134005670	dimer interface [polypeptide binding]; other site
1127134005671	active site
1127134005672	ADP-ribose binding site [chemical binding]; other site
1127134005673	nudix motif; other site
1127134005674	metal binding site [ion binding]; metal-binding site
1127134005675	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1127134005676	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1127134005677	active site
1127134005678	Int/Topo IB signature motif; other site
1127134005679	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1127134005680	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1127134005681	P-loop; other site
1127134005682	Magnesium ion binding site [ion binding]; other site
1127134005683	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1127134005684	Magnesium ion binding site [ion binding]; other site
1127134005685	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1127134005686	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1127134005687	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1127134005688	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1127134005689	RNA binding surface [nucleotide binding]; other site
1127134005690	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1127134005691	active site
1127134005692	cytidylate kinase; Provisional; Region: cmk; PRK00023
1127134005693	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1127134005694	active site
1127134005695	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1127134005696	CMP-binding site; other site
1127134005697	The sites determining sugar specificity; other site
1127134005698	GTP-binding protein Der; Reviewed; Region: PRK03003
1127134005699	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1127134005700	G1 box; other site
1127134005701	GTP/Mg2+ binding site [chemical binding]; other site
1127134005702	Switch I region; other site
1127134005703	G2 box; other site
1127134005704	Switch II region; other site
1127134005705	G3 box; other site
1127134005706	G4 box; other site
1127134005707	G5 box; other site
1127134005708	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1127134005709	G1 box; other site
1127134005710	GTP/Mg2+ binding site [chemical binding]; other site
1127134005711	Switch I region; other site
1127134005712	G2 box; other site
1127134005713	G3 box; other site
1127134005714	Switch II region; other site
1127134005715	G4 box; other site
1127134005716	G5 box; other site
1127134005717	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1127134005718	dimerization domain swap beta strand [polypeptide binding]; other site
1127134005719	regulatory protein interface [polypeptide binding]; other site
1127134005720	active site
1127134005721	regulatory phosphorylation site [posttranslational modification]; other site
1127134005722	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1127134005723	active site
1127134005724	phosphorylation site [posttranslational modification]
1127134005725	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1127134005726	active site
1127134005727	P-loop; other site
1127134005728	phosphorylation site [posttranslational modification]
1127134005729	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
1127134005730	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1127134005731	putative substrate binding site [chemical binding]; other site
1127134005732	putative ATP binding site [chemical binding]; other site
1127134005733	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1127134005734	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1127134005735	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1127134005736	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1127134005737	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1127134005738	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1127134005739	carboxylate-amine ligase; Provisional; Region: PRK13517
1127134005740	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1127134005741	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1127134005742	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134005743	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134005744	catalytic residue [active]
1127134005745	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1127134005746	hydroperoxidase II; Provisional; Region: katE; PRK11249
1127134005747	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1127134005748	heme binding pocket [chemical binding]; other site
1127134005749	Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132
1127134005750	domain interactions; other site
1127134005751	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1127134005752	anti sigma factor interaction site; other site
1127134005753	regulatory phosphorylation site [posttranslational modification]; other site
1127134005754	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1127134005755	PAS fold; Region: PAS_3; pfam08447
1127134005756	putative active site [active]
1127134005757	heme pocket [chemical binding]; other site
1127134005758	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012
1127134005759	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1127134005760	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1127134005761	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134005762	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1127134005763	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134005764	DNA binding residues [nucleotide binding]
1127134005765	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1127134005766	Fe-S cluster binding site [ion binding]; other site
1127134005767	active site
1127134005768	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1127134005769	F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557
1127134005770	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1127134005771	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1127134005772	active site
1127134005773	metal binding site [ion binding]; metal-binding site
1127134005774	BON domain; Region: BON; pfam04972
1127134005775	Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690
1127134005776	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1127134005777	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134005778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134005779	motif II; other site
1127134005780	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134005781	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134005782	putative substrate translocation pore; other site
1127134005783	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1127134005784	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1127134005785	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1127134005786	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1127134005787	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134005788	dimerization interface [polypeptide binding]; other site
1127134005789	putative DNA binding site [nucleotide binding]; other site
1127134005790	hypothetical protein; Provisional; Region: PRK08317
1127134005791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134005792	S-adenosylmethionine binding site [chemical binding]; other site
1127134005793	YCII-related domain; Region: YCII; cl00999
1127134005794	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134005795	PQQ-like domain; Region: PQQ_2; pfam13360
1127134005796	PQQ-like domain; Region: PQQ_2; pfam13360
1127134005797	Predicted esterase [General function prediction only]; Region: COG0627
1127134005798	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
1127134005799	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134005800	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134005801	aminotransferase AlaT; Validated; Region: PRK09265
1127134005802	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134005803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134005804	homodimer interface [polypeptide binding]; other site
1127134005805	catalytic residue [active]
1127134005806	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134005807	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1127134005808	NAD(P) binding site [chemical binding]; other site
1127134005809	active site
1127134005810	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1127134005811	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134005812	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134005813	Walker A motif; other site
1127134005814	ATP binding site [chemical binding]; other site
1127134005815	Walker B motif; other site
1127134005816	arginine finger; other site
1127134005817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134005818	Walker A motif; other site
1127134005819	ATP binding site [chemical binding]; other site
1127134005820	Walker B motif; other site
1127134005821	arginine finger; other site
1127134005822	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1127134005823	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1127134005824	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1127134005825	PhoD-like phosphatase; Region: PhoD; pfam09423
1127134005826	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1127134005827	putative active site [active]
1127134005828	putative metal binding site [ion binding]; other site
1127134005829	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1127134005830	SnoaL-like domain; Region: SnoaL_4; pfam13577
1127134005831	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1127134005832	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134005833	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134005834	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134005835	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1127134005836	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134005837	Cytochrome P450; Region: p450; cl12078
1127134005838	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134005839	FMN binding site [chemical binding]; other site
1127134005840	substrate binding site [chemical binding]; other site
1127134005841	putative catalytic residue [active]
1127134005842	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
1127134005843	nudix motif; other site
1127134005844	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1127134005845	Short C-terminal domain; Region: SHOCT; pfam09851
1127134005846	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1127134005847	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1127134005848	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1127134005849	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1127134005850	[2Fe-2S] cluster binding site [ion binding]; other site
1127134005851	Predicted esterase [General function prediction only]; Region: COG0627
1127134005852	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1127134005853	Pirin-related protein [General function prediction only]; Region: COG1741
1127134005854	Pirin; Region: Pirin; pfam02678
1127134005855	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1127134005856	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1127134005857	Class I aldolases; Region: Aldolase_Class_I; cl17187
1127134005858	catalytic residue [active]
1127134005859	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134005860	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134005861	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1127134005862	putative dimerization interface [polypeptide binding]; other site
1127134005863	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134005864	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134005865	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134005866	DNA binding residues [nucleotide binding]
1127134005867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
1127134005868	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1127134005869	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1127134005870	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134005871	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1127134005872	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134005873	acyl-activating enzyme (AAE) consensus motif; other site
1127134005874	AMP binding site [chemical binding]; other site
1127134005875	active site
1127134005876	CoA binding site [chemical binding]; other site
1127134005877	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1127134005878	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1127134005879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134005880	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
1127134005881	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1127134005882	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134005883	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134005884	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1127134005885	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134005886	carboxyltransferase (CT) interaction site; other site
1127134005887	biotinylation site [posttranslational modification]; other site
1127134005888	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134005889	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134005890	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134005891	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134005892	active site
1127134005893	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134005894	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1127134005895	DNA binding residues [nucleotide binding]
1127134005896	dimer interface [polypeptide binding]; other site
1127134005897	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1127134005898	Protein of unknown function (DUF1345); Region: DUF1345; pfam07077
1127134005899	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134005900	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134005901	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1127134005902	dimerization interface [polypeptide binding]; other site
1127134005903	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1127134005904	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1127134005905	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
1127134005906	putative molybdopterin cofactor binding site [chemical binding]; other site
1127134005907	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
1127134005908	putative molybdopterin cofactor binding site; other site
1127134005909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134005910	short chain dehydrogenase; Provisional; Region: PRK08303
1127134005911	NAD(P) binding site [chemical binding]; other site
1127134005912	active site
1127134005913	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1127134005914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1127134005915	transcription termination factor Rho; Provisional; Region: PRK12608
1127134005916	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1127134005917	RNA binding site [nucleotide binding]; other site
1127134005918	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1127134005919	Walker A motif; other site
1127134005920	ATP binding site [chemical binding]; other site
1127134005921	Walker B motif; other site
1127134005922	HEAT repeats; Region: HEAT_2; pfam13646
1127134005923	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1127134005924	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134005925	DNA binding residues [nucleotide binding]
1127134005926	putative dimer interface [polypeptide binding]; other site
1127134005927	HEAT repeats; Region: HEAT_2; pfam13646
1127134005928	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134005929	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134005930	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134005931	DoxX-like family; Region: DoxX_2; pfam13564
1127134005932	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1127134005933	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1127134005934	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1127134005935	nucleotide binding site [chemical binding]; other site
1127134005936	ethanolamine-phosphate cytidylyltransferase; Provisional; Region: PTZ00308
1127134005937	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134005938	active site
1127134005939	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1127134005940	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1127134005941	active site
1127134005942	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134005943	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134005944	active site
1127134005945	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1127134005946	classical (c) SDRs; Region: SDR_c; cd05233
1127134005947	NAD(P) binding site [chemical binding]; other site
1127134005948	active site
1127134005949	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1127134005950	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134005951	putative active site [active]
1127134005952	putative substrate binding site [chemical binding]; other site
1127134005953	ATP binding site [chemical binding]; other site
1127134005954	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1127134005955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134005956	NAD(P) binding site [chemical binding]; other site
1127134005957	active site
1127134005958	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134005959	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134005960	active site
1127134005961	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134005962	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1127134005963	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134005964	active site
1127134005965	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134005966	active site
1127134005967	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134005968	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1127134005969	NAD(P) binding site [chemical binding]; other site
1127134005970	epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247
1127134005971	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134005972	motif II; other site
1127134005973	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134005974	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134005975	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1127134005976	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1127134005977	acyl-activating enzyme (AAE) consensus motif; other site
1127134005978	putative AMP binding site [chemical binding]; other site
1127134005979	putative active site [active]
1127134005980	putative CoA binding site [chemical binding]; other site
1127134005981	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134005982	metabolite-proton symporter; Region: 2A0106; TIGR00883
1127134005983	putative substrate translocation pore; other site
1127134005984	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
1127134005985	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134005986	dimer interface [polypeptide binding]; other site
1127134005987	active site
1127134005988	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
1127134005989	putative active site [active]
1127134005990	putative catalytic site [active]
1127134005991	Secretory lipase; Region: LIP; pfam03583
1127134005992	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1127134005993	classical (c) SDRs; Region: SDR_c; cd05233
1127134005994	NAD(P) binding site [chemical binding]; other site
1127134005995	active site
1127134005996	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
1127134005997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134005998	motif II; other site
1127134005999	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1127134006000	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1127134006001	trimer interface [polypeptide binding]; other site
1127134006002	active site
1127134006003	substrate binding site [chemical binding]; other site
1127134006004	CoA binding site [chemical binding]; other site
1127134006005	Predicted membrane protein [Function unknown]; Region: COG2364
1127134006006	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1127134006007	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1127134006008	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
1127134006009	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1127134006010	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006011	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006012	enoyl-CoA hydratase; Provisional; Region: PRK12478
1127134006013	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134006014	substrate binding site [chemical binding]; other site
1127134006015	oxyanion hole (OAH) forming residues; other site
1127134006016	trimer interface [polypeptide binding]; other site
1127134006017	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134006018	AAA domain; Region: AAA_32; pfam13654
1127134006019	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1127134006020	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1127134006021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134006022	Walker A/P-loop; other site
1127134006023	ATP binding site [chemical binding]; other site
1127134006024	Q-loop/lid; other site
1127134006025	ABC transporter signature motif; other site
1127134006026	Walker B; other site
1127134006027	D-loop; other site
1127134006028	H-loop/switch region; other site
1127134006029	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134006030	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134006031	DNA binding residues [nucleotide binding]
1127134006032	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134006033	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134006034	DNA binding residues [nucleotide binding]
1127134006035	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1127134006036	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134006037	Coenzyme A binding pocket [chemical binding]; other site
1127134006038	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1127134006039	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1127134006040	putative DNA binding site [nucleotide binding]; other site
1127134006041	putative homodimer interface [polypeptide binding]; other site
1127134006042	lycopene cyclase family protein; Region: carotene-cycl; TIGR01790
1127134006043	lycopene cyclase; Region: lycopene_cycl; TIGR01789
1127134006044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006046	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1127134006047	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006048	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1127134006049	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134006050	Cytochrome P450; Region: p450; cl12078
1127134006051	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134006052	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1127134006053	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1127134006054	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
1127134006055	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
1127134006056	Part of AAA domain; Region: AAA_19; pfam13245
1127134006057	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1127134006058	exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447
1127134006059	AAA domain; Region: AAA_30; pfam13604
1127134006060	Family description; Region: UvrD_C_2; pfam13538
1127134006061	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1127134006062	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134006063	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134006064	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134006065	DNA binding residues [nucleotide binding]
1127134006066	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134006067	MMPL family; Region: MMPL; pfam03176
1127134006068	MMPL family; Region: MMPL; pfam03176
1127134006069	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006070	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
1127134006071	NAD(P) binding site [chemical binding]; other site
1127134006072	active site
1127134006073	peptide synthase; Provisional; Region: PRK09274
1127134006074	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
1127134006075	acyl-activating enzyme (AAE) consensus motif; other site
1127134006076	putative AMP binding site [chemical binding]; other site
1127134006077	putative active site [active]
1127134006078	putative CoA binding site [chemical binding]; other site
1127134006079	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134006080	active site
1127134006081	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
1127134006082	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134006083	active site
1127134006084	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1127134006085	DNA-binding interface [nucleotide binding]; DNA binding site
1127134006086	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006087	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
1127134006088	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
1127134006089	NAD(P) binding site [chemical binding]; other site
1127134006090	catalytic residues [active]
1127134006091	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1127134006092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006093	NAD(P) binding site [chemical binding]; other site
1127134006094	active site
1127134006095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1127134006096	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1127134006097	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1127134006098	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1127134006099	putative active site [active]
1127134006100	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
1127134006101	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1127134006102	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1127134006103	homodimer interface [polypeptide binding]; other site
1127134006104	NADP binding site [chemical binding]; other site
1127134006105	substrate binding site [chemical binding]; other site
1127134006106	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134006107	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1127134006108	Domain of unknown function (DUF222); Region: DUF222; pfam02720
1127134006109	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1127134006110	active site
1127134006111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134006112	active site
1127134006113	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1127134006114	TrkA-C domain; Region: TrkA_C; pfam02080
1127134006115	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1127134006116	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1127134006117	EspG family; Region: ESX-1_EspG; pfam14011
1127134006118	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134006119	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134006120	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134006121	putative metal binding site [ion binding]; other site
1127134006122	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1127134006123	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134006124	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1127134006125	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1127134006126	metabolite-proton symporter; Region: 2A0106; TIGR00883
1127134006127	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006128	putative substrate translocation pore; other site
1127134006129	probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560
1127134006130	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134006131	acyl-CoA synthetase; Validated; Region: PRK07788
1127134006132	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134006133	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1127134006134	acyl-activating enzyme (AAE) consensus motif; other site
1127134006135	acyl-activating enzyme (AAE) consensus motif; other site
1127134006136	putative AMP binding site [chemical binding]; other site
1127134006137	putative active site [active]
1127134006138	putative CoA binding site [chemical binding]; other site
1127134006139	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1127134006140	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1127134006141	putative active site [active]
1127134006142	putative metal binding site [ion binding]; other site
1127134006143	acyltransferase PapA5; Provisional; Region: PRK09294
1127134006144	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1127134006145	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1127134006146	FAD binding pocket [chemical binding]; other site
1127134006147	FAD binding motif [chemical binding]; other site
1127134006148	phosphate binding motif [ion binding]; other site
1127134006149	NAD binding pocket [chemical binding]; other site
1127134006150	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1127134006151	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134006152	Pirin; Region: Pirin; pfam02678
1127134006153	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006154	putative substrate translocation pore; other site
1127134006155	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006156	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1127134006157	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1127134006158	FAD binding pocket [chemical binding]; other site
1127134006159	FAD binding motif [chemical binding]; other site
1127134006160	phosphate binding motif [ion binding]; other site
1127134006161	beta-alpha-beta structure motif; other site
1127134006162	NAD(p) ribose binding residues [chemical binding]; other site
1127134006163	NAD binding pocket [chemical binding]; other site
1127134006164	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1127134006165	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134006166	catalytic loop [active]
1127134006167	iron binding site [ion binding]; other site
1127134006168	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1127134006169	classical (c) SDRs; Region: SDR_c; cd05233
1127134006170	NAD(P) binding site [chemical binding]; other site
1127134006171	active site
1127134006172	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1127134006173	classical (c) SDRs; Region: SDR_c; cd05233
1127134006174	NAD(P) binding site [chemical binding]; other site
1127134006175	active site
1127134006176	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
1127134006177	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1127134006178	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006179	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1127134006180	classical (c) SDRs; Region: SDR_c; cd05233
1127134006181	NAD(P) binding site [chemical binding]; other site
1127134006182	active site
1127134006183	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835
1127134006184	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134006185	ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781
1127134006186	dimer interface [polypeptide binding]; other site
1127134006187	active site/substrate binding site [active]
1127134006188	3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837
1127134006189	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134006190	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134006191	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134006192	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1127134006193	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134006194	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134006195	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134006196	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134006197	substrate binding pocket [chemical binding]; other site
1127134006198	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1127134006199	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1127134006200	Bacterial transcriptional regulator; Region: IclR; pfam01614
1127134006201	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
1127134006202	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
1127134006203	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
1127134006204	active site
1127134006205	Fe binding site [ion binding]; other site
1127134006206	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006207	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1127134006208	active site
1127134006209	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1127134006210	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1127134006211	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134006212	hydrophobic ligand binding site; other site
1127134006213	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1127134006214	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
1127134006215	classical (c) SDRs; Region: SDR_c; cd05233
1127134006216	NAD(P) binding site [chemical binding]; other site
1127134006217	active site
1127134006218	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134006219	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134006220	active site 2 [active]
1127134006221	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134006222	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1127134006223	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134006224	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1127134006225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006226	short chain dehydrogenase; Provisional; Region: PRK06181
1127134006227	NAD(P) binding site [chemical binding]; other site
1127134006228	active site
1127134006229	Domain of unknown function (DUF4324); Region: DUF4324; pfam14212
1127134006230	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1127134006231	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134006232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134006233	active site
1127134006234	phosphorylation site [posttranslational modification]
1127134006235	intermolecular recognition site; other site
1127134006236	dimerization interface [polypeptide binding]; other site
1127134006237	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134006238	DNA binding residues [nucleotide binding]
1127134006239	dimerization interface [polypeptide binding]; other site
1127134006240	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1127134006241	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134006242	Histidine kinase; Region: HisKA_3; pfam07730
1127134006243	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134006244	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1127134006245	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1127134006246	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1127134006247	transmembrane helices; other site
1127134006248	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1127134006249	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1127134006250	active site
1127134006251	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1127134006252	arsenical-resistance protein; Region: acr3; TIGR00832
1127134006253	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134006254	dimerization interface [polypeptide binding]; other site
1127134006255	putative DNA binding site [nucleotide binding]; other site
1127134006256	putative Zn2+ binding site [ion binding]; other site
1127134006257	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1127134006258	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134006259	DNA binding residues [nucleotide binding]
1127134006260	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1127134006261	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1127134006262	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1127134006263	Domain of unknown function DUF21; Region: DUF21; pfam01595
1127134006264	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1127134006265	Transporter associated domain; Region: CorC_HlyC; pfam03471
1127134006266	Domain of unknown function DUF21; Region: DUF21; pfam01595
1127134006267	FOG: CBS domain [General function prediction only]; Region: COG0517
1127134006268	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1127134006269	short chain dehydrogenase; Provisional; Region: PRK12744
1127134006270	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1127134006271	NADP binding site [chemical binding]; other site
1127134006272	homodimer interface [polypeptide binding]; other site
1127134006273	active site
1127134006274	substrate binding site [chemical binding]; other site
1127134006275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134006276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134006277	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1127134006278	dimerization interface [polypeptide binding]; other site
1127134006279	substrate binding pocket [chemical binding]; other site
1127134006280	short chain dehydrogenase; Provisional; Region: PRK06701
1127134006281	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006282	NAD(P) binding site [chemical binding]; other site
1127134006283	active site
1127134006284	Glucose dehydrogenase; Region: glucose_DH; cd08230
1127134006285	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1127134006286	NADP binding site [chemical binding]; other site
1127134006287	catalytic Zn binding site [ion binding]; other site
1127134006288	structural Zn binding site [ion binding]; other site
1127134006289	dimer interface [polypeptide binding]; other site
1127134006290	ChaB; Region: ChaB; pfam06150
1127134006291	CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704
1127134006292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1127134006293	putative methyltransferase; Provisional; Region: PRK14967
1127134006294	S-adenosylmethionine binding site [chemical binding]; other site
1127134006295	Glyco_18 domain; Region: Glyco_18; smart00636
1127134006296	succinic semialdehyde dehydrogenase; Region: PLN02278
1127134006297	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1127134006298	tetramerization interface [polypeptide binding]; other site
1127134006299	NAD(P) binding site [chemical binding]; other site
1127134006300	catalytic residues [active]
1127134006301	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1127134006302	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1127134006303	NAD(P) binding site [chemical binding]; other site
1127134006304	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1127134006305	GAF domain; Region: GAF; pfam01590
1127134006306	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1127134006307	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134006308	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1127134006309	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006310	NAD(P) binding site [chemical binding]; other site
1127134006311	active site
1127134006312	short chain dehydrogenase; Provisional; Region: PRK05872
1127134006313	classical (c) SDRs; Region: SDR_c; cd05233
1127134006314	NAD(P) binding site [chemical binding]; other site
1127134006315	active site
1127134006316	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134006317	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134006318	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1127134006319	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1127134006320	FMN-binding pocket [chemical binding]; other site
1127134006321	flavin binding motif; other site
1127134006322	phosphate binding motif [ion binding]; other site
1127134006323	beta-alpha-beta structure motif; other site
1127134006324	NAD binding pocket [chemical binding]; other site
1127134006325	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134006326	catalytic loop [active]
1127134006327	iron binding site [ion binding]; other site
1127134006328	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1127134006329	Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118
1127134006330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006332	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1127134006333	hydrophobic ligand binding site; other site
1127134006334	acetyl-CoA acetyltransferase; Validated; Region: PRK08257
1127134006335	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134006336	active site
1127134006337	enoyl-CoA hydratase; Provisional; Region: PRK08252
1127134006338	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134006339	substrate binding site [chemical binding]; other site
1127134006340	oxyanion hole (OAH) forming residues; other site
1127134006341	trimer interface [polypeptide binding]; other site
1127134006342	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134006343	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134006344	helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422
1127134006345	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134006346	DNA binding residues [nucleotide binding]
1127134006347	high affinity sulphate transporter 1; Region: sulP; TIGR00815
1127134006348	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1127134006349	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1127134006350	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1127134006351	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1127134006352	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1127134006353	DXD motif; other site
1127134006354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006355	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1127134006356	NAD(P) binding site [chemical binding]; other site
1127134006357	active site
1127134006358	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1127134006359	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1127134006360	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1127134006361	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1127134006362	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1127134006363	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
1127134006364	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134006365	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1127134006366	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134006367	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134006368	DNA binding residues [nucleotide binding]
1127134006369	dimerization interface [polypeptide binding]; other site
1127134006370	Domain of unknown function (DUF389); Region: DUF389; pfam04087
1127134006371	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1127134006372	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1127134006373	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1127134006374	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1127134006375	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1127134006376	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1127134006377	Putative esterase; Region: Esterase; pfam00756
1127134006378	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1127134006379	Protein export membrane protein; Region: SecD_SecF; cl14618
1127134006380	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1127134006381	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1127134006382	active site
1127134006383	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1127134006384	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1127134006385	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006386	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1127134006387	Enoylreductase; Region: PKS_ER; smart00829
1127134006388	NAD(P) binding site [chemical binding]; other site
1127134006389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006390	KR domain; Region: KR; pfam08659
1127134006391	NAD(P) binding site [chemical binding]; other site
1127134006392	active site
1127134006393	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134006394	Condensation domain; Region: Condensation; pfam00668
1127134006395	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
1127134006396	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006397	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134006398	putative substrate translocation pore; other site
1127134006399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006400	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1127134006401	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134006402	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134006403	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1127134006404	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1127134006405	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1127134006406	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
1127134006407	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1127134006408	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1127134006409	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
1127134006410	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1127134006411	active site
1127134006412	catalytic triad [active]
1127134006413	oxyanion hole [active]
1127134006414	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134006415	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1127134006416	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1127134006417	The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH).  The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531
1127134006418	LGFP repeat; Region: LGFP; pfam08310
1127134006419	LGFP repeat; Region: LGFP; pfam08310
1127134006420	Dodecin; Region: Dodecin; pfam07311
1127134006421	hypothetical protein; Provisional; Region: PRK07877
1127134006422	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1127134006423	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134006424	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134006425	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1127134006426	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006428	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1127134006429	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1127134006430	[4Fe-4S] binding site [ion binding]; other site
1127134006431	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134006432	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134006433	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134006434	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1127134006435	molybdopterin cofactor binding site; other site
1127134006436	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1127134006437	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1127134006438	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1127134006439	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
1127134006440	L-aspartate oxidase; Provisional; Region: PRK06175
1127134006441	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1127134006442	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1127134006443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1127134006444	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1127134006445	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134006446	DNA-binding site [nucleotide binding]; DNA binding site
1127134006447	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1127134006448	UTRA domain; Region: UTRA; pfam07702
1127134006449	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006450	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006451	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1127134006452	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1127134006453	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006454	active site
1127134006455	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1127134006456	RibD C-terminal domain; Region: RibD_C; cl17279
1127134006457	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
1127134006458	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
1127134006459	CysD dimerization site [polypeptide binding]; other site
1127134006460	G1 box; other site
1127134006461	putative GEF interaction site [polypeptide binding]; other site
1127134006462	GTP/Mg2+ binding site [chemical binding]; other site
1127134006463	Switch I region; other site
1127134006464	G2 box; other site
1127134006465	G3 box; other site
1127134006466	Switch II region; other site
1127134006467	G4 box; other site
1127134006468	G5 box; other site
1127134006469	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
1127134006470	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
1127134006471	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1127134006472	ligand-binding site [chemical binding]; other site
1127134006473	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
1127134006474	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1127134006475	Active Sites [active]
1127134006476	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1127134006477	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1127134006478	short chain dehydrogenase; Provisional; Region: PRK07890
1127134006479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006480	NAD(P) binding site [chemical binding]; other site
1127134006481	active site
1127134006482	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
1127134006483	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134006484	CoenzymeA binding site [chemical binding]; other site
1127134006485	subunit interaction site [polypeptide binding]; other site
1127134006486	PHB binding site; other site
1127134006487	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134006488	hydrophobic ligand binding site; other site
1127134006489	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134006490	Cytochrome P450; Region: p450; cl12078
1127134006491	DinB superfamily; Region: DinB_2; pfam12867
1127134006492	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1127134006493	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1127134006494	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134006495	Walker A/P-loop; other site
1127134006496	ATP binding site [chemical binding]; other site
1127134006497	Q-loop/lid; other site
1127134006498	ABC transporter signature motif; other site
1127134006499	Walker B; other site
1127134006500	D-loop; other site
1127134006501	H-loop/switch region; other site
1127134006502	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1127134006503	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134006504	DNA-binding site [nucleotide binding]; DNA binding site
1127134006505	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1127134006506	2-isopropylmalate synthase; Validated; Region: PRK03739
1127134006507	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1127134006508	active site
1127134006509	catalytic residues [active]
1127134006510	metal binding site [ion binding]; metal-binding site
1127134006511	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1127134006512	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1127134006513	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134006514	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134006515	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1127134006516	catalytic residues [active]
1127134006517	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134006518	S-adenosylmethionine binding site [chemical binding]; other site
1127134006519	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134006520	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134006521	active site
1127134006522	ATP binding site [chemical binding]; other site
1127134006523	substrate binding site [chemical binding]; other site
1127134006524	activation loop (A-loop); other site
1127134006525	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1127134006526	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1127134006527	Bacterial transcriptional regulator; Region: IclR; pfam01614
1127134006528	Cutinase; Region: Cutinase; pfam01083
1127134006529	short chain dehydrogenase; Provisional; Region: PRK07201
1127134006530	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006531	NAD(P) binding site [chemical binding]; other site
1127134006532	active site
1127134006533	classical (c) SDRs; Region: SDR_c; cd05233
1127134006534	NAD(P) binding site [chemical binding]; other site
1127134006535	active site
1127134006536	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1127134006537	heme binding pocket [chemical binding]; other site
1127134006538	heme ligand [chemical binding]; other site
1127134006539	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1127134006540	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1127134006541	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1127134006542	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134006543	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006544	active site
1127134006545	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
1127134006546	active site
1127134006547	Nuclease-related domain; Region: NERD; pfam08378
1127134006548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1127134006549	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1127134006550	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1127134006551	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1127134006552	lipoyl attachment site [posttranslational modification]; other site
1127134006553	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134006554	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134006555	phosphopeptide binding site; other site
1127134006556	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1127134006557	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134006558	DNA binding residues [nucleotide binding]
1127134006559	dimer interface [polypeptide binding]; other site
1127134006560	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1127134006561	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1127134006562	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134006563	DNA binding residues [nucleotide binding]
1127134006564	putative dimer interface [polypeptide binding]; other site
1127134006565	glycine dehydrogenase; Provisional; Region: PRK05367
1127134006566	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1127134006567	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134006568	tetramer interface [polypeptide binding]; other site
1127134006569	catalytic residue [active]
1127134006570	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1127134006571	tetramer interface [polypeptide binding]; other site
1127134006572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134006573	catalytic residue [active]
1127134006574	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006575	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006576	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
1127134006577	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1127134006578	metal ion-dependent adhesion site (MIDAS); other site
1127134006579	Transcription factor WhiB; Region: Whib; pfam02467
1127134006580	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1127134006581	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1127134006582	active site
1127134006583	Electron transfer DM13; Region: DM13; pfam10517
1127134006584	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134006585	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006586	active site
1127134006587	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134006588	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006589	active site
1127134006590	Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728
1127134006591	active site
1127134006592	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006594	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134006595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134006596	Walker A/P-loop; other site
1127134006597	ATP binding site [chemical binding]; other site
1127134006598	Q-loop/lid; other site
1127134006599	ABC transporter signature motif; other site
1127134006600	Walker B; other site
1127134006601	D-loop; other site
1127134006602	H-loop/switch region; other site
1127134006603	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134006604	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134006605	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134006606	Walker A/P-loop; other site
1127134006607	ATP binding site [chemical binding]; other site
1127134006608	Q-loop/lid; other site
1127134006609	ABC transporter signature motif; other site
1127134006610	Walker B; other site
1127134006611	D-loop; other site
1127134006612	H-loop/switch region; other site
1127134006613	salicylate synthase; Region: salicyl_syn; TIGR03494
1127134006614	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1127134006615	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134006616	Cytochrome P450; Region: p450; cl12078
1127134006617	O-methyltransferase; Region: Methyltransf_2; pfam00891
1127134006618	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1127134006619	Condensation domain; Region: Condensation; pfam00668
1127134006620	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1127134006621	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1127134006622	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134006623	acyl-activating enzyme (AAE) consensus motif; other site
1127134006624	AMP binding site [chemical binding]; other site
1127134006625	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134006626	Condensation domain; Region: Condensation; pfam00668
1127134006627	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134006628	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1127134006629	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1127134006630	acyl-activating enzyme (AAE) consensus motif; other site
1127134006631	AMP binding site [chemical binding]; other site
1127134006632	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134006633	Condensation domain; Region: Condensation; pfam00668
1127134006634	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134006635	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1127134006636	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1127134006637	acyl-activating enzyme (AAE) consensus motif; other site
1127134006638	AMP binding site [chemical binding]; other site
1127134006639	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134006640	Condensation domain; Region: Condensation; pfam00668
1127134006641	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134006642	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1127134006643	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1127134006644	acyl-activating enzyme (AAE) consensus motif; other site
1127134006645	AMP binding site [chemical binding]; other site
1127134006646	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134006647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134006648	S-adenosylmethionine binding site [chemical binding]; other site
1127134006649	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134006650	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134006651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006652	NAD(P) binding site [chemical binding]; other site
1127134006653	thiazolinyl imide reductase; Region: thiaz-red; TIGR01761
1127134006654	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1127134006655	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134006656	Cytochrome P450; Region: p450; cl12078
1127134006657	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134006658	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134006659	S-adenosylmethionine binding site [chemical binding]; other site
1127134006660	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134006661	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134006662	putative substrate translocation pore; other site
1127134006663	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134006664	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1127134006665	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1127134006666	active site
1127134006667	cosubstrate binding site; other site
1127134006668	substrate binding site [chemical binding]; other site
1127134006669	catalytic site [active]
1127134006670	C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701
1127134006671	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134006672	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134006673	substrate binding site [chemical binding]; other site
1127134006674	oxyanion hole (OAH) forming residues; other site
1127134006675	trimer interface [polypeptide binding]; other site
1127134006676	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1127134006677	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1127134006678	Uncharacterized conserved protein [Function unknown]; Region: COG5276
1127134006679	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134006680	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006681	active site
1127134006682	Secretory lipase; Region: LIP; pfam03583
1127134006683	Uncharacterized conserved protein [Function unknown]; Region: COG5361
1127134006684	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
1127134006685	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
1127134006686	Domain of unknown function DUF21; Region: DUF21; pfam01595
1127134006687	FOG: CBS domain [General function prediction only]; Region: COG0517
1127134006688	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1127134006689	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1127134006690	Domain of unknown function DUF21; Region: DUF21; pfam01595
1127134006691	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1127134006692	Transporter associated domain; Region: CorC_HlyC; smart01091
1127134006693	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807
1127134006694	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
1127134006695	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1127134006696	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1127134006697	active site
1127134006698	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1127134006699	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1127134006700	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1127134006701	ATP binding site [chemical binding]; other site
1127134006702	putative Mg++ binding site [ion binding]; other site
1127134006703	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134006704	nucleotide binding region [chemical binding]; other site
1127134006705	ATP-binding site [chemical binding]; other site
1127134006706	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1127134006707	Predicted transcriptional regulator [Transcription]; Region: COG3682
1127134006708	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1127134006709	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1127134006710	Walker A/P-loop; other site
1127134006711	ATP binding site [chemical binding]; other site
1127134006712	Q-loop/lid; other site
1127134006713	ABC transporter signature motif; other site
1127134006714	Walker B; other site
1127134006715	D-loop; other site
1127134006716	H-loop/switch region; other site
1127134006717	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1127134006718	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1127134006719	ABC-ATPase subunit  interface; other site
1127134006720	dimer interface [polypeptide binding]; other site
1127134006721	putative PBP binding regions; other site
1127134006722	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1127134006723	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1127134006724	ABC-ATPase subunit  interface; other site
1127134006725	dimer interface [polypeptide binding]; other site
1127134006726	putative PBP binding regions; other site
1127134006727	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134006728	CoenzymeA binding site [chemical binding]; other site
1127134006729	subunit interaction site [polypeptide binding]; other site
1127134006730	PHB binding site; other site
1127134006731	MMPL family; Region: MMPL; pfam03176
1127134006732	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1127134006733	classical (c) SDRs; Region: SDR_c; cd05233
1127134006734	NAD(P) binding site [chemical binding]; other site
1127134006735	active site
1127134006736	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1127134006737	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134006738	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134006739	Walker A/P-loop; other site
1127134006740	ATP binding site [chemical binding]; other site
1127134006741	Q-loop/lid; other site
1127134006742	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134006743	ABC transporter signature motif; other site
1127134006744	Walker B; other site
1127134006745	D-loop; other site
1127134006746	ABC transporter; Region: ABC_tran_2; pfam12848
1127134006747	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134006748	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
1127134006749	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134006750	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1127134006751	active site
1127134006752	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006753	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006754	aconitate hydratase; Validated; Region: PRK09277
1127134006755	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1127134006756	substrate binding site [chemical binding]; other site
1127134006757	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
1127134006758	ligand binding site [chemical binding]; other site
1127134006759	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1127134006760	substrate binding site [chemical binding]; other site
1127134006761	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134006762	NlpC/P60 family; Region: NLPC_P60; pfam00877
1127134006763	MoxR-like ATPases [General function prediction only]; Region: COG0714
1127134006764	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134006765	Walker A motif; other site
1127134006766	ATP binding site [chemical binding]; other site
1127134006767	Walker B motif; other site
1127134006768	arginine finger; other site
1127134006769	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1127134006770	Protein of unknown function DUF58; Region: DUF58; pfam01882
1127134006771	hypothetical protein; Provisional; Region: PRK13685
1127134006772	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1127134006773	metal ion-dependent adhesion site (MIDAS); other site
1127134006774	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1127134006775	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1127134006776	NAD(P) binding site [chemical binding]; other site
1127134006777	homotetramer interface [polypeptide binding]; other site
1127134006778	homodimer interface [polypeptide binding]; other site
1127134006779	active site
1127134006780	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889
1127134006781	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006782	NAD(P) binding site [chemical binding]; other site
1127134006783	active site
1127134006784	ferrochelatase; Reviewed; Region: hemH; PRK00035
1127134006785	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1127134006786	C-terminal domain interface [polypeptide binding]; other site
1127134006787	active site
1127134006788	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1127134006789	active site
1127134006790	N-terminal domain interface [polypeptide binding]; other site
1127134006791	Protein of unknown function (DUF3097); Region: DUF3097; pfam11296
1127134006792	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1127134006793	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1127134006794	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1127134006795	SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830
1127134006796	active site
1127134006797	catalytic triad [active]
1127134006798	oxyanion hole [active]
1127134006799	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1127134006800	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1127134006801	protein binding site [polypeptide binding]; other site
1127134006802	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1127134006803	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1127134006804	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
1127134006805	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
1127134006806	heterodimer interface [polypeptide binding]; other site
1127134006807	substrate interaction site [chemical binding]; other site
1127134006808	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1127134006809	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1127134006810	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1127134006811	active site
1127134006812	substrate binding site [chemical binding]; other site
1127134006813	coenzyme B12 binding site [chemical binding]; other site
1127134006814	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1127134006815	B12 binding site [chemical binding]; other site
1127134006816	cobalt ligand [ion binding]; other site
1127134006817	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1127134006818	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1127134006819	GTP/Mg2+ binding site [chemical binding]; other site
1127134006820	G5 box; other site
1127134006821	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1127134006822	Walker A; other site
1127134006823	G1 box; other site
1127134006824	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1127134006825	active site
1127134006826	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
1127134006827	active site
1127134006828	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1127134006829	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1127134006830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006831	NAD(P) binding site [chemical binding]; other site
1127134006832	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134006834	active site
1127134006835	active site
1127134006836	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134006837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006839	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134006840	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134006841	active site
1127134006842	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006843	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1127134006844	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1127134006845	conserved cys residue [active]
1127134006846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134006847	Isochorismatase family; Region: Isochorismatase; pfam00857
1127134006848	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1127134006849	catalytic triad [active]
1127134006850	conserved cis-peptide bond; other site
1127134006851	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1127134006852	nucleotide binding site [chemical binding]; other site
1127134006853	ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224
1127134006854	Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905
1127134006855	active site
1127134006856	DNA binding site [nucleotide binding]
1127134006857	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970
1127134006858	DNA binding site [nucleotide binding]
1127134006859	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1127134006860	DNA-binding site [nucleotide binding]; DNA binding site
1127134006861	RNA-binding motif; other site
1127134006862	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1127134006863	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006864	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006865	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134006866	MMPL family; Region: MMPL; pfam03176
1127134006867	MMPL family; Region: MMPL; pfam03176
1127134006868	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1127134006869	active site
1127134006870	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1127134006871	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1127134006872	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134006873	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134006874	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134006875	CoenzymeA binding site [chemical binding]; other site
1127134006876	subunit interaction site [polypeptide binding]; other site
1127134006877	PHB binding site; other site
1127134006878	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1127134006879	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1127134006880	active site
1127134006881	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1127134006882	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134006883	DNA binding residues [nucleotide binding]
1127134006884	dimer interface [polypeptide binding]; other site
1127134006885	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134006886	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134006887	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1127134006888	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1127134006889	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134006890	catalytic residue [active]
1127134006891	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1127134006892	active site residue [active]
1127134006893	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1127134006894	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1127134006895	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134006896	catalytic residue [active]
1127134006897	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1127134006898	metal-binding site [ion binding]
1127134006899	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1127134006900	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134006901	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134006902	catalytic residue [active]
1127134006903	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1127134006904	FOG: CBS domain [General function prediction only]; Region: COG0517
1127134006905	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1127134006906	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134006907	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134006908	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134006909	non-specific DNA binding site [nucleotide binding]; other site
1127134006910	salt bridge; other site
1127134006911	sequence-specific DNA binding site [nucleotide binding]; other site
1127134006912	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1127134006913	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134006914	NAD(P) binding site [chemical binding]; other site
1127134006915	putative active site [active]
1127134006916	Protein of unknown function (DUF2599); Region: DUF2599; pfam10783
1127134006917	Secretory lipase; Region: LIP; pfam03583
1127134006918	Secretory lipase; Region: LIP; pfam03583
1127134006919	Secretory lipase; Region: LIP; pfam03583
1127134006920	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134006921	active site
1127134006922	catalytic site [active]
1127134006923	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1127134006924	active site
1127134006925	catalytic site [active]
1127134006926	Helix-turn-helix domain; Region: HTH_31; pfam13560
1127134006927	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134006928	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134006929	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134006930	Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050
1127134006931	homodimer interface [polypeptide binding]; other site
1127134006932	putative substrate binding pocket [chemical binding]; other site
1127134006933	diiron center [ion binding]; other site
1127134006934	Predicted esterase [General function prediction only]; Region: COG0627
1127134006935	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134006936	active site
1127134006937	catalytic site [active]
1127134006938	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134006939	active site 2 [active]
1127134006940	active site 1 [active]
1127134006941	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1127134006942	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1127134006943	putative active site [active]
1127134006944	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1127134006945	Lipase (class 2); Region: Lipase_2; pfam01674
1127134006946	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1127134006947	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1127134006948	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1127134006949	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1127134006950	NAD(P) binding site [chemical binding]; other site
1127134006951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134006952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134006953	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423
1127134006954	putative dimerization interface [polypeptide binding]; other site
1127134006955	Putative esterase; Region: Esterase; pfam00756
1127134006956	Acid Phosphatase; Region: Acid_PPase; cl17256
1127134006957	choline dehydrogenase; Validated; Region: PRK02106
1127134006958	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134006959	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1127134006960	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134006961	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134006962	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1127134006963	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134006964	DNA binding residues [nucleotide binding]
1127134006965	dimer interface [polypeptide binding]; other site
1127134006966	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006967	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134006968	Predicted acyl esterases [General function prediction only]; Region: COG2936
1127134006969	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134006970	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1127134006971	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1127134006972	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1127134006973	Coenzyme A binding pocket [chemical binding]; other site
1127134006974	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1127134006975	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1127134006976	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1127134006977	beta-galactosidase; Region: BGL; TIGR03356
1127134006978	amidase; Provisional; Region: PRK06170
1127134006979	Amidase; Region: Amidase; pfam01425
1127134006980	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134006981	active site
1127134006982	DNA binding site [nucleotide binding]
1127134006983	Int/Topo IB signature motif; other site
1127134006984	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1127134006985	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134006986	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134006987	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134006988	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1127134006989	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134006990	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134006991	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134006992	DNA binding residues [nucleotide binding]
1127134006993	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1127134006994	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901
1127134006995	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134006996	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134006997	S-adenosylmethionine binding site [chemical binding]; other site
1127134006998	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134006999	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007000	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1127134007001	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1127134007002	Di-iron ligands [ion binding]; other site
1127134007003	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1127134007004	Rubredoxin; Region: Rubredoxin; pfam00301
1127134007005	iron binding site [ion binding]; other site
1127134007006	Rubredoxin [Energy production and conversion]; Region: COG1773
1127134007007	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1127134007008	iron binding site [ion binding]; other site
1127134007009	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1127134007010	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134007011	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1127134007012	hypothetical protein; Provisional; Region: PRK07236
1127134007013	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1127134007014	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134007015	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1127134007016	CGNR zinc finger; Region: zf-CGNR; pfam11706
1127134007017	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1127134007018	active site
1127134007019	catalytic triad [active]
1127134007020	oxyanion hole [active]
1127134007021	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
1127134007022	SnoaL-like domain; Region: SnoaL_3; pfam13474
1127134007023	Predicted flavoprotein [General function prediction only]; Region: COG0431
1127134007024	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134007025	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134007026	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1127134007027	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134007028	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134007029	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1127134007030	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1127134007031	active site
1127134007032	catalytic residues [active]
1127134007033	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1127134007034	D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284
1127134007035	NAD binding site [chemical binding]; other site
1127134007036	substrate binding site [chemical binding]; other site
1127134007037	catalytic Zn binding site [ion binding]; other site
1127134007038	structural Zn binding site [ion binding]; other site
1127134007039	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1127134007040	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1127134007041	dimer interface [polypeptide binding]; other site
1127134007042	active site
1127134007043	heme binding site [chemical binding]; other site
1127134007044	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1127134007045	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1127134007046	metal binding site 2 [ion binding]; metal-binding site
1127134007047	putative DNA binding helix; other site
1127134007048	metal binding site 1 [ion binding]; metal-binding site
1127134007049	dimer interface [polypeptide binding]; other site
1127134007050	structural Zn2+ binding site [ion binding]; other site
1127134007051	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1127134007052	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134007053	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1127134007054	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134007055	Walker A/P-loop; other site
1127134007056	ATP binding site [chemical binding]; other site
1127134007057	Q-loop/lid; other site
1127134007058	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134007059	ABC transporter signature motif; other site
1127134007060	Walker B; other site
1127134007061	D-loop; other site
1127134007062	H-loop/switch region; other site
1127134007063	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134007064	Walker A/P-loop; other site
1127134007065	ATP binding site [chemical binding]; other site
1127134007066	Q-loop/lid; other site
1127134007067	ABC transporter signature motif; other site
1127134007068	Walker B; other site
1127134007069	D-loop; other site
1127134007070	H-loop/switch region; other site
1127134007071	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1127134007072	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134007073	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134007074	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134007075	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134007076	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1127134007077	glycerol kinase; Provisional; Region: glpK; PRK00047
1127134007078	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134007079	nucleotide binding site [chemical binding]; other site
1127134007080	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1127134007081	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1127134007082	Bacterial transcriptional regulator; Region: IclR; pfam01614
1127134007083	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134007084	glycerol kinase; Region: glycerol_kin; TIGR01311
1127134007085	nucleotide binding site [chemical binding]; other site
1127134007086	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1127134007087	Lipase (class 2); Region: Lipase_2; pfam01674
1127134007088	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134007089	Cytochrome P450; Region: p450; cl12078
1127134007090	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134007091	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134007092	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1127134007093	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007094	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007095	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134007096	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134007097	substrate binding site [chemical binding]; other site
1127134007098	oxyanion hole (OAH) forming residues; other site
1127134007099	trimer interface [polypeptide binding]; other site
1127134007100	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1127134007101	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1127134007102	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1127134007103	Walker A/P-loop; other site
1127134007104	ATP binding site [chemical binding]; other site
1127134007105	Q-loop/lid; other site
1127134007106	ABC transporter signature motif; other site
1127134007107	Walker B; other site
1127134007108	D-loop; other site
1127134007109	H-loop/switch region; other site
1127134007110	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1127134007111	dimer interface [polypeptide binding]; other site
1127134007112	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1127134007113	putative PBP binding regions; other site
1127134007114	ABC-ATPase subunit  interface; other site
1127134007115	ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558
1127134007116	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1127134007117	intersubunit interface [polypeptide binding]; other site
1127134007118	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134007119	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134007120	active site
1127134007121	catalytic tetrad [active]
1127134007122	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
1127134007123	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134007124	catalytic core [active]
1127134007125	Protein of unknown function (DUF3090); Region: DUF3090; pfam11290
1127134007126	conserved hypothetical protein; Region: TIGR03843
1127134007127	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134007128	cysteinyl-tRNA synthetase; Provisional; Region: PRK12418
1127134007129	active site
1127134007130	HIGH motif; other site
1127134007131	nucleotide binding site [chemical binding]; other site
1127134007132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134007133	active site
1127134007134	KMSKS motif; other site
1127134007135	Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955
1127134007136	putative tRNA binding surface [nucleotide binding]; other site
1127134007137	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134007138	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134007139	active site
1127134007140	catalytic site [active]
1127134007141	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1127134007142	active site
1127134007143	catalytic site [active]
1127134007144	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
1127134007145	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1127134007146	putative active site [active]
1127134007147	MMPL family; Region: MMPL; pfam03176
1127134007148	MMPL family; Region: MMPL; pfam03176
1127134007149	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1127134007150	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1127134007151	quinone interaction residues [chemical binding]; other site
1127134007152	active site
1127134007153	catalytic residues [active]
1127134007154	FMN binding site [chemical binding]; other site
1127134007155	substrate binding site [chemical binding]; other site
1127134007156	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1127134007157	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1127134007158	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
1127134007159	dimerization interface [polypeptide binding]; other site
1127134007160	active site
1127134007161	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1127134007162	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1127134007163	acyl-activating enzyme (AAE) consensus motif; other site
1127134007164	putative AMP binding site [chemical binding]; other site
1127134007165	putative active site [active]
1127134007166	putative CoA binding site [chemical binding]; other site
1127134007167	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1127134007168	substrate binding site [chemical binding]; other site
1127134007169	hypothetical protein; Provisional; Region: PRK07906
1127134007170	M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675
1127134007171	putative metal binding site [ion binding]; other site
1127134007172	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1127134007173	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134007174	S-adenosylmethionine binding site [chemical binding]; other site
1127134007175	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
1127134007176	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
1127134007177	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1127134007178	active site
1127134007179	NTP binding site [chemical binding]; other site
1127134007180	metal binding triad [ion binding]; metal-binding site
1127134007181	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134007182	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134007183	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1127134007184	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1127134007185	glutamate dehydrogenase; Provisional; Region: PRK09414
1127134007186	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1127134007187	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1127134007188	NAD(P) binding site [chemical binding]; other site
1127134007189	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1127134007190	NAD-dependent deacetylase; Provisional; Region: PRK05333
1127134007191	Protein of unknown function DUF72; Region: DUF72; pfam01904
1127134007192	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529
1127134007193	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1127134007194	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1127134007195	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1127134007196	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1127134007197	nucleoside/Zn binding site; other site
1127134007198	dimer interface [polypeptide binding]; other site
1127134007199	catalytic motif [active]
1127134007200	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1127134007201	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134007202	DNA-binding site [nucleotide binding]; DNA binding site
1127134007203	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1127134007204	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1127134007205	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1127134007206	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1127134007207	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1127134007208	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1127134007209	hypothetical protein; Provisional; Region: PRK08317
1127134007210	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134007211	S-adenosylmethionine binding site [chemical binding]; other site
1127134007212	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1127134007213	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134007214	DNA binding residues [nucleotide binding]
1127134007215	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1127134007216	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134007217	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134007218	Amidinotransferase; Region: Amidinotransf; cl12043
1127134007219	Hemerythrin-like domain; Region: Hr-like; cd12108
1127134007220	Fe binding site [ion binding]; other site
1127134007221	Domain of unknown function (DUF4267); Region: DUF4267; pfam14087
1127134007222	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1127134007223	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1127134007224	Predicted ATPase [General function prediction only]; Region: COG3899
1127134007225	AAA ATPase domain; Region: AAA_16; pfam13191
1127134007226	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134007227	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1127134007228	NAD(P) binding site [chemical binding]; other site
1127134007229	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1127134007230	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134007231	acyl-activating enzyme (AAE) consensus motif; other site
1127134007232	AMP binding site [chemical binding]; other site
1127134007233	active site
1127134007234	CoA binding site [chemical binding]; other site
1127134007235	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1127134007236	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007237	NAD(P) binding site [chemical binding]; other site
1127134007238	active site
1127134007239	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1127134007240	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134007241	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1127134007242	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134007243	DNA binding residues [nucleotide binding]
1127134007244	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1127134007245	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1127134007246	proposed catalytic triad [active]
1127134007247	conserved cys residue [active]
1127134007248	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134007249	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134007250	DNA binding residues [nucleotide binding]
1127134007251	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1127134007252	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1127134007253	putative dimer interface [polypeptide binding]; other site
1127134007254	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1127134007255	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1127134007256	Di-iron ligands [ion binding]; other site
1127134007257	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134007258	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134007259	Domain of unknown function (DUF3471); Region: DUF3471; pfam11954
1127134007260	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134007261	MarR family; Region: MarR; pfam01047
1127134007262	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1127134007263	SnoaL-like domain; Region: SnoaL_3; pfam13474
1127134007264	HTH domain; Region: HTH_11; pfam08279
1127134007265	WYL domain; Region: WYL; pfam13280
1127134007266	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1127134007267	homotrimer interaction site [polypeptide binding]; other site
1127134007268	putative active site [active]
1127134007269	Protein of unknown function (DUF419); Region: DUF419; cl15265
1127134007270	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1127134007271	classical (c) SDRs; Region: SDR_c; cd05233
1127134007272	NAD(P) binding site [chemical binding]; other site
1127134007273	active site
1127134007274	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1127134007275	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1127134007276	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1127134007277	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1127134007278	Bacterial transcriptional regulator; Region: IclR; pfam01614
1127134007279	Predicted ATPase [General function prediction only]; Region: COG3903
1127134007280	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007281	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007282	DNA binding residues [nucleotide binding]
1127134007283	dimerization interface [polypeptide binding]; other site
1127134007284	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1127134007285	active site
1127134007286	Int/Topo IB signature motif; other site
1127134007287	catalytic residues [active]
1127134007288	DNA binding site [nucleotide binding]
1127134007289	Protein of unknown function (DUF2637); Region: DUF2637; pfam10935
1127134007290	Helix-turn-helix domain; Region: HTH_38; pfam13936
1127134007291	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
1127134007292	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
1127134007293	active site
1127134007294	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
1127134007295	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
1127134007296	active site
1127134007297	S-adenosylmethionine synthetase [Coenzyme metabolism]; Region: MetK; COG0192
1127134007298	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
1127134007299	polymerase nucleotide-binding site; other site
1127134007300	DNA-binding residues [nucleotide binding]; DNA binding site
1127134007301	nucleotide binding site [chemical binding]; other site
1127134007302	primase nucleotide-binding site [nucleotide binding]; other site
1127134007303	DNA protecting protein DprA; Region: dprA; TIGR00732
1127134007304	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1127134007305	ParB-like nuclease domain; Region: ParB; smart00470
1127134007306	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1127134007307	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1127134007308	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1127134007309	dimer interface [polypeptide binding]; other site
1127134007310	ssDNA binding site [nucleotide binding]; other site
1127134007311	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1127134007312	TrwC relaxase; Region: TrwC; pfam08751
1127134007313	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
1127134007314	Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768
1127134007315	AAA domain; Region: AAA_30; pfam13604
1127134007316	Family description; Region: UvrD_C_2; pfam13538
1127134007317	HTH-like domain; Region: HTH_21; pfam13276
1127134007318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1127134007319	Integrase core domain; Region: rve; pfam00665
1127134007320	Integrase core domain; Region: rve_3; pfam13683
1127134007321	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134007322	DNA binding residues [nucleotide binding]
1127134007323	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1127134007324	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1127134007325	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1127134007326	dsRNA binding site [nucleotide binding]; other site
1127134007327	CHAT domain; Region: CHAT; cl17868
1127134007328	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
1127134007329	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1127134007330	Trp docking motif [polypeptide binding]; other site
1127134007331	active site
1127134007332	PQQ-like domain; Region: PQQ_2; pfam13360
1127134007333	von Willebrand factor type A domain; Region: VWA_2; pfam13519
1127134007334	metal ion-dependent adhesion site (MIDAS); other site
1127134007335	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1127134007336	active site
1127134007337	oxyanion hole [active]
1127134007338	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1127134007339	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1127134007340	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134007341	dimerization interface [polypeptide binding]; other site
1127134007342	putative DNA binding site [nucleotide binding]; other site
1127134007343	putative Zn2+ binding site [ion binding]; other site
1127134007344	Cation efflux family; Region: Cation_efflux; cl00316
1127134007345	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
1127134007346	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1127134007347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134007348	S-adenosylmethionine binding site [chemical binding]; other site
1127134007349	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1127134007350	active site
1127134007351	catalytic residues [active]
1127134007352	DNA binding site [nucleotide binding]
1127134007353	Int/Topo IB signature motif; other site
1127134007354	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1127134007355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134007356	ATP binding site [chemical binding]; other site
1127134007357	Mg2+ binding site [ion binding]; other site
1127134007358	G-X-G motif; other site
1127134007359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007360	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007361	DNA binding residues [nucleotide binding]
1127134007362	dimerization interface [polypeptide binding]; other site
1127134007363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134007364	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1127134007366	active site
1127134007367	phosphorylation site [posttranslational modification]
1127134007368	intermolecular recognition site; other site
1127134007369	dimerization interface [polypeptide binding]; other site
1127134007370	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1127134007371	DNA binding residues [nucleotide binding]
1127134007372	dimerization interface [polypeptide binding]; other site
1127134007373	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1127134007374	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1127134007375	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
1127134007376	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1127134007377	MULE transposase domain; Region: MULE; pfam10551
1127134007378	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134007379	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1127134007380	Walker A/P-loop; other site
1127134007381	ATP binding site [chemical binding]; other site
1127134007382	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1127134007383	putative active site [active]
1127134007384	putative metal-binding site [ion binding]; other site
1127134007385	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134007386	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1127134007387	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134007388	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134007389	Ligand Binding Site [chemical binding]; other site
1127134007390	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1127134007391	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134007392	Ligand Binding Site [chemical binding]; other site
1127134007393	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1127134007394	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
1127134007395	Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025
1127134007396	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134007397	Ligand Binding Site [chemical binding]; other site
1127134007398	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134007399	Ligand Binding Site [chemical binding]; other site
1127134007400	Universal stress protein family; Region: Usp; pfam00582
1127134007401	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1127134007402	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1127134007403	Divalent cation transporter; Region: MgtE; cl00786
1127134007404	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1127134007405	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134007406	Ligand Binding Site [chemical binding]; other site
1127134007407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134007408	Ligand Binding Site [chemical binding]; other site
1127134007409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134007410	motif II; other site
1127134007411	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1127134007412	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1127134007413	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1127134007414	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1127134007415	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1127134007416	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134007417	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134007418	Walker A/P-loop; other site
1127134007419	ATP binding site [chemical binding]; other site
1127134007420	Q-loop/lid; other site
1127134007421	ABC transporter signature motif; other site
1127134007422	Walker B; other site
1127134007423	D-loop; other site
1127134007424	H-loop/switch region; other site
1127134007425	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1127134007426	AAA ATPase domain; Region: AAA_16; pfam13191
1127134007427	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134007428	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1127134007429	binding surface
1127134007430	TPR motif; other site
1127134007431	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134007432	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134007433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134007434	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1127134007435	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1127134007436	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1127134007437	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1127134007438	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1127134007439	ATP binding site [chemical binding]; other site
1127134007440	substrate binding site [chemical binding]; other site
1127134007441	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1127134007442	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1127134007443	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1127134007444	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1127134007445	putative dimer interface [polypeptide binding]; other site
1127134007446	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1127134007447	NAD(P) binding site [chemical binding]; other site
1127134007448	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134007449	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134007450	active site
1127134007451	ATP binding site [chemical binding]; other site
1127134007452	substrate binding site [chemical binding]; other site
1127134007453	activation loop (A-loop); other site
1127134007454	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134007456	active site
1127134007457	phosphorylation site [posttranslational modification]
1127134007458	intermolecular recognition site; other site
1127134007459	dimerization interface [polypeptide binding]; other site
1127134007460	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007461	DNA binding residues [nucleotide binding]
1127134007462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134007463	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134007464	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1127134007465	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1127134007466	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1127134007467	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1127134007468	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1127134007469	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134007470	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134007472	active site
1127134007473	phosphorylation site [posttranslational modification]
1127134007474	intermolecular recognition site; other site
1127134007475	dimerization interface [polypeptide binding]; other site
1127134007476	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007477	DNA binding residues [nucleotide binding]
1127134007478	dimerization interface [polypeptide binding]; other site
1127134007479	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1127134007480	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1127134007481	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134007482	Histidine kinase; Region: HisKA_3; pfam07730
1127134007483	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1127134007484	Domain of unknown function DUF302; Region: DUF302; pfam03625
1127134007485	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
1127134007486	putative homodimer interface [polypeptide binding]; other site
1127134007487	putative homotetramer interface [polypeptide binding]; other site
1127134007488	putative allosteric switch controlling residues; other site
1127134007489	putative metal binding site [ion binding]; other site
1127134007490	putative homodimer-homodimer interface [polypeptide binding]; other site
1127134007491	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1127134007492	Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180
1127134007493	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1127134007494	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1127134007495	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1127134007496	[4Fe-4S] binding site [ion binding]; other site
1127134007497	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134007498	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134007499	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134007500	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1127134007501	molybdopterin cofactor binding site; other site
1127134007502	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134007503	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1127134007504	putative substrate translocation pore; other site
1127134007505	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1127134007506	Domain of unknown function DUF302; Region: DUF302; cl01364
1127134007507	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007508	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1127134007509	NAD(P) binding site [chemical binding]; other site
1127134007510	active site
1127134007511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1127134007512	Predicted kinase [General function prediction only]; Region: COG0645
1127134007513	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1127134007514	active site
1127134007515	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134007516	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1127134007517	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007518	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007519	DNA binding residues [nucleotide binding]
1127134007520	dimerization interface [polypeptide binding]; other site
1127134007521	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1127134007522	DNA binding residues [nucleotide binding]
1127134007523	Cytochrome P450; Region: p450; cl12078
1127134007524	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134007525	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134007526	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
1127134007527	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
1127134007528	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
1127134007529	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
1127134007530	Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of...; Region: HX; cl02471
1127134007531	Metal binding sites [ion binding]; metal-binding site
1127134007532	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
1127134007533	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1127134007534	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007535	NAD(P) binding site [chemical binding]; other site
1127134007536	active site
1127134007537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134007538	S-adenosylmethionine binding site [chemical binding]; other site
1127134007539	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134007540	imidazolonepropionase; Region: hutI; TIGR01224
1127134007541	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
1127134007542	active site
1127134007543	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1127134007544	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1127134007545	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1127134007546	NAD binding site [chemical binding]; other site
1127134007547	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134007548	Cytochrome P450; Region: p450; cl12078
1127134007549	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
1127134007550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134007551	sequence-specific DNA binding site [nucleotide binding]; other site
1127134007552	salt bridge; other site
1127134007553	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1127134007554	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1127134007555	MULE transposase domain; Region: MULE; pfam10551
1127134007556	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134007557	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1127134007558	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
1127134007559	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1127134007560	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134007561	ATP binding site [chemical binding]; other site
1127134007562	putative Mg++ binding site [ion binding]; other site
1127134007563	nucleotide binding region [chemical binding]; other site
1127134007564	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
1127134007565	ATP-binding site [chemical binding]; other site
1127134007566	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
1127134007567	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
1127134007568	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1127134007569	Restriction endonuclease; Region: Mrr_cat; pfam04471
1127134007570	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1127134007571	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1127134007572	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1127134007573	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1127134007574	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1127134007575	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1127134007576	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1127134007577	catalytic residues [active]
1127134007578	catalytic nucleophile [active]
1127134007579	Recombinase; Region: Recombinase; pfam07508
1127134007580	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1127134007581	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134007582	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134007583	active site
1127134007584	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007585	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007586	Competence-damaged protein; Region: CinA; pfam02464
1127134007587	DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685
1127134007588	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1127134007589	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
1127134007590	conserved cys residue [active]
1127134007591	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134007592	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134007593	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134007594	substrate binding pocket [chemical binding]; other site
1127134007595	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134007596	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134007597	Serine hydrolase; Region: Ser_hydrolase; cl17834
1127134007598	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134007599	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134007600	catalytic core [active]
1127134007601	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
1127134007602	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1127134007603	active site
1127134007604	substrate binding site [chemical binding]; other site
1127134007605	Mg2+ binding site [ion binding]; other site
1127134007606	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1127134007607	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1127134007608	Cysteine-rich domain; Region: CCG; pfam02754
1127134007609	Cysteine-rich domain; Region: CCG; pfam02754
1127134007610	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007611	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007612	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1127134007613	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007614	NAD(P) binding site [chemical binding]; other site
1127134007615	active site
1127134007616	enoyl-CoA hydratase; Provisional; Region: PRK05870
1127134007617	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134007618	substrate binding site [chemical binding]; other site
1127134007619	oxyanion hole (OAH) forming residues; other site
1127134007620	trimer interface [polypeptide binding]; other site
1127134007621	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134007622	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134007623	active site
1127134007624	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1127134007625	active site
1127134007626	dimer interface [polypeptide binding]; other site
1127134007627	motif 1; other site
1127134007628	motif 2; other site
1127134007629	motif 3; other site
1127134007630	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
1127134007631	anticodon binding site; other site
1127134007632	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1127134007633	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134007634	FMN binding site [chemical binding]; other site
1127134007635	substrate binding site [chemical binding]; other site
1127134007636	putative catalytic residue [active]
1127134007637	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1127134007638	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1127134007639	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1127134007640	active site 2 [active]
1127134007641	active site 1 [active]
1127134007642	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134007643	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134007644	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134007645	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1127134007646	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134007647	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
1127134007648	NAD(P) binding site [chemical binding]; other site
1127134007649	catalytic residues [active]
1127134007650	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1127134007651	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1127134007652	NAD binding site [chemical binding]; other site
1127134007653	catalytic Zn binding site [ion binding]; other site
1127134007654	substrate binding site [chemical binding]; other site
1127134007655	structural Zn binding site [ion binding]; other site
1127134007656	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134007657	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134007658	substrate binding site [chemical binding]; other site
1127134007659	oxyanion hole (OAH) forming residues; other site
1127134007660	trimer interface [polypeptide binding]; other site
1127134007661	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134007662	AMP binding site [chemical binding]; other site
1127134007663	active site
1127134007664	CoA binding site [chemical binding]; other site
1127134007665	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134007666	AMP-binding enzyme; Region: AMP-binding; pfam00501
1127134007667	acyl-activating enzyme (AAE) consensus motif; other site
1127134007668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007670	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1127134007671	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1127134007672	catalytic triad [active]
1127134007673	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1127134007674	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1127134007675	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134007676	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134007677	substrate binding pocket [chemical binding]; other site
1127134007678	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134007679	Helix-turn-helix domain; Region: HTH_31; pfam13560
1127134007680	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1127134007681	classical (c) SDRs; Region: SDR_c; cd05233
1127134007682	NAD(P) binding site [chemical binding]; other site
1127134007683	active site
1127134007684	lipid-transfer protein; Provisional; Region: PRK06059
1127134007685	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
1127134007686	active site
1127134007687	DUF35 OB-fold domain; Region: DUF35; pfam01796
1127134007688	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1127134007689	Switch II region; other site
1127134007690	G4 box; other site
1127134007691	G5 box; other site
1127134007692	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
1127134007693	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1127134007694	putative active site [active]
1127134007695	putative FMN binding site [chemical binding]; other site
1127134007696	putative substrate binding site [chemical binding]; other site
1127134007697	putative catalytic residue [active]
1127134007698	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134007699	MarR family; Region: MarR; pfam01047
1127134007700	Cutinase; Region: Cutinase; pfam01083
1127134007701	AAA ATPase domain; Region: AAA_16; pfam13191
1127134007702	Predicted ATPase [General function prediction only]; Region: COG3903
1127134007703	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007704	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007705	DNA binding residues [nucleotide binding]
1127134007706	dimerization interface [polypeptide binding]; other site
1127134007707	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134007708	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
1127134007709	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134007710	Helix-turn-helix domain; Region: HTH_31; pfam13560
1127134007711	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134007712	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134007713	CAAX protease self-immunity; Region: Abi; pfam02517
1127134007714	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134007715	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134007716	DNA binding residues [nucleotide binding]
1127134007717	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134007718	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134007719	active site
1127134007720	ATP binding site [chemical binding]; other site
1127134007721	substrate binding site [chemical binding]; other site
1127134007722	activation loop (A-loop); other site
1127134007723	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134007724	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134007725	active site
1127134007726	metal binding site [ion binding]; metal-binding site
1127134007727	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1127134007728	Coenzyme A binding pocket [chemical binding]; other site
1127134007729	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134007730	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134007731	DNA binding residues [nucleotide binding]
1127134007732	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1127134007733	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
1127134007734	active site
1127134007735	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134007736	active site 2 [active]
1127134007737	active site 1 [active]
1127134007738	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134007739	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1127134007740	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1127134007741	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007742	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1127134007743	DNA-binding interface [nucleotide binding]; DNA binding site
1127134007744	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1127134007745	YCII-related domain; Region: YCII; cl00999
1127134007746	RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983
1127134007747	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134007748	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1127134007749	putative hydrophobic ligand binding site [chemical binding]; other site
1127134007750	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
1127134007751	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1127134007752	DNA-binding site [nucleotide binding]; DNA binding site
1127134007753	RNA-binding motif; other site
1127134007754	Lipase maturation factor; Region: LMF1; pfam06762
1127134007755	BNR repeat-like domain; Region: BNR_2; pfam13088
1127134007756	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
1127134007757	Asp-box motif; other site
1127134007758	Ubiquitin-like proteins; Region: UBQ; cl00155
1127134007759	charged pocket; other site
1127134007760	hydrophobic patch; other site
1127134007761	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1127134007762	GMC oxidoreductase; Region: GMC_oxred_N; pfam00732
1127134007763	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134007764	acyl-CoA synthetase; Validated; Region: PRK07788
1127134007765	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134007766	acyl-activating enzyme (AAE) consensus motif; other site
1127134007767	AMP binding site [chemical binding]; other site
1127134007768	active site
1127134007769	CoA binding site [chemical binding]; other site
1127134007770	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
1127134007771	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1127134007772	putative active site [active]
1127134007773	putative catalytic site [active]
1127134007774	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007776	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1127134007777	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134007778	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1127134007779	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1127134007780	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1127134007781	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1127134007782	molybdopterin cofactor binding site; other site
1127134007783	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1127134007784	molybdopterin cofactor binding site; other site
1127134007785	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134007786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134007787	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1127134007788	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1127134007789	active site
1127134007790	DNA binding site [nucleotide binding]
1127134007791	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1127134007792	DNA binding site [nucleotide binding]
1127134007793	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1127134007794	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134007795	active site
1127134007796	ATP binding site [chemical binding]; other site
1127134007797	substrate binding site [chemical binding]; other site
1127134007798	activation loop (A-loop); other site
1127134007799	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
1127134007800	P-loop motif; other site
1127134007801	ATP binding site [chemical binding]; other site
1127134007802	Chloramphenicol (Cm) binding site [chemical binding]; other site
1127134007803	catalytic residue [active]
1127134007804	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134007805	DNA binding residues [nucleotide binding]
1127134007806	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134007807	Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773
1127134007808	DNA binding residues [nucleotide binding]
1127134007809	putative dimer interface [polypeptide binding]; other site
1127134007810	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1127134007811	oxidoreductase; Provisional; Region: PRK12743
1127134007812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007813	NAD(P) binding site [chemical binding]; other site
1127134007814	active site
1127134007815	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1127134007816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007817	NAD(P) binding site [chemical binding]; other site
1127134007818	active site
1127134007819	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1127134007820	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1127134007821	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1127134007822	ATP binding site [chemical binding]; other site
1127134007823	substrate binding site [chemical binding]; other site
1127134007824	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1127134007825	dimer interface [polypeptide binding]; other site
1127134007826	active site
1127134007827	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134007828	active site
1127134007829	motif I; other site
1127134007830	motif II; other site
1127134007831	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1127134007832	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1127134007833	putative active site [active]
1127134007834	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1127134007835	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134007836	classical (c) SDRs; Region: SDR_c; cd05233
1127134007837	NAD(P) binding site [chemical binding]; other site
1127134007838	active site
1127134007839	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134007840	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1127134007841	putative ADP-binding pocket [chemical binding]; other site
1127134007842	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1127134007843	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1127134007844	putative active site [active]
1127134007845	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1127134007846	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1127134007847	active site
1127134007848	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
1127134007849	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1127134007850	substrate binding site [chemical binding]; other site
1127134007851	ATP binding site [chemical binding]; other site
1127134007852	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
1127134007853	active site
1127134007854	nucleotide binding site [chemical binding]; other site
1127134007855	HIGH motif; other site
1127134007856	KMSKS motif; other site
1127134007857	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1127134007858	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1127134007859	D-pathway; other site
1127134007860	Putative ubiquinol binding site [chemical binding]; other site
1127134007861	Low-spin heme (heme b) binding site [chemical binding]; other site
1127134007862	Putative water exit pathway; other site
1127134007863	Binuclear center (heme o3/CuB) [ion binding]; other site
1127134007864	K-pathway; other site
1127134007865	Putative proton exit pathway; other site
1127134007866	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1127134007867	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
1127134007868	active site
1127134007869	DNA binding site [nucleotide binding]
1127134007870	Int/Topo IB signature motif; other site
1127134007871	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134007872	hydrophobic ligand binding site; other site
1127134007873	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1127134007874	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1127134007875	NAD binding site [chemical binding]; other site
1127134007876	catalytic Zn binding site [ion binding]; other site
1127134007877	structural Zn binding site [ion binding]; other site
1127134007878	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1127134007879	hydrophobic ligand binding site; other site
1127134007880	thiamine pyrophosphate protein; Provisional; Region: PRK08273
1127134007881	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1127134007882	PYR/PP interface [polypeptide binding]; other site
1127134007883	tetramer interface [polypeptide binding]; other site
1127134007884	dimer interface [polypeptide binding]; other site
1127134007885	TPP binding site [chemical binding]; other site
1127134007886	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1127134007887	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1127134007888	TPP-binding site [chemical binding]; other site
1127134007889	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1127134007890	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1127134007891	dimerization interface [polypeptide binding]; other site
1127134007892	DPS ferroxidase diiron center [ion binding]; other site
1127134007893	ion pore; other site
1127134007894	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134007895	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1127134007896	Low affinity iron permease; Region: Iron_permease; cl12096
1127134007897	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134007898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007899	NAD(P) binding site [chemical binding]; other site
1127134007900	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1127134007901	active site
1127134007902	BCCT family transporter; Region: BCCT; cl00569
1127134007903	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134007904	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134007905	NAD(P) binding site [chemical binding]; other site
1127134007906	catalytic residues [active]
1127134007907	choline dehydrogenase; Validated; Region: PRK02106
1127134007908	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134007909	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1127134007910	RDD family; Region: RDD; pfam06271
1127134007911	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1127134007912	active site
1127134007913	SnoaL-like domain; Region: SnoaL_4; pfam13577
1127134007914	SnoaL-like domain; Region: SnoaL_4; pfam13577
1127134007915	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134007916	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134007917	active site
1127134007918	ATP binding site [chemical binding]; other site
1127134007919	substrate binding site [chemical binding]; other site
1127134007920	activation loop (A-loop); other site
1127134007921	AAA ATPase domain; Region: AAA_16; pfam13191
1127134007922	AAA domain; Region: AAA_22; pfam13401
1127134007923	Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077
1127134007924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134007925	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134007926	putative substrate translocation pore; other site
1127134007927	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134007928	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134007929	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436
1127134007930	putative dimerization interface [polypeptide binding]; other site
1127134007931	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1127134007932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007933	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134007934	NAD(P) binding site [chemical binding]; other site
1127134007935	active site
1127134007936	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134007937	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1127134007938	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134007939	S-adenosylmethionine binding site [chemical binding]; other site
1127134007940	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134007941	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
1127134007942	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134007943	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007944	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007945	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
1127134007946	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134007947	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134007948	catalytic residue [active]
1127134007949	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1127134007950	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1127134007951	active site
1127134007952	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1127134007953	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1127134007954	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134007955	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
1127134007956	Enoylreductase; Region: PKS_ER; smart00829
1127134007957	NAD(P) binding site [chemical binding]; other site
1127134007958	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1127134007959	KR domain; Region: KR; pfam08659
1127134007960	putative NADP binding site [chemical binding]; other site
1127134007961	active site
1127134007962	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134007963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134007964	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1127134007965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134007966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134007967	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1127134007968	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1127134007969	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134007970	active site
1127134007971	metal binding site [ion binding]; metal-binding site
1127134007972	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134007973	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134007974	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134007975	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134007976	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134007977	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134007978	putative metal binding site [ion binding]; other site
1127134007979	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134007980	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1127134007981	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1127134007982	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1127134007983	active site
1127134007984	trimer interface [polypeptide binding]; other site
1127134007985	allosteric site; other site
1127134007986	active site lid [active]
1127134007987	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1127134007988	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1127134007989	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134007990	active site
1127134007991	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1127134007992	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1127134007993	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164
1127134007994	active site turn [active]
1127134007995	phosphorylation site [posttranslational modification]
1127134007996	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1127134007997	HPr interaction site; other site
1127134007998	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1127134007999	active site
1127134008000	phosphorylation site [posttranslational modification]
1127134008001	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1127134008002	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134008003	DNA-binding site [nucleotide binding]; DNA binding site
1127134008004	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1127134008005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134008006	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1127134008007	putative substrate translocation pore; other site
1127134008008	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1127134008009	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008010	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134008011	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134008012	non-specific DNA binding site [nucleotide binding]; other site
1127134008013	salt bridge; other site
1127134008014	sequence-specific DNA binding site [nucleotide binding]; other site
1127134008015	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
1127134008016	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
1127134008017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1127134008018	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134008019	putative metal binding site [ion binding]; other site
1127134008020	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134008021	dimerization interface [polypeptide binding]; other site
1127134008022	putative DNA binding site [nucleotide binding]; other site
1127134008023	putative Zn2+ binding site [ion binding]; other site
1127134008024	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1127134008025	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134008026	BCCT family transporter; Region: BCCT; pfam02028
1127134008027	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1127134008028	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1127134008029	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1127134008030	Fructosamine kinase; Region: Fructosamin_kin; cl17579
1127134008031	PhoD-like phosphatase; Region: PhoD; pfam09423
1127134008032	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1127134008033	putative active site [active]
1127134008034	putative metal binding site [ion binding]; other site
1127134008035	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1127134008036	Predicted membrane protein [Function unknown]; Region: COG4425
1127134008037	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1127134008038	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134008039	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1127134008040	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1127134008041	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1127134008042	Protein kinase domain; Region: Pkinase; pfam00069
1127134008043	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134008044	active site
1127134008045	ATP binding site [chemical binding]; other site
1127134008046	substrate binding site [chemical binding]; other site
1127134008047	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134008048	substrate binding site [chemical binding]; other site
1127134008049	activation loop (A-loop); other site
1127134008050	activation loop (A-loop); other site
1127134008051	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1127134008052	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1127134008053	binding surface
1127134008054	TPR motif; other site
1127134008055	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
1127134008056	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134008057	S-adenosylmethionine binding site [chemical binding]; other site
1127134008058	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1127134008059	L-ectoine synthase; Reviewed; Region: ectC; PRK13290
1127134008060	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1127134008061	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134008062	inhibitor-cofactor binding pocket; inhibition site
1127134008063	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134008064	catalytic residue [active]
1127134008065	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134008066	Coenzyme A binding pocket [chemical binding]; other site
1127134008067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134008068	ATP binding site [chemical binding]; other site
1127134008069	Mg2+ binding site [ion binding]; other site
1127134008070	G-X-G motif; other site
1127134008071	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134008072	dimerization interface [polypeptide binding]; other site
1127134008073	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134008074	dimer interface [polypeptide binding]; other site
1127134008075	phosphorylation site [posttranslational modification]
1127134008076	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134008077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134008078	active site
1127134008079	phosphorylation site [posttranslational modification]
1127134008080	intermolecular recognition site; other site
1127134008081	dimerization interface [polypeptide binding]; other site
1127134008082	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134008083	DNA binding site [nucleotide binding]
1127134008084	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1127134008085	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1127134008086	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134008087	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1127134008088	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134008089	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134008090	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008091	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1127134008092	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1127134008093	active site
1127134008094	dimer interface [polypeptide binding]; other site
1127134008095	non-prolyl cis peptide bond; other site
1127134008096	insertion regions; other site
1127134008097	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134008098	active site
1127134008099	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1127134008100	nudix motif; other site
1127134008101	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1127134008102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134008103	S-adenosylmethionine binding site [chemical binding]; other site
1127134008104	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
1127134008105	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134008106	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1127134008107	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
1127134008108	NADP binding site [chemical binding]; other site
1127134008109	putative substrate binding site [chemical binding]; other site
1127134008110	active site
1127134008111	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008112	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008113	WHG domain; Region: WHG; pfam13305
1127134008114	Uncharacterized conserved protein [Function unknown]; Region: COG3379
1127134008115	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1127134008116	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1127134008117	DNA binding site [nucleotide binding]
1127134008118	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008119	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1127134008120	Walker A/P-loop; other site
1127134008121	ATP binding site [chemical binding]; other site
1127134008122	Q-loop/lid; other site
1127134008123	ABC transporter signature motif; other site
1127134008124	Walker B; other site
1127134008125	D-loop; other site
1127134008126	H-loop/switch region; other site
1127134008127	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134008128	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134008129	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008130	Walker A/P-loop; other site
1127134008131	ATP binding site [chemical binding]; other site
1127134008132	Q-loop/lid; other site
1127134008133	ABC transporter signature motif; other site
1127134008134	Walker B; other site
1127134008135	D-loop; other site
1127134008136	H-loop/switch region; other site
1127134008137	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008138	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1127134008139	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134008140	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1127134008141	dimerization interface [polypeptide binding]; other site
1127134008142	Protein of unknown function (DUF779); Region: DUF779; cl01432
1127134008143	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134008144	putative DNA binding site [nucleotide binding]; other site
1127134008145	putative Zn2+ binding site [ion binding]; other site
1127134008146	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134008147	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134008148	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1127134008149	succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407
1127134008150	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101
1127134008151	NAD(P) binding site [chemical binding]; other site
1127134008152	catalytic residues [active]
1127134008153	Nitrate and nitrite sensing; Region: NIT; pfam08376
1127134008154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134008155	ATP binding site [chemical binding]; other site
1127134008156	Mg2+ binding site [ion binding]; other site
1127134008157	G-X-G motif; other site
1127134008158	Roadblock/LC7 domain; Region: Robl_LC7; pfam03259
1127134008159	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1127134008160	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1127134008161	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1127134008162	G1 box; other site
1127134008163	GTP/Mg2+ binding site [chemical binding]; other site
1127134008164	G2 box; other site
1127134008165	Switch I region; other site
1127134008166	G3 box; other site
1127134008167	Switch II region; other site
1127134008168	G4 box; other site
1127134008169	G5 box; other site
1127134008170	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1127134008171	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1127134008172	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1127134008173	nudix motif; other site
1127134008174	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1127134008175	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134008176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008177	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134008178	Walker A/P-loop; other site
1127134008179	ATP binding site [chemical binding]; other site
1127134008180	Q-loop/lid; other site
1127134008181	ABC transporter signature motif; other site
1127134008182	Walker B; other site
1127134008183	D-loop; other site
1127134008184	H-loop/switch region; other site
1127134008185	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008186	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008187	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134008188	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1127134008189	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1127134008190	DNA polymerase IV; Validated; Region: PRK03858
1127134008191	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1127134008192	active site
1127134008193	DNA binding site [nucleotide binding]
1127134008194	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1127134008195	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1127134008196	phosphoribulokinase; Provisional; Region: PRK15453
1127134008197	active site
1127134008198	fructose-1,6-bisphosphatase family protein; Region: PLN02628
1127134008199	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1127134008200	AMP binding site [chemical binding]; other site
1127134008201	metal binding site [ion binding]; metal-binding site
1127134008202	active site
1127134008203	probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880
1127134008204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134008205	Walker A motif; other site
1127134008206	ATP binding site [chemical binding]; other site
1127134008207	Walker B motif; other site
1127134008208	arginine finger; other site
1127134008209	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
1127134008210	multimerization interface [polypeptide binding]; other site
1127134008211	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
1127134008212	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
1127134008213	homodimer interface [polypeptide binding]; other site
1127134008214	active site
1127134008215	heterodimer interface [polypeptide binding]; other site
1127134008216	catalytic residue [active]
1127134008217	metal binding site [ion binding]; metal-binding site
1127134008218	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134008219	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134008220	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134008221	dimerization interface [polypeptide binding]; other site
1127134008222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1127134008223	active site
1127134008224	phosphorylation site [posttranslational modification]
1127134008225	intermolecular recognition site; other site
1127134008226	dimerization interface [polypeptide binding]; other site
1127134008227	NADH dehydrogenase subunit A; Validated; Region: PRK07928
1127134008228	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1127134008229	NADH dehydrogenase subunit C; Provisional; Region: PRK07785
1127134008230	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1127134008231	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1127134008232	NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962
1127134008233	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1127134008234	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1127134008235	putative dimer interface [polypeptide binding]; other site
1127134008236	[2Fe-2S] cluster binding site [ion binding]; other site
1127134008237	NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959
1127134008238	SLBB domain; Region: SLBB; pfam10531
1127134008239	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
1127134008240	NADH dehydrogenase subunit G; Validated; Region: PRK07860
1127134008241	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134008242	catalytic loop [active]
1127134008243	iron binding site [ion binding]; other site
1127134008244	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1127134008245	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134008246	molybdopterin cofactor binding site; other site
1127134008247	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
1127134008248	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1127134008249	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1127134008250	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1127134008251	4Fe-4S binding domain; Region: Fer4; pfam00037
1127134008252	4Fe-4S binding domain; Region: Fer4; pfam00037
1127134008253	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1127134008254	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1127134008255	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1127134008256	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
1127134008257	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1127134008258	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1127134008259	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1127134008260	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1127134008261	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1127134008262	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1127134008263	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1127134008264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008265	Walker A/P-loop; other site
1127134008266	ATP binding site [chemical binding]; other site
1127134008267	Q-loop/lid; other site
1127134008268	ABC transporter signature motif; other site
1127134008269	Walker B; other site
1127134008270	D-loop; other site
1127134008271	H-loop/switch region; other site
1127134008272	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008273	Walker A/P-loop; other site
1127134008274	ATP binding site [chemical binding]; other site
1127134008275	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008276	ABC transporter signature motif; other site
1127134008277	Walker B; other site
1127134008278	D-loop; other site
1127134008279	H-loop/switch region; other site
1127134008280	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1127134008281	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
1127134008282	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134008283	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134008284	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134008285	dimerization interface [polypeptide binding]; other site
1127134008286	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1127134008287	classical (c) SDRs; Region: SDR_c; cd05233
1127134008288	NAD(P) binding site [chemical binding]; other site
1127134008289	active site
1127134008290	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
1127134008291	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134008292	dimerization interface [polypeptide binding]; other site
1127134008293	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134008294	dimer interface [polypeptide binding]; other site
1127134008295	phosphorylation site [posttranslational modification]
1127134008296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134008297	ATP binding site [chemical binding]; other site
1127134008298	Mg2+ binding site [ion binding]; other site
1127134008299	G-X-G motif; other site
1127134008300	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134008301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134008302	active site
1127134008303	phosphorylation site [posttranslational modification]
1127134008304	intermolecular recognition site; other site
1127134008305	dimerization interface [polypeptide binding]; other site
1127134008306	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134008307	DNA binding site [nucleotide binding]
1127134008308	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1127134008309	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
1127134008310	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134008311	S-adenosylmethionine binding site [chemical binding]; other site
1127134008312	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
1127134008313	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1127134008314	putative active site [active]
1127134008315	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1127134008316	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134008317	dimerization interface [polypeptide binding]; other site
1127134008318	putative DNA binding site [nucleotide binding]; other site
1127134008319	putative Zn2+ binding site [ion binding]; other site
1127134008320	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1127134008321	Peptidase family M23; Region: Peptidase_M23; pfam01551
1127134008322	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
1127134008323	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
1127134008324	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1127134008325	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1127134008326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008327	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134008328	Walker A/P-loop; other site
1127134008329	ATP binding site [chemical binding]; other site
1127134008330	Q-loop/lid; other site
1127134008331	ABC transporter signature motif; other site
1127134008332	Walker B; other site
1127134008333	D-loop; other site
1127134008334	H-loop/switch region; other site
1127134008335	Condensation domain; Region: Condensation; pfam00668
1127134008336	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134008337	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134008338	acyl-activating enzyme (AAE) consensus motif; other site
1127134008339	AMP binding site [chemical binding]; other site
1127134008340	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134008341	Condensation domain; Region: Condensation; pfam00668
1127134008342	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134008343	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134008344	The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); Region: A_NRPS_SidN3_like; cd05918
1127134008345	acyl-activating enzyme (AAE) consensus motif; other site
1127134008346	AMP binding site [chemical binding]; other site
1127134008347	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134008348	Condensation domain; Region: Condensation; pfam00668
1127134008349	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134008350	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134008351	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134008352	acyl-activating enzyme (AAE) consensus motif; other site
1127134008353	AMP binding site [chemical binding]; other site
1127134008354	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134008355	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1127134008356	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134008357	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134008358	acyl-activating enzyme (AAE) consensus motif; other site
1127134008359	AMP binding site [chemical binding]; other site
1127134008360	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134008361	Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815
1127134008362	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1127134008363	putative active site [active]
1127134008364	catalytic triad [active]
1127134008365	putative dimer interface [polypeptide binding]; other site
1127134008366	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1127134008367	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134008368	active site
1127134008369	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
1127134008370	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134008371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134008372	active site
1127134008373	phosphorylation site [posttranslational modification]
1127134008374	intermolecular recognition site; other site
1127134008375	dimerization interface [polypeptide binding]; other site
1127134008376	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134008377	DNA binding residues [nucleotide binding]
1127134008378	dimerization interface [polypeptide binding]; other site
1127134008379	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134008380	Histidine kinase; Region: HisKA_3; pfam07730
1127134008381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134008382	ATP binding site [chemical binding]; other site
1127134008383	Mg2+ binding site [ion binding]; other site
1127134008384	G-X-G motif; other site
1127134008385	hypothetical protein; Provisional; Region: PRK10621
1127134008386	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1127134008387	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008388	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1127134008389	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1127134008390	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1127134008391	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1127134008392	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1127134008393	NAD binding site [chemical binding]; other site
1127134008394	substrate binding site [chemical binding]; other site
1127134008395	homodimer interface [polypeptide binding]; other site
1127134008396	active site
1127134008397	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
1127134008398	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134008399	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134008400	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134008401	active site
1127134008402	metal binding site [ion binding]; metal-binding site
1127134008403	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134008404	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1127134008405	active site
1127134008406	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134008407	sequence-specific DNA binding site [nucleotide binding]; other site
1127134008408	salt bridge; other site
1127134008409	PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666
1127134008410	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1127134008411	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1127134008412	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1127134008413	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1127134008414	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1127134008415	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1127134008416	NAD(P) binding site [chemical binding]; other site
1127134008417	substrate binding site [chemical binding]; other site
1127134008418	dimer interface [polypeptide binding]; other site
1127134008419	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
1127134008420	GXWXG protein; Region: GXWXG; pfam14231
1127134008421	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
1127134008422	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1127134008423	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
1127134008424	catalytic Zn binding site [ion binding]; other site
1127134008425	NAD binding site [chemical binding]; other site
1127134008426	structural Zn binding site [ion binding]; other site
1127134008427	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134008428	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134008429	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134008430	dimerization interface [polypeptide binding]; other site
1127134008431	putative DNA binding site [nucleotide binding]; other site
1127134008432	putative Zn2+ binding site [ion binding]; other site
1127134008433	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134008434	hydrophobic ligand binding site; other site
1127134008435	precorrin-3B synthase; Region: CobG; TIGR02435
1127134008436	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1127134008437	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1127134008438	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1127134008439	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1127134008440	active site
1127134008441	SAM binding site [chemical binding]; other site
1127134008442	homodimer interface [polypeptide binding]; other site
1127134008443	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1127134008444	active site
1127134008445	SAM binding site [chemical binding]; other site
1127134008446	homodimer interface [polypeptide binding]; other site
1127134008447	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134008448	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134008449	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1127134008450	RibD C-terminal domain; Region: RibD_C; cl17279
1127134008451	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1127134008452	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1127134008453	active site
1127134008454	putative homodimer interface [polypeptide binding]; other site
1127134008455	SAM binding site [chemical binding]; other site
1127134008456	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1127134008457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134008458	S-adenosylmethionine binding site [chemical binding]; other site
1127134008459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134008460	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1127134008461	NAD(P) binding site [chemical binding]; other site
1127134008462	active site
1127134008463	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1127134008464	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1127134008465	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1127134008466	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1127134008467	active site
1127134008468	5'-3' exonuclease, N-terminal resolvase-like domain; Region: 5_3_exonuc_N; pfam02739
1127134008469	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1127134008470	active site
1127134008471	metal binding site 1 [ion binding]; metal-binding site
1127134008472	putative 5' ssDNA interaction site; other site
1127134008473	metal binding site 3; metal-binding site
1127134008474	metal binding site 2 [ion binding]; metal-binding site
1127134008475	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1127134008476	putative DNA binding site [nucleotide binding]; other site
1127134008477	putative metal binding site [ion binding]; other site
1127134008478	Domain of unknown function (DUF4333); Region: DUF4333; pfam14230
1127134008479	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1127134008480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134008481	ATP binding site [chemical binding]; other site
1127134008482	putative Mg++ binding site [ion binding]; other site
1127134008483	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134008484	ATP-binding site [chemical binding]; other site
1127134008485	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1127134008486	Twin arginine targeting (Tat) protein translocase TatC; Region: tatC; TIGR00945
1127134008487	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1127134008488	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
1127134008489	2-dehydropantoate 2-reductase; Provisional; Region: PRK08229
1127134008490	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1127134008491	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1127134008492	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134008493	WYL domain; Region: WYL; pfam13280
1127134008494	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134008495	WYL domain; Region: WYL; pfam13280
1127134008496	Domain of unknown function DUF77; Region: DUF77; pfam01910
1127134008497	proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686
1127134008498	proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691
1127134008499	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1127134008500	active site
1127134008501	proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690
1127134008502	proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906
1127134008503	active site
1127134008504	Pup-like protein; Region: Pup; cl05289
1127134008505	proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688
1127134008506	Predicted membrane protein [Function unknown]; Region: COG2311
1127134008507	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1127134008508	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
1127134008509	CGNR zinc finger; Region: zf-CGNR; pfam11706
1127134008510	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1127134008511	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1127134008512	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1127134008513	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1127134008514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008515	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134008516	CoenzymeA binding site [chemical binding]; other site
1127134008517	subunit interaction site [polypeptide binding]; other site
1127134008518	PHB binding site; other site
1127134008519	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1127134008520	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1127134008521	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134008522	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1127134008523	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1127134008524	nudix motif; other site
1127134008525	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1127134008526	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1127134008527	ArsC family; Region: ArsC; pfam03960
1127134008528	catalytic residues [active]
1127134008529	proteasome ATPase; Region: pup_AAA; TIGR03689
1127134008530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134008531	Walker A motif; other site
1127134008532	ATP binding site [chemical binding]; other site
1127134008533	Walker B motif; other site
1127134008534	arginine finger; other site
1127134008535	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
1127134008536	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134008537	S-adenosylmethionine binding site [chemical binding]; other site
1127134008538	RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887
1127134008539	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1127134008540	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
1127134008541	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
1127134008542	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
1127134008543	homodimer interface [polypeptide binding]; other site
1127134008544	putative metal binding site [ion binding]; other site
1127134008545	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
1127134008546	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1127134008547	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
1127134008548	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134008549	motif II; other site
1127134008550	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1127134008551	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134008552	active site
1127134008553	ATP binding site [chemical binding]; other site
1127134008554	substrate binding site [chemical binding]; other site
1127134008555	activation loop (A-loop); other site
1127134008556	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1127134008557	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1127134008558	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1127134008559	substrate binding pocket [chemical binding]; other site
1127134008560	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1127134008561	B12 binding site [chemical binding]; other site
1127134008562	cobalt ligand [ion binding]; other site
1127134008563	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1127134008564	PAC2 family; Region: PAC2; pfam09754
1127134008565	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
1127134008566	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
1127134008567	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
1127134008568	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134008569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134008570	non-specific DNA binding site [nucleotide binding]; other site
1127134008571	salt bridge; other site
1127134008572	sequence-specific DNA binding site [nucleotide binding]; other site
1127134008573	Flavoprotein; Region: Flavoprotein; cl08021
1127134008574	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1127134008575	Zn2+ binding site [ion binding]; other site
1127134008576	Mg2+ binding site [ion binding]; other site
1127134008577	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1127134008578	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134008579	sequence-specific DNA binding site [nucleotide binding]; other site
1127134008580	salt bridge; other site
1127134008581	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1127134008582	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1127134008583	fumarate hydratase; Provisional; Region: PRK15389
1127134008584	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1127134008585	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1127134008586	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1127134008587	MarR family; Region: MarR_2; pfam12802
1127134008588	heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966
1127134008589	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1127134008590	phosphate binding site [ion binding]; other site
1127134008591	mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964
1127134008592	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1127134008593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008594	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1127134008595	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1127134008596	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1127134008597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1127134008598	ATP binding site [chemical binding]; other site
1127134008599	Mg2+ binding site [ion binding]; other site
1127134008600	G-X-G motif; other site
1127134008601	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1127134008602	PAS domain S-box; Region: sensory_box; TIGR00229
1127134008603	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1127134008604	putative active site [active]
1127134008605	heme pocket [chemical binding]; other site
1127134008606	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1127134008607	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1127134008608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134008609	ATP binding site [chemical binding]; other site
1127134008610	Mg2+ binding site [ion binding]; other site
1127134008611	G-X-G motif; other site
1127134008612	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1127134008613	anti sigma factor interaction site; other site
1127134008614	regulatory phosphorylation site [posttranslational modification]; other site
1127134008615	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1127134008616	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1127134008617	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
1127134008618	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1127134008619	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134008620	putative ADP-binding pocket [chemical binding]; other site
1127134008621	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1127134008622	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1127134008623	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1127134008624	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1127134008625	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1127134008626	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134008627	Ligand Binding Site [chemical binding]; other site
1127134008628	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008629	Walker A/P-loop; other site
1127134008630	ATP binding site [chemical binding]; other site
1127134008631	Q-loop/lid; other site
1127134008632	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
1127134008633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008634	ABC transporter signature motif; other site
1127134008635	Walker B; other site
1127134008636	D-loop; other site
1127134008637	H-loop/switch region; other site
1127134008638	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008639	Walker A/P-loop; other site
1127134008640	ATP binding site [chemical binding]; other site
1127134008641	Q-loop/lid; other site
1127134008642	ABC transporter signature motif; other site
1127134008643	Walker B; other site
1127134008644	D-loop; other site
1127134008645	H-loop/switch region; other site
1127134008646	HTH domain; Region: HTH_11; pfam08279
1127134008647	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134008648	WYL domain; Region: WYL; pfam13280
1127134008649	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
1127134008650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134008652	Walker B; other site
1127134008653	D-loop; other site
1127134008654	H-loop/switch region; other site
1127134008655	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1127134008656	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1127134008657	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134008658	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134008659	Cytochrome P450; Region: p450; cl12078
1127134008660	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134008661	Cytochrome P450; Region: p450; cl12078
1127134008662	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134008663	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1127134008664	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1127134008665	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
1127134008666	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134008667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134008668	ATP binding site [chemical binding]; other site
1127134008669	Mg2+ binding site [ion binding]; other site
1127134008670	G-X-G motif; other site
1127134008671	CHAT domain; Region: CHAT; cl17868
1127134008672	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134008673	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1127134008674	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1127134008675	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1127134008676	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1127134008677	trimerization site [polypeptide binding]; other site
1127134008678	active site
1127134008679	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1127134008680	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1127134008681	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134008682	catalytic residue [active]
1127134008683	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1127134008684	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1127134008685	Walker A/P-loop; other site
1127134008686	ATP binding site [chemical binding]; other site
1127134008687	Q-loop/lid; other site
1127134008688	ABC transporter signature motif; other site
1127134008689	Walker B; other site
1127134008690	D-loop; other site
1127134008691	H-loop/switch region; other site
1127134008692	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1127134008693	FeS assembly protein SufD; Region: sufD; TIGR01981
1127134008694	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1127134008695	FeS assembly protein SufB; Region: sufB; TIGR01980
1127134008696	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134008697	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
1127134008698	putative Zn2+ binding site [ion binding]; other site
1127134008699	putative DNA binding site [nucleotide binding]; other site
1127134008700	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
1127134008701	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134008702	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134008703	Walker A/P-loop; other site
1127134008704	ATP binding site [chemical binding]; other site
1127134008705	Q-loop/lid; other site
1127134008706	ABC transporter signature motif; other site
1127134008707	Walker B; other site
1127134008708	D-loop; other site
1127134008709	H-loop/switch region; other site
1127134008710	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134008711	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134008712	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1127134008713	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1127134008714	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1127134008715	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134008716	MarR family; Region: MarR; pfam01047
1127134008717	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134008718	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
1127134008719	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
1127134008720	NADP binding site [chemical binding]; other site
1127134008721	dimer interface [polypeptide binding]; other site
1127134008722	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008723	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008724	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134008725	hypothetical protein; Provisional; Region: PRK06184
1127134008726	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134008727	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134008728	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1127134008729	UbiA prenyltransferase family; Region: UbiA; pfam01040
1127134008730	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1127134008731	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1127134008732	TPP-binding site [chemical binding]; other site
1127134008733	dimer interface [polypeptide binding]; other site
1127134008734	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1127134008735	PYR/PP interface [polypeptide binding]; other site
1127134008736	dimer interface [polypeptide binding]; other site
1127134008737	TPP binding site [chemical binding]; other site
1127134008738	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1127134008739	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1127134008740	putative active site [active]
1127134008741	transaldolase; Provisional; Region: PRK03903
1127134008742	catalytic residue [active]
1127134008743	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1127134008744	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1127134008745	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1127134008746	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1127134008747	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
1127134008748	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1127134008749	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1127134008750	putative active site [active]
1127134008751	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
1127134008752	putative deacylase active site [active]
1127134008753	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1127134008754	TPP-binding site [chemical binding]; other site
1127134008755	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1127134008756	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1127134008757	PYR/PP interface [polypeptide binding]; other site
1127134008758	dimer interface [polypeptide binding]; other site
1127134008759	TPP binding site [chemical binding]; other site
1127134008760	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1127134008761	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134008762	hydrophobic ligand binding site; other site
1127134008763	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1127134008764	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1127134008765	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134008766	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134008767	DNA binding residues [nucleotide binding]
1127134008768	dimerization interface [polypeptide binding]; other site
1127134008769	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1127134008770	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
1127134008771	substrate binding site [chemical binding]; other site
1127134008772	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134008773	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
1127134008774	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134008775	EspG family; Region: ESX-1_EspG; pfam14011
1127134008776	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1127134008777	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1127134008778	Moco binding site; other site
1127134008779	metal coordination site [ion binding]; other site
1127134008780	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008781	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008782	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134008783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134008784	S-adenosylmethionine binding site [chemical binding]; other site
1127134008785	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134008786	short chain dehydrogenase; Provisional; Region: PRK08303
1127134008787	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134008788	NAD(P) binding site [chemical binding]; other site
1127134008789	active site
1127134008790	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134008791	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134008792	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134008793	Transmembrane secretion effector; Region: MFS_3; pfam05977
1127134008794	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134008795	putative substrate translocation pore; other site
1127134008796	Domain of unknown function (DUF3841); Region: DUF3841; pfam12952
1127134008797	META domain; Region: META; pfam03724
1127134008798	META domain; Region: META; pfam03724
1127134008799	triosephosphate isomerase; Provisional; Region: PRK14567
1127134008800	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1127134008801	substrate binding site [chemical binding]; other site
1127134008802	dimer interface [polypeptide binding]; other site
1127134008803	catalytic triad [active]
1127134008804	Phosphoglycerate kinase; Region: PGK; pfam00162
1127134008805	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1127134008806	substrate binding site [chemical binding]; other site
1127134008807	hinge regions; other site
1127134008808	ADP binding site [chemical binding]; other site
1127134008809	catalytic site [active]
1127134008810	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1127134008811	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1127134008812	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1127134008813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1127134008814	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1127134008815	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1127134008816	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1127134008817	phosphate binding site [ion binding]; other site
1127134008818	putative substrate binding pocket [chemical binding]; other site
1127134008819	dimer interface [polypeptide binding]; other site
1127134008820	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1127134008821	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1127134008822	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1127134008823	GIY-YIG motif/motif A; other site
1127134008824	active site
1127134008825	catalytic site [active]
1127134008826	putative DNA binding site [nucleotide binding]; other site
1127134008827	metal binding site [ion binding]; metal-binding site
1127134008828	UvrB/uvrC motif; Region: UVR; pfam02151
1127134008829	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1127134008830	minor groove reading motif; other site
1127134008831	Helix-hairpin-helix motif; Region: HHH; pfam00633
1127134008832	helix-hairpin-helix signature motif; other site
1127134008833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134008834	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1127134008835	NAD(P) binding site [chemical binding]; other site
1127134008836	active site
1127134008837	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1127134008838	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1127134008839	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1127134008840	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1127134008841	homopentamer interface [polypeptide binding]; other site
1127134008842	active site
1127134008843	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1127134008844	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1127134008845	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1127134008846	dimerization interface [polypeptide binding]; other site
1127134008847	active site
1127134008848	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1127134008849	Lumazine binding domain; Region: Lum_binding; pfam00677
1127134008850	Lumazine binding domain; Region: Lum_binding; pfam00677
1127134008851	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1127134008852	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1127134008853	substrate binding site [chemical binding]; other site
1127134008854	hexamer interface [polypeptide binding]; other site
1127134008855	metal binding site [ion binding]; metal-binding site
1127134008856	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1127134008857	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1127134008858	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134008859	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1127134008860	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134008861	DNA binding residues [nucleotide binding]
1127134008862	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1127134008863	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1127134008864	putative RNA binding site [nucleotide binding]; other site
1127134008865	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1127134008866	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1127134008867	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1127134008868	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1127134008869	putative active site [active]
1127134008870	substrate binding site [chemical binding]; other site
1127134008871	putative cosubstrate binding site; other site
1127134008872	catalytic site [active]
1127134008873	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1127134008874	substrate binding site [chemical binding]; other site
1127134008875	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1127134008876	active site
1127134008877	catalytic residues [active]
1127134008878	metal binding site [ion binding]; metal-binding site
1127134008879	Lipase (class 2); Region: Lipase_2; pfam01674
1127134008880	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134008881	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134008882	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1127134008883	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008884	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008885	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1127134008886	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134008887	NAD(P) binding site [chemical binding]; other site
1127134008888	active site
1127134008889	primosome assembly protein PriA; Provisional; Region: PRK14873
1127134008890	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1127134008891	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1127134008892	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1127134008893	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1127134008894	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1127134008895	Flavoprotein; Region: Flavoprotein; pfam02441
1127134008896	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1127134008897	DNA-directed RNA polymerase, subunit K/omega [Transcription]; Region: RpoZ; COG1758
1127134008898	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1127134008899	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1127134008900	catalytic site [active]
1127134008901	G-X2-G-X-G-K; other site
1127134008902	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1127134008903	active site
1127134008904	dimer interface [polypeptide binding]; other site
1127134008905	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1127134008906	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134008907	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134008908	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1127134008909	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134008910	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134008911	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1127134008912	IMP binding site; other site
1127134008913	dimer interface [polypeptide binding]; other site
1127134008914	interdomain contacts; other site
1127134008915	partial ornithine binding site; other site
1127134008916	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1127134008917	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1127134008918	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1127134008919	catalytic site [active]
1127134008920	subunit interface [polypeptide binding]; other site
1127134008921	dihydroorotase; Validated; Region: pyrC; PRK09357
1127134008922	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134008923	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1127134008924	active site
1127134008925	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1127134008926	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1127134008927	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1127134008928	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1127134008929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134008930	active site
1127134008931	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1127134008932	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1127134008933	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
1127134008934	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
1127134008935	HD domain; Region: HD_4; pfam13328
1127134008936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134008937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008938	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134008939	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1127134008940	NAD(P) binding site [chemical binding]; other site
1127134008941	GXWXG protein; Region: GXWXG; pfam14231
1127134008942	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
1127134008943	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
1127134008944	SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137
1127134008945	reactive center loop; other site
1127134008946	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1127134008947	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134008948	DNA binding residues [nucleotide binding]
1127134008949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134008950	YCII-related domain; Region: YCII; cl00999
1127134008951	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1127134008952	putative RNA binding site [nucleotide binding]; other site
1127134008953	elongation factor P; Validated; Region: PRK00529
1127134008954	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1127134008955	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1127134008956	RNA binding site [nucleotide binding]; other site
1127134008957	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1127134008958	RNA binding site [nucleotide binding]; other site
1127134008959	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1127134008960	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1127134008961	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1127134008962	active site
1127134008963	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1127134008964	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1127134008965	mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968
1127134008966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134008967	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1127134008968	chorismate synthase; Validated; Region: PRK05382
1127134008969	Tetramer interface [polypeptide binding]; other site
1127134008970	active site
1127134008971	FMN-binding site [chemical binding]; other site
1127134008972	shikimate kinase; Reviewed; Region: aroK; PRK00131
1127134008973	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1127134008974	ADP binding site [chemical binding]; other site
1127134008975	magnesium binding site [ion binding]; other site
1127134008976	putative shikimate binding site; other site
1127134008977	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1127134008978	active site
1127134008979	dimer interface [polypeptide binding]; other site
1127134008980	metal binding site [ion binding]; metal-binding site
1127134008981	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1127134008982	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1127134008983	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134008984	catalytic residue [active]
1127134008985	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1127134008986	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1127134008987	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1127134008988	shikimate binding site; other site
1127134008989	NAD(P) binding site [chemical binding]; other site
1127134008990	YceG-like family; Region: YceG; pfam02618
1127134008991	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
1127134008992	dimerization interface [polypeptide binding]; other site
1127134008993	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1127134008994	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1127134008995	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1127134008996	motif 1; other site
1127134008997	active site
1127134008998	motif 2; other site
1127134008999	motif 3; other site
1127134009000	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1127134009001	DHHA1 domain; Region: DHHA1; pfam02272
1127134009002	recombination factor protein RarA; Reviewed; Region: PRK13342
1127134009003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134009004	Walker A motif; other site
1127134009005	ATP binding site [chemical binding]; other site
1127134009006	Walker B motif; other site
1127134009007	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1127134009008	PhoD-like phosphatase; Region: PhoD; pfam09423
1127134009009	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1127134009010	putative active site [active]
1127134009011	putative metal binding site [ion binding]; other site
1127134009012	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1127134009013	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1127134009014	substrate binding site [chemical binding]; other site
1127134009015	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1127134009016	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1127134009017	dimer interface [polypeptide binding]; other site
1127134009018	anticodon binding site; other site
1127134009019	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1127134009020	homodimer interface [polypeptide binding]; other site
1127134009021	motif 1; other site
1127134009022	active site
1127134009023	motif 2; other site
1127134009024	GAD domain; Region: GAD; pfam02938
1127134009025	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1127134009026	active site
1127134009027	motif 3; other site
1127134009028	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1127134009029	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1127134009030	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134009031	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1127134009032	NAD(P) binding site [chemical binding]; other site
1127134009033	active site
1127134009034	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134009035	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1127134009036	FeS/SAM binding site; other site
1127134009037	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1127134009038	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1127134009039	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1127134009040	dimer interface [polypeptide binding]; other site
1127134009041	PYR/PP interface [polypeptide binding]; other site
1127134009042	TPP binding site [chemical binding]; other site
1127134009043	substrate binding site [chemical binding]; other site
1127134009044	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1127134009045	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1127134009046	TPP-binding site [chemical binding]; other site
1127134009047	malate dehydrogenase; Provisional; Region: PRK05442
1127134009048	Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338
1127134009049	NAD(P) binding site [chemical binding]; other site
1127134009050	dimer interface [polypeptide binding]; other site
1127134009051	malate binding site [chemical binding]; other site
1127134009052	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1127134009053	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1127134009054	dimer interface [polypeptide binding]; other site
1127134009055	motif 1; other site
1127134009056	active site
1127134009057	motif 2; other site
1127134009058	motif 3; other site
1127134009059	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1127134009060	anticodon binding site; other site
1127134009061	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1127134009062	active site
1127134009063	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1127134009064	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1127134009065	Walker A motif; other site
1127134009066	ATP binding site [chemical binding]; other site
1127134009067	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1127134009068	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1127134009069	Peptidase family M23; Region: Peptidase_M23; pfam01551
1127134009070	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1127134009071	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134009072	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134009073	catalytic residue [active]
1127134009074	NlpC/P60 family; Region: NLPC_P60; cl17555
1127134009075	AAA-like domain; Region: AAA_10; pfam12846
1127134009076	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
1127134009077	Cutinase; Region: Cutinase; pfam01083
1127134009078	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
1127134009079	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1127134009080	Zn2+ binding site [ion binding]; other site
1127134009081	Mg2+ binding site [ion binding]; other site
1127134009082	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1127134009083	synthetase active site [active]
1127134009084	NTP binding site [chemical binding]; other site
1127134009085	metal binding site [ion binding]; metal-binding site
1127134009086	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1127134009087	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1127134009088	Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259
1127134009089	Archaeal ATPase; Region: Arch_ATPase; pfam01637
1127134009090	AAA domain; Region: AAA_14; pfam13173
1127134009091	adenine phosphoribosyltransferase; Provisional; Region: PRK02304
1127134009092	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1127134009093	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1127134009094	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1127134009095	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1127134009096	Protein export membrane protein; Region: SecD_SecF; pfam02355
1127134009097	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1127134009098	Protein export membrane protein; Region: SecD_SecF; cl14618
1127134009099	Preprotein translocase subunit; Region: YajC; pfam02699
1127134009100	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134009101	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134009102	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134009103	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134009104	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134009105	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
1127134009106	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134009107	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134009108	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1127134009109	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134009110	Walker A motif; other site
1127134009111	ATP binding site [chemical binding]; other site
1127134009112	Walker B motif; other site
1127134009113	arginine finger; other site
1127134009114	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1127134009115	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1127134009116	RuvA N terminal domain; Region: RuvA_N; pfam01330
1127134009117	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1127134009118	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
1127134009119	active site
1127134009120	putative DNA-binding cleft [nucleotide binding]; other site
1127134009121	dimer interface [polypeptide binding]; other site
1127134009122	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1127134009123	metal ion-dependent adhesion site (MIDAS); other site
1127134009124	Putative esterase; Region: Esterase; pfam00756
1127134009125	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1127134009126	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293
1127134009127	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1127134009128	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1127134009129	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1127134009130	putative ADP-ribose binding site [chemical binding]; other site
1127134009131	putative active site [active]
1127134009132	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134009133	dimerization interface [polypeptide binding]; other site
1127134009134	putative DNA binding site [nucleotide binding]; other site
1127134009135	putative Zn2+ binding site [ion binding]; other site
1127134009136	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
1127134009137	putative hydrophobic ligand binding site [chemical binding]; other site
1127134009138	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1127134009139	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134009140	NAD binding site [chemical binding]; other site
1127134009141	substrate binding site [chemical binding]; other site
1127134009142	putative active site [active]
1127134009143	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134009144	putative DNA binding site [nucleotide binding]; other site
1127134009145	putative Zn2+ binding site [ion binding]; other site
1127134009146	hypothetical protein; Validated; Region: PRK00110
1127134009147	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1127134009148	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
1127134009149	predicted active site [active]
1127134009150	catalytic triad [active]
1127134009151	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1127134009152	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1127134009153	active site
1127134009154	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1127134009155	catalytic triad [active]
1127134009156	dimer interface [polypeptide binding]; other site
1127134009157	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1127134009158	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1127134009159	active site
1127134009160	multimer interface [polypeptide binding]; other site
1127134009161	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
1127134009162	nudix motif; other site
1127134009163	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134009164	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1127134009165	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1127134009166	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1127134009167	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1127134009168	putative acyl-acceptor binding pocket; other site
1127134009169	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1127134009170	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
1127134009171	nucleotide binding site/active site [active]
1127134009172	HIT family signature motif; other site
1127134009173	catalytic residue [active]
1127134009174	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1127134009175	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1127134009176	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1127134009177	active site
1127134009178	dimer interface [polypeptide binding]; other site
1127134009179	motif 1; other site
1127134009180	motif 2; other site
1127134009181	motif 3; other site
1127134009182	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1127134009183	anticodon binding site; other site
1127134009184	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1127134009185	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1127134009186	Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870
1127134009187	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1127134009188	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1127134009189	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
1127134009190	active site clefts [active]
1127134009191	zinc binding site [ion binding]; other site
1127134009192	dimer interface [polypeptide binding]; other site
1127134009193	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134009194	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134009195	Secretory lipase; Region: LIP; pfam03583
1127134009196	acyl-CoA synthetase; Validated; Region: PRK07788
1127134009197	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134009198	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134009199	active site
1127134009200	CoA binding site [chemical binding]; other site
1127134009201	AMP binding site [chemical binding]; other site
1127134009202	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
1127134009203	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134009204	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134009205	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460
1127134009206	putative substrate binding pocket [chemical binding]; other site
1127134009207	putative dimerization interface [polypeptide binding]; other site
1127134009208	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134009209	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134009210	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1127134009211	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134009212	Coenzyme A binding pocket [chemical binding]; other site
1127134009213	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1127134009214	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1127134009215	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1127134009216	AFG1-like ATPase; Region: AFG1_ATPase; pfam03969
1127134009217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1127134009218	Walker A motif; other site
1127134009219	ATP binding site [chemical binding]; other site
1127134009220	Walker B motif; other site
1127134009221	hypothetical protein; Provisional; Region: PRK14059
1127134009222	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1127134009223	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134009224	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134009225	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
1127134009226	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1127134009227	SelR domain; Region: SelR; pfam01641
1127134009228	Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253
1127134009229	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134009230	dimerization interface [polypeptide binding]; other site
1127134009231	putative DNA binding site [nucleotide binding]; other site
1127134009232	putative Zn2+ binding site [ion binding]; other site
1127134009233	Cation efflux family; Region: Cation_efflux; cl00316
1127134009234	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1127134009235	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134009236	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1127134009237	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1127134009238	heme-binding site [chemical binding]; other site
1127134009239	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1127134009240	FAD binding pocket [chemical binding]; other site
1127134009241	FAD binding motif [chemical binding]; other site
1127134009242	phosphate binding motif [ion binding]; other site
1127134009243	beta-alpha-beta structure motif; other site
1127134009244	NAD binding pocket [chemical binding]; other site
1127134009245	Heme binding  pocket [chemical binding]; other site
1127134009246	Transcriptional regulator; Region: Rrf2; cl17282
1127134009247	Rrf2 family protein; Region: rrf2_super; TIGR00738
1127134009248	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1127134009249	substrate binding site [chemical binding]; other site
1127134009250	active site
1127134009251	Protein of unknown function (DUF3000); Region: DUF3000; pfam11452
1127134009252	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1127134009253	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1127134009254	catalytic site [active]
1127134009255	putative active site [active]
1127134009256	putative substrate binding site [chemical binding]; other site
1127134009257	Helicase and RNase D C-terminal; Region: HRDC; smart00341
1127134009258	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134009259	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1127134009260	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1127134009261	TPP-binding site; other site
1127134009262	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1127134009263	PYR/PP interface [polypeptide binding]; other site
1127134009264	dimer interface [polypeptide binding]; other site
1127134009265	TPP binding site [chemical binding]; other site
1127134009266	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1127134009267	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1127134009268	TRAM domain; Region: TRAM; pfam01938
1127134009269	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1127134009270	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1127134009271	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1127134009272	TrkA-N domain; Region: TrkA_N; pfam02254
1127134009273	TrkA-C domain; Region: TrkA_C; pfam02080
1127134009274	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1127134009275	TrkA-N domain; Region: TrkA_N; pfam02254
1127134009276	TrkA-C domain; Region: TrkA_C; pfam02080
1127134009277	RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648
1127134009278	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134009279	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134009280	DNA binding residues [nucleotide binding]
1127134009281	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
1127134009282	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
1127134009283	generic binding surface I; other site
1127134009284	generic binding surface II; other site
1127134009285	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134009286	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
1127134009287	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1127134009288	trimer interface [polypeptide binding]; other site
1127134009289	active site
1127134009290	Protein of unknown function (DUF3093); Region: DUF3093; pfam11292
1127134009291	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
1127134009292	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1127134009293	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1127134009294	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1127134009295	active site
1127134009296	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1127134009297	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1127134009298	nucleotide binding site [chemical binding]; other site
1127134009299	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1127134009300	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1127134009301	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134009302	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1127134009303	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134009304	DNA binding residues [nucleotide binding]
1127134009305	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1127134009306	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1127134009307	ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465
1127134009308	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1127134009309	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1127134009310	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1127134009311	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1127134009312	Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490
1127134009313	TrkA-C domain; Region: TrkA_C; pfam02080
1127134009314	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134009315	Histidine kinase; Region: HisKA_3; pfam07730
1127134009316	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134009317	ATP binding site [chemical binding]; other site
1127134009318	Mg2+ binding site [ion binding]; other site
1127134009319	G-X-G motif; other site
1127134009320	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134009321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134009322	active site
1127134009323	phosphorylation site [posttranslational modification]
1127134009324	intermolecular recognition site; other site
1127134009325	dimerization interface [polypeptide binding]; other site
1127134009326	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134009327	dimerization interface [polypeptide binding]; other site
1127134009328	DNA binding residues [nucleotide binding]
1127134009329	Protein of unknown function (DUF952); Region: DUF952; pfam06108
1127134009330	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134009331	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134009332	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134009333	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1127134009334	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134009335	ATP binding site [chemical binding]; other site
1127134009336	putative Mg++ binding site [ion binding]; other site
1127134009337	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134009338	nucleotide binding region [chemical binding]; other site
1127134009339	ATP-binding site [chemical binding]; other site
1127134009340	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1127134009341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134009342	S-adenosylmethionine binding site [chemical binding]; other site
1127134009343	Cupin domain; Region: Cupin_2; pfam07883
1127134009344	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134009345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134009346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134009347	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1127134009348	NAD(P) binding site [chemical binding]; other site
1127134009349	active site
1127134009350	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134009351	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134009352	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1127134009353	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134009354	ATP binding site [chemical binding]; other site
1127134009355	putative Mg++ binding site [ion binding]; other site
1127134009356	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1127134009357	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
1127134009358	Protein of unknown function (DUF3099); Region: DUF3099; pfam11298
1127134009359	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134009360	S-adenosylmethionine binding site [chemical binding]; other site
1127134009361	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
1127134009362	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1127134009363	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134009364	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1127134009365	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134009366	DNA binding residues [nucleotide binding]
1127134009367	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1127134009368	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134009369	Coenzyme A binding pocket [chemical binding]; other site
1127134009370	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
1127134009371	CoA binding domain; Region: CoA_binding_2; pfam13380
1127134009372	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1127134009373	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1127134009374	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1127134009375	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1127134009376	active site
1127134009377	Zn binding site [ion binding]; other site
1127134009378	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1127134009379	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1127134009380	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1127134009381	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1127134009382	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1127134009383	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1127134009384	NAD binding site [chemical binding]; other site
1127134009385	homodimer interface [polypeptide binding]; other site
1127134009386	active site
1127134009387	substrate binding site [chemical binding]; other site
1127134009388	Domain of unknown function (DUF4192); Region: DUF4192; pfam13830
1127134009389	PAC2 family; Region: PAC2; pfam09754
1127134009390	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134009391	ATP binding site [chemical binding]; other site
1127134009392	putative Mg++ binding site [ion binding]; other site
1127134009393	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134009394	nucleotide binding region [chemical binding]; other site
1127134009395	ATP-binding site [chemical binding]; other site
1127134009396	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
1127134009397	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1127134009398	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1127134009399	dimer interface [polypeptide binding]; other site
1127134009400	active site
1127134009401	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134009402	catalytic residues [active]
1127134009403	substrate binding site [chemical binding]; other site
1127134009404	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675
1127134009405	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134009406	S-adenosylmethionine binding site [chemical binding]; other site
1127134009407	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134009408	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1127134009409	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1127134009410	dimerization interface [polypeptide binding]; other site
1127134009411	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1127134009412	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1127134009413	dimer interface [polypeptide binding]; other site
1127134009414	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1127134009415	catalytic triad [active]
1127134009416	peroxidatic and resolving cysteines [active]
1127134009417	alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777
1127134009418	alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778
1127134009419	Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567
1127134009420	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161
1127134009421	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134009422	inhibitor-cofactor binding pocket; inhibition site
1127134009423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134009424	catalytic residue [active]
1127134009425	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
1127134009426	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134009427	ATP binding site [chemical binding]; other site
1127134009428	putative Mg++ binding site [ion binding]; other site
1127134009429	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134009430	nucleotide binding region [chemical binding]; other site
1127134009431	ATP-binding site [chemical binding]; other site
1127134009432	Helicase associated domain (HA2); Region: HA2; pfam04408
1127134009433	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
1127134009434	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
1127134009435	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1127134009436	ATP cone domain; Region: ATP-cone; pfam03477
1127134009437	LexA repressor; Validated; Region: PRK00215
1127134009438	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1127134009439	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1127134009440	Catalytic site [active]
1127134009441	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1127134009442	short chain dehydrogenase; Provisional; Region: PRK07814
1127134009443	classical (c) SDRs; Region: SDR_c; cd05233
1127134009444	NAD(P) binding site [chemical binding]; other site
1127134009445	active site
1127134009446	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
1127134009447	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1127134009448	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134009449	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134009450	active site
1127134009451	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134009452	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1127134009453	putative acyl-acceptor binding pocket; other site
1127134009454	GTPases [General function prediction only]; Region: HflX; COG2262
1127134009455	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1127134009456	HflX GTPase family; Region: HflX; cd01878
1127134009457	G1 box; other site
1127134009458	GTP/Mg2+ binding site [chemical binding]; other site
1127134009459	Switch I region; other site
1127134009460	G2 box; other site
1127134009461	G3 box; other site
1127134009462	Switch II region; other site
1127134009463	G4 box; other site
1127134009464	G5 box; other site
1127134009465	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1127134009466	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1127134009467	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1127134009468	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1127134009469	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1127134009470	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1127134009471	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1127134009472	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
1127134009473	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1127134009474	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1127134009475	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
1127134009476	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
1127134009477	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1127134009478	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134009479	FeS/SAM binding site; other site
1127134009480	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1127134009481	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1127134009482	Walker A/P-loop; other site
1127134009483	ATP binding site [chemical binding]; other site
1127134009484	Q-loop/lid; other site
1127134009485	ABC transporter signature motif; other site
1127134009486	Walker B; other site
1127134009487	D-loop; other site
1127134009488	H-loop/switch region; other site
1127134009489	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134009490	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1127134009491	substrate binding pocket [chemical binding]; other site
1127134009492	membrane-bound complex binding site; other site
1127134009493	hinge residues; other site
1127134009494	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1127134009495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134009496	dimer interface [polypeptide binding]; other site
1127134009497	conserved gate region; other site
1127134009498	putative PBP binding loops; other site
1127134009499	ABC-ATPase subunit interface; other site
1127134009500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134009501	dimer interface [polypeptide binding]; other site
1127134009502	conserved gate region; other site
1127134009503	putative PBP binding loops; other site
1127134009504	ABC-ATPase subunit interface; other site
1127134009505	recombination regulator RecX; Reviewed; Region: recX; PRK00117
1127134009506	recombinase A; Provisional; Region: recA; PRK09354
1127134009507	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1127134009508	hexamer interface [polypeptide binding]; other site
1127134009509	Walker A motif; other site
1127134009510	ATP binding site [chemical binding]; other site
1127134009511	Walker B motif; other site
1127134009512	Protein of unknown function (DUF1348); Region: DUF1348; pfam07080
1127134009513	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134009514	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1127134009515	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1127134009516	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134009517	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134009518	active site
1127134009519	metal binding site [ion binding]; metal-binding site
1127134009520	CGNR zinc finger; Region: zf-CGNR; pfam11706
1127134009521	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134009522	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
1127134009523	active site
1127134009524	ATP binding site [chemical binding]; other site
1127134009525	antibiotic binding site [chemical binding]; other site
1127134009526	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
1127134009527	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1127134009528	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1127134009529	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
1127134009530	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134009531	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134009532	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134009533	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134009534	active site
1127134009535	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1127134009536	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134009537	sequence-specific DNA binding site [nucleotide binding]; other site
1127134009538	salt bridge; other site
1127134009539	Competence-damaged protein; Region: CinA; pfam02464
1127134009540	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1127134009541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134009542	Coenzyme A binding pocket [chemical binding]; other site
1127134009543	YCII-related domain; Region: YCII; cl00999
1127134009544	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
1127134009545	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1127134009546	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134009547	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1127134009548	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1127134009549	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134009550	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1127134009551	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1127134009552	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1127134009553	dimer interface [polypeptide binding]; other site
1127134009554	active site
1127134009555	catalytic residue [active]
1127134009556	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1127134009557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1127134009558	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1127134009559	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134009560	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134009561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134009562	active site
1127134009563	phosphorylation site [posttranslational modification]
1127134009564	intermolecular recognition site; other site
1127134009565	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134009566	DNA binding residues [nucleotide binding]
1127134009567	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1127134009568	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134009569	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1127134009570	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1127134009571	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1127134009572	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134009573	active site
1127134009574	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460
1127134009575	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134009576	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134009577	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134009578	putative DNA binding site [nucleotide binding]; other site
1127134009579	helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418
1127134009580	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1127134009581	TPR motif; other site
1127134009582	binding surface
1127134009583	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1127134009584	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1127134009585	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1127134009586	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
1127134009587	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
1127134009588	oligomer interface [polypeptide binding]; other site
1127134009589	RNA binding site [nucleotide binding]; other site
1127134009590	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1127134009591	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1127134009592	RNase E interface [polypeptide binding]; other site
1127134009593	trimer interface [polypeptide binding]; other site
1127134009594	active site
1127134009595	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1127134009596	putative nucleic acid binding region [nucleotide binding]; other site
1127134009597	G-X-X-G motif; other site
1127134009598	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1127134009599	RNA binding site [nucleotide binding]; other site
1127134009600	domain interface; other site
1127134009601	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1127134009602	16S/18S rRNA binding site [nucleotide binding]; other site
1127134009603	S13e-L30e interaction site [polypeptide binding]; other site
1127134009604	25S rRNA binding site [nucleotide binding]; other site
1127134009605	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1127134009606	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1127134009607	active site
1127134009608	Riboflavin kinase; Region: Flavokinase; smart00904
1127134009609	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
1127134009610	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134009611	putative DNA binding site [nucleotide binding]; other site
1127134009612	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1127134009613	FeoA domain; Region: FeoA; pfam04023
1127134009614	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
1127134009615	tartrate dehydrogenase; Provisional; Region: PRK08194
1127134009616	succinic semialdehyde dehydrogenase; Region: PLN02278
1127134009617	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1127134009618	tetramerization interface [polypeptide binding]; other site
1127134009619	NAD(P) binding site [chemical binding]; other site
1127134009620	catalytic residues [active]
1127134009621	4-aminobutyrate aminotransferase; Provisional; Region: PRK08117
1127134009622	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134009623	inhibitor-cofactor binding pocket; inhibition site
1127134009624	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134009625	catalytic residue [active]
1127134009626	Protein of unknown function (DUF3830); Region: DUF3830; pfam12903
1127134009627	putative amidase; Provisional; Region: PRK06169
1127134009628	Amidase; Region: Amidase; pfam01425
1127134009629	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
1127134009630	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1127134009631	NAD binding site [chemical binding]; other site
1127134009632	ligand binding site [chemical binding]; other site
1127134009633	catalytic site [active]
1127134009634	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1127134009635	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1127134009636	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1127134009637	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134009638	DNA-binding site [nucleotide binding]; DNA binding site
1127134009639	FCD domain; Region: FCD; pfam07729
1127134009640	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
1127134009641	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134009642	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134009643	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
1127134009644	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1127134009645	RNA binding site [nucleotide binding]; other site
1127134009646	active site
1127134009647	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
1127134009648	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1127134009649	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1127134009650	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1127134009651	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1127134009652	active site
1127134009653	metal binding site [ion binding]; metal-binding site
1127134009654	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1127134009655	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1127134009656	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1127134009657	DHH family; Region: DHH; pfam01368
1127134009658	DHHA1 domain; Region: DHHA1; pfam02272
1127134009659	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1127134009660	Protein of unknown function (DUF503); Region: DUF503; pfam04456
1127134009661	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1127134009662	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1127134009663	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
1127134009664	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1127134009665	G1 box; other site
1127134009666	putative GEF interaction site [polypeptide binding]; other site
1127134009667	GTP/Mg2+ binding site [chemical binding]; other site
1127134009668	Switch I region; other site
1127134009669	G2 box; other site
1127134009670	G3 box; other site
1127134009671	Switch II region; other site
1127134009672	G4 box; other site
1127134009673	G5 box; other site
1127134009674	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1127134009675	Translation-initiation factor 2; Region: IF-2; pfam11987
1127134009676	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1127134009677	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1127134009678	NusA N-terminal domain; Region: NusA_N; pfam08529
1127134009679	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1127134009680	RNA binding site [nucleotide binding]; other site
1127134009681	homodimer interface [polypeptide binding]; other site
1127134009682	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1127134009683	G-X-X-G motif; other site
1127134009684	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1127134009685	G-X-X-G motif; other site
1127134009686	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1127134009687	Sm and related proteins; Region: Sm_like; cl00259
1127134009688	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1127134009689	putative oligomer interface [polypeptide binding]; other site
1127134009690	putative RNA binding site [nucleotide binding]; other site
1127134009691	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1127134009692	dinuclear metal binding motif [ion binding]; other site
1127134009693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134009694	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134009695	NAD(P) binding site [chemical binding]; other site
1127134009696	active site
1127134009697	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134009698	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1127134009699	active site
1127134009700	hypothetical protein; Validated; Region: PRK07121
1127134009701	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134009702	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1127134009703	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1127134009704	dimer interface [polypeptide binding]; other site
1127134009705	motif 1; other site
1127134009706	active site
1127134009707	motif 2; other site
1127134009708	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1127134009709	putative deacylase active site [active]
1127134009710	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1127134009711	active site
1127134009712	motif 3; other site
1127134009713	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1127134009714	anticodon binding site; other site
1127134009715	ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995
1127134009716	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134009717	substrate binding pocket [chemical binding]; other site
1127134009718	membrane-bound complex binding site; other site
1127134009719	hinge residues; other site
1127134009720	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134009721	dimer interface [polypeptide binding]; other site
1127134009722	conserved gate region; other site
1127134009723	putative PBP binding loops; other site
1127134009724	ABC-ATPase subunit interface; other site
1127134009725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134009726	dimer interface [polypeptide binding]; other site
1127134009727	conserved gate region; other site
1127134009728	putative PBP binding loops; other site
1127134009729	ABC-ATPase subunit interface; other site
1127134009730	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1127134009731	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1127134009732	Walker A/P-loop; other site
1127134009733	ATP binding site [chemical binding]; other site
1127134009734	Q-loop/lid; other site
1127134009735	ABC transporter signature motif; other site
1127134009736	Walker B; other site
1127134009737	D-loop; other site
1127134009738	H-loop/switch region; other site
1127134009739	hypothetical protein; Validated; Region: PRK02101
1127134009740	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1127134009741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134009742	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134009743	putative substrate translocation pore; other site
1127134009744	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1127134009745	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1127134009746	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1127134009747	homodimer interface [polypeptide binding]; other site
1127134009748	active site
1127134009749	SAM binding site [chemical binding]; other site
1127134009750	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134009751	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134009752	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1127134009753	putative active site [active]
1127134009754	putative substrate binding site [chemical binding]; other site
1127134009755	ATP binding site [chemical binding]; other site
1127134009756	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1127134009757	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1127134009758	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1127134009759	catalytic triad [active]
1127134009760	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1127134009761	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1127134009762	Walker A motif; other site
1127134009763	homodimer interface [polypeptide binding]; other site
1127134009764	ATP binding site [chemical binding]; other site
1127134009765	hydroxycobalamin binding site [chemical binding]; other site
1127134009766	Walker B motif; other site
1127134009767	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
1127134009768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134009769	Walker A motif; other site
1127134009770	ATP binding site [chemical binding]; other site
1127134009771	Walker B motif; other site
1127134009772	arginine finger; other site
1127134009773	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1127134009774	metal ion-dependent adhesion site (MIDAS); other site
1127134009775	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134009776	Coenzyme A binding pocket [chemical binding]; other site
1127134009777	malate:quinone oxidoreductase; Validated; Region: PRK05257
1127134009778	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1127134009779	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1127134009780	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134009781	cobyric acid synthase; Provisional; Region: PRK00784
1127134009782	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1127134009783	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1127134009784	catalytic triad [active]
1127134009785	methionine aminopeptidase; Provisional; Region: PRK12318
1127134009786	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1127134009787	active site
1127134009788	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1127134009789	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134009790	DNA-binding site [nucleotide binding]; DNA binding site
1127134009791	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1127134009792	FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed
1127134009793	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1127134009794	phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351
1127134009795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134009796	motif II; other site
1127134009797	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1127134009798	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1127134009799	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1127134009800	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134009801	Walker A/P-loop; other site
1127134009802	ATP binding site [chemical binding]; other site
1127134009803	Q-loop/lid; other site
1127134009804	ABC transporter signature motif; other site
1127134009805	Walker B; other site
1127134009806	D-loop; other site
1127134009807	H-loop/switch region; other site
1127134009808	TOBE domain; Region: TOBE_2; pfam08402
1127134009809	2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050
1127134009810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134009811	dimer interface [polypeptide binding]; other site
1127134009812	conserved gate region; other site
1127134009813	putative PBP binding loops; other site
1127134009814	ABC-ATPase subunit interface; other site
1127134009815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134009816	dimer interface [polypeptide binding]; other site
1127134009817	conserved gate region; other site
1127134009818	putative PBP binding loops; other site
1127134009819	ABC-ATPase subunit interface; other site
1127134009820	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1127134009821	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134009822	Cytochrome P450; Region: p450; cl12078
1127134009823	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134009824	active site
1127134009825	TIGR03085 family protein; Region: TIGR03085
1127134009826	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1127134009827	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1127134009828	LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037
1127134009829	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134009830	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134009831	non-specific DNA binding site [nucleotide binding]; other site
1127134009832	salt bridge; other site
1127134009833	sequence-specific DNA binding site [nucleotide binding]; other site
1127134009834	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134009835	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134009836	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134009837	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134009838	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1127134009839	classical (c) SDRs; Region: SDR_c; cd05233
1127134009840	NAD(P) binding site [chemical binding]; other site
1127134009841	active site
1127134009842	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134009843	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134009844	TIGR03118 family protein; Region: PEPCTERM_chp_1
1127134009845	nitrobindin heme-binding domain; Region: nitrobindin; cd07828
1127134009846	heme-binding site [chemical binding]; other site
1127134009847	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1127134009848	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1127134009849	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1127134009850	Predicted acetyltransferase [General function prediction only]; Region: COG3393
1127134009851	Domain of unknown function (DUF4081); Region: DUF4081; pfam13312
1127134009852	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1127134009853	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1127134009854	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1127134009855	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1127134009856	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1127134009857	active site
1127134009858	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1127134009859	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1127134009860	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1127134009861	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1127134009862	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1127134009863	Protein of unknown function (DUF2631); Region: DUF2631; pfam10939
1127134009864	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
1127134009865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134009866	FeS/SAM binding site; other site
1127134009867	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1127134009868	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1127134009869	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1127134009870	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1127134009871	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1127134009872	hinge region; other site
1127134009873	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1127134009874	putative nucleotide binding site [chemical binding]; other site
1127134009875	uridine monophosphate binding site [chemical binding]; other site
1127134009876	homohexameric interface [polypeptide binding]; other site
1127134009877	elongation factor Ts; Provisional; Region: tsf; PRK09377
1127134009878	UBA/TS-N domain; Region: UBA; pfam00627
1127134009879	Elongation factor TS; Region: EF_TS; pfam00889
1127134009880	Elongation factor TS; Region: EF_TS; pfam00889
1127134009881	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1127134009882	rRNA interaction site [nucleotide binding]; other site
1127134009883	S8 interaction site; other site
1127134009884	putative laminin-1 binding site; other site
1127134009885	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1127134009886	Peptidase family M23; Region: Peptidase_M23; pfam01551
1127134009887	Domain of unknown function (DUF1990); Region: DUF1990; pfam09348
1127134009888	Domain of unknown function (DUF202); Region: DUF202; cl09954
1127134009889	Domain of unknown function (DUF202); Region: DUF202; cl09954
1127134009890	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1127134009891	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134009892	active site
1127134009893	DNA binding site [nucleotide binding]
1127134009894	Int/Topo IB signature motif; other site
1127134009895	DNA protecting protein DprA; Region: dprA; TIGR00732
1127134009896	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1127134009897	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1127134009898	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1127134009899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134009900	Walker A motif; other site
1127134009901	ATP binding site [chemical binding]; other site
1127134009902	Walker B motif; other site
1127134009903	arginine finger; other site
1127134009904	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1127134009905	hypothetical protein; Reviewed; Region: PRK12497
1127134009906	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
1127134009907	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1127134009908	RNA/DNA hybrid binding site [nucleotide binding]; other site
1127134009909	active site
1127134009910	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1127134009911	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1127134009912	Catalytic site [active]
1127134009913	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
1127134009914	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1127134009915	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1127134009916	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1127134009917	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1127134009918	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1127134009919	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1127134009920	RNA binding site [nucleotide binding]; other site
1127134009921	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1127134009922	active site
1127134009923	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134009924	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134009925	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134009926	DNA binding residues [nucleotide binding]
1127134009927	dimerization interface [polypeptide binding]; other site
1127134009928	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1127134009929	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134009930	acyl-activating enzyme (AAE) consensus motif; other site
1127134009931	AMP binding site [chemical binding]; other site
1127134009932	active site
1127134009933	CoA binding site [chemical binding]; other site
1127134009934	AMP-binding domain protein; Validated; Region: PRK08315
1127134009935	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134009936	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
1127134009937	acyl-activating enzyme (AAE) consensus motif; other site
1127134009938	putative AMP binding site [chemical binding]; other site
1127134009939	putative active site [active]
1127134009940	putative CoA binding site [chemical binding]; other site
1127134009941	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1127134009942	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1127134009943	RimM N-terminal domain; Region: RimM; pfam01782
1127134009944	PRC-barrel domain; Region: PRC; pfam05239
1127134009945	hypothetical protein; Provisional; Region: PRK02821
1127134009946	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1127134009947	G-X-X-G motif; other site
1127134009948	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
1127134009949	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1127134009950	putative active site [active]
1127134009951	signal recognition particle protein; Provisional; Region: PRK10867
1127134009952	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1127134009953	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1127134009954	P loop; other site
1127134009955	GTP binding site [chemical binding]; other site
1127134009956	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1127134009957	PII uridylyl-transferase; Provisional; Region: PRK03381
1127134009958	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1127134009959	metal binding triad [ion binding]; metal-binding site
1127134009960	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1127134009961	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
1127134009962	ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873
1127134009963	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1127134009964	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1127134009965	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1127134009966	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1127134009967	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1127134009968	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1127134009969	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
1127134009970	Phage shock protein B; Region: PspB; cl05946
1127134009971	AAA domain; Region: AAA_23; pfam13476
1127134009972	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1127134009973	Walker A/P-loop; other site
1127134009974	ATP binding site [chemical binding]; other site
1127134009975	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1127134009976	ABC transporter signature motif; other site
1127134009977	Walker B; other site
1127134009978	D-loop; other site
1127134009979	H-loop/switch region; other site
1127134009980	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134009981	2TM domain; Region: 2TM; pfam13239
1127134009982	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1127134009983	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
1127134009984	Acylphosphatase; Region: Acylphosphatase; cl00551
1127134009985	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1127134009986	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
1127134009987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134009988	active site
1127134009989	phosphorylation site [posttranslational modification]
1127134009990	intermolecular recognition site; other site
1127134009991	dimerization interface [polypeptide binding]; other site
1127134009992	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134009993	DNA binding site [nucleotide binding]
1127134009994	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1127134009995	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1127134009996	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1127134009997	Ligand Binding Site [chemical binding]; other site
1127134009998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134009999	dimer interface [polypeptide binding]; other site
1127134010000	phosphorylation site [posttranslational modification]
1127134010001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134010002	ATP binding site [chemical binding]; other site
1127134010003	Mg2+ binding site [ion binding]; other site
1127134010004	G-X-G motif; other site
1127134010005	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1127134010006	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1127134010007	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134010008	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1127134010009	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1127134010010	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1127134010011	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1127134010012	PBP superfamily domain; Region: PBP_like_2; cl17296
1127134010013	hypothetical protein; Provisional; Region: PRK07945
1127134010014	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1127134010015	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
1127134010016	active site
1127134010017	RibD C-terminal domain; Region: RibD_C; cl17279
1127134010018	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134010019	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1127134010020	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1127134010021	DNA binding site [nucleotide binding]
1127134010022	catalytic residue [active]
1127134010023	H2TH interface [polypeptide binding]; other site
1127134010024	putative catalytic residues [active]
1127134010025	turnover-facilitating residue; other site
1127134010026	intercalation triad [nucleotide binding]; other site
1127134010027	8OG recognition residue [nucleotide binding]; other site
1127134010028	putative reading head residues; other site
1127134010029	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1127134010030	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1127134010031	ribonuclease III; Reviewed; Region: rnc; PRK00102
1127134010032	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1127134010033	dimerization interface [polypeptide binding]; other site
1127134010034	active site
1127134010035	metal binding site [ion binding]; metal-binding site
1127134010036	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1127134010037	dsRNA binding site [nucleotide binding]; other site
1127134010038	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1127134010039	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1127134010040	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1127134010041	GtrA-like protein; Region: GtrA; pfam04138
1127134010042	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1127134010043	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1127134010044	active site
1127134010045	(T/H)XGH motif; other site
1127134010046	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1127134010047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134010048	S-adenosylmethionine binding site [chemical binding]; other site
1127134010049	pyruvate carboxylase; Reviewed; Region: PRK12999
1127134010050	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134010051	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134010052	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1127134010053	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1127134010054	active site
1127134010055	catalytic residues [active]
1127134010056	metal binding site [ion binding]; metal-binding site
1127134010057	homodimer binding site [polypeptide binding]; other site
1127134010058	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134010059	carboxyltransferase (CT) interaction site; other site
1127134010060	biotinylation site [posttranslational modification]; other site
1127134010061	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1127134010062	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1127134010063	active site
1127134010064	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1127134010065	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1127134010066	THF binding site; other site
1127134010067	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1127134010068	substrate binding site [chemical binding]; other site
1127134010069	THF binding site; other site
1127134010070	zinc-binding site [ion binding]; other site
1127134010071	citrate synthase; Provisional; Region: PRK14033
1127134010072	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
1127134010073	oxalacetate binding site [chemical binding]; other site
1127134010074	citrylCoA binding site [chemical binding]; other site
1127134010075	coenzyme A binding site [chemical binding]; other site
1127134010076	catalytic triad [active]
1127134010077	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1127134010078	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1127134010079	tetramer interface [polypeptide binding]; other site
1127134010080	active site
1127134010081	Mg2+/Mn2+ binding site [ion binding]; other site
1127134010082	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
1127134010083	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134010084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134010085	sequence-specific DNA binding site [nucleotide binding]; other site
1127134010086	salt bridge; other site
1127134010087	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1127134010088	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1127134010089	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1127134010090	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1127134010091	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1127134010092	generic binding surface II; other site
1127134010093	ssDNA binding site; other site
1127134010094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134010095	ATP binding site [chemical binding]; other site
1127134010096	putative Mg++ binding site [ion binding]; other site
1127134010097	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134010098	nucleotide binding region [chemical binding]; other site
1127134010099	ATP-binding site [chemical binding]; other site
1127134010100	DAK2 domain; Region: Dak2; cl03685
1127134010101	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1127134010102	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
1127134010103	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : putative enzyme
1127134010104	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134010105	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1127134010106	catalytic site [active]
1127134010107	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1127134010108	ligand binding site [chemical binding]; other site
1127134010109	active site
1127134010110	UGI interface [polypeptide binding]; other site
1127134010111	catalytic site [active]
1127134010112	thiamine monophosphate kinase; Provisional; Region: PRK05731
1127134010113	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1127134010114	ATP binding site [chemical binding]; other site
1127134010115	dimerization interface [polypeptide binding]; other site
1127134010116	Protein of unknown function (DUF3515); Region: DUF3515; pfam12028
1127134010117	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1127134010118	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1127134010119	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134010120	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1127134010121	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1127134010122	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1127134010123	2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552
1127134010124	polyphosphate kinase; Provisional; Region: PRK05443
1127134010125	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1127134010126	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1127134010127	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1127134010128	putative domain interface [polypeptide binding]; other site
1127134010129	putative active site [active]
1127134010130	catalytic site [active]
1127134010131	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1127134010132	putative domain interface [polypeptide binding]; other site
1127134010133	putative active site [active]
1127134010134	catalytic site [active]
1127134010135	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1127134010136	active site
1127134010137	Ap6A binding site [chemical binding]; other site
1127134010138	nudix motif; other site
1127134010139	metal binding site [ion binding]; metal-binding site
1127134010140	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134010141	catalytic core [active]
1127134010142	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1127134010143	IHF - DNA interface [nucleotide binding]; other site
1127134010144	IHF dimer interface [polypeptide binding]; other site
1127134010145	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1127134010146	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1127134010147	substrate binding site [chemical binding]; other site
1127134010148	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1127134010149	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1127134010150	substrate binding site [chemical binding]; other site
1127134010151	ligand binding site [chemical binding]; other site
1127134010152	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1127134010153	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1127134010154	Bacterial transcriptional regulator; Region: IclR; pfam01614
1127134010155	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1127134010156	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1127134010157	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1127134010158	HIGH motif; other site
1127134010159	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1127134010160	active site
1127134010161	KMSKS motif; other site
1127134010162	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
1127134010163	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1127134010164	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1127134010165	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134010166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010167	3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437
1127134010168	tartrate dehydrogenase; Region: TTC; TIGR02089
1127134010169	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1127134010170	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1127134010171	ligand binding site [chemical binding]; other site
1127134010172	NAD binding site [chemical binding]; other site
1127134010173	dimerization interface [polypeptide binding]; other site
1127134010174	catalytic site [active]
1127134010175	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1127134010176	putative L-serine binding site [chemical binding]; other site
1127134010177	amino acid transporter; Region: 2A0306; TIGR00909
1127134010178	amino acid transporter; Region: 2A0306; TIGR00909
1127134010179	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1127134010180	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134010181	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134010182	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010183	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010184	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1127134010185	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1127134010186	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1127134010187	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1127134010188	NAD(P) binding site [chemical binding]; other site
1127134010189	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134010190	acyl-CoA synthetase; Provisional; Region: PRK13388
1127134010191	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010192	acyl-activating enzyme (AAE) consensus motif; other site
1127134010193	AMP binding site [chemical binding]; other site
1127134010194	active site
1127134010195	CoA binding site [chemical binding]; other site
1127134010196	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010197	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010198	short chain dehydrogenase; Provisional; Region: PRK05854
1127134010199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134010200	NAD(P) binding site [chemical binding]; other site
1127134010201	active site
1127134010202	probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621
1127134010203	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1127134010204	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134010205	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1127134010206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134010207	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1127134010208	Walker A motif; other site
1127134010209	ATP binding site [chemical binding]; other site
1127134010210	Walker B motif; other site
1127134010211	arginine finger; other site
1127134010212	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1127134010213	MoxR-like ATPases [General function prediction only]; Region: COG0714
1127134010214	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1127134010215	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
1127134010216	conserved cys residue [active]
1127134010217	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134010218	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134010219	active site
1127134010220	metal binding site [ion binding]; metal-binding site
1127134010221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1127134010222	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1127134010223	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1127134010224	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1127134010225	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1127134010226	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1127134010227	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1127134010228	putative valine binding site [chemical binding]; other site
1127134010229	dimer interface [polypeptide binding]; other site
1127134010230	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1127134010231	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
1127134010232	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1127134010233	PYR/PP interface [polypeptide binding]; other site
1127134010234	dimer interface [polypeptide binding]; other site
1127134010235	TPP binding site [chemical binding]; other site
1127134010236	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1127134010237	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1127134010238	TPP-binding site [chemical binding]; other site
1127134010239	dimer interface [polypeptide binding]; other site
1127134010240	Protein of unknown function (DUF2581); Region: DUF2581; pfam10756
1127134010241	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1127134010242	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1127134010243	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
1127134010244	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1127134010245	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1127134010246	GatB domain; Region: GatB_Yqey; smart00845
1127134010247	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134010248	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134010249	6-phosphofructokinase; Provisional; Region: PRK03202
1127134010250	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1127134010251	dimerization interface [polypeptide binding]; other site
1127134010252	allosteric effector site; other site
1127134010253	active site
1127134010254	ADP/pyrophosphate binding site [chemical binding]; other site
1127134010255	fructose-1,6-bisphosphate binding site; other site
1127134010256	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1127134010257	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134010258	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134010259	active site
1127134010260	ATP binding site [chemical binding]; other site
1127134010261	substrate binding site [chemical binding]; other site
1127134010262	activation loop (A-loop); other site
1127134010263	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134010264	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134010265	active site
1127134010266	phosphorylation site [posttranslational modification]
1127134010267	intermolecular recognition site; other site
1127134010268	dimerization interface [polypeptide binding]; other site
1127134010269	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134010270	DNA binding residues [nucleotide binding]
1127134010271	dimerization interface [polypeptide binding]; other site
1127134010272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134010273	Histidine kinase; Region: HisKA_3; pfam07730
1127134010274	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1127134010275	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1127134010276	Walker A/P-loop; other site
1127134010277	ATP binding site [chemical binding]; other site
1127134010278	Q-loop/lid; other site
1127134010279	ABC transporter signature motif; other site
1127134010280	Walker B; other site
1127134010281	D-loop; other site
1127134010282	H-loop/switch region; other site
1127134010283	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1127134010284	FtsX-like permease family; Region: FtsX; pfam02687
1127134010285	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1127134010286	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1127134010287	FtsX-like permease family; Region: FtsX; pfam02687
1127134010288	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134010289	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134010290	active site
1127134010291	ATP binding site [chemical binding]; other site
1127134010292	substrate binding site [chemical binding]; other site
1127134010293	activation loop (A-loop); other site
1127134010294	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134010295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134010296	active site
1127134010297	phosphorylation site [posttranslational modification]
1127134010298	intermolecular recognition site; other site
1127134010299	dimerization interface [polypeptide binding]; other site
1127134010300	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134010301	dimerization interface [polypeptide binding]; other site
1127134010302	DNA binding residues [nucleotide binding]
1127134010303	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1127134010304	Histidine kinase; Region: HisKA_3; pfam07730
1127134010305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134010306	ATP binding site [chemical binding]; other site
1127134010307	Mg2+ binding site [ion binding]; other site
1127134010308	Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056
1127134010309	Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081
1127134010310	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
1127134010311	putative hydrophobic ligand binding site [chemical binding]; other site
1127134010312	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1127134010313	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1127134010314	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1127134010315	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1127134010316	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134010317	Coenzyme A binding pocket [chemical binding]; other site
1127134010318	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134010319	AAA domain; Region: AAA_21; pfam13304
1127134010320	Walker A/P-loop; other site
1127134010321	ATP binding site [chemical binding]; other site
1127134010322	AAA domain; Region: AAA_21; pfam13304
1127134010323	hypothetical protein; Validated; Region: PRK07121
1127134010324	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1127134010325	molybdopterin cofactor binding site; other site
1127134010326	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134010327	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134010328	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134010329	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1127134010330	active site
1127134010331	catalytic residues [active]
1127134010332	metal binding site [ion binding]; metal-binding site
1127134010333	H+ Antiporter protein; Region: 2A0121; TIGR00900
1127134010334	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1127134010335	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1127134010336	nucleotide binding pocket [chemical binding]; other site
1127134010337	K-X-D-G motif; other site
1127134010338	catalytic site [active]
1127134010339	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1127134010340	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1127134010341	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1127134010342	Dimer interface [polypeptide binding]; other site
1127134010343	BRCT sequence motif; other site
1127134010344	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
1127134010345	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1127134010346	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1127134010347	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1127134010348	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1127134010349	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134010350	catalytic residue [active]
1127134010351	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1127134010352	active site
1127134010353	DNA binding site [nucleotide binding]
1127134010354	Int/Topo IB signature motif; other site
1127134010355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1127134010356	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1127134010357	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134010358	Helix-turn-helix domain; Region: HTH_31; pfam13560
1127134010359	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
1127134010360	nudix motif; other site
1127134010361	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134010362	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134010363	catalytic residue [active]
1127134010364	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1127134010365	extended (e) SDRs; Region: SDR_e; cd08946
1127134010366	NAD(P) binding site [chemical binding]; other site
1127134010367	active site
1127134010368	substrate binding site [chemical binding]; other site
1127134010369	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1127134010370	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134010371	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010372	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010373	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1127134010374	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1127134010375	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1127134010376	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134010377	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1127134010378	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1127134010379	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1127134010380	metal-binding site [ion binding]
1127134010381	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1127134010382	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1127134010383	active site residue [active]
1127134010384	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010385	H+ Antiporter protein; Region: 2A0121; TIGR00900
1127134010386	putative substrate translocation pore; other site
1127134010387	multidrug resistance protein MdtH; Provisional; Region: PRK11646
1127134010388	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010389	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1127134010390	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1127134010391	dimer interface [polypeptide binding]; other site
1127134010392	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134010393	catalytic residue [active]
1127134010394	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1127134010395	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1127134010396	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1127134010397	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010398	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010399	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1127134010400	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
1127134010401	active site
1127134010402	FMN binding site [chemical binding]; other site
1127134010403	substrate binding site [chemical binding]; other site
1127134010404	putative catalytic residue [active]
1127134010405	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1127134010406	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134010407	putative acyl-acceptor binding pocket; other site
1127134010408	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1127134010409	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1127134010410	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134010411	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134010412	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134010413	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134010414	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1127134010415	dimerization interface [polypeptide binding]; other site
1127134010416	Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810
1127134010417	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134010418	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134010419	active site
1127134010420	ATP binding site [chemical binding]; other site
1127134010421	substrate binding site [chemical binding]; other site
1127134010422	activation loop (A-loop); other site
1127134010423	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1127134010424	putative active site [active]
1127134010425	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1127134010426	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1127134010427	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1127134010428	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1127134010429	Ligand binding site [chemical binding]; other site
1127134010430	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1127134010431	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134010432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134010433	S-adenosylmethionine binding site [chemical binding]; other site
1127134010434	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1127134010435	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1127134010436	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1127134010437	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1127134010438	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1127134010439	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1127134010440	Trp docking motif [polypeptide binding]; other site
1127134010441	active site
1127134010442	PQQ-like domain; Region: PQQ_2; pfam13360
1127134010443	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1127134010444	Trp docking motif [polypeptide binding]; other site
1127134010445	active site
1127134010446	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1127134010447	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1127134010448	trimer interface [polypeptide binding]; other site
1127134010449	active site
1127134010450	substrate binding site [chemical binding]; other site
1127134010451	CoA binding site [chemical binding]; other site
1127134010452	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1127134010453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134010454	S-adenosylmethionine binding site [chemical binding]; other site
1127134010455	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134010456	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134010457	substrate binding site [chemical binding]; other site
1127134010458	oxyanion hole (OAH) forming residues; other site
1127134010459	trimer interface [polypeptide binding]; other site
1127134010460	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1127134010461	nudix motif; other site
1127134010462	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
1127134010463	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134010464	Walker A/P-loop; other site
1127134010465	ATP binding site [chemical binding]; other site
1127134010466	Q-loop/lid; other site
1127134010467	ABC transporter signature motif; other site
1127134010468	Walker B; other site
1127134010469	D-loop; other site
1127134010470	H-loop/switch region; other site
1127134010471	Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869
1127134010472	dimer interface [polypeptide binding]; other site
1127134010473	putative active site [active]
1127134010474	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
1127134010475	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1127134010476	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1127134010477	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1127134010478	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134010479	motif II; other site
1127134010480	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1127134010481	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1127134010482	D-pathway; other site
1127134010483	Putative ubiquinol binding site [chemical binding]; other site
1127134010484	Low-spin heme (heme b) binding site [chemical binding]; other site
1127134010485	Putative water exit pathway; other site
1127134010486	Binuclear center (heme o3/CuB) [ion binding]; other site
1127134010487	K-pathway; other site
1127134010488	Putative proton exit pathway; other site
1127134010489	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1127134010490	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1127134010491	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134010492	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1127134010493	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1127134010494	intersubunit interface [polypeptide binding]; other site
1127134010495	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010496	Condensation domain; Region: Condensation; pfam00668
1127134010497	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134010498	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134010499	acyl-activating enzyme (AAE) consensus motif; other site
1127134010500	AMP binding site [chemical binding]; other site
1127134010501	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134010502	Condensation domain; Region: Condensation; pfam00668
1127134010503	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1127134010504	Condensation domain; Region: Condensation; pfam00668
1127134010505	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134010506	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134010507	acyl-activating enzyme (AAE) consensus motif; other site
1127134010508	AMP binding site [chemical binding]; other site
1127134010509	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134010510	Condensation domain; Region: Condensation; pfam00668
1127134010511	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134010512	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134010513	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134010514	acyl-activating enzyme (AAE) consensus motif; other site
1127134010515	AMP binding site [chemical binding]; other site
1127134010516	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134010517	Condensation domain; Region: Condensation; pfam00668
1127134010518	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1127134010519	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1127134010520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134010521	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134010522	Walker A/P-loop; other site
1127134010523	ATP binding site [chemical binding]; other site
1127134010524	Q-loop/lid; other site
1127134010525	ABC transporter signature motif; other site
1127134010526	Walker B; other site
1127134010527	D-loop; other site
1127134010528	H-loop/switch region; other site
1127134010529	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134010530	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134010531	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134010532	Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to  the...; Region: intradiol_dioxygenase_like; cd03457
1127134010533	putative active site [active]
1127134010534	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1127134010535	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1127134010536	dimer interface [polypeptide binding]; other site
1127134010537	putative radical transfer pathway; other site
1127134010538	diiron center [ion binding]; other site
1127134010539	tyrosyl radical; other site
1127134010540	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1127134010541	MgtE intracellular N domain; Region: MgtE_N; smart00924
1127134010542	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1127134010543	Divalent cation transporter; Region: MgtE; pfam01769
1127134010544	Caspase domain; Region: Peptidase_C14; pfam00656
1127134010545	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134010546	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134010547	type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925
1127134010548	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134010549	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1127134010550	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
1127134010551	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1127134010552	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1127134010553	active site
1127134010554	dimer interface [polypeptide binding]; other site
1127134010555	catalytic residues [active]
1127134010556	effector binding site; other site
1127134010557	R2 peptide binding site; other site
1127134010558	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
1127134010559	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1127134010560	catalytic residues [active]
1127134010561	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134010562	Predicted flavoprotein [General function prediction only]; Region: COG0431
1127134010563	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010564	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010565	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1127134010566	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1127134010567	homodimer interface [polypeptide binding]; other site
1127134010568	NAD binding pocket [chemical binding]; other site
1127134010569	ATP binding pocket [chemical binding]; other site
1127134010570	Mg binding site [ion binding]; other site
1127134010571	active-site loop [active]
1127134010572	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134010573	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134010574	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134010575	DNA binding residues [nucleotide binding]
1127134010576	YCII-related domain; Region: YCII; cl00999
1127134010577	YCII-related domain; Region: YCII; cl00999
1127134010578	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1127134010579	MoaE interaction surface [polypeptide binding]; other site
1127134010580	MoeB interaction surface [polypeptide binding]; other site
1127134010581	thiocarboxylated glycine; other site
1127134010582	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1127134010583	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134010584	FeS/SAM binding site; other site
1127134010585	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1127134010586	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1127134010587	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1127134010588	dimer interface [polypeptide binding]; other site
1127134010589	putative functional site; other site
1127134010590	putative MPT binding site; other site
1127134010591	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
1127134010592	molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364
1127134010593	trimer interface [polypeptide binding]; other site
1127134010594	dimer interface [polypeptide binding]; other site
1127134010595	putative active site [active]
1127134010596	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1127134010597	MPT binding site; other site
1127134010598	trimer interface [polypeptide binding]; other site
1127134010599	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1127134010600	MoaE homodimer interface [polypeptide binding]; other site
1127134010601	MoaD interaction [polypeptide binding]; other site
1127134010602	active site residues [active]
1127134010603	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134010604	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134010605	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1127134010606	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1127134010607	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1127134010608	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1127134010609	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1127134010610	active site
1127134010611	metal binding site [ion binding]; metal-binding site
1127134010612	RNA polymerase sigma factor SigL; Provisional; Region: PRK09645
1127134010613	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134010614	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134010615	DNA binding residues [nucleotide binding]
1127134010616	short chain dehydrogenase; Provisional; Region: PRK08251
1127134010617	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134010618	NAD(P) binding site [chemical binding]; other site
1127134010619	active site
1127134010620	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134010621	CoenzymeA binding site [chemical binding]; other site
1127134010622	subunit interaction site [polypeptide binding]; other site
1127134010623	PHB binding site; other site
1127134010624	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1127134010625	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134010626	CoenzymeA binding site [chemical binding]; other site
1127134010627	subunit interaction site [polypeptide binding]; other site
1127134010628	PHB binding site; other site
1127134010629	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1127134010630	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010631	metabolite-proton symporter; Region: 2A0106; TIGR00883
1127134010632	putative substrate translocation pore; other site
1127134010633	bile acid transporter; Region: bass; TIGR00841
1127134010634	Sodium Bile acid symporter family; Region: SBF; cl17470
1127134010635	Condensation domain; Region: Condensation; pfam00668
1127134010636	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134010637	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134010638	acyl-activating enzyme (AAE) consensus motif; other site
1127134010639	AMP binding site [chemical binding]; other site
1127134010640	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134010641	Condensation domain; Region: Condensation; pfam00668
1127134010642	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134010643	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134010644	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134010645	thioester reductase domain; Region: Thioester-redct; TIGR01746
1127134010646	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1127134010647	putative NAD(P) binding site [chemical binding]; other site
1127134010648	active site
1127134010649	putative substrate binding site [chemical binding]; other site
1127134010650	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1127134010651	Moco binding site; other site
1127134010652	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1127134010653	metal coordination site [ion binding]; other site
1127134010654	dimerization interface [polypeptide binding]; other site
1127134010655	LexA repressor; Validated; Region: PRK00215
1127134010656	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1127134010657	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1127134010658	Catalytic site [active]
1127134010659	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134010660	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134010661	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1127134010662	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1127134010663	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010664	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010665	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812
1127134010666	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1127134010667	homodimer interface [polypeptide binding]; other site
1127134010668	substrate-cofactor binding pocket; other site
1127134010669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134010670	catalytic residue [active]
1127134010671	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1127134010672	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1127134010673	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1127134010674	spermidine synthase; Provisional; Region: PRK03612
1127134010675	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134010676	Putative esterase; Region: Esterase; pfam00756
1127134010677	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1127134010678	hypothetical protein; Validated; Region: PRK00068
1127134010679	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1127134010680	Isochorismatase family; Region: Isochorismatase; pfam00857
1127134010681	catalytic triad [active]
1127134010682	conserved cis-peptide bond; other site
1127134010683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134010684	NAD(P) binding site [chemical binding]; other site
1127134010685	active site
1127134010686	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134010687	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1127134010688	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1127134010689	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1127134010690	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1127134010691	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1127134010692	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134010693	NAD(P) binding site [chemical binding]; other site
1127134010694	active site
1127134010695	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134010696	active site 2 [active]
1127134010697	active site 1 [active]
1127134010698	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1127134010699	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1127134010700	dimer interface [polypeptide binding]; other site
1127134010701	active site
1127134010702	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134010703	active site 2 [active]
1127134010704	active site 1 [active]
1127134010705	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1127134010706	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1127134010707	dimer interface [polypeptide binding]; other site
1127134010708	active site
1127134010709	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1127134010710	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1127134010711	dimer interface [polypeptide binding]; other site
1127134010712	active site
1127134010713	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1127134010714	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134010715	active site
1127134010716	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1127134010717	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134010718	active site
1127134010719	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1127134010720	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1127134010721	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1127134010722	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1127134010723	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
1127134010724	Predicted esterase [General function prediction only]; Region: COG0627
1127134010725	S-formylglutathione hydrolase; Region: PLN02442
1127134010726	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
1127134010727	DNA binding residues [nucleotide binding]
1127134010728	dimerization interface [polypeptide binding]; other site
1127134010729	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
1127134010730	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010731	putative substrate translocation pore; other site
1127134010732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226
1127134010733	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010734	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134010735	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134010736	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134010737	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1127134010738	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1127134010739	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1127134010740	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134010741	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134010742	non-specific DNA binding site [nucleotide binding]; other site
1127134010743	salt bridge; other site
1127134010744	sequence-specific DNA binding site [nucleotide binding]; other site
1127134010745	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134010746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134010747	non-specific DNA binding site [nucleotide binding]; other site
1127134010748	salt bridge; other site
1127134010749	sequence-specific DNA binding site [nucleotide binding]; other site
1127134010750	Domain of unknown function (DUF955); Region: DUF955; cl01076
1127134010751	haloalkane dehalogenase; Provisional; Region: PRK03592
1127134010752	RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984
1127134010753	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134010754	RibD C-terminal domain; Region: RibD_C; cl17279
1127134010755	multicopper oxidase; Provisional; Region: PRK10965
1127134010756	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1127134010757	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1127134010758	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1127134010759	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
1127134010760	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134010761	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134010762	active site
1127134010763	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134010764	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134010765	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134010766	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1127134010767	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010768	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010769	Phosphotransferase enzyme family; Region: APH; pfam01636
1127134010770	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1127134010771	substrate binding site [chemical binding]; other site
1127134010772	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1127134010773	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1127134010774	putative di-iron ligands [ion binding]; other site
1127134010775	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
1127134010776	Protein of unknown function, DUF488; Region: DUF488; pfam04343
1127134010777	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1127134010778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134010779	motif II; other site
1127134010780	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134010781	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
1127134010782	catalytic residues [active]
1127134010783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010784	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134010785	putative substrate translocation pore; other site
1127134010786	phosphoglucomutase; Validated; Region: PRK07564
1127134010787	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1127134010788	active site
1127134010789	substrate binding site [chemical binding]; other site
1127134010790	metal binding site [ion binding]; metal-binding site
1127134010791	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1127134010792	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1127134010793	Secretory lipase; Region: LIP; pfam03583
1127134010794	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1127134010795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010796	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010797	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010798	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
1127134010799	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134010800	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
1127134010801	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1127134010802	NAD-dependent deacetylase; Provisional; Region: PRK00481
1127134010803	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1127134010804	NAD+ binding site [chemical binding]; other site
1127134010805	substrate binding site [chemical binding]; other site
1127134010806	Zn binding site [ion binding]; other site
1127134010807	Asp23 family; Region: Asp23; pfam03780
1127134010808	Asp23 family; Region: Asp23; pfam03780
1127134010809	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1127134010810	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134010811	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134010812	DNA binding residues [nucleotide binding]
1127134010813	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1127134010814	Secretory lipase; Region: LIP; pfam03583
1127134010815	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1127134010816	Predicted membrane protein (DUF2231); Region: DUF2231; pfam09990
1127134010817	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1127134010818	SmpB-tmRNA interface; other site
1127134010819	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134010820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010821	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010822	MarR family; Region: MarR_2; pfam12802
1127134010823	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
1127134010824	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1127134010825	active site
1127134010826	metal binding site [ion binding]; metal-binding site
1127134010827	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1127134010828	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134010829	ATP binding site [chemical binding]; other site
1127134010830	putative Mg++ binding site [ion binding]; other site
1127134010831	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134010832	nucleotide binding region [chemical binding]; other site
1127134010833	ATP-binding site [chemical binding]; other site
1127134010834	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1127134010835	HRDC domain; Region: HRDC; pfam00570
1127134010836	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1127134010837	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134010838	Coenzyme A binding pocket [chemical binding]; other site
1127134010839	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1127134010840	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1127134010841	active site
1127134010842	Predicted flavoprotein [General function prediction only]; Region: COG0431
1127134010843	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134010844	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1127134010845	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1127134010846	RF-1 domain; Region: RF-1; pfam00472
1127134010847	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1127134010848	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1127134010849	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1127134010850	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134010851	Walker A/P-loop; other site
1127134010852	ATP binding site [chemical binding]; other site
1127134010853	Q-loop/lid; other site
1127134010854	ABC transporter signature motif; other site
1127134010855	Walker B; other site
1127134010856	D-loop; other site
1127134010857	H-loop/switch region; other site
1127134010858	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1127134010859	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1127134010860	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134010861	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134010862	active site
1127134010863	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134010864	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134010865	active site
1127134010866	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1127134010867	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134010868	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134010869	DNA binding residues [nucleotide binding]
1127134010870	MarR family; Region: MarR_2; pfam12802
1127134010871	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134010872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010873	putative substrate translocation pore; other site
1127134010874	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1127134010875	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1127134010876	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134010877	putative DNA binding site [nucleotide binding]; other site
1127134010878	putative Zn2+ binding site [ion binding]; other site
1127134010879	AsnC family; Region: AsnC_trans_reg; pfam01037
1127134010880	AzlC protein; Region: AzlC; pfam03591
1127134010881	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1127134010882	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1127134010883	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1127134010884	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1127134010885	catalytic residues [active]
1127134010886	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1127134010887	Glutaminase; Region: Glutaminase; cl00907
1127134010888	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1127134010889	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010890	putative substrate translocation pore; other site
1127134010891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134010892	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1127134010893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134010894	S-adenosylmethionine binding site [chemical binding]; other site
1127134010895	TIGR02594 family protein; Region: TIGR02594
1127134010896	acyl-CoA synthetase; Validated; Region: PRK07788
1127134010897	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010898	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010899	acyl-activating enzyme (AAE) consensus motif; other site
1127134010900	AMP binding site [chemical binding]; other site
1127134010901	active site
1127134010902	CoA binding site [chemical binding]; other site
1127134010903	acyl-CoA synthetase; Validated; Region: PRK07788
1127134010904	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010905	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010906	acyl-activating enzyme (AAE) consensus motif; other site
1127134010907	AMP binding site [chemical binding]; other site
1127134010908	active site
1127134010909	CoA binding site [chemical binding]; other site
1127134010910	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1127134010911	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1127134010912	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1127134010913	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1127134010914	galactokinase; Provisional; Region: PRK03817
1127134010915	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1127134010916	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
1127134010917	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1127134010918	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1127134010919	metal binding site [ion binding]; metal-binding site
1127134010920	active site
1127134010921	I-site; other site
1127134010922	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1127134010923	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010924	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134010925	acyl-activating enzyme (AAE) consensus motif; other site
1127134010926	acyl-activating enzyme (AAE) consensus motif; other site
1127134010927	AMP binding site [chemical binding]; other site
1127134010928	active site
1127134010929	CoA binding site [chemical binding]; other site
1127134010930	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1127134010931	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
1127134010932	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1127134010933	PQQ-like domain; Region: PQQ_2; pfam13360
1127134010934	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1127134010935	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1127134010936	intersubunit interface [polypeptide binding]; other site
1127134010937	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1127134010938	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1127134010939	ABC-ATPase subunit  interface; other site
1127134010940	dimer interface [polypeptide binding]; other site
1127134010941	putative PBP binding regions; other site
1127134010942	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1127134010943	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134010944	Walker A/P-loop; other site
1127134010945	ATP binding site [chemical binding]; other site
1127134010946	Q-loop/lid; other site
1127134010947	ABC transporter signature motif; other site
1127134010948	Walker B; other site
1127134010949	D-loop; other site
1127134010950	H-loop/switch region; other site
1127134010951	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1127134010952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134010953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134010954	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1127134010955	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1127134010956	hypothetical protein; Validated; Region: PRK00068
1127134010957	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1127134010958	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1127134010959	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1127134010960	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
1127134010961	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1127134010962	ABC1 family; Region: ABC1; pfam03109
1127134010963	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1127134010964	active site
1127134010965	substrate binding site [chemical binding]; other site
1127134010966	ATP binding site [chemical binding]; other site
1127134010967	Transcription factor WhiB; Region: Whib; pfam02467
1127134010968	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1127134010969	Part of AAA domain; Region: AAA_19; pfam13245
1127134010970	Family description; Region: UvrD_C_2; pfam13538
1127134010971	HRDC domain; Region: HRDC; pfam00570
1127134010972	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1127134010973	catalytic residues [active]
1127134010974	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
1127134010975	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1127134010976	putative NADH binding site [chemical binding]; other site
1127134010977	putative active site [active]
1127134010978	nudix motif; other site
1127134010979	putative metal binding site [ion binding]; other site
1127134010980	Ion channel; Region: Ion_trans_2; pfam07885
1127134010981	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1127134010982	TrkA-N domain; Region: TrkA_N; pfam02254
1127134010983	Predicted membrane protein [Function unknown]; Region: COG4270
1127134010984	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1127134010985	DNA helicase II; Region: uvrD; TIGR01075
1127134010986	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1127134010987	Part of AAA domain; Region: AAA_19; pfam13245
1127134010988	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
1127134010989	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1127134010990	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1127134010991	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134010992	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134010993	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1127134010994	catalytic site [active]
1127134010995	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1127134010996	active site
1127134010997	DNA binding site [nucleotide binding]
1127134010998	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134010999	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1127134011000	active site
1127134011001	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1127134011002	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134011003	active site
1127134011004	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1127134011005	GTP binding site; other site
1127134011006	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1127134011007	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1127134011008	dimer interface [polypeptide binding]; other site
1127134011009	putative functional site; other site
1127134011010	putative MPT binding site; other site
1127134011011	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1127134011012	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1127134011013	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
1127134011014	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
1127134011015	[4Fe-4S] binding site [ion binding]; other site
1127134011016	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134011017	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134011018	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1127134011019	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
1127134011020	molybdopterin cofactor binding site; other site
1127134011021	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
1127134011022	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
1127134011023	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
1127134011024	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134011025	dimerization interface [polypeptide binding]; other site
1127134011026	putative DNA binding site [nucleotide binding]; other site
1127134011027	putative Zn2+ binding site [ion binding]; other site
1127134011028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134011029	putative substrate translocation pore; other site
1127134011030	TfoX N-terminal domain; Region: TfoX_N; cl17592
1127134011031	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1127134011032	dimer interface [polypeptide binding]; other site
1127134011033	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134011034	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1127134011035	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1127134011036	putative active site [active]
1127134011037	putative metal binding site [ion binding]; other site
1127134011038	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1127134011039	putative active site [active]
1127134011040	putative CoA binding site [chemical binding]; other site
1127134011041	nudix motif; other site
1127134011042	metal binding site [ion binding]; metal-binding site
1127134011043	Putative esterase; Region: Esterase; pfam00756
1127134011044	S-formylglutathione hydrolase; Region: PLN02442
1127134011045	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1127134011046	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1127134011047	putative active site [active]
1127134011048	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1127134011049	putative active site [active]
1127134011050	bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239
1127134011051	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1127134011052	active site
1127134011053	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134011054	DNA binding site [nucleotide binding]
1127134011055	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
1127134011056	nitrite reductase subunit NirD; Provisional; Region: PRK14989
1127134011057	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1127134011058	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1127134011059	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1127134011060	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1127134011061	cyanate transporter; Region: CynX; TIGR00896
1127134011062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134011063	putative substrate translocation pore; other site
1127134011064	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1127134011065	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134011066	DNA-binding site [nucleotide binding]; DNA binding site
1127134011067	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1127134011068	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1127134011069	TIGR02569 family protein; Region: TIGR02569_actnb
1127134011070	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
1127134011071	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1127134011072	ATP binding site [chemical binding]; other site
1127134011073	substrate interface [chemical binding]; other site
1127134011074	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1127134011075	active site residue [active]
1127134011076	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
1127134011077	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011078	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011079	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
1127134011080	YceI-like domain; Region: YceI; pfam04264
1127134011081	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like; Region: MiaE_2; pfam13794
1127134011082	Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243
1127134011083	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1127134011084	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1127134011085	ATP binding site [chemical binding]; other site
1127134011086	Mg++ binding site [ion binding]; other site
1127134011087	motif III; other site
1127134011088	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134011089	nucleotide binding region [chemical binding]; other site
1127134011090	ATP-binding site [chemical binding]; other site
1127134011091	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134011092	catalytic core [active]
1127134011093	putative acetyltransferase; Provisional; Region: PRK03624
1127134011094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134011095	Coenzyme A binding pocket [chemical binding]; other site
1127134011096	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1127134011097	Active_site [active]
1127134011098	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1127134011099	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1127134011100	Transcription factor WhiB; Region: Whib; pfam02467
1127134011101	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
1127134011102	PAS domain S-box; Region: sensory_box; TIGR00229
1127134011103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1127134011104	putative active site [active]
1127134011105	heme pocket [chemical binding]; other site
1127134011106	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1127134011107	Histidine kinase; Region: HisKA_2; pfam07568
1127134011108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134011109	ATP binding site [chemical binding]; other site
1127134011110	Mg2+ binding site [ion binding]; other site
1127134011111	G-X-G motif; other site
1127134011112	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134011113	carboxyltransferase (CT) interaction site; other site
1127134011114	biotinylation site [posttranslational modification]; other site
1127134011115	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988
1127134011116	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
1127134011117	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134011118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134011119	DNA binding residues [nucleotide binding]
1127134011120	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1127134011121	putative deacylase active site [active]
1127134011122	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1127134011123	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1127134011124	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
1127134011125	NAD(P) binding site [chemical binding]; other site
1127134011126	catalytic residues [active]
1127134011127	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1127134011128	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1127134011129	hinge; other site
1127134011130	active site
1127134011131	Predicted GTPases [General function prediction only]; Region: COG1162
1127134011132	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1127134011133	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1127134011134	GTP/Mg2+ binding site [chemical binding]; other site
1127134011135	G4 box; other site
1127134011136	G5 box; other site
1127134011137	G1 box; other site
1127134011138	Switch I region; other site
1127134011139	G2 box; other site
1127134011140	G3 box; other site
1127134011141	Switch II region; other site
1127134011142	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1127134011143	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1127134011144	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1127134011145	nucleotide binding region [chemical binding]; other site
1127134011146	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
1127134011147	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
1127134011148	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216
1127134011149	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1127134011150	FAD binding pocket [chemical binding]; other site
1127134011151	FAD binding motif [chemical binding]; other site
1127134011152	phosphate binding motif [ion binding]; other site
1127134011153	beta-alpha-beta structure motif; other site
1127134011154	NAD binding pocket [chemical binding]; other site
1127134011155	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134011156	catalytic loop [active]
1127134011157	iron binding site [ion binding]; other site
1127134011158	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1127134011159	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1127134011160	putative di-iron ligands [ion binding]; other site
1127134011161	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1127134011162	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1127134011163	putative di-iron ligands [ion binding]; other site
1127134011164	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1127134011165	putative FMN binding site [chemical binding]; other site
1127134011166	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
1127134011167	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134011168	dimer interface [polypeptide binding]; other site
1127134011169	active site
1127134011170	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1127134011171	30S subunit binding site; other site
1127134011172	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1127134011173	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134011174	active site
1127134011175	lipoprotein LpqB; Provisional; Region: PRK13616
1127134011176	Sporulation and spore germination; Region: Germane; pfam10646
1127134011177	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1127134011178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134011179	dimerization interface [polypeptide binding]; other site
1127134011180	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134011181	dimer interface [polypeptide binding]; other site
1127134011182	phosphorylation site [posttranslational modification]
1127134011183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134011184	ATP binding site [chemical binding]; other site
1127134011185	Mg2+ binding site [ion binding]; other site
1127134011186	G-X-G motif; other site
1127134011187	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134011188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134011189	active site
1127134011190	phosphorylation site [posttranslational modification]
1127134011191	intermolecular recognition site; other site
1127134011192	dimerization interface [polypeptide binding]; other site
1127134011193	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134011194	DNA binding site [nucleotide binding]
1127134011195	thymidylate kinase; Validated; Region: PRK07933
1127134011196	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1127134011197	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1127134011198	homotetramer interface [polypeptide binding]; other site
1127134011199	ligand binding site [chemical binding]; other site
1127134011200	catalytic site [active]
1127134011201	NAD binding site [chemical binding]; other site
1127134011202	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1127134011203	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1127134011204	Di-iron ligands [ion binding]; other site
1127134011205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011207	Rubredoxin [Energy production and conversion]; Region: COG1773
1127134011208	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1127134011209	iron binding site [ion binding]; other site
1127134011210	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1127134011211	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1127134011212	Di-iron ligands [ion binding]; other site
1127134011213	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
1127134011214	nudix motif; other site
1127134011215	F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294
1127134011216	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
1127134011217	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
1127134011218	putative FMN binding site [chemical binding]; other site
1127134011219	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425
1127134011220	phosphate binding site [ion binding]; other site
1127134011221	Transcription factor WhiB; Region: Whib; pfam02467
1127134011222	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
1127134011223	Protein of unknown function (DUF3499); Region: DUF3499; pfam12005
1127134011224	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1127134011225	phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542
1127134011226	active site
1127134011227	substrate binding site [chemical binding]; other site
1127134011228	metal binding site [ion binding]; metal-binding site
1127134011229	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
1127134011230	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1127134011231	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1127134011232	Cation efflux family; Region: Cation_efflux; pfam01545
1127134011233	Htaa; Region: HtaA; pfam04213
1127134011234	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1127134011235	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134011236	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1127134011237	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1127134011238	active site
1127134011239	Substrate binding site; other site
1127134011240	Mg++ binding site; other site
1127134011241	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1127134011242	putative trimer interface [polypeptide binding]; other site
1127134011243	putative CoA binding site [chemical binding]; other site
1127134011244	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1127134011245	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1127134011246	Probable Catalytic site; other site
1127134011247	metal-binding site
1127134011248	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1127134011249	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1127134011250	NADP binding site [chemical binding]; other site
1127134011251	active site
1127134011252	putative substrate binding site [chemical binding]; other site
1127134011253	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1127134011254	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1127134011255	TIGR03089 family protein; Region: TIGR03089
1127134011256	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011257	Cytochrome P450; Region: p450; cl12078
1127134011258	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1127134011259	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134011260	substrate binding pocket [chemical binding]; other site
1127134011261	catalytic triad [active]
1127134011262	Rdx family; Region: Rdx; cl01407
1127134011263	hypothetical protein; Provisional; Region: PRK04233
1127134011264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011265	ABC transporter signature motif; other site
1127134011266	Walker B; other site
1127134011267	D-loop; other site
1127134011268	H-loop/switch region; other site
1127134011269	MoxR-like ATPases [General function prediction only]; Region: COG0714
1127134011270	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1127134011271	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1127134011272	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
1127134011273	metal ion-dependent adhesion site (MIDAS); other site
1127134011274	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1127134011275	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1127134011276	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1127134011277	FtsX-like permease family; Region: FtsX; pfam02687
1127134011278	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1127134011279	FtsX-like permease family; Region: FtsX; pfam02687
1127134011280	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1127134011281	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1127134011282	Walker A/P-loop; other site
1127134011283	ATP binding site [chemical binding]; other site
1127134011284	Q-loop/lid; other site
1127134011285	ABC transporter signature motif; other site
1127134011286	Walker B; other site
1127134011287	D-loop; other site
1127134011288	H-loop/switch region; other site
1127134011289	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134011290	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134011291	active site
1127134011292	ATP binding site [chemical binding]; other site
1127134011293	substrate binding site [chemical binding]; other site
1127134011294	activation loop (A-loop); other site
1127134011295	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134011296	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134011297	active site
1127134011298	ATP binding site [chemical binding]; other site
1127134011299	substrate binding site [chemical binding]; other site
1127134011300	activation loop (A-loop); other site
1127134011301	endonuclease IV; Provisional; Region: PRK01060
1127134011302	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1127134011303	AP (apurinic/apyrimidinic) site pocket; other site
1127134011304	DNA interaction; other site
1127134011305	Metal-binding active site; metal-binding site
1127134011306	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1127134011307	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1127134011308	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1127134011309	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1127134011310	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1127134011311	active site
1127134011312	catalytic residues [active]
1127134011313	metal binding site [ion binding]; metal-binding site
1127134011314	mce related protein; Region: MCE; pfam02470
1127134011315	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134011316	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011317	Cytochrome P450; Region: p450; cl12078
1127134011318	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1127134011319	catalytic residues [active]
1127134011320	dimer interface [polypeptide binding]; other site
1127134011321	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011322	Cytochrome P450; Region: p450; cl12078
1127134011323	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1127134011324	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1127134011325	short chain dehydrogenase; Provisional; Region: PRK07775
1127134011326	classical (c) SDRs; Region: SDR_c; cd05233
1127134011327	NAD(P) binding site [chemical binding]; other site
1127134011328	active site
1127134011329	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011330	Cytochrome P450; Region: p450; cl12078
1127134011331	aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284
1127134011332	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089
1127134011333	NAD binding site [chemical binding]; other site
1127134011334	catalytic residues [active]
1127134011335	short chain dehydrogenase; Provisional; Region: PRK07774
1127134011336	classical (c) SDRs; Region: SDR_c; cd05233
1127134011337	NAD(P) binding site [chemical binding]; other site
1127134011338	active site
1127134011339	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1127134011340	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134011341	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1127134011342	hypothetical protein; Validated; Region: PRK07121
1127134011343	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134011344	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1127134011345	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011346	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1127134011347	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1127134011348	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
1127134011349	putative [Fe4-S4] binding site [ion binding]; other site
1127134011350	putative molybdopterin cofactor binding site [chemical binding]; other site
1127134011351	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1127134011352	putative molybdopterin cofactor binding site; other site
1127134011353	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011354	Cytochrome P450; Region: p450; cl12078
1127134011355	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011356	Cytochrome P450; Region: p450; cl12078
1127134011357	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134011358	S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451
1127134011359	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1127134011360	NAD binding site [chemical binding]; other site
1127134011361	catalytic Zn binding site [ion binding]; other site
1127134011362	substrate binding site [chemical binding]; other site
1127134011363	structural Zn binding site [ion binding]; other site
1127134011364	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134011365	Cytochrome P450; Region: p450; cl12078
1127134011366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011368	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134011369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011370	Walker A/P-loop; other site
1127134011371	ATP binding site [chemical binding]; other site
1127134011372	Q-loop/lid; other site
1127134011373	ABC transporter signature motif; other site
1127134011374	Walker B; other site
1127134011375	D-loop; other site
1127134011376	H-loop/switch region; other site
1127134011377	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134011378	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134011379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011380	Walker A/P-loop; other site
1127134011381	ATP binding site [chemical binding]; other site
1127134011382	Q-loop/lid; other site
1127134011383	ABC transporter signature motif; other site
1127134011384	Walker B; other site
1127134011385	D-loop; other site
1127134011386	H-loop/switch region; other site
1127134011387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011389	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1127134011390	Coenzyme A binding pocket [chemical binding]; other site
1127134011391	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134011392	trimer interface [polypeptide binding]; other site
1127134011393	oxyanion hole (OAH) forming residues; other site
1127134011394	PaaX-like protein; Region: PaaX; pfam07848
1127134011395	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1127134011396	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1127134011397	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1127134011398	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134011399	active site
1127134011400	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1127134011401	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1127134011402	active site
1127134011403	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1127134011404	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134011405	active site
1127134011406	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1127134011407	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134011408	HTH domain; Region: HTH_11; pfam08279
1127134011409	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134011410	WYL domain; Region: WYL; pfam13280
1127134011411	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134011412	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134011413	EspG family; Region: ESX-1_EspG; pfam14011
1127134011414	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134011415	active site
1127134011416	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1127134011417	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
1127134011418	putative active site [active]
1127134011419	catalytic triad [active]
1127134011420	putative dimer interface [polypeptide binding]; other site
1127134011421	ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634
1127134011422	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1127134011423	ATP binding site [chemical binding]; other site
1127134011424	Mg++ binding site [ion binding]; other site
1127134011425	motif III; other site
1127134011426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134011427	nucleotide binding region [chemical binding]; other site
1127134011428	ATP-binding site [chemical binding]; other site
1127134011429	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
1127134011430	putative RNA binding site [nucleotide binding]; other site
1127134011431	Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251
1127134011432	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1127134011433	Part of AAA domain; Region: AAA_19; pfam13245
1127134011434	AAA domain; Region: AAA_12; pfam13087
1127134011435	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813
1127134011436	active site
1127134011437	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134011438	dimer interface [polypeptide binding]; other site
1127134011439	substrate binding site [chemical binding]; other site
1127134011440	catalytic residue [active]
1127134011441	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1127134011442	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1127134011443	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134011444	AMP-binding enzyme; Region: AMP-binding; pfam00501
1127134011445	acyl-activating enzyme (AAE) consensus motif; other site
1127134011446	active site
1127134011447	AMP binding site [chemical binding]; other site
1127134011448	CoA binding site [chemical binding]; other site
1127134011449	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1127134011450	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134011451	substrate binding site [chemical binding]; other site
1127134011452	oxyanion hole (OAH) forming residues; other site
1127134011453	trimer interface [polypeptide binding]; other site
1127134011454	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1127134011455	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1127134011456	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1127134011457	putative dimer interface [polypeptide binding]; other site
1127134011458	N-terminal domain interface [polypeptide binding]; other site
1127134011459	putative substrate binding pocket (H-site) [chemical binding]; other site
1127134011460	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134011461	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011462	Walker A/P-loop; other site
1127134011463	ATP binding site [chemical binding]; other site
1127134011464	Q-loop/lid; other site
1127134011465	ABC transporter signature motif; other site
1127134011466	Walker B; other site
1127134011467	D-loop; other site
1127134011468	H-loop/switch region; other site
1127134011469	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134011470	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134011471	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1127134011472	Walker A/P-loop; other site
1127134011473	ATP binding site [chemical binding]; other site
1127134011474	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1127134011475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011476	Q-loop/lid; other site
1127134011477	ABC transporter signature motif; other site
1127134011478	Walker B; other site
1127134011479	D-loop; other site
1127134011480	H-loop/switch region; other site
1127134011481	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134011482	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011483	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1127134011484	Walker A/P-loop; other site
1127134011485	ATP binding site [chemical binding]; other site
1127134011486	Q-loop/lid; other site
1127134011487	ABC transporter signature motif; other site
1127134011488	Walker B; other site
1127134011489	D-loop; other site
1127134011490	H-loop/switch region; other site
1127134011491	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
1127134011492	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1127134011493	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1127134011494	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1127134011495	TPP-binding site [chemical binding]; other site
1127134011496	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1127134011497	probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559
1127134011498	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1127134011499	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011500	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011501	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134011502	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134011503	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134011504	short chain dehydrogenase; Provisional; Region: PRK07832
1127134011505	NAD(P) binding site [chemical binding]; other site
1127134011506	active site
1127134011507	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1127134011508	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
1127134011509	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1127134011510	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1127134011511	acyl-activating enzyme (AAE) consensus motif; other site
1127134011512	putative AMP binding site [chemical binding]; other site
1127134011513	putative active site [active]
1127134011514	putative CoA binding site [chemical binding]; other site
1127134011515	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134011516	putative substrate translocation pore; other site
1127134011517	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134011518	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134011519	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1127134011520	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1127134011521	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1127134011522	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
1127134011523	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1127134011524	Walker A/P-loop; other site
1127134011525	ATP binding site [chemical binding]; other site
1127134011526	Q-loop/lid; other site
1127134011527	ABC transporter signature motif; other site
1127134011528	Walker B; other site
1127134011529	D-loop; other site
1127134011530	H-loop/switch region; other site
1127134011531	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1127134011532	ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174
1127134011533	Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830
1127134011534	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1127134011535	oligomer interface [polypeptide binding]; other site
1127134011536	metal binding site [ion binding]; metal-binding site
1127134011537	metal binding site [ion binding]; metal-binding site
1127134011538	putative Cl binding site [ion binding]; other site
1127134011539	basic sphincter; other site
1127134011540	hydrophobic gate; other site
1127134011541	periplasmic entrance; other site
1127134011542	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1127134011543	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
1127134011544	active site
1127134011545	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1127134011546	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
1127134011547	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1127134011548	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1127134011549	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1127134011550	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
1127134011551	NAD(P) binding pocket [chemical binding]; other site
1127134011552	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1127134011553	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1127134011554	PRC-barrel domain; Region: PRC; pfam05239
1127134011555	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1127134011556	MgtE intracellular N domain; Region: MgtE_N; smart00924
1127134011557	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1127134011558	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1127134011559	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134011560	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134011561	catalytic residue [active]
1127134011562	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134011563	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134011564	Domain of unknown function DUF59; Region: DUF59; cl00941
1127134011565	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1127134011566	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1127134011567	DivIVA domain; Region: DivI1A_domain; TIGR03544
1127134011568	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1127134011569	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1127134011570	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1127134011571	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1127134011572	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1127134011573	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
1127134011574	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1127134011575	ligand binding site; other site
1127134011576	oligomer interface; other site
1127134011577	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1127134011578	dimer interface [polypeptide binding]; other site
1127134011579	N-terminal domain interface [polypeptide binding]; other site
1127134011580	sulfate 1 binding site; other site
1127134011581	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
1127134011582	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134011583	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134011584	Walker A/P-loop; other site
1127134011585	ATP binding site [chemical binding]; other site
1127134011586	Q-loop/lid; other site
1127134011587	ABC transporter signature motif; other site
1127134011588	Walker B; other site
1127134011589	D-loop; other site
1127134011590	H-loop/switch region; other site
1127134011591	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1127134011592	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011593	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011594	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1127134011595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134011596	S-adenosylmethionine binding site [chemical binding]; other site
1127134011597	RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647
1127134011598	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134011599	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134011600	DNA binding residues [nucleotide binding]
1127134011601	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1127134011602	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1127134011603	protein binding site [polypeptide binding]; other site
1127134011604	sec-independent translocase; Provisional; Region: PRK03100
1127134011605	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
1127134011606	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1127134011607	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1127134011608	dihydropteroate synthase; Region: DHPS; TIGR01496
1127134011609	substrate binding pocket [chemical binding]; other site
1127134011610	dimer interface [polypeptide binding]; other site
1127134011611	inhibitor binding site; inhibition site
1127134011612	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1127134011613	long-chain-acyl-CoA synthetase; Validated; Region: PRK08279
1127134011614	Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940
1127134011615	acyl-activating enzyme (AAE) consensus motif; other site
1127134011616	putative AMP binding site [chemical binding]; other site
1127134011617	putative active site [active]
1127134011618	putative CoA binding site [chemical binding]; other site
1127134011619	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1127134011620	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1127134011621	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
1127134011622	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
1127134011623	metal binding site [ion binding]; metal-binding site
1127134011624	putative dimer interface [polypeptide binding]; other site
1127134011625	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
1127134011626	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1127134011627	putative trimer interface [polypeptide binding]; other site
1127134011628	putative CoA binding site [chemical binding]; other site
1127134011629	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134011630	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134011631	active site
1127134011632	ATP binding site [chemical binding]; other site
1127134011633	substrate binding site [chemical binding]; other site
1127134011634	activation loop (A-loop); other site
1127134011635	acyl-CoA synthetase; Validated; Region: PRK07787
1127134011636	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134011637	acyl-activating enzyme (AAE) consensus motif; other site
1127134011638	AMP binding site [chemical binding]; other site
1127134011639	active site
1127134011640	CoA binding site [chemical binding]; other site
1127134011641	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1127134011642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011644	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1127134011645	Proline dehydrogenase; Region: Pro_dh; cl03282
1127134011646	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
1127134011647	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134011648	NAD(P) binding site [chemical binding]; other site
1127134011649	catalytic residues [active]
1127134011650	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
1127134011651	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134011652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134011653	homodimer interface [polypeptide binding]; other site
1127134011654	catalytic residue [active]
1127134011655	Ferredoxin [Energy production and conversion]; Region: COG1146
1127134011656	4Fe-4S binding domain; Region: Fer4; pfam00037
1127134011657	FO synthase; Reviewed; Region: fbiC; PRK09234
1127134011658	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134011659	FeS/SAM binding site; other site
1127134011660	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134011661	FeS/SAM binding site; other site
1127134011662	Bacterial PH domain; Region: DUF304; cl01348
1127134011663	Predicted membrane protein [Function unknown]; Region: COG3428
1127134011664	Bacterial PH domain; Region: DUF304; pfam03703
1127134011665	Bacterial PH domain; Region: DUF304; cl01348
1127134011666	N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445
1127134011667	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1127134011668	The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501
1127134011669	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1127134011670	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1127134011671	G1 box; other site
1127134011672	putative GEF interaction site [polypeptide binding]; other site
1127134011673	GTP/Mg2+ binding site [chemical binding]; other site
1127134011674	Switch I region; other site
1127134011675	G2 box; other site
1127134011676	G3 box; other site
1127134011677	Switch II region; other site
1127134011678	G4 box; other site
1127134011679	G5 box; other site
1127134011680	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1127134011681	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1127134011682	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1127134011683	aromatic arch; other site
1127134011684	DCoH dimer interaction site [polypeptide binding]; other site
1127134011685	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1127134011686	DCoH tetramer interaction site [polypeptide binding]; other site
1127134011687	substrate binding site [chemical binding]; other site
1127134011688	mannosyltransferase; Provisional; Region: pimE; PRK13375
1127134011689	Domain of unknown function (DUF1906); Region: DUF1906; pfam08924
1127134011690	Uncharacterized protein conserved in bacteria (DUF2272); Region: DUF2272; cl01776
1127134011691	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134011692	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134011693	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134011694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134011695	putative PBP binding loops; other site
1127134011696	ABC-ATPase subunit interface; other site
1127134011697	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1127134011698	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
1127134011699	Walker A/P-loop; other site
1127134011700	ATP binding site [chemical binding]; other site
1127134011701	Q-loop/lid; other site
1127134011702	ABC transporter signature motif; other site
1127134011703	Walker B; other site
1127134011704	D-loop; other site
1127134011705	H-loop/switch region; other site
1127134011706	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1127134011707	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134011708	ABC-ATPase subunit interface; other site
1127134011709	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1127134011710	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1127134011711	MarR family; Region: MarR_2; pfam12802
1127134011712	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1127134011713	Putative esterase; Region: Esterase; pfam00756
1127134011714	Protein of unknown function (DUF419); Region: DUF419; cl15265
1127134011715	hypothetical protein; Provisional; Region: PRK07758
1127134011716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134011717	Coenzyme A binding pocket [chemical binding]; other site
1127134011718	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1127134011719	DoxX-like family; Region: DoxX_2; pfam13564
1127134011720	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134011721	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134011722	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1127134011723	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134011724	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134011725	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134011726	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1127134011727	oligomeric interface; other site
1127134011728	putative active site [active]
1127134011729	homodimer interface [polypeptide binding]; other site
1127134011730	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134011731	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1127134011732	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
1127134011733	Predicted nucleotidyltransferase [General function prediction    only]; Region: COG4849
1127134011734	GTP-binding protein YchF; Reviewed; Region: PRK09601
1127134011735	YchF GTPase; Region: YchF; cd01900
1127134011736	G1 box; other site
1127134011737	GTP/Mg2+ binding site [chemical binding]; other site
1127134011738	Switch I region; other site
1127134011739	G2 box; other site
1127134011740	Switch II region; other site
1127134011741	G3 box; other site
1127134011742	G4 box; other site
1127134011743	G5 box; other site
1127134011744	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1127134011745	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134011746	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1127134011747	NAD(P) binding site [chemical binding]; other site
1127134011748	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134011749	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134011750	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355
1127134011751	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134011752	Nitroreductase-like family 5.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148
1127134011753	putative FMN binding site [chemical binding]; other site
1127134011754	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1127134011755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134011756	dimer interface [polypeptide binding]; other site
1127134011757	conserved gate region; other site
1127134011758	putative PBP binding loops; other site
1127134011759	ABC-ATPase subunit interface; other site
1127134011760	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1127134011761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134011762	putative PBP binding loops; other site
1127134011763	dimer interface [polypeptide binding]; other site
1127134011764	ABC-ATPase subunit interface; other site
1127134011765	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1127134011766	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1127134011767	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
1127134011768	Carbon starvation protein CstA; Region: CstA; pfam02554
1127134011769	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1127134011770	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1127134011771	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1127134011772	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1127134011773	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134011774	AlkA N-terminal domain; Region: AlkA_N; pfam06029
1127134011775	3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308
1127134011776	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1127134011777	minor groove reading motif; other site
1127134011778	helix-hairpin-helix signature motif; other site
1127134011779	substrate binding pocket [chemical binding]; other site
1127134011780	active site
1127134011781	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1127134011782	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1127134011783	active site
1127134011784	DNA binding site [nucleotide binding]
1127134011785	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1127134011786	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134011787	DNA-binding site [nucleotide binding]; DNA binding site
1127134011788	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134011789	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134011790	homodimer interface [polypeptide binding]; other site
1127134011791	catalytic residue [active]
1127134011792	Cupin domain; Region: Cupin_2; pfam07883
1127134011793	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1127134011794	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011795	Walker A/P-loop; other site
1127134011796	ATP binding site [chemical binding]; other site
1127134011797	Q-loop/lid; other site
1127134011798	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1127134011799	ABC transporter signature motif; other site
1127134011800	Walker B; other site
1127134011801	D-loop; other site
1127134011802	H-loop/switch region; other site
1127134011803	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1127134011804	active site
1127134011805	metal binding site [ion binding]; metal-binding site
1127134011806	DNA binding site [nucleotide binding]
1127134011807	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1127134011808	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1127134011809	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1127134011810	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1127134011811	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1127134011812	generic binding surface II; other site
1127134011813	generic binding surface I; other site
1127134011814	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1127134011815	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238
1127134011816	dimer interface [polypeptide binding]; other site
1127134011817	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134011818	Protein of unknown function (DUF4245); Region: DUF4245; pfam14030
1127134011819	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1127134011820	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1127134011821	putative active site [active]
1127134011822	LGFP repeat; Region: LGFP; pfam08310
1127134011823	LGFP repeat; Region: LGFP; pfam08310
1127134011824	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1127134011825	dinuclear metal binding motif [ion binding]; other site
1127134011826	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1127134011827	Class II fumarases; Region: Fumarase_classII; cd01362
1127134011828	active site
1127134011829	tetramer interface [polypeptide binding]; other site
1127134011830	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1127134011831	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1127134011832	putative active site [active]
1127134011833	PhoH-like protein; Region: PhoH; pfam02562
1127134011834	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1127134011835	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134011836	FMN binding site [chemical binding]; other site
1127134011837	substrate binding site [chemical binding]; other site
1127134011838	putative catalytic residue [active]
1127134011839	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1127134011840	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134011841	active site
1127134011842	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134011843	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134011844	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687
1127134011845	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1127134011846	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1127134011847	FMN-binding pocket [chemical binding]; other site
1127134011848	flavin binding motif; other site
1127134011849	phosphate binding motif [ion binding]; other site
1127134011850	beta-alpha-beta structure motif; other site
1127134011851	NAD binding pocket [chemical binding]; other site
1127134011852	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134011853	catalytic loop [active]
1127134011854	iron binding site [ion binding]; other site
1127134011855	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011856	Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941
1127134011857	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134011858	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1127134011859	YCII-related domain; Region: YCII; cl00999
1127134011860	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1127134011861	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011862	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011863	short chain dehydrogenase; Validated; Region: PRK08264
1127134011864	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134011865	NAD(P) binding site [chemical binding]; other site
1127134011866	active site
1127134011867	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1127134011868	Protein of unknown function (DUF779); Region: DUF779; pfam05610
1127134011869	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
1127134011870	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134011871	NAD(P) binding site [chemical binding]; other site
1127134011872	catalytic residues [active]
1127134011873	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1127134011874	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134011875	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1127134011876	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1127134011877	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1127134011878	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1127134011879	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134011880	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134011881	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134011882	hypothetical protein; Provisional; Region: PRK07236
1127134011883	hypothetical protein; Provisional; Region: PRK07588
1127134011884	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1127134011885	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1127134011886	dimer interface [polypeptide binding]; other site
1127134011887	active site
1127134011888	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1127134011889	folate binding site [chemical binding]; other site
1127134011890	pantothenate kinase; Provisional; Region: PRK05439
1127134011891	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1127134011892	ATP-binding site [chemical binding]; other site
1127134011893	CoA-binding site [chemical binding]; other site
1127134011894	Mg2+-binding site [ion binding]; other site
1127134011895	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
1127134011896	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1127134011897	catalytic residue [active]
1127134011898	putative FPP diphosphate  binding site; other site
1127134011899	putative FPP binding hydrophobic cleft; other site
1127134011900	dimer interface [polypeptide binding]; other site
1127134011901	putative IPP diphosphate binding site; other site
1127134011902	Haemolysin-III related; Region: HlyIII; cl03831
1127134011903	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134011904	dimerization interface [polypeptide binding]; other site
1127134011905	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1127134011906	cyclase homology domain; Region: CHD; cd07302
1127134011907	nucleotidyl binding site; other site
1127134011908	metal binding site [ion binding]; metal-binding site
1127134011909	dimer interface [polypeptide binding]; other site
1127134011910	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1127134011911	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1127134011912	putative acyl-acceptor binding pocket; other site
1127134011913	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1127134011914	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
1127134011915	catalytic residues [active]
1127134011916	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134011917	active site
1127134011918	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134011919	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1127134011920	active site
1127134011921	metal binding site [ion binding]; metal-binding site
1127134011922	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134011923	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134011924	DNA binding residues [nucleotide binding]
1127134011925	Predicted ATPase [General function prediction only]; Region: COG3903
1127134011926	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1127134011927	nudix motif; other site
1127134011928	mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446
1127134011929	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
1127134011930	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1127134011931	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1127134011932	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1127134011933	cystathionine gamma-synthase; Provisional; Region: PRK07811
1127134011934	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1127134011935	homodimer interface [polypeptide binding]; other site
1127134011936	substrate-cofactor binding pocket; other site
1127134011937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134011938	catalytic residue [active]
1127134011939	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134011940	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134011941	active site
1127134011942	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134011943	EspG family; Region: ESX-1_EspG; pfam14011
1127134011944	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134011945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134011946	non-specific DNA binding site [nucleotide binding]; other site
1127134011947	salt bridge; other site
1127134011948	sequence-specific DNA binding site [nucleotide binding]; other site
1127134011949	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134011950	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
1127134011951	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1127134011952	dimer interface [polypeptide binding]; other site
1127134011953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134011954	catalytic residue [active]
1127134011955	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
1127134011956	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1127134011957	active site
1127134011958	catalytic triad [active]
1127134011959	oxyanion hole [active]
1127134011960	acetyl-CoA acetyltransferase; Provisional; Region: PRK07851
1127134011961	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134011962	dimer interface [polypeptide binding]; other site
1127134011963	active site
1127134011964	Bax inhibitor 1 like; Region: BaxI_1; cl17691
1127134011965	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
1127134011966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134011967	S-adenosylmethionine binding site [chemical binding]; other site
1127134011968	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1127134011969	Predicted membrane protein [Function unknown]; Region: COG2311
1127134011970	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1127134011971	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134011972	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134011973	active site
1127134011974	amino acid transporter; Region: 2A0306; TIGR00909
1127134011975	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
1127134011976	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1127134011977	POT family; Region: PTR2; cl17359
1127134011978	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1127134011979	hydrophobic ligand binding site; other site
1127134011980	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1127134011981	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1127134011982	Uncharacterized conserved protein [Function unknown]; Region: COG1507
1127134011983	enolase; Provisional; Region: eno; PRK00077
1127134011984	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1127134011985	dimer interface [polypeptide binding]; other site
1127134011986	metal binding site [ion binding]; metal-binding site
1127134011987	substrate binding pocket [chemical binding]; other site
1127134011988	Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951
1127134011989	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134011990	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134011991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134011992	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1127134011993	Walker A/P-loop; other site
1127134011994	ATP binding site [chemical binding]; other site
1127134011995	Q-loop/lid; other site
1127134011996	ABC transporter signature motif; other site
1127134011997	Walker B; other site
1127134011998	D-loop; other site
1127134011999	H-loop/switch region; other site
1127134012000	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1127134012001	Walker A/P-loop; other site
1127134012002	ATP binding site [chemical binding]; other site
1127134012003	Q-loop/lid; other site
1127134012004	ABC transporter signature motif; other site
1127134012005	Walker B; other site
1127134012006	D-loop; other site
1127134012007	H-loop/switch region; other site
1127134012008	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1127134012009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134012010	dimer interface [polypeptide binding]; other site
1127134012011	conserved gate region; other site
1127134012012	putative PBP binding loops; other site
1127134012013	ABC-ATPase subunit interface; other site
1127134012014	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1127134012015	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1127134012016	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1127134012017	substrate binding pocket [chemical binding]; other site
1127134012018	active site
1127134012019	iron coordination sites [ion binding]; other site
1127134012020	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
1127134012021	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1127134012022	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1127134012023	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842
1127134012024	dimer interface [polypeptide binding]; other site
1127134012025	active site
1127134012026	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1127134012027	catalytic residues [active]
1127134012028	substrate binding site [chemical binding]; other site
1127134012029	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1127134012030	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1127134012031	dimer interface [polypeptide binding]; other site
1127134012032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134012033	catalytic residue [active]
1127134012034	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1127134012035	putative efflux protein, MATE family; Region: matE; TIGR00797
1127134012036	cation binding site [ion binding]; other site
1127134012037	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1127134012038	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134012039	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134012040	putative metal binding site [ion binding]; other site
1127134012041	MMPL family; Region: MMPL; pfam03176
1127134012042	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334
1127134012043	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1127134012044	homodimer interface [polypeptide binding]; other site
1127134012045	metal binding site [ion binding]; metal-binding site
1127134012046	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012048	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1127134012049	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1127134012050	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1127134012051	ATP binding site [chemical binding]; other site
1127134012052	putative Mg++ binding site [ion binding]; other site
1127134012053	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134012054	nucleotide binding region [chemical binding]; other site
1127134012055	ATP-binding site [chemical binding]; other site
1127134012056	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1127134012057	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012059	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
1127134012060	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1127134012061	Substrate binding site; other site
1127134012062	Mg++ binding site; other site
1127134012063	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1127134012064	active site
1127134012065	substrate binding site [chemical binding]; other site
1127134012066	CoA binding site [chemical binding]; other site
1127134012067	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1127134012068	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
1127134012069	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134012070	active site
1127134012071	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1127134012072	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
1127134012073	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1127134012074	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
1127134012075	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1127134012076	putative dimer interface [polypeptide binding]; other site
1127134012077	putative active site [active]
1127134012078	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
1127134012079	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1127134012080	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1127134012081	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1127134012082	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134012083	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134012084	catalytic residue [active]
1127134012085	ribonuclease Z; Reviewed; Region: PRK00055
1127134012086	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1127134012087	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1127134012088	acyl-activating enzyme (AAE) consensus motif; other site
1127134012089	active site
1127134012090	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1127134012091	putative active site [active]
1127134012092	catalytic residue [active]
1127134012093	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
1127134012094	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1127134012095	5S rRNA interface [nucleotide binding]; other site
1127134012096	CTC domain interface [polypeptide binding]; other site
1127134012097	L16 interface [polypeptide binding]; other site
1127134012098	Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108
1127134012099	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1127134012100	G1 box; other site
1127134012101	putative GEF interaction site [polypeptide binding]; other site
1127134012102	GTP/Mg2+ binding site [chemical binding]; other site
1127134012103	Switch I region; other site
1127134012104	G2 box; other site
1127134012105	G3 box; other site
1127134012106	Switch II region; other site
1127134012107	G4 box; other site
1127134012108	G5 box; other site
1127134012109	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1127134012110	SnoaL-like domain; Region: SnoaL_4; pfam13577
1127134012111	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
1127134012112	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1127134012113	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
1127134012114	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1127134012115	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134012116	Walker A/P-loop; other site
1127134012117	ATP binding site [chemical binding]; other site
1127134012118	Q-loop/lid; other site
1127134012119	ABC transporter signature motif; other site
1127134012120	Walker B; other site
1127134012121	D-loop; other site
1127134012122	H-loop/switch region; other site
1127134012123	ABC transporter; Region: ABC_tran_2; pfam12848
1127134012124	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1127134012125	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
1127134012126	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1127134012127	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1127134012128	metal-binding site [ion binding]
1127134012129	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1127134012130	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1127134012131	Secretory lipase; Region: LIP; pfam03583
1127134012132	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
1127134012133	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1127134012134	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1127134012135	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1127134012136	G5 domain; Region: G5; pfam07501
1127134012137	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1127134012138	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1127134012139	active site
1127134012140	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1127134012141	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1127134012142	active site
1127134012143	HIGH motif; other site
1127134012144	KMSKS motif; other site
1127134012145	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1127134012146	tRNA binding surface [nucleotide binding]; other site
1127134012147	anticodon binding site; other site
1127134012148	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1127134012149	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
1127134012150	tetramer interface [polypeptide binding]; other site
1127134012151	active site
1127134012152	Mg2+/Mn2+ binding site [ion binding]; other site
1127134012153	Predicted methyltransferases [General function prediction only]; Region: COG0313
1127134012154	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1127134012155	putative SAM binding site [chemical binding]; other site
1127134012156	putative homodimer interface [polypeptide binding]; other site
1127134012157	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1127134012158	Predicted transcriptional regulators [Transcription]; Region: COG1725
1127134012159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134012160	DNA-binding site [nucleotide binding]; DNA binding site
1127134012161	arginine deiminase; Provisional; Region: PRK01388
1127134012162	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1127134012163	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134012164	DNA binding residues [nucleotide binding]
1127134012165	short chain dehydrogenase; Provisional; Region: PRK07832
1127134012166	classical (c) SDRs; Region: SDR_c; cd05233
1127134012167	NAD(P) binding site [chemical binding]; other site
1127134012168	active site
1127134012169	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1127134012170	glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047
1127134012171	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1127134012172	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1127134012173	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1127134012174	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1127134012175	metal binding site [ion binding]; metal-binding site
1127134012176	active site
1127134012177	I-site; other site
1127134012178	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1127134012179	hypothetical protein; Provisional; Region: PRK07877
1127134012180	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
1127134012181	ATP binding site [chemical binding]; other site
1127134012182	substrate interface [chemical binding]; other site
1127134012183	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1127134012184	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1127134012185	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1127134012186	Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031
1127134012187	Fe-S cluster binding site [ion binding]; other site
1127134012188	DNA binding site [nucleotide binding]
1127134012189	active site
1127134012190	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1127134012191	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1127134012192	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1127134012193	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1127134012194	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134012195	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134012196	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134012197	DNA binding residues [nucleotide binding]
1127134012198	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134012199	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134012200	DNA binding residues [nucleotide binding]
1127134012201	dimerization interface [polypeptide binding]; other site
1127134012202	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134012203	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134012204	DNA binding residues [nucleotide binding]
1127134012205	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134012206	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134012207	DNA binding residues [nucleotide binding]
1127134012208	dimerization interface [polypeptide binding]; other site
1127134012209	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1127134012210	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1127134012211	Zn binding site [ion binding]; other site
1127134012212	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134012213	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134012214	DNA binding residues [nucleotide binding]
1127134012215	dimerization interface [polypeptide binding]; other site
1127134012216	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134012217	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1127134012218	putative acyl-acceptor binding pocket; other site
1127134012219	Protein of unknown function (DUF998); Region: DUF998; pfam06197
1127134012220	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1127134012221	putative transposase OrfB; Reviewed; Region: PHA02517
1127134012222	HTH-like domain; Region: HTH_21; pfam13276
1127134012223	Integrase core domain; Region: rve; pfam00665
1127134012224	Integrase core domain; Region: rve_3; pfam13683
1127134012225	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1127134012226	Transposase; Region: HTH_Tnp_1; cl17663
1127134012227	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134012228	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134012229	active site
1127134012230	catalytic tetrad [active]
1127134012231	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1127134012232	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1127134012233	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1127134012234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134012235	S-adenosylmethionine binding site [chemical binding]; other site
1127134012236	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1127134012237	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1127134012238	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1127134012239	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1127134012240	dimer interface [polypeptide binding]; other site
1127134012241	putative functional site; other site
1127134012242	putative MPT binding site; other site
1127134012243	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1127134012244	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1127134012245	active site
1127134012246	tetramer interface; other site
1127134012247	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1127134012248	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
1127134012249	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1127134012250	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1127134012251	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1127134012252	MspA; Region: MspA; pfam09203
1127134012253	MspA; Region: MspA; pfam09203
1127134012254	MspA; Region: MspA; pfam09203
1127134012255	MspA; Region: MspA; pfam09203
1127134012256	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1127134012257	MPT binding site; other site
1127134012258	trimer interface [polypeptide binding]; other site
1127134012259	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1127134012260	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1127134012261	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1127134012262	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134012263	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134012264	dimerization interface [polypeptide binding]; other site
1127134012265	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134012266	dimer interface [polypeptide binding]; other site
1127134012267	phosphorylation site [posttranslational modification]
1127134012268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134012269	ATP binding site [chemical binding]; other site
1127134012270	Mg2+ binding site [ion binding]; other site
1127134012271	G-X-G motif; other site
1127134012272	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134012273	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134012274	active site
1127134012275	phosphorylation site [posttranslational modification]
1127134012276	intermolecular recognition site; other site
1127134012277	dimerization interface [polypeptide binding]; other site
1127134012278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134012279	DNA binding site [nucleotide binding]
1127134012280	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1127134012281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134012282	ATP binding site [chemical binding]; other site
1127134012283	Mg2+ binding site [ion binding]; other site
1127134012284	G-X-G motif; other site
1127134012285	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
1127134012286	Protein of unknown function (DUF742); Region: DUF742; pfam05331
1127134012287	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1127134012288	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1127134012289	G1 box; other site
1127134012290	GTP/Mg2+ binding site [chemical binding]; other site
1127134012291	G2 box; other site
1127134012292	Switch I region; other site
1127134012293	G3 box; other site
1127134012294	Switch II region; other site
1127134012295	G4 box; other site
1127134012296	G5 box; other site
1127134012297	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1127134012298	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1127134012299	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1127134012300	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1127134012301	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1127134012302	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1127134012303	30S ribosomal protein S18; Provisional; Region: PRK13401
1127134012304	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1127134012305	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1127134012306	purine monophosphate binding site [chemical binding]; other site
1127134012307	dimer interface [polypeptide binding]; other site
1127134012308	putative catalytic residues [active]
1127134012309	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1127134012310	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1127134012311	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1127134012312	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1127134012313	active site
1127134012314	substrate binding site [chemical binding]; other site
1127134012315	cosubstrate binding site; other site
1127134012316	catalytic site [active]
1127134012317	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1127134012318	CoA binding domain; Region: CoA_binding; smart00881
1127134012319	CoA-ligase; Region: Ligase_CoA; pfam00549
1127134012320	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1127134012321	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1127134012322	CoA-ligase; Region: Ligase_CoA; pfam00549
1127134012323	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1127134012324	Peptidase family M23; Region: Peptidase_M23; pfam01551
1127134012325	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134012326	hydrophobic ligand binding site; other site
1127134012327	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134012328	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1127134012329	NAD(P) binding site [chemical binding]; other site
1127134012330	active site
1127134012331	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1127134012332	Part of AAA domain; Region: AAA_19; pfam13245
1127134012333	Family description; Region: UvrD_C_2; pfam13538
1127134012334	hypothetical protein; Provisional; Region: PRK07857
1127134012335	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134012336	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1127134012337	tetramerization interface [polypeptide binding]; other site
1127134012338	NAD(P) binding site [chemical binding]; other site
1127134012339	catalytic residues [active]
1127134012340	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1127134012341	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1127134012342	active site
1127134012343	dimer interface [polypeptide binding]; other site
1127134012344	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1127134012345	dimer interface [polypeptide binding]; other site
1127134012346	active site
1127134012347	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1127134012348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134012349	putative substrate translocation pore; other site
1127134012350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012351	isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561
1127134012352	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134012353	active site
1127134012354	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
1127134012355	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1127134012356	active site
1127134012357	Ion channel; Region: Ion_trans_2; pfam07885
1127134012358	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1127134012359	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1127134012360	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134012361	DNA-binding site [nucleotide binding]; DNA binding site
1127134012362	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134012363	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134012364	homodimer interface [polypeptide binding]; other site
1127134012365	catalytic residue [active]
1127134012366	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134012367	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134012368	active site
1127134012369	catalytic tetrad [active]
1127134012370	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012371	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012372	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1127134012373	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1127134012374	putative DNA binding site [nucleotide binding]; other site
1127134012375	catalytic residue [active]
1127134012376	putative H2TH interface [polypeptide binding]; other site
1127134012377	putative catalytic residues [active]
1127134012378	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1127134012379	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1127134012380	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
1127134012381	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134012382	substrate binding pocket [chemical binding]; other site
1127134012383	catalytic triad [active]
1127134012384	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
1127134012385	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134012386	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134012387	DNA binding residues [nucleotide binding]
1127134012388	Anti-sigma-K factor rskA; Region: RskA; pfam10099
1127134012389	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1127134012390	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134012391	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134012392	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1127134012393	Protein of unknown function (DUF2630); Region: DUF2630; pfam10944
1127134012394	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1127134012395	active site
1127134012396	SAM binding site [chemical binding]; other site
1127134012397	homodimer interface [polypeptide binding]; other site
1127134012398	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1127134012399	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1127134012400	dimerization interface [polypeptide binding]; other site
1127134012401	active site
1127134012402	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134012403	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1127134012404	folate binding site [chemical binding]; other site
1127134012405	NADP+ binding site [chemical binding]; other site
1127134012406	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1127134012407	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
1127134012408	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
1127134012409	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134012410	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134012411	putative metal binding site [ion binding]; other site
1127134012412	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
1127134012413	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134012414	putative metal binding site [ion binding]; other site
1127134012415	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1127134012416	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134012417	Predicted transcriptional regulator [Transcription]; Region: COG2378
1127134012418	HTH domain; Region: HTH_11; pfam08279
1127134012419	WYL domain; Region: WYL; pfam13280
1127134012420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012422	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1127134012423	putative catalytic residues [active]
1127134012424	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
1127134012425	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1127134012426	putative active site [active]
1127134012427	Condensation domain; Region: Condensation; pfam00668
1127134012428	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012429	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134012430	acyl-activating enzyme (AAE) consensus motif; other site
1127134012431	AMP binding site [chemical binding]; other site
1127134012432	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012433	Condensation domain; Region: Condensation; pfam00668
1127134012434	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012435	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012436	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012437	acyl-activating enzyme (AAE) consensus motif; other site
1127134012438	AMP binding site [chemical binding]; other site
1127134012439	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012440	Condensation domain; Region: Condensation; pfam00668
1127134012441	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012442	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012443	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012444	acyl-activating enzyme (AAE) consensus motif; other site
1127134012445	AMP binding site [chemical binding]; other site
1127134012446	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012447	Condensation domain; Region: Condensation; pfam00668
1127134012448	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012449	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012450	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012451	acyl-activating enzyme (AAE) consensus motif; other site
1127134012452	AMP binding site [chemical binding]; other site
1127134012453	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012454	peptide synthase; Provisional; Region: PRK12467
1127134012455	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012456	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012457	acyl-activating enzyme (AAE) consensus motif; other site
1127134012458	AMP binding site [chemical binding]; other site
1127134012459	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012460	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012461	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012462	acyl-activating enzyme (AAE) consensus motif; other site
1127134012463	AMP binding site [chemical binding]; other site
1127134012464	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012465	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1127134012466	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012467	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012468	acyl-activating enzyme (AAE) consensus motif; other site
1127134012469	AMP binding site [chemical binding]; other site
1127134012470	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012471	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012472	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012473	acyl-activating enzyme (AAE) consensus motif; other site
1127134012474	AMP binding site [chemical binding]; other site
1127134012475	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134012476	Condensation domain; Region: Condensation; pfam00668
1127134012477	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012478	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012479	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012480	acyl-activating enzyme (AAE) consensus motif; other site
1127134012481	AMP binding site [chemical binding]; other site
1127134012482	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012483	Condensation domain; Region: Condensation; pfam00668
1127134012484	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012485	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012486	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012487	acyl-activating enzyme (AAE) consensus motif; other site
1127134012488	AMP binding site [chemical binding]; other site
1127134012489	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012490	Condensation domain; Region: Condensation; pfam00668
1127134012491	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012492	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012493	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012494	acyl-activating enzyme (AAE) consensus motif; other site
1127134012495	AMP binding site [chemical binding]; other site
1127134012496	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012497	Condensation domain; Region: Condensation; pfam00668
1127134012498	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012499	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012500	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012501	acyl-activating enzyme (AAE) consensus motif; other site
1127134012502	AMP binding site [chemical binding]; other site
1127134012503	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012504	Condensation domain; Region: Condensation; pfam00668
1127134012505	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1127134012506	Condensation domain; Region: Condensation; pfam00668
1127134012507	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012508	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134012509	acyl-activating enzyme (AAE) consensus motif; other site
1127134012510	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1127134012511	large tegument protein UL36; Provisional; Region: PHA03247
1127134012512	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
1127134012513	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134012514	non-specific DNA binding site [nucleotide binding]; other site
1127134012515	salt bridge; other site
1127134012516	sequence-specific DNA binding site [nucleotide binding]; other site
1127134012517	EspG family; Region: ESX-1_EspG; pfam14011
1127134012518	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1127134012519	active site
1127134012520	SAM binding site [chemical binding]; other site
1127134012521	homodimer interface [polypeptide binding]; other site
1127134012522	PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618
1127134012523	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1127134012524	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1127134012525	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1127134012526	dimerization interface [polypeptide binding]; other site
1127134012527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134012528	metabolite-proton symporter; Region: 2A0106; TIGR00883
1127134012529	putative substrate translocation pore; other site
1127134012530	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
1127134012531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134012532	NAD(P) binding site [chemical binding]; other site
1127134012533	active site
1127134012534	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012535	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012536	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1127134012537	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134012538	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134012539	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1127134012540	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134012541	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1127134012542	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1127134012543	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134012544	carboxyltransferase (CT) interaction site; other site
1127134012545	biotinylation site [posttranslational modification]; other site
1127134012546	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134012547	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134012548	active site
1127134012549	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1127134012550	putative active site [active]
1127134012551	putative catalytic site [active]
1127134012552	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1127134012553	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
1127134012554	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
1127134012555	acyl-activating enzyme (AAE) consensus motif; other site
1127134012556	putative AMP binding site [chemical binding]; other site
1127134012557	putative active site [active]
1127134012558	putative CoA binding site [chemical binding]; other site
1127134012559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012562	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012563	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012564	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012565	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012566	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012567	mce related protein; Region: MCE; pfam02470
1127134012568	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012569	mce related protein; Region: MCE; pfam02470
1127134012570	mce related protein; Region: MCE; pfam02470
1127134012571	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012572	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012573	mce related protein; Region: MCE; pfam02470
1127134012574	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012575	mce related protein; Region: MCE; pfam02470
1127134012576	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012577	mce related protein; Region: MCE; pfam02470
1127134012578	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134012579	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134012580	Permease; Region: Permease; pfam02405
1127134012581	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134012582	Permease; Region: Permease; pfam02405
1127134012583	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
1127134012584	The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762
1127134012585	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1127134012586	putative [Fe4-S4] binding site [ion binding]; other site
1127134012587	putative molybdopterin cofactor binding site [chemical binding]; other site
1127134012588	The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782
1127134012589	putative molybdopterin cofactor binding site; other site
1127134012590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251
1127134012591	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012592	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134012593	acyl-activating enzyme (AAE) consensus motif; other site
1127134012594	AMP binding site [chemical binding]; other site
1127134012595	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012596	Condensation domain; Region: Condensation; pfam00668
1127134012597	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012598	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012599	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012600	acyl-activating enzyme (AAE) consensus motif; other site
1127134012601	AMP binding site [chemical binding]; other site
1127134012602	Condensation domain; Region: Condensation; pfam00668
1127134012603	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012604	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012605	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012606	acyl-activating enzyme (AAE) consensus motif; other site
1127134012607	AMP binding site [chemical binding]; other site
1127134012608	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012609	Condensation domain; Region: Condensation; pfam00668
1127134012610	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012611	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012612	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012613	acyl-activating enzyme (AAE) consensus motif; other site
1127134012614	AMP binding site [chemical binding]; other site
1127134012615	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012616	Condensation domain; Region: Condensation; pfam00668
1127134012617	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012618	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012619	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012620	acyl-activating enzyme (AAE) consensus motif; other site
1127134012621	AMP binding site [chemical binding]; other site
1127134012622	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012623	Condensation domain; Region: Condensation; pfam00668
1127134012624	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012625	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012626	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012627	acyl-activating enzyme (AAE) consensus motif; other site
1127134012628	AMP binding site [chemical binding]; other site
1127134012629	Condensation domain; Region: Condensation; pfam00668
1127134012630	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012631	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012632	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012633	acyl-activating enzyme (AAE) consensus motif; other site
1127134012634	AMP binding site [chemical binding]; other site
1127134012635	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012636	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1127134012637	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012638	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012639	acyl-activating enzyme (AAE) consensus motif; other site
1127134012640	AMP binding site [chemical binding]; other site
1127134012641	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012642	Condensation domain; Region: Condensation; pfam00668
1127134012643	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012644	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134012645	acyl-activating enzyme (AAE) consensus motif; other site
1127134012646	AMP binding site [chemical binding]; other site
1127134012647	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012648	Condensation domain; Region: Condensation; pfam00668
1127134012649	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012650	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012651	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012652	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1127134012653	acyl-activating enzyme (AAE) consensus motif; other site
1127134012654	AMP binding site [chemical binding]; other site
1127134012655	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012656	Condensation domain; Region: Condensation; pfam00668
1127134012657	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012658	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012659	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012660	acyl-activating enzyme (AAE) consensus motif; other site
1127134012661	AMP binding site [chemical binding]; other site
1127134012662	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012663	Condensation domain; Region: Condensation; pfam00668
1127134012664	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012665	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012666	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012667	acyl-activating enzyme (AAE) consensus motif; other site
1127134012668	AMP binding site [chemical binding]; other site
1127134012669	Condensation domain; Region: Condensation; pfam00668
1127134012670	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012671	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012672	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1127134012673	acyl-activating enzyme (AAE) consensus motif; other site
1127134012674	AMP binding site [chemical binding]; other site
1127134012675	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1127134012676	Condensation domain; Region: Condensation; pfam00668
1127134012677	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1127134012678	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1127134012679	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1127134012680	dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970
1127134012681	lycopene cyclase; Region: lycopene_cycl; TIGR01789
1127134012682	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134012683	mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965
1127134012684	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1127134012685	active site
1127134012686	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
1127134012687	mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962
1127134012688	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1127134012689	FeS/SAM binding site; other site
1127134012690	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1127134012691	mycofactocin precursor; Region: mycofactocin; TIGR03969
1127134012692	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1127134012693	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012694	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134012695	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1127134012696	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1127134012697	FAD binding pocket [chemical binding]; other site
1127134012698	FAD binding motif [chemical binding]; other site
1127134012699	phosphate binding motif [ion binding]; other site
1127134012700	beta-alpha-beta structure motif; other site
1127134012701	NAD(p) ribose binding residues [chemical binding]; other site
1127134012702	NAD binding pocket [chemical binding]; other site
1127134012703	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1127134012704	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134012705	catalytic loop [active]
1127134012706	iron binding site [ion binding]; other site
1127134012707	Secretory lipase; Region: LIP; pfam03583
1127134012708	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012709	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012710	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1127134012711	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134012712	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1127134012713	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1127134012714	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1127134012715	active site
1127134012716	elongation factor Tu; Reviewed; Region: PRK00049
1127134012717	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1127134012718	G1 box; other site
1127134012719	GEF interaction site [polypeptide binding]; other site
1127134012720	GTP/Mg2+ binding site [chemical binding]; other site
1127134012721	Switch I region; other site
1127134012722	G2 box; other site
1127134012723	G3 box; other site
1127134012724	Switch II region; other site
1127134012725	G4 box; other site
1127134012726	G5 box; other site
1127134012727	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
1127134012728	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1127134012729	Antibiotic Binding Site [chemical binding]; other site
1127134012730	elongation factor G; Reviewed; Region: PRK00007
1127134012731	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1127134012732	G1 box; other site
1127134012733	putative GEF interaction site [polypeptide binding]; other site
1127134012734	GTP/Mg2+ binding site [chemical binding]; other site
1127134012735	Switch I region; other site
1127134012736	G2 box; other site
1127134012737	G3 box; other site
1127134012738	Switch II region; other site
1127134012739	G4 box; other site
1127134012740	G5 box; other site
1127134012741	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1127134012742	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1127134012743	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1127134012744	30S ribosomal protein S7; Validated; Region: PRK05302
1127134012745	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1127134012746	S17 interaction site [polypeptide binding]; other site
1127134012747	S8 interaction site; other site
1127134012748	16S rRNA interaction site [nucleotide binding]; other site
1127134012749	streptomycin interaction site [chemical binding]; other site
1127134012750	23S rRNA interaction site [nucleotide binding]; other site
1127134012751	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1127134012752	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134012753	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134012754	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1127134012755	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1127134012756	dimer interface [polypeptide binding]; other site
1127134012757	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1127134012758	active site
1127134012759	Fe binding site [ion binding]; other site
1127134012760	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1127134012761	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134012762	putative DNA binding site [nucleotide binding]; other site
1127134012763	putative Zn2+ binding site [ion binding]; other site
1127134012764	AsnC family; Region: AsnC_trans_reg; pfam01037
1127134012765	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1127134012766	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1127134012767	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1127134012768	NAD(P) binding site [chemical binding]; other site
1127134012769	Protein of unknown function (DUF2580); Region: DUF2580; pfam10824
1127134012770	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1127134012771	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1127134012772	catalytic residue [active]
1127134012773	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1127134012774	active site
1127134012775	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134012776	active site 2 [active]
1127134012777	Ferredoxin [Energy production and conversion]; Region: COG1146
1127134012778	4Fe-4S binding domain; Region: Fer4; pfam00037
1127134012779	ferredoxin-NADP+ reductase; Region: PLN02852
1127134012780	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134012781	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134012782	catalytic core [active]
1127134012783	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134012784	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1127134012785	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134012786	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1127134012787	DNA binding residues [nucleotide binding]
1127134012788	putative dimer interface [polypeptide binding]; other site
1127134012789	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134012790	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134012791	active site
1127134012792	catalytic tetrad [active]
1127134012793	Evidence 4 : Homologs of previously reported genes of unknown function
1127134012794	Evidence 4 : Homologs of previously reported genes of unknown function
1127134012795	Pirin-related protein [General function prediction only]; Region: COG1741
1127134012796	Pirin; Region: Pirin; pfam02678
1127134012797	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1127134012798	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826
1127134012799	putative hydrophobic ligand binding site [chemical binding]; other site
1127134012800	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134012801	putative DNA binding site [nucleotide binding]; other site
1127134012802	putative Zn2+ binding site [ion binding]; other site
1127134012803	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1127134012804	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1127134012805	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1127134012806	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1127134012807	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1127134012808	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
1127134012809	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1127134012810	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1127134012811	G-loop; other site
1127134012812	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1127134012813	DNA binding site [nucleotide binding]
1127134012814	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1127134012815	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1127134012816	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1127134012817	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1127134012818	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1127134012819	RPB1 interaction site [polypeptide binding]; other site
1127134012820	RPB10 interaction site [polypeptide binding]; other site
1127134012821	RPB11 interaction site [polypeptide binding]; other site
1127134012822	RPB3 interaction site [polypeptide binding]; other site
1127134012823	RPB12 interaction site [polypeptide binding]; other site
1127134012824	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012825	mce related protein; Region: MCE; pfam02470
1127134012826	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012827	mce related protein; Region: MCE; pfam02470
1127134012828	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134012829	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012830	mce related protein; Region: MCE; pfam02470
1127134012831	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012832	mce related protein; Region: MCE; pfam02470
1127134012833	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134012834	mce related protein; Region: MCE; pfam02470
1127134012835	mce related protein; Region: MCE; pfam02470
1127134012836	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134012837	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134012838	Permease; Region: Permease; pfam02405
1127134012839	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134012840	Permease; Region: Permease; pfam02405
1127134012841	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1127134012842	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1127134012843	Walker A/P-loop; other site
1127134012844	ATP binding site [chemical binding]; other site
1127134012845	Q-loop/lid; other site
1127134012846	ABC transporter signature motif; other site
1127134012847	Walker B; other site
1127134012848	D-loop; other site
1127134012849	H-loop/switch region; other site
1127134012850	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1127134012851	core dimer interface [polypeptide binding]; other site
1127134012852	peripheral dimer interface [polypeptide binding]; other site
1127134012853	L10 interface [polypeptide binding]; other site
1127134012854	L11 interface [polypeptide binding]; other site
1127134012855	putative EF-Tu interaction site [polypeptide binding]; other site
1127134012856	putative EF-G interaction site [polypeptide binding]; other site
1127134012857	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1127134012858	23S rRNA interface [nucleotide binding]; other site
1127134012859	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1127134012860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134012861	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1127134012862	putative substrate translocation pore; other site
1127134012863	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134012864	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1127134012865	mRNA/rRNA interface [nucleotide binding]; other site
1127134012866	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1127134012867	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1127134012868	23S rRNA interface [nucleotide binding]; other site
1127134012869	L7/L12 interface [polypeptide binding]; other site
1127134012870	putative thiostrepton binding site; other site
1127134012871	L25 interface [polypeptide binding]; other site
1127134012872	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1127134012873	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1127134012874	putative homodimer interface [polypeptide binding]; other site
1127134012875	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1127134012876	heterodimer interface [polypeptide binding]; other site
1127134012877	homodimer interface [polypeptide binding]; other site
1127134012878	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1127134012879	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134012880	active site
1127134012881	catalytic site [active]
1127134012882	SAV4209_like.  Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453
1127134012883	active site
1127134012884	catalytic site [active]
1127134012885	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
1127134012886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1127134012887	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1127134012888	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1127134012889	heat shock protein HtpX; Provisional; Region: PRK03072
1127134012890	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1127134012891	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1127134012892	substrate binding pocket [chemical binding]; other site
1127134012893	chain length determination region; other site
1127134012894	substrate-Mg2+ binding site; other site
1127134012895	catalytic residues [active]
1127134012896	aspartate-rich region 1; other site
1127134012897	active site lid residues [active]
1127134012898	aspartate-rich region 2; other site
1127134012899	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1127134012900	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134012901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134012902	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1127134012903	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134012904	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1127134012905	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1127134012906	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134012907	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1127134012908	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134012909	Cytochrome P450; Region: p450; cl12078
1127134012910	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
1127134012911	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
1127134012912	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1127134012913	DNA binding site [nucleotide binding]
1127134012914	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1127134012915	Predicted ATPase [General function prediction only]; Region: COG3903
1127134012916	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134012917	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1127134012918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134012919	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134012920	Walker A/P-loop; other site
1127134012921	ATP binding site [chemical binding]; other site
1127134012922	Q-loop/lid; other site
1127134012923	ABC transporter signature motif; other site
1127134012924	Walker B; other site
1127134012925	D-loop; other site
1127134012926	H-loop/switch region; other site
1127134012927	Predicted membrane protein [Function unknown]; Region: COG2246
1127134012928	GtrA-like protein; Region: GtrA; pfam04138
1127134012929	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134012930	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134012931	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1127134012932	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1127134012933	active site
1127134012934	catalytic tetrad [active]
1127134012935	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1127134012936	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1127134012937	[4Fe-4S] binding site [ion binding]; other site
1127134012938	molybdopterin cofactor binding site; other site
1127134012939	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1127134012940	molybdopterin cofactor binding site; other site
1127134012941	Flavodoxin; Region: Flavodoxin_1; pfam00258
1127134012942	FAD binding domain; Region: FAD_binding_1; pfam00667
1127134012943	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1127134012944	FAD binding pocket [chemical binding]; other site
1127134012945	FAD binding motif [chemical binding]; other site
1127134012946	catalytic residues [active]
1127134012947	NAD binding pocket [chemical binding]; other site
1127134012948	phosphate binding motif [ion binding]; other site
1127134012949	beta-alpha-beta structure motif; other site
1127134012950	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1127134012951	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134012952	S-adenosylmethionine binding site [chemical binding]; other site
1127134012953	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
1127134012954	TIGR03086 family protein; Region: TIGR03086
1127134012955	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134012956	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1127134012957	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1127134012958	dimer interface [polypeptide binding]; other site
1127134012959	tetramer interface [polypeptide binding]; other site
1127134012960	PYR/PP interface [polypeptide binding]; other site
1127134012961	TPP binding site [chemical binding]; other site
1127134012962	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1127134012963	TPP-binding site; other site
1127134012964	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
1127134012965	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1127134012966	FAD binding pocket [chemical binding]; other site
1127134012967	FAD binding motif [chemical binding]; other site
1127134012968	phosphate binding motif [ion binding]; other site
1127134012969	NAD binding pocket [chemical binding]; other site
1127134012970	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134012971	CoenzymeA binding site [chemical binding]; other site
1127134012972	subunit interaction site [polypeptide binding]; other site
1127134012973	PHB binding site; other site
1127134012974	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1127134012975	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134012976	substrate binding site [chemical binding]; other site
1127134012977	oxyanion hole (OAH) forming residues; other site
1127134012978	trimer interface [polypeptide binding]; other site
1127134012979	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134012980	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1127134012981	active site
1127134012982	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134012983	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
1127134012984	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134012985	acyl-activating enzyme (AAE) consensus motif; other site
1127134012986	acyl-activating enzyme (AAE) consensus motif; other site
1127134012987	AMP binding site [chemical binding]; other site
1127134012988	active site
1127134012989	CoA binding site [chemical binding]; other site
1127134012990	Predicted flavoprotein [General function prediction only]; Region: COG0431
1127134012991	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134012992	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134012993	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134012994	Walker A/P-loop; other site
1127134012995	ATP binding site [chemical binding]; other site
1127134012996	Q-loop/lid; other site
1127134012997	ABC transporter signature motif; other site
1127134012998	Walker B; other site
1127134012999	D-loop; other site
1127134013000	H-loop/switch region; other site
1127134013001	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134013002	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1127134013003	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
1127134013004	Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : putative regulator
1127134013005	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
1127134013006	putative hydrophobic ligand binding site [chemical binding]; other site
1127134013007	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
1127134013008	UbiA prenyltransferase family; Region: UbiA; pfam01040
1127134013009	Predicted membrane protein [Function unknown]; Region: COG1950
1127134013010	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134013011	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893
1127134013012	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1127134013013	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
1127134013014	acyl-activating enzyme (AAE) consensus motif; other site
1127134013015	putative AMP binding site [chemical binding]; other site
1127134013016	putative active site [active]
1127134013017	putative CoA binding site [chemical binding]; other site
1127134013018	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013019	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013020	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1127134013021	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1127134013022	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134013023	catalytic residue [active]
1127134013024	Protein of unknown function (DUF4229); Region: DUF4229; pfam14012
1127134013025	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
1127134013026	DNA binding residues [nucleotide binding]
1127134013027	Secretory lipase; Region: LIP; pfam03583
1127134013028	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013029	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013030	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1127134013031	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333
1127134013032	ResB-like family; Region: ResB; pfam05140
1127134013033	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1127134013034	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1127134013035	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1127134013036	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1127134013037	catalytic residues [active]
1127134013038	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134013039	catalytic core [active]
1127134013040	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1127134013041	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134013042	inhibitor-cofactor binding pocket; inhibition site
1127134013043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134013044	catalytic residue [active]
1127134013045	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1127134013046	dimer interface [polypeptide binding]; other site
1127134013047	active site
1127134013048	Schiff base residues; other site
1127134013049	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815
1127134013050	active site
1127134013051	homodimer interface [polypeptide binding]; other site
1127134013052	SAM binding site [chemical binding]; other site
1127134013053	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1127134013054	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1127134013055	active site
1127134013056	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1127134013057	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1127134013058	domain interfaces; other site
1127134013059	active site
1127134013060	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1127134013061	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1127134013062	tRNA; other site
1127134013063	putative tRNA binding site [nucleotide binding]; other site
1127134013064	putative NADP binding site [chemical binding]; other site
1127134013065	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1127134013066	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1127134013067	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1127134013068	CoA binding domain; Region: CoA_binding; smart00881
1127134013069	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1127134013070	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1127134013071	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1127134013072	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134013073	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1127134013074	putative acyl-acceptor binding pocket; other site
1127134013075	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134013076	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1127134013077	NAD(P) binding site [chemical binding]; other site
1127134013078	active site
1127134013079	DNA binding domain, excisionase family; Region: excise; TIGR01764
1127134013080	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1127134013081	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1127134013082	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1127134013083	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1127134013084	active site 2 [active]
1127134013085	active site 1 [active]
1127134013086	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1127134013087	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1127134013088	DNA interaction; other site
1127134013089	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1127134013090	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1127134013091	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1127134013092	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1127134013093	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134013094	active site
1127134013095	phosphorylation site [posttranslational modification]
1127134013096	intermolecular recognition site; other site
1127134013097	dimerization interface [polypeptide binding]; other site
1127134013098	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1127134013099	DNA binding site [nucleotide binding]
1127134013100	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1127134013101	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1127134013102	dimer interface [polypeptide binding]; other site
1127134013103	phosphorylation site [posttranslational modification]
1127134013104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134013105	ATP binding site [chemical binding]; other site
1127134013106	Mg2+ binding site [ion binding]; other site
1127134013107	G-X-G motif; other site
1127134013108	Predicted acyl esterases [General function prediction only]; Region: COG2936
1127134013109	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134013110	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1127134013111	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134013112	catalytic core [active]
1127134013113	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1127134013114	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1127134013115	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134013116	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1127134013117	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1127134013118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134013119	NAD(P) binding site [chemical binding]; other site
1127134013120	active site
1127134013121	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134013122	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134013123	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134013124	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1127134013125	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1127134013126	putative ADP-binding pocket [chemical binding]; other site
1127134013127	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1127134013128	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431
1127134013129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1127134013130	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1127134013131	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1127134013132	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
1127134013133	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134013134	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1127134013135	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1127134013136	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
1127134013137	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134013138	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134013139	non-specific DNA binding site [nucleotide binding]; other site
1127134013140	salt bridge; other site
1127134013141	sequence-specific DNA binding site [nucleotide binding]; other site
1127134013142	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134013143	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1127134013144	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1127134013145	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1127134013146	putative active site [active]
1127134013147	putative substrate binding site [chemical binding]; other site
1127134013148	putative cosubstrate binding site; other site
1127134013149	catalytic site [active]
1127134013150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134013151	Coenzyme A binding pocket [chemical binding]; other site
1127134013152	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1127134013153	intersubunit interface [polypeptide binding]; other site
1127134013154	catalytic residue [active]
1127134013155	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1127134013156	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1127134013157	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134013158	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134013159	Protein of unknown function (DUF2516); Region: DUF2516; pfam10724
1127134013160	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134013161	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134013162	non-specific DNA binding site [nucleotide binding]; other site
1127134013163	salt bridge; other site
1127134013164	sequence-specific DNA binding site [nucleotide binding]; other site
1127134013165	Predicted membrane protein [Function unknown]; Region: COG2733
1127134013166	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013167	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013168	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1127134013169	ABC1 family; Region: ABC1; pfam03109
1127134013170	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1127134013171	active site
1127134013172	ATP binding site [chemical binding]; other site
1127134013173	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1127134013174	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1127134013175	NAD(P) binding pocket [chemical binding]; other site
1127134013176	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1127134013177	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134013178	S-adenosylmethionine binding site [chemical binding]; other site
1127134013179	EspG family; Region: ESX-1_EspG; pfam14011
1127134013180	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1127134013181	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
1127134013182	Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479
1127134013183	LGFP repeat; Region: LGFP; pfam08310
1127134013184	LGFP repeat; Region: LGFP; pfam08310
1127134013185	LGFP repeat; Region: LGFP; pfam08310
1127134013186	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1127134013187	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1127134013188	putative substrate binding site [chemical binding]; other site
1127134013189	putative ATP binding site [chemical binding]; other site
1127134013190	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1127134013191	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1127134013192	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1127134013193	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1127134013194	protein binding site [polypeptide binding]; other site
1127134013195	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
1127134013196	putative active site [active]
1127134013197	redox center [active]
1127134013198	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1127134013199	Thioredoxin; Region: Thioredoxin_4; cl17273
1127134013200	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134013201	substrate binding pocket [chemical binding]; other site
1127134013202	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1127134013203	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1127134013204	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1127134013205	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134013206	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1127134013207	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1127134013208	putative NAD(P) binding site [chemical binding]; other site
1127134013209	putative substrate binding site [chemical binding]; other site
1127134013210	catalytic Zn binding site [ion binding]; other site
1127134013211	structural Zn binding site [ion binding]; other site
1127134013212	dimer interface [polypeptide binding]; other site
1127134013213	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1127134013214	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1127134013215	ATP binding site [chemical binding]; other site
1127134013216	Mg++ binding site [ion binding]; other site
1127134013217	motif III; other site
1127134013218	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1127134013219	nucleotide binding region [chemical binding]; other site
1127134013220	ATP-binding site [chemical binding]; other site
1127134013221	acyltransferase PapA5; Provisional; Region: PRK09294
1127134013222	acyltransferase PapA5; Provisional; Region: PRK09294
1127134013223	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013224	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013225	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1127134013226	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1127134013227	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1127134013228	THF binding site; other site
1127134013229	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1127134013230	substrate binding site [chemical binding]; other site
1127134013231	THF binding site; other site
1127134013232	zinc-binding site [ion binding]; other site
1127134013233	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819
1127134013234	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1127134013235	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1127134013236	isocitrate lyase; Provisional; Region: PRK15063
1127134013237	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
1127134013238	tetramer interface [polypeptide binding]; other site
1127134013239	active site
1127134013240	Mg2+/Mn2+ binding site [ion binding]; other site
1127134013241	Secretory lipase; Region: LIP; pfam03583
1127134013242	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134013243	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1127134013244	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1127134013245	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1127134013246	Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201
1127134013247	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1127134013248	ATP binding site [chemical binding]; other site
1127134013249	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134013250	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134013251	non-specific DNA binding site [nucleotide binding]; other site
1127134013252	salt bridge; other site
1127134013253	sequence-specific DNA binding site [nucleotide binding]; other site
1127134013254	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1127134013255	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1127134013256	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1127134013257	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180
1127134013258	Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901
1127134013259	active site
1127134013260	DNA binding site [nucleotide binding]
1127134013261	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1127134013262	DNA binding site [nucleotide binding]
1127134013263	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134013264	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
1127134013265	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1127134013266	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1127134013267	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1127134013268	Protein of unknown function (DUF3349); Region: DUF3349; pfam11829
1127134013269	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1127134013270	putative substrate translocation pore; other site
1127134013271	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013272	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013273	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1127134013274	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1127134013275	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134013276	active site
1127134013277	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1127134013278	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1127134013279	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1127134013280	putative ligand binding site [chemical binding]; other site
1127134013281	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1127134013282	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1127134013283	TM-ABC transporter signature motif; other site
1127134013284	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1127134013285	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1127134013286	TM-ABC transporter signature motif; other site
1127134013287	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1127134013288	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1127134013289	Walker A/P-loop; other site
1127134013290	ATP binding site [chemical binding]; other site
1127134013291	Q-loop/lid; other site
1127134013292	ABC transporter signature motif; other site
1127134013293	Walker B; other site
1127134013294	D-loop; other site
1127134013295	H-loop/switch region; other site
1127134013296	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1127134013297	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1127134013298	Walker A/P-loop; other site
1127134013299	ATP binding site [chemical binding]; other site
1127134013300	Q-loop/lid; other site
1127134013301	ABC transporter signature motif; other site
1127134013302	Walker B; other site
1127134013303	D-loop; other site
1127134013304	H-loop/switch region; other site
1127134013305	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1127134013306	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134013307	DNA-binding site [nucleotide binding]; DNA binding site
1127134013308	FCD domain; Region: FCD; pfam07729
1127134013309	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134013310	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
1127134013311	putative dimer interface [polypeptide binding]; other site
1127134013312	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013313	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1127134013314	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1127134013315	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1127134013316	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1127134013317	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1127134013318	Patatin-like phospholipase; Region: Patatin; pfam01734
1127134013319	active site
1127134013320	nucleophile elbow; other site
1127134013321	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818
1127134013322	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134013323	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1127134013324	MarR family; Region: MarR_2; cl17246
1127134013325	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134013326	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134013327	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134013328	Helix-turn-helix domain; Region: HTH_18; pfam12833
1127134013329	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1127134013330	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1127134013331	NAD(P) binding site [chemical binding]; other site
1127134013332	substrate binding site [chemical binding]; other site
1127134013333	dimer interface [polypeptide binding]; other site
1127134013334	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1127134013335	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134013336	active site
1127134013337	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1127134013338	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1127134013339	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1127134013340	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134013341	MarR family; Region: MarR_2; pfam12802
1127134013342	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1127134013343	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134013344	active site
1127134013345	motif I; other site
1127134013346	motif II; other site
1127134013347	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134013348	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013349	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013350	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134013351	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134013352	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1127134013353	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1127134013354	ring oligomerisation interface [polypeptide binding]; other site
1127134013355	ATP/Mg binding site [chemical binding]; other site
1127134013356	stacking interactions; other site
1127134013357	hinge regions; other site
1127134013358	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134013359	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134013360	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1127134013361	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134013362	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1127134013363	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1127134013364	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134013365	DNA binding residues [nucleotide binding]
1127134013366	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1127134013367	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1127134013368	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
1127134013369	Predicted membrane protein [Function unknown]; Region: COG2261
1127134013370	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1127134013371	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1127134013372	dimer interface [polypeptide binding]; other site
1127134013373	active site
1127134013374	CoA binding pocket [chemical binding]; other site
1127134013375	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1127134013376	hydrophobic ligand binding site; other site
1127134013377	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1127134013378	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134013379	active site
1127134013380	phosphorylation site [posttranslational modification]
1127134013381	intermolecular recognition site; other site
1127134013382	dimerization interface [polypeptide binding]; other site
1127134013383	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1127134013384	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134013385	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134013386	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1127134013387	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1127134013388	ligand binding site [chemical binding]; other site
1127134013389	flexible hinge region; other site
1127134013390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1127134013391	ATP binding site [chemical binding]; other site
1127134013392	Mg2+ binding site [ion binding]; other site
1127134013393	G-X-G motif; other site
1127134013394	Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148
1127134013395	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
1127134013396	Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073
1127134013397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134013398	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1127134013399	Walker A motif; other site
1127134013400	ATP binding site [chemical binding]; other site
1127134013401	Walker B motif; other site
1127134013402	arginine finger; other site
1127134013403	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134013404	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1127134013405	Walker A motif; other site
1127134013406	ATP binding site [chemical binding]; other site
1127134013407	Walker B motif; other site
1127134013408	arginine finger; other site
1127134013409	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644
1127134013410	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1127134013411	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1127134013412	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1127134013413	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1127134013414	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946
1127134013415	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665
1127134013416	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1127134013417	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1127134013418	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK07948
1127134013419	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1127134013420	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
1127134013421	active site
1127134013422	carboxylate-amine ligase; Provisional; Region: PRK13517
1127134013423	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
1127134013424	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1127134013425	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1127134013426	E-class dimer interface [polypeptide binding]; other site
1127134013427	P-class dimer interface [polypeptide binding]; other site
1127134013428	active site
1127134013429	Cu2+ binding site [ion binding]; other site
1127134013430	Zn2+ binding site [ion binding]; other site
1127134013431	Protein of unknown function (DUF3263); Region: DUF3263; pfam11662
1127134013432	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1127134013433	active site
1127134013434	catalytic residues [active]
1127134013435	metal binding site [ion binding]; metal-binding site
1127134013436	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1127134013437	Coenzyme A binding pocket [chemical binding]; other site
1127134013438	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1127134013439	putative catalytic site [active]
1127134013440	putative phosphate binding site [ion binding]; other site
1127134013441	active site
1127134013442	metal binding site A [ion binding]; metal-binding site
1127134013443	DNA binding site [nucleotide binding]
1127134013444	putative AP binding site [nucleotide binding]; other site
1127134013445	putative metal binding site B [ion binding]; other site
1127134013446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013448	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1127134013449	fumarylacetoacetase; Region: PLN02856
1127134013450	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1127134013451	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1127134013452	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1127134013453	dimer interface [polypeptide binding]; other site
1127134013454	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1127134013455	ThiC-associated domain; Region: ThiC-associated; pfam13667
1127134013456	ThiC family; Region: ThiC; pfam01964
1127134013457	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134013458	CoenzymeA binding site [chemical binding]; other site
1127134013459	subunit interaction site [polypeptide binding]; other site
1127134013460	PHB binding site; other site
1127134013461	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134013462	Permease; Region: Permease; pfam02405
1127134013463	Permease; Region: Permease; pfam02405
1127134013464	MoxR-like ATPases [General function prediction only]; Region: COG0714
1127134013465	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134013466	Walker A motif; other site
1127134013467	ATP binding site [chemical binding]; other site
1127134013468	Walker B motif; other site
1127134013469	arginine finger; other site
1127134013470	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1127134013471	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1127134013472	Protein of unknown function DUF58; Region: DUF58; pfam01882
1127134013473	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1127134013474	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1127134013475	Zn2+ binding site [ion binding]; other site
1127134013476	Mg2+ binding site [ion binding]; other site
1127134013477	MMPL family; Region: MMPL; pfam03176
1127134013478	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
1127134013479	DNA binding site [nucleotide binding]
1127134013480	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1127134013481	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1127134013482	NAD(P) binding site [chemical binding]; other site
1127134013483	catalytic residues [active]
1127134013484	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134013485	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134013486	active site
1127134013487	acetylornithine aminotransferase; Provisional; Region: PRK02627
1127134013488	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1127134013489	inhibitor-cofactor binding pocket; inhibition site
1127134013490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134013491	catalytic residue [active]
1127134013492	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134013493	hydrophobic ligand binding site; other site
1127134013494	Domain of unknown function (DUF4260); Region: DUF4260; pfam14079
1127134013495	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1127134013496	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1127134013497	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1127134013498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134013499	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1127134013500	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1127134013501	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013502	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013503	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1127134013504	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134013505	substrate binding pocket [chemical binding]; other site
1127134013506	membrane-bound complex binding site; other site
1127134013507	hinge residues; other site
1127134013508	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1127134013509	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134013510	Walker A/P-loop; other site
1127134013511	ATP binding site [chemical binding]; other site
1127134013512	Q-loop/lid; other site
1127134013513	ABC transporter signature motif; other site
1127134013514	Walker B; other site
1127134013515	D-loop; other site
1127134013516	H-loop/switch region; other site
1127134013517	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1127134013518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1127134013519	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1127134013520	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1127134013521	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1127134013522	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1127134013523	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134013524	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013526	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1127134013527	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134013528	NAD binding site [chemical binding]; other site
1127134013529	substrate binding site [chemical binding]; other site
1127134013530	putative active site [active]
1127134013531	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910
1127134013532	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1127134013533	dimer interface [polypeptide binding]; other site
1127134013534	active site
1127134013535	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013536	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013537	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1127134013538	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1127134013539	dimer interface [polypeptide binding]; other site
1127134013540	substrate binding site [chemical binding]; other site
1127134013541	ATP binding site [chemical binding]; other site
1127134013542	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013543	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013544	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
1127134013545	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1127134013546	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1127134013547	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1127134013548	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013549	enoyl-CoA hydratase; Provisional; Region: PRK07827
1127134013550	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134013551	substrate binding site [chemical binding]; other site
1127134013552	oxyanion hole (OAH) forming residues; other site
1127134013553	trimer interface [polypeptide binding]; other site
1127134013554	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1127134013555	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134013556	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1127134013557	active site
1127134013558	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1127134013559	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1127134013560	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1127134013561	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1127134013562	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1127134013563	carboxyltransferase (CT) interaction site; other site
1127134013564	biotinylation site [posttranslational modification]; other site
1127134013565	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1127134013566	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1127134013567	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1127134013568	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134013569	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134013570	active site
1127134013571	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
1127134013572	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1127134013573	cyclase homology domain; Region: CHD; cd07302
1127134013574	nucleotidyl binding site; other site
1127134013575	metal binding site [ion binding]; metal-binding site
1127134013576	dimer interface [polypeptide binding]; other site
1127134013577	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1127134013578	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134013579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134013580	Walker A/P-loop; other site
1127134013581	ATP binding site [chemical binding]; other site
1127134013582	Q-loop/lid; other site
1127134013583	ABC transporter signature motif; other site
1127134013584	Walker B; other site
1127134013585	D-loop; other site
1127134013586	H-loop/switch region; other site
1127134013587	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1127134013588	ThiS interaction site; other site
1127134013589	putative active site [active]
1127134013590	tetramer interface [polypeptide binding]; other site
1127134013591	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1127134013592	thiS-thiF/thiG interaction site; other site
1127134013593	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1127134013594	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1127134013595	thiamine phosphate binding site [chemical binding]; other site
1127134013596	active site
1127134013597	pyrophosphate binding site [ion binding]; other site
1127134013598	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1127134013599	nudix motif; other site
1127134013600	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134013601	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1127134013602	substrate binding pocket [chemical binding]; other site
1127134013603	membrane-bound complex binding site; other site
1127134013604	hinge residues; other site
1127134013605	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1127134013606	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1127134013607	active site
1127134013608	ATP binding site [chemical binding]; other site
1127134013609	substrate binding site [chemical binding]; other site
1127134013610	activation loop (A-loop); other site
1127134013611	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1127134013612	propionate/acetate kinase; Provisional; Region: PRK12379
1127134013613	phosphate acetyltransferase; Reviewed; Region: PRK05632
1127134013614	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1127134013615	DRTGG domain; Region: DRTGG; pfam07085
1127134013616	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1127134013617	deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026
1127134013618	glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554
1127134013619	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1127134013620	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1127134013621	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1127134013622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134013623	active site
1127134013624	motif I; other site
1127134013625	motif II; other site
1127134013626	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1127134013627	motif II; other site
1127134013628	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1127134013629	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134013630	PHB binding site; other site
1127134013631	CoenzymeA binding site [chemical binding]; other site
1127134013632	subunit interaction site [polypeptide binding]; other site
1127134013633	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1127134013634	MarR family; Region: MarR_2; pfam12802
1127134013635	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1127134013636	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1127134013637	conserved cys residue [active]
1127134013638	O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810
1127134013639	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134013640	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1127134013641	catalytic residue [active]
1127134013642	Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522
1127134013643	active site residue [active]
1127134013644	ferredoxin-NADP+ reductase; Region: PLN02852
1127134013645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134013646	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1127134013647	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1127134013648	active site
1127134013649	NlpC/P60 family; Region: NLPC_P60; cl17555
1127134013650	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1127134013651	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1127134013652	oligomeric interface; other site
1127134013653	putative active site [active]
1127134013654	homodimer interface [polypeptide binding]; other site
1127134013655	uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083
1127134013656	TIGR03086 family protein; Region: TIGR03086
1127134013657	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK01175
1127134013658	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134013659	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1127134013660	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1127134013661	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1127134013662	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1127134013663	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134013664	DNA-binding site [nucleotide binding]; DNA binding site
1127134013665	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134013666	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134013667	homodimer interface [polypeptide binding]; other site
1127134013668	catalytic residue [active]
1127134013669	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1127134013670	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1127134013671	DNA binding site [nucleotide binding]
1127134013672	active site
1127134013673	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1127134013674	Walker A motif; other site
1127134013675	ATP binding site [chemical binding]; other site
1127134013676	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134013677	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134013678	DNA binding residues [nucleotide binding]
1127134013679	dimerization interface [polypeptide binding]; other site
1127134013680	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1127134013681	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1127134013682	GDP-binding site [chemical binding]; other site
1127134013683	ACT binding site; other site
1127134013684	IMP binding site; other site
1127134013685	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1127134013686	Peptidase family M50; Region: Peptidase_M50; pfam02163
1127134013687	active site
1127134013688	putative substrate binding region [chemical binding]; other site
1127134013689	Predicted membrane protein [Function unknown]; Region: COG4129
1127134013690	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1127134013691	Protein of unknown function (DUF3151); Region: DUF3151; pfam11349
1127134013692	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
1127134013693	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
1127134013694	active site
1127134013695	catalytic site [active]
1127134013696	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134013697	active site 2 [active]
1127134013698	active site 1 [active]
1127134013699	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1127134013700	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
1127134013701	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
1127134013702	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1127134013703	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1127134013704	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1127134013705	phosphopeptide binding site; other site
1127134013706	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1127134013707	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
1127134013708	active site
1127134013709	intersubunit interface [polypeptide binding]; other site
1127134013710	zinc binding site [ion binding]; other site
1127134013711	Na+ binding site [ion binding]; other site
1127134013712	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1127134013713	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1127134013714	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1127134013715	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1127134013716	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134013717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134013718	active site
1127134013719	phosphorylation site [posttranslational modification]
1127134013720	intermolecular recognition site; other site
1127134013721	dimerization interface [polypeptide binding]; other site
1127134013722	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134013723	DNA binding residues [nucleotide binding]
1127134013724	dimerization interface [polypeptide binding]; other site
1127134013725	Putative sensor; Region: Sensor; pfam13796
1127134013726	Histidine kinase; Region: HisKA_3; pfam07730
1127134013727	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134013728	Mg2+ binding site [ion binding]; other site
1127134013729	G-X-G motif; other site
1127134013730	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
1127134013731	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1127134013732	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1127134013733	Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996
1127134013734	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134013735	RibD C-terminal domain; Region: RibD_C; cl17279
1127134013736	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
1127134013737	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1127134013738	putative active site [active]
1127134013739	SnoaL-like domain; Region: SnoaL_2; pfam12680
1127134013740	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
1127134013741	YhhN-like protein; Region: YhhN; pfam07947
1127134013742	3-oxoacyl-(acyl-carrier-protein) synthase III; Region: fabH; TIGR00747
1127134013743	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1127134013744	dimer interface [polypeptide binding]; other site
1127134013745	active site
1127134013746	CoA binding pocket [chemical binding]; other site
1127134013747	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134013748	active site
1127134013749	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1127134013750	Clp amino terminal domain; Region: Clp_N; pfam02861
1127134013751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134013752	Walker A motif; other site
1127134013753	ATP binding site [chemical binding]; other site
1127134013754	Walker B motif; other site
1127134013755	arginine finger; other site
1127134013756	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134013757	Walker A motif; other site
1127134013758	ATP binding site [chemical binding]; other site
1127134013759	Walker B motif; other site
1127134013760	arginine finger; other site
1127134013761	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1127134013762	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1127134013763	heme-binding site [chemical binding]; other site
1127134013764	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1127134013765	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1127134013766	FAD binding pocket [chemical binding]; other site
1127134013767	FAD binding motif [chemical binding]; other site
1127134013768	phosphate binding motif [ion binding]; other site
1127134013769	beta-alpha-beta structure motif; other site
1127134013770	NAD binding pocket [chemical binding]; other site
1127134013771	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1127134013772	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1127134013773	FAD binding pocket [chemical binding]; other site
1127134013774	FAD binding motif [chemical binding]; other site
1127134013775	phosphate binding motif [ion binding]; other site
1127134013776	beta-alpha-beta structure motif; other site
1127134013777	NAD binding pocket [chemical binding]; other site
1127134013778	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1127134013779	heme-binding site [chemical binding]; other site
1127134013780	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
1127134013781	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187
1127134013782	FAD binding pocket [chemical binding]; other site
1127134013783	FAD binding motif [chemical binding]; other site
1127134013784	phosphate binding motif [ion binding]; other site
1127134013785	beta-alpha-beta structure motif; other site
1127134013786	NAD binding pocket [chemical binding]; other site
1127134013787	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1127134013788	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1127134013789	DNA binding residues [nucleotide binding]
1127134013790	chaperone protein DnaJ; Provisional; Region: PRK14279
1127134013791	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1127134013792	HSP70 interaction site [polypeptide binding]; other site
1127134013793	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1127134013794	Zn binding sites [ion binding]; other site
1127134013795	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1127134013796	dimer interface [polypeptide binding]; other site
1127134013797	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1127134013798	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1127134013799	dimer interface [polypeptide binding]; other site
1127134013800	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1127134013801	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1127134013802	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1127134013803	nucleotide binding site [chemical binding]; other site
1127134013804	NEF interaction site [polypeptide binding]; other site
1127134013805	SBD interface [polypeptide binding]; other site
1127134013806	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1127134013807	Phage-related protein [Function unknown]; Region: COG4679
1127134013808	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134013809	non-specific DNA binding site [nucleotide binding]; other site
1127134013810	salt bridge; other site
1127134013811	sequence-specific DNA binding site [nucleotide binding]; other site
1127134013812	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1127134013813	minor groove reading motif; other site
1127134013814	helix-hairpin-helix signature motif; other site
1127134013815	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1127134013816	G1 box; other site
1127134013817	GTP/Mg2+ binding site [chemical binding]; other site
1127134013818	G2 box; other site
1127134013819	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1127134013820	Dynamin family; Region: Dynamin_N; pfam00350
1127134013821	G1 box; other site
1127134013822	GTP/Mg2+ binding site [chemical binding]; other site
1127134013823	G2 box; other site
1127134013824	Switch I region; other site
1127134013825	G3 box; other site
1127134013826	Switch II region; other site
1127134013827	G4 box; other site
1127134013828	G5 box; other site
1127134013829	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134013830	nucleotide binding site [chemical binding]; other site
1127134013831	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134013832	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134013833	DNA binding residues [nucleotide binding]
1127134013834	dimerization interface [polypeptide binding]; other site
1127134013835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1127134013836	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134013837	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134013838	DNA binding residues [nucleotide binding]
1127134013839	dimerization interface [polypeptide binding]; other site
1127134013840	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1127134013841	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1127134013842	4Fe-4S binding domain; Region: Fer4; pfam00037
1127134013843	Cysteine-rich domain; Region: CCG; pfam02754
1127134013844	Cysteine-rich domain; Region: CCG; pfam02754
1127134013845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134013846	NmrA-like family; Region: NmrA; pfam05368
1127134013847	NAD(P) binding site [chemical binding]; other site
1127134013848	active site
1127134013849	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1127134013850	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134013851	active site
1127134013852	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1127134013853	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1127134013854	active site
1127134013855	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1127134013856	putative active site [active]
1127134013857	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1127134013858	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1127134013859	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1127134013860	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1127134013861	nucleotide binding site [chemical binding]; other site
1127134013862	YibE/F-like protein; Region: YibE_F; pfam07907
1127134013863	aminotransferase AlaT; Validated; Region: PRK09265
1127134013864	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134013865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134013866	homodimer interface [polypeptide binding]; other site
1127134013867	catalytic residue [active]
1127134013868	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134013869	non-specific DNA binding site [nucleotide binding]; other site
1127134013870	salt bridge; other site
1127134013871	sequence-specific DNA binding site [nucleotide binding]; other site
1127134013872	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1127134013873	trimer interface [polypeptide binding]; other site
1127134013874	active site
1127134013875	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1127134013876	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1127134013877	amidase; Provisional; Region: PRK07869
1127134013878	Amidase; Region: Amidase; cl11426
1127134013879	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134013880	RibD C-terminal domain; Region: RibD_C; cl17279
1127134013881	Predicted membrane protein [Function unknown]; Region: COG4270
1127134013882	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1127134013883	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1127134013884	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1127134013885	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1127134013886	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134013887	active site
1127134013888	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1127134013889	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1127134013890	active site
1127134013891	dimer interface [polypeptide binding]; other site
1127134013892	non-prolyl cis peptide bond; other site
1127134013893	insertion regions; other site
1127134013894	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1127134013895	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1127134013896	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1127134013897	GAF domain; Region: GAF_2; pfam13185
1127134013898	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1127134013899	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1127134013900	active site
1127134013901	non-prolyl cis peptide bond; other site
1127134013902	sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022
1127134013903	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134013904	active site
1127134013905	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
1127134013906	PemK-like protein; Region: PemK; cl00995
1127134013907	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1127134013908	enoyl-CoA hydratase; Provisional; Region: PRK08252
1127134013909	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134013910	substrate binding site [chemical binding]; other site
1127134013911	oxyanion hole (OAH) forming residues; other site
1127134013912	trimer interface [polypeptide binding]; other site
1127134013913	enoyl-CoA hydratase; Provisional; Region: PRK07509
1127134013914	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1127134013915	substrate binding site [chemical binding]; other site
1127134013916	oxyanion hole (OAH) forming residues; other site
1127134013917	trimer interface [polypeptide binding]; other site
1127134013918	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1127134013919	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1127134013920	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134013921	S-adenosylmethionine binding site [chemical binding]; other site
1127134013922	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1127134013923	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1127134013924	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1127134013925	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1127134013926	FAD binding site [chemical binding]; other site
1127134013927	substrate binding site [chemical binding]; other site
1127134013928	catalytic residues [active]
1127134013929	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1127134013930	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1127134013931	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134013932	non-specific DNA binding site [nucleotide binding]; other site
1127134013933	salt bridge; other site
1127134013934	sequence-specific DNA binding site [nucleotide binding]; other site
1127134013935	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
1127134013936	VanW like protein; Region: VanW; pfam04294
1127134013937	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1127134013938	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134013939	Secretory lipase; Region: LIP; pfam03583
1127134013940	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134013941	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1127134013942	RibD C-terminal domain; Region: RibD_C; cl17279
1127134013943	acetyl-CoA acetyltransferase; Provisional; Region: PRK09268
1127134013944	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1127134013945	dimer interface [polypeptide binding]; other site
1127134013946	active site
1127134013947	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261
1127134013948	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134013949	NAD(P) binding site [chemical binding]; other site
1127134013950	active site
1127134013951	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134013952	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1127134013953	active site 2 [active]
1127134013954	active site 1 [active]
1127134013955	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134013956	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134013957	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1127134013958	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1127134013959	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1127134013960	Ligand Binding Site [chemical binding]; other site
1127134013961	isochorismate synthase DhbC; Validated; Region: PRK06923
1127134013962	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1127134013963	Protein of unknown function (DUF2613); Region: DUF2613; pfam11021
1127134013964	Domain of unknown function (DUF3367); Region: DUF3367; pfam11847
1127134013965	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1127134013966	Protein of unknown function (DUF3068); Region: DUF3068; pfam11271
1127134013967	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1127134013968	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1127134013969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134013970	S-adenosylmethionine binding site [chemical binding]; other site
1127134013971	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
1127134013972	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1127134013973	NAD binding site [chemical binding]; other site
1127134013974	catalytic residues [active]
1127134013975	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
1127134013976	active site
1127134013977	substrate-binding site [chemical binding]; other site
1127134013978	metal-binding site [ion binding]
1127134013979	GTP binding site [chemical binding]; other site
1127134013980	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1127134013981	G3 box; other site
1127134013982	Switch II region; other site
1127134013983	G4 box; other site
1127134013984	short chain dehydrogenase; Provisional; Region: PRK08267
1127134013985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134013986	NAD(P) binding site [chemical binding]; other site
1127134013987	active site
1127134013988	Secretory lipase; Region: LIP; pfam03583
1127134013989	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134013990	LabA_like proteins; Region: LabA_like; cd06167
1127134013991	putative metal binding site [ion binding]; other site
1127134013992	MMPL family; Region: MMPL; pfam03176
1127134013993	Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616
1127134013994	putative heme binding sites [chemical binding]; other site
1127134013995	MMPL family; Region: MMPL; pfam03176
1127134013996	Prion/Doppel alpha-helical domain; Region: Prion; cl02493
1127134013997	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1127134013998	putative active site [active]
1127134013999	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1127134014000	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134014001	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1127134014002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1127134014003	active site
1127134014004	phosphorylation site [posttranslational modification]
1127134014005	intermolecular recognition site; other site
1127134014006	dimerization interface [polypeptide binding]; other site
1127134014007	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1127134014008	DNA binding residues [nucleotide binding]
1127134014009	dimerization interface [polypeptide binding]; other site
1127134014010	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1127134014011	Mg2+ binding site [ion binding]; other site
1127134014012	G-X-G motif; other site
1127134014013	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1127134014014	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1127134014015	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1127134014016	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1127134014017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1127134014018	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134014019	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1127134014020	NAD(P) binding site [chemical binding]; other site
1127134014021	active site
1127134014022	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1127134014023	dimerization interface [polypeptide binding]; other site
1127134014024	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1127134014025	cyclase homology domain; Region: CHD; cd07302
1127134014026	nucleotidyl binding site; other site
1127134014027	metal binding site [ion binding]; metal-binding site
1127134014028	dimer interface [polypeptide binding]; other site
1127134014029	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1127134014030	Predicted integral membrane protein [Function unknown]; Region: COG0392
1127134014031	Protein of unknown function (DUF3054); Region: DUF3054; pfam11255
1127134014032	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
1127134014033	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1127134014034	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1127134014035	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1127134014036	trimer interface [polypeptide binding]; other site
1127134014037	active site
1127134014038	dimer interface [polypeptide binding]; other site
1127134014039	Domain of unknown function (DUF385); Region: DUF385; cl04387
1127134014040	Predicted membrane protein [Function unknown]; Region: COG2860
1127134014041	UPF0126 domain; Region: UPF0126; pfam03458
1127134014042	UPF0126 domain; Region: UPF0126; pfam03458
1127134014043	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134014044	dimerization interface [polypeptide binding]; other site
1127134014045	putative DNA binding site [nucleotide binding]; other site
1127134014046	putative Zn2+ binding site [ion binding]; other site
1127134014047	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1127134014048	putative hydrophobic ligand binding site [chemical binding]; other site
1127134014049	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1127134014050	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1127134014051	Walker A/P-loop; other site
1127134014052	ATP binding site [chemical binding]; other site
1127134014053	Q-loop/lid; other site
1127134014054	ABC transporter signature motif; other site
1127134014055	Walker B; other site
1127134014056	D-loop; other site
1127134014057	H-loop/switch region; other site
1127134014058	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134014059	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134014060	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134014061	salt bridge; other site
1127134014062	non-specific DNA binding site [nucleotide binding]; other site
1127134014063	sequence-specific DNA binding site [nucleotide binding]; other site
1127134014064	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1127134014065	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1127134014066	Predicted transcriptional regulators [Transcription]; Region: COG1733
1127134014067	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1127134014068	Glycerate kinase family; Region: Gly_kinase; cl00841
1127134014069	Predicted acetyltransferase [General function prediction only]; Region: COG2388
1127134014070	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1127134014071	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1127134014072	putative acyl-acceptor binding pocket; other site
1127134014073	hypothetical protein; Validated; Region: PRK00228
1127134014074	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1127134014075	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1127134014076	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134014077	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1127134014078	Walker A/P-loop; other site
1127134014079	ATP binding site [chemical binding]; other site
1127134014080	Q-loop/lid; other site
1127134014081	ABC transporter signature motif; other site
1127134014082	Walker B; other site
1127134014083	D-loop; other site
1127134014084	H-loop/switch region; other site
1127134014085	EXLDI protein; Region: EXLDI; TIGR04342
1127134014086	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1127134014087	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1127134014088	PYR/PP interface [polypeptide binding]; other site
1127134014089	dimer interface [polypeptide binding]; other site
1127134014090	TPP binding site [chemical binding]; other site
1127134014091	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1127134014092	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1127134014093	TPP-binding site [chemical binding]; other site
1127134014094	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134014095	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
1127134014096	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1127134014097	active site
1127134014098	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1127134014099	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
1127134014100	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1127134014101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1127134014102	homodimer interface [polypeptide binding]; other site
1127134014103	catalytic residue [active]
1127134014104	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1127134014105	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134014106	NAD(P) binding site [chemical binding]; other site
1127134014107	active site
1127134014108	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134014109	non-specific DNA binding site [nucleotide binding]; other site
1127134014110	salt bridge; other site
1127134014111	sequence-specific DNA binding site [nucleotide binding]; other site
1127134014112	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134014113	Protein of unknown function (DUF3558); Region: DUF3558; pfam12079
1127134014114	EspG family; Region: ESX-1_EspG; pfam14011
1127134014115	RHS Repeat; Region: RHS_repeat; cl11982
1127134014116	RHS Repeat; Region: RHS_repeat; cl11982
1127134014117	RHS Repeat; Region: RHS_repeat; pfam05593
1127134014118	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
1127134014119	RHS Repeat; Region: RHS_repeat; pfam05593
1127134014120	RHS Repeat; Region: RHS_repeat; pfam05593
1127134014121	RHS Repeat; Region: RHS_repeat; pfam05593
1127134014122	RHS Repeat; Region: RHS_repeat; pfam05593
1127134014123	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
1127134014124	hypothetical protein; Provisional; Region: PRK05409
1127134014125	TIGR04222 domain; Region: near_uncomplex
1127134014126	TIGR04222 domain; Region: near_uncomplex
1127134014127	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1127134014128	short chain dehydrogenase; Provisional; Region: PRK08219
1127134014129	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134014130	NAD(P) binding site [chemical binding]; other site
1127134014131	active site
1127134014132	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1127134014133	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1127134014134	NodB motif; other site
1127134014135	active site
1127134014136	catalytic site [active]
1127134014137	metal binding site [ion binding]; metal-binding site
1127134014138	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1127134014139	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134014140	active site
1127134014141	HIGH motif; other site
1127134014142	nucleotide binding site [chemical binding]; other site
1127134014143	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1127134014144	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134014145	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1127134014146	active site
1127134014147	KMSKS motif; other site
1127134014148	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1127134014149	tRNA binding surface [nucleotide binding]; other site
1127134014150	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
1127134014151	active site
1127134014152	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1127134014153	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1127134014154	Helix-turn-helix domain; Region: HTH_19; pfam12844
1127134014155	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1127134014156	Domain of unknown function (DUF385); Region: DUF385; pfam04075
1127134014157	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1127134014158	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1127134014159	Walker A/P-loop; other site
1127134014160	ATP binding site [chemical binding]; other site
1127134014161	Q-loop/lid; other site
1127134014162	ABC transporter signature motif; other site
1127134014163	Walker B; other site
1127134014164	D-loop; other site
1127134014165	H-loop/switch region; other site
1127134014166	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1127134014167	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1127134014168	substrate binding pocket [chemical binding]; other site
1127134014169	membrane-bound complex binding site; other site
1127134014170	hinge residues; other site
1127134014171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134014172	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1127134014173	dimer interface [polypeptide binding]; other site
1127134014174	conserved gate region; other site
1127134014175	putative PBP binding loops; other site
1127134014176	ABC-ATPase subunit interface; other site
1127134014177	probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856
1127134014178	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995
1127134014179	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1127134014180	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1127134014181	Walker A/P-loop; other site
1127134014182	ATP binding site [chemical binding]; other site
1127134014183	Q-loop/lid; other site
1127134014184	ABC transporter signature motif; other site
1127134014185	Walker B; other site
1127134014186	D-loop; other site
1127134014187	H-loop/switch region; other site
1127134014188	TOBE domain; Region: TOBE_2; pfam08402
1127134014189	O-succinylbenzoate synthase; Provisional; Region: PRK02901
1127134014190	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1127134014191	active site
1127134014192	putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185
1127134014193	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1127134014194	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1127134014195	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134014196	dimer interface [polypeptide binding]; other site
1127134014197	conserved gate region; other site
1127134014198	putative PBP binding loops; other site
1127134014199	ABC-ATPase subunit interface; other site
1127134014200	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1127134014201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1127134014202	dimer interface [polypeptide binding]; other site
1127134014203	conserved gate region; other site
1127134014204	putative PBP binding loops; other site
1127134014205	ABC-ATPase subunit interface; other site
1127134014206	Transglycosylase; Region: Transgly; pfam00912
1127134014207	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1127134014208	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1127134014209	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1127134014210	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1127134014211	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
1127134014212	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
1127134014213	Predicted transcriptional regulators [Transcription]; Region: COG1695
1127134014214	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1127134014215	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134014216	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134014217	Domain of unknown function (DUF1707); Region: DUF1707; pfam08044
1127134014218	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1127134014219	Transglycosylase; Region: Transgly; pfam00912
1127134014220	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1127134014221	Predicted integral membrane protein [Function unknown]; Region: COG5650
1127134014222	Predicted integral membrane protein [Function unknown]; Region: COG5650
1127134014223	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134014224	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134014225	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134014226	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134014227	putative metal binding site [ion binding]; other site
1127134014228	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134014229	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134014230	putative metal binding site [ion binding]; other site
1127134014231	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1127134014232	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
1127134014233	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1127134014234	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1127134014235	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1127134014236	FMN binding site [chemical binding]; other site
1127134014237	active site
1127134014238	substrate binding site [chemical binding]; other site
1127134014239	catalytic residue [active]
1127134014240	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1127134014241	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1127134014242	DNA binding residues [nucleotide binding]
1127134014243	putative dimer interface [polypeptide binding]; other site
1127134014244	HTH domain; Region: HTH_11; pfam08279
1127134014245	WYL domain; Region: WYL; pfam13280
1127134014246	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1127134014247	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1127134014248	active site
1127134014249	Protein of unknown function (DUF3706); Region: DUF3706; pfam12500
1127134014250	Protein of unknown function (DUF2983); Region: DUF2983; pfam11202
1127134014251	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
1127134014252	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1127134014253	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134014254	putative metal binding site [ion binding]; other site
1127134014255	hypothetical protein; Provisional; Region: PRK14013
1127134014256	Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110
1127134014257	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1127134014258	putative metal binding site [ion binding]; other site
1127134014259	Domain of unknown function (DUF389); Region: DUF389; pfam04087
1127134014260	Secretory lipase; Region: LIP; pfam03583
1127134014261	Cutinase; Region: Cutinase; pfam01083
1127134014262	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1127134014263	replicative DNA helicase; Region: DnaB; TIGR00665
1127134014264	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1127134014265	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1127134014266	Walker A motif; other site
1127134014267	ATP binding site [chemical binding]; other site
1127134014268	Walker B motif; other site
1127134014269	DNA binding loops [nucleotide binding]
1127134014270	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1127134014271	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1127134014272	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1127134014273	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1127134014274	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1127134014275	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1127134014276	dimer interface [polypeptide binding]; other site
1127134014277	ssDNA binding site [nucleotide binding]; other site
1127134014278	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1127134014279	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1127134014280	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1127134014281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1127134014282	S-adenosylmethionine binding site [chemical binding]; other site
1127134014283	Nitronate monooxygenase; Region: NMO; pfam03060
1127134014284	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134014285	FMN binding site [chemical binding]; other site
1127134014286	substrate binding site [chemical binding]; other site
1127134014287	putative catalytic residue [active]
1127134014288	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1127134014289	DNA-binding site [nucleotide binding]; DNA binding site
1127134014290	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1127134014291	ABC1 family; Region: ABC1; cl17513
1127134014292	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1127134014293	active site
1127134014294	ATP binding site [chemical binding]; other site
1127134014295	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1127134014296	active site
1127134014297	catalytic triad [active]
1127134014298	oxyanion hole [active]
1127134014299	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
1127134014300	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1127134014301	classical (c) SDRs; Region: SDR_c; cd05233
1127134014302	NAD(P) binding site [chemical binding]; other site
1127134014303	active site
1127134014304	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1127134014305	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786
1127134014306	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1127134014307	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
1127134014308	acyl-activating enzyme (AAE) consensus motif; other site
1127134014309	acyl-activating enzyme (AAE) consensus motif; other site
1127134014310	putative AMP binding site [chemical binding]; other site
1127134014311	putative active site [active]
1127134014312	putative CoA binding site [chemical binding]; other site
1127134014313	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1127134014314	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1127134014315	FMN binding site [chemical binding]; other site
1127134014316	substrate binding site [chemical binding]; other site
1127134014317	putative catalytic residue [active]
1127134014318	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1127134014319	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1127134014320	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1127134014321	active site
1127134014322	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1127134014323	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1127134014324	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1127134014325	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1127134014326	KR domain; Region: KR; pfam08659
1127134014327	NAD(P) binding site [chemical binding]; other site
1127134014328	active site
1127134014329	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1127134014330	acyl-CoA synthetase; Validated; Region: PRK05850
1127134014331	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1127134014332	acyl-activating enzyme (AAE) consensus motif; other site
1127134014333	active site
1127134014334	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1127134014335	RNA binding surface [nucleotide binding]; other site
1127134014336	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1127134014337	NlpC/P60 family; Region: NLPC_P60; cl17555
1127134014338	AAA ATPase domain; Region: AAA_16; pfam13191
1127134014339	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1127134014340	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1127134014341	active site
1127134014342	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1127134014343	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1127134014344	TAP-like protein; Region: Abhydrolase_4; pfam08386
1127134014345	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803
1127134014346	L-aspartate oxidase; Provisional; Region: PRK06175
1127134014347	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1127134014348	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386
1127134014349	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1127134014350	catalytic loop [active]
1127134014351	iron binding site [ion binding]; other site
1127134014352	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134014353	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1127134014354	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134014355	non-specific DNA binding site [nucleotide binding]; other site
1127134014356	salt bridge; other site
1127134014357	sequence-specific DNA binding site [nucleotide binding]; other site
1127134014358	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1127134014359	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1127134014360	minor groove reading motif; other site
1127134014361	helix-hairpin-helix signature motif; other site
1127134014362	active site
1127134014363	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1127134014364	FAD binding domain; Region: FAD_binding_4; pfam01565
1127134014365	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
1127134014366	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
1127134014367	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1127134014368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1127134014369	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1127134014370	Walker A/P-loop; other site
1127134014371	ATP binding site [chemical binding]; other site
1127134014372	Q-loop/lid; other site
1127134014373	ABC transporter signature motif; other site
1127134014374	Walker B; other site
1127134014375	D-loop; other site
1127134014376	H-loop/switch region; other site
1127134014377	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1127134014378	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1127134014379	NADP binding site [chemical binding]; other site
1127134014380	dimer interface [polypeptide binding]; other site
1127134014381	DNA polymerase IV; Validated; Region: PRK03352
1127134014382	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1127134014383	active site
1127134014384	DNA binding site [nucleotide binding]
1127134014385	PemK-like protein; Region: PemK; pfam02452
1127134014386	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1127134014387	CoenzymeA binding site [chemical binding]; other site
1127134014388	subunit interaction site [polypeptide binding]; other site
1127134014389	PHB binding site; other site
1127134014390	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1127134014391	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1127134014392	ATP binding site [chemical binding]; other site
1127134014393	Walker B motif; other site
1127134014394	arginine finger; other site
1127134014395	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1127134014396	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1127134014397	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1127134014398	dimerization interface [polypeptide binding]; other site
1127134014399	putative DNA binding site [nucleotide binding]; other site
1127134014400	putative Zn2+ binding site [ion binding]; other site
1127134014401	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1127134014402	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1127134014403	putative active site [active]
1127134014404	TIGR03084 family protein; Region: TIGR03084
1127134014405	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1127134014406	Wyosine base formation; Region: Wyosine_form; pfam08608
1127134014407	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1127134014408	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1127134014409	hypothetical protein; Provisional; Region: PRK07233
1127134014410	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1127134014411	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1127134014412	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1127134014413	hydrophobic ligand binding site; other site
1127134014414	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1127134014415	active site
1127134014416	RNA/DNA hybrid binding site [nucleotide binding]; other site
1127134014417	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134014418	mce related protein; Region: MCE; pfam02470
1127134014419	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134014420	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134014421	mce related protein; Region: MCE; pfam02470
1127134014422	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134014423	mce related protein; Region: MCE; pfam02470
1127134014424	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134014425	mce related protein; Region: MCE; pfam02470
1127134014426	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134014427	mce related protein; Region: MCE; pfam02470
1127134014428	virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996
1127134014429	mce related protein; Region: MCE; pfam02470
1127134014430	Protein of unknown function (DUF3407); Region: DUF3407; pfam11887
1127134014431	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134014432	Permease; Region: Permease; pfam02405
1127134014433	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1127134014434	Permease; Region: Permease; pfam02405
1127134014435	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1127134014436	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1127134014437	Beta-lactamase; Region: Beta-lactamase; pfam00144
1127134014438	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1127134014439	Cytochrome P450; Region: p450; cl12078
1127134014440	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1127134014441	IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432
1127134014442	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1127134014443	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1127134014444	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1127134014445	active site
1127134014446	Zn binding site [ion binding]; other site
1127134014447	Domain of unknown function (DUF397); Region: DUF397; pfam04149
1127134014448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1127134014449	non-specific DNA binding site [nucleotide binding]; other site
1127134014450	salt bridge; other site
1127134014451	sequence-specific DNA binding site [nucleotide binding]; other site
1127134014452	Pirin; Region: Pirin; pfam02678
1127134014453	Pirin-related protein [General function prediction only]; Region: COG1741
1127134014454	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1127134014455	active site
1127134014456	8-oxo-dGMP binding site [chemical binding]; other site
1127134014457	nudix motif; other site
1127134014458	metal binding site [ion binding]; metal-binding site
1127134014459	Domain of unknown function (DUF4185); Region: DUF4185; pfam13810
1127134014460	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
1127134014461	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1127134014462	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1127134014463	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1127134014464	putative active site [active]
1127134014465	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
1127134014466	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1127134014467	active site
1127134014468	NTP binding site [chemical binding]; other site
1127134014469	metal binding triad [ion binding]; metal-binding site
1127134014470	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1127134014471	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1127134014472	Zn2+ binding site [ion binding]; other site
1127134014473	Mg2+ binding site [ion binding]; other site
1127134014474	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1127134014475	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1127134014476	active site
1127134014477	Ap6A binding site [chemical binding]; other site
1127134014478	nudix motif; other site
1127134014479	metal binding site [ion binding]; metal-binding site
1127134014480	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1127134014481	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1127134014482	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1127134014483	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1127134014484	DNA binding residues [nucleotide binding]
1127134014485	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1127134014486	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1127134014487	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1127134014488	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1127134014489	catalytic residues [active]
1127134014490	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1127134014491	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1127134014492	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1127134014493	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1127134014494	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1127134014495	active site
1127134014496	metal binding site [ion binding]; metal-binding site
1127134014497	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1127134014498	ParB-like nuclease domain; Region: ParBc; pfam02195
1127134014499	KorB domain; Region: KorB; pfam08535
1127134014500	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1127134014501	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1127134014502	P-loop; other site
1127134014503	Magnesium ion binding site [ion binding]; other site
1127134014504	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1127134014505	Magnesium ion binding site [ion binding]; other site
1127134014506	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1127134014507	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1127134014508	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1127134014509	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1127134014510	G-X-X-G motif; other site
1127134014511	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1127134014512	RxxxH motif; other site
1127134014513	putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449
1127134014514	hypothetical protein; Validated; Region: PRK00041
1127134014515	Ribonuclease P; Region: Ribonuclease_P; cl00457