-- dump date 20140619_163714 -- class Genbank::misc_feature -- table misc_feature_note -- id note 935589000001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 935589000002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935589000003 Coenzyme A binding pocket [chemical binding]; other site 935589000004 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 935589000005 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 935589000006 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935589000007 active site 935589000008 HIGH motif; other site 935589000009 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 935589000010 active site 935589000011 KMSKS motif; other site 935589000012 Uncharacterized conserved protein [Function unknown]; Region: COG1434 935589000013 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 935589000014 putative active site [active] 935589000015 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 935589000016 ArsC family; Region: ArsC; pfam03960 935589000017 catalytic residues [active] 935589000018 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935589000019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935589000020 catalytic residues [active] 935589000021 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 935589000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589000023 Walker A/P-loop; other site 935589000024 ATP binding site [chemical binding]; other site 935589000025 Q-loop/lid; other site 935589000026 ABC transporter signature motif; other site 935589000027 Walker B; other site 935589000028 D-loop; other site 935589000029 H-loop/switch region; other site 935589000030 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 935589000031 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 935589000032 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 935589000033 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 935589000034 Phosphoglycerate kinase; Region: PGK; pfam00162 935589000035 substrate binding site [chemical binding]; other site 935589000036 hinge regions; other site 935589000037 ADP binding site [chemical binding]; other site 935589000038 catalytic site [active] 935589000039 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589000040 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589000041 Homeodomain-like domain; Region: HTH_32; pfam13565 935589000042 Integrase core domain; Region: rve; pfam00665 935589000043 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 935589000044 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 935589000045 hinge; other site 935589000046 active site 935589000047 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 935589000048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 935589000049 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 935589000050 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 935589000051 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 935589000052 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 935589000053 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935589000054 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 935589000055 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 935589000056 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 935589000057 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 935589000058 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000059 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000060 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000061 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000062 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000063 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000064 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000065 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000066 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000067 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000068 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000069 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000070 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000071 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000072 Pilin (bacterial filament); Region: Pilin; pfam00114 935589000073 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589000074 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 935589000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935589000076 Predicted membrane protein [Function unknown]; Region: COG3205 935589000077 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 935589000078 glycerate dehydrogenase; Provisional; Region: PRK06487 935589000079 putative ligand binding site [chemical binding]; other site 935589000080 putative NAD binding site [chemical binding]; other site 935589000081 catalytic site [active] 935589000082 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 935589000083 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 935589000084 active site 935589000085 HIGH motif; other site 935589000086 KMSKS motif; other site 935589000087 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 935589000088 tRNA binding surface [nucleotide binding]; other site 935589000089 anticodon binding site; other site 935589000090 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 935589000091 dimer interface [polypeptide binding]; other site 935589000092 putative tRNA-binding site [nucleotide binding]; other site 935589000093 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 935589000094 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 935589000095 glutaminase active site [active] 935589000096 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 935589000097 dimer interface [polypeptide binding]; other site 935589000098 active site 935589000099 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 935589000100 dimer interface [polypeptide binding]; other site 935589000101 active site 935589000102 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 935589000103 MltA specific insert domain; Region: MltA; pfam03562 935589000104 3D domain; Region: 3D; pfam06725 935589000105 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 935589000106 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 935589000107 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 935589000108 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 935589000109 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 935589000110 PhnA protein; Region: PhnA; pfam03831 935589000111 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: glmU; TIGR01173 935589000112 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 935589000113 Substrate binding site; other site 935589000114 Mg++ binding site; other site 935589000115 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 935589000116 active site 935589000117 substrate binding site [chemical binding]; other site 935589000118 CoA binding site [chemical binding]; other site 935589000119 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 935589000120 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935589000121 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935589000122 Conserved TM helix; Region: TM_helix; pfam05552 935589000123 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935589000124 Competence-damaged protein; Region: CinA; pfam02464 935589000125 trifunctional thioredoxin/methionine sulfoxide reductase A/B protein; Provisional; Region: PRK14018 935589000126 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935589000127 catalytic residues [active] 935589000128 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 935589000129 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 935589000130 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 935589000131 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 935589000132 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935589000133 P loop; other site 935589000134 GTP binding site [chemical binding]; other site 935589000135 TIGR01666 family membrane protein; Region: YCCS 935589000136 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 935589000137 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 935589000138 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 935589000139 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 935589000140 Walker A motif; other site 935589000141 ATP binding site [chemical binding]; other site 935589000142 Walker B motif; other site 935589000143 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 935589000144 SPOC domain; Region: SPOC; pfam07744 935589000145 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 935589000146 Walker A motif; other site 935589000147 ATP binding site [chemical binding]; other site 935589000148 Walker B motif; other site 935589000149 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 935589000150 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935589000151 catalytic residue [active] 935589000152 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 935589000153 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 935589000154 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 935589000155 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 935589000156 Helix-hairpin-helix motif; Region: HHH; pfam00633 935589000157 chaperone protein DnaJ; Provisional; Region: PRK10767 935589000158 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935589000159 HSP70 interaction site [polypeptide binding]; other site 935589000160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 935589000161 substrate binding site [polypeptide binding]; other site 935589000162 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 935589000163 Zn binding sites [ion binding]; other site 935589000164 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 935589000165 dimer interface [polypeptide binding]; other site 935589000166 Predicted membrane protein [Function unknown]; Region: COG1297 935589000167 putative oligopeptide transporter, OPT family; Region: TIGR00733 935589000168 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 935589000169 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935589000170 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935589000171 substrate binding site; other site 935589000172 tetramer interface; other site 935589000173 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935589000174 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 935589000175 NAD binding site [chemical binding]; other site 935589000176 substrate binding site [chemical binding]; other site 935589000177 homodimer interface [polypeptide binding]; other site 935589000178 active site 935589000179 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 935589000180 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 935589000181 NAD binding site [chemical binding]; other site 935589000182 homodimer interface [polypeptide binding]; other site 935589000183 active site 935589000184 substrate binding site [chemical binding]; other site 935589000185 Transposase domain (DUF772); Region: DUF772; pfam05598 935589000186 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589000187 DDE superfamily endonuclease; Region: DDE_4; cl17710 935589000188 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 935589000189 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 935589000190 NeuB family; Region: NeuB; pfam03102 935589000191 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 935589000192 NeuB binding interface [polypeptide binding]; other site 935589000193 putative substrate binding site [chemical binding]; other site 935589000194 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 935589000195 ligand binding site; other site 935589000196 tetramer interface; other site 935589000197 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 935589000198 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 935589000199 active site 935589000200 homodimer interface [polypeptide binding]; other site 935589000201 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 935589000202 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 935589000203 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 935589000204 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 935589000205 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 935589000206 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 935589000207 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 935589000208 Walker A/P-loop; other site 935589000209 ATP binding site [chemical binding]; other site 935589000210 Q-loop/lid; other site 935589000211 ABC transporter signature motif; other site 935589000212 Walker B; other site 935589000213 D-loop; other site 935589000214 H-loop/switch region; other site 935589000215 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 935589000216 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 935589000217 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 935589000218 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 935589000219 RNA binding site [nucleotide binding]; other site 935589000220 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 935589000221 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 935589000222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935589000223 active site 935589000224 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 935589000225 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 935589000226 NAD binding site [chemical binding]; other site 935589000227 substrate binding site [chemical binding]; other site 935589000228 homodimer interface [polypeptide binding]; other site 935589000229 active site 935589000230 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 935589000231 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 935589000232 substrate binding site; other site 935589000233 tetramer interface; other site 935589000234 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 935589000235 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 935589000236 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 935589000237 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 935589000238 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935589000239 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935589000240 Sel1-like repeats; Region: SEL1; smart00671 935589000241 Sel1-like repeats; Region: SEL1; smart00671 935589000242 Sel1-like repeats; Region: SEL1; smart00671 935589000243 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 935589000244 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 935589000245 cyanate hydratase; Validated; Region: PRK02866 935589000246 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 935589000247 pyruvate kinase; Provisional; Region: PRK05826 935589000248 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 935589000249 domain interfaces; other site 935589000250 active site 935589000251 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 935589000252 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 935589000253 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935589000254 HlyD family secretion protein; Region: HlyD_3; pfam13437 935589000255 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 935589000256 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 935589000257 putative active site [active] 935589000258 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935589000259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589000260 Walker A/P-loop; other site 935589000261 ATP binding site [chemical binding]; other site 935589000262 Q-loop/lid; other site 935589000263 ABC transporter signature motif; other site 935589000264 Walker B; other site 935589000265 D-loop; other site 935589000266 H-loop/switch region; other site 935589000267 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 935589000268 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 935589000269 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 935589000270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935589000271 Coenzyme A binding pocket [chemical binding]; other site 935589000272 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 935589000273 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935589000274 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935589000275 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 935589000276 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 935589000277 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 935589000278 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935589000279 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 935589000280 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 935589000281 active site 935589000282 catalytic residues [active] 935589000283 metal binding site [ion binding]; metal-binding site 935589000284 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 935589000285 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 935589000286 putative active site [active] 935589000287 substrate binding site [chemical binding]; other site 935589000288 putative cosubstrate binding site; other site 935589000289 catalytic site [active] 935589000290 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 935589000291 substrate binding site [chemical binding]; other site 935589000292 16S rRNA methyltransferase B; Provisional; Region: PRK10901 935589000293 NusB family; Region: NusB; pfam01029 935589000294 putative RNA binding site [nucleotide binding]; other site 935589000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589000296 S-adenosylmethionine binding site [chemical binding]; other site 935589000297 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 935589000298 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 935589000299 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935589000300 dimerization interface [polypeptide binding]; other site 935589000301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935589000302 dimer interface [polypeptide binding]; other site 935589000303 phosphorylation site [posttranslational modification] 935589000304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589000305 ATP binding site [chemical binding]; other site 935589000306 Mg2+ binding site [ion binding]; other site 935589000307 G-X-G motif; other site 935589000308 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 935589000309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935589000310 active site 935589000311 phosphorylation site [posttranslational modification] 935589000312 intermolecular recognition site; other site 935589000313 dimerization interface [polypeptide binding]; other site 935589000314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 935589000315 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 935589000316 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 935589000317 DNA protecting protein DprA; Region: dprA; TIGR00732 935589000318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Smg; COG2922 935589000319 DNA topoisomerase I; Validated; Region: PRK06599 935589000320 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 935589000321 active site 935589000322 interdomain interaction site; other site 935589000323 putative metal-binding site [ion binding]; other site 935589000324 nucleotide binding site [chemical binding]; other site 935589000325 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 935589000326 domain I; other site 935589000327 DNA binding groove [nucleotide binding] 935589000328 phosphate binding site [ion binding]; other site 935589000329 domain II; other site 935589000330 domain III; other site 935589000331 nucleotide binding site [chemical binding]; other site 935589000332 catalytic site [active] 935589000333 domain IV; other site 935589000334 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935589000335 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 935589000336 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935589000337 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 935589000338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 935589000339 sequence-specific DNA binding site [nucleotide binding]; other site 935589000340 salt bridge; other site 935589000341 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 935589000342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589000343 S-adenosylmethionine binding site [chemical binding]; other site 935589000344 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 935589000345 elongation factor Tu; Reviewed; Region: PRK00049 935589000346 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935589000347 G1 box; other site 935589000348 GEF interaction site [polypeptide binding]; other site 935589000349 GTP/Mg2+ binding site [chemical binding]; other site 935589000350 Switch I region; other site 935589000351 G2 box; other site 935589000352 G3 box; other site 935589000353 Switch II region; other site 935589000354 G4 box; other site 935589000355 G5 box; other site 935589000356 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935589000357 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935589000358 Antibiotic Binding Site [chemical binding]; other site 935589000359 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 935589000360 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 935589000361 putative homodimer interface [polypeptide binding]; other site 935589000362 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 935589000363 heterodimer interface [polypeptide binding]; other site 935589000364 homodimer interface [polypeptide binding]; other site 935589000365 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 935589000366 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 935589000367 23S rRNA interface [nucleotide binding]; other site 935589000368 L7/L12 interface [polypeptide binding]; other site 935589000369 putative thiostrepton binding site; other site 935589000370 L25 interface [polypeptide binding]; other site 935589000371 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 935589000372 mRNA/rRNA interface [nucleotide binding]; other site 935589000373 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 935589000374 23S rRNA interface [nucleotide binding]; other site 935589000375 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 935589000376 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 935589000377 core dimer interface [polypeptide binding]; other site 935589000378 peripheral dimer interface [polypeptide binding]; other site 935589000379 L10 interface [polypeptide binding]; other site 935589000380 L11 interface [polypeptide binding]; other site 935589000381 putative EF-Tu interaction site [polypeptide binding]; other site 935589000382 putative EF-G interaction site [polypeptide binding]; other site 935589000383 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 935589000384 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 935589000385 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 935589000386 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935589000387 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 935589000388 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 935589000389 RPB3 interaction site [polypeptide binding]; other site 935589000390 RPB1 interaction site [polypeptide binding]; other site 935589000391 RPB11 interaction site [polypeptide binding]; other site 935589000392 RPB10 interaction site [polypeptide binding]; other site 935589000393 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 935589000394 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 935589000395 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 935589000396 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 935589000397 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 935589000398 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 935589000399 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 935589000400 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 935589000401 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 935589000402 DNA binding site [nucleotide binding] 935589000403 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 935589000404 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935589000405 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 935589000406 S17 interaction site [polypeptide binding]; other site 935589000407 S8 interaction site; other site 935589000408 16S rRNA interaction site [nucleotide binding]; other site 935589000409 streptomycin interaction site [chemical binding]; other site 935589000410 23S rRNA interaction site [nucleotide binding]; other site 935589000411 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 935589000412 30S ribosomal protein S7; Validated; Region: PRK05302 935589000413 elongation factor G; Reviewed; Region: PRK00007 935589000414 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 935589000415 G1 box; other site 935589000416 putative GEF interaction site [polypeptide binding]; other site 935589000417 GTP/Mg2+ binding site [chemical binding]; other site 935589000418 Switch I region; other site 935589000419 G2 box; other site 935589000420 G3 box; other site 935589000421 Switch II region; other site 935589000422 G4 box; other site 935589000423 G5 box; other site 935589000424 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 935589000425 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 935589000426 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 935589000427 elongation factor Tu; Reviewed; Region: PRK00049 935589000428 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 935589000429 G1 box; other site 935589000430 GEF interaction site [polypeptide binding]; other site 935589000431 GTP/Mg2+ binding site [chemical binding]; other site 935589000432 Switch I region; other site 935589000433 G2 box; other site 935589000434 G3 box; other site 935589000435 Switch II region; other site 935589000436 G4 box; other site 935589000437 G5 box; other site 935589000438 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 935589000439 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 935589000440 Antibiotic Binding Site [chemical binding]; other site 935589000441 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 935589000442 Transposase domain (DUF772); Region: DUF772; pfam05598 935589000443 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589000444 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 935589000445 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 935589000446 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 935589000447 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 935589000448 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 935589000449 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 935589000450 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 935589000451 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 935589000452 putative translocon binding site; other site 935589000453 protein-rRNA interface [nucleotide binding]; other site 935589000454 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 935589000455 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 935589000456 G-X-X-G motif; other site 935589000457 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 935589000458 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 935589000459 23S rRNA interface [nucleotide binding]; other site 935589000460 5S rRNA interface [nucleotide binding]; other site 935589000461 putative antibiotic binding site [chemical binding]; other site 935589000462 L25 interface [polypeptide binding]; other site 935589000463 L27 interface [polypeptide binding]; other site 935589000464 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 935589000465 23S rRNA interface [nucleotide binding]; other site 935589000466 putative translocon interaction site; other site 935589000467 signal recognition particle (SRP54) interaction site; other site 935589000468 L23 interface [polypeptide binding]; other site 935589000469 trigger factor interaction site; other site 935589000470 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 935589000471 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 935589000472 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 935589000473 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 935589000474 RNA binding site [nucleotide binding]; other site 935589000475 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 935589000476 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 935589000477 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 935589000478 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 935589000479 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 935589000480 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 935589000481 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935589000482 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 935589000483 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 935589000484 5S rRNA interface [nucleotide binding]; other site 935589000485 23S rRNA interface [nucleotide binding]; other site 935589000486 L5 interface [polypeptide binding]; other site 935589000487 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 935589000488 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 935589000489 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 935589000490 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 935589000491 23S rRNA binding site [nucleotide binding]; other site 935589000492 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 935589000493 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 935589000494 SecY translocase; Region: SecY; pfam00344 935589000495 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 935589000496 rRNA binding site [nucleotide binding]; other site 935589000497 predicted 30S ribosome binding site; other site 935589000498 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 935589000499 30S ribosomal protein S13; Region: bact_S13; TIGR03631 935589000500 30S ribosomal protein S11; Validated; Region: PRK05309 935589000501 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 935589000502 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 935589000503 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589000504 RNA binding surface [nucleotide binding]; other site 935589000505 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 935589000506 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 935589000507 alphaNTD homodimer interface [polypeptide binding]; other site 935589000508 alphaNTD - beta interaction site [polypeptide binding]; other site 935589000509 alphaNTD - beta' interaction site [polypeptide binding]; other site 935589000510 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 935589000511 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 935589000512 septum formation inhibitor; Reviewed; Region: minC; PRK04516 935589000513 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 935589000514 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 935589000515 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 935589000516 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 935589000517 Switch I; other site 935589000518 Switch II; other site 935589000519 cell division topological specificity factor MinE; Provisional; Region: PRK13989 935589000520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935589000521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935589000522 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 935589000523 dimerization interface [polypeptide binding]; other site 935589000524 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 935589000525 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935589000526 HIGH motif; other site 935589000527 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 935589000528 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 935589000529 active site 935589000530 KMSKS motif; other site 935589000531 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 935589000532 tRNA binding surface [nucleotide binding]; other site 935589000533 anticodon binding site; other site 935589000534 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 935589000535 zinc transporter ZupT; Provisional; Region: PRK04201 935589000536 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 935589000537 hydroxyglutarate oxidase; Provisional; Region: PRK11728 935589000538 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935589000539 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935589000540 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 935589000541 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 935589000542 active site 935589000543 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 935589000544 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 935589000545 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 935589000546 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 935589000547 trimer interface [polypeptide binding]; other site 935589000548 active site 935589000549 UDP-GlcNAc binding site [chemical binding]; other site 935589000550 lipid binding site [chemical binding]; lipid-binding site 935589000551 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 935589000552 periplasmic chaperone; Provisional; Region: PRK10780 935589000553 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 935589000554 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935589000555 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935589000556 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935589000557 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935589000558 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 935589000559 Surface antigen; Region: Bac_surface_Ag; pfam01103 935589000560 zinc metallopeptidase RseP; Provisional; Region: PRK10779 935589000561 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 935589000562 active site 935589000563 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935589000564 protein binding site [polypeptide binding]; other site 935589000565 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 935589000566 protein binding site [polypeptide binding]; other site 935589000567 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 935589000568 putative substrate binding region [chemical binding]; other site 935589000569 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 935589000570 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 935589000571 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 935589000572 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 935589000573 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 935589000574 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 935589000575 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 935589000576 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 935589000577 catalytic residue [active] 935589000578 putative FPP diphosphate binding site; other site 935589000579 putative FPP binding hydrophobic cleft; other site 935589000580 dimer interface [polypeptide binding]; other site 935589000581 putative IPP diphosphate binding site; other site 935589000582 ribosome recycling factor; Reviewed; Region: frr; PRK00083 935589000583 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 935589000584 hinge region; other site 935589000585 Predicted membrane protein [Function unknown]; Region: COG1289 935589000586 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 935589000587 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 935589000588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589000589 S-adenosylmethionine binding site [chemical binding]; other site 935589000590 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 935589000591 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935589000592 P-loop; other site 935589000593 Magnesium ion binding site [ion binding]; other site 935589000594 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 935589000595 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 935589000596 Magnesium ion binding site [ion binding]; other site 935589000597 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 935589000598 RNA/DNA hybrid binding site [nucleotide binding]; other site 935589000599 active site 935589000600 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 935589000601 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 935589000602 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 935589000603 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935589000604 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 935589000605 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 935589000606 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 935589000607 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 935589000608 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935589000609 homodimer interface [polypeptide binding]; other site 935589000610 oligonucleotide binding site [chemical binding]; other site 935589000611 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 935589000612 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589000613 RNA binding surface [nucleotide binding]; other site 935589000614 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935589000615 active site 935589000616 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 935589000617 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 935589000618 dihydrodipicolinate reductase; Provisional; Region: PRK00048 935589000619 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 935589000620 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 935589000621 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 935589000622 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 935589000623 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 935589000624 metal binding site 2 [ion binding]; metal-binding site 935589000625 putative DNA binding helix; other site 935589000626 metal binding site 1 [ion binding]; metal-binding site 935589000627 dimer interface [polypeptide binding]; other site 935589000628 structural Zn2+ binding site [ion binding]; other site 935589000629 Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360 935589000630 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 935589000631 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935589000632 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935589000633 ferredoxin; Provisional; Region: PRK08764 935589000634 Putative Fe-S cluster; Region: FeS; cl17515 935589000635 4Fe-4S binding domain; Region: Fer4; pfam00037 935589000636 4Fe-4S binding domain; Region: Fer4; pfam00037 935589000637 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 935589000638 putative cation:proton antiport protein; Provisional; Region: PRK10669 935589000639 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 935589000640 TrkA-N domain; Region: TrkA_N; pfam02254 935589000641 TrkA-C domain; Region: TrkA_C; pfam02080 935589000642 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 935589000643 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 935589000644 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 935589000645 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 935589000646 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 935589000647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589000648 Mg2+ binding site [ion binding]; other site 935589000649 G-X-G motif; other site 935589000650 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935589000651 anchoring element; other site 935589000652 dimer interface [polypeptide binding]; other site 935589000653 ATP binding site [chemical binding]; other site 935589000654 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 935589000655 active site 935589000656 putative metal-binding site [ion binding]; other site 935589000657 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935589000658 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 935589000659 Mechanosensitive ion channel; Region: MS_channel; pfam00924 935589000660 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 935589000661 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 935589000662 active site 935589000663 Zn binding site [ion binding]; other site 935589000664 Predicted membrane protein [Function unknown]; Region: COG1971 935589000665 Domain of unknown function DUF; Region: DUF204; pfam02659 935589000666 Domain of unknown function DUF; Region: DUF204; pfam02659 935589000667 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 935589000668 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 935589000669 tetramer interface [polypeptide binding]; other site 935589000670 heme binding pocket [chemical binding]; other site 935589000671 NADPH binding site [chemical binding]; other site 935589000672 DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog [Transcription]; Region: RpoN; COG1508 935589000673 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 935589000674 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 935589000675 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 935589000676 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 935589000677 dimer interface [polypeptide binding]; other site 935589000678 active site 935589000679 acyl carrier protein; Provisional; Region: acpP; PRK00982 935589000680 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 935589000681 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 935589000682 quinone interaction residues [chemical binding]; other site 935589000683 active site 935589000684 catalytic residues [active] 935589000685 FMN binding site [chemical binding]; other site 935589000686 substrate binding site [chemical binding]; other site 935589000687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4304 935589000688 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 935589000689 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935589000690 metal binding triad; other site 935589000691 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935589000692 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935589000693 metal binding triad; other site 935589000694 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589000695 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589000696 Homeodomain-like domain; Region: HTH_32; pfam13565 935589000697 Integrase core domain; Region: rve; pfam00665 935589000698 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 935589000699 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 935589000700 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 935589000701 putative active site [active] 935589000702 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 935589000703 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 935589000704 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 935589000705 DNA helicase II; Region: uvrD; TIGR01075 935589000706 Part of AAA domain; Region: AAA_19; pfam13245 935589000707 Family description; Region: UvrD_C_2; pfam13538 935589000708 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 935589000709 spermidine synthase; Provisional; Region: PRK03612 935589000710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589000711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589000712 S-adenosylmethionine binding site [chemical binding]; other site 935589000713 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 935589000714 NADH dehydrogenase subunit B; Validated; Region: PRK06411 935589000715 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 935589000716 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 935589000717 NADH dehydrogenase subunit D; Validated; Region: PRK06075 935589000718 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 935589000719 NADH dehydrogenase subunit E; Validated; Region: PRK07539 935589000720 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 935589000721 putative dimer interface [polypeptide binding]; other site 935589000722 [2Fe-2S] cluster binding site [ion binding]; other site 935589000723 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 935589000724 SLBB domain; Region: SLBB; pfam10531 935589000725 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 935589000726 NADH dehydrogenase subunit G; Validated; Region: PRK09129 935589000727 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935589000728 catalytic loop [active] 935589000729 iron binding site [ion binding]; other site 935589000730 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 935589000731 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 935589000732 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 935589000733 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 935589000734 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 935589000735 4Fe-4S binding domain; Region: Fer4; cl02805 935589000736 4Fe-4S binding domain; Region: Fer4; pfam00037 935589000737 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 935589000738 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 935589000739 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 935589000740 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 935589000741 Fic/DOC family; Region: Fic; pfam02661 935589000742 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 935589000743 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 935589000744 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935589000745 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 935589000746 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935589000747 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 935589000748 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 935589000749 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 935589000750 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935589000751 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935589000752 substrate binding pocket [chemical binding]; other site 935589000753 chain length determination region; other site 935589000754 substrate-Mg2+ binding site; other site 935589000755 catalytic residues [active] 935589000756 aspartate-rich region 1; other site 935589000757 active site lid residues [active] 935589000758 aspartate-rich region 2; other site 935589000759 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 935589000760 GTPase RsgA; Reviewed; Region: PRK00098 935589000761 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 935589000762 RNA binding site [nucleotide binding]; other site 935589000763 homodimer interface [polypeptide binding]; other site 935589000764 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 935589000765 GTPase/Zn-binding domain interface [polypeptide binding]; other site 935589000766 GTP/Mg2+ binding site [chemical binding]; other site 935589000767 G4 box; other site 935589000768 G5 box; other site 935589000769 G1 box; other site 935589000770 Switch I region; other site 935589000771 G2 box; other site 935589000772 G3 box; other site 935589000773 Switch II region; other site 935589000774 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 935589000775 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935589000776 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 935589000777 Walker A/P-loop; other site 935589000778 ATP binding site [chemical binding]; other site 935589000779 Q-loop/lid; other site 935589000780 ABC transporter signature motif; other site 935589000781 Walker B; other site 935589000782 D-loop; other site 935589000783 H-loop/switch region; other site 935589000784 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 935589000785 RuvA N terminal domain; Region: RuvA_N; pfam01330 935589000786 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 935589000787 Predicted membrane protein [Function unknown]; Region: COG3212 935589000788 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 935589000789 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 935589000790 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 935589000791 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 935589000792 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 935589000793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589000794 active site 935589000795 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 935589000796 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 935589000797 TAP-like protein; Region: Abhydrolase_4; pfam08386 935589000798 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 935589000799 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 935589000800 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589000801 ATP binding site [chemical binding]; other site 935589000802 putative Mg++ binding site [ion binding]; other site 935589000803 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935589000804 nucleotide binding region [chemical binding]; other site 935589000805 ATP-binding site [chemical binding]; other site 935589000806 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 935589000807 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935589000808 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935589000809 Helicase and RNase D C-terminal; Region: HRDC; smart00341 935589000810 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 935589000811 active site 935589000812 ribulose/triose binding site [chemical binding]; other site 935589000813 phosphate binding site [ion binding]; other site 935589000814 substrate (anthranilate) binding pocket [chemical binding]; other site 935589000815 product (indole) binding pocket [chemical binding]; other site 935589000816 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 935589000817 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 935589000818 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 935589000819 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935589000820 catalytic residues [active] 935589000821 hinge region; other site 935589000822 alpha helical domain; other site 935589000823 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 935589000824 Phosphotransferase enzyme family; Region: APH; pfam01636 935589000825 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 935589000826 Organic solvent tolerance protein; Region: OstA_C; pfam04453 935589000827 SurA N-terminal domain; Region: SurA_N; pfam09312 935589000828 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 935589000829 Exoribonuclease R [Transcription]; Region: VacB; COG0557 935589000830 RNB domain; Region: RNB; pfam00773 935589000831 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 935589000832 adenylosuccinate lyase; Provisional; Region: PRK09285 935589000833 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 935589000834 tetramer interface [polypeptide binding]; other site 935589000835 active site 935589000836 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 935589000837 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 935589000838 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 935589000839 DEAD_2; Region: DEAD_2; pfam06733 935589000840 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 935589000841 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 935589000842 DNA photolyase; Region: DNA_photolyase; pfam00875 935589000843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935589000844 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935589000845 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 935589000846 putative effector binding pocket; other site 935589000847 dimerization interface [polypeptide binding]; other site 935589000848 Predicted membrane protein [Function unknown]; Region: COG2259 935589000849 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 935589000850 dimer interface [polypeptide binding]; other site 935589000851 FMN binding site [chemical binding]; other site 935589000852 Uncharacterized conserved protein [Function unknown]; Region: COG1432 935589000853 LabA_like proteins; Region: LabA_like; cd06167 935589000854 putative metal binding site [ion binding]; other site 935589000855 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935589000856 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 935589000857 catalytic residues [active] 935589000858 hinge region; other site 935589000859 alpha helical domain; other site 935589000860 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589000861 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589000862 Homeodomain-like domain; Region: HTH_32; pfam13565 935589000863 Integrase core domain; Region: rve; pfam00665 935589000864 signal recognition particle protein; Provisional; Region: PRK10867 935589000865 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 935589000866 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 935589000867 P loop; other site 935589000868 GTP binding site [chemical binding]; other site 935589000869 Signal peptide binding domain; Region: SRP_SPB; pfam02978 935589000870 comEA protein; Region: comE; TIGR01259 935589000871 Helix-hairpin-helix motif; Region: HHH; pfam00633 935589000872 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 935589000873 Transposase domain (DUF772); Region: DUF772; pfam05598 935589000874 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589000875 ScaI restriction endonuclease; Region: RE_ScaI; pfam09569 935589000876 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 935589000877 DNA methylase; Region: N6_N4_Mtase; pfam01555 935589000878 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 935589000879 Helicase associated domain (HA2); Region: HA2; pfam04408 935589000880 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 935589000881 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935589000882 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 935589000883 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 935589000884 Sulfatase; Region: Sulfatase; pfam00884 935589000885 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935589000886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589000887 ATP binding site [chemical binding]; other site 935589000888 putative Mg++ binding site [ion binding]; other site 935589000889 nucleotide binding region [chemical binding]; other site 935589000890 helicase superfamily c-terminal domain; Region: HELICc; smart00490 935589000891 ATP-binding site [chemical binding]; other site 935589000892 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 935589000893 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 935589000894 putative ion selectivity filter; other site 935589000895 putative pore gating glutamate residue; other site 935589000896 putative H+/Cl- coupling transport residue; other site 935589000897 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 935589000898 heterotetramer interface [polypeptide binding]; other site 935589000899 active site pocket [active] 935589000900 cleavage site 935589000901 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 935589000902 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 935589000903 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935589000904 NlpC/P60 family; Region: NLPC_P60; pfam00877 935589000905 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 935589000906 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 935589000907 dimerization interface [polypeptide binding]; other site 935589000908 domain crossover interface; other site 935589000909 redox-dependent activation switch; other site 935589000910 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 935589000911 MgtE intracellular N domain; Region: MgtE_N; smart00924 935589000912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 935589000913 Divalent cation transporter; Region: MgtE; pfam01769 935589000914 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935589000915 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 935589000916 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935589000917 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935589000918 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 935589000919 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 935589000920 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 935589000921 dimerization interface [polypeptide binding]; other site 935589000922 ATP binding site [chemical binding]; other site 935589000923 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 935589000924 dimerization interface [polypeptide binding]; other site 935589000925 ATP binding site [chemical binding]; other site 935589000926 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 935589000927 putative active site [active] 935589000928 catalytic triad [active] 935589000929 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 935589000930 Nitrogen regulatory protein P-II; Region: P-II; smart00938 935589000931 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 935589000932 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 935589000933 Walker A/P-loop; other site 935589000934 ATP binding site [chemical binding]; other site 935589000935 Q-loop/lid; other site 935589000936 ABC transporter signature motif; other site 935589000937 Walker B; other site 935589000938 D-loop; other site 935589000939 H-loop/switch region; other site 935589000940 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 935589000941 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935589000942 ABC-ATPase subunit interface; other site 935589000943 dimer interface [polypeptide binding]; other site 935589000944 putative PBP binding regions; other site 935589000945 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 935589000946 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935589000947 ABC-ATPase subunit interface; other site 935589000948 dimer interface [polypeptide binding]; other site 935589000949 putative PBP binding regions; other site 935589000950 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935589000951 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 935589000952 putative ligand binding residues [chemical binding]; other site 935589000953 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589000954 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 935589000955 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 935589000956 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 935589000957 trmE is a tRNA modification GTPase; Region: trmE; cd04164 935589000958 G1 box; other site 935589000959 GTP/Mg2+ binding site [chemical binding]; other site 935589000960 Switch I region; other site 935589000961 G2 box; other site 935589000962 Switch II region; other site 935589000963 G3 box; other site 935589000964 G4 box; other site 935589000965 G5 box; other site 935589000966 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 935589000967 Predicted membrane protein [Function unknown]; Region: COG5346 935589000968 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 935589000969 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 935589000970 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 935589000971 Autotransporter beta-domain; Region: Autotransporter; pfam03797 935589000972 Transposase domain (DUF772); Region: DUF772; pfam05598 935589000973 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589000974 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935589000975 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935589000976 Fic/DOC family; Region: Fic; pfam02661 935589000977 DNA polymerase I; Provisional; Region: PRK05755 935589000978 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 935589000979 active site 935589000980 metal binding site 1 [ion binding]; metal-binding site 935589000981 putative 5' ssDNA interaction site; other site 935589000982 metal binding site 3; metal-binding site 935589000983 metal binding site 2 [ion binding]; metal-binding site 935589000984 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 935589000985 putative DNA binding site [nucleotide binding]; other site 935589000986 putative metal binding site [ion binding]; other site 935589000987 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 935589000988 active site 935589000989 catalytic site [active] 935589000990 substrate binding site [chemical binding]; other site 935589000991 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 935589000992 active site 935589000993 DNA binding site [nucleotide binding] 935589000994 catalytic site [active] 935589000995 S-ribosylhomocysteinase; Provisional; Region: PRK02260 935589000996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4316 935589000997 conserved hypothetical integral membrane protein; Region: TIGR00698 935589000998 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 935589000999 putative iron binding site [ion binding]; other site 935589001000 diaminopimelate decarboxylase; Region: lysA; TIGR01048 935589001001 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 935589001002 active site 935589001003 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935589001004 substrate binding site [chemical binding]; other site 935589001005 catalytic residues [active] 935589001006 dimer interface [polypeptide binding]; other site 935589001007 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 935589001008 Na2 binding site [ion binding]; other site 935589001009 putative substrate binding site 1 [chemical binding]; other site 935589001010 Na binding site 1 [ion binding]; other site 935589001011 putative substrate binding site 2 [chemical binding]; other site 935589001012 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589001013 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 935589001014 oligomerisation interface [polypeptide binding]; other site 935589001015 mobile loop; other site 935589001016 roof hairpin; other site 935589001017 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 935589001018 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 935589001019 ring oligomerisation interface [polypeptide binding]; other site 935589001020 ATP/Mg binding site [chemical binding]; other site 935589001021 stacking interactions; other site 935589001022 hinge regions; other site 935589001023 Transposase domain (DUF772); Region: DUF772; pfam05598 935589001024 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589001025 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935589001026 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935589001027 aminodeoxychorismate synthase; Provisional; Region: PRK07508 935589001028 chorismate binding enzyme; Region: Chorismate_bind; cl10555 935589001029 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 935589001030 homodimer interface [polypeptide binding]; other site 935589001031 substrate-cofactor binding pocket; other site 935589001032 Aminotransferase class IV; Region: Aminotran_4; pfam01063 935589001033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589001034 catalytic residue [active] 935589001035 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 935589001036 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 935589001037 NAD binding site [chemical binding]; other site 935589001038 catalytic residues [active] 935589001039 substrate binding site [chemical binding]; other site 935589001040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935589001041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 935589001042 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 935589001043 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 935589001044 Walker A/P-loop; other site 935589001045 ATP binding site [chemical binding]; other site 935589001046 Q-loop/lid; other site 935589001047 ABC transporter signature motif; other site 935589001048 Walker B; other site 935589001049 D-loop; other site 935589001050 H-loop/switch region; other site 935589001051 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 935589001052 Permease; Region: Permease; pfam02405 935589001053 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 935589001054 mce related protein; Region: MCE; pfam02470 935589001055 ABC-type transport system involved in resistance to organic solvents, auxiliary component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2D; COG2854 935589001056 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 935589001057 anti sigma factor interaction site; other site 935589001058 regulatory phosphorylation site [posttranslational modification]; other site 935589001059 Surface lipoprotein [Cell envelope biogenesis, outer membrane]; Region: VacJ; COG2853 935589001060 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 935589001061 active site 935589001062 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 935589001063 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935589001064 catalytic residues [active] 935589001065 ribosomal protein L31; Region: L31; TIGR00105 935589001066 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 935589001067 Cadmium resistance transporter; Region: Cad; pfam03596 935589001068 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 935589001069 stringent starvation protein A; Provisional; Region: sspA; PRK09481 935589001070 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 935589001071 C-terminal domain interface [polypeptide binding]; other site 935589001072 putative GSH binding site (G-site) [chemical binding]; other site 935589001073 dimer interface [polypeptide binding]; other site 935589001074 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 935589001075 dimer interface [polypeptide binding]; other site 935589001076 N-terminal domain interface [polypeptide binding]; other site 935589001077 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 935589001078 Uncharacterized conserved protein [Function unknown]; Region: COG1610 935589001079 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 935589001080 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935589001081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935589001082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935589001083 catalytic residue [active] 935589001084 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 935589001085 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 935589001086 Walker A/P-loop; other site 935589001087 ATP binding site [chemical binding]; other site 935589001088 Q-loop/lid; other site 935589001089 ABC transporter signature motif; other site 935589001090 Walker B; other site 935589001091 D-loop; other site 935589001092 H-loop/switch region; other site 935589001093 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 935589001094 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 935589001095 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 935589001096 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 935589001097 Flavoprotein; Region: Flavoprotein; pfam02441 935589001098 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 935589001099 ParB-like nuclease domain; Region: ParBc; pfam02195 935589001100 KorB domain; Region: KorB; pfam08535 935589001101 F0F1-type ATP synthase, subunit I [Energy production and conversion]; Region: AtpI; COG3312 935589001102 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 935589001103 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 935589001104 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 935589001105 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 935589001106 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 935589001107 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 935589001108 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 935589001109 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 935589001110 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935589001111 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 935589001112 beta subunit interaction interface [polypeptide binding]; other site 935589001113 Walker A motif; other site 935589001114 ATP binding site [chemical binding]; other site 935589001115 Walker B motif; other site 935589001116 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935589001117 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 935589001118 core domain interface [polypeptide binding]; other site 935589001119 delta subunit interface [polypeptide binding]; other site 935589001120 epsilon subunit interface [polypeptide binding]; other site 935589001121 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 935589001122 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 935589001123 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 935589001124 alpha subunit interaction interface [polypeptide binding]; other site 935589001125 Walker A motif; other site 935589001126 ATP binding site [chemical binding]; other site 935589001127 Walker B motif; other site 935589001128 inhibitor binding site; inhibition site 935589001129 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 935589001130 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 935589001131 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 935589001132 gamma subunit interface [polypeptide binding]; other site 935589001133 epsilon subunit interface [polypeptide binding]; other site 935589001134 LBP interface [polypeptide binding]; other site 935589001135 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 935589001136 dimer interface [polypeptide binding]; other site 935589001137 motif 1; other site 935589001138 active site 935589001139 motif 2; other site 935589001140 motif 3; other site 935589001141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3171 935589001142 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 935589001143 DALR anticodon binding domain; Region: DALR_1; pfam05746 935589001144 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 935589001145 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 935589001146 Ligand binding site; other site 935589001147 metal-binding site 935589001148 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935589001149 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935589001150 active site 935589001151 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 935589001152 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 935589001153 RNA methyltransferase, RsmE family; Region: TIGR00046 935589001154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 935589001155 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 935589001156 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935589001157 active site 935589001158 hypothetical protein; Provisional; Region: PRK01752 935589001159 SEC-C motif; Region: SEC-C; pfam02810 935589001160 Transposase domain (DUF772); Region: DUF772; pfam05598 935589001161 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589001162 DDE superfamily endonuclease; Region: DDE_4; cl17710 935589001163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935589001164 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589001165 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935589001166 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 935589001167 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 935589001168 NAD(P) binding site [chemical binding]; other site 935589001169 homotetramer interface [polypeptide binding]; other site 935589001170 homodimer interface [polypeptide binding]; other site 935589001171 active site 935589001172 GMP synthase; Reviewed; Region: guaA; PRK00074 935589001173 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 935589001174 AMP/PPi binding site [chemical binding]; other site 935589001175 candidate oxyanion hole; other site 935589001176 catalytic triad [active] 935589001177 potential glutamine specificity residues [chemical binding]; other site 935589001178 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 935589001179 ATP Binding subdomain [chemical binding]; other site 935589001180 Ligand Binding sites [chemical binding]; other site 935589001181 Dimerization subdomain; other site 935589001182 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 935589001183 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935589001184 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 935589001185 Walker A/P-loop; other site 935589001186 ATP binding site [chemical binding]; other site 935589001187 Q-loop/lid; other site 935589001188 ABC transporter signature motif; other site 935589001189 Walker B; other site 935589001190 D-loop; other site 935589001191 H-loop/switch region; other site 935589001192 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 935589001193 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 935589001194 Predicted membrane protein [Function unknown]; Region: COG3326 935589001195 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 935589001196 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 935589001197 dimer interface [polypeptide binding]; other site 935589001198 active site 935589001199 CoA binding pocket [chemical binding]; other site 935589001200 putative phosphate acyltransferase; Provisional; Region: PRK05331 935589001201 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 935589001202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589001203 active site 935589001204 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 935589001205 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 935589001206 Maf-like protein; Region: Maf; pfam02545 935589001207 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935589001208 active site 935589001209 dimer interface [polypeptide binding]; other site 935589001210 Predicted methyltransferases [General function prediction only]; Region: COG0313 935589001211 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 935589001212 putative SAM binding site [chemical binding]; other site 935589001213 homodimer interface [polypeptide binding]; other site 935589001214 membrane protein insertase; Provisional; Region: PRK01318 935589001215 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 935589001216 hypothetical protein; Provisional; Region: PRK14373 935589001217 ribonuclease P; Reviewed; Region: rnpA; PRK04390 935589001218 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 935589001219 DnaA N-terminal domain; Region: DnaA_N; pfam11638 935589001220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589001221 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935589001222 Walker A motif; other site 935589001223 ATP binding site [chemical binding]; other site 935589001224 Walker B motif; other site 935589001225 arginine finger; other site 935589001226 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 935589001227 DnaA box-binding interface [nucleotide binding]; other site 935589001228 DNA polymerase III subunit beta; Validated; Region: PRK05643 935589001229 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 935589001230 putative DNA binding surface [nucleotide binding]; other site 935589001231 dimer interface [polypeptide binding]; other site 935589001232 beta-clamp/clamp loader binding surface; other site 935589001233 beta-clamp/translesion DNA polymerase binding surface; other site 935589001234 polyphosphate kinase; Provisional; Region: PRK05443 935589001235 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 935589001236 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 935589001237 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 935589001238 putative domain interface [polypeptide binding]; other site 935589001239 putative active site [active] 935589001240 catalytic site [active] 935589001241 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 935589001242 putative domain interface [polypeptide binding]; other site 935589001243 putative active site [active] 935589001244 catalytic site [active] 935589001245 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 935589001246 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 935589001247 Dam-replacing family; Region: DRP; pfam06044 935589001248 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 935589001249 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 935589001250 Predicted transcriptional regulator [Transcription]; Region: COG2944 935589001251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935589001252 non-specific DNA binding site [nucleotide binding]; other site 935589001253 salt bridge; other site 935589001254 sequence-specific DNA binding site [nucleotide binding]; other site 935589001255 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 935589001256 triosephosphate isomerase; Provisional; Region: PRK14567 935589001257 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 935589001258 substrate binding site [chemical binding]; other site 935589001259 dimer interface [polypeptide binding]; other site 935589001260 catalytic triad [active] 935589001261 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 935589001262 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 935589001263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589001264 S-adenosylmethionine binding site [chemical binding]; other site 935589001265 Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528 935589001266 active site residue [active] 935589001267 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935589001268 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935589001269 N-terminal plug; other site 935589001270 ligand-binding site [chemical binding]; other site 935589001271 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 935589001272 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 935589001273 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 935589001274 putative ligand binding residues [chemical binding]; other site 935589001275 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935589001276 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 935589001277 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935589001278 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 935589001279 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 935589001280 putative feedback inhibition sensing region; other site 935589001281 putative nucleotide binding site [chemical binding]; other site 935589001282 putative substrate binding site [chemical binding]; other site 935589001283 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935589001284 Coenzyme A binding pocket [chemical binding]; other site 935589001285 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 935589001286 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589001287 active site 935589001288 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 935589001289 active site 935589001290 Fe-S cluster binding site [ion binding]; other site 935589001291 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 935589001292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935589001293 Coenzyme A binding pocket [chemical binding]; other site 935589001294 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 935589001295 Glycoprotease family; Region: Peptidase_M22; pfam00814 935589001296 Lipoprotein GNA1870 C terminal like; Region: Lipoprot_C; pfam08794 935589001297 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 935589001298 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 935589001299 intersubunit interface [polypeptide binding]; other site 935589001300 active site 935589001301 zinc binding site [ion binding]; other site 935589001302 Na+ binding site [ion binding]; other site 935589001303 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 935589001304 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935589001305 active site 935589001306 Int/Topo IB signature motif; other site 935589001307 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 935589001308 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 935589001309 TPP-binding site; other site 935589001310 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 935589001311 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935589001312 PYR/PP interface [polypeptide binding]; other site 935589001313 dimer interface [polypeptide binding]; other site 935589001314 TPP binding site [chemical binding]; other site 935589001315 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935589001316 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 935589001317 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 935589001318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589001319 FeS/SAM binding site; other site 935589001320 TRAM domain; Region: TRAM; pfam01938 935589001321 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 935589001322 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935589001323 inhibitor-cofactor binding pocket; inhibition site 935589001324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589001325 catalytic residue [active] 935589001326 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 935589001327 catalytic site [active] 935589001328 putative active site [active] 935589001329 putative substrate binding site [chemical binding]; other site 935589001330 dimer interface [polypeptide binding]; other site 935589001331 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 935589001332 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589001333 S-adenosylmethionine binding site [chemical binding]; other site 935589001334 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 935589001335 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935589001336 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935589001337 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 935589001338 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 935589001339 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 935589001340 carboxyltransferase (CT) interaction site; other site 935589001341 biotinylation site [posttranslational modification]; other site 935589001342 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 935589001343 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 935589001344 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 935589001345 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935589001346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935589001347 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 935589001348 putative effector binding pocket; other site 935589001349 dimerization interface [polypeptide binding]; other site 935589001350 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 935589001351 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935589001352 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 935589001353 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 935589001354 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 935589001355 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935589001356 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 935589001357 IMP binding site; other site 935589001358 dimer interface [polypeptide binding]; other site 935589001359 interdomain contacts; other site 935589001360 partial ornithine binding site; other site 935589001361 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 935589001362 putative active site [active] 935589001363 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 935589001364 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935589001365 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 935589001366 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 935589001367 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 935589001368 catalytic site [active] 935589001369 subunit interface [polypeptide binding]; other site 935589001370 antiporter inner membrane protein; Provisional; Region: PRK11670 935589001371 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 935589001372 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 935589001373 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935589001374 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 935589001375 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 935589001376 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 935589001377 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 935589001378 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 935589001379 Substrate binding site; other site 935589001380 metal-binding site 935589001381 Predicted membrane protein [Function unknown]; Region: COG2510 935589001382 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 935589001383 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 935589001384 Potassium binding sites [ion binding]; other site 935589001385 Cesium cation binding sites [ion binding]; other site 935589001386 GTP-binding protein YchF; Reviewed; Region: PRK09601 935589001387 YchF GTPase; Region: YchF; cd01900 935589001388 G1 box; other site 935589001389 GTP/Mg2+ binding site [chemical binding]; other site 935589001390 Switch I region; other site 935589001391 G2 box; other site 935589001392 Switch II region; other site 935589001393 G3 box; other site 935589001394 G4 box; other site 935589001395 G5 box; other site 935589001396 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 935589001397 Transposase domain (DUF772); Region: DUF772; pfam05598 935589001398 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589001399 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935589001400 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 935589001401 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 935589001402 active site 935589001403 HIGH motif; other site 935589001404 dimer interface [polypeptide binding]; other site 935589001405 KMSKS motif; other site 935589001406 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 935589001407 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 935589001408 active site 935589001409 Riboflavin kinase; Region: Flavokinase; smart00904 935589001410 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 935589001411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935589001412 active site 935589001413 HIGH motif; other site 935589001414 nucleotide binding site [chemical binding]; other site 935589001415 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 935589001416 active site 935589001417 KMSKS motif; other site 935589001418 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 935589001419 tRNA binding surface [nucleotide binding]; other site 935589001420 anticodon binding site; other site 935589001421 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935589001422 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 935589001423 lipoprotein signal peptidase; Provisional; Region: PRK14787 935589001424 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 935589001425 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 935589001426 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935589001427 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589001428 motif II; other site 935589001429 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 935589001430 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 935589001431 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935589001432 N-terminal plug; other site 935589001433 ligand-binding site [chemical binding]; other site 935589001434 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 935589001435 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 935589001436 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 935589001437 putative active site [active] 935589001438 putative PHP Thumb interface [polypeptide binding]; other site 935589001439 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 935589001440 generic binding surface II; other site 935589001441 generic binding surface I; other site 935589001442 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589001443 RNA binding surface [nucleotide binding]; other site 935589001444 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 935589001445 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 935589001446 active site 935589001447 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 935589001448 Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977 935589001449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935589001450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589001451 homodimer interface [polypeptide binding]; other site 935589001452 catalytic residue [active] 935589001453 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 935589001454 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 935589001455 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 935589001456 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 935589001457 NAD(P) binding site [chemical binding]; other site 935589001458 homodimer interface [polypeptide binding]; other site 935589001459 substrate binding site [chemical binding]; other site 935589001460 active site 935589001461 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 935589001462 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 935589001463 inhibitor-cofactor binding pocket; inhibition site 935589001464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589001465 catalytic residue [active] 935589001466 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 935589001467 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 935589001468 Bacterial sugar transferase; Region: Bac_transf; pfam02397 935589001469 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 935589001470 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935589001471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935589001472 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 935589001473 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935589001474 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 935589001475 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 935589001476 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 935589001477 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 935589001478 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 935589001479 catalytic motif [active] 935589001480 Zn binding site [ion binding]; other site 935589001481 RibD C-terminal domain; Region: RibD_C; cl17279 935589001482 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 935589001483 ATP cone domain; Region: ATP-cone; pfam03477 935589001484 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 935589001485 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 935589001486 putative active site [active] 935589001487 putative dimer interface [polypeptide binding]; other site 935589001488 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 935589001489 active site 935589001490 dimer interface [polypeptide binding]; other site 935589001491 metal binding site [ion binding]; metal-binding site 935589001492 shikimate kinase; Reviewed; Region: aroK; PRK00131 935589001493 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 935589001494 ADP binding site [chemical binding]; other site 935589001495 magnesium binding site [ion binding]; other site 935589001496 putative shikimate binding site; other site 935589001497 AMIN domain; Region: AMIN; pfam11741 935589001498 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 935589001499 Secretin and TonB N terminus short domain; Region: STN; pfam07660 935589001500 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 935589001501 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 935589001502 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 935589001503 Pilus assembly protein, PilP; Region: PilP; pfam04351 935589001504 Tfp pilus assembly protein PilO [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilO; COG3167 935589001505 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 935589001506 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 935589001507 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 935589001508 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 935589001509 Transglycosylase; Region: Transgly; pfam00912 935589001510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935589001511 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 935589001512 G1 box; other site 935589001513 GTP/Mg2+ binding site [chemical binding]; other site 935589001514 Switch I region; other site 935589001515 G2 box; other site 935589001516 G3 box; other site 935589001517 Switch II region; other site 935589001518 G4 box; other site 935589001519 G5 box; other site 935589001520 Cytochrome c553 [Energy production and conversion]; Region: COG2863 935589001521 Cytochrome c; Region: Cytochrom_C; cl11414 935589001522 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 935589001523 ResB-like family; Region: ResB; pfam05140 935589001524 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 935589001525 UGMP family protein; Validated; Region: PRK09604 935589001526 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 935589001527 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935589001528 putative acyl-acceptor binding pocket; other site 935589001529 S-adenosylmethionine synthetase; Validated; Region: PRK05250 935589001530 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 935589001531 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 935589001532 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 935589001533 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 935589001534 Predicted flavoprotein [General function prediction only]; Region: COG0431 935589001535 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 935589001536 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 935589001537 Citrate transporter; Region: CitMHS; pfam03600 935589001538 cheY-homologous receiver domain; Region: REC; smart00448 935589001539 sensor protein QseC; Provisional; Region: PRK10337 935589001540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935589001541 dimer interface [polypeptide binding]; other site 935589001542 phosphorylation site [posttranslational modification] 935589001543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589001544 ATP binding site [chemical binding]; other site 935589001545 Mg2+ binding site [ion binding]; other site 935589001546 G-X-G motif; other site 935589001547 ribonuclease G; Provisional; Region: PRK11712 935589001548 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 935589001549 homodimer interface [polypeptide binding]; other site 935589001550 oligonucleotide binding site [chemical binding]; other site 935589001551 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 935589001552 GSH binding site [chemical binding]; other site 935589001553 catalytic residues [active] 935589001554 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 935589001555 SecA binding site; other site 935589001556 Preprotein binding site; other site 935589001557 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 935589001558 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 935589001559 generic binding surface II; other site 935589001560 ssDNA binding site; other site 935589001561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589001562 ATP binding site [chemical binding]; other site 935589001563 putative Mg++ binding site [ion binding]; other site 935589001564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935589001565 nucleotide binding region [chemical binding]; other site 935589001566 ATP-binding site [chemical binding]; other site 935589001567 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 935589001568 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935589001569 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 935589001570 Uncharacterized conserved protein [Function unknown]; Region: COG2850 935589001571 Cupin-like domain; Region: Cupin_8; pfam13621 935589001572 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935589001573 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935589001574 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935589001575 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935589001576 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589001577 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589001578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3792 935589001579 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589001580 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589001581 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589001582 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935589001583 Integrase core domain; Region: rve; pfam00665 935589001584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589001585 ribonuclease BN/unknown domain fusion protein; Reviewed; Region: rbn; PRK04214 935589001586 YihY family inner membrane protein; Region: yihY_not_rbn; TIGR00765 935589001587 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 935589001588 Ligand Binding Site [chemical binding]; other site 935589001589 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 935589001590 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 935589001591 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 935589001592 active site 935589001593 Predicted membrane protein [Function unknown]; Region: COG3759 935589001594 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 935589001595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589001596 FeS/SAM binding site; other site 935589001597 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 935589001598 beta-hexosaminidase; Provisional; Region: PRK05337 935589001599 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 935589001600 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 935589001601 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 935589001602 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935589001603 protein binding site [polypeptide binding]; other site 935589001604 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 935589001605 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 935589001606 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935589001607 minor groove reading motif; other site 935589001608 helix-hairpin-helix signature motif; other site 935589001609 substrate binding pocket [chemical binding]; other site 935589001610 active site 935589001611 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 935589001612 Predicted membrane protein [Function unknown]; Region: COG1238 935589001613 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 935589001614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589001615 putative substrate translocation pore; other site 935589001616 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 935589001617 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 935589001618 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935589001619 Transporter associated domain; Region: CorC_HlyC; smart01091 935589001620 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 935589001621 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 935589001622 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 935589001623 domain interfaces; other site 935589001624 active site 935589001625 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 935589001626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935589001627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589001628 homodimer interface [polypeptide binding]; other site 935589001629 catalytic residue [active] 935589001630 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 935589001631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4391 935589001632 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 935589001633 L-lactate permease; Region: Lactate_perm; cl00701 935589001634 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 935589001635 putative active site [active] 935589001636 putative metal binding site [ion binding]; other site 935589001637 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 935589001638 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935589001639 Walker A/P-loop; other site 935589001640 ATP binding site [chemical binding]; other site 935589001641 Q-loop/lid; other site 935589001642 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 935589001643 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 935589001644 ABC transporter signature motif; other site 935589001645 Walker B; other site 935589001646 D-loop; other site 935589001647 H-loop/switch region; other site 935589001648 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 935589001649 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 935589001650 NAD binding site [chemical binding]; other site 935589001651 substrate binding site [chemical binding]; other site 935589001652 catalytic Zn binding site [ion binding]; other site 935589001653 tetramer interface [polypeptide binding]; other site 935589001654 structural Zn binding site [ion binding]; other site 935589001655 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 935589001656 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 935589001657 macrolide transporter subunit MacA; Provisional; Region: PRK11578 935589001658 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935589001659 HlyD family secretion protein; Region: HlyD_3; pfam13437 935589001660 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 935589001661 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935589001662 Walker A/P-loop; other site 935589001663 ATP binding site [chemical binding]; other site 935589001664 Q-loop/lid; other site 935589001665 ABC transporter signature motif; other site 935589001666 Walker B; other site 935589001667 D-loop; other site 935589001668 H-loop/switch region; other site 935589001669 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935589001670 FtsX-like permease family; Region: FtsX; pfam02687 935589001671 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 935589001672 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 935589001673 dimerization domain [polypeptide binding]; other site 935589001674 dimer interface [polypeptide binding]; other site 935589001675 catalytic residues [active] 935589001676 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 935589001677 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589001678 ATP binding site [chemical binding]; other site 935589001679 putative Mg++ binding site [ion binding]; other site 935589001680 helicase superfamily c-terminal domain; Region: HELICc; smart00490 935589001681 ATP-binding site [chemical binding]; other site 935589001682 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935589001683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935589001684 B-Box C-terminal domain; Region: BBC; smart00502 935589001685 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935589001686 Transposase domain (DUF772); Region: DUF772; pfam05598 935589001687 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589001688 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935589001689 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 935589001690 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 935589001691 nucleotide binding site [chemical binding]; other site 935589001692 NEF interaction site [polypeptide binding]; other site 935589001693 SBD interface [polypeptide binding]; other site 935589001694 Predicted transcriptional regulator [Transcription]; Region: COG2932 935589001695 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935589001696 Catalytic site [active] 935589001697 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 935589001698 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 935589001699 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 935589001700 serine acetyltransferase; Provisional; Region: cysE; PRK11132 935589001701 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 935589001702 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 935589001703 trimer interface [polypeptide binding]; other site 935589001704 active site 935589001705 substrate binding site [chemical binding]; other site 935589001706 CoA binding site [chemical binding]; other site 935589001707 GrpE; Region: GrpE; pfam01025 935589001708 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 935589001709 dimer interface [polypeptide binding]; other site 935589001710 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 935589001711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 935589001712 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 935589001713 ApbE family; Region: ApbE; pfam02424 935589001714 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 935589001715 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935589001716 catalytic loop [active] 935589001717 iron binding site [ion binding]; other site 935589001718 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 935589001719 FAD binding pocket [chemical binding]; other site 935589001720 FAD binding motif [chemical binding]; other site 935589001721 phosphate binding motif [ion binding]; other site 935589001722 beta-alpha-beta structure motif; other site 935589001723 NAD binding pocket [chemical binding]; other site 935589001724 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 935589001725 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 935589001726 Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869 935589001727 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 935589001728 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 935589001729 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 935589001730 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935589001731 E3 interaction surface; other site 935589001732 lipoyl attachment site [posttranslational modification]; other site 935589001733 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 935589001734 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 935589001735 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 935589001736 transmembrane helices; other site 935589001737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 935589001738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3310 935589001739 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 935589001740 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935589001741 putative DNA binding site [nucleotide binding]; other site 935589001742 putative Zn2+ binding site [ion binding]; other site 935589001743 AsnC family; Region: AsnC_trans_reg; pfam01037 935589001744 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 935589001745 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 935589001746 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 935589001747 lipoyl attachment site [posttranslational modification]; other site 935589001748 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 935589001749 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 935589001750 tRNA; other site 935589001751 putative tRNA binding site [nucleotide binding]; other site 935589001752 putative NADP binding site [chemical binding]; other site 935589001753 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 935589001754 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 935589001755 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 935589001756 Predicted lipoprotein involved in nitrous oxide reduction [Energy production and conversion]; Region: NosL; COG4314 935589001757 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 935589001758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935589001759 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 935589001760 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 935589001761 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 935589001762 putative active site [active] 935589001763 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589001764 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589001765 Homeodomain-like domain; Region: HTH_32; pfam13565 935589001766 Integrase core domain; Region: rve; pfam00665 935589001767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589001768 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 935589001769 putative active site [active] 935589001770 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589001771 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 935589001772 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 935589001773 metal binding site [ion binding]; metal-binding site 935589001774 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 935589001775 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 935589001776 ABC-ATPase subunit interface; other site 935589001777 dimer interface [polypeptide binding]; other site 935589001778 putative PBP binding regions; other site 935589001779 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 935589001780 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 935589001781 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 935589001782 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 935589001783 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 935589001784 RimM N-terminal domain; Region: RimM; pfam01782 935589001785 PRC-barrel domain; Region: PRC; pfam05239 935589001786 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 935589001787 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 935589001788 CoA binding domain; Region: CoA_binding_2; pfam13380 935589001789 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935589001790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935589001791 Coenzyme A binding pocket [chemical binding]; other site 935589001792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 935589001793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935589001794 dimerization interface [polypeptide binding]; other site 935589001795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 935589001796 dimer interface [polypeptide binding]; other site 935589001797 phosphorylation site [posttranslational modification] 935589001798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589001799 ATP binding site [chemical binding]; other site 935589001800 Mg2+ binding site [ion binding]; other site 935589001801 G-X-G motif; other site 935589001802 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 935589001803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935589001804 active site 935589001805 phosphorylation site [posttranslational modification] 935589001806 intermolecular recognition site; other site 935589001807 dimerization interface [polypeptide binding]; other site 935589001808 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 935589001809 DNA binding site [nucleotide binding] 935589001810 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 935589001811 O-Antigen ligase; Region: Wzy_C; pfam04932 935589001812 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 935589001813 Predicted membrane protein [Function unknown]; Region: COG3308 935589001814 Maf-like protein; Region: Maf; pfam02545 935589001815 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 935589001816 active site 935589001817 dimer interface [polypeptide binding]; other site 935589001818 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 935589001819 sec-independent translocase; Provisional; Region: PRK00708 935589001820 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 935589001821 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 935589001822 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 935589001823 nucleotide binding site/active site [active] 935589001824 HIT family signature motif; other site 935589001825 catalytic residue [active] 935589001826 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 935589001827 metal binding site [ion binding]; metal-binding site 935589001828 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 935589001829 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 935589001830 putative NAD(P) binding site [chemical binding]; other site 935589001831 catalytic Zn binding site [ion binding]; other site 935589001832 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 935589001833 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 935589001834 putative active site [active] 935589001835 Zn binding site [ion binding]; other site 935589001836 Preprotein translocase subunit; Region: YajC; pfam02699 935589001837 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 935589001838 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 935589001839 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 935589001840 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 935589001841 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 935589001842 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 935589001843 Protein export membrane protein; Region: SecD_SecF; pfam02355 935589001844 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 935589001845 16S/18S rRNA binding site [nucleotide binding]; other site 935589001846 S13e-L30e interaction site [polypeptide binding]; other site 935589001847 25S rRNA binding site [nucleotide binding]; other site 935589001848 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 935589001849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589001850 Walker A/P-loop; other site 935589001851 ATP binding site [chemical binding]; other site 935589001852 Q-loop/lid; other site 935589001853 ABC transporter signature motif; other site 935589001854 Walker B; other site 935589001855 D-loop; other site 935589001856 H-loop/switch region; other site 935589001857 TOBE domain; Region: TOBE_2; pfam08402 935589001858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589001859 dimer interface [polypeptide binding]; other site 935589001860 conserved gate region; other site 935589001861 putative PBP binding loops; other site 935589001862 ABC-ATPase subunit interface; other site 935589001863 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 935589001864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589001865 dimer interface [polypeptide binding]; other site 935589001866 conserved gate region; other site 935589001867 putative PBP binding loops; other site 935589001868 ABC-ATPase subunit interface; other site 935589001869 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 935589001870 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 935589001871 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 935589001872 transcription termination factor Rho; Provisional; Region: rho; PRK09376 935589001873 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 935589001874 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 935589001875 RNA binding site [nucleotide binding]; other site 935589001876 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 935589001877 multimer interface [polypeptide binding]; other site 935589001878 Walker A motif; other site 935589001879 ATP binding site [chemical binding]; other site 935589001880 Walker B motif; other site 935589001881 phosphoenolpyruvate synthase; Validated; Region: PRK06464 935589001882 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 935589001883 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935589001884 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935589001885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 935589001886 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 935589001887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589001888 motif II; other site 935589001889 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 935589001890 dinuclear metal binding motif [ion binding]; other site 935589001891 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 935589001892 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 935589001893 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 935589001894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935589001895 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 935589001896 active site 935589001897 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 935589001898 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 935589001899 trimer interface [polypeptide binding]; other site 935589001900 putative metal binding site [ion binding]; other site 935589001901 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 935589001902 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 935589001903 G1 box; other site 935589001904 putative GEF interaction site [polypeptide binding]; other site 935589001905 GTP/Mg2+ binding site [chemical binding]; other site 935589001906 Switch I region; other site 935589001907 G2 box; other site 935589001908 G3 box; other site 935589001909 Switch II region; other site 935589001910 G4 box; other site 935589001911 G5 box; other site 935589001912 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 935589001913 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 935589001914 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 935589001915 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935589001916 substrate binding site [chemical binding]; other site 935589001917 glutamase interaction surface [polypeptide binding]; other site 935589001918 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 935589001919 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 935589001920 catalytic residues [active] 935589001921 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 935589001922 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 935589001923 putative active site [active] 935589001924 oxyanion strand; other site 935589001925 catalytic triad [active] 935589001926 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 935589001927 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935589001928 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935589001929 Walker A/P-loop; other site 935589001930 ATP binding site [chemical binding]; other site 935589001931 Q-loop/lid; other site 935589001932 ABC transporter signature motif; other site 935589001933 Walker B; other site 935589001934 D-loop; other site 935589001935 H-loop/switch region; other site 935589001936 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 935589001937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589001938 dimer interface [polypeptide binding]; other site 935589001939 conserved gate region; other site 935589001940 putative PBP binding loops; other site 935589001941 ABC-ATPase subunit interface; other site 935589001942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589001943 dimer interface [polypeptide binding]; other site 935589001944 conserved gate region; other site 935589001945 ABC-ATPase subunit interface; other site 935589001946 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 935589001947 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 935589001948 argininosuccinate lyase; Provisional; Region: PRK00855 935589001949 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 935589001950 active sites [active] 935589001951 tetramer interface [polypeptide binding]; other site 935589001952 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 935589001953 active site 935589001954 tetramer interface; other site 935589001955 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 935589001956 active site 935589001957 dimerization interface [polypeptide binding]; other site 935589001958 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 935589001959 dimer interface [polypeptide binding]; other site 935589001960 substrate binding site [chemical binding]; other site 935589001961 metal binding sites [ion binding]; metal-binding site 935589001962 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 935589001963 nudix motif; other site 935589001964 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935589001965 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 935589001966 RNAase interaction site [polypeptide binding]; other site 935589001967 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935589001968 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 935589001969 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 935589001970 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 935589001971 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935589001972 Cation transport protein; Region: TrkH; cl17365 935589001973 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 935589001974 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 935589001975 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 935589001976 active site 935589001977 metal binding site [ion binding]; metal-binding site 935589001978 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 935589001979 homotrimer interaction site [polypeptide binding]; other site 935589001980 putative active site [active] 935589001981 Opacity family porin protein; Region: Opacity; pfam02462 935589001982 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 935589001983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589001984 FeS/SAM binding site; other site 935589001985 HemN C-terminal domain; Region: HemN_C; pfam06969 935589001986 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 935589001987 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 935589001988 nucleotide binding pocket [chemical binding]; other site 935589001989 K-X-D-G motif; other site 935589001990 catalytic site [active] 935589001991 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 935589001992 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 935589001993 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 935589001994 Dimer interface [polypeptide binding]; other site 935589001995 BRCT sequence motif; other site 935589001996 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 935589001997 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 935589001998 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 935589001999 amidase catalytic site [active] 935589002000 Zn binding residues [ion binding]; other site 935589002001 substrate binding site [chemical binding]; other site 935589002002 YceG-like family; Region: YceG; pfam02618 935589002003 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 935589002004 dimerization interface [polypeptide binding]; other site 935589002005 thymidylate kinase; Validated; Region: tmk; PRK00698 935589002006 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 935589002007 TMP-binding site; other site 935589002008 ATP-binding site [chemical binding]; other site 935589002009 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 935589002010 Malic enzyme, N-terminal domain; Region: malic; pfam00390 935589002011 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 935589002012 putative NAD(P) binding site [chemical binding]; other site 935589002013 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 935589002014 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 935589002015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3184 935589002016 Uncharacterized conserved protein [Function unknown]; Region: COG2835 935589002017 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 935589002018 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 935589002019 Ligand binding site; other site 935589002020 oligomer interface; other site 935589002021 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 935589002022 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 935589002023 substrate binding site [chemical binding]; other site 935589002024 active site 935589002025 catalytic residues [active] 935589002026 heterodimer interface [polypeptide binding]; other site 935589002027 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 935589002028 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 935589002029 CNP1-like family; Region: CNP1; pfam08750 935589002030 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 935589002031 CPxP motif; other site 935589002032 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 935589002033 active site 935589002034 substrate binding pocket [chemical binding]; other site 935589002035 dimer interface [polypeptide binding]; other site 935589002036 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 935589002037 putative RNA binding site [nucleotide binding]; other site 935589002038 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 935589002039 homopentamer interface [polypeptide binding]; other site 935589002040 active site 935589002041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4859 935589002042 ribonuclease III; Reviewed; Region: rnc; PRK00102 935589002043 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 935589002044 dimerization interface [polypeptide binding]; other site 935589002045 active site 935589002046 metal binding site [ion binding]; metal-binding site 935589002047 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 935589002048 dsRNA binding site [nucleotide binding]; other site 935589002049 GTPase Era; Reviewed; Region: era; PRK00089 935589002050 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 935589002051 G1 box; other site 935589002052 GTP/Mg2+ binding site [chemical binding]; other site 935589002053 Switch I region; other site 935589002054 G2 box; other site 935589002055 Switch II region; other site 935589002056 G3 box; other site 935589002057 G4 box; other site 935589002058 G5 box; other site 935589002059 KH domain; Region: KH_2; pfam07650 935589002060 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 935589002061 active site 935589002062 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 935589002063 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935589002064 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935589002065 amidophosphoribosyltransferase; Provisional; Region: PRK09246 935589002066 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 935589002067 active site 935589002068 tetramer interface [polypeptide binding]; other site 935589002069 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589002070 active site 935589002071 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 935589002072 Colicin V production protein; Region: Colicin_V; pfam02674 935589002073 cell division protein FtsN; Region: ftsN; TIGR02223 935589002074 Sporulation related domain; Region: SPOR; pfam05036 935589002075 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 935589002076 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935589002077 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935589002078 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935589002079 Walker A/P-loop; other site 935589002080 ATP binding site [chemical binding]; other site 935589002081 Q-loop/lid; other site 935589002082 ABC transporter signature motif; other site 935589002083 Walker B; other site 935589002084 D-loop; other site 935589002085 H-loop/switch region; other site 935589002086 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 935589002087 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 935589002088 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 935589002089 putative active site [active] 935589002090 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 935589002091 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 935589002092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589002093 catalytic residue [active] 935589002094 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 935589002095 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 935589002096 Competence protein; Region: Competence; pfam03772 935589002097 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 935589002098 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 935589002099 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 935589002100 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935589002101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589002102 RNA binding surface [nucleotide binding]; other site 935589002103 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935589002104 active site 935589002105 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 935589002106 Sodium Bile acid symporter family; Region: SBF; pfam01758 935589002107 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 935589002108 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 935589002109 Rare lipoprotein B [Cell envelope biogenesis, outer membrane]; Region: RlpB; COG2980 935589002110 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 935589002111 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 935589002112 Predicted membrane protein/domain [Function unknown]; Region: COG1714 935589002113 hypothetical protein; Provisional; Region: PRK11820 935589002114 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 935589002115 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 935589002116 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 935589002117 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935589002118 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935589002119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935589002120 DNA binding residues [nucleotide binding] 935589002121 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 935589002122 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 935589002123 putative active site [active] 935589002124 catalytic triad [active] 935589002125 putative dimer interface [polypeptide binding]; other site 935589002126 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589002127 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589002128 Homeodomain-like domain; Region: HTH_32; pfam13565 935589002129 Integrase core domain; Region: rve; pfam00665 935589002130 potassium/proton antiporter; Reviewed; Region: PRK05326 935589002131 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 935589002132 Cytochrome c; Region: Cytochrom_C; pfam00034 935589002133 ferrochelatase; Reviewed; Region: hemH; PRK00035 935589002134 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 935589002135 C-terminal domain interface [polypeptide binding]; other site 935589002136 active site 935589002137 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 935589002138 active site 935589002139 N-terminal domain interface [polypeptide binding]; other site 935589002140 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 935589002141 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 935589002142 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 935589002143 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 935589002144 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 935589002145 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 935589002146 active site 935589002147 dimer interface [polypeptide binding]; other site 935589002148 motif 1; other site 935589002149 motif 2; other site 935589002150 motif 3; other site 935589002151 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 935589002152 anticodon binding site; other site 935589002153 translation initiation factor IF-3; Region: infC; TIGR00168 935589002154 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 935589002155 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 935589002156 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 935589002157 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 935589002158 23S rRNA binding site [nucleotide binding]; other site 935589002159 L21 binding site [polypeptide binding]; other site 935589002160 L13 binding site [polypeptide binding]; other site 935589002161 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 935589002162 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 935589002163 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 935589002164 dimer interface [polypeptide binding]; other site 935589002165 motif 1; other site 935589002166 active site 935589002167 motif 2; other site 935589002168 motif 3; other site 935589002169 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 935589002170 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589002171 cofactor binding site; other site 935589002172 DNA binding site [nucleotide binding] 935589002173 substrate interaction site [chemical binding]; other site 935589002174 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 935589002175 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 935589002176 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 935589002177 DNA methylase; Region: N6_N4_Mtase; cl17433 935589002178 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 935589002179 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 935589002180 putative tRNA-binding site [nucleotide binding]; other site 935589002181 B3/4 domain; Region: B3_4; pfam03483 935589002182 tRNA synthetase B5 domain; Region: B5; smart00874 935589002183 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 935589002184 dimer interface [polypeptide binding]; other site 935589002185 motif 1; other site 935589002186 motif 3; other site 935589002187 motif 2; other site 935589002188 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 935589002189 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935589002190 IHF - DNA interface [nucleotide binding]; other site 935589002191 IHF dimer interface [polypeptide binding]; other site 935589002192 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 935589002193 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 935589002194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935589002195 inhibitor-cofactor binding pocket; inhibition site 935589002196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589002197 catalytic residue [active] 935589002198 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 935589002199 AAA domain; Region: AAA_26; pfam13500 935589002200 4-hydroxybenzoate synthetase (chorismate lyase) [Coenzyme metabolism]; Region: UbiC; COG3161 935589002201 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 935589002202 UbiA prenyltransferase family; Region: UbiA; pfam01040 935589002203 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 935589002204 active site 935589002205 phosphorylation site [posttranslational modification] 935589002206 HPr kinase/phosphorylase; Provisional; Region: PRK05428 935589002207 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 935589002208 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 935589002209 Hpr binding site; other site 935589002210 active site 935589002211 homohexamer subunit interaction site [polypeptide binding]; other site 935589002212 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 935589002213 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 935589002214 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 935589002215 GTP/Mg2+ binding site [chemical binding]; other site 935589002216 G4 box; other site 935589002217 G5 box; other site 935589002218 G1 box; other site 935589002219 Switch I region; other site 935589002220 G2 box; other site 935589002221 G3 box; other site 935589002222 Switch II region; other site 935589002223 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 935589002224 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 935589002225 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935589002226 Walker A/P-loop; other site 935589002227 ATP binding site [chemical binding]; other site 935589002228 Q-loop/lid; other site 935589002229 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 935589002230 ABC transporter signature motif; other site 935589002231 Walker B; other site 935589002232 D-loop; other site 935589002233 H-loop/switch region; other site 935589002234 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935589002235 tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC, C-terminal domain; Region: MnmC_Cterm; TIGR03197 935589002236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 935589002237 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 935589002238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589002239 S-adenosylmethionine binding site [chemical binding]; other site 935589002240 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 935589002241 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 935589002242 catalytic center binding site [active] 935589002243 ATP binding site [chemical binding]; other site 935589002244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3094 935589002245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589002246 S-adenosylmethionine binding site [chemical binding]; other site 935589002247 bacterial Hfq-like; Region: Hfq; cd01716 935589002248 hexamer interface [polypeptide binding]; other site 935589002249 Sm1 motif; other site 935589002250 RNA binding site [nucleotide binding]; other site 935589002251 Sm2 motif; other site 935589002252 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935589002253 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 935589002254 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 935589002255 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935589002256 catalytic triad [active] 935589002257 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 935589002258 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 935589002259 active site 935589002260 Int/Topo IB signature motif; other site 935589002261 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 935589002262 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 935589002263 dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214 935589002264 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 935589002265 NADP binding site [chemical binding]; other site 935589002266 active site 935589002267 putative substrate binding site [chemical binding]; other site 935589002268 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 935589002269 ATP binding site [chemical binding]; other site 935589002270 active site 935589002271 substrate binding site [chemical binding]; other site 935589002272 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 935589002273 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 935589002274 RNase E interface [polypeptide binding]; other site 935589002275 trimer interface [polypeptide binding]; other site 935589002276 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 935589002277 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 935589002278 RNase E interface [polypeptide binding]; other site 935589002279 trimer interface [polypeptide binding]; other site 935589002280 active site 935589002281 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 935589002282 putative nucleic acid binding region [nucleotide binding]; other site 935589002283 G-X-X-G motif; other site 935589002284 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 935589002285 RNA binding site [nucleotide binding]; other site 935589002286 domain interface; other site 935589002287 Uncharacterized conserved protein [Function unknown]; Region: COG2836 935589002288 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 935589002289 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935589002290 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 935589002291 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 935589002292 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 935589002293 dimer interface [polypeptide binding]; other site 935589002294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589002295 catalytic residue [active] 935589002296 EamA-like transporter family; Region: EamA; pfam00892 935589002297 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 935589002298 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 935589002299 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935589002300 Catalytic site [active] 935589002301 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 935589002302 GTP-binding protein LepA; Provisional; Region: PRK05433 935589002303 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 935589002304 G1 box; other site 935589002305 putative GEF interaction site [polypeptide binding]; other site 935589002306 GTP/Mg2+ binding site [chemical binding]; other site 935589002307 Switch I region; other site 935589002308 G2 box; other site 935589002309 G3 box; other site 935589002310 Switch II region; other site 935589002311 G4 box; other site 935589002312 G5 box; other site 935589002313 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 935589002314 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 935589002315 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 935589002316 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 935589002317 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 935589002318 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 935589002319 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 935589002320 Walker A motif; other site 935589002321 ATP binding site [chemical binding]; other site 935589002322 Walker B motif; other site 935589002323 DNA polymerase III subunit delta'; Validated; Region: PRK08699 935589002324 DNA polymerase III subunit delta'; Validated; Region: PRK08485 935589002325 Tfp pilus assembly protein PilZ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilZ; COG3215 935589002326 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935589002327 active site 935589002328 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 935589002329 Domain of unknown function (DUF333); Region: DUF333; pfam03891 935589002330 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 935589002331 putative GSH binding site [chemical binding]; other site 935589002332 catalytic residues [active] 935589002333 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589002334 active site 935589002335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4390 935589002336 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 935589002337 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 935589002338 active site 935589002339 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 935589002340 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 935589002341 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071 935589002342 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 935589002343 substrate binding site [chemical binding]; other site 935589002344 active site 935589002345 DNA repair protein RadA; Provisional; Region: PRK11823 935589002346 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 935589002347 Walker A motif/ATP binding site; other site 935589002348 ATP binding site [chemical binding]; other site 935589002349 Walker B motif; other site 935589002350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935589002351 Uncharacterized conserved protein [Function unknown]; Region: COG3439 935589002352 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 935589002353 active site residue [active] 935589002354 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 935589002355 Part of AAA domain; Region: AAA_19; pfam13245 935589002356 Family description; Region: UvrD_C_2; pfam13538 935589002357 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 935589002358 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 935589002359 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935589002360 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935589002361 substrate binding pocket [chemical binding]; other site 935589002362 membrane-bound complex binding site; other site 935589002363 hinge residues; other site 935589002364 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 935589002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589002366 dimer interface [polypeptide binding]; other site 935589002367 conserved gate region; other site 935589002368 putative PBP binding loops; other site 935589002369 ABC-ATPase subunit interface; other site 935589002370 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 935589002371 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 935589002372 Walker A/P-loop; other site 935589002373 ATP binding site [chemical binding]; other site 935589002374 Q-loop/lid; other site 935589002375 ABC transporter signature motif; other site 935589002376 Walker B; other site 935589002377 D-loop; other site 935589002378 H-loop/switch region; other site 935589002379 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 935589002380 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 935589002381 active site 935589002382 substrate binding site [chemical binding]; other site 935589002383 metal binding site [ion binding]; metal-binding site 935589002384 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 935589002385 active site 935589002386 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935589002387 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 935589002388 VanZ like family; Region: VanZ; cl01971 935589002389 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 935589002390 putative active site [active] 935589002391 catalytic residue [active] 935589002392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 935589002393 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 935589002394 putative coenzyme Q binding site [chemical binding]; other site 935589002395 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 935589002396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589002397 Walker A motif; other site 935589002398 ATP binding site [chemical binding]; other site 935589002399 Walker B motif; other site 935589002400 arginine finger; other site 935589002401 Peptidase family M41; Region: Peptidase_M41; pfam01434 935589002402 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 935589002403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589002404 S-adenosylmethionine binding site [chemical binding]; other site 935589002405 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 935589002406 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 935589002407 dimer interface [polypeptide binding]; other site 935589002408 active site 935589002409 aspartate-rich active site metal binding site; other site 935589002410 allosteric magnesium binding site [ion binding]; other site 935589002411 Schiff base residues; other site 935589002412 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 935589002413 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935589002414 homodimer interface [polypeptide binding]; other site 935589002415 substrate-cofactor binding pocket; other site 935589002416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589002417 catalytic residue [active] 935589002418 putative GTP cyclohydrolase; Provisional; Region: PRK13674 935589002419 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 935589002420 dimer interface [polypeptide binding]; other site 935589002421 FMN binding site [chemical binding]; other site 935589002422 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935589002423 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589002424 RNA binding surface [nucleotide binding]; other site 935589002425 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 935589002426 active site 935589002427 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04539 935589002428 ATP-NAD kinase; Region: NAD_kinase; pfam01513 935589002429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 935589002430 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 935589002431 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 935589002432 putative NAD(P) binding site [chemical binding]; other site 935589002433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 935589002434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935589002435 Bacterial transcriptional repressor; Region: TetR; pfam13972 935589002436 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 935589002437 FAD binding domain; Region: FAD_binding_4; pfam01565 935589002438 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 935589002439 multidrug efflux protein; Reviewed; Region: PRK01766 935589002440 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 935589002441 cation binding site [ion binding]; other site 935589002442 ATP phosphoribosyltransferase involved in histidine biosynthesis [Amino acid transport and metabolism]; Region: HisZ; COG3705 935589002443 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935589002444 motif 1; other site 935589002445 dimer interface [polypeptide binding]; other site 935589002446 active site 935589002447 motif 2; other site 935589002448 motif 3; other site 935589002449 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 935589002450 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 935589002451 GDP-binding site [chemical binding]; other site 935589002452 ACT binding site; other site 935589002453 IMP binding site; other site 935589002454 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935589002455 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935589002456 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935589002457 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 935589002458 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935589002459 NUMOD1 domain; Region: NUMOD1; pfam07453 935589002460 heat shock protein HtpX; Provisional; Region: PRK05457 935589002461 adenylate kinase; Reviewed; Region: adk; PRK00279 935589002462 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 935589002463 AMP-binding site [chemical binding]; other site 935589002464 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 935589002465 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 935589002466 active site 935589002467 dimer interface [polypeptide binding]; other site 935589002468 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 935589002469 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 935589002470 putative ribose interaction site [chemical binding]; other site 935589002471 putative ADP binding site [chemical binding]; other site 935589002472 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935589002473 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589002474 cofactor binding site; other site 935589002475 DNA binding site [nucleotide binding] 935589002476 substrate interaction site [chemical binding]; other site 935589002477 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589002478 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 935589002479 HNH endonuclease; Region: HNH_2; pfam13391 935589002480 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 935589002481 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 935589002482 NADP binding site [chemical binding]; other site 935589002483 homopentamer interface [polypeptide binding]; other site 935589002484 substrate binding site [chemical binding]; other site 935589002485 active site 935589002486 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 935589002487 HsdM N-terminal domain; Region: HsdM_N; pfam12161 935589002488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589002489 S-adenosylmethionine binding site [chemical binding]; other site 935589002490 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 935589002491 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 935589002492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589002493 ATP binding site [chemical binding]; other site 935589002494 putative Mg++ binding site [ion binding]; other site 935589002495 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 935589002496 Clp amino terminal domain; Region: Clp_N; pfam02861 935589002497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589002498 Walker A motif; other site 935589002499 ATP binding site [chemical binding]; other site 935589002500 Walker B motif; other site 935589002501 arginine finger; other site 935589002502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589002503 Walker A motif; other site 935589002504 ATP binding site [chemical binding]; other site 935589002505 Walker B motif; other site 935589002506 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935589002507 Uncharacterized conserved protein [Function unknown]; Region: COG2127 935589002508 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 935589002509 DNA-binding site [nucleotide binding]; DNA binding site 935589002510 RNA-binding motif; other site 935589002511 peptidase PmbA; Provisional; Region: PRK11040 935589002512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3028 935589002513 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 935589002514 DHH family; Region: DHH; pfam01368 935589002515 DHHA1 domain; Region: DHHA1; pfam02272 935589002516 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589002517 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589002518 Homeodomain-like domain; Region: HTH_32; pfam13565 935589002519 Integrase core domain; Region: rve; pfam00665 935589002520 poly(A) polymerase; Region: pcnB; TIGR01942 935589002521 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935589002522 active site 935589002523 NTP binding site [chemical binding]; other site 935589002524 metal binding triad [ion binding]; metal-binding site 935589002525 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935589002526 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 935589002527 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 935589002528 PhoH-like protein; Region: PhoH; pfam02562 935589002529 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 935589002530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935589002531 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3471 935589002532 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935589002533 trimer interface [polypeptide binding]; other site 935589002534 active site 935589002535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 935589002536 MORN repeat; Region: MORN; cl14787 935589002537 Putative exonuclease, RdgC; Region: RdgC; cl01122 935589002538 GTP-binding protein Der; Reviewed; Region: PRK00093 935589002539 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 935589002540 G1 box; other site 935589002541 GTP/Mg2+ binding site [chemical binding]; other site 935589002542 Switch I region; other site 935589002543 G2 box; other site 935589002544 Switch II region; other site 935589002545 G3 box; other site 935589002546 G4 box; other site 935589002547 G5 box; other site 935589002548 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 935589002549 G1 box; other site 935589002550 GTP/Mg2+ binding site [chemical binding]; other site 935589002551 Switch I region; other site 935589002552 G2 box; other site 935589002553 G3 box; other site 935589002554 Switch II region; other site 935589002555 G4 box; other site 935589002556 G5 box; other site 935589002557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 935589002558 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 935589002559 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 935589002560 dimer interface [polypeptide binding]; other site 935589002561 motif 1; other site 935589002562 active site 935589002563 motif 2; other site 935589002564 motif 3; other site 935589002565 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 935589002566 anticodon binding site; other site 935589002567 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 935589002568 putative active site [active] 935589002569 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 935589002570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935589002571 Pseudouridine synthase, a subgroup of the RluA family; Region: PSRA_1; cd02558 935589002572 probable active site [active] 935589002573 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 935589002574 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 935589002575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589002576 S-adenosylmethionine binding site [chemical binding]; other site 935589002577 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 935589002578 oligomerization interface [polypeptide binding]; other site 935589002579 active site 935589002580 metal binding site [ion binding]; metal-binding site 935589002581 pantoate--beta-alanine ligase; Region: panC; TIGR00018 935589002582 Pantoate-beta-alanine ligase; Region: PanC; cd00560 935589002583 active site 935589002584 ATP-binding site [chemical binding]; other site 935589002585 pantoate-binding site; other site 935589002586 HXXH motif; other site 935589002587 TPR repeat; Region: TPR_11; pfam13414 935589002588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935589002589 binding surface 935589002590 TPR motif; other site 935589002591 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 935589002592 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 935589002593 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 935589002594 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 935589002595 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 935589002596 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 935589002597 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 935589002598 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589002599 active site 935589002600 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 935589002601 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 935589002602 5S rRNA interface [nucleotide binding]; other site 935589002603 CTC domain interface [polypeptide binding]; other site 935589002604 L16 interface [polypeptide binding]; other site 935589002605 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 935589002606 DNA methylase; Region: N6_N4_Mtase; pfam01555 935589002607 DNA methylase; Region: N6_N4_Mtase; cl17433 935589002608 Restriction endonuclease [Defense mechanisms]; Region: COG3587 935589002609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589002610 ATP binding site [chemical binding]; other site 935589002611 putative Mg++ binding site [ion binding]; other site 935589002612 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 935589002613 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 935589002614 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 935589002615 threonine dehydratase; Reviewed; Region: PRK09224 935589002616 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 935589002617 tetramer interface [polypeptide binding]; other site 935589002618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589002619 catalytic residue [active] 935589002620 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 935589002621 putative Ile/Val binding site [chemical binding]; other site 935589002622 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 935589002623 putative Ile/Val binding site [chemical binding]; other site 935589002624 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 935589002625 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 935589002626 Walker A/P-loop; other site 935589002627 ATP binding site [chemical binding]; other site 935589002628 Q-loop/lid; other site 935589002629 ABC transporter signature motif; other site 935589002630 Walker B; other site 935589002631 D-loop; other site 935589002632 H-loop/switch region; other site 935589002633 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935589002634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589002635 dimer interface [polypeptide binding]; other site 935589002636 conserved gate region; other site 935589002637 putative PBP binding loops; other site 935589002638 ABC-ATPase subunit interface; other site 935589002639 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 935589002640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589002641 dimer interface [polypeptide binding]; other site 935589002642 conserved gate region; other site 935589002643 putative PBP binding loops; other site 935589002644 ABC-ATPase subunit interface; other site 935589002645 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 935589002646 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 935589002647 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 935589002648 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 935589002649 replicative DNA helicase; Region: DnaB; TIGR00665 935589002650 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 935589002651 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 935589002652 Walker A motif; other site 935589002653 ATP binding site [chemical binding]; other site 935589002654 Walker B motif; other site 935589002655 DNA binding loops [nucleotide binding] 935589002656 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 935589002657 Type II transport protein GspH; Region: GspH; pfam12019 935589002658 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 935589002659 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 935589002660 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 935589002661 Tfp pilus assembly protein PilX [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilX; COG4726 935589002662 PilX N-terminal; Region: PilX_N; pfam14341 935589002663 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 935589002664 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 935589002665 Minor type IV pilin, PilX; Region: Pilin_PilX; pfam11530 935589002666 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 935589002667 trimer interface [polypeptide binding]; other site 935589002668 active site 935589002669 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 935589002670 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935589002671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589002672 homodimer interface [polypeptide binding]; other site 935589002673 catalytic residue [active] 935589002674 hypothetical protein; Validated; Region: PRK02101 935589002675 integrase; Provisional; Region: PRK09692 935589002676 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 935589002677 active site 935589002678 Int/Topo IB signature motif; other site 935589002679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 935589002680 KilA-N domain; Region: KilA-N; pfam04383 935589002681 Predicted helicase [General function prediction only]; Region: COG4889 935589002682 Uncharacterized conserved protein [Function unknown]; Region: COG5532 935589002683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935589002684 non-specific DNA binding site [nucleotide binding]; other site 935589002685 Predicted transcriptional regulator [Transcription]; Region: COG2932 935589002686 salt bridge; other site 935589002687 sequence-specific DNA binding site [nucleotide binding]; other site 935589002688 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935589002689 Catalytic site [active] 935589002690 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589002691 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589002692 Homeodomain-like domain; Region: HTH_32; pfam13565 935589002693 Integrase core domain; Region: rve; pfam00665 935589002694 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 935589002695 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 935589002696 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 935589002697 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 935589002698 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 935589002699 Monomeric isocitrate dehydrogenase; Region: IDH; pfam03971 935589002700 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 935589002701 Cytochrome C' Region: Cytochrom_C_2; cl01610 935589002702 malonic semialdehyde reductase; Provisional; Region: PRK10538 935589002703 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 935589002704 putative NAD(P) binding site [chemical binding]; other site 935589002705 homotetramer interface [polypeptide binding]; other site 935589002706 homodimer interface [polypeptide binding]; other site 935589002707 active site 935589002708 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 935589002709 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935589002710 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 935589002711 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 935589002712 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 935589002713 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 935589002714 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 935589002715 dimer interface [polypeptide binding]; other site 935589002716 active site 935589002717 catalytic residue [active] 935589002718 xanthine permease; Region: pbuX; TIGR03173 935589002719 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 935589002720 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 935589002721 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935589002722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 935589002723 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 935589002724 nucleoside/Zn binding site; other site 935589002725 dimer interface [polypeptide binding]; other site 935589002726 catalytic motif [active] 935589002727 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 935589002728 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 935589002729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 935589002730 conserved hypothetical protein, PP_1857 family; Region: efp_adjacent_2; TIGR03837 935589002731 elongation factor P; Validated; Region: PRK00529 935589002732 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 935589002733 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 935589002734 RNA binding site [nucleotide binding]; other site 935589002735 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 935589002736 RNA binding site [nucleotide binding]; other site 935589002737 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935589002738 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589002739 S-adenosylmethionine binding site [chemical binding]; other site 935589002740 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 935589002741 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 935589002742 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 935589002743 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 935589002744 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 935589002745 FAD binding site [chemical binding]; other site 935589002746 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 935589002747 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 935589002748 THF binding site; other site 935589002749 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 935589002750 substrate binding site [chemical binding]; other site 935589002751 THF binding site; other site 935589002752 zinc-binding site [ion binding]; other site 935589002753 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 935589002754 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 935589002755 catalytic triad [active] 935589002756 dimer interface [polypeptide binding]; other site 935589002757 Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029 935589002758 GSH binding site [chemical binding]; other site 935589002759 catalytic residues [active] 935589002760 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 935589002761 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935589002762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935589002763 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935589002764 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 935589002765 Iron-sulfur protein interface; other site 935589002766 proximal quinone binding site [chemical binding]; other site 935589002767 SdhD (CybS) interface [polypeptide binding]; other site 935589002768 proximal heme binding site [chemical binding]; other site 935589002769 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 935589002770 SdhC subunit interface [polypeptide binding]; other site 935589002771 proximal heme binding site [chemical binding]; other site 935589002772 cardiolipin binding site; other site 935589002773 Iron-sulfur protein interface; other site 935589002774 proximal quinone binding site [chemical binding]; other site 935589002775 succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816 935589002776 L-aspartate oxidase; Provisional; Region: PRK06175 935589002777 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935589002778 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 935589002779 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 935589002780 Uncharacterized conserved protein [Function unknown]; Region: COG2938 935589002781 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 935589002782 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935589002783 dimer interface [polypeptide binding]; other site 935589002784 active site 935589002785 citrylCoA binding site [chemical binding]; other site 935589002786 NADH binding [chemical binding]; other site 935589002787 cationic pore residues; other site 935589002788 oxalacetate/citrate binding site [chemical binding]; other site 935589002789 coenzyme A binding site [chemical binding]; other site 935589002790 catalytic triad [active] 935589002791 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 935589002792 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 935589002793 TPP-binding site [chemical binding]; other site 935589002794 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 935589002795 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 935589002796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935589002797 E3 interaction surface; other site 935589002798 lipoyl attachment site [posttranslational modification]; other site 935589002799 e3 binding domain; Region: E3_binding; pfam02817 935589002800 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935589002801 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 935589002802 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 935589002803 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935589002804 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935589002805 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 935589002806 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 935589002807 CoA-ligase; Region: Ligase_CoA; pfam00549 935589002808 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 935589002809 CoA binding domain; Region: CoA_binding; smart00881 935589002810 CoA-ligase; Region: Ligase_CoA; pfam00549 935589002811 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935589002812 Predicted transcriptional regulator [Transcription]; Region: COG2378 935589002813 WYL domain; Region: WYL; pfam13280 935589002814 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 935589002815 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 935589002816 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589002817 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 935589002818 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 935589002819 glutamine binding [chemical binding]; other site 935589002820 catalytic triad [active] 935589002821 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 935589002822 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 935589002823 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 935589002824 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935589002825 Replication initiation factor; Region: Rep_trans; pfam02486 935589002826 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935589002827 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935589002828 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 935589002829 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 935589002830 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 935589002831 MAPEG family; Region: MAPEG; cl09190 935589002832 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 935589002833 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 935589002834 ligand binding site [chemical binding]; other site 935589002835 homodimer interface [polypeptide binding]; other site 935589002836 NAD(P) binding site [chemical binding]; other site 935589002837 trimer interface B [polypeptide binding]; other site 935589002838 trimer interface A [polypeptide binding]; other site 935589002839 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 935589002840 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935589002841 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935589002842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589002843 motif II; other site 935589002844 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 935589002845 putative ion selectivity filter; other site 935589002846 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 935589002847 putative pore gating glutamate residue; other site 935589002848 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 935589002849 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 935589002850 purine monophosphate binding site [chemical binding]; other site 935589002851 dimer interface [polypeptide binding]; other site 935589002852 putative catalytic residues [active] 935589002853 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 935589002854 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 935589002855 Mu-like prophage protein gp16 [Function unknown]; Region: COG4382 935589002856 Mor transcription activator family; Region: Mor; cl02360 935589002857 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935589002858 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935589002859 active site 935589002860 metal binding site [ion binding]; metal-binding site 935589002861 Transposase domain (DUF772); Region: DUF772; pfam05598 935589002862 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589002863 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935589002864 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 935589002865 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 935589002866 YadA-like C-terminal region; Region: YadA; pfam03895 935589002867 Rubredoxin [Energy production and conversion]; Region: COG1773 935589002868 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 935589002869 iron binding site [ion binding]; other site 935589002870 Uncharacterized conserved protein [Function unknown]; Region: COG2128 935589002871 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 935589002872 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 935589002873 D-lactate dehydrogenase; Provisional; Region: PRK11183 935589002874 FAD binding domain; Region: FAD_binding_4; pfam01565 935589002875 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 935589002876 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 935589002877 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935589002878 FAD binding domain; Region: FAD_binding_4; pfam01565 935589002879 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935589002880 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 935589002881 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935589002882 Cysteine-rich domain; Region: CCG; pfam02754 935589002883 Cysteine-rich domain; Region: CCG; pfam02754 935589002884 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 935589002885 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 935589002886 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935589002887 FMN binding site [chemical binding]; other site 935589002888 active site 935589002889 catalytic residues [active] 935589002890 substrate binding site [chemical binding]; other site 935589002891 Transposase domain (DUF772); Region: DUF772; pfam05598 935589002892 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589002893 DDE superfamily endonuclease; Region: DDE_4; cl17710 935589002894 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 935589002895 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 935589002896 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 935589002897 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 935589002898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935589002899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935589002900 non-specific DNA binding site [nucleotide binding]; other site 935589002901 salt bridge; other site 935589002902 sequence-specific DNA binding site [nucleotide binding]; other site 935589002903 Predicted transcriptional regulator [Transcription]; Region: COG2932 935589002904 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935589002905 Catalytic site [active] 935589002906 Lysozyme family protein [General function prediction only]; Region: zliS; COG3926 935589002907 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 935589002908 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 935589002909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 935589002910 HTH-like domain; Region: HTH_21; pfam13276 935589002911 Integrase core domain; Region: rve; pfam00665 935589002912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 935589002913 Smr domain; Region: Smr; pfam01713 935589002914 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 935589002915 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 935589002916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 935589002917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 935589002918 Coenzyme A binding pocket [chemical binding]; other site 935589002919 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 935589002920 XdhC Rossmann domain; Region: XdhC_C; pfam13478 935589002921 ATP-grasp domain; Region: ATP-grasp; pfam02222 935589002922 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 935589002923 anthranilate synthase component I; Provisional; Region: PRK13565 935589002924 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 935589002925 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 935589002926 ABC transporter ATPase component; Reviewed; Region: PRK11147 935589002927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589002928 Walker A/P-loop; other site 935589002929 ATP binding site [chemical binding]; other site 935589002930 Q-loop/lid; other site 935589002931 ABC transporter signature motif; other site 935589002932 Walker B; other site 935589002933 D-loop; other site 935589002934 H-loop/switch region; other site 935589002935 ABC transporter; Region: ABC_tran_2; pfam12848 935589002936 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589002937 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 935589002938 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935589002939 Outer membrane protein OpcA; Region: OpcA; pfam07239 935589002940 Transposase domain (DUF772); Region: DUF772; pfam05598 935589002941 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589002942 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935589002943 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 935589002944 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 935589002945 dimer interface [polypeptide binding]; other site 935589002946 active site 935589002947 glycine-pyridoxal phosphate binding site [chemical binding]; other site 935589002948 folate binding site [chemical binding]; other site 935589002949 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 935589002950 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 935589002951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 935589002952 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 935589002953 AMP binding site [chemical binding]; other site 935589002954 metal binding site [ion binding]; metal-binding site 935589002955 active site 935589002956 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 935589002957 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 935589002958 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 935589002959 active site 935589002960 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 935589002961 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 935589002962 dimer interface [polypeptide binding]; other site 935589002963 ADP-ribose binding site [chemical binding]; other site 935589002964 active site 935589002965 nudix motif; other site 935589002966 metal binding site [ion binding]; metal-binding site 935589002967 camphor resistance protein CrcB; Provisional; Region: PRK14230 935589002968 Predicted membrane protein [Function unknown]; Region: COG3235 935589002969 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935589002970 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935589002971 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 935589002972 putative catalytic cysteine [active] 935589002973 glutamate 5-kinase; Region: proB; TIGR01027 935589002974 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 935589002975 nucleotide binding site [chemical binding]; other site 935589002976 homotetrameric interface [polypeptide binding]; other site 935589002977 putative phosphate binding site [ion binding]; other site 935589002978 putative allosteric binding site; other site 935589002979 PUA domain; Region: PUA; pfam01472 935589002980 2-isopropylmalate synthase; Validated; Region: PRK00915 935589002981 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 935589002982 active site 935589002983 catalytic residues [active] 935589002984 metal binding site [ion binding]; metal-binding site 935589002985 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 935589002986 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 935589002987 yecA family protein; Region: ygfB_yecA; TIGR02292 935589002988 SEC-C motif; Region: SEC-C; pfam02810 935589002989 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 935589002990 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 935589002991 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 935589002992 putative active site [active] 935589002993 Zn binding site [ion binding]; other site 935589002994 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 935589002995 feedback inhibition sensing region; other site 935589002996 homohexameric interface [polypeptide binding]; other site 935589002997 nucleotide binding site [chemical binding]; other site 935589002998 N-acetyl-L-glutamate binding site [chemical binding]; other site 935589002999 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 935589003000 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 935589003001 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 935589003002 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 935589003003 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 935589003004 ABC transporter; Region: ABC_tran; pfam00005 935589003005 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 935589003006 Integrase core domain; Region: rve; pfam00665 935589003007 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 935589003008 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 935589003009 AAA domain; Region: AAA_22; pfam13401 935589003010 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 935589003011 Mor transcription activator family; Region: Mor; cl02360 935589003012 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 935589003013 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935589003014 active site 935589003015 metal binding site [ion binding]; metal-binding site 935589003016 Uncharacterized conserved protein [Function unknown]; Region: COG3422 935589003017 Protein of unknown function (DUF1804); Region: DUF1804; pfam08822 935589003018 phage uncharacterized protein (putative large terminase), C-terminal domain; Region: psiM2_ORF9; TIGR01630 935589003019 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 935589003020 Protein of unknown function (DUF935); Region: DUF935; pfam06074 935589003021 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 935589003022 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 935589003023 Mu-like prophage protein gpG [General function prediction only]; Region: COG5005 935589003024 Mu-like prophage I protein [General function prediction only]; Region: COG4388 935589003025 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 935589003026 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 935589003027 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 935589003028 Mu-like prophage protein gp45 [Function unknown]; Region: COG4384 935589003029 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 935589003030 Mu-like prophage protein gp46 [Function unknown]; Region: COG4381 935589003031 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 935589003032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 935589003033 Phage Tail Collar Domain; Region: Collar; pfam07484 935589003034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3514 935589003035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 935589003036 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 935589003037 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 935589003038 Putative bacterial lipoprotein (DUF799); Region: DUF799; cl01813 935589003039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 935589003040 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 935589003041 short chain dehydrogenase; Provisional; Region: PRK08703 935589003042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 935589003043 NAD(P) binding site [chemical binding]; other site 935589003044 active site 935589003045 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 935589003046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 935589003047 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 935589003048 active site lid residues [active] 935589003049 substrate binding pocket [chemical binding]; other site 935589003050 catalytic residues [active] 935589003051 substrate-Mg2+ binding site; other site 935589003052 aspartate-rich region 1; other site 935589003053 aspartate-rich region 2; other site 935589003054 chaperone protein HscA; Provisional; Region: hscA; PRK05183 935589003055 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 935589003056 nucleotide binding site [chemical binding]; other site 935589003057 putative NEF/HSP70 interaction site [polypeptide binding]; other site 935589003058 SBD interface [polypeptide binding]; other site 935589003059 T5orf172 domain; Region: T5orf172; pfam10544 935589003060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 935589003061 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 935589003062 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 935589003063 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 935589003064 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 935589003065 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935589003066 catalytic loop [active] 935589003067 iron binding site [ion binding]; other site 935589003068 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 935589003069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589003070 RNA binding surface [nucleotide binding]; other site 935589003071 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 935589003072 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 935589003073 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 935589003074 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 935589003075 Ligand Binding Site [chemical binding]; other site 935589003076 TilS substrate binding domain; Region: TilS; pfam09179 935589003077 TilS substrate C-terminal domain; Region: TilS_C; cl17443 935589003078 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 935589003079 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 935589003080 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 935589003081 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935589003082 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935589003083 biotin synthase; Region: bioB; TIGR00433 935589003084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589003085 FeS/SAM binding site; other site 935589003086 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 935589003087 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 935589003088 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 935589003089 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 935589003090 sulfite reductase subunit beta; Provisional; Region: PRK13504 935589003091 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935589003092 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 935589003093 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 935589003094 Flavodoxin; Region: Flavodoxin_1; pfam00258 935589003095 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 935589003096 FAD binding pocket [chemical binding]; other site 935589003097 FAD binding motif [chemical binding]; other site 935589003098 catalytic residues [active] 935589003099 NAD binding pocket [chemical binding]; other site 935589003100 phosphate binding motif [ion binding]; other site 935589003101 beta-alpha-beta structure motif; other site 935589003102 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 935589003103 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 935589003104 CysD dimerization site [polypeptide binding]; other site 935589003105 G1 box; other site 935589003106 putative GEF interaction site [polypeptide binding]; other site 935589003107 GTP/Mg2+ binding site [chemical binding]; other site 935589003108 Switch I region; other site 935589003109 G2 box; other site 935589003110 G3 box; other site 935589003111 Switch II region; other site 935589003112 G4 box; other site 935589003113 G5 box; other site 935589003114 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 935589003115 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 935589003116 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 935589003117 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 935589003118 Active Sites [active] 935589003119 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 935589003120 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 935589003121 Active Sites [active] 935589003122 siroheme synthase; Provisional; Region: cysG; PRK10637 935589003123 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 935589003124 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 935589003125 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 935589003126 active site 935589003127 SAM binding site [chemical binding]; other site 935589003128 homodimer interface [polypeptide binding]; other site 935589003129 Cytochrome b [Energy production and conversion]; Region: COG3658 935589003130 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 935589003131 putative substrate binding site [chemical binding]; other site 935589003132 putative ATP binding site [chemical binding]; other site 935589003133 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 935589003134 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 935589003135 G1 box; other site 935589003136 putative GEF interaction site [polypeptide binding]; other site 935589003137 GTP/Mg2+ binding site [chemical binding]; other site 935589003138 Switch I region; other site 935589003139 G2 box; other site 935589003140 G3 box; other site 935589003141 Switch II region; other site 935589003142 G4 box; other site 935589003143 G5 box; other site 935589003144 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 935589003145 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 935589003146 ribonuclease R; Region: RNase_R; TIGR02063 935589003147 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 935589003148 RNB domain; Region: RNB; pfam00773 935589003149 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 935589003150 RNA binding site [nucleotide binding]; other site 935589003151 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 935589003152 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935589003153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 935589003154 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 935589003155 active site 935589003156 UTP:GlnB (protein PII) uridylyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: GlnD; COG2844 935589003157 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 935589003158 metal binding triad; other site 935589003159 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 935589003160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935589003161 Zn2+ binding site [ion binding]; other site 935589003162 Mg2+ binding site [ion binding]; other site 935589003163 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 935589003164 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 935589003165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 935589003166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935589003167 non-specific DNA binding site [nucleotide binding]; other site 935589003168 salt bridge; other site 935589003169 sequence-specific DNA binding site [nucleotide binding]; other site 935589003170 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 935589003171 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 935589003172 heme binding site [chemical binding]; other site 935589003173 ferroxidase pore; other site 935589003174 ferroxidase diiron center [ion binding]; other site 935589003175 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 935589003176 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 935589003177 heme binding site [chemical binding]; other site 935589003178 ferroxidase pore; other site 935589003179 ferroxidase diiron center [ion binding]; other site 935589003180 lipoyl synthase; Provisional; Region: PRK05481 935589003181 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589003182 FeS/SAM binding site; other site 935589003183 lipoate-protein ligase B; Provisional; Region: PRK14342 935589003184 Uncharacterized conserved protein [Function unknown]; Region: COG2921 935589003185 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 935589003186 Domain of unknown function DUF20; Region: UPF0118; pfam01594 935589003187 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 935589003188 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 935589003189 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 935589003190 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 935589003191 ligand binding site [chemical binding]; other site 935589003192 active site 935589003193 UGI interface [polypeptide binding]; other site 935589003194 catalytic site [active] 935589003195 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 935589003196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589003197 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589003198 ABC transporter; Region: ABC_tran_2; pfam12848 935589003199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589003200 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 935589003201 homoserine dehydrogenase; Provisional; Region: PRK06349 935589003202 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 935589003203 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 935589003204 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 935589003205 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935589003206 IHF dimer interface [polypeptide binding]; other site 935589003207 IHF - DNA interface [nucleotide binding]; other site 935589003208 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 935589003209 Found in ATP-dependent protease La (LON); Region: LON; smart00464 935589003210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589003211 Walker A motif; other site 935589003212 ATP binding site [chemical binding]; other site 935589003213 Walker B motif; other site 935589003214 arginine finger; other site 935589003215 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 935589003216 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935589003217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589003218 S-adenosylmethionine binding site [chemical binding]; other site 935589003219 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 935589003220 AAA domain; Region: AAA_30; pfam13604 935589003221 Family description; Region: UvrD_C_2; pfam13538 935589003222 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 935589003223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 935589003224 Walker A/P-loop; other site 935589003225 ATP binding site [chemical binding]; other site 935589003226 Q-loop/lid; other site 935589003227 ABC transporter signature motif; other site 935589003228 Walker B; other site 935589003229 D-loop; other site 935589003230 H-loop/switch region; other site 935589003231 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 935589003232 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 935589003233 FtsX-like permease family; Region: FtsX; pfam02687 935589003234 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 935589003235 RecR protein; Region: RecR; pfam02132 935589003236 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 935589003237 putative active site [active] 935589003238 putative metal-binding site [ion binding]; other site 935589003239 tetramer interface [polypeptide binding]; other site 935589003240 SurA N-terminal domain; Region: SurA_N_3; cl07813 935589003241 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 935589003242 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935589003243 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 935589003244 ArsC family; Region: ArsC; pfam03960 935589003245 putative catalytic residues [active] 935589003246 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 935589003247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589003248 Walker A/P-loop; other site 935589003249 ATP binding site [chemical binding]; other site 935589003250 ABC transporter signature motif; other site 935589003251 Walker B; other site 935589003252 D-loop; other site 935589003253 H-loop/switch region; other site 935589003254 ABC transporter; Region: ABC_tran_2; pfam12848 935589003255 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589003256 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 935589003257 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 935589003258 active site 935589003259 NTP binding site [chemical binding]; other site 935589003260 metal binding triad [ion binding]; metal-binding site 935589003261 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 935589003262 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935589003263 Zn2+ binding site [ion binding]; other site 935589003264 Mg2+ binding site [ion binding]; other site 935589003265 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 935589003266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589003267 Walker A motif; other site 935589003268 ATP binding site [chemical binding]; other site 935589003269 Walker B motif; other site 935589003270 arginine finger; other site 935589003271 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 935589003272 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 935589003273 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 935589003274 substrate binding site [chemical binding]; other site 935589003275 hexamer interface [polypeptide binding]; other site 935589003276 metal binding site [ion binding]; metal-binding site 935589003277 P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678 935589003278 dimer interface [polypeptide binding]; other site 935589003279 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 935589003280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589003281 Walker A motif; other site 935589003282 ATP binding site [chemical binding]; other site 935589003283 Walker B motif; other site 935589003284 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 935589003285 Lumazine binding domain; Region: Lum_binding; pfam00677 935589003286 Lumazine binding domain; Region: Lum_binding; pfam00677 935589003287 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 935589003288 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 935589003289 GTP binding site; other site 935589003290 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 935589003291 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 935589003292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 935589003293 dimerization interface [polypeptide binding]; other site 935589003294 Histidine kinase; Region: HisKA_3; pfam07730 935589003295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589003296 ATP binding site [chemical binding]; other site 935589003297 Mg2+ binding site [ion binding]; other site 935589003298 G-X-G motif; other site 935589003299 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 935589003300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935589003301 active site 935589003302 phosphorylation site [posttranslational modification] 935589003303 intermolecular recognition site; other site 935589003304 dimerization interface [polypeptide binding]; other site 935589003305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 935589003306 DNA binding residues [nucleotide binding] 935589003307 dimerization interface [polypeptide binding]; other site 935589003308 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 935589003309 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 935589003310 dimerization interface [polypeptide binding]; other site 935589003311 putative ATP binding site [chemical binding]; other site 935589003312 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 935589003313 dimerization interface [polypeptide binding]; other site 935589003314 active site 935589003315 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 935589003316 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 935589003317 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 935589003318 dimerization interface [polypeptide binding]; other site 935589003319 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 935589003320 recombination factor protein RarA; Reviewed; Region: PRK13342 935589003321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589003322 Walker A motif; other site 935589003323 ATP binding site [chemical binding]; other site 935589003324 Walker B motif; other site 935589003325 arginine finger; other site 935589003326 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 935589003327 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589003328 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589003329 Homeodomain-like domain; Region: HTH_32; pfam13565 935589003330 Integrase core domain; Region: rve; pfam00665 935589003331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 935589003332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935589003333 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 935589003334 dimerization interface [polypeptide binding]; other site 935589003335 Protein of unknown function (DUF3360); Region: DUF3360; pfam11840 935589003336 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 935589003337 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 935589003338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589003339 catalytic residue [active] 935589003340 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 935589003341 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 935589003342 FAD binding pocket [chemical binding]; other site 935589003343 FAD binding motif [chemical binding]; other site 935589003344 phosphate binding motif [ion binding]; other site 935589003345 beta-alpha-beta structure motif; other site 935589003346 NAD binding pocket [chemical binding]; other site 935589003347 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 935589003348 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935589003349 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935589003350 metal-binding site [ion binding] 935589003351 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935589003352 Soluble P-type ATPase [General function prediction only]; Region: COG4087 935589003353 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 935589003354 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 935589003355 HflX GTPase family; Region: HflX; cd01878 935589003356 G1 box; other site 935589003357 GTP/Mg2+ binding site [chemical binding]; other site 935589003358 Switch I region; other site 935589003359 G2 box; other site 935589003360 G3 box; other site 935589003361 Switch II region; other site 935589003362 G4 box; other site 935589003363 G5 box; other site 935589003364 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 935589003365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 935589003366 hypothetical protein; Reviewed; Region: PRK00024 935589003367 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 935589003368 MPN+ (JAMM) motif; other site 935589003369 Zinc-binding site [ion binding]; other site 935589003370 Glutamate-cysteine ligase; Region: GshA; pfam08886 935589003371 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 935589003372 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 935589003373 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 935589003374 substrate binding site [chemical binding]; other site 935589003375 ligand binding site [chemical binding]; other site 935589003376 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 935589003377 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 935589003378 substrate binding site [chemical binding]; other site 935589003379 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589003380 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935589003381 cofactor binding site; other site 935589003382 DNA binding site [nucleotide binding] 935589003383 substrate interaction site [chemical binding]; other site 935589003384 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589003385 NgoBV restriction endonuclease; Region: RE_NgoBV; pfam09564 935589003386 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 935589003387 tartrate dehydrogenase; Region: TTC; TIGR02089 935589003388 Uncharacterized conserved protein [Function unknown]; Region: COG2353 935589003389 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 935589003390 Aspartase; Region: Aspartase; cd01357 935589003391 active sites [active] 935589003392 tetramer interface [polypeptide binding]; other site 935589003393 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 935589003394 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935589003395 HSP70 interaction site [polypeptide binding]; other site 935589003396 Predicted membrane protein [Function unknown]; Region: COG3671 935589003397 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 935589003398 putative deacylase active site [active] 935589003399 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 935589003400 homotrimer interaction site [polypeptide binding]; other site 935589003401 putative active site [active] 935589003402 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 935589003403 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 935589003404 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 935589003405 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 935589003406 Ligand Binding Site [chemical binding]; other site 935589003407 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 935589003408 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 935589003409 DNA methylase; Region: N6_N4_Mtase; pfam01555 935589003410 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 935589003411 substrate binding site [chemical binding]; other site 935589003412 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 935589003413 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 935589003414 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 935589003415 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 935589003416 metal binding site 2 [ion binding]; metal-binding site 935589003417 putative DNA binding helix; other site 935589003418 metal binding site 1 [ion binding]; metal-binding site 935589003419 dimer interface [polypeptide binding]; other site 935589003420 structural Zn2+ binding site [ion binding]; other site 935589003421 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 935589003422 Low molecular weight phosphatase family; Region: LMWPc; cd00115 935589003423 active site 935589003424 glycerate kinase; Region: TIGR00045 935589003425 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 935589003426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589003427 S-adenosylmethionine binding site [chemical binding]; other site 935589003428 Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797 935589003429 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935589003430 metal-binding site [ion binding] 935589003431 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 935589003432 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 935589003433 active site 935589003434 catalytic triad [active] 935589003435 oxyanion hole [active] 935589003436 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 935589003437 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 935589003438 active site 935589003439 oxyanion hole [active] 935589003440 catalytic triad [active] 935589003441 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 935589003442 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935589003443 acyl-activating enzyme (AAE) consensus motif; other site 935589003444 putative AMP binding site [chemical binding]; other site 935589003445 putative active site [active] 935589003446 putative CoA binding site [chemical binding]; other site 935589003447 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 935589003448 Site-specific recombinase [DNA replication, recombination, and repair]; Region: COG4389 935589003449 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 935589003450 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935589003451 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935589003452 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 935589003453 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 935589003454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 935589003455 active site 935589003456 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 935589003457 DEAD-like helicases superfamily; Region: DEXDc; smart00487 935589003458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589003459 ATP binding site [chemical binding]; other site 935589003460 putative Mg++ binding site [ion binding]; other site 935589003461 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935589003462 nucleotide binding region [chemical binding]; other site 935589003463 ATP-binding site [chemical binding]; other site 935589003464 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 935589003465 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 935589003466 tetramerization interface [polypeptide binding]; other site 935589003467 active site 935589003468 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 935589003469 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 935589003470 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 935589003471 enolase; Provisional; Region: eno; PRK00077 935589003472 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 935589003473 dimer interface [polypeptide binding]; other site 935589003474 metal binding site [ion binding]; metal-binding site 935589003475 substrate binding pocket [chemical binding]; other site 935589003476 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 935589003477 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 935589003478 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 935589003479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935589003480 catalytic loop [active] 935589003481 iron binding site [ion binding]; other site 935589003482 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 935589003483 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 935589003484 dimer interface [polypeptide binding]; other site 935589003485 putative radical transfer pathway; other site 935589003486 diiron center [ion binding]; other site 935589003487 tyrosyl radical; other site 935589003488 N-terminal domain of type IIE restriction endonuclease EcoRII and similar proteins; Region: EcoRII_N; cd10016 935589003489 DNA binding site [nucleotide binding] 935589003490 EcoRII C terminal; Region: EcoRII-C; pfam09019 935589003491 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589003492 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 935589003493 cofactor binding site; other site 935589003494 DNA binding site [nucleotide binding] 935589003495 substrate interaction site [chemical binding]; other site 935589003496 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 935589003497 ATP cone domain; Region: ATP-cone; pfam03477 935589003498 Class I ribonucleotide reductase; Region: RNR_I; cd01679 935589003499 active site 935589003500 dimer interface [polypeptide binding]; other site 935589003501 catalytic residues [active] 935589003502 effector binding site; other site 935589003503 R2 peptide binding site; other site 935589003504 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935589003505 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935589003506 putative acyl-acceptor binding pocket; other site 935589003507 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 935589003508 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 935589003509 DNA binding site [nucleotide binding] 935589003510 catalytic residue [active] 935589003511 H2TH interface [polypeptide binding]; other site 935589003512 putative catalytic residues [active] 935589003513 turnover-facilitating residue; other site 935589003514 intercalation triad [nucleotide binding]; other site 935589003515 8OG recognition residue [nucleotide binding]; other site 935589003516 putative reading head residues; other site 935589003517 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 935589003518 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 935589003519 Methyltransferase domain; Region: Methyltransf_23; pfam13489 935589003520 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935589003521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935589003522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935589003523 catalytic residue [active] 935589003524 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935589003525 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 935589003526 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935589003527 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935589003528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 935589003529 RNA binding surface [nucleotide binding]; other site 935589003530 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 935589003531 active site 935589003532 uracil binding [chemical binding]; other site 935589003533 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 935589003534 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 935589003535 CMP-binding site; other site 935589003536 The sites determining sugar specificity; other site 935589003537 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 935589003538 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 935589003539 RNA binding site [nucleotide binding]; other site 935589003540 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 935589003541 RNA binding site [nucleotide binding]; other site 935589003542 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 935589003543 RNA binding site [nucleotide binding]; other site 935589003544 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 935589003545 RNA binding site [nucleotide binding]; other site 935589003546 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 935589003547 RNA binding site [nucleotide binding]; other site 935589003548 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 935589003549 RNA binding site [nucleotide binding]; other site 935589003550 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 935589003551 IHF dimer interface [polypeptide binding]; other site 935589003552 IHF - DNA interface [nucleotide binding]; other site 935589003553 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 935589003554 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 935589003555 DNA binding residues [nucleotide binding] 935589003556 putative dimer interface [polypeptide binding]; other site 935589003557 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 935589003558 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 935589003559 substrate binding site [chemical binding]; other site 935589003560 catalytic Zn binding site [ion binding]; other site 935589003561 NAD binding site [chemical binding]; other site 935589003562 structural Zn binding site [ion binding]; other site 935589003563 dimer interface [polypeptide binding]; other site 935589003564 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 935589003565 S-formylglutathione hydrolase; Region: PLN02442 935589003566 Predicted ATPase [General function prediction only]; Region: COG1485 935589003567 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 935589003568 active site 935589003569 multimer interface [polypeptide binding]; other site 935589003570 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 935589003571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589003572 FeS/SAM binding site; other site 935589003573 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 935589003574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935589003575 binding surface 935589003576 TPR motif; other site 935589003577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935589003578 TPR motif; other site 935589003579 binding surface 935589003580 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 935589003581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935589003582 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 935589003583 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 935589003584 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 935589003585 oligomer interface [polypeptide binding]; other site 935589003586 active site residues [active] 935589003587 trigger factor; Provisional; Region: tig; PRK01490 935589003588 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935589003589 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 935589003590 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 935589003591 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 935589003592 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 935589003593 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 935589003594 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 935589003595 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 935589003596 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 935589003597 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935589003598 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 935589003599 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 935589003600 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 935589003601 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 935589003602 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 935589003603 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 935589003604 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 935589003605 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935589003606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935589003607 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 935589003608 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 935589003609 metal-binding site [ion binding] 935589003610 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 935589003611 Soluble P-type ATPase [General function prediction only]; Region: COG4087 935589003612 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 935589003613 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 935589003614 GIY-YIG motif/motif A; other site 935589003615 active site 935589003616 catalytic site [active] 935589003617 putative DNA binding site [nucleotide binding]; other site 935589003618 metal binding site [ion binding]; metal-binding site 935589003619 UvrB/uvrC motif; Region: UVR; pfam02151 935589003620 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 935589003621 Helix-hairpin-helix motif; Region: HHH; pfam00633 935589003622 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935589003623 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935589003624 Sel1-like repeats; Region: SEL1; smart00671 935589003625 Sel1-like repeats; Region: SEL1; smart00671 935589003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589003627 S-adenosylmethionine binding site [chemical binding]; other site 935589003628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935589003629 beta-amyloid precursor protein C-terminus; Region: APP_amyloid; pfam10515 935589003630 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 935589003631 excinuclease ABC subunit B; Provisional; Region: PRK05298 935589003632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 935589003633 ATP-binding site [chemical binding]; other site 935589003634 ATP binding site [chemical binding]; other site 935589003635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935589003636 nucleotide binding region [chemical binding]; other site 935589003637 ATP-binding site [chemical binding]; other site 935589003638 Ultra-violet resistance protein B; Region: UvrB; pfam12344 935589003639 UvrB/uvrC motif; Region: UVR; pfam02151 935589003640 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 935589003641 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 935589003642 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 935589003643 protein binding site [polypeptide binding]; other site 935589003644 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 935589003645 Catalytic dyad [active] 935589003646 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 935589003647 Peptidase family M23; Region: Peptidase_M23; pfam01551 935589003648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 935589003649 CreA protein; Region: CreA; pfam05981 935589003650 Putative transcriptional regulator [Transcription]; Region: COG1678 935589003651 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 935589003652 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 935589003653 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 935589003654 prolyl-tRNA synthetase; Provisional; Region: PRK09194 935589003655 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 935589003656 dimer interface [polypeptide binding]; other site 935589003657 motif 1; other site 935589003658 active site 935589003659 motif 2; other site 935589003660 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 935589003661 putative deacylase active site [active] 935589003662 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 935589003663 active site 935589003664 motif 3; other site 935589003665 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 935589003666 anticodon binding site; other site 935589003667 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 935589003668 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 935589003669 dimer interface [polypeptide binding]; other site 935589003670 TPP-binding site [chemical binding]; other site 935589003671 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 935589003672 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935589003673 E3 interaction surface; other site 935589003674 lipoyl attachment site [posttranslational modification]; other site 935589003675 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935589003676 E3 interaction surface; other site 935589003677 lipoyl attachment site [posttranslational modification]; other site 935589003678 e3 binding domain; Region: E3_binding; pfam02817 935589003679 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 935589003680 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 935589003681 E3 interaction surface; other site 935589003682 lipoyl attachment site [posttranslational modification]; other site 935589003683 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 935589003684 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 935589003685 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 935589003686 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 935589003687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 935589003688 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 935589003689 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 935589003690 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935589003691 N-terminal plug; other site 935589003692 ligand-binding site [chemical binding]; other site 935589003693 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 935589003694 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 935589003695 active site 935589003696 dimerization interface [polypeptide binding]; other site 935589003697 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 935589003698 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 935589003699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3782 935589003700 16S rRNA methyltransferase B; Provisional; Region: PRK10901 935589003701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589003702 S-adenosylmethionine binding site [chemical binding]; other site 935589003703 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 935589003704 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 935589003705 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 935589003706 NAD(P) binding site [chemical binding]; other site 935589003707 catalytic residues [active] 935589003708 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 935589003709 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 935589003710 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 935589003711 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 935589003712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VirK; COG2990 935589003713 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 935589003714 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 935589003715 GatB domain; Region: GatB_Yqey; smart00845 935589003716 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 935589003717 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 935589003718 catalytic loop [active] 935589003719 iron binding site [ion binding]; other site 935589003720 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 935589003721 FAD binding pocket [chemical binding]; other site 935589003722 FAD binding motif [chemical binding]; other site 935589003723 phosphate binding motif [ion binding]; other site 935589003724 beta-alpha-beta structure motif; other site 935589003725 NAD binding pocket [chemical binding]; other site 935589003726 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 935589003727 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 935589003728 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 935589003729 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 935589003730 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 935589003731 RNA binding surface [nucleotide binding]; other site 935589003732 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 935589003733 probable active site [active] 935589003734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589003735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935589003736 putative substrate translocation pore; other site 935589003737 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 935589003738 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 935589003739 generic binding surface II; other site 935589003740 generic binding surface I; other site 935589003741 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 935589003742 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 935589003743 homodimer interface [polypeptide binding]; other site 935589003744 NAD binding pocket [chemical binding]; other site 935589003745 ATP binding pocket [chemical binding]; other site 935589003746 Mg binding site [ion binding]; other site 935589003747 active-site loop [active] 935589003748 Hemerythrin-like domain; Region: Hr-like; cd12108 935589003749 Fe binding site [ion binding]; other site 935589003750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 935589003751 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935589003752 catalytic residues [active] 935589003753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589003754 S-adenosylmethionine binding site [chemical binding]; other site 935589003755 helicase 45; Provisional; Region: PTZ00424 935589003756 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935589003757 ATP binding site [chemical binding]; other site 935589003758 Mg++ binding site [ion binding]; other site 935589003759 motif III; other site 935589003760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935589003761 nucleotide binding region [chemical binding]; other site 935589003762 ATP-binding site [chemical binding]; other site 935589003763 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 935589003764 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 935589003765 inhibitor-cofactor binding pocket; inhibition site 935589003766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589003767 catalytic residue [active] 935589003768 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 935589003769 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 935589003770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589003771 Walker A motif; other site 935589003772 ATP binding site [chemical binding]; other site 935589003773 Walker B motif; other site 935589003774 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 935589003775 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 935589003776 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 935589003777 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 935589003778 RNA binding site [nucleotide binding]; other site 935589003779 active site 935589003780 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 935589003781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 935589003782 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 935589003783 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935589003784 phosphate binding site [ion binding]; other site 935589003785 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 935589003786 Rrf2 family protein; Region: rrf2_super; TIGR00738 935589003787 cysteine desulfurase; Provisional; Region: PRK14012 935589003788 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 935589003789 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 935589003790 catalytic residue [active] 935589003791 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 935589003792 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 935589003793 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 935589003794 trimerization site [polypeptide binding]; other site 935589003795 active site 935589003796 iron-sulfur cluster assembly protein IscA; Region: IscA; TIGR02011 935589003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 935589003798 co-chaperone HscB; Provisional; Region: hscB; PRK03578 935589003799 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 935589003800 HSP70 interaction site [polypeptide binding]; other site 935589003801 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 935589003802 DNA gyrase subunit A; Validated; Region: PRK05560 935589003803 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935589003804 CAP-like domain; other site 935589003805 active site 935589003806 primary dimer interface [polypeptide binding]; other site 935589003807 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935589003808 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935589003809 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935589003810 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935589003811 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 935589003812 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935589003813 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935589003814 active site 935589003815 dimer interface [polypeptide binding]; other site 935589003816 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935589003817 dimer interface [polypeptide binding]; other site 935589003818 active site 935589003819 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 935589003820 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 935589003821 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 935589003822 putative active site [active] 935589003823 glucokinase; Provisional; Region: glk; PRK00292 935589003824 glucokinase, proteobacterial type; Region: glk; TIGR00749 935589003825 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 935589003826 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 935589003827 putative active site [active] 935589003828 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 935589003829 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 935589003830 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 935589003831 phosphogluconate dehydratase; Validated; Region: PRK09054 935589003832 6-phosphogluconate dehydratase; Region: edd; TIGR01196 935589003833 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 935589003834 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 935589003835 active site 935589003836 intersubunit interface [polypeptide binding]; other site 935589003837 catalytic residue [active] 935589003838 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 935589003839 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 935589003840 minor groove reading motif; other site 935589003841 helix-hairpin-helix signature motif; other site 935589003842 substrate binding pocket [chemical binding]; other site 935589003843 active site 935589003844 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 935589003845 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 935589003846 DNA binding and oxoG recognition site [nucleotide binding] 935589003847 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 935589003848 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 935589003849 E-class dimer interface [polypeptide binding]; other site 935589003850 P-class dimer interface [polypeptide binding]; other site 935589003851 active site 935589003852 Cu2+ binding site [ion binding]; other site 935589003853 Zn2+ binding site [ion binding]; other site 935589003854 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 935589003855 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 935589003856 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 935589003857 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 935589003858 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 935589003859 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 935589003860 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 935589003861 Walker A/P-loop; other site 935589003862 ATP binding site [chemical binding]; other site 935589003863 Q-loop/lid; other site 935589003864 ABC transporter signature motif; other site 935589003865 Walker B; other site 935589003866 D-loop; other site 935589003867 H-loop/switch region; other site 935589003868 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589003869 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 935589003870 aminopeptidase N; Provisional; Region: pepN; PRK14015 935589003871 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 935589003872 active site 935589003873 Zn binding site [ion binding]; other site 935589003874 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 935589003875 active site 935589003876 catalytic site [active] 935589003877 substrate binding site [chemical binding]; other site 935589003878 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 935589003879 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 935589003880 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 935589003881 putative acyl-acceptor binding pocket; other site 935589003882 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 935589003883 active site 935589003884 putative DNA-binding cleft [nucleotide binding]; other site 935589003885 dimer interface [polypeptide binding]; other site 935589003886 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 935589003887 DNA-binding protein Fis; Provisional; Region: PRK01905 935589003888 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 935589003889 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935589003890 FMN binding site [chemical binding]; other site 935589003891 active site 935589003892 catalytic residues [active] 935589003893 substrate binding site [chemical binding]; other site 935589003894 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 935589003895 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 935589003896 ATP binding site [chemical binding]; other site 935589003897 Mg++ binding site [ion binding]; other site 935589003898 motif III; other site 935589003899 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 935589003900 nucleotide binding region [chemical binding]; other site 935589003901 ATP-binding site [chemical binding]; other site 935589003902 Fic family protein [Function unknown]; Region: COG3177 935589003903 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 935589003904 Fic/DOC family; Region: Fic; pfam02661 935589003905 Protein of unknown function (DUF723); Region: DUF723; pfam05265 935589003906 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 935589003907 Catalytic site [active] 935589003908 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 935589003909 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 935589003910 dimer interface [polypeptide binding]; other site 935589003911 putative anticodon binding site; other site 935589003912 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 935589003913 motif 1; other site 935589003914 active site 935589003915 motif 2; other site 935589003916 motif 3; other site 935589003917 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 935589003918 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935589003919 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 935589003920 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 935589003921 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 935589003922 active site 935589003923 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 935589003924 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 935589003925 eyelet of channel; other site 935589003926 trimer interface [polypeptide binding]; other site 935589003927 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 935589003928 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 935589003929 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 935589003930 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 935589003931 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 935589003932 hinge; other site 935589003933 active site 935589003934 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 935589003935 NlpC/P60 family; Region: NLPC_P60; pfam00877 935589003936 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 935589003937 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 935589003938 putative active site [active] 935589003939 catalytic site [active] 935589003940 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 935589003941 putative active site [active] 935589003942 catalytic site [active] 935589003943 putative transporter; Provisional; Region: PRK10504 935589003944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589003945 putative substrate translocation pore; other site 935589003946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589003947 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 935589003948 Cysteine-rich domain; Region: CCG; pfam02754 935589003949 Cysteine-rich domain; Region: CCG; pfam02754 935589003950 Uncharacterized conserved protein [Function unknown]; Region: COG1556 935589003951 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 935589003952 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 935589003953 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 935589003954 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 935589003955 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 935589003956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 935589003957 Tetratricopeptide repeat; Region: TPR_6; pfam13174 935589003958 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 935589003959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589003960 S-adenosylmethionine binding site [chemical binding]; other site 935589003961 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 935589003962 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 935589003963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589003964 ATP binding site [chemical binding]; other site 935589003965 Mg2+ binding site [ion binding]; other site 935589003966 G-X-G motif; other site 935589003967 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 935589003968 ATP binding site [chemical binding]; other site 935589003969 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 935589003970 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 935589003971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589003972 Walker A motif; other site 935589003973 ATP binding site [chemical binding]; other site 935589003974 Walker B motif; other site 935589003975 arginine finger; other site 935589003976 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 935589003977 hypothetical protein; Validated; Region: PRK00153 935589003978 recombinase A; Provisional; Region: recA; PRK09354 935589003979 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 935589003980 hexamer interface [polypeptide binding]; other site 935589003981 Walker A motif; other site 935589003982 ATP binding site [chemical binding]; other site 935589003983 Walker B motif; other site 935589003984 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 935589003985 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 935589003986 active site 935589003987 catalytic residue [active] 935589003988 dimer interface [polypeptide binding]; other site 935589003989 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 935589003990 Family description; Region: UvrD_C_2; pfam13538 935589003991 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 935589003992 active site 935589003993 DNA polymerase IV; Validated; Region: PRK02406 935589003994 DNA binding site [nucleotide binding] 935589003995 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589003996 Transposase domain (DUF772); Region: DUF772; pfam05598 935589003997 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589003998 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935589003999 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 935589004000 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 935589004001 FAD binding pocket [chemical binding]; other site 935589004002 FAD binding motif [chemical binding]; other site 935589004003 phosphate binding motif [ion binding]; other site 935589004004 beta-alpha-beta structure motif; other site 935589004005 NAD binding pocket [chemical binding]; other site 935589004006 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 935589004007 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 935589004008 active site 935589004009 catalytic site [active] 935589004010 substrate binding site [chemical binding]; other site 935589004011 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 935589004012 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 935589004013 FMN binding site [chemical binding]; other site 935589004014 substrate binding site [chemical binding]; other site 935589004015 putative catalytic residue [active] 935589004016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198 935589004017 FixH; Region: FixH; pfam05751 935589004018 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 935589004019 4Fe-4S binding domain; Region: Fer4_5; pfam12801 935589004020 4Fe-4S binding domain; Region: Fer4_3; pfam12798 935589004021 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 935589004022 transketolase; Reviewed; Region: PRK12753 935589004023 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 935589004024 TPP-binding site [chemical binding]; other site 935589004025 dimer interface [polypeptide binding]; other site 935589004026 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 935589004027 PYR/PP interface [polypeptide binding]; other site 935589004028 dimer interface [polypeptide binding]; other site 935589004029 TPP binding site [chemical binding]; other site 935589004030 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 935589004031 fumarate hydratase; Reviewed; Region: fumC; PRK00485 935589004032 Class II fumarases; Region: Fumarase_classII; cd01362 935589004033 active site 935589004034 tetramer interface [polypeptide binding]; other site 935589004035 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935589004036 EamA-like transporter family; Region: EamA; pfam00892 935589004037 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 935589004038 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 935589004039 dimer interface [polypeptide binding]; other site 935589004040 ssDNA binding site [nucleotide binding]; other site 935589004041 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935589004042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589004043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935589004044 putative substrate translocation pore; other site 935589004045 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 935589004046 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 935589004047 N-acetyl-D-glucosamine binding site [chemical binding]; other site 935589004048 catalytic residue [active] 935589004049 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 935589004050 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935589004051 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 935589004052 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 935589004053 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 935589004054 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 935589004055 active site 935589004056 HIGH motif; other site 935589004057 dimer interface [polypeptide binding]; other site 935589004058 KMSKS motif; other site 935589004059 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 935589004060 Clp amino terminal domain; Region: Clp_N; pfam02861 935589004061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589004062 Walker A motif; other site 935589004063 ATP binding site [chemical binding]; other site 935589004064 Walker B motif; other site 935589004065 arginine finger; other site 935589004066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 935589004067 Walker A motif; other site 935589004068 ATP binding site [chemical binding]; other site 935589004069 Walker B motif; other site 935589004070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 935589004071 aminotransferase AlaT; Validated; Region: PRK09265 935589004072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935589004073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004074 homodimer interface [polypeptide binding]; other site 935589004075 catalytic residue [active] 935589004076 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 935589004077 active site 1 [active] 935589004078 dimer interface [polypeptide binding]; other site 935589004079 hexamer interface [polypeptide binding]; other site 935589004080 active site 2 [active] 935589004081 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 935589004082 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 935589004083 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935589004084 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 935589004085 NAD(P) binding site [chemical binding]; other site 935589004086 phosphoglycolate phosphatase; Provisional; Region: PRK13222 935589004087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589004088 motif II; other site 935589004089 recombination regulator RecX; Reviewed; Region: recX; PRK00117 935589004090 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 935589004091 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935589004092 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935589004093 Peptidase family M23; Region: Peptidase_M23; pfam01551 935589004094 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 935589004095 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 935589004096 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 935589004097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 935589004098 Transporter associated domain; Region: CorC_HlyC; smart01091 935589004099 succinic semialdehyde dehydrogenase; Region: PLN02278 935589004100 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 935589004101 tetramerization interface [polypeptide binding]; other site 935589004102 NAD(P) binding site [chemical binding]; other site 935589004103 catalytic residues [active] 935589004104 Protein of unknown function (DUF1436); Region: DUF1436; pfam07262 935589004105 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 935589004106 carbon starvation protein A; Provisional; Region: PRK15015 935589004107 Carbon starvation protein CstA; Region: CstA; pfam02554 935589004108 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 935589004109 Uncharacterized small protein [Function unknown]; Region: COG2879 935589004110 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 935589004111 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 935589004112 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589004113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935589004114 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935589004115 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935589004116 Zonular occludens toxin (Zot); Region: Zot; cl17485 935589004117 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935589004118 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935589004119 Replication initiation factor; Region: Rep_trans; pfam02486 935589004120 aspartate kinase; Reviewed; Region: PRK06635 935589004121 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 935589004122 putative nucleotide binding site [chemical binding]; other site 935589004123 putative catalytic residues [active] 935589004124 putative Mg ion binding site [ion binding]; other site 935589004125 putative aspartate binding site [chemical binding]; other site 935589004126 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 935589004127 putative allosteric regulatory site; other site 935589004128 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 935589004129 ribonuclease PH; Reviewed; Region: rph; PRK00173 935589004130 Ribonuclease PH; Region: RNase_PH_bact; cd11362 935589004131 hexamer interface [polypeptide binding]; other site 935589004132 active site 935589004133 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 935589004134 Ligand Binding Site [chemical binding]; other site 935589004135 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 935589004136 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 935589004137 putative ATP binding site [chemical binding]; other site 935589004138 putative substrate interface [chemical binding]; other site 935589004139 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 935589004140 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 935589004141 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 935589004142 active site 935589004143 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 935589004144 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 935589004145 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 935589004146 active site 935589004147 HIGH motif; other site 935589004148 KMSK motif region; other site 935589004149 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 935589004150 tRNA binding surface [nucleotide binding]; other site 935589004151 anticodon binding site; other site 935589004152 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 935589004153 Sulfatase; Region: Sulfatase; cl17466 935589004154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589004155 dimer interface [polypeptide binding]; other site 935589004156 conserved gate region; other site 935589004157 putative PBP binding loops; other site 935589004158 ABC-ATPase subunit interface; other site 935589004159 Staphylococcal nuclease homologues; Region: SNc; smart00318 935589004160 Catalytic site; other site 935589004161 Staphylococcal nuclease homologue; Region: SNase; pfam00565 935589004162 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 935589004163 tetramer (dimer of dimers) interface [polypeptide binding]; other site 935589004164 active site 935589004165 dimer interface [polypeptide binding]; other site 935589004166 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 935589004167 homotrimer interaction site [polypeptide binding]; other site 935589004168 zinc binding site [ion binding]; other site 935589004169 CDP-binding sites; other site 935589004170 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 935589004171 substrate binding site; other site 935589004172 dimer interface; other site 935589004173 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 935589004174 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 935589004175 active site 935589004176 catalytic site [active] 935589004177 substrate binding site [chemical binding]; other site 935589004178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935589004179 Uncharacterized protein, possibly involved in nitrogen fixation [Inorganic ion transport and metabolism]; Region: FixS; COG3197 935589004180 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935589004181 propionate/acetate kinase; Provisional; Region: PRK12379 935589004182 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 935589004183 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 935589004184 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 935589004185 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 935589004186 DsbD alpha interface [polypeptide binding]; other site 935589004187 catalytic residues [active] 935589004188 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 935589004189 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 935589004190 active site lid residues [active] 935589004191 substrate binding pocket [chemical binding]; other site 935589004192 catalytic residues [active] 935589004193 substrate-Mg2+ binding site; other site 935589004194 aspartate-rich region 1; other site 935589004195 aspartate-rich region 2; other site 935589004196 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 935589004197 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935589004198 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 935589004199 FAD binding domain; Region: FAD_binding_4; pfam01565 935589004200 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 935589004201 SmpB-tmRNA interface; other site 935589004202 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 935589004203 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 935589004204 putative active site [active] 935589004205 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 935589004206 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 935589004207 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 935589004208 DNA binding site [nucleotide binding] 935589004209 active site 935589004210 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 935589004211 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 935589004212 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 935589004213 metal binding site [ion binding]; metal-binding site 935589004214 dimer interface [polypeptide binding]; other site 935589004215 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 935589004216 Hemerythrin-like domain; Region: Hr-like; cd12108 935589004217 Fe binding site [ion binding]; other site 935589004218 Azurin [Energy production and conversion]; Region: COG3241 935589004219 Protein of unknown function (DUF721); Region: DUF721; pfam05258 935589004220 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 935589004221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 935589004222 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 935589004223 SEC-C motif; Region: SEC-C; pfam02810 935589004224 DNA primase; Validated; Region: dnaG; PRK05667 935589004225 CHC2 zinc finger; Region: zf-CHC2; pfam01807 935589004226 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 935589004227 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 935589004228 active site 935589004229 metal binding site [ion binding]; metal-binding site 935589004230 interdomain interaction site; other site 935589004231 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 935589004232 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 935589004233 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 935589004234 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 935589004235 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 935589004236 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 935589004237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935589004238 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 935589004239 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935589004240 DNA binding residues [nucleotide binding] 935589004241 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935589004242 Replication initiation factor; Region: Rep_trans; pfam02486 935589004243 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935589004244 Zonular occludens toxin (Zot); Region: Zot; cl17485 935589004245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935589004246 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935589004247 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935589004248 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 935589004249 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589004250 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589004251 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589004252 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935589004253 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935589004254 CTP synthetase; Validated; Region: pyrG; PRK05380 935589004255 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 935589004256 Catalytic site [active] 935589004257 active site 935589004258 UTP binding site [chemical binding]; other site 935589004259 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 935589004260 active site 935589004261 putative oxyanion hole; other site 935589004262 catalytic triad [active] 935589004263 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 935589004264 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 935589004265 acyl-activating enzyme (AAE) consensus motif; other site 935589004266 putative AMP binding site [chemical binding]; other site 935589004267 putative active site [active] 935589004268 putative CoA binding site [chemical binding]; other site 935589004269 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 935589004270 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 935589004271 Ligand Binding Site [chemical binding]; other site 935589004272 Copper(I)-binding protein [Inorganic ion transport and metabolism]; Region: COG2847 935589004273 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 935589004274 glutathione synthetase; Provisional; Region: PRK05246 935589004275 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 935589004276 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 935589004277 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 935589004278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 935589004279 active site 935589004280 HIGH motif; other site 935589004281 nucleotide binding site [chemical binding]; other site 935589004282 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 935589004283 KMSKS motif; other site 935589004284 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 935589004285 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 935589004286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935589004287 putative DNA binding site [nucleotide binding]; other site 935589004288 putative Zn2+ binding site [ion binding]; other site 935589004289 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 935589004290 Predicted membrane protein [Function unknown]; Region: COG2431 935589004291 Transcriptional regulators [Transcription]; Region: GntR; COG1802 935589004292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935589004293 DNA-binding site [nucleotide binding]; DNA binding site 935589004294 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 935589004295 OsmC-like protein; Region: OsmC; cl00767 935589004296 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 935589004297 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 935589004298 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 935589004299 active site 935589004300 substrate binding site [chemical binding]; other site 935589004301 cosubstrate binding site; other site 935589004302 catalytic site [active] 935589004303 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 935589004304 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 935589004305 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 935589004306 DNA polymerase III, chi subunit [DNA replication, recombination, and repair]; Region: HolC; COG2927 935589004307 multifunctional aminopeptidase A; Provisional; Region: PRK00913 935589004308 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 935589004309 interface (dimer of trimers) [polypeptide binding]; other site 935589004310 Substrate-binding/catalytic site; other site 935589004311 Zn-binding sites [ion binding]; other site 935589004312 Predicted permeases [General function prediction only]; Region: COG0795 935589004313 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 935589004314 Predicted permeases [General function prediction only]; Region: COG0795 935589004315 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 935589004316 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 935589004317 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 935589004318 substrate binding site [chemical binding]; other site 935589004319 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 935589004320 substrate binding site [chemical binding]; other site 935589004321 ligand binding site [chemical binding]; other site 935589004322 ornithine carbamoyltransferase; Validated; Region: PRK02102 935589004323 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 935589004324 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 935589004325 ketol-acid reductoisomerase; Provisional; Region: PRK05479 935589004326 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 935589004327 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 935589004328 Uncharacterized conserved protein [Function unknown]; Region: COG1359 935589004329 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 935589004330 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 935589004331 putative valine binding site [chemical binding]; other site 935589004332 dimer interface [polypeptide binding]; other site 935589004333 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 935589004334 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 935589004335 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 935589004336 PYR/PP interface [polypeptide binding]; other site 935589004337 dimer interface [polypeptide binding]; other site 935589004338 TPP binding site [chemical binding]; other site 935589004339 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 935589004340 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 935589004341 TPP-binding site [chemical binding]; other site 935589004342 dimer interface [polypeptide binding]; other site 935589004343 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 935589004344 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 935589004345 Cu(I) binding site [ion binding]; other site 935589004346 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 935589004347 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 935589004348 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 935589004349 GIY-YIG motif/motif A; other site 935589004350 putative active site [active] 935589004351 putative metal binding site [ion binding]; other site 935589004352 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 935589004353 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 935589004354 NAD binding site [chemical binding]; other site 935589004355 dimerization interface [polypeptide binding]; other site 935589004356 product binding site; other site 935589004357 substrate binding site [chemical binding]; other site 935589004358 zinc binding site [ion binding]; other site 935589004359 catalytic residues [active] 935589004360 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 935589004361 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935589004362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004363 homodimer interface [polypeptide binding]; other site 935589004364 catalytic residue [active] 935589004365 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 935589004366 putative active site pocket [active] 935589004367 4-fold oligomerization interface [polypeptide binding]; other site 935589004368 metal binding residues [ion binding]; metal-binding site 935589004369 3-fold/trimer interface [polypeptide binding]; other site 935589004370 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 935589004371 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 935589004372 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 935589004373 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 935589004374 putative inner membrane peptidase; Provisional; Region: PRK11778 935589004375 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 935589004376 tandem repeat interface [polypeptide binding]; other site 935589004377 oligomer interface [polypeptide binding]; other site 935589004378 active site residues [active] 935589004379 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 935589004380 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 935589004381 Cupin; Region: Cupin_6; pfam12852 935589004382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 935589004383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 935589004384 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 935589004385 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 935589004386 EamA-like transporter family; Region: EamA; pfam00892 935589004387 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 935589004388 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935589004389 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 935589004390 motif 1; other site 935589004391 active site 935589004392 motif 2; other site 935589004393 motif 3; other site 935589004394 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 935589004395 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 935589004396 DHHA1 domain; Region: DHHA1; pfam02272 935589004397 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 935589004398 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 935589004399 cofactor binding site; other site 935589004400 DNA binding site [nucleotide binding] 935589004401 substrate interaction site [chemical binding]; other site 935589004402 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 935589004403 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 935589004404 gating phenylalanine in ion channel; other site 935589004405 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935589004406 catalytic core [active] 935589004407 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 935589004408 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 935589004409 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 935589004410 CAP-like domain; other site 935589004411 active site 935589004412 primary dimer interface [polypeptide binding]; other site 935589004413 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 935589004414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935589004415 active site 935589004416 phosphorylation site [posttranslational modification] 935589004417 intermolecular recognition site; other site 935589004418 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 935589004419 Putative SAM-dependent methyltransferase; Region: SAM_MT; pfam04445 935589004420 Protein of unknown function (DUF2788); Region: DUF2788; pfam10981 935589004421 O-succinylhomoserine sulfhydrylase; Region: O_suc_HS_sulf; TIGR01325 935589004422 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 935589004423 homodimer interface [polypeptide binding]; other site 935589004424 substrate-cofactor binding pocket; other site 935589004425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004426 catalytic residue [active] 935589004427 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 935589004428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 935589004429 substrate binding pocket [chemical binding]; other site 935589004430 membrane-bound complex binding site; other site 935589004431 hinge residues; other site 935589004432 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 935589004433 Fumarase C-terminus; Region: Fumerase_C; pfam05683 935589004434 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 935589004435 TrkA-N domain; Region: TrkA_N; pfam02254 935589004436 TrkA-C domain; Region: TrkA_C; pfam02080 935589004437 TrkA-N domain; Region: TrkA_N; pfam02254 935589004438 TrkA-C domain; Region: TrkA_C; pfam02080 935589004439 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 935589004440 dimer interface [polypeptide binding]; other site 935589004441 substrate binding site [chemical binding]; other site 935589004442 ATP binding site [chemical binding]; other site 935589004443 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 935589004444 tellurite resistance protein TehB; Provisional; Region: PRK12335 935589004445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935589004446 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 935589004447 RNA/DNA hybrid binding site [nucleotide binding]; other site 935589004448 active site 935589004449 HIT domain; Region: HIT; pfam01230 935589004450 HIT family signature motif; other site 935589004451 catalytic residue [active] 935589004452 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 935589004453 dimer interface [polypeptide binding]; other site 935589004454 catalytic triad [active] 935589004455 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 935589004456 catalytic residues [active] 935589004457 dimer interface [polypeptide binding]; other site 935589004458 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 935589004459 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 935589004460 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 935589004461 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 935589004462 Multicopper oxidase; Region: Cu-oxidase; pfam00394 935589004463 Uncharacterized conserved protein [Function unknown]; Region: COG1262 935589004464 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 935589004465 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935589004466 Replication initiation factor; Region: Rep_trans; pfam02486 935589004467 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935589004468 Zonular occludens toxin (Zot); Region: Zot; cl17485 935589004469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935589004470 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935589004471 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935589004472 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935589004473 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 935589004474 putative FMN binding site [chemical binding]; other site 935589004475 putative metal dependent hydrolase; Provisional; Region: PRK11598 935589004476 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 935589004477 Sulfatase; Region: Sulfatase; pfam00884 935589004478 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 935589004479 homodimer interface [polypeptide binding]; other site 935589004480 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 935589004481 substrate-cofactor binding pocket; other site 935589004482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004483 catalytic residue [active] 935589004484 ribosome maturation protein RimP; Reviewed; Region: PRK00092 935589004485 Sm and related proteins; Region: Sm_like; cl00259 935589004486 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 935589004487 putative oligomer interface [polypeptide binding]; other site 935589004488 putative RNA binding site [nucleotide binding]; other site 935589004489 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 935589004490 NusA N-terminal domain; Region: NusA_N; pfam08529 935589004491 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 935589004492 RNA binding site [nucleotide binding]; other site 935589004493 homodimer interface [polypeptide binding]; other site 935589004494 NusA-like KH domain; Region: KH_5; pfam13184 935589004495 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 935589004496 G-X-X-G motif; other site 935589004497 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 935589004498 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 935589004499 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935589004500 translation initiation factor IF-2; Region: IF-2; TIGR00487 935589004501 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 935589004502 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 935589004503 G1 box; other site 935589004504 putative GEF interaction site [polypeptide binding]; other site 935589004505 GTP/Mg2+ binding site [chemical binding]; other site 935589004506 Switch I region; other site 935589004507 G2 box; other site 935589004508 G3 box; other site 935589004509 Switch II region; other site 935589004510 G4 box; other site 935589004511 G5 box; other site 935589004512 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 935589004513 Translation-initiation factor 2; Region: IF-2; pfam11987 935589004514 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 935589004515 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 935589004516 G1 box; other site 935589004517 GTP/Mg2+ binding site [chemical binding]; other site 935589004518 G2 box; other site 935589004519 Switch I region; other site 935589004520 G3 box; other site 935589004521 Switch II region; other site 935589004522 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 935589004523 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 935589004524 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 935589004525 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 935589004526 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 935589004527 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 935589004528 hypothetical protein; Validated; Region: PRK00110 935589004529 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 935589004530 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 935589004531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 935589004532 putative DNA binding site [nucleotide binding]; other site 935589004533 putative Zn2+ binding site [ion binding]; other site 935589004534 AsnC family; Region: AsnC_trans_reg; pfam01037 935589004535 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 935589004536 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 935589004537 active site 935589004538 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935589004539 substrate binding site [chemical binding]; other site 935589004540 catalytic residues [active] 935589004541 dimer interface [polypeptide binding]; other site 935589004542 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 935589004543 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 935589004544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 935589004545 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 935589004546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589004547 S-adenosylmethionine binding site [chemical binding]; other site 935589004548 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 935589004549 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 935589004550 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 935589004551 Flavoprotein; Region: Flavoprotein; pfam02441 935589004552 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 935589004553 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935589004554 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 935589004555 Zn2+ binding site [ion binding]; other site 935589004556 Mg2+ binding site [ion binding]; other site 935589004557 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935589004558 synthetase active site [active] 935589004559 NTP binding site [chemical binding]; other site 935589004560 metal binding site [ion binding]; metal-binding site 935589004561 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935589004562 ACT domain; Region: ACT_4; pfam13291 935589004563 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 935589004564 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 935589004565 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 935589004566 catalytic site [active] 935589004567 G-X2-G-X-G-K; other site 935589004568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589004569 active site 935589004570 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 935589004571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589004572 active site 935589004573 motif I; other site 935589004574 motif II; other site 935589004575 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589004576 putative protease; Provisional; Region: PRK15452 935589004577 Peptidase family U32; Region: Peptidase_U32; pfam01136 935589004578 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 935589004579 putative active site [active] 935589004580 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 935589004581 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 935589004582 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935589004583 N-terminal plug; other site 935589004584 ligand-binding site [chemical binding]; other site 935589004585 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 935589004586 heme binding pocket [chemical binding]; other site 935589004587 heme ligand [chemical binding]; other site 935589004588 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 935589004589 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 935589004590 Paraquat-inducible protein A; Region: PqiA; pfam04403 935589004591 Paraquat-inducible protein A; Region: PqiA; pfam04403 935589004592 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 935589004593 mce related protein; Region: MCE; pfam02470 935589004594 mce related protein; Region: MCE; pfam02470 935589004595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 935589004596 Protein of unknown function (DUF330); Region: DUF330; pfam03886 935589004597 3-methyladenine DNA glycosylase [DNA replication, recombination, and repair]; Region: Tag; COG2818 935589004598 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 935589004599 active site 935589004600 catalytic triad [active] 935589004601 oxyanion hole [active] 935589004602 switch loop; other site 935589004603 glycine dehydrogenase; Provisional; Region: PRK05367 935589004604 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935589004605 tetramer interface [polypeptide binding]; other site 935589004606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004607 catalytic residue [active] 935589004608 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 935589004609 tetramer interface [polypeptide binding]; other site 935589004610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004611 catalytic residue [active] 935589004612 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 935589004613 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 935589004614 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 935589004615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 935589004616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004617 homodimer interface [polypeptide binding]; other site 935589004618 catalytic residue [active] 935589004619 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 935589004620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589004621 S-adenosylmethionine binding site [chemical binding]; other site 935589004622 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 935589004623 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 935589004624 Tetramer interface [polypeptide binding]; other site 935589004625 active site 935589004626 FMN-binding site [chemical binding]; other site 935589004627 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 935589004628 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 935589004629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 935589004630 ATP binding site [chemical binding]; other site 935589004631 Mg2+ binding site [ion binding]; other site 935589004632 G-X-G motif; other site 935589004633 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 935589004634 anchoring element; other site 935589004635 dimer interface [polypeptide binding]; other site 935589004636 ATP binding site [chemical binding]; other site 935589004637 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 935589004638 active site 935589004639 metal binding site [ion binding]; metal-binding site 935589004640 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 935589004641 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 935589004642 putative active site [active] 935589004643 Ap4A binding site [chemical binding]; other site 935589004644 nudix motif; other site 935589004645 putative metal binding site [ion binding]; other site 935589004646 seryl-tRNA synthetase; Provisional; Region: PRK05431 935589004647 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 935589004648 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 935589004649 dimer interface [polypeptide binding]; other site 935589004650 active site 935589004651 motif 1; other site 935589004652 motif 2; other site 935589004653 motif 3; other site 935589004654 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 935589004655 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 935589004656 putative ligand binding site [chemical binding]; other site 935589004657 putative NAD binding site [chemical binding]; other site 935589004658 catalytic site [active] 935589004659 peptide chain release factor 1; Validated; Region: prfA; PRK00591 935589004660 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935589004661 RF-1 domain; Region: RF-1; pfam00472 935589004662 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 935589004663 active site 935589004664 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 935589004665 active site 935589004666 homodimer interface [polypeptide binding]; other site 935589004667 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 935589004668 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 935589004669 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 935589004670 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 935589004671 active site 935589004672 substrate binding site [chemical binding]; other site 935589004673 metal binding site [ion binding]; metal-binding site 935589004674 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 935589004675 dihydropteroate synthase; Region: DHPS; TIGR01496 935589004676 substrate binding pocket [chemical binding]; other site 935589004677 dimer interface [polypeptide binding]; other site 935589004678 inhibitor binding site; inhibition site 935589004679 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 935589004680 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 935589004681 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 935589004682 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 935589004683 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4899 935589004684 Predicted membrane protein [Function unknown]; Region: COG4648 935589004685 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 935589004686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589004687 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 935589004688 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 935589004689 dimer interface [polypeptide binding]; other site 935589004690 active site 935589004691 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 935589004692 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 935589004693 putative metal binding site; other site 935589004694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 935589004695 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 935589004696 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 935589004697 Na2 binding site [ion binding]; other site 935589004698 putative substrate binding site 1 [chemical binding]; other site 935589004699 Na binding site 1 [ion binding]; other site 935589004700 putative substrate binding site 2 [chemical binding]; other site 935589004701 ApbE family; Region: ApbE; pfam02424 935589004702 thymidylate synthase; Reviewed; Region: thyA; PRK01827 935589004703 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 935589004704 dimerization interface [polypeptide binding]; other site 935589004705 active site 935589004706 glutamate dehydrogenase; Provisional; Region: PRK09414 935589004707 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 935589004708 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 935589004709 NAD(P) binding site [chemical binding]; other site 935589004710 Transcriptional regulators [Transcription]; Region: FadR; COG2186 935589004711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 935589004712 DNA-binding site [nucleotide binding]; DNA binding site 935589004713 FCD domain; Region: FCD; pfam07729 935589004714 L-lactate permease; Region: Lactate_perm; cl00701 935589004715 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 935589004716 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 935589004717 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 935589004718 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935589004719 HlyD family secretion protein; Region: HlyD_3; pfam13437 935589004720 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 935589004721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 935589004722 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 935589004723 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 935589004724 AbgT putative transporter family; Region: ABG_transport; pfam03806 935589004725 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 935589004726 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 935589004727 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 935589004728 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 935589004729 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 935589004730 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 935589004731 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 935589004732 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 935589004733 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 935589004734 Low-spin heme binding site [chemical binding]; other site 935589004735 Putative water exit pathway; other site 935589004736 Binuclear center (active site) [active] 935589004737 Putative proton exit pathway; other site 935589004738 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 935589004739 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 935589004740 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 935589004741 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 935589004742 protein binding site [polypeptide binding]; other site 935589004743 TIGR01244 family protein; Region: TIGR01244 935589004744 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 935589004745 TolR protein; Region: tolR; TIGR02801 935589004746 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 935589004747 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 935589004748 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 935589004749 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 935589004750 Peptidase family M50; Region: Peptidase_M50; pfam02163 935589004751 active site 935589004752 putative substrate binding region [chemical binding]; other site 935589004753 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 935589004754 Glutaredoxin 2 [Posttranslational modification, protein turnover, chaperones]; Region: GrxB; COG2999 935589004755 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 935589004756 C-terminal domain interface [polypeptide binding]; other site 935589004757 GSH binding site (G-site) [chemical binding]; other site 935589004758 catalytic residues [active] 935589004759 putative dimer interface [polypeptide binding]; other site 935589004760 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 935589004761 N-terminal domain interface [polypeptide binding]; other site 935589004762 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 935589004763 HD domain; Region: HD_4; pfam13328 935589004764 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 935589004765 synthetase active site [active] 935589004766 NTP binding site [chemical binding]; other site 935589004767 metal binding site [ion binding]; metal-binding site 935589004768 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 935589004769 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 935589004770 DDE superfamily endonuclease; Region: DDE_3; pfam13358 935589004771 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 935589004772 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 935589004773 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 935589004774 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 935589004775 HlyD family secretion protein; Region: HlyD_3; pfam13437 935589004776 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 935589004777 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935589004778 Replication initiation factor; Region: Rep_trans; pfam02486 935589004779 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935589004780 Protein of unknown function (DUF2523); Region: DUF2523; pfam10734 935589004781 Zonular occludens toxin (Zot); Region: Zot; pfam05707 935589004782 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 935589004783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 935589004784 Transposase; Region: DEDD_Tnp_IS110; pfam01548 935589004785 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 935589004786 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004787 Integrase core domain; Region: rve; pfam00665 935589004788 Integrase core domain; Region: rve_2; pfam13333 935589004789 Helix-turn-helix domain; Region: HTH_28; pfam13518 935589004790 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 935589004791 Fic family protein [Function unknown]; Region: COG3177 935589004792 Fic/DOC family; Region: Fic; pfam02661 935589004793 oxidoreductase; Region: PLN02991 935589004794 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 935589004795 HipA N-terminal domain; Region: Couple_hipA; pfam13657 935589004796 HipA-like N-terminal domain; Region: HipA_N; pfam07805 935589004797 HipA-like C-terminal domain; Region: HipA_C; pfam07804 935589004798 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935589004799 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935589004800 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935589004801 ACP:hemolysin acyltransferase (hemolysin-activating protein) [Posttranslational modification, protein turnover, chaperones]; Region: HlyC; COG2994 935589004802 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004803 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004804 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004805 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 935589004806 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935589004807 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004808 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004809 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004810 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004811 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589004812 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589004813 Homeodomain-like domain; Region: HTH_32; pfam13565 935589004814 Integrase core domain; Region: rve; pfam00665 935589004815 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589004816 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004817 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589004818 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004819 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589004820 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004821 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 935589004822 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004823 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589004824 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 935589004825 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935589004826 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004827 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 935589004828 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 935589004829 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 935589004830 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 935589004831 Protein involved in initiation of plasmid replication [DNA replication, recombination, and repair]; Region: COG5527 935589004832 Initiator Replication protein; Region: Rep_3; pfam01051 935589004833 haemagglutination activity domain; Region: Haemagg_act; pfam05860 935589004834 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 935589004835 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004836 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004837 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004838 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 935589004839 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 935589004840 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 935589004841 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 935589004842 Helix-turn-helix domain; Region: HTH_38; pfam13936 935589004843 Homeodomain-like domain; Region: HTH_32; pfam13565 935589004844 Integrase core domain; Region: rve; pfam00665 935589004845 Putative phage replication protein RstA [DNA replication, recombination, and repair]; Region: COG2946 935589004846 Replication initiation factor; Region: Rep_trans; pfam02486 935589004847 Protein of unknown function (DUF1132); Region: DUF1132; pfam06575 935589004848 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 935589004849 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 935589004850 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 935589004851 G1 box; other site 935589004852 GTP/Mg2+ binding site [chemical binding]; other site 935589004853 G2 box; other site 935589004854 Switch I region; other site 935589004855 G3 box; other site 935589004856 Switch II region; other site 935589004857 G4 box; other site 935589004858 G5 box; other site 935589004859 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 935589004860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 935589004861 active site 935589004862 phosphorylation site [posttranslational modification] 935589004863 intermolecular recognition site; other site 935589004864 dimerization interface [polypeptide binding]; other site 935589004865 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 935589004866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589004867 S-adenosylmethionine binding site [chemical binding]; other site 935589004868 Protein of unknown function (DUF452); Region: DUF452; cl01062 935589004869 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 935589004870 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 935589004871 substrate-cofactor binding pocket; other site 935589004872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 935589004873 catalytic residue [active] 935589004874 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 935589004875 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 935589004876 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 935589004877 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 935589004878 transmembrane helices; other site 935589004879 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 935589004880 agmatinase; Region: agmatinase; TIGR01230 935589004881 oligomer interface [polypeptide binding]; other site 935589004882 putative active site [active] 935589004883 Mn binding site [ion binding]; other site 935589004884 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 935589004885 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 935589004886 dimer interface [polypeptide binding]; other site 935589004887 active site 935589004888 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 935589004889 catalytic residues [active] 935589004890 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 935589004891 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 935589004892 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 935589004893 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 935589004894 dimer interface [polypeptide binding]; other site 935589004895 anticodon binding site; other site 935589004896 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935589004897 homodimer interface [polypeptide binding]; other site 935589004898 motif 1; other site 935589004899 active site 935589004900 motif 2; other site 935589004901 GAD domain; Region: GAD; pfam02938 935589004902 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 935589004903 motif 3; other site 935589004904 Uncharacterized conserved protein [Function unknown]; Region: COG2928 935589004905 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 935589004906 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 935589004907 dimerization interface [polypeptide binding]; other site 935589004908 substrate binding site [chemical binding]; other site 935589004909 active site 935589004910 calcium binding site [ion binding]; other site 935589004911 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 935589004912 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 935589004913 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 935589004914 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 935589004915 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 935589004916 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 935589004917 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935589004918 glutamate racemase; Provisional; Region: PRK00865 935589004919 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 935589004920 AMIN domain; Region: AMIN; pfam11741 935589004921 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 935589004922 active site 935589004923 metal binding site [ion binding]; metal-binding site 935589004924 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 935589004925 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 935589004926 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 935589004927 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 935589004928 active site 935589004929 8-oxo-dGMP binding site [chemical binding]; other site 935589004930 nudix motif; other site 935589004931 metal binding site [ion binding]; metal-binding site 935589004932 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 935589004933 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 935589004934 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 935589004935 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 935589004936 active site 935589004937 hydrophilic channel; other site 935589004938 dimerization interface [polypeptide binding]; other site 935589004939 catalytic residues [active] 935589004940 active site lid [active] 935589004941 Recombination protein O N terminal; Region: RecO_N; pfam11967 935589004942 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 935589004943 Recombination protein O C terminal; Region: RecO_C; pfam02565 935589004944 chorismate mutase domain of proteobacterial P-protein, clade 2; Region: CM_P2; TIGR01807 935589004945 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 935589004946 Prephenate dehydratase; Region: PDT; pfam00800 935589004947 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 935589004948 putative L-Phe binding site [chemical binding]; other site 935589004949 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 935589004950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589004951 putative substrate translocation pore; other site 935589004952 EamA-like transporter family; Region: EamA; pfam00892 935589004953 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 935589004954 EamA-like transporter family; Region: EamA; pfam00892 935589004955 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 935589004956 Predicted amidohydrolase [General function prediction only]; Region: COG0388 935589004957 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 935589004958 putative active site [active] 935589004959 catalytic triad [active] 935589004960 dimer interface [polypeptide binding]; other site 935589004961 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 935589004962 prephenate dehydrogenase; Validated; Region: PRK08507 935589004963 Uncharacterized protein involved in response to NO [Inorganic ion transport and metabolism]; Region: NnrS; COG3213 935589004964 Transcriptional regulator; Region: Rrf2; cl17282 935589004965 Rrf2 family protein; Region: rrf2_super; TIGR00738 935589004966 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 935589004967 propionate/acetate kinase; Provisional; Region: PRK12379 935589004968 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 935589004969 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 935589004970 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 935589004971 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 935589004972 substrate binding site [chemical binding]; other site 935589004973 ligand binding site [chemical binding]; other site 935589004974 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 935589004975 substrate binding site [chemical binding]; other site 935589004976 Protein of unknown function (DUF819); Region: DUF819; cl02317 935589004977 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 935589004978 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 935589004979 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 935589004980 dimer interface [polypeptide binding]; other site 935589004981 active site 935589004982 citrylCoA binding site [chemical binding]; other site 935589004983 oxalacetate/citrate binding site [chemical binding]; other site 935589004984 coenzyme A binding site [chemical binding]; other site 935589004985 catalytic triad [active] 935589004986 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 935589004987 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 935589004988 tetramer interface [polypeptide binding]; other site 935589004989 active site 935589004990 Mg2+/Mn2+ binding site [ion binding]; other site 935589004991 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 935589004992 cell division protein FtsZ; Validated; Region: PRK09330 935589004993 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 935589004994 nucleotide binding site [chemical binding]; other site 935589004995 SulA interaction site; other site 935589004996 cell division protein FtsA; Region: ftsA; TIGR01174 935589004997 Cell division protein FtsA; Region: FtsA; smart00842 935589004998 Cell division protein FtsA; Region: FtsA; pfam14450 935589004999 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 935589005000 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 935589005001 Cell division protein FtsQ; Region: FtsQ; pfam03799 935589005002 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 935589005003 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 935589005004 ATP-grasp domain; Region: ATP-grasp_4; cl17255 935589005005 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 935589005006 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935589005007 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935589005008 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935589005009 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 935589005010 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 935589005011 active site 935589005012 homodimer interface [polypeptide binding]; other site 935589005013 cell division protein FtsW; Region: ftsW; TIGR02614 935589005014 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04308 935589005015 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935589005016 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935589005017 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 935589005018 Sel1-like repeats; Region: SEL1; smart00671 935589005019 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 935589005020 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 935589005021 Mg++ binding site [ion binding]; other site 935589005022 putative catalytic motif [active] 935589005023 putative substrate binding site [chemical binding]; other site 935589005024 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 935589005025 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935589005026 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 935589005027 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935589005028 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935589005029 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 935589005030 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 935589005031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 935589005032 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 935589005033 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 935589005034 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 935589005035 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 935589005036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 935589005037 MraW methylase family; Region: Methyltransf_5; cl17771 935589005038 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 935589005039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 935589005040 MraZ protein; Region: MraZ; pfam02381 935589005041 MraZ protein; Region: MraZ; pfam02381 935589005042 Uncharacterized conserved protein [Function unknown]; Region: COG1565 935589005043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 935589005044 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 935589005045 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 935589005046 catalytic residues [active] 935589005047 hinge region; other site 935589005048 alpha helical domain; other site 935589005049 cell division protein FtsN; Region: ftsN; TIGR02223 935589005050 Sporulation related domain; Region: SPOR; pfam05036 935589005051 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 935589005052 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 935589005053 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 935589005054 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 935589005055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 935589005056 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 935589005057 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 935589005058 Na binding site [ion binding]; other site 935589005059 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 935589005060 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 935589005061 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 935589005062 Glutamate binding site [chemical binding]; other site 935589005063 NAD binding site [chemical binding]; other site 935589005064 catalytic residues [active] 935589005065 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 935589005066 putative catalytic site [active] 935589005067 putative phosphate binding site [ion binding]; other site 935589005068 active site 935589005069 metal binding site A [ion binding]; metal-binding site 935589005070 DNA binding site [nucleotide binding] 935589005071 putative AP binding site [nucleotide binding]; other site 935589005072 putative metal binding site B [ion binding]; other site 935589005073 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 935589005074 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 935589005075 dimerization interface [polypeptide binding]; other site 935589005076 active site 935589005077 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 935589005078 quinolinate synthetase; Provisional; Region: PRK09375 935589005079 L-aspartate oxidase; Provisional; Region: PRK06175 935589005080 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 935589005081 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 935589005082 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589005083 motif II; other site 935589005084 maltose phosphorylase; Provisional; Region: PRK13807 935589005085 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 935589005086 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 935589005087 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 935589005088 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 935589005089 active site 935589005090 catalytic residues [active] 935589005091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589005092 putative substrate translocation pore; other site 935589005093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 935589005094 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 935589005095 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589005096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589005097 ABC transporter; Region: ABC_tran_2; pfam12848 935589005098 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 935589005099 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 935589005100 tetramer interfaces [polypeptide binding]; other site 935589005101 binuclear metal-binding site [ion binding]; other site 935589005102 thiamine-monophosphate kinase; Region: thiL; TIGR01379 935589005103 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 935589005104 ATP binding site [chemical binding]; other site 935589005105 dimerization interface [polypeptide binding]; other site 935589005106 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 935589005107 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 935589005108 ligand binding site [chemical binding]; other site 935589005109 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 935589005110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935589005111 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 935589005112 substrate binding site [chemical binding]; other site 935589005113 dimerization interface [polypeptide binding]; other site 935589005114 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 935589005115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 935589005116 FeS/SAM binding site; other site 935589005117 HemN C-terminal domain; Region: HemN_C; pfam06969 935589005118 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 935589005119 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 935589005120 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 935589005121 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935589005122 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935589005123 protein-splicing catalytic site; other site 935589005124 thioester formation/cholesterol transfer; other site 935589005125 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935589005126 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 935589005127 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 935589005128 Pretoxin HINT domain; Region: PT-HINT; pfam07591 935589005129 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 935589005130 thioester formation/cholesterol transfer; other site 935589005131 protein-splicing catalytic site; other site 935589005132 RTX iron-regulated protein FrpC; Region: FrpC; pfam06901 935589005133 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 935589005134 GIY-YIG motif/motif A; other site 935589005135 putative active site [active] 935589005136 putative metal binding site [ion binding]; other site 935589005137 muropeptide transporter; Reviewed; Region: ampG; PRK11902 935589005138 AmpG-like permease; Region: 2A0125; TIGR00901 935589005139 glutamine synthetase; Provisional; Region: glnA; PRK09469 935589005140 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 935589005141 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 935589005142 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 935589005143 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 935589005144 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 935589005145 shikimate binding site; other site 935589005146 NAD(P) binding site [chemical binding]; other site 935589005147 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 935589005148 Transglycosylase; Region: Transgly; cl17702 935589005149 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 935589005150 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 935589005151 Walker A/P-loop; other site 935589005152 ATP binding site [chemical binding]; other site 935589005153 Q-loop/lid; other site 935589005154 ABC transporter signature motif; other site 935589005155 Walker B; other site 935589005156 D-loop; other site 935589005157 H-loop/switch region; other site 935589005158 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 935589005159 OstA-like protein; Region: OstA; pfam03968 935589005160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 935589005161 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 935589005162 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 935589005163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589005164 active site 935589005165 motif I; other site 935589005166 motif II; other site 935589005167 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 935589005168 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 935589005169 putative active site [active] 935589005170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 935589005171 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 935589005172 putative active site [active] 935589005173 transaldolase; Provisional; Region: PRK03903 935589005174 catalytic residue [active] 935589005175 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 935589005176 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 935589005177 active site 935589005178 HIGH motif; other site 935589005179 nucleotide binding site [chemical binding]; other site 935589005180 active site 935589005181 KMSKS motif; other site 935589005182 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 935589005183 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 935589005184 FMN binding site [chemical binding]; other site 935589005185 active site 935589005186 catalytic residues [active] 935589005187 substrate binding site [chemical binding]; other site 935589005188 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 935589005189 putative active site [active] 935589005190 dimerization interface [polypeptide binding]; other site 935589005191 putative tRNAtyr binding site [nucleotide binding]; other site 935589005192 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 935589005193 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935589005194 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 935589005195 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 935589005196 YciI-like protein; Reviewed; Region: PRK11370 935589005197 intracellular septation protein A; Reviewed; Region: PRK00259 935589005198 Tfp pilus assembly protein FimV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimV; COG3170 935589005199 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 935589005200 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 935589005201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 935589005202 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 935589005203 dimer interface [polypeptide binding]; other site 935589005204 active site 935589005205 metal binding site [ion binding]; metal-binding site 935589005206 glutathione binding site [chemical binding]; other site 935589005207 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 935589005208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935589005209 TPR motif; other site 935589005210 binding surface 935589005211 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 935589005212 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 935589005213 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 935589005214 homodimer interface [polypeptide binding]; other site 935589005215 substrate-cofactor binding pocket; other site 935589005216 catalytic residue [active] 935589005217 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08690 935589005218 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 935589005219 NAD binding site [chemical binding]; other site 935589005220 homotetramer interface [polypeptide binding]; other site 935589005221 homodimer interface [polypeptide binding]; other site 935589005222 substrate binding site [chemical binding]; other site 935589005223 active site 935589005224 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 935589005225 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 935589005226 trimer interface [polypeptide binding]; other site 935589005227 active site 935589005228 substrate binding site [chemical binding]; other site 935589005229 CoA binding site [chemical binding]; other site 935589005230 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 935589005231 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 935589005232 active site 935589005233 dimer interface [polypeptide binding]; other site 935589005234 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 935589005235 dimer interface [polypeptide binding]; other site 935589005236 active site 935589005237 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 935589005238 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 935589005239 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 935589005240 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 935589005241 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 935589005242 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 935589005243 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 935589005244 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 935589005245 CoA-binding site [chemical binding]; other site 935589005246 ATP-binding [chemical binding]; other site 935589005247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3024 935589005248 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 935589005249 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 935589005250 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 935589005251 Walker A motif; other site 935589005252 ATP binding site [chemical binding]; other site 935589005253 Walker B motif; other site 935589005254 Predicted membrane protein [Function unknown]; Region: COG2707 935589005255 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 935589005256 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 935589005257 substrate binding pocket [chemical binding]; other site 935589005258 chain length determination region; other site 935589005259 substrate-Mg2+ binding site; other site 935589005260 catalytic residues [active] 935589005261 aspartate-rich region 1; other site 935589005262 active site lid residues [active] 935589005263 aspartate-rich region 2; other site 935589005264 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 935589005265 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 935589005266 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 935589005267 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 935589005268 hypothetical protein; Provisional; Region: PRK09126 935589005269 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 935589005270 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 935589005271 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 935589005272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 935589005273 putative substrate translocation pore; other site 935589005274 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 935589005275 HlyD family secretion protein; Region: HlyD_3; pfam13437 935589005276 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 935589005277 hypothetical protein; Provisional; Region: PRK11212 935589005278 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 935589005279 Peptidase family M23; Region: Peptidase_M23; pfam01551 935589005280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 935589005281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 935589005282 binding surface 935589005283 Tetratricopeptide repeat; Region: TPR_16; pfam13432 935589005284 TPR motif; other site 935589005285 Protein of unknown function (DUF560); Region: DUF560; pfam04575 935589005286 Predicted membrane protein [Function unknown]; Region: COG1981 935589005287 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 935589005288 putative active site [active] 935589005289 putative metal binding residues [ion binding]; other site 935589005290 signature motif; other site 935589005291 putative dimer interface [polypeptide binding]; other site 935589005292 putative phosphate binding site [ion binding]; other site 935589005293 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 935589005294 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 935589005295 folate binding site [chemical binding]; other site 935589005296 NADP+ binding site [chemical binding]; other site 935589005297 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 935589005298 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 935589005299 DDE superfamily endonuclease; Region: DDE_3; pfam13358 935589005300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589005301 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 935589005302 Helix-hairpin-helix motif; Region: HHH; pfam00633 935589005303 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 935589005304 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 935589005305 active site 935589005306 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 935589005307 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 935589005308 active site 935589005309 (T/H)XGH motif; other site 935589005310 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 935589005311 YccA-like proteins; Region: YccA_like; cd10433 935589005312 oxidative damage protection protein; Provisional; Region: PRK05408 935589005313 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 935589005314 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 935589005315 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 935589005316 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 935589005317 active site 935589005318 (T/H)XGH motif; other site 935589005319 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 935589005320 active site clefts [active] 935589005321 zinc binding site [ion binding]; other site 935589005322 dimer interface [polypeptide binding]; other site 935589005323 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 935589005324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589005325 dimer interface [polypeptide binding]; other site 935589005326 conserved gate region; other site 935589005327 ABC-ATPase subunit interface; other site 935589005328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 935589005329 dimer interface [polypeptide binding]; other site 935589005330 ABC-ATPase subunit interface; other site 935589005331 putative PBP binding loops; other site 935589005332 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 935589005333 fructuronate transporter; Provisional; Region: PRK10034; cl15264 935589005334 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 935589005335 ATP-binding site [chemical binding]; other site 935589005336 Gluconate-6-phosphate binding site [chemical binding]; other site 935589005337 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 935589005338 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 935589005339 putative active site [active] 935589005340 putative substrate binding site [chemical binding]; other site 935589005341 ATP binding site [chemical binding]; other site 935589005342 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 935589005343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589005344 S-adenosylmethionine binding site [chemical binding]; other site 935589005345 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 935589005346 aromatic amino acid transport protein; Region: araaP; TIGR00837 935589005347 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 935589005348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 935589005349 active site 935589005350 motif I; other site 935589005351 motif II; other site 935589005352 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 935589005353 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 935589005354 putative acyl-acceptor binding pocket; other site 935589005355 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 935589005356 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 935589005357 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 935589005358 dimerization interface 3.5A [polypeptide binding]; other site 935589005359 active site 935589005360 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 935589005361 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 935589005362 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 935589005363 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 935589005364 trimer interface [polypeptide binding]; other site 935589005365 eyelet of channel; other site 935589005366 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 935589005367 ThiC-associated domain; Region: ThiC-associated; pfam13667 935589005368 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 935589005369 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 935589005370 nudix motif; other site 935589005371 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 935589005372 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 935589005373 Walker A/P-loop; other site 935589005374 ATP binding site [chemical binding]; other site 935589005375 Q-loop/lid; other site 935589005376 ABC transporter signature motif; other site 935589005377 Walker B; other site 935589005378 D-loop; other site 935589005379 H-loop/switch region; other site 935589005380 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 935589005381 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 935589005382 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 935589005383 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 935589005384 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 935589005385 dimerization domain swap beta strand [polypeptide binding]; other site 935589005386 regulatory protein interface [polypeptide binding]; other site 935589005387 active site 935589005388 regulatory phosphorylation site [posttranslational modification]; other site 935589005389 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 935589005390 active pocket/dimerization site; other site 935589005391 active site 935589005392 phosphorylation site [posttranslational modification] 935589005393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 935589005394 active site 935589005395 DNA ligase; Provisional; Region: PRK09125 935589005396 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 935589005397 DNA binding site [nucleotide binding] 935589005398 active site 935589005399 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 935589005400 DNA binding site [nucleotide binding] 935589005401 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 935589005402 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 935589005403 RmuC family; Region: RmuC; pfam02646 935589005404 Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857 935589005405 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 935589005406 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 935589005407 Qi binding site; other site 935589005408 intrachain domain interface; other site 935589005409 interchain domain interface [polypeptide binding]; other site 935589005410 heme bH binding site [chemical binding]; other site 935589005411 heme bL binding site [chemical binding]; other site 935589005412 Qo binding site; other site 935589005413 interchain domain interface [polypeptide binding]; other site 935589005414 intrachain domain interface; other site 935589005415 Qi binding site; other site 935589005416 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 935589005417 Qo binding site; other site 935589005418 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 935589005419 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 935589005420 [2Fe-2S] cluster binding site [ion binding]; other site 935589005421 Uncharacterized conserved protein [Function unknown]; Region: COG0327 935589005422 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 935589005423 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 935589005424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 935589005425 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 935589005426 putative dimerization interface [polypeptide binding]; other site 935589005427 Transposase domain (DUF772); Region: DUF772; pfam05598 935589005428 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589005429 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 935589005430 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 935589005431 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 935589005432 23S rRNA interface [nucleotide binding]; other site 935589005433 L3 interface [polypeptide binding]; other site 935589005434 Cell division protein ZapA (stimulator of FtsZ polymerization and Z-ring component) [Cell cycle control, cell division, chromosome partitioning]; Region: zapA; COG3027 935589005435 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 935589005436 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 935589005437 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 935589005438 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 935589005439 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 935589005440 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 935589005441 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 935589005442 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 935589005443 ATP binding site [chemical binding]; other site 935589005444 substrate interface [chemical binding]; other site 935589005445 hypothetical protein; Provisional; Region: PRK04325 935589005446 Predicted permease [General function prediction only]; Region: COG2056 935589005447 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 935589005448 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 935589005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 935589005450 S-adenosylmethionine binding site [chemical binding]; other site 935589005451 protease TldD; Provisional; Region: tldD; PRK10735 935589005452 putative hydroxymethylpyrimidine transporter CytX; Region: thia_cytX; TIGR02358 935589005453 Na binding site [ion binding]; other site 935589005454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 935589005455 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 935589005456 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 935589005457 thiamine phosphate binding site [chemical binding]; other site 935589005458 active site 935589005459 pyrophosphate binding site [ion binding]; other site 935589005460 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 935589005461 thiS-thiF/thiG interaction site; other site 935589005462 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 935589005463 ThiS interaction site; other site 935589005464 putative active site [active] 935589005465 tetramer interface [polypeptide binding]; other site 935589005466 Sporulation related domain; Region: SPOR; pfam05036 935589005467 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/pantothenate kinase; Reviewed; Region: PRK13325 935589005468 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 935589005469 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 935589005470 Pantothenate kinase type III (Bvg accessory factor family protein) [Transcription]; Region: COG1521 935589005471 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 935589005472 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 935589005473 active site 935589005474 HIGH motif; other site 935589005475 nucleotide binding site [chemical binding]; other site 935589005476 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 935589005477 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 935589005478 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 935589005479 homodimer interface [polypeptide binding]; other site 935589005480 NADP binding site [chemical binding]; other site 935589005481 substrate binding site [chemical binding]; other site 935589005482 RDD family; Region: RDD; pfam06271 935589005483 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 935589005484 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 935589005485 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 935589005486 putative active site [active] 935589005487 putative catalytic site [active] 935589005488 putative DNA binding site [nucleotide binding]; other site 935589005489 putative phosphate binding site [ion binding]; other site 935589005490 metal binding site A [ion binding]; metal-binding site 935589005491 putative AP binding site [nucleotide binding]; other site 935589005492 putative metal binding site B [ion binding]; other site 935589005493 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 935589005494 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935589005495 active site 935589005496 HIGH motif; other site 935589005497 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 935589005498 KMSKS motif; other site 935589005499 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 935589005500 tRNA binding surface [nucleotide binding]; other site 935589005501 anticodon binding site; other site 935589005502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589005503 AAA domain; Region: AAA_21; pfam13304 935589005504 Walker A/P-loop; other site 935589005505 ATP binding site [chemical binding]; other site 935589005506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 935589005507 ABC transporter signature motif; other site 935589005508 Walker B; other site 935589005509 D-loop; other site 935589005510 H-loop/switch region; other site 935589005511 GTPase CgtA; Reviewed; Region: obgE; PRK12299 935589005512 GTP1/OBG; Region: GTP1_OBG; pfam01018 935589005513 Obg GTPase; Region: Obg; cd01898 935589005514 G1 box; other site 935589005515 GTP/Mg2+ binding site [chemical binding]; other site 935589005516 Switch I region; other site 935589005517 G2 box; other site 935589005518 G3 box; other site 935589005519 Switch II region; other site 935589005520 G4 box; other site 935589005521 G5 box; other site 935589005522 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 935589005523 Predicted methyltransferases [General function prediction only]; Region: COG0313 935589005524 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 935589005525 putative SAM binding site [chemical binding]; other site 935589005526 putative homodimer interface [polypeptide binding]; other site 935589005527 Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792 935589005528 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 935589005529 dimer interface [polypeptide binding]; other site 935589005530 active site 935589005531 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 935589005532 BON domain; Region: BON; pfam04972 935589005533 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 935589005534 active site 935589005535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 935589005536 non-specific DNA binding site [nucleotide binding]; other site 935589005537 salt bridge; other site 935589005538 sequence-specific DNA binding site [nucleotide binding]; other site 935589005539 malate:quinone oxidoreductase; Validated; Region: PRK05257 935589005540 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 935589005541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 935589005542 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 935589005543 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 935589005544 rRNA interaction site [nucleotide binding]; other site 935589005545 S8 interaction site; other site 935589005546 putative laminin-1 binding site; other site 935589005547 elongation factor Ts; Provisional; Region: tsf; PRK09377 935589005548 UBA/TS-N domain; Region: UBA; pfam00627 935589005549 Elongation factor TS; Region: EF_TS; pfam00889 935589005550 Elongation factor TS; Region: EF_TS; pfam00889 935589005551 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 935589005552 putative nucleotide binding site [chemical binding]; other site 935589005553 uridine monophosphate binding site [chemical binding]; other site 935589005554 homohexameric interface [polypeptide binding]; other site 935589005555 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935589005556 Protein of unknown function (DUF1020); Region: DUF1020; pfam06255 935589005557 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 935589005558 Pyocin large subunit [General function prediction only]; Region: COG5529 935589005559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 935589005560 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 935589005561 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 935589005562 tandem repeat interface [polypeptide binding]; other site 935589005563 oligomer interface [polypeptide binding]; other site 935589005564 active site residues [active] 935589005565 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 935589005566 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 935589005567 putative MPT binding site; other site 935589005568 argininosuccinate synthase; Validated; Region: PRK05370 935589005569 argininosuccinate synthase; Provisional; Region: PRK13820 935589005570 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 935589005571 serine/threonine transporter SstT; Provisional; Region: PRK13628 935589005572 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 935589005573 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 935589005574 Surface antigen; Region: Bac_surface_Ag; pfam01103 935589005575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 935589005576 Family of unknown function (DUF490); Region: DUF490; pfam04357 935589005577 Family of unknown function (DUF490); Region: DUF490; pfam04357 935589005578 Family of unknown function (DUF490); Region: DUF490; pfam04357 935589005579 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 935589005580 POT family; Region: PTR2; cl17359 935589005581 peptide chain release factor 2; Validated; Region: prfB; PRK00578 935589005582 This domain is found in peptide chain release factors; Region: PCRF; smart00937 935589005583 RF-1 domain; Region: RF-1; pfam00472 935589005584 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 935589005585 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 935589005586 active site 935589005587 nucleophile elbow; other site 935589005588 Predicted membrane protein [Function unknown]; Region: COG2259 935589005589 Protein of unknown function (DUF692); Region: DUF692; pfam05114 935589005590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3219 935589005591 RNA polymerase sigma factor; Provisional; Region: PRK12532 935589005592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 935589005593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 935589005594 DNA binding residues [nucleotide binding] 935589005595 Transposase domain (DUF772); Region: DUF772; pfam05598 935589005596 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 935589005597 DDE superfamily endonuclease; Region: DDE_4; cl17710 935589005598 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 935589005599 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 935589005600 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 935589005601 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 935589005602 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 935589005603 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 935589005604 Uncharacterized conserved protein [Function unknown]; Region: COG1739 935589005605 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 935589005606 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 935589005607 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 935589005608 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 935589005609 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 935589005610 Ligand binding site [chemical binding]; other site 935589005611 Electron transfer flavoprotein domain; Region: ETF; pfam01012 935589005612 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 935589005613 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 935589005614 putative active site [active] 935589005615 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 935589005616 Isochorismatase family; Region: Isochorismatase; pfam00857 935589005617 catalytic triad [active] 935589005618 metal binding site [ion binding]; metal-binding site 935589005619 conserved cis-peptide bond; other site 935589005620 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 935589005621 homodimer interaction site [polypeptide binding]; other site 935589005622 cofactor binding site; other site 935589005623 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 935589005624 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 935589005625 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 935589005626 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 935589005627 MutS domain I; Region: MutS_I; pfam01624 935589005628 MutS domain II; Region: MutS_II; pfam05188 935589005629 MutS domain III; Region: MutS_III; pfam05192 935589005630 MutS domain V; Region: MutS_V; pfam00488 935589005631 Walker A/P-loop; other site 935589005632 ATP binding site [chemical binding]; other site 935589005633 Q-loop/lid; other site 935589005634 ABC transporter signature motif; other site 935589005635 Walker B; other site 935589005636 D-loop; other site 935589005637 H-loop/switch region; other site